Journal Cover
Nature Reviews Genetics
Journal Prestige (SJR): 34.896
Citation Impact (citeScore): 17
Number of Followers: 317  
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ISSN (Print) 1471-0056 - ISSN (Online) 1471-0064
Published by NPG Homepage  [138 journals]
  • Determinants of enhancer and promoter activities of regulatory elements
    • Nature Reviews Genetics, Published online: 11 October 2019; doi:10.1038/s41576-019-0173-8

      Activating transcriptional regulatory elements have traditionally been categorized into promoters, which define transcription start sites, and enhancers, which act distally to stimulate transcription. In this Review, Andersson and Sandelin discuss the latest findings from methodologies for profiling and testing transcriptional regulatory elements at scale. They explain how the data support an updated, nuanced model that accounts for the numerous overlapping molecular properties of promoters and enhancers.Nature Reviews Genetics, Published online: 2019-10-11; doi:10.1038/s41576-019-0173-82019-10-11
      DOI: 10.1038/s41576-019-0173-8
  • Rare-variant collapsing analyses for complex traits: guidelines and
    • Nature Reviews Genetics, Published online: 11 October 2019; doi:10.1038/s41576-019-0177-4

      The increased adoption of DNA sequencing in genetic association studies is uncovering a wide range of population genetic variation, including rare genetic variants. Although this rarity limits the statistical power of associating individual rare variants with phenotypes, this Review discusses the diverse methods for leveraging the collective effects of rare variants in order to uncover important roles in complex traits, particularly human diseases.Nature Reviews Genetics, Published online: 2019-10-11; doi:10.1038/s41576-019-0177-42019-10-11
      DOI: 10.1038/s41576-019-0177-4
  • An adaptive walk in the park
    • Nature Reviews Genetics, Published online: 04 October 2019; doi:10.1038/s41576-019-0182-7

      A study in Nature retraces the convergent evolution of resistance to cardiac glycosides in insects, pinpointing the adaptive alleles and their functional consequences.Nature Reviews Genetics, Published online: 2019-10-04; doi:10.1038/s41576-019-0182-72019-10-04
      DOI: 10.1038/s41576-019-0182-7
  • A sound strategy for gene expression
    • Nature Reviews Genetics, Published online: 02 October 2019; doi:10.1038/s41576-019-0181-8

      A new study in Science reports a synthetic biology approach to encode an ultrasound-based gene expression reporter that is applicable to mammalian cells in vitro and in vivo.Nature Reviews Genetics, Published online: 2019-10-02; doi:10.1038/s41576-019-0181-82019-10-02
      DOI: 10.1038/s41576-019-0181-8
  • Mapping worm embryogenesis
    • Nature Reviews Genetics, Published online: 23 September 2019; doi:10.1038/s41576-019-0179-2

      A study in Science describes the generation of a lineage-resolved single-cell transcriptome atlas for Caenorhabditis elegans embryos. This resource provides insight into the transcriptional changes underlying cell fate decisions.Nature Reviews Genetics, Published online: 2019-09-23; doi:10.1038/s41576-019-0179-22019-09-23
      DOI: 10.1038/s41576-019-0179-2
  • Context is everything: aneuploidy in cancer
    • Nature Reviews Genetics, Published online: 23 September 2019; doi:10.1038/s41576-019-0171-x

      Aneuploidy contributes to tumorigenesis, but the underlying processes are not well understood. This Review explains the context dependency of aneuploidy in cancer and discusses its clinical potential as a prognostic marker and a therapeutic target.Nature Reviews Genetics, Published online: 2019-09-23; doi:10.1038/s41576-019-0171-x2019-09-23
      DOI: 10.1038/s41576-019-0171-x
  • Mechanisms of early placental development in mouse and humans
    • Nature Reviews Genetics, Published online: 18 September 2019; doi:10.1038/s41576-019-0169-4

      This Review summarizes our current understanding of the molecular, genetic and epigenetic regulation of normal placentation, largely based on insights from the mouse model, and outlines the new opportunities provided by recent successes in deriving human trophoblast stem cells.Nature Reviews Genetics, Published online: 2019-09-18; doi:10.1038/s41576-019-0169-42019-09-18
      DOI: 10.1038/s41576-019-0169-4
  • Early-life antibiotic use and gut microbiota
    • Nature Reviews Genetics, Published online: 13 September 2019; doi:10.1038/s41576-019-0174-7

      A recent study in Nature Microbiology reports metagenomic signatures of early-life antibiotic treatment and hospitalization associated with preterm birth that persist long-term.Nature Reviews Genetics, Published online: 2019-09-13; doi:10.1038/s41576-019-0174-72019-09-13
      DOI: 10.1038/s41576-019-0174-7
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