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Journal Cover Nature Genetics
  [SJR: 23.762]   [H-I: 469]   [471 followers]  Follow
    
   Full-text available via subscription Subscription journal
   ISSN (Print) 1061-4036 - ISSN (Online) 1546-1718
   Published by NPG Homepage  [135 journals]
  • A quantitative genetic framework highlights the role of epistatic effects
           for grain-yield heterosis in bread wheat
    • A quantitative genetic framework highlights the role of epistatic effects for grain-yield heterosis in bread wheat

      Nature Genetics, Published online: 16 October 2017; doi:10.1038/ng.3974

      Analysis of a large bread-wheat genomic data set through a quantitative genetic framework designed to study the genetic basis of heterosis shows that hybrids outperform midparents in grain yield by 10%. Genome-wide prediction and association mapping indicate that epistasis plays a significant role in heterosis of grain yield in wheat.

      Nature Genetics, Published online: 16 October 2017; doi:10.1038/ng.39742017-10-16
      DOI: 10.1038/ng.3974
       
  • Covariate selection for association screening in multiphenotype genetic
           studies
    • Covariate selection for association screening in multiphenotype genetic studies

      Nature Genetics, Published online: 16 October 2017; doi:10.1038/ng.3975

      Covariates for multiphenotype studies (CMS), a new approach for testing for associations from large-scale datasets, leverages genetic and environmental factors shared between correlated variables measured on the same samples. Applying CMS to real and simulated data demonstrates a large increase in power equivalent to that gained by doubling the sample size.

      Nature Genetics, Published online: 16 October 2017; doi:10.1038/ng.39752017-10-16
      DOI: 10.1038/ng.3975
       
  • Enhancing GTEx by bridging the gaps between genotype, gene expression, and
           disease
    • Enhancing GTEx by bridging the gaps between genotype, gene expression, and disease

      Nature Genetics, Published online: 11 October 2017; doi:10.1038/ng.3969

      Genetic variants have been associated with myriad molecular phenotypes that provide new insight into the range of mechanisms underlying genetic traits and diseases. Identifying any particular genetic variant's cascade of effects, from molecule to individual, requires assaying multiple layers of molecular complexity. We introduce the Enhancing GTEx (eGTEx) project that extends the GTEx project to combine gene expression with additional intermediate molecular measurements on the same tissues to provide a resource for studying how genetic differences cascade through molecular phenotypes to impact human health.

      Nature Genetics, Published online: 11 October 2017; doi:10.1038/ng.39692017-10-11
      DOI: 10.1038/ng.3969
       
  • Contribution of rare inherited and de novo variants in 2,871 congenital
           heart disease probands
    • Contribution of rare inherited and de novo variants in 2,871 congenital heart disease probands

      Nature Genetics, Published online: 9 October 2017; doi:10.1038/ng.3970

      Exome sequencing of 2,871 probands with congenital heart disease (CHD) provides new insights into the genetic architecture of these disorders. The results implicate new genes in CHD pathogenesis and highlight striking overlap between genes with damaging de novo mutations in individuals with CHD and autism.

      Nature Genetics, Published online: 9 October 2017; doi:10.1038/ng.39702017-10-09
      DOI: 10.1038/ng.3970
       
  • The draft genome of tropical fruit durian (Durio zibethinus)
    • The draft genome of tropical fruit durian (Durio zibethinus)

      Nature Genetics, Published online: 9 October 2017; doi:10.1038/ng.3972

      The assembly of the durian genome provides insights into the unique flavor profile of this tropical fruit. Transcriptome and metabolome analyses show that methionine γ-lyase is upregulated and that volatile sulfur compounds are produced during ripening.

      Nature Genetics, Published online: 9 October 2017; doi:10.1038/ng.39722017-10-09
      DOI: 10.1038/ng.3972
       
  • Patient-derived xenografts undergo mouse-specific tumor evolution
    • Patient-derived xenografts undergo mouse-specific tumor evolution

      Nature Genetics, Published online: 9 October 2017; doi:10.1038/ng.3967

      This large-scale analysis of copy number alterations (CNAs) in patient-derived xenografts (PDXs) across 24 cancer types shows that new CNAs accumulate quickly and that the specific CNAs acquired during passaging differ from those acquired during tumor evolution in patients, suggesting that PDX tumors are under distinct selection pressures from tumors in human hosts.

      Nature Genetics, Published online: 9 October 2017; doi:10.1038/ng.39672017-10-09
      DOI: 10.1038/ng.3967
       
  • Genome-wide association analysis identifies 30 new susceptibility loci for
           schizophrenia
    • Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia

      Nature Genetics, Published online: 9 October 2017; doi:10.1038/ng.3973

      A genome-wide association analysis using data from Chinese individuals combined with a transethnic meta-analysis of Psychiatry Genomics Consortium data identifies 30 new loci for schizophrenia. These analyses improve the fine-mapping of susceptibility loci and implicate multiple pathways in schizophrenia biology.

      Nature Genetics, Published online: 9 October 2017; doi:10.1038/ng.39732017-10-09
      DOI: 10.1038/ng.3973
       
  • Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like
           proteins at enhancers is dispensable for development and viability
    • Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability

      Nature Genetics, Published online: 2 October 2017; doi:10.1038/ng.3965

      Ali Shilatifard and colleagues generate Drosophila lines expressing catalytically deficient Trr, which normally deposits H3K4me1 at enhancers. Trr mutants undergo normal development and show minimal changes in gene expression.

      Nature Genetics, Published online: 2 October 2017; doi:10.1038/ng.39652017-10-02
      DOI: 10.1038/ng.3965
       
 
 
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