Journal Cover
Nature Reviews Immunology
Journal Prestige (SJR): 28.786
Citation Impact (citeScore): 17
Number of Followers: 288  
 
  Full-text available via subscription Subscription journal
ISSN (Print) 1474-1733 - ISSN (Online) 1474-1741
Published by NPG Homepage  [137 journals]
  • The importance of exosomal PDL1 in tumour immune evasion
    • Nature Reviews Immunology, Published online: 21 January 2020; doi:10.1038/s41577-019-0264-y

      Freeman and colleagues draw our attention to the existence of different forms of PDL1 — cell bound and various extracellular forms. Recent studies show that PDL1 on exosomes can inhibit antitumour immune responses and may be a useful biomarker for the management of cancer immunotherapy.Nature Reviews Immunology, Published online: 2020-01-21; doi:10.1038/s41577-019-0264-y2020-01-21
      DOI: 10.1038/s41577-019-0264-y
       
  • Intercepting bacterial communications
    • Nature Reviews Immunology, Published online: 21 January 2020; doi:10.1038/s41577-020-0278-5

      The host aryl hydrocarbon receptor can detect various quorum-sensing molecules produced by Pseudomonas aeruginosa, which may allow host immune cells to tune their response according to the bacterial density.Nature Reviews Immunology, Published online: 2020-01-21; doi:10.1038/s41577-020-0278-52020-01-21
      DOI: 10.1038/s41577-020-0278-5
       
  • A new life for self-reactive T cell precursors
    • Nature Reviews Immunology, Published online: 20 January 2020; doi:10.1038/s41577-020-0277-6

      Rémy Bosselut describes a 2001 paper by Jordan et al. showing that CD25+ regulatory T cells can be selected on self-peptides, which provided important insights into mechanisms of thymic tolerance.Nature Reviews Immunology, Published online: 2020-01-20; doi:10.1038/s41577-020-0277-62020-01-20
      DOI: 10.1038/s41577-020-0277-6
       
  • Myeloid PD1 in the frame
    • Nature Reviews Immunology, Published online: 14 January 2020; doi:10.1038/s41577-020-0276-7

      T cells expressing programmed cell death 1 (PD1) have been considered the main targets of immune checkpoint blockade therapy. But a new study shows that targeting PD1 on myeloid cells reprogrammes tumour-induced myelopoiesis to favour maturation of effector myeloid cells that promote antitumour immunity.Nature Reviews Immunology, Published online: 2020-01-14; doi:10.1038/s41577-020-0276-72020-01-14
      DOI: 10.1038/s41577-020-0276-7
       
  • Marking true TFH cells
    • Nature Reviews Immunology, Published online: 10 January 2020; doi:10.1038/s41577-020-0273-x

      Hai Qi describes a 2007 paper by Jason Cyster and colleagues that identified PD1 as a marker for T follicular helper cells.Nature Reviews Immunology, Published online: 2020-01-10; doi:10.1038/s41577-020-0273-x2020-01-10
      DOI: 10.1038/s41577-020-0273-x
       
  • Dissecting the mechanisms of immune checkpoint therapy
    • Nature Reviews Immunology, Published online: 10 January 2020; doi:10.1038/s41577-020-0275-8

      Studies of immune checkpoint therapy for cancer in 2019 uncovered critical insights into the differences between targeting CTLA4 versus PD1 and the role of particular T cell subsets in immune responses to cancer. Moreover, reverse translational studies are informing our understanding of resistance and response mechanisms in patients.Nature Reviews Immunology, Published online: 2020-01-10; doi:10.1038/s41577-020-0275-82020-01-10
      DOI: 10.1038/s41577-020-0275-8
       
  • Immunometabolism of infections
    • Nature Reviews Immunology, Published online: 31 December 2019; doi:10.1038/s41577-019-0266-9

      Several studies in 2019 have provided exciting insights into the relationship between the immune response to infection and the host metabolic system.Nature Reviews Immunology, Published online: 2019-12-31; doi:10.1038/s41577-019-0266-92019-12-31
      DOI: 10.1038/s41577-019-0266-9
       
  • Form and function for T cells in health and disease
    • Nature Reviews Immunology, Published online: 30 December 2019; doi:10.1038/s41577-019-0267-8

      In this Year in Review, Donna Farber discusses some of the exciting breakthroughs that occurred in the T cell field in 2019, highlighting the therapeutic implications for our understanding of T cell function in infection, allergy, inflammatory disease and cancer.Nature Reviews Immunology, Published online: 2019-12-30; doi:10.1038/s41577-019-0267-82019-12-30
      DOI: 10.1038/s41577-019-0267-8
       
 
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