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Journal Cover Nature Neuroscience
  [SJR: 13.558]   [H-I: 325]   [363 followers]  Follow
   Full-text available via subscription Subscription journal
   ISSN (Print) 1097-6256 - ISSN (Online) 1546-1726
   Published by NPG Homepage  [135 journals]
  • Unexpected help to repair the cerebellum
    • Authors: Baptiste N Jaeger, Sebastian Jessberger
      Pages: 1319 - 1321
      Abstract: Upon injury of the developing mouse cerebellum, endogenous repair mechanisms can heal the brain and prevent behavioral motor deficits. At the right time, with the right cues, the brain can repair itself.
      Citation: Nature Neuroscience 20, 1319 (2017)
      PubDate: 2017-09-26
      DOI: 10.1038/nn.4640
      Issue No: Vol. 20, No. 10 (2017)
  • Yummy or yucky' Ask your central amygdala
    • Authors: Yoav Livneh, Mark L Andermann
      Pages: 1321 - 1322
      Abstract: Central amygdala directs behavioral responses to emotionally salient stimuli. While most studies have focused on aversive responses, some central amygdala neurons promote feeding and are positively reinforcing.
      Citation: Nature Neuroscience 20, 1321 (2017)
      PubDate: 2017-09-26
      DOI: 10.1038/nn.4639
      Issue No: Vol. 20, No. 10 (2017)
  • Choosing the right bar: a complex problem
    • Authors: Mai M Morimoto, Aman B Saleem
      Pages: 1323 - 1324
      Abstract: Inputs to the central complex, the navigation center of Drosophila, are strongly modulated by the visual stimulus history. These history effects carry forward to bias turning behavior when flies choose between two visual stimuli.
      Citation: Nature Neuroscience 20, 1323 (2017)
      PubDate: 2017-09-26
      DOI: 10.1038/nn.4646
      Issue No: Vol. 20, No. 10 (2017)
  • Memory reactivation improves visual perception
    • Authors: Rotem Amar-Halpert, Rony Laor-Maayany, Shlomi Nemni, Jonathan D Rosenblatt, Nitzan Censor
      Pages: 1325 - 1328
      Abstract: Human perception can improve through repeated practice, enabling perceptual learning. The authors report findings challenging the fundamental ‘practice makes perfect’ basis of procedural learning theory. They show that brief periods in which visual memory is reactivated are sufficient to improve basic perceptual thresholds, supporting a new account of perceptual learning dynamics.
      Citation: Nature Neuroscience 20, 1325 (2017)
      PubDate: 2017-08-28
      DOI: 10.1038/nn.4629
      Issue No: Vol. 20, No. 10 (2017)
  • AAV-mediated direct in vivo CRISPR screen identifies functional
           suppressors in glioblastoma
    • Authors: Ryan D Chow, Christopher D Guzman, Guangchuan Wang, Florian Schmidt, Mark W Youngblood, Lupeng Ye, Youssef Errami, Matthew B Dong, Michael A Martinez, Sensen Zhang, Paul Renauer, Kaya Bilguvar, Murat Gunel, Phillip A Sharp, Feng Zhang, Randall J Platt, Sidi Chen
      Pages: 1329 - 1341
      Abstract: Using an adeno-associated virus–mediated, direct in vivo CRISPR screen, the authors mapped a quantitative landscape of glioblastoma suppressors. Their study revealed gene combinations that functionally drive gliomagenesis from normal glia in native mouse brains. The authors further demonstrate that mutational background can differentially influence gene expression and chemotherapeutic resistance.
      Citation: Nature Neuroscience 20, 1329 (2017)
      PubDate: 2017-08-14
      DOI: 10.1038/nn.4620
      Issue No: Vol. 20, No. 10 (2017)
  • Analysis of genome-wide association data highlights candidates for drug
           repositioning in psychiatry
    • Authors: Hon-Cheong So, Carlos Kwan-Long Chau, Wan-To Chiu, Kin-Sang Ho, Cho-Pong Lo, Stephanie Ho-Yue Yim, Pak-Chung Sham
      Pages: 1342 - 1349
      Abstract: The authors propose a framework for drug repositioning by comparing GWAS-imputed transcriptomes with drug-induced gene expression profiles. The approach was applied to seven psychiatric disorders. Repositioning candidates were significantly enriched for known psychiatric medications or for therapies considered in clinical trials, supporting a role of GWAS in guiding drug discovery.
      Citation: Nature Neuroscience 20, 1342 (2017)
      PubDate: 2017-08-14
      DOI: 10.1038/nn.4618
      Issue No: Vol. 20, No. 10 (2017)
  • Glia initiate brain assembly through noncanonical Chimaerin–Furin
           axon guidance in C. elegans
    • Authors: Georgia Rapti, Chang Li, Alan Shan, Yun Lu, Shai Shaham
      Pages: 1350 - 1360
      Abstract: Brain self-assembly is thought to be initiated by pioneer neurons whose identity is unknown. Rapti et al., addressing this long-standing mystery, uncover key steps in forming the brain-like nerve ring of C. elegans. Glia initiate the structure, using Netrin to guide pioneer neurons, whose identity is characterized. Glia and pioneer neurons then together direct follower-axon guidance using redundant guidance factors.
      Citation: Nature Neuroscience 20, 1350 (2017)
      PubDate: 2017-08-28
      DOI: 10.1038/nn.4630
      Issue No: Vol. 20, No. 10 (2017)
  • Cerebellar granule cell replenishment postinjury by adaptive reprogramming
           of Nestin+ progenitors
    • Authors: Alexandre Wojcinski, Andrew K Lawton, N Sumru Bayin, Zhimin Lao, Daniel N Stephen, Alexandra L Joyner
      Pages: 1361 - 1370
      Abstract: Recovery of the developing cerebellum after depletion of granule cells, the most plentiful neuron population, depends on adaptive reprogramming of neural progenitors to a new fate and a powerful cell–cell communication system that ensures re-establishment of the correct proportions of different cerebellar cell types and normal circuit formation.
