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Journal Cover Nature Genetics
  [SJR: 23.762]   [H-I: 469]   [513 followers]  Follow
    
   Full-text available via subscription Subscription journal
   ISSN (Print) 1061-4036 - ISSN (Online) 1546-1718
   Published by NPG Homepage  [142 journals]
  • 3′ UTR shortening represses tumor-suppressor genes in trans by
           disrupting ceRNA crosstalk
    • 3′ UTR shortening represses tumor-suppressor genes in trans by disrupting ceRNA crosstalk

      3′ UTR shortening represses tumor-suppressor genes in trans by disrupting ceRNA crosstalk, Published online: 21 May 2018; doi:10.1038/s41588-018-0118-8

      Shortening of mRNA 3′ UTRs is often observed in cancer. A combination of model-based analysis and experiments suggests that 3′ UTR shortening disrupts competing endogenous RNA crosstalk, thus influencing tumor-suppressor expression in trans.3′ UTR shortening represses tumor-suppressor genes in trans by disrupting ceRNA crosstalk, Published online: 2018-05-21; doi:10.1038/s41588-018-0118-82018-05-21
      DOI: 10.1038/s41588-018-0118-8
       
  • Multiplex assessment of protein variant abundance by massively parallel
           sequencing
    • Multiplex assessment of protein variant abundance by massively parallel sequencing

      Multiplex assessment of protein variant abundance by massively parallel sequencing, Published online: 21 May 2018; doi:10.1038/s41588-018-0122-z

      VAMP-seq is a scalable assay that measures the effects of missense variants on intracellular protein abundance. Applying VAMP-seq to thousands of PTEN and TPMT variants helps to classify them as pathogenic or benign.Multiplex assessment of protein variant abundance by massively parallel sequencing, Published online: 2018-05-21; doi:10.1038/s41588-018-0122-z2018-05-21
      DOI: 10.1038/s41588-018-0122-z
       
  • Genome-wide analyses identify 68 new loci associated with intraocular
           pressure and improve risk prediction for primary open-angle glaucoma
    • Genome-wide analyses identify 68 new loci associated with intraocular pressure and improve risk prediction for primary open-angle glaucoma

      Genome-wide analyses identify 68 new loci associated with intraocular pressure and improve risk prediction for primary open-angle glaucoma, Published online: 21 May 2018; doi:10.1038/s41588-018-0126-8

      A meta-analysis of 139,555 Europeans identifies 68 new genomic loci associated with intraocular pressure. Incorporating these new findings into genetic models improves risk prediction for primary open-angle glaucoma.Genome-wide analyses identify 68 new loci associated with intraocular pressure and improve risk prediction for primary open-angle glaucoma, Published online: 2018-05-21; doi:10.1038/s41588-018-0126-82018-05-21
      DOI: 10.1038/s41588-018-0126-8
       
  • Genetic identification of brain cell types underlying schizophrenia
    • Genetic identification of brain cell types underlying schizophrenia

      Genetic identification of brain cell types underlying schizophrenia, Published online: 21 May 2018; doi:10.1038/s41588-018-0129-5

      Integration of single-cell RNA sequencing with genome-wide association data implicates specific brain cell types in schizophrenia. Gene sets previously associated with schizophrenia implicate the same cell types, which include pyramidal cells and medium spiny neurons.Genetic identification of brain cell types underlying schizophrenia, Published online: 2018-05-21; doi:10.1038/s41588-018-0129-52018-05-21
      DOI: 10.1038/s41588-018-0129-5
       
  • Frequent transmission of the Mycobacterium tuberculosis Beijing lineage
           and positive selection for the EsxW Beijing variant in Vietnam
    • Frequent transmission of the Mycobacterium tuberculosis Beijing lineage and positive selection for the EsxW Beijing variant in Vietnam

      Frequent transmission of the Mycobacterium tuberculosis Beijing lineage and positive selection for the EsxW Beijing variant in Vietnam, Published online: 21 May 2018; doi:10.1038/s41588-018-0117-9

      Genomic analysis of Mycobacterium tuberculosis (Mtb) isolated from tuberculosis patients identifies the transmission dynamics of Mtb in Vietnam including frequent transmission of Beijing lineage and positive selection for EsxW Beijing variant.Frequent transmission of the Mycobacterium tuberculosis Beijing lineage and positive selection for the EsxW Beijing variant in Vietnam, Published online: 2018-05-21; doi:10.1038/s41588-018-0117-92018-05-21
      DOI: 10.1038/s41588-018-0117-9
       
  • A genome-wide cross-trait analysis from UK Biobank highlights the shared
           genetic architecture of asthma and allergic diseases
    • A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases

      A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases, Published online: 21 May 2018; doi:10.1038/s41588-018-0121-0

      Genome-wide cross-trait analysis shows a strong genetic correlation between asthma and allergic diseases. Shared susceptibility loci are enriched for genes involved in immune and inflammatory responses and genes expressed in epithelial tissues.A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases, Published online: 2018-05-21; doi:10.1038/s41588-018-0121-02018-05-21
      DOI: 10.1038/s41588-018-0121-0
       
  • Locus-specific control of the de novo DNA methylation pathway in
           Arabidopsis by the CLASSY family
    • Locus-specific control of the de novo DNA methylation pathway in Arabidopsis by the CLASSY family

      Locus-specific control of the de novo DNA methylation pathway in Arabidopsis by the CLASSY family, Published online: 07 May 2018; doi:10.1038/s41588-018-0115-y

      CLASSY chromatin remodeling factors (CLSY 1–4) are shown to regulate DNA methylation in Arabidopsis, both globally and in a locus-specific manner. CLSYs and RNA polymerase IV control the production of 24-nucleotide siRNAs, which guide DNA methylation.Locus-specific control of the de novo DNA methylation pathway in Arabidopsis by the CLASSY family, Published online: 2018-05-07; doi:10.1038/s41588-018-0115-y2018-05-07
      DOI: 10.1038/s41588-018-0115-y
       
  • Resequencing a core collection of upland cotton identifies genomic
           variation and loci influencing fiber quality and yield
    • Resequencing a core collection of upland cotton identifies genomic variation and loci influencing fiber quality and yield

      Resequencing a core collection of upland cotton identifies genomic variation and loci influencing fiber quality and yield, Published online: 07 May 2018; doi:10.1038/s41588-018-0119-7

      The authors resequence a core collection of upland cotton (Gossypium hirsutum) comprising 419 accessions. They analyze genomic variation and conduct a genome-wide association study for 13 fiber quality and yield traits in 12 different environments.Resequencing a core collection of upland cotton identifies genomic variation and loci influencing fiber quality and yield, Published online: 2018-05-07; doi:10.1038/s41588-018-0119-72018-05-07
      DOI: 10.1038/s41588-018-0119-7
       
 
 
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