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Journal Cover Nature Neuroscience
  [SJR: 13.558]   [H-I: 325]   [404 followers]  Follow
    
   Full-text available via subscription Subscription journal
   ISSN (Print) 1097-6256 - ISSN (Online) 1546-1726
   Published by NPG Homepage  [135 journals]
  • Repopulated microglia are solely derived from the proliferation of
           residual microglia after acute depletion
    • Repopulated microglia are solely derived from the proliferation of residual microglia after acute depletion

      Repopulated microglia are solely derived from the proliferation of residual microglia after acute depletion, Published online: 22 February 2018; doi:10.1038/s41593-018-0090-8

      Microglia show remarkable regenerative capacity after acute depletion, which had been thought to be derived from de novo progenitors. Peng and colleagues demonstrate that the newly formed microglia are actually solely derived from residual microglia.Repopulated microglia are solely derived from the proliferation of residual microglia after acute depletion, Published online: 2018-02-22; doi:10.1038/s41593-018-0090-82018-02-22
      DOI: 10.1038/s41593-018-0090-8
       
  • Microglia-mediated recovery from ALS-relevant motor neuron degeneration in
           a mouse model of TDP-43 proteinopathy
    • Microglia-mediated recovery from ALS-relevant motor neuron degeneration in a mouse model of TDP-43 proteinopathy

      Microglia-mediated recovery from ALS-relevant motor neuron degeneration in a mouse model of TDP-43 proteinopathy, Published online: 20 February 2018; doi:10.1038/s41593-018-0083-7

      Using an inducible mouse model of sporadic ALS, Spiller et al. show that spinal microgliosis is not a major feature of TDP-43-triggered disease. Instead, microglia mediate TDP-43 clearance and motor recovery, suggesting a neuroprotective role in ALS.Microglia-mediated recovery from ALS-relevant motor neuron degeneration in a mouse model of TDP-43 proteinopathy, Published online: 2018-02-20; doi:10.1038/s41593-018-0083-72018-02-20
      DOI: 10.1038/s41593-018-0083-7
       
  • Shared neural coding for social hierarchy and reward value in primate
           amygdala
    • Shared neural coding for social hierarchy and reward value in primate amygdala

      Shared neural coding for social hierarchy and reward value in primate amygdala, Published online: 19 February 2018; doi:10.1038/s41593-018-0082-8

      New data reveal that the amygdala—a brain area specialized for emotion—also signals the hierarchical rank of peers in a social group. These neural signals likely mediate appropriate social and emotional behavior in many social settings.Shared neural coding for social hierarchy and reward value in primate amygdala, Published online: 2018-02-19; doi:10.1038/s41593-018-0082-82018-02-19
      DOI: 10.1038/s41593-018-0082-8
       
  • Single excitatory axons form clustered synapses onto CA1 pyramidal cell
           dendrites
    • Single excitatory axons form clustered synapses onto CA1 pyramidal cell dendrites

      Single excitatory axons form clustered synapses onto CA1 pyramidal cell dendrites, Published online: 19 February 2018; doi:10.1038/s41593-018-0084-6

      Bloss et al. show single axons form clustered inputs onto the dendrites of hippocampal pyramidal cells in a projection-specific manner. The spatial and temporal features inherent in these connections efficiently drive dendritic depolarization.Single excitatory axons form clustered synapses onto CA1 pyramidal cell dendrites, Published online: 2018-02-19; doi:10.1038/s41593-018-0084-62018-02-19
      DOI: 10.1038/s41593-018-0084-6
       
  • Memory formation depends on both synapse-specific modifications of
           synaptic strength and cell-specific increases in excitability
    • Memory formation depends on both synapse-specific modifications of synaptic strength and cell-specific increases in excitability

      Memory formation depends on both synapse-specific modifications of synaptic strength and cell-specific increases in excitability, Published online: 12 February 2018; doi:10.1038/s41593-018-0076-6

      The authors discuss newly emerging evidence for the role of the transcription factor CREB in memory, including its role in modulating changes in excitability that are critical for neural assembly formation and linking of memories across time.Memory formation depends on both synapse-specific modifications of synaptic strength and cell-specific increases in excitability, Published online: 2018-02-12; doi:10.1038/s41593-018-0076-62018-02-12
      DOI: 10.1038/s41593-018-0076-6
       
  • Single-nucleus analysis of accessible chromatin in developing mouse
           forebrain reveals cell-type-specific transcriptional regulation
    • Single-nucleus analysis of accessible chromatin in developing mouse forebrain reveals cell-type-specific transcriptional regulation

      Single-nucleus analysis of accessible chromatin in developing mouse forebrain reveals cell-type-specific transcriptional regulation, Published online: 12 February 2018; doi:10.1038/s41593-018-0079-3

      This study describes single-nucleus ATAC-seq, a method to profile open chromatin in individual nuclei from frozen tissues. It is used to examine gene regulation in 15,000 nuclei comprising 20 distinct cell types in the developing mouse forebrain.Single-nucleus analysis of accessible chromatin in developing mouse forebrain reveals cell-type-specific transcriptional regulation, Published online: 2018-02-12; doi:10.1038/s41593-018-0079-32018-02-12
      DOI: 10.1038/s41593-018-0079-3
       
  • Bidirectional and long-lasting control of alcohol-seeking behavior by
           corticostriatal LTP and LTD
    • Bidirectional and long-lasting control of alcohol-seeking behavior by corticostriatal LTP and LTD

      Bidirectional and long-lasting control of alcohol-seeking behavior by corticostriatal LTP and LTD, Published online: 12 February 2018; doi:10.1038/s41593-018-0081-9

      Addiction-related behaviors are believed to result from drug-evoked synaptic changes, but their causality is unclear. The authors show that bidirectional optogenetic modifications of synaptic strength distinctly alter alcohol-seeking behavior.Bidirectional and long-lasting control of alcohol-seeking behavior by corticostriatal LTP and LTD, Published online: 2018-02-12; doi:10.1038/s41593-018-0081-92018-02-12
      DOI: 10.1038/s41593-018-0081-9
       
  • Striatal neurons directly converted from Huntington’s disease patient
           fibroblasts recapitulate age-associated disease phenotypes
    • Striatal neurons directly converted from Huntington’s disease patient fibroblasts recapitulate age-associated disease phenotypes

      Striatal neurons directly converted from Huntington’s disease patient fibroblasts recapitulate age-associated disease phenotypes, Published online: 05 February 2018; doi:10.1038/s41593-018-0075-7

      Direct neuronal conversion of skin fibroblasts from individuals with Huntington’s disease (HD) generates a population of medium spiny neurons that recapitulate hallmarks of HD, including aggregation of mutant huntingtin protein, DNA damage and spontaneous cell death.Striatal neurons directly converted from Huntington’s disease patient fibroblasts recapitulate age-associated disease phenotypes, Published online: 2018-02-05; doi:10.1038/s41593-018-0075-72018-02-05
      DOI: 10.1038/s41593-018-0075-7
       
 
 
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