      Citation: Nature Neuroscience 20, 1361 (2017)
      PubDate: 2017-08-14
      DOI: 10.1038/nn.4621
      Issue No: Vol. 20, No. 10 (2017)
  • Microglia turnover with aging and in an Alzheimer's model via long-term in
           vivo single-cell imaging
    • Authors: Petra Füger, Jasmin K Hefendehl, Karthik Veeraraghavalu, Ann-Christin Wendeln, Christine Schlosser, Ulrike Obermüller, Bettina M Wegenast-Braun, Jonas J Neher, Peter Martus, Shinichi Kohsaka, Martin Thunemann, Robert Feil, Sangram S Sisodia, Angelos Skodras, Mathias Jucker
      Pages: 1371 - 1376
      Abstract: Neocortical resident microglia are long-lived cells. Füger et al. report that approximately half of these cells survive for the entire lifespan of a mouse. While microglial proliferation under homeostatic conditions is low, proliferation is increased in a mouse model of Alzheimer's disease.
      Citation: Nature Neuroscience 20, 1371 (2017)
      PubDate: 2017-08-28
      DOI: 10.1038/nn.4631
      Issue No: Vol. 20, No. 10 (2017)
  • Selective inhibitory control of pyramidal neuron ensembles and cortical
           subnetworks by chandelier cells
    • Authors: Jiangteng Lu, Jason Tucciarone, Nancy Padilla-Coreano, Miao He, Joshua A Gordon, Z Josh Huang
      Pages: 1377 - 1383
      Abstract: How GABAergic interneurons regulate segregation and integration among pyramidal cells to separate brain networks remains unclear. In this study, the authors show that subsets of chandelier cells in prelimbic area mediate directional inhibitory control of both local pyramidal neuron ensembles and global cortical subnetworks.
      Citation: Nature Neuroscience 20, 1377 (2017)
      PubDate: 2017-08-21
      DOI: 10.1038/nn.4624
      Issue No: Vol. 20, No. 10 (2017)
  • Central amygdala circuits modulate food consumption through a
           positive-valence mechanism
    • Authors: Amelia M Douglass, Hakan Kucukdereli, Marion Ponserre, Milica Markovic, Jan Gründemann, Cornelia Strobel, Pilar L Alcala Morales, Karl-Klaus Conzelmann, Andreas Lüthi, Rüdiger Klein
      Pages: 1384 - 1394
      Abstract: The amygdala central nucleus (CeA) has been implicated in feeding regulation, but the underlying circuit mechanisms are incompletely understood. The authors show, in mice, that GABAergic serotonin receptor 2a–expressing CeA neurons are active during eating and promote positive reinforcement and food consumption, partly through long-range inhibition of the parabrachial nucleus.
      Citation: Nature Neuroscience 20, 1384 (2017)
      PubDate: 2017-08-21
      DOI: 10.1038/nn.4623
      Issue No: Vol. 20, No. 10 (2017)
  • Parallel encoding of recent visual experience and self-motion during
           navigation in Drosophila
    • Authors: Hiroshi M Shiozaki, Hokto Kazama
      Pages: 1395 - 1403
      Abstract: Animals combine multiple cues to navigate the environment. By performing calcium imaging in fruit flies navigating in a virtual space, the authors show that information about recent visual experience and self-motion is separately encoded in parallel neural pathways in the central brain of Drosophila.
      Citation: Nature Neuroscience 20, 1395 (2017)
      PubDate: 2017-09-04
      DOI: 10.1038/nn.4628
      Issue No: Vol. 20, No. 10 (2017)
  • Seeing faces is necessary for face-domain formation
    • Authors: Michael J Arcaro, Peter F Schade, Justin L Vincent, Carlos R Ponce, Margaret S Livingstone
      Pages: 1404 - 1412
      Abstract: Monkeys, like humans, normally have face domains in inferotemporal cortex; however, monkeys raised without exposure to faces do not develop face patches. Normally reared monkeys, like humans, preferentially look at faces, but face-deprived monkeys do not. These results highlight the importance of early experience for normal sensory and cognitive development.
      Citation: Nature Neuroscience 20, 1404 (2017)
      PubDate: 2017-09-04
      DOI: 10.1038/nn.4635
      Issue No: Vol. 20, No. 10 (2017)
  • Selective attention within the foveola
    • Authors: Martina Poletti, Michele Rucci, Marisa Carrasco
      Pages: 1413 - 1417
      Abstract: New techniques for visually stimulating and stabilizing the retina reveal that humans control covert attentional resources with high precision at the center of gaze. These findings show that fine attentional deployment occurs within the fovea and enhances high-acuity vision.
      Citation: Nature Neuroscience 20, 1413 (2017)
      PubDate: 2017-08-14
      DOI: 10.1038/nn.4622
      Issue No: Vol. 20, No. 10 (2017)
  • An xQTL map integrates the genetic architecture of the human brain's
           transcriptome and epigenome
    • Authors: Bernard Ng, Charles C White, Hans-Ulrich Klein, Solveig K Sieberts, Cristin McCabe, Ellis Patrick, Jishu Xu, Lei Yu, Chris Gaiteri, David A Bennett, Sara Mostafavi, Philip L De Jager
      Pages: 1418 - 1426
      Abstract: This paper reports the availability of a new Resource with RNA-seq, DNA methylation and H3K9Ac QTL results from 411 brain samples. Many xQTL SNPs influence multiple molecular features, and the authors observe epigenetic mediation of eQTLs in some cases. Reanalyzing GWAS with an xQTL-weighted approach detected 20 new CNS disease susceptibility loci.
      Citation: Nature Neuroscience 20, 1418 (2017)
      PubDate: 2017-09-04
      DOI: 10.1038/nn.4632
      Issue No: Vol. 20, No. 10 (2017)
  • Corrigendum: L1-associated genomic regions are deleted in somatic cells of
           the healthy human brain
    • Nature Neuroscience 20, 1427 (2017). doi:10.1038/nn1017-1427a

