Journal Cover Nature Medicine
  [SJR: 13.959]   [H-I: 439]   [747 followers]  Follow
    
   Full-text available via subscription Subscription journal
   ISSN (Print) 1078-8956 - ISSN (Online) 1546-170X
   Published by NPG Homepage  [143 journals]
  • Resetting the epigenetic balance of Polycomb and COMPASS function at
           enhancers for cancer therapy
    • Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy

      Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy, Published online: 21 May 2018; doi:10.1038/s41591-018-0034-6

      Interactions between the MLL3 histone methyltransferase and the BAP1–UTX complex set the level of histone H3K27 methylation and suggest a new therapy for MLL3-mutant cancer.Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy, Published online: 2018-05-21; doi:10.1038/s41591-018-0034-62018-05-21
      DOI: 10.1038/s41591-018-0034-6
       
  • Targeting G-quadruplex DNA as cognitive function therapy for ATR-X
           syndrome
    • Targeting G-quadruplex DNA as cognitive function therapy for ATR-X syndrome

      Targeting G-quadruplex DNA as cognitive function therapy for ATR-X syndrome, Published online: 21 May 2018; doi:10.1038/s41591-018-0018-6

      In a mouse model of intellectual disability, the chromatin remodeling protein ATR-X is shown to bind to G-quadruplex DNA structures and modulate target gene expression, which can be pharmacologically targeted to restore neuronal and cognitive phenotypes in these animals.Targeting G-quadruplex DNA as cognitive function therapy for ATR-X syndrome, Published online: 2018-05-21; doi:10.1038/s41591-018-0018-62018-05-21
      DOI: 10.1038/s41591-018-0018-6
       
  • HIV vaccine candidate activation of hypoxia and the inflammasome in CD14+
           monocytes is associated with a decreased risk of SIVmac251 acquisition
    • HIV vaccine candidate activation of hypoxia and the inflammasome in CD14+ monocytes is associated with a decreased risk of SIVmac251 acquisition

      HIV vaccine candidate activation of hypoxia and the inflammasome in CD14+ monocytes is associated with a decreased risk of SIVmac251 acquisition, Published online: 21 May 2018; doi:10.1038/s41591-018-0025-7

      Distinct monocyte subsets associate with different outcomes of SIV vaccines.HIV vaccine candidate activation of hypoxia and the inflammasome in CD14+ monocytes is associated with a decreased risk of SIVmac251 acquisition, Published online: 2018-05-21; doi:10.1038/s41591-018-0025-72018-05-21
      DOI: 10.1038/s41591-018-0025-7
       
  • An immune-beige adipocyte communication via nicotinic acetylcholine
           receptor signaling
    • An immune-beige adipocyte communication via nicotinic acetylcholine receptor signaling

      An immune-beige adipocyte communication via nicotinic acetylcholine receptor signaling, Published online: 21 May 2018; doi:10.1038/s41591-018-0032-8

      Inhibition of immune cell–derived acetylcholine synthesis or of its signaling via CHRNA2 in beige adipocytes reduces thermogenesis and exacerbates diet-induced obesity, suggesting a new mode of immuno–fat communication in energy metabolism.An immune-beige adipocyte communication via nicotinic acetylcholine receptor signaling, Published online: 2018-05-21; doi:10.1038/s41591-018-0032-82018-05-21
      DOI: 10.1038/s41591-018-0032-8
       
  • The reference epigenome and regulatory chromatin landscape of chronic
           lymphocytic leukemia
    • The reference epigenome and regulatory chromatin landscape of chronic lymphocytic leukemia

      The reference epigenome and regulatory chromatin landscape of chronic lymphocytic leukemia, Published online: 21 May 2018; doi:10.1038/s41591-018-0028-4

      An integrated resource of (epi)genomic features in annotated chronic lymphocytic leukemia (CLL) primary samples uncovers subgroup-specific regulatory alterations associated with clinical behavior.The reference epigenome and regulatory chromatin landscape of chronic lymphocytic leukemia, Published online: 2018-05-21; doi:10.1038/s41591-018-0028-42018-05-21
      DOI: 10.1038/s41591-018-0028-4
       
  • Targeting skeletal endothelium to ameliorate bone loss
    • Targeting skeletal endothelium to ameliorate bone loss

      Targeting skeletal endothelium to ameliorate bone loss, Published online: 21 May 2018; doi:10.1038/s41591-018-0020-z

      Recombinant SLIT3 represents a new mechanistic approach to treating osteoporosis by increasing skeletal CD31hiEMCNhi vascular endothelium.Targeting skeletal endothelium to ameliorate bone loss, Published online: 2018-05-21; doi:10.1038/s41591-018-0020-z2018-05-21
      DOI: 10.1038/s41591-018-0020-z
       
  • Elevated prenatal anti-Müllerian hormone reprograms the fetus and induces
           polycystic ovary syndrome in adulthood
    • Elevated prenatal anti-Müllerian hormone reprograms the fetus and induces polycystic ovary syndrome in adulthood

      Elevated prenatal anti-Müllerian hormone reprograms the fetus and induces polycystic ovary syndrome in adulthood, Published online: 14 May 2018; doi:10.1038/s41591-018-0035-5

      Excess anti-Müllerian hormone during pregnancy results in polycystic ovary syndrome-like phenotypes in female offspring, possibly explaining its pathogenesis as well as suggesting a possible therapy.Elevated prenatal anti-Müllerian hormone reprograms the fetus and induces polycystic ovary syndrome in adulthood, Published online: 2018-05-14; doi:10.1038/s41591-018-0035-52018-05-14
      DOI: 10.1038/s41591-018-0035-5
       
  • CAR T cells for childhood diffuse midline gliomas
    • CAR T cells for childhood diffuse midline gliomas

      CAR T cells for childhood diffuse midline gliomas, Published online: 07 May 2018; doi:10.1038/s41591-018-0031-9

      Anti-GD2 chimeric antigen receptor (CAR)-modified T cells may be a new and innovative approach for the treatment of pediatric H3-K27M-mutant diffuse midline gliomas.CAR T cells for childhood diffuse midline gliomas, Published online: 2018-05-07; doi:10.1038/s41591-018-0031-92018-05-07
      DOI: 10.1038/s41591-018-0031-9
       
 
 
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