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Nature Reviews Molecular Cell Biology
Journal Prestige (SJR): 32.714
Citation Impact (citeScore): 21
Number of Followers: 461  
 
  Full-text available via subscription Subscription journal
ISSN (Print) 1471-0072 - ISSN (Online) 1471-0080
Published by NPG Homepage  [138 journals]
  • Advances in protein structure prediction and design
    • Nature Reviews Molecular Cell Biology, Published online: 15 August 2019; doi:10.1038/s41580-019-0163-x

      Predicting how proteins fold enables inferring their function. Conversely, rational protein design allows for engineering novel protein functionalities. Recent improvements in computational algorithms and technological advances have dramatically increased the accuracy and speed of protein structure modelling, providing novel opportunities for controlling protein function, with potential applications in biomedicine, industry and research.Nature Reviews Molecular Cell Biology, Published online: 2019-08-15; doi:10.1038/s41580-019-0163-x2019-08-15
      DOI: 10.1038/s41580-019-0163-x
       
  • The diverse roles of DNA methylation in mammalian development and disease
    • Nature Reviews Molecular Cell Biology, Published online: 09 August 2019; doi:10.1038/s41580-019-0159-6

      DNA methylation is essential for mammalian embryogenesis owing to its repression of transposons and genes, but it is also associated with gene activation. The recent use of sensitive technologies has revealed that DNA methylation dynamics vary considerably between embryonic, germline and somatic cell development, with implications for genetic diseases and cancer.Nature Reviews Molecular Cell Biology, Published online: 2019-08-09; doi:10.1038/s41580-019-0159-62019-08-09
      DOI: 10.1038/s41580-019-0159-6
       
  • m5C mRNAs on the move
    • Nature Reviews Molecular Cell Biology, Published online: 05 August 2019; doi:10.1038/s41580-019-0167-6

      Cytosine methylation (m5C) in mRNAs is important for their transport to distant tissues in plants.Nature Reviews Molecular Cell Biology, Published online: 2019-08-05; doi:10.1038/s41580-019-0167-62019-08-05
      DOI: 10.1038/s41580-019-0167-6
       
  • Author Correction: The regulation, functions and clinical relevance of
           arginine methylation
    • Nature Reviews Molecular Cell Biology, Published online: 02 August 2019; doi:10.1038/s41580-019-0166-7

      Author Correction: The regulation, functions and clinical relevance of arginine methylationNature Reviews Molecular Cell Biology, Published online: 2019-08-02; doi:10.1038/s41580-019-0166-72019-08-02
      DOI: 10.1038/s41580-019-0166-7
       
  • Emil Heitz, a true epigenetics pioneer
    • Nature Reviews Molecular Cell Biology, Published online: 01 August 2019; doi:10.1038/s41580-019-0161-z

      Emil Heitz was a pioneer of epigenetics at a time when the nature of the heredity material was still unclear.Nature Reviews Molecular Cell Biology, Published online: 2019-08-01; doi:10.1038/s41580-019-0161-z2019-08-01
      DOI: 10.1038/s41580-019-0161-z
       
  • Insights into the kinetics of microRNA biogenesis and turnover
    • Nature Reviews Molecular Cell Biology, Published online: 31 July 2019; doi:10.1038/s41580-019-0164-9

      Restricted Argonaute expression supports selective interaction with microRNAs, which is essential for microRNA stability.Nature Reviews Molecular Cell Biology, Published online: 2019-07-31; doi:10.1038/s41580-019-0164-92019-07-31
      DOI: 10.1038/s41580-019-0164-9
       
  • Parkin and AMPK team up against necroptosis
    • Nature Reviews Molecular Cell Biology, Published online: 31 July 2019; doi:10.1038/s41580-019-0165-8

      Ubiquitin ligase parkin — a key mediator of mitophagy — is induced in necroptotic conditions through the activity of AMP-activated protein kinase (AMPK) to restrain necroptosis and limit associated pathologies.Nature Reviews Molecular Cell Biology, Published online: 2019-07-31; doi:10.1038/s41580-019-0165-82019-07-31
      DOI: 10.1038/s41580-019-0165-8
       
  • The regulation, functions and clinical relevance of arginine methylation
    • Nature Reviews Molecular Cell Biology, Published online: 26 July 2019; doi:10.1038/s41580-019-0155-x

      The methylation of arginine residues regulates gene expression, DNA repair, growth factor signalling and liquid–liquid phase separation. Targeting this modification can thus be therapeutically relevant and inhibitors of arginine methylation are being tested in clinical trials, especially for neurodegenerative diseases and cancer.Nature Reviews Molecular Cell Biology, Published online: 2019-07-26; doi:10.1038/s41580-019-0155-x2019-07-26
      DOI: 10.1038/s41580-019-0155-x
       
 
 
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