      Author: Jennifer A Erwin, Apuã C M Paquola, Tatjana Singer, Iryna Gallina, Mark Novotny, Carolina Quayle, Tracy A Bedrosian, Francisco I A Alves, Cheyenne R Butcher, Joseph R Herdy, Anindita Sarkar, Roger S Lasken, Alysson R Muotri & Fred H Gage

      Nature Neuroscience 20, 1427 (2017)2017-09-28
      DOI: 10.1038/nn1017-1427a
      Issue No: Vol. 20, No. 10 (2017)
  • Corrigendum: Overlearning hyperstabilizes a skill by rapidly making
           neurochemical processing inhibitory-dominant
    • Nature Neuroscience 20, 1427 (2017). doi:10.1038/nn1017-1427b

      Author: Kazuhisa Shibata, Yuka Sasaki, Ji Won Bang, Edward G Walsh, Maro G Machizawa, Masako Tamaki, Li-Hung Chang & Takeo Watanabe

      Nature Neuroscience 20, 1427 (2017)2017-09-28
      DOI: 10.1038/nn1017-1427b
      Issue No: Vol. 20, No. 10 (2017)
  • Corrigendum: Hormonal gain control of a medial preoptic area social reward
    • Nature Neuroscience 20, 1427 (2017). doi:10.1038/nn1017-1427c

      Author: Jenna A McHenry, James M Otis, Mark A Rossi, J Elliott Robinson, Oksana Kosyk, Noah W Miller, Zoe A McElligott, Evgeny A Budygin, David R Rubinow & Garret D Stuber

      Nature Neuroscience 20, 1427 (2017)2017-09-28
      DOI: 10.1038/nn1017-1427c
      Issue No: Vol. 20, No. 10 (2017)
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