Journal Cover
Nature Reviews Cancer
Journal Prestige (SJR): 23.53
Citation Impact (citeScore): 19
Number of Followers: 243  
 
  Full-text available via subscription Subscription journal
ISSN (Print) 1474-175X - ISSN (Online) 1474-1768
Published by NPG Homepage  [138 journals]
  • A census of pathway maps in cancer systems biology
    • Nature Reviews Cancer, Published online: 17 February 2020; doi:10.1038/s41568-020-0240-7

      This Analysis surveys several major cancer systems biology approaches with attention to how well their resulting network maps cover, and enhance, our knowledge of cancer pathways.Nature Reviews Cancer, Published online: 2020-02-17; doi:10.1038/s41568-020-0240-72020-02-17
      DOI: 10.1038/s41568-020-0240-7
       
  • Starving tumours
    • Nature Reviews Cancer, Published online: 06 February 2020; doi:10.1038/s41568-020-0244-3

      Ajona et al. have shown that short-term starvation can sensitize lung tumours in mice to the action of immune checkpoint blockade through a reduction in levels of circulating insulin-like growth factor 1 (IGF1).Nature Reviews Cancer, Published online: 2020-02-06; doi:10.1038/s41568-020-0244-32020-02-06
      DOI: 10.1038/s41568-020-0244-3
       
  • CD8+ T cell states in human cancer: insights from single-cell
           analysis
    • Nature Reviews Cancer, Published online: 05 February 2020; doi:10.1038/s41568-019-0235-4

      Recent single-cell RNA-sequencing studies have revealed a range of intratumoural T cell states, both within and between patients. This Review outlines the CD8+ T cell states that have been identified in human tumours and the potential roles they play in tumour control as well as how they are influenced by immune checkpoint blockade.Nature Reviews Cancer, Published online: 2020-02-05; doi:10.1038/s41568-019-0235-42020-02-05
      DOI: 10.1038/s41568-019-0235-4
       
  • Surviving stress during metastasis
    • Nature Reviews Cancer, Published online: 04 February 2020; doi:10.1038/s41568-020-0243-4

      A recent study from Ralph DeBerardinis’ and Sean Morrison’s labs has found that metastatic melanoma cells upregulate the lactate transporter MCT1 in vivo to manage oxidative stress, which allows them to survive during dissemination.Nature Reviews Cancer, Published online: 2020-02-04; doi:10.1038/s41568-020-0243-42020-02-04
      DOI: 10.1038/s41568-020-0243-4
       
  • Cancer disparities
    • Nature Reviews Cancer, Published online: 29 January 2020; doi:10.1038/s41568-020-0242-5

      Sinha et al. systematically mapped genomic alterations in lung tumours from an ethnically unbiased patient cohort and demonstrated a higher frequency of homologous recombination deficiency in tumours from African Americans than European Americans, highlighting the need to include diverse populations in cancer genomics studies.Nature Reviews Cancer, Published online: 2020-01-29; doi:10.1038/s41568-020-0242-52020-01-29
      DOI: 10.1038/s41568-020-0242-5
       
  • A framework for advancing our understanding of cancer-associated
           fibroblasts
    • Nature Reviews Cancer, Published online: 24 January 2020; doi:10.1038/s41568-019-0238-1

      This Consensus Statement highlights the importance of cancer-associated fibroblasts in cancer biology and progression, and issues a call to action for all cancer researchers to standardize assays and report metadata in studies of cancer-associated fibroblasts to advance our understanding of this important cell type in the tumour microenvironment.Nature Reviews Cancer, Published online: 2020-01-24; doi:10.1038/s41568-019-0238-12020-01-24
      DOI: 10.1038/s41568-019-0238-1
       
  • Nerves in cancer
    • Nature Reviews Cancer, Published online: 23 January 2020; doi:10.1038/s41568-019-0237-2

      This Review discusses the role that nerves play in the initiation and progression of cancers, focusing on the evidence that tumours may reactivate nerve-mediated developmental and regenerative pathways to promote their own growth and survival.Nature Reviews Cancer, Published online: 2020-01-23; doi:10.1038/s41568-019-0237-22020-01-23
      DOI: 10.1038/s41568-019-0237-2
       
  • Outcompeting cancer
    • Nature Reviews Cancer, Published online: 13 January 2020; doi:10.1038/s41568-019-0231-8

      This Perspective discusses how cell competition between tumour cells and neighbouring epithelial host cells may dictate tumorigenesis and proposes that manipulating the strength and direction of cell competition could form the basis of an orthogonal therapeutic strategy.Nature Reviews Cancer, Published online: 2020-01-13; doi:10.1038/s41568-019-0231-82020-01-13
      DOI: 10.1038/s41568-019-0231-8
       
 
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