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Nature Reviews Molecular Cell Biology
Journal Prestige (SJR): 32.714
Citation Impact (citeScore): 21
Number of Followers: 389  
 
  Full-text available via subscription Subscription journal
ISSN (Print) 1471-0072 - ISSN (Online) 1471-0080
Published by NPG Homepage  [144 journals]
  • Regulation of chromatin and gene expression by metabolic enzymes and
           metabolites
    • Regulation of chromatin and gene expression by metabolic enzymes and metabolites

      Regulation of chromatin and gene expression by metabolic enzymes and metabolites, Published online: 21 June 2018; doi:10.1038/s41580-018-0029-7

      Metabolism feeds into gene regulation, allowing adaptation of gene expression to satisfy cellular needs, including in pathological scenarios such as cancer. Metabolism modulates gene expression through metabolites, which serve as cofactors for DNA and histone modifiers, and through metabolic enzymes, which locally regulate chromatin and transcription in the nucleus.Regulation of chromatin and gene expression by metabolic enzymes and metabolites, Published online: 2018-06-21; doi:10.1038/s41580-018-0029-72018-06-21
      DOI: 10.1038/s41580-018-0029-7
       
  • Falling short to compete
    • Falling short to compete

      Falling short to compete, Published online: 08 June 2018; doi:10.1038/s41580-018-0032-z

      Increased shortening of RNA 3′ untranslated regions associated with tumorigenic transformation interferes with competing endogenous RNA (ceRNA) networks, which results in trans-repression of tumour suppressors through microRNA-mediated silencing.Falling short to compete, Published online: 2018-06-08; doi:10.1038/s41580-018-0032-z2018-06-08
      DOI: 10.1038/s41580-018-0032-z
       
  • A self-made quiescent niche
    • A self-made quiescent niche

      A self-made quiescent niche, Published online: 06 June 2018; doi:10.1038/s41580-018-0031-0

      Muscle stem cells produce collagen V, which becomes a component of the niche that promotes their quiescence.A self-made quiescent niche, Published online: 2018-06-06; doi:10.1038/s41580-018-0031-02018-06-06
      DOI: 10.1038/s41580-018-0031-0
       
  • Cellular and epigenetic drivers of stem cell ageing
    • Cellular and epigenetic drivers of stem cell ageing

      Cellular and epigenetic drivers of stem cell ageing, Published online: 01 June 2018; doi:10.1038/s41580-018-0020-3

      The δ-cells of the pancreatic islets secrete somatostatin, which inhibits insulin and glucagon secretion. In this Review, the authors summarize the cellular physiology of somatostatin secretion, how this might go wrong in diabetes mellitus and potential therapeutic targets.Cellular and epigenetic drivers of stem cell ageing, Published online: 2018-06-01; doi:10.1038/s41580-018-0020-32018-06-01
      DOI: 10.1038/s41580-018-0020-3
       
  • Designing cell function: assembly of synthetic gene circuits for cell
           biology applications
    • Designing cell function: assembly of synthetic gene circuits for cell biology applications

      Designing cell function: assembly of synthetic gene circuits for cell biology applications, Published online: 01 June 2018; doi:10.1038/s41580-018-0024-z

      Taking advantage of genetic engineering, synthetic biology allows control and design of new cell functions. Recent advances in the development of genetic tools and the assembly of progressively more sophisticated gene circuits have made ‘designer cells’ a reality, with applications ranging from industry and biotechnology to medicine.Designing cell function: assembly of synthetic gene circuits for cell biology applications, Published online: 2018-06-01; doi:10.1038/s41580-018-0024-z2018-06-01
      DOI: 10.1038/s41580-018-0024-z
       
  • The functions and regulation of the PTEN tumour suppressor: new modes and
           prospects
    • The functions and regulation of the PTEN tumour suppressor: new modes and prospects

      The functions and regulation of the PTEN tumour suppressor: new modes and prospects, Published online: 01 June 2018; doi:10.1038/s41580-018-0015-0

      The tumour suppressor PTEN regulates various cellular processes, including maintenance of genomic stability, cell survival, migration, proliferation and metabolism. Recent studies into the regulation of PTEN levels and activity provide new insights into its anti-oncogenic functions and offer novel opportunities for cancer treatment.The functions and regulation of the PTEN tumour suppressor: new modes and prospects, Published online: 2018-06-01; doi:10.1038/s41580-018-0015-02018-06-01
      DOI: 10.1038/s41580-018-0015-0
       
  • Dynamics and function of DNA methylation in plants
    • Dynamics and function of DNA methylation in plants

      Dynamics and function of DNA methylation in plants, Published online: 21 May 2018; doi:10.1038/s41580-018-0016-z

      DNA methylation in plants mediates gene expression, transposon silencing, chromosome interactions and genome stability. It is therefore not surprising that the regulation of DNA methylation is important for plant development and for plant responses to biotic and abiotic stresses.Dynamics and function of DNA methylation in plants, Published online: 2018-05-21; doi:10.1038/s41580-018-0016-z2018-05-21
      DOI: 10.1038/s41580-018-0016-z
       
  • Why does biopolymer condensation matter'
    • Why does biopolymer condensation matter?

      Why does biopolymer condensation matter?, Published online: 16 May 2018; doi:10.1038/s41580-018-0023-0

      Biomolecules can phase separate and form condensates that have roles in diverse cellular processes and contexts. Michnick and Bergeron-Sandoval comment on this rapidly progressing field and envisage that the study of biological phase separation will bring new understanding of cell and developmental biology.Why does biopolymer condensation matter?, Published online: 2018-05-16; doi:10.1038/s41580-018-0023-02018-05-16
      DOI: 10.1038/s41580-018-0023-0
       
 
 
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