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Journal Cover Nature Reviews Molecular Cell Biology
  [SJR: 32.928]   [H-I: 324]   [388 followers]  Follow
    
   Full-text available via subscription Subscription journal
   ISSN (Print) 1471-0072 - ISSN (Online) 1471-0080
   Published by NPG Homepage  [134 journals]
  • The functions and unique features of long intergenic non-coding RNA
    • The functions and unique features of long intergenic non-coding RNA

      The functions and unique features of long intergenic non-coding RNA, Published online: 15 November 2017; doi:10.1038/nrm.2017.104

      NatureArticleSnippet(type=short-summary, markup=

      Long intergenic non-coding RNAs (lincRNAs) do not overlap protein-coding genes, although some lincRNA genes have minimal coding potential and can include small open reading frames that encode functional peptides. lincRNA functions include RNA stabilization and transcription regulation and the remodelling of chromatin and genome architecture. Recent insights suggest that lincRNAs broadly serve to fine-tune the expression of neighbouring genes with remarkable tissue specificity.

      , isJats=true)The functions and unique features of long intergenic non-coding RNA, Published online: 2017-11-15; doi:10.1038/nrm.2017.1042017-11-15
      DOI: 10.1038/nrm.2017.104
       
  • Mechanical forces direct stem cell behaviour in development and
           regeneration
    • Mechanical forces direct stem cell behaviour in development and regeneration

      Mechanical forces direct stem cell behaviour in development and regeneration, Published online: 08 November 2017; doi:10.1038/nrm.2017.108

      NatureArticleSnippet(type=short-summary, markup=

      Physical cues regulate stem cell fate and function during embryonic development and in adult tissues. The biophysical and biochemical properties of the stem cell microenvironment can be precisely manipulated using synthetic niches, which provide key insights into how mechanical stimuli regulate stem cell function and can be used to maintain and guide stem cells for regenerative therapies.

      , isJats=true)Mechanical forces direct stem cell behaviour in development and regeneration, Published online: 2017-11-08; doi:10.1038/nrm.2017.1082017-11-08
      DOI: 10.1038/nrm.2017.108
       
  • Mechanobiology of collective cell behaviours
    • Mechanobiology of collective cell behaviours

      Mechanobiology of collective cell behaviours, Published online: 08 November 2017; doi:10.1038/nrm.2017.98

      NatureArticleSnippet(type=short-summary, markup=

      Coordinated movements of cell collectives are important for morphogenesis, tissue regeneration and cancer cell dissemination. Recent studies, mainly using novel in vitro approaches, have provided new insights into the mechanisms governing this multicellular coordination, highlighting the key role of the mechanosensitivity of adherens junctions and mechanical cell–cell coupling in collective cell behaviours.

      , isJats=true)Mechanobiology of collective cell behaviours, Published online: 2017-11-08; doi:10.1038/nrm.2017.982017-11-08
      DOI: 10.1038/nrm.2017.98
       
  • Publisher correction: The essential kinase ATR: ensuring faithful
           duplication of a challenging genome.
    • Publisher correction: The essential kinase ATR: ensuring faithful duplication of a challenging genome.

      Publisher correction: The essential kinase ATR: ensuring faithful duplication of a challenging genome., Published online: 08 November 2017; doi:10.1038/nrm.2017.116

      Publisher correction: The essential kinase ATR: ensuring faithful duplication of a challenging genome., Published online: 2017-11-08; doi:10.1038/nrm.2017.1162017-11-08
      DOI: 10.1038/nrm.2017.116
       
  • Translation: Immature ribosomes under surveillance
    • Translation: Immature ribosomes under surveillance

      Translation: Immature ribosomes under surveillance, Published online: 08 November 2017; doi:10.1038/nrm.2017.117

      NatureArticleSnippet(type=short-summary, markup=

      Ribosome subunits that fail to properly mature enter translation, cause translational stress and become targets of translation surveillance pathways.

      , isJats=true)Translation: Immature ribosomes under surveillance, Published online: 2017-11-08; doi:10.1038/nrm.2017.1172017-11-08
      DOI: 10.1038/nrm.2017.117
       
  • Forces as regulators of cell adhesions
    • Forces as regulators of cell adhesions

      Forces as regulators of cell adhesions, Published online: 02 November 2017; doi:10.1038/nrm.2017.112

      NatureArticleSnippet(type=short-summary, markup=

      Christopher Chen highlights the early studies of mechanoregulation of cell–matrix adhesions that established mechanobiology as a cross-discplinary research field

      , isJats=true)Forces as regulators of cell adhesions, Published online: 2017-11-02; doi:10.1038/nrm.2017.1122017-11-02
      DOI: 10.1038/nrm.2017.112
       
  • Mechanotransduction: Enforcing protein import
    • Mechanotransduction: Enforcing protein import

      Mechanotransduction: Enforcing protein import, Published online: 02 November 2017; doi:10.1038/nrm.2017.114

      NatureArticleSnippet(type=short-summary, markup=

      Applying force to the nucleus reduces the diffusion barrier at nuclear pores and promotes nuclear import of certain proteins, including the transcription regulator YAP, depending on their molecular properties.

      , isJats=true)Mechanotransduction: Enforcing protein import, Published online: 2017-11-02; doi:10.1038/nrm.2017.1142017-11-02
      DOI: 10.1038/nrm.2017.114
       
  • Mechanobiology by the numbers: a close relationship between biology and
           physics
    • Mechanobiology by the numbers: a close relationship between biology and physics

      Mechanobiology by the numbers: a close relationship between biology and physics, Published online: 02 November 2017; doi:10.1038/nrm.2017.109

      NatureArticleSnippet(type=short-summary, markup=

      Studies of mechanobiology lie at the interface of various scientific disciplines from biology to physics. Ulrich Schwarz discusses the importance of technological advances, quantification and modelling for the progress in understanding the role of forces in biology.

      , isJats=true)Mechanobiology by the numbers: a close relationship between biology and physics, Published online: 2017-11-02; doi:10.1038/nrm.2017.1092017-11-02
      DOI: 10.1038/nrm.2017.109
       
 
 
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