Journal Cover
Nature Reviews Cancer
Journal Prestige (SJR): 23.53
Citation Impact (citeScore): 19
Number of Followers: 227  
  Full-text available via subscription Subscription journal
ISSN (Print) 1474-175X - ISSN (Online) 1474-1768
Published by NPG Homepage  [138 journals]
  • Benevolent viruses in skin cancer
    • Nature Reviews Cancer, Published online: 19 November 2019; doi:10.1038/s41568-019-0229-2

      Strickley, Messerschmidt et al. show that beta human papilloma virus (β-HPV) infection itself is not causal in cutaneous squamous cell carcinoma (SCC) development in the context of immunosuppression — instead, the loss of β-HPV-mediated T cell immunity promotes SCC.Nature Reviews Cancer, Published online: 2019-11-19; doi:10.1038/s41568-019-0229-22019-11-19
      DOI: 10.1038/s41568-019-0229-2
  • KRAS-G12C in the crosshairs
    • Nature Reviews Cancer, Published online: 14 November 2019; doi:10.1038/s41568-019-0228-3

      Two papers report the discovery and preclinical analyses of two different covalent inhibitors of KRAS-G12C (AMG 510 and MRTX849) as well as the first data on the efficacy of these inhibitors in cancer patients.Nature Reviews Cancer, Published online: 2019-11-14; doi:10.1038/s41568-019-0228-32019-11-14
      DOI: 10.1038/s41568-019-0228-3
  • The PI3K–AKT network at the interface of oncogenic signalling and
           cancer metabolism
    • Nature Reviews Cancer, Published online: 04 November 2019; doi:10.1038/s41568-019-0216-7

      This Review discusses the PI3K–AKT signalling network and its control of cancer cell metabolism through both direct and indirect regulation of nutrient transport and metabolic enzymes, thereby connecting oncogenic signalling and metabolic reprogramming to support cancer cell survival and proliferation.Nature Reviews Cancer, Published online: 2019-11-04; doi:10.1038/s41568-019-0216-72019-11-04
      DOI: 10.1038/s41568-019-0216-7
  • Every cell counts
    • Nature Reviews Cancer, Published online: 31 October 2019; doi:10.1038/s41568-019-0225-6

      Research by Chemi at al. highlights the potential of using pulmonary venous circulating tumour cells from patients with NSCLC, collected during tumour resection, to predict relapse and to explore mechanisms of early dissemination.Nature Reviews Cancer, Published online: 2019-10-31; doi:10.1038/s41568-019-0225-62019-10-31
      DOI: 10.1038/s41568-019-0225-6
  • Context-dependent roles of complement in cancer
    • Nature Reviews Cancer, Published online: 30 October 2019; doi:10.1038/s41568-019-0210-0

      This Review discusses the complex and context-dependent role of the complement system in cancer, highlighting the opposing effects of complement activation in both promoting and restraining tumour progression. A novel analysis of publicly available transcriptomic data to provide an overview of the prognostic value of complement gene expression in cancer is also included.Nature Reviews Cancer, Published online: 2019-10-30; doi:10.1038/s41568-019-0210-02019-10-30
      DOI: 10.1038/s41568-019-0210-0
  • Controversies around epithelial–mesenchymal plasticity in cancer
    • Nature Reviews Cancer, Published online: 30 October 2019; doi:10.1038/s41568-019-0213-x

      In this Perspectives article, the authors outline the preclinical and clinical evidence for epithelial–mesenchymal plasticity (EMP) in cancer progression and metastasis, focusing on recent challenges and controversies, and highlight strategies to therapeutically target the EMP process.Nature Reviews Cancer, Published online: 2019-10-30; doi:10.1038/s41568-019-0213-x2019-10-30
      DOI: 10.1038/s41568-019-0213-x
  • The pro-tumorigenic host response to cancer therapies
    • Nature Reviews Cancer, Published online: 23 October 2019; doi:10.1038/s41568-019-0209-6

      To date, studies investigating mechanisms of therapy resistance have primarily focused on tumour-intrinsic changes, yet it is now clear that host responses to different cancer therapies can contribute to tumour regrowth, spread and resistance to therapy. This Review discusses the recent advances in understanding host-mediated pro-tumorigenic responses to cancer therapy, with an emphasis on therapy-induced immunological, angiogenic and metastatic effects.Nature Reviews Cancer, Published online: 2019-10-23; doi:10.1038/s41568-019-0209-62019-10-23
      DOI: 10.1038/s41568-019-0209-6
  • Fungi complements cancer
    • Nature Reviews Cancer, Published online: 15 October 2019; doi:10.1038/s41568-019-0218-5

      The microbiome is more than just bacteria. Now, the groups of Deepak Saxena and George Miller at New York University have linked alterations in the fungal component of the pancreatic microbiome, which activate the complement cascade, to pancreatic ductal adenocarcinoma growth and progressionNature Reviews Cancer, Published online: 2019-10-15; doi:10.1038/s41568-019-0218-52019-10-15
      DOI: 10.1038/s41568-019-0218-5
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