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Nature Reviews Molecular Cell Biology
Journal Prestige (SJR): 32.714
Citation Impact (citeScore): 21
Number of Followers: 463  
 
  Full-text available via subscription Subscription journal
ISSN (Print) 1471-0072 - ISSN (Online) 1471-0080
Published by NPG Homepage  [138 journals]
  • Mitochondria as multifaceted regulators of cell death
    • Nature Reviews Molecular Cell Biology, Published online: 21 October 2019; doi:10.1038/s41580-019-0173-8

      Mitochondria are key executioners of apoptosis. However, it has recently become clear that beyond driving apoptosis, mitochondria also contribute to pro-inflammatory signalling and other types of regulated cell death. These functions are relevant to disease and could be targeted in the treatment of, for example, degenerative disorders, infection and cancer.Nature Reviews Molecular Cell Biology, Published online: 2019-10-21; doi:10.1038/s41580-019-0173-82019-10-21
      DOI: 10.1038/s41580-019-0173-8
       
  • mtDNA robs nuclear dNTPs
    • Nature Reviews Molecular Cell Biology, Published online: 07 October 2019; doi:10.1038/s41580-019-0182-7

      Mitochondrial DNA damage causes ageing by having a negative effect on nuclear DNA replication and genome integrity.Nature Reviews Molecular Cell Biology, Published online: 2019-10-07; doi:10.1038/s41580-019-0182-72019-10-07
      DOI: 10.1038/s41580-019-0182-7
       
  • Mechanisms of 3D cell migration
    • Nature Reviews Molecular Cell Biology, Published online: 03 October 2019; doi:10.1038/s41580-019-0172-9

      When cells migrate through complex 3D environments, as are most tissues, they encounter several challenges, including the need to adapt to changing biomechanical properties of the surroundings, squeezing through narrow passages and coordinating motion with other cells. A better understanding of 3D cell migration mechanisms provides key insights into development, tissue regeneration, immune responses and cancer cell dissemination.Nature Reviews Molecular Cell Biology, Published online: 2019-10-03; doi:10.1038/s41580-019-0172-92019-10-03
      DOI: 10.1038/s41580-019-0172-9
       
  • G-tracts give PRC2 the boot
    • Nature Reviews Molecular Cell Biology, Published online: 02 October 2019; doi:10.1038/s41580-019-0184-5

      G-quadruplex-containing RNA binds PRC2, removes it from chromatin and activates gene expression.Nature Reviews Molecular Cell Biology, Published online: 2019-10-02; doi:10.1038/s41580-019-0184-52019-10-02
      DOI: 10.1038/s41580-019-0184-5
       
  • RNA granules take a ride on lysosomes
    • Nature Reviews Molecular Cell Biology, Published online: 30 September 2019; doi:10.1038/s41580-019-0181-8

      Efficient mRNA trafficking is supported by tethering of RNA granules to motile lysosomes through ANXA11.Nature Reviews Molecular Cell Biology, Published online: 2019-09-30; doi:10.1038/s41580-019-0181-82019-09-30
      DOI: 10.1038/s41580-019-0181-8
       
  • The DNA damage response to transcription stress
    • Nature Reviews Molecular Cell Biology, Published online: 26 September 2019; doi:10.1038/s41580-019-0169-4

      Transcription-blocking DNA lesions (TBLs) cause transcription stress and are repaired by transcription-coupled nucleotide excision repair (TC-NER). TBL detection by the stalling of RNA polymerase II is highly efficient but may interfere with repair, and overall with transcription and replication. Consequently, TC-NER deregulation causes hereditary disorders with complex genotype–phenotype correlations.Nature Reviews Molecular Cell Biology, Published online: 2019-09-26; doi:10.1038/s41580-019-0169-42019-09-26
      DOI: 10.1038/s41580-019-0169-4
       
  • Setting the standards for machine learning in biology
    • Nature Reviews Molecular Cell Biology, Published online: 23 September 2019; doi:10.1038/s41580-019-0176-5

      David Jones discusses problems associated with the application of machine learning to biology and advocates for improving publishing standards in this area through a more thorough reporting on the design of the computational experiments.Nature Reviews Molecular Cell Biology, Published online: 2019-09-23; doi:10.1038/s41580-019-0176-52019-09-23
      DOI: 10.1038/s41580-019-0176-5
       
  • Intron definition, exon definition and back-splicing revisited
    • Nature Reviews Molecular Cell Biology, Published online: 23 September 2019; doi:10.1038/s41580-019-0178-3

      The same spliceosome complexes can define both introns and exons; exon definition can cause back-splicing across long exons.Nature Reviews Molecular Cell Biology, Published online: 2019-09-23; doi:10.1038/s41580-019-0178-32019-09-23
      DOI: 10.1038/s41580-019-0178-3
       
 
 
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