Journal Cover Nature Cell Biology
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   ISSN (Print) 1465-7392 - ISSN (Online) 1476-4679
   Published by NPG Homepage  [143 journals]
  • Single-cell analysis identifies a CD33+ subset of human cord blood cells
           with high regenerative potential
    • Single-cell analysis identifies a CD33+ subset of human cord blood cells with high regenerative potential

      Single-cell analysis identifies a CD33+ subset of human cord blood cells with high regenerative potential, Published online: 25 May 2018; doi:10.1038/s41556-018-0104-5

      Knapp et al. analyse the heterogeneous molecular profiles and functions of CD49f human cord blood haematopoietic stem cells and report that a subset with CD33 expression has improved regenerative activity.Single-cell analysis identifies a CD33+ subset of human cord blood cells with high regenerative potential, Published online: 2018-05-25; doi:10.1038/s41556-018-0104-52018-05-25
      DOI: 10.1038/s41556-018-0104-5
       
  • Regulation of cell cycle progression by cell–cell and
           cell–matrix forces
    • Regulation of cell cycle progression by cell–cell and cell–matrix forces

      Regulation of cell cycle progression by cell–cell and cell–matrix forces, Published online: 25 May 2018; doi:10.1038/s41556-018-0107-2

      Monitoring growing epithelial cells through the cell cycle, Uroz et al. find that cell–cell tension and cell–matrix traction forces differ across the cell cycle and affect cell cycle duration, the G1–S transition and mitotic rounding.Regulation of cell cycle progression by cell–cell and cell–matrix forces, Published online: 2018-05-25; doi:10.1038/s41556-018-0107-22018-05-25
      DOI: 10.1038/s41556-018-0107-2
       
  • Tracing the temporal-spatial transcriptome landscapes of the human fetal
           digestive tract using single-cell RNA-sequencing
    • Tracing the temporal-spatial transcriptome landscapes of the human fetal digestive tract using single-cell RNA-sequencing

      Tracing the temporal-spatial transcriptome landscapes of the human fetal digestive tract using single-cell RNA-sequencing, Published online: 25 May 2018; doi:10.1038/s41556-018-0105-4

      Gao et al. provide a comprehensive single-cell transcriptomic resource of four organs from the human fetal gastrointestinal tract and adult large intestine.Tracing the temporal-spatial transcriptome landscapes of the human fetal digestive tract using single-cell RNA-sequencing, Published online: 2018-05-25; doi:10.1038/s41556-018-0105-42018-05-25
      DOI: 10.1038/s41556-018-0105-4
       
  • A confetti trail of tumour evolution
    • A confetti trail of tumour evolution

      A confetti trail of tumour evolution, Published online: 25 May 2018; doi:10.1038/s41556-018-0110-7

      Multiple clones of cancer cells co-exist within a tumour, and yet it is not clear when these subclones arise and how they contribute to tumour progression. A multicolour clonal tracing study now shows that benign skin tumours are mostly monoclonal while the more advanced lesions are composed of multiple intermixed subclones.A confetti trail of tumour evolution, Published online: 2018-05-25; doi:10.1038/s41556-018-0110-72018-05-25
      DOI: 10.1038/s41556-018-0110-7
       
  • Spectrin is a mechanoresponsive protein shaping fusogenic synapse
           architecture during myoblast fusion
    • Spectrin is a mechanoresponsive protein shaping fusogenic synapse architecture during myoblast fusion

      Spectrin is a mechanoresponsive protein shaping fusogenic synapse architecture during myoblast fusion, Published online: 25 May 2018; doi:10.1038/s41556-018-0106-3

      Duan et al. find that the membrane skeleton protein spectrin is required for myoblast fusion in Drosophila, accumulating in a mechanosensitive manner in the receiving partner during cell–cell fusion to modulate adhesion and protrusion events.Spectrin is a mechanoresponsive protein shaping fusogenic synapse architecture during myoblast fusion, Published online: 2018-05-25; doi:10.1038/s41556-018-0106-32018-05-25
      DOI: 10.1038/s41556-018-0106-3
       
  • Protein quality and miRNA slicing get into phase
    • Protein quality and miRNA slicing get into phase

      Protein quality and miRNA slicing get into phase, Published online: 25 May 2018; doi:10.1038/s41556-018-0113-4

      Phase separation can build assemblies and regulate biological function. Two articles link specific forms of protein and RNA degradation to phase separation. The polyubiquitin shuttle factor UBQLN2 localizes to stress granules where it may extract ubiquitinated proteins, and the miRISC complex functions through phase separation.Protein quality and miRNA slicing get into phase, Published online: 2018-05-25; doi:10.1038/s41556-018-0113-42018-05-25
      DOI: 10.1038/s41556-018-0113-4
       
  • Multicolour lineage tracing reveals clonal dynamics of squamous carcinoma
           evolution from initiation to metastasis
    • Multicolour lineage tracing reveals clonal dynamics of squamous carcinoma evolution from initiation to metastasis

      Multicolour lineage tracing reveals clonal dynamics of squamous carcinoma evolution from initiation to metastasis, Published online: 25 May 2018; doi:10.1038/s41556-018-0109-0

      Reeves et al. use a multistage skin carcinogenesis mouse model and multicoloured lineage tracing to analyse the different patterns of clonal evolution and behaviour seen in progressing and non-progressing papillomas.Multicolour lineage tracing reveals clonal dynamics of squamous carcinoma evolution from initiation to metastasis, Published online: 2018-05-25; doi:10.1038/s41556-018-0109-02018-05-25
      DOI: 10.1038/s41556-018-0109-0
       
  • Mammary lineage restriction in development
    • Mammary lineage restriction in development

      Mammary lineage restriction in development, Published online: 21 May 2018; doi:10.1038/s41556-018-0111-6

      The establishment of the two distinct lineages that form the branched epithelial ductal tree of the mammary gland is a complex and essential developmental process. Two independent studies now describe the switch from multipotency to unipotency as an embryonic process and outline mechanisms of early lineage restriction.Mammary lineage restriction in development, Published online: 2018-05-21; doi:10.1038/s41556-018-0111-62018-05-21
      DOI: 10.1038/s41556-018-0111-6
       
 
 
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