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Nature Reviews Molecular Cell Biology
Journal Prestige (SJR): 32.714
Citation Impact (citeScore): 21
Number of Followers: 499  
 
  Full-text available via subscription Subscription journal
ISSN (Print) 1471-0072 - ISSN (Online) 1471-0080
Published by NPG Homepage  [138 journals]
  • Human organoids: model systems for human biology and medicine
    • Nature Reviews Molecular Cell Biology, Published online: 07 July 2020; doi:10.1038/s41580-020-0259-3

      Human organoids are valuable models for the study of development and disease and for drug discovery, thus complementing traditional animal models. The generation of organoids from patient biopsy samples has enabled researchers to study, for example, infectious diseases, genetic disorders and cancers. This Review discusses the advantages, disadvantages and future challenges of the use of organoids as models for human biology.Nature Reviews Molecular Cell Biology, Published online: 2020-07-07; doi:10.1038/s41580-020-0259-32020-07-07
      DOI: 10.1038/s41580-020-0259-3
       
  • RNA contributions to the form and function of biomolecular condensates
    • Nature Reviews Molecular Cell Biology, Published online: 06 July 2020; doi:10.1038/s41580-020-0264-6

      Recent studies have highlighted the contribution of RNA to cellular liquid–liquid phase separation and condensate formation. RNA features modulate the composition and biophysical properties of RNA–protein condensates, which have various cellular functions, including RNA transport and localization, supporting catalytic processes and responding to stress.Nature Reviews Molecular Cell Biology, Published online: 2020-07-06; doi:10.1038/s41580-020-0264-62020-07-06
      DOI: 10.1038/s41580-020-0264-6
       
  • CircRNAs in lifespan
    • Nature Reviews Molecular Cell Biology, Published online: 02 July 2020; doi:10.1038/s41580-020-0269-1

      Increased expression of the circular RNA generated by the sulfateless gene (circSfl), and of the protein it encodes, can extend the lifespan of flies.Nature Reviews Molecular Cell Biology, Published online: 2020-07-02; doi:10.1038/s41580-020-0269-12020-07-02
      DOI: 10.1038/s41580-020-0269-1
       
  • The plasticity of DNA replication forks in response to clinically relevant
           genotoxic stress
    • Nature Reviews Molecular Cell Biology, Published online: 01 July 2020; doi:10.1038/s41580-020-0257-5

      Different obstacles can stall the progression of replication forks. Recent studies have revealed that stalled forks are remarkably diverse in their composition and architecture. This plasticity enables fork remodelling, processing and restart in response to specific types of replication stress, thereby influencing tumorigenesis and innate immunity.Nature Reviews Molecular Cell Biology, Published online: 2020-07-01; doi:10.1038/s41580-020-0257-52020-07-01
      DOI: 10.1038/s41580-020-0257-5
       
  • The network effect: studying COVID-19 pathology with the Human Cell Atlas
    • Nature Reviews Molecular Cell Biology, Published online: 30 June 2020; doi:10.1038/s41580-020-0267-3

      The Human Cell Atlas consortium in collaborative work on COVID-19Nature Reviews Molecular Cell Biology, Published online: 2020-06-30; doi:10.1038/s41580-020-0267-32020-06-30
      DOI: 10.1038/s41580-020-0267-3
       
  • Drugs enter a liquid phase
    • Nature Reviews Molecular Cell Biology, Published online: 29 June 2020; doi:10.1038/s41580-020-0268-2

      Young and colleagues show that anti-cancer compounds can undergo partitioning into biomolecular condensates, affecting their activity.Nature Reviews Molecular Cell Biology, Published online: 2020-06-29; doi:10.1038/s41580-020-0268-22020-06-29
      DOI: 10.1038/s41580-020-0268-2
       
  • ERK signalling: a master regulator of cell behaviour, life and fate
    • Nature Reviews Molecular Cell Biology, Published online: 23 June 2020; doi:10.1038/s41580-020-0255-7

      Extracellular signal-regulated kinase 1 (ERK1) and ERK2 relay cell growth and mitogenic signals to multiple substrates, and thus control essential physiological processes. This Review discusses the regulation of ERKs, and their control of cell proliferation, cell survival, cell growth, cell metabolism, cell migration and cell differentiation.Nature Reviews Molecular Cell Biology, Published online: 2020-06-23; doi:10.1038/s41580-020-0255-72020-06-23
      DOI: 10.1038/s41580-020-0255-7
       
  • Old and new models for the study of human ageing
    • Nature Reviews Molecular Cell Biology, Published online: 22 June 2020; doi:10.1038/s41580-020-0266-4

      Anne Brunet discusses the different model organisms that are used for the study of ageing mechanisms and their advantages and disadvantages.Nature Reviews Molecular Cell Biology, Published online: 2020-06-22; doi:10.1038/s41580-020-0266-42020-06-22
      DOI: 10.1038/s41580-020-0266-4
       
 
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