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MATHEMATICS (656 journals)                  1 2 3 4 | Last

Showing 1 - 200 of 538 Journals sorted alphabetically
Abakós     Open Access   (Followers: 3)
Abhandlungen aus dem Mathematischen Seminar der Universitat Hamburg     Hybrid Journal   (Followers: 3)
Academic Voices : A Multidisciplinary Journal     Open Access   (Followers: 2)
Accounting Perspectives     Full-text available via subscription   (Followers: 8)
ACM Transactions on Algorithms (TALG)     Hybrid Journal   (Followers: 16)
ACM Transactions on Computational Logic (TOCL)     Hybrid Journal   (Followers: 4)
ACM Transactions on Mathematical Software (TOMS)     Hybrid Journal   (Followers: 6)
ACS Applied Materials & Interfaces     Full-text available via subscription   (Followers: 22)
Acta Applicandae Mathematicae     Hybrid Journal   (Followers: 1)
Acta Mathematica     Hybrid Journal   (Followers: 11)
Acta Mathematica Hungarica     Hybrid Journal   (Followers: 2)
Acta Mathematica Scientia     Full-text available via subscription   (Followers: 5)
Acta Mathematica Sinica, English Series     Hybrid Journal   (Followers: 5)
Acta Mathematica Vietnamica     Hybrid Journal  
Acta Mathematicae Applicatae Sinica, English Series     Hybrid Journal  
Advanced Science Letters     Full-text available via subscription   (Followers: 7)
Advances in Applied Clifford Algebras     Hybrid Journal   (Followers: 3)
Advances in Calculus of Variations     Hybrid Journal   (Followers: 2)
Advances in Catalysis     Full-text available via subscription   (Followers: 5)
Advances in Complex Systems     Hybrid Journal   (Followers: 7)
Advances in Computational Mathematics     Hybrid Journal   (Followers: 15)
Advances in Decision Sciences     Open Access   (Followers: 5)
Advances in Difference Equations     Open Access   (Followers: 1)
Advances in Fixed Point Theory     Open Access   (Followers: 5)
Advances in Geosciences (ADGEO)     Open Access   (Followers: 10)
Advances in Linear Algebra & Matrix Theory     Open Access   (Followers: 2)
Advances in Materials Sciences     Open Access   (Followers: 16)
Advances in Mathematical Physics     Open Access   (Followers: 5)
Advances in Mathematics     Full-text available via subscription   (Followers: 10)
Advances in Numerical Analysis     Open Access   (Followers: 4)
Advances in Operations Research     Open Access   (Followers: 11)
Advances in Porous Media     Full-text available via subscription   (Followers: 4)
Advances in Pure and Applied Mathematics     Hybrid Journal   (Followers: 6)
Advances in Pure Mathematics     Open Access   (Followers: 4)
Advances in Science and Research (ASR)     Open Access   (Followers: 6)
Aequationes Mathematicae     Hybrid Journal   (Followers: 2)
African Journal of Educational Studies in Mathematics and Sciences     Full-text available via subscription   (Followers: 5)
African Journal of Mathematics and Computer Science Research     Open Access   (Followers: 4)
Afrika Matematika     Hybrid Journal   (Followers: 1)
Air, Soil & Water Research     Open Access   (Followers: 7)
AKSIOMA Journal of Mathematics Education     Open Access   (Followers: 1)
Al-Jabar : Jurnal Pendidikan Matematika     Open Access  
Algebra and Logic     Hybrid Journal   (Followers: 4)
Algebra Colloquium     Hybrid Journal   (Followers: 4)
Algebra Universalis     Hybrid Journal   (Followers: 2)
Algorithmic Operations Research     Full-text available via subscription   (Followers: 5)
Algorithms     Open Access   (Followers: 11)
Algorithms Research     Open Access   (Followers: 1)
American Journal of Biostatistics     Open Access   (Followers: 9)
American Journal of Computational and Applied Mathematics     Open Access   (Followers: 4)
American Journal of Mathematical Analysis     Open Access  
American Journal of Mathematics     Full-text available via subscription   (Followers: 7)
American Journal of Operations Research     Open Access   (Followers: 5)
American Mathematical Monthly     Full-text available via subscription   (Followers: 6)
An International Journal of Optimization and Control: Theories & Applications     Open Access   (Followers: 7)
Analele Universitatii Ovidius Constanta - Seria Matematica     Open Access   (Followers: 1)
Analysis     Hybrid Journal   (Followers: 2)
Analysis and Applications     Hybrid Journal   (Followers: 1)
Analysis and Mathematical Physics     Hybrid Journal   (Followers: 3)
Analysis Mathematica     Full-text available via subscription  
Annales Mathematicae Silesianae     Open Access  
Annales mathématiques du Québec     Hybrid Journal   (Followers: 4)
Annales UMCS, Mathematica     Open Access   (Followers: 1)
Annales Universitatis Paedagogicae Cracoviensis. Studia Mathematica     Open Access  
Annali di Matematica Pura ed Applicata     Hybrid Journal   (Followers: 1)
Annals of Combinatorics     Hybrid Journal   (Followers: 3)
Annals of Data Science     Hybrid Journal   (Followers: 9)
Annals of Discrete Mathematics     Full-text available via subscription   (Followers: 6)
Annals of Mathematics     Full-text available via subscription  
Annals of Mathematics and Artificial Intelligence     Hybrid Journal   (Followers: 6)
Annals of Pure and Applied Logic     Open Access   (Followers: 2)
Annals of the Alexandru Ioan Cuza University - Mathematics     Open Access  
Annals of the Institute of Statistical Mathematics     Hybrid Journal   (Followers: 1)
Annals of West University of Timisoara - Mathematics     Open Access  
Annuaire du Collège de France     Open Access   (Followers: 5)
Applicable Algebra in Engineering, Communication and Computing     Hybrid Journal   (Followers: 2)
Applications of Mathematics     Hybrid Journal   (Followers: 1)
Applied Categorical Structures     Hybrid Journal   (Followers: 2)
Applied Computational Intelligence and Soft Computing     Open Access   (Followers: 12)
Applied Mathematics     