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Journal Cover Nature Reviews Molecular Cell Biology
  [SJR: 32.928]   [H-I: 324]   [382 followers]  Follow
    
   Full-text available via subscription Subscription journal
   ISSN (Print) 1471-0072 - ISSN (Online) 1471-0080
   Published by NPG Homepage  [135 journals]
  • Stem cells: A balancing act of lipids
    • Stem cells: A balancing act of lipids

      Stem cells: A balancing act of lipids, Published online: 07 February 2018; doi:10.1038/nrm.2018.10

      Perturbation of phospholipid composition in intestinal stem cells (ISCs) results in increased cholesterol biosynthesis; excess cholesterol is a driver of ISC hyperproliferation, and consequently of intestinal hypertrophy and cancer.Stem cells: A balancing act of lipids, Published online: 2018-02-07; doi:10.1038/nrm.2018.102018-02-07
      DOI: 10.1038/nrm.2018.10
       
  • RNA metabolism: Interfering with interferon by RNA editing
    • RNA metabolism: Interfering with interferon by RNA editing

      RNA metabolism: Interfering with interferon by RNA editing, Published online: 07 February 2018; doi:10.1038/nrm.2018.12

      By editing of endogenous mRNAs, the RNA editing enzyme ADAR1 prevents interferon-induced translation shutdown and cell death, and virus-independent interferon induction in neuronal cells.RNA metabolism: Interfering with interferon by RNA editing, Published online: 2018-02-07; doi:10.1038/nrm.2018.122018-02-07
      DOI: 10.1038/nrm.2018.12
       
  • Ubiquitin chains as second messengers
    • Ubiquitin chains as second messengers

      Ubiquitin chains as second messengers, Published online: 07 February 2018; doi:10.1038/nrm.2018.9

      Philip Cohen highlights how two studies from the laboratory of Zhijian Chen, pubished in 2000 and 2001, started a new era in the study of signal transduction pathways and the roles of ubiquitin chains.Ubiquitin chains as second messengers, Published online: 2018-02-07; doi:10.1038/nrm.2018.92018-02-07
      DOI: 10.1038/nrm.2018.9
       
  • Mechanisms of clathrin-mediated endocytosis
    • Mechanisms of clathrin-mediated endocytosis

      Mechanisms of clathrin-mediated endocytosis, Published online: 07 February 2018; doi:10.1038/nrm.2017.132

      Clathrin-mediated endocytosis is the main mechanism for internalization of cell-surface molecules and surface-bound cargoes. Although the machineries that drive the formation of endocytic vesicle are intricate, an understanding of endocytosis is being unravelled at the molecular level.Mechanisms of clathrin-mediated endocytosis, Published online: 2018-02-07; doi:10.1038/nrm.2017.1322018-02-07
      DOI: 10.1038/nrm.2017.132
       
  • Understanding the diversity of membrane lipid composition
    • Understanding the diversity of membrane lipid composition

      Understanding the diversity of membrane lipid composition, Published online: 07 February 2018; doi:10.1038/nrm.2017.138

      Membrane lipids exhibit a remarkable diversity — they vary in structure and chemical properties, and their distribution between different membranes and their subcompartments is highly heterogeneous. Recent progress in studies of membrane lipids has broadened our understanding of how this diversity affects membrane properties and membrane-associated processes.Understanding the diversity of membrane lipid composition, Published online: 2018-02-07; doi:10.1038/nrm.2017.1382018-02-07
      DOI: 10.1038/nrm.2017.138
       
  • The future of CRISPR technologies in agriculture
    • The future of CRISPR technologies in agriculture

      The future of CRISPR technologies in agriculture, Published online: 31 January 2018; doi:10.1038/nrm.2018.2

      Caixia Gao outlines the technical, regulatory and public opinion hurdles for the future use of CRISPR technologies in plant breeding.The future of CRISPR technologies in agriculture, Published online: 2018-01-31; doi:10.1038/nrm.2018.22018-01-31
      DOI: 10.1038/nrm.2018.2
       
  • Mechanisms of disease: Consequences of mitoribosome overload
    • Mechanisms of disease: Consequences of mitoribosome overload

      Mechanisms of disease: Consequences of mitoribosome overload, Published online: 31 January 2018; doi:10.1038/nrm.2018.8

      The exonuclease EXD2 prevents the overload of the mitochondrial 28S ribosome subunit with mitochondrial mRNAs, and is important for development and lifespan regulationMechanisms of disease: Consequences of mitoribosome overload, Published online: 2018-01-31; doi:10.1038/nrm.2018.82018-01-31
      DOI: 10.1038/nrm.2018.8
       
  • Once and only once: mechanisms of centriole duplication and their
           deregulation in disease
    • Once and only once: mechanisms of centriole duplication and their deregulation in disease

      Once and only once: mechanisms of centriole duplication and their deregulation in disease, Published online: 24 January 2018; doi:10.1038/nrm.2017.127

      Most eukaryotic cells contain a single centrosome with a pair of centrioles, which duplicate before mitosis. Defects in duplication lead to aberrant numbers of centrioles and centrosomes. Recent insights into mechanisms of centriole biogenesis and centriole number control are helping us to better understand the links between aberrant centrosome number and human disease.Once and only once: mechanisms of centriole duplication and their deregulation in disease, Published online: 2018-01-24; doi:10.1038/nrm.2017.1272018-01-24
      DOI: 10.1038/nrm.2017.127
       
 
 
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