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Journal Cover Nature Neuroscience
  [SJR: 13.558]   [H-I: 325]   [385 followers]  Follow
    
   Full-text available via subscription Subscription journal
   ISSN (Print) 1097-6256 - ISSN (Online) 1546-1726
   Published by NPG Homepage  [135 journals]
  • Genome-wide association study of delay discounting in 23,217 adult
           research participants of European ancestry
    • Genome-wide association study of delay discounting in 23,217 adult research participants of European ancestry

      Genome-wide association study of delay discounting in 23,217 adult research participants of European ancestry, Published online: 11 December 2017; doi:10.1038/s41593-017-0032-x

      A genome-wide association study of delay discounting (DD) on 23,127 subjects found that genotype accounted for 12% of variance in DD; the DD genetic signature overlapped with ADHD, schizophrenia, depression, smoking, personality, cognition and weight.Genome-wide association study of delay discounting in 23,217 adult research participants of European ancestry, Published online: 2017-12-11; doi:10.1038/s41593-017-0032-x2017-12-11
      DOI: 10.1038/s41593-017-0032-x
       
  • Single-cell analysis of experience-dependent transcriptomic states in the
           mouse visual cortex
    • Single-cell analysis of experience-dependent transcriptomic states in the mouse visual cortex

      Single-cell analysis of experience-dependent transcriptomic states in the mouse visual cortex, Published online: 11 December 2017; doi:10.1038/s41593-017-0029-5

      Using single-cell RNA-sequencing, the authors record snapshots of the dynamic sensory-experience-dependent transcriptome across all cell types of the visual cortex in mice exposed to a light stimulus. The authors note diverse cell-type-specific programs in pyramidal neuron subtypes and robust non-neuronal responses that may regulate experience-dependent neurovascular coupling and myelination.Single-cell analysis of experience-dependent transcriptomic states in the mouse visual cortex, Published online: 2017-12-11; doi:10.1038/s41593-017-0029-52017-12-11
      DOI: 10.1038/s41593-017-0029-5
       
  • Integration of grid maps in merged environments
    • Integration of grid maps in merged environments

      Integration of grid maps in merged environments, Published online: 11 December 2017; doi:10.1038/s41593-017-0036-6

      The authors investigate grid cell dynamics after removal of a border between two environments. Near the transition between environments, grid fields changed location, resulting in local spatial periodicity and continuity between the original maps.Integration of grid maps in merged environments, Published online: 2017-12-11; doi:10.1038/s41593-017-0036-62017-12-11
      DOI: 10.1038/s41593-017-0036-6
       
  • Impaired path integration in mice with disrupted grid cell firing
    • Impaired path integration in mice with disrupted grid cell firing

      Impaired path integration in mice with disrupted grid cell firing, Published online: 11 December 2017; doi:10.1038/s41593-017-0039-3

      Grid cell activity may subserve path integration, but a direct link is lacking. The authors selectively disrupt retro-hippocampal region grid cell activity and show that disrupted grid cell firing impairs performance in a path integration task.Impaired path integration in mice with disrupted grid cell firing, Published online: 2017-12-11; doi:10.1038/s41593-017-0039-32017-12-11
      DOI: 10.1038/s41593-017-0039-3
       
  • The C-terminal tails of endogenous GluA1 and GluA2 differentially
           contribute to hippocampal synaptic plasticity and learning
    • The C-terminal tails of endogenous GluA1 and GluA2 differentially contribute to hippocampal synaptic plasticity and learning

      The C-terminal tails of endogenous GluA1 and GluA2 differentially contribute to hippocampal synaptic plasticity and learning, Published online: 11 December 2017; doi:10.1038/s41593-017-0030-z

      Long-lasting synaptic plasticity is regarded as a mechanism for learning and memory. Using genetically engineered mice in which the C-terminal domains of AMPA receptor subtypes are switched, the authors reveal that GluA1 and GluA2 differentially regulate synaptic plasticity and contribute to different forms of learning.The C-terminal tails of endogenous GluA1 and GluA2 differentially contribute to hippocampal synaptic plasticity and learning, Published online: 2017-12-11; doi:10.1038/s41593-017-0030-z2017-12-11
      DOI: 10.1038/s41593-017-0030-z
       
  • Synaptic weight set by Munc13-1 supramolecular assemblies
    • Synaptic weight set by Munc13-1 supramolecular assemblies

      Synaptic weight set by Munc13-1 supramolecular assemblies, Published online: 11 December 2017; doi:10.1038/s41593-017-0041-9

      The authors show that Munc13-1 molecules form multiple supramolecular self-assemblies that serve as vesicular release sites. Having multiple Munc13-1 assemblies affords a stable synaptic weight, which confers robustness of synaptic computation.Synaptic weight set by Munc13-1 supramolecular assemblies, Published online: 2017-12-11; doi:10.1038/s41593-017-0041-92017-12-11
      DOI: 10.1038/s41593-017-0041-9
       
  • Ca 2+ activity signatures of myelin sheath formation and growth in vivo
    • Ca 2+ activity signatures of myelin sheath formation and growth in vivo

      Ca 2+ activity signatures of myelin sheath formation and growth in vivo , Published online: 11 December 2017; doi:10.1038/s41593-017-0040-x

      The authors live-image zebrafish myelin sheath Ca2+ activity in vivo and find that high-amplitude long-duration Ca2+ transients precede calpain-dependent sheath retractions while frequent low-amplitude short-duration transients drive sheath growth.Ca 2+ activity signatures of myelin sheath formation and growth in vivo , Published online: 2017-12-11; doi:10.1038/s41593-017-0040-x2017-12-11
      DOI: 10.1038/s41593-017-0040-x
       
  • Synaptotagmin-1 drives synchronous Ca2+-triggered fusion by
           C2B-domain-mediated synaptic-vesicle-membrane attachment
    • Synaptotagmin-1 drives synchronous Ca2+-triggered fusion by C2B-domain-mediated synaptic-vesicle-membrane attachment

      Synaptotagmin-1 drives synchronous Ca2+-triggered fusion by C2B-domain-mediated synaptic-vesicle-membrane attachment, Published online: 11 December 2017; doi:10.1038/s41593-017-0037-5

      Synaptotagmin-1 (Syt1) controls synaptic vesicle–membrane attachment activities via its C2B domain. These correlate with release synchronization and synaptic short-term facilitation, revealing a mechanism for Syt1-mediated synchronous release.Synaptotagmin-1 drives synchronous Ca2+-triggered fusion by C2B-domain-mediated synaptic-vesicle-membrane attachment, Published online: 2017-12-11; doi:10.1038/s41593-017-0037-52017-12-11
      DOI: 10.1038/s41593-017-0037-5
       
 
 
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