Journal Cover
Nature Reviews Molecular Cell Biology
Journal Prestige (SJR): 32.714
Citation Impact (citeScore): 21
Number of Followers: 477  
 
  Full-text available via subscription Subscription journal
ISSN (Print) 1471-0072 - ISSN (Online) 1471-0080
Published by NPG Homepage  [137 journals]
  • Human cohesin extrudes interphase DNA to make loops
    • Nature Reviews Molecular Cell Biology, Published online: 29 November 2019; doi:10.1038/s41580-019-0198-z

      Cohesin is reported to form DNA loops in interphase chromatin by a mechanism of DNA loop extrusion.Nature Reviews Molecular Cell Biology, Published online: 2019-11-29; doi:10.1038/s41580-019-0198-z2019-11-29
      DOI: 10.1038/s41580-019-0198-z
       
  • Molecular mechanisms and physiological importance of circadian rhythms
    • Nature Reviews Molecular Cell Biology, Published online: 25 November 2019; doi:10.1038/s41580-019-0179-2

      Animal circadian rhythms are controlled by central and peripheral molecular clocks, whose components generate oscillations in their own abundance and activity. Insights into how these clocks time the function of organs and tissues is increasing our understanding of animal physiology.Nature Reviews Molecular Cell Biology, Published online: 2019-11-25; doi:10.1038/s41580-019-0179-22019-11-25
      DOI: 10.1038/s41580-019-0179-2
       
  • Integrator of stress cues
    • Nature Reviews Molecular Cell Biology, Published online: 25 November 2019; doi:10.1038/s41580-019-0197-0

      The Integrator complex fine-tunes mRNA levels in response to stress by attenuating productive transcription elongationNature Reviews Molecular Cell Biology, Published online: 2019-11-25; doi:10.1038/s41580-019-0197-02019-11-25
      DOI: 10.1038/s41580-019-0197-0
       
  • Lysosomes as dynamic regulators of cell and organismal homeostasis
    • Nature Reviews Molecular Cell Biology, Published online: 25 November 2019; doi:10.1038/s41580-019-0185-4

      Lysosomes are mainly associated with cellular waste disposal. But it has recently been discovered that by integrating various environmental cues, they have a broader role as regulatory hubs for cellular and organismal homeostasis. The modulation of lysosome function could thus be a promising therapeutic strategy for the treatment of cancer as well as metabolic and neurodegenerative disorders.Nature Reviews Molecular Cell Biology, Published online: 2019-11-25; doi:10.1038/s41580-019-0185-42019-11-25
      DOI: 10.1038/s41580-019-0185-4
       
  • Mitosis flips the switch on autophagy control
    • Nature Reviews Molecular Cell Biology, Published online: 22 November 2019; doi:10.1038/s41580-019-0196-1

      Nutrient status is uncoupled from the control of autophagy during mitosis through a switch from mTORC1- to CDK1-mediated inhibition of autophagy regulators.Nature Reviews Molecular Cell Biology, Published online: 2019-11-22; doi:10.1038/s41580-019-0196-12019-11-22
      DOI: 10.1038/s41580-019-0196-1
       
  • The molecular principles governing the activity and functional diversity
           of AAA+ proteins
    • Nature Reviews Molecular Cell Biology, Published online: 21 November 2019; doi:10.1038/s41580-019-0183-6

      AAA+ proteins are macromolecular machines that remodel a vast array of cellular substrates, including protein aggregates, macromolecular complexes and polymers. Recent advances in cryo-electron microscopy have enabled visualization of them while in action, leading to a better understanding of the mechanisms of engagement and processing of their diverse substrates.Nature Reviews Molecular Cell Biology, Published online: 2019-11-21; doi:10.1038/s41580-019-0183-62019-11-21
      DOI: 10.1038/s41580-019-0183-6
       
  • Iron expulsion by exosomes drives ferroptosis resistance
    • Nature Reviews Molecular Cell Biology, Published online: 20 November 2019; doi:10.1038/s41580-019-0195-2

      Exosomes are a route for expelling iron out of cells exposed to ferroptotic stimuli, thereby protecting them from ferroptotic cell death.Nature Reviews Molecular Cell Biology, Published online: 2019-11-20; doi:10.1038/s41580-019-0195-22019-11-20
      DOI: 10.1038/s41580-019-0195-2
       
  • The functional universe of membrane contact sites
    • Nature Reviews Molecular Cell Biology, Published online: 15 November 2019; doi:10.1038/s41580-019-0180-9

      Although organelles compartmentalize eukaryotic cells, they can communicate and integrate their activities by connecting at membrane contact sites (MCSs). The roles of MCSs in biology are becoming increasingly clear, with MCSs now known to function in intracellular signalling, lipid metabolism, membrane dynamics, organelle biogenesis and the cellular stress response.Nature Reviews Molecular Cell Biology, Published online: 2019-11-15; doi:10.1038/s41580-019-0180-92019-11-15
      DOI: 10.1038/s41580-019-0180-9
       
 
 
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