Journal Cover Nature Medicine
  [SJR: 13.959]   [H-I: 439]   [738 followers]  Follow
    
   Full-text available via subscription Subscription journal
   ISSN (Print) 1078-8956 - ISSN (Online) 1546-170X
   Published by NPG Homepage  [135 journals]
  • H3B-8800, an orally available small-molecule splicing modulator, induces
           lethality in spliceosome-mutant cancers
    • H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers

      H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers, Published online: 19 February 2018; doi:10.1038/nm.4493

      The small molecule H3B-8800 selectively modulates RNA splicing to preferentially kill tumor cells bearing mutations in genes encoding spliceosome components.H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers, Published online: 2018-02-19; doi:10.1038/nm.44932018-02-19
      DOI: 10.1038/nm.4493
       
  • DKK2 imparts tumor immunity evasion through β-catenin-independent
           suppression of cytotoxic immune-cell activation
    • DKK2 imparts tumor immunity evasion through β-catenin-independent suppression of cytotoxic immune-cell activation

      DKK2 imparts tumor immunity evasion through β-catenin-independent suppression of cytotoxic immune-cell activation, Published online: 12 February 2018; doi:10.1038/nm.4496

      A negative regulator of the Wnt pathway secreted by tumor cells promotes immune evasion by suppressing lymphocyte cytotoxicity.DKK2 imparts tumor immunity evasion through β-catenin-independent suppression of cytotoxic immune-cell activation, Published online: 2018-02-12; doi:10.1038/nm.44962018-02-12
      DOI: 10.1038/nm.4496
       
  • Transcriptional regulation of macrophage cholesterol efflux and
           atherogenesis by a long noncoding RNA
    • Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA

      Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA, Published online: 12 February 2018; doi:10.1038/nm.4479

      The conserved long noncoding RNA MeXis has anti-atherosclerotic effects in mice by acting with the nuclear hormone receptor LXR in macrophages to promote cholesterol efflux.Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA, Published online: 2018-02-12; doi:10.1038/nm.44792018-02-12
      DOI: 10.1038/nm.4479
       
  • A histone deacetylase 3–dependent pathway delimits peripheral myelin
           growth and functional regeneration
    • A histone deacetylase 3–dependent pathway delimits peripheral myelin growth and functional regeneration

      A histone deacetylase 3–dependent pathway delimits peripheral myelin growth and functional regeneration, Published online: 12 February 2018; doi:10.1038/nm.4483

      Screening for small-molecule epigenetic modulators identifies HDAC3 inhibitors that promote peripheral myelin repair after nerve injury in rodents.A histone deacetylase 3–dependent pathway delimits peripheral myelin growth and functional regeneration, Published online: 2018-02-12; doi:10.1038/nm.44832018-02-12
      DOI: 10.1038/nm.4483
       
  • Sorafenib promotes graft-versus-leukemia activity in mice and humans
           through IL-15 production in FLT3-ITD-mutant leukemia cells
    • Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells

      Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells, Published online: 12 February 2018; doi:10.1038/nm.4484

      Combining the kinase inhibitor sorafenib with allogeneic stem cell transplantation boosts immune responses against a subtype of acute myelogenous leukemia, suggesting potential clinical benefit.Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells, Published online: 2018-02-12; doi:10.1038/nm.44842018-02-12
      DOI: 10.1038/nm.4484
       
  • Taking personalized medicine to heart
    • Taking personalized medicine to heart

      Taking personalized medicine to heart, Published online: 07 February 2018; doi:10.1038/nm.4495

      Tailoring treatment to the individual patient has revolutionized cancer therapy, but personalized medicine has yet to make much headway in the treatment of cardiovascular disease. With emerging insight into disease mechanisms and new treatment options, the time is now ripe for the cardiovascular field to adopt a more personalized approach to therapy.Taking personalized medicine to heart, Published online: 2018-02-07; doi:10.1038/nm.44952018-02-07
      DOI: 10.1038/nm.4495
       
  • Macrophages and platelets join forces to release kidney-damaging DNA traps
    • Macrophages and platelets join forces to release kidney-damaging DNA traps

      Macrophages and platelets join forces to release kidney-damaging DNA traps, Published online: 07 February 2018; doi:10.1038/nm.4486

      A recent study in mice dissects the mechanisms through which muscle damage leads to kidney dysfunction and identifies macrophage extracellular trap (MET) formation as a new pathogenic driver and potential therapeutic target.Macrophages and platelets join forces to release kidney-damaging DNA traps, Published online: 2018-02-07; doi:10.1038/nm.44862018-02-07
      DOI: 10.1038/nm.4486
       
  • A new vaccine for tuberculosis in rhesus macaques
    • A new vaccine for tuberculosis in rhesus macaques

      A new vaccine for tuberculosis in rhesus macaques, Published online: 07 February 2018; doi:10.1038/nm.4488

      In a recent study using cytomegalovirus (CMV)-vectored vaccines in rhesus macaques, prevention of tuberculosis in over 40% of vaccinated animals is shown and is attributed to reprogrammed innate immunity and CMV's maintenance of vaccine-elicited effector memory T cells.A new vaccine for tuberculosis in rhesus macaques, Published online: 2018-02-07; doi:10.1038/nm.44882018-02-07
      DOI: 10.1038/nm.4488
       
 
 
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