Journal Cover
Nature Reviews Immunology
Journal Prestige (SJR): 28.786
Citation Impact (citeScore): 17
Number of Followers: 284  
  Full-text available via subscription Subscription journal
ISSN (Print) 1474-1733 - ISSN (Online) 1474-1741
Published by NPG Homepage  [138 journals]
  • Novel vaccine technologies for the 21st century
    • Nature Reviews Immunology, Published online: 11 November 2019; doi:10.1038/s41577-019-0243-3

      New approaches to vaccine development have generated exciting results over the past 18 months. Focusing on respiratory syncytial virus infection, influenza and tuberculosis, Fauci and Mascola discuss the impact of structure-based vaccine design, gene-based vaccine platforms and advances in adjuvant development.Nature Reviews Immunology, Published online: 2019-11-11; doi:10.1038/s41577-019-0243-32019-11-11
      DOI: 10.1038/s41577-019-0243-3
  • Viral villain turns hero in skin cancer
    • Nature Reviews Immunology, Published online: 08 November 2019; doi:10.1038/s41577-019-0245-1

      Commensal human papillomaviruses prime CD8+ T cells that can protect against skin cancer.Nature Reviews Immunology, Published online: 2019-11-08; doi:10.1038/s41577-019-0245-12019-11-08
      DOI: 10.1038/s41577-019-0245-1
  • T cells with fragmented mitochondria frazzle the mind
    • Nature Reviews Immunology, Published online: 07 November 2019; doi:10.1038/s41577-019-0246-0

      Stress-induced metabolic changes in CD4+ T cells linked to anxiety-type behaviours.Nature Reviews Immunology, Published online: 2019-11-07; doi:10.1038/s41577-019-0246-02019-11-07
      DOI: 10.1038/s41577-019-0246-0
  • The gasdermins, a protein family executing cell death and inflammation
    • Nature Reviews Immunology, Published online: 05 November 2019; doi:10.1038/s41577-019-0228-2

      The gasdermin family of proteins has the capacity to form pores in the membrane, causing a pro-inflammatory lytic type of cell death called pyroptosis, This Review provides a comprehensive overview of the gasdermin family, the mechanisms that control their activation and their role in inflammatory disorders and cancer.Nature Reviews Immunology, Published online: 2019-11-05; doi:10.1038/s41577-019-0228-22019-11-05
      DOI: 10.1038/s41577-019-0228-2
  • TIM3 comes of age as an inhibitory receptor
    • Nature Reviews Immunology, Published online: 01 November 2019; doi:10.1038/s41577-019-0224-6

      The co-inhibitory receptor TIM3 can serve as a marker of exhausted T cells. Here, the authors investigate the biology of TIM3, discussing its various ligands, signalling pathways and association with human disease. They also provide an overview of emerging clinical data regarding its potential as an anticancer target in combination with PD1 blockade.Nature Reviews Immunology, Published online: 2019-11-01; doi:10.1038/s41577-019-0224-62019-11-01
      DOI: 10.1038/s41577-019-0224-6
  • Joint effort needed
    • Nature Reviews Immunology, Published online: 30 October 2019; doi:10.1038/s41577-019-0242-4

      Collaboration is key when it comes to mounting an effective T cell response against cancer. A new study shows that CD4+ T cell activation in a tumour is required to support effective priming and cytotoxic activity of tumour-infiltrating CD8+ T cells.Nature Reviews Immunology, Published online: 2019-10-30; doi:10.1038/s41577-019-0242-42019-10-30
      DOI: 10.1038/s41577-019-0242-4
  • Commensal viruses contribute to gut health
    • Nature Reviews Immunology, Published online: 30 October 2019; doi:10.1038/s41577-019-0241-5

      Commensal viruses in the intestine support the proliferation and survival of intraepithelial lymphocytes through RIG-I-dependent IL-15 production and therefore contribute to healthy gut homeostasis.Nature Reviews Immunology, Published online: 2019-10-30; doi:10.1038/s41577-019-0241-52019-10-30
      DOI: 10.1038/s41577-019-0241-5
  • Modulation of innate and adaptive immunity by cytomegaloviruses
    • Nature Reviews Immunology, Published online: 30 October 2019; doi:10.1038/s41577-019-0225-5

      This Review focuses on the cytomegaloviruses and the sophisticated strategies they have evolved to evade immune recognition. The authors suggest a better appreciation of these pathways could have clinical implications beyond antiviral immunity, for instance in understanding immune evasion in cancer.Nature Reviews Immunology, Published online: 2019-10-30; doi:10.1038/s41577-019-0225-52019-10-30
      DOI: 10.1038/s41577-019-0225-5
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