Journal Cover
Nature Reviews Cancer
Journal Prestige (SJR): 23.53
Citation Impact (citeScore): 19
Number of Followers: 223  
 
  Full-text available via subscription Subscription journal
ISSN (Print) 1474-175X - ISSN (Online) 1474-1768
Published by NPG Homepage  [138 journals]
  • Cancer biology as revealed by the research autopsy
    • Nature Reviews Cancer, Published online: 13 September 2019; doi:10.1038/s41568-019-0199-4

      The research autopsy is an underused approach to investigate fundamental questions in cancer biology. This Review discusses the rationale for using research autopsies in cancer research, highlighting how this approach has improved knowledge of cancer biology and its tremendous potential to inform future precision medicine strategies.Nature Reviews Cancer, Published online: 2019-09-13; doi:10.1038/s41568-019-0199-42019-09-13
      DOI: 10.1038/s41568-019-0199-4
       
  • Methionine metabolism in health and cancer: a nexus of diet and precision
           medicine
    • Nature Reviews Cancer, Published online: 12 September 2019; doi:10.1038/s41568-019-0187-8

      Methionine uptake and metabolism contributes to cancer pathogenesis through functions in methylation reactions and one-carbon metabolism. This Review discusses methionine metabolism in the context of nutrition and the potential of targeting methionine metabolism in cancer through dietary or pharmacological intervention.Nature Reviews Cancer, Published online: 2019-09-12; doi:10.1038/s41568-019-0187-82019-09-12
      DOI: 10.1038/s41568-019-0187-8
       
  • Targeting transcription factors in cancer — from undruggable to
           reality
    • Nature Reviews Cancer, Published online: 11 September 2019; doi:10.1038/s41568-019-0196-7

      This Review discusses the various approaches that are being explored to target transcription factors in cancer, with many of the inhibitors developed from such approaches now advancing to early clinical trials.Nature Reviews Cancer, Published online: 2019-09-11; doi:10.1038/s41568-019-0196-72019-09-11
      DOI: 10.1038/s41568-019-0196-7
       
  • Improving cancer immunotherapy through nanotechnology
    • Nature Reviews Cancer, Published online: 06 September 2019; doi:10.1038/s41568-019-0186-9

      Previous nanomedicine approaches have attempted to concentrate the action of cytotoxic therapies at tumours, generally with limited success. This Review discusses how the field is evolving to use nanoparticles and biomaterials to program the location, pharmacokinetics and co-delivery of immunotherapies, eliciting responses that cannot be achieved upon administration of such compounds in solution.Nature Reviews Cancer, Published online: 2019-09-06; doi:10.1038/s41568-019-0186-92019-09-06
      DOI: 10.1038/s41568-019-0186-9
       
  • In vivo T cell CRISPR screens reveal immunotherapeutic targets
    • Nature Reviews Cancer, Published online: 06 September 2019; doi:10.1038/s41568-019-0207-8

      In a study published in Cell, Dong et al. employ a genome-scale CRISPR screening approach to identify both known and previously uncharacterized regulators of CD8+ T cell activity, highlighting the utility of this approach for immunotherapeutic target discovery.Nature Reviews Cancer, Published online: 2019-09-06; doi:10.1038/s41568-019-0207-82019-09-06
      DOI: 10.1038/s41568-019-0207-8
       
  • Changing mindsets
    • Nature Reviews Cancer, Published online: 05 September 2019; doi:10.1038/s41568-019-0204-y

      Beyond the laboratory bench, cancer researchers will face big challenges during their careers. Nature Reviews Cancer has published two Viewpoint articles to highlight some of these wider issues.Nature Reviews Cancer, Published online: 2019-09-05; doi:10.1038/s41568-019-0204-y2019-09-05
      DOI: 10.1038/s41568-019-0204-y
       
  • Phage warriors
    • Nature Reviews Cancer, Published online: 05 September 2019; doi:10.1038/s41568-019-0203-z

      Zheng et al. have developed a phage-guided nanoparticle approach to modulate tumour-associated bacterial species and deliver chemotherapy for local release. This strategy was able to suppress tumour growth in mouse models of colorectal cancer.Nature Reviews Cancer, Published online: 2019-09-05; doi:10.1038/s41568-019-0203-z2019-09-05
      DOI: 10.1038/s41568-019-0203-z
       
  • Nothing to gain for p53
    • Nature Reviews Cancer, Published online: 30 August 2019; doi:10.1038/s41568-019-0202-0

      Boettcher et al. show that missense mutations in the DNA-binding domain of TP53 lead to a dominant-negative effect in leukaemia, where mutant p53, instead of activating de novo transcriptional programmes, inhibits the wild-type protein, thereby driving clonal selection.Nature Reviews Cancer, Published online: 2019-08-30; doi:10.1038/s41568-019-0202-02019-08-30
      DOI: 10.1038/s41568-019-0202-0
       
 
 
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