Journal Cover Nature Methods
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   ISSN (Print) 1548-7091 - ISSN (Online) 1548-7105
   Published by NPG Homepage  [142 journals]
  • Mapping the physical network of cellular interactions
    • Mapping the physical network of cellular interactions

      Mapping the physical network of cellular interactions, Published online: 21 May 2018; doi:10.1038/s41592-018-0009-z

      The ProximID approach generates single-cell expression profiles and a network of enriched physical cellular interactions within a tissue.Mapping the physical network of cellular interactions, Published online: 2018-05-21; doi:10.1038/s41592-018-0009-z2018-05-21
      DOI: 10.1038/s41592-018-0009-z
       
  • CRISPR off-target analysis in genetically engineered rats and mice
    • CRISPR off-target analysis in genetically engineered rats and mice

      CRISPR off-target analysis in genetically engineered rats and mice, Published online: 21 May 2018; doi:10.1038/s41592-018-0011-5

      Off-targets identified by whole-genome sequencing of CRISPR-treated mouse embryos and their genetic parents are compared to predictions from GUIDE-seq and computational methods.CRISPR off-target analysis in genetically engineered rats and mice, Published online: 2018-05-21; doi:10.1038/s41592-018-0011-52018-05-21
      DOI: 10.1038/s41592-018-0011-5
       
  • Automated, parallel mass spectrometry imaging and structural
           identification of lipids
    • Automated, parallel mass spectrometry imaging and structural identification of lipids

      Automated, parallel mass spectrometry imaging and structural identification of lipids, Published online: 21 May 2018; doi:10.1038/s41592-018-0010-6

      An automated method coupling tandem mass spectrometry with high-resolution mass spectrometry imaging simultaneously reveals both the molecular structure of lipids and their spatial locations in tissue.Automated, parallel mass spectrometry imaging and structural identification of lipids, Published online: 2018-05-21; doi:10.1038/s41592-018-0010-62018-05-21
      DOI: 10.1038/s41592-018-0010-6
       
  • Author Correction: High-speed volumetric imaging of neuronal activity in
           freely moving rodents
    • Author Correction: High-speed volumetric imaging of neuronal activity in freely moving rodents

      Author Correction: High-speed volumetric imaging of neuronal activity in freely moving rodents, Published online: 21 May 2018; doi:10.1038/s41592-018-0034-y

      Author Correction: High-speed volumetric imaging of neuronal activity in freely moving rodentsAuthor Correction: High-speed volumetric imaging of neuronal activity in freely moving rodents, Published online: 2018-05-21; doi:10.1038/s41592-018-0034-y2018-05-21
      DOI: 10.1038/s41592-018-0034-y
       
  • Single-shot super-resolution total internal reflection fluorescence
           microscopy
    • Single-shot super-resolution total internal reflection fluorescence microscopy

      Single-shot super-resolution total internal reflection fluorescence microscopy, Published online: 07 May 2018; doi:10.1038/s41592-018-0004-4

      Instant structured illumination and total internal reflection fluorescence microscopy are combined to carry out time-lapse super-resolution TIRF imaging at frame rates up to 100 Hz, enabling observation of fast biological processes.Single-shot super-resolution total internal reflection fluorescence microscopy, Published online: 2018-05-07; doi:10.1038/s41592-018-0004-42018-05-07
      DOI: 10.1038/s41592-018-0004-4
       
  • Discovery of proteins associated with a predefined genomic locus via
           dCas9–APEX-mediated proximity labeling
    • Discovery of proteins associated with a predefined genomic locus via dCas9–APEX-mediated proximity labeling

      Discovery of proteins associated with a predefined genomic locus via dCas9–APEX-mediated proximity labeling, Published online: 07 May 2018; doi:10.1038/s41592-018-0007-1

      After CRISPR-mediated targeting of the peroxidase APEX2 to a genomic locus of interest, the proteins at that locus are labeled, enriched and identified via quantitative proteomics.Discovery of proteins associated with a predefined genomic locus via dCas9–APEX-mediated proximity labeling, Published online: 2018-05-07; doi:10.1038/s41592-018-0007-12018-05-07
      DOI: 10.1038/s41592-018-0007-1
       
  • High-speed volumetric imaging of neuronal activity in freely moving
           rodents
    • High-speed volumetric imaging of neuronal activity in freely moving rodents

      High-speed volumetric imaging of neuronal activity in freely moving rodents, Published online: 07 May 2018; doi:10.1038/s41592-018-0008-0

      A miniature light-field microscope in combination with a signal-extraction approach enables high-speed volumetric calcium imaging in freely moving mice.High-speed volumetric imaging of neuronal activity in freely moving rodents, Published online: 2018-05-07; doi:10.1038/s41592-018-0008-02018-05-07
      DOI: 10.1038/s41592-018-0008-0
       
  • BoxCar acquisition method enables single-shot proteomics at a depth of
           10,000 proteins in 100 minutes
    • BoxCar acquisition method enables single-shot proteomics at a depth of 10,000 proteins in 100 minutes

      BoxCar acquisition method enables single-shot proteomics at a depth of 10,000 proteins in 100 minutes, Published online: 07 May 2018; doi:10.1038/s41592-018-0003-5

      BoxCar, a mass spectrometry data acquisition method, greatly increases sensitivity and the detection of low-abundance peptides with a minimal amount of instrument time.BoxCar acquisition method enables single-shot proteomics at a depth of 10,000 proteins in 100 minutes, Published online: 2018-05-07; doi:10.1038/s41592-018-0003-52018-05-07
      DOI: 10.1038/s41592-018-0003-5
       
 
 
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