Journal Cover
Nature Reviews Genetics
Journal Prestige (SJR): 34.896
Citation Impact (citeScore): 17
Number of Followers: 302  
 
  Full-text available via subscription Subscription journal
ISSN (Print) 1471-0056 - ISSN (Online) 1471-0064
Published by NPG Homepage  [140 journals]
  • Somatic genetic rescue in Mendelian haematopoietic diseases
    • Nature Reviews Genetics, Published online: 11 June 2019; doi:10.1038/s41576-019-0139-x

      Somatic genetic rescue (SGR) occurs when an acquired somatic mutation counteracts the effects of a germline mutation at a cellular level. The increasing number of SGR events reported for Mendelian haematopoietic diseases have important diagnostic, therapeutic and clinical consequences.Nature Reviews Genetics, Published online: 2019-06-11; doi:10.1038/s41576-019-0139-x2019-06-11
      DOI: 10.1038/s41576-019-0139-x
       
  • Genetic correlations of polygenic disease traits: from theory to practice
    • Nature Reviews Genetics, Published online: 06 June 2019; doi:10.1038/s41576-019-0137-z

      In this Review, van Rheenen et al. outline how improved methodologies have enabled genetic correlations to be estimated for almost any trait pair. Genetic correlations can improve our understanding of the shared biology and causal relationships between traits.Nature Reviews Genetics, Published online: 2019-06-06; doi:10.1038/s41576-019-0137-z2019-06-06
      DOI: 10.1038/s41576-019-0137-z
       
  • Fine-tuning mitochondria to the nuclear genome
    • Nature Reviews Genetics, Published online: 06 June 2019; doi:10.1038/s41576-019-0146-y

      A new study in Science identifies strong selective pressure on mitochondrial DNA during transmission through the female germ line, as well as an interplay with the nuclear genome that shapes mitochondrial genetic variation.Nature Reviews Genetics, Published online: 2019-06-06; doi:10.1038/s41576-019-0146-y2019-06-06
      DOI: 10.1038/s41576-019-0146-y
       
  • Chromatin-associated RNAs as facilitators of functional genomic
           interactions
    • Nature Reviews Genetics, Published online: 03 June 2019; doi:10.1038/s41576-019-0135-1

      Enabled by genome-wide profiling approaches, there is growing appreciation for the prevalence and functional importance of various types of chromatin-associated RNAs. As Li and Fu describe in this Review, these RNAs can either be retained in cis at their site of transcription or recruited in cis to other loci, and they have diverse roles in gene regulation, genome organization, nuclear body formation and phase-separation events.Nature Reviews Genetics, Published online: 2019-06-03; doi:10.1038/s41576-019-0135-12019-06-03
      DOI: 10.1038/s41576-019-0135-1
       
  • Author Correction: Challenges in measuring and understanding biological
           noise
    • Nature Reviews Genetics, Published online: 03 June 2019; doi:10.1038/s41576-019-0142-2

      Author Correction: Challenges in measuring and understanding biological noiseNature Reviews Genetics, Published online: 2019-06-03; doi:10.1038/s41576-019-0142-22019-06-03
      DOI: 10.1038/s41576-019-0142-2
       
  • Epigenetic cancer evolution, one cell at a time
    • Nature Reviews Genetics, Published online: 03 June 2019; doi:10.1038/s41576-019-0143-1

      Two recent studies trace epigenetic marks in cells from patients with chronic lymphocytic leukaemia (CLL) to characterize the evolution of the epigenome in cancer.Nature Reviews Genetics, Published online: 2019-06-03; doi:10.1038/s41576-019-0143-12019-06-03
      DOI: 10.1038/s41576-019-0143-1
       
  • Carrier screening for recessive disorders
    • Nature Reviews Genetics, Published online: 29 May 2019; doi:10.1038/s41576-019-0134-2

      This Review discusses the current status of expanded carrier screening, including existing recommendations and limitations. The author reviews the framework that is needed for successful comprehensive carrier screening programmes for all autosomal recessive disorders in various populations.Nature Reviews Genetics, Published online: 2019-05-29; doi:10.1038/s41576-019-0134-22019-05-29
      DOI: 10.1038/s41576-019-0134-2
       
  • Challenges in measuring and understanding biological noise
    • Nature Reviews Genetics, Published online: 21 May 2019; doi:10.1038/s41576-019-0130-6

      Gene expression is subjected to various random processes (referred to as ‘noise’) that contribute to variability in molecular phenotypes. As Eling, Morgan and Marioni describe, there are various challenges to studying this variability, such as disentangling its multilayered sources, distinguishing it from deterministic influences on cellular variability, modelling it with appropriate statistical methods and understanding its practical consequences.Nature Reviews Genetics, Published online: 2019-05-21; doi:10.1038/s41576-019-0130-62019-05-21
      DOI: 10.1038/s41576-019-0130-6
       
 
 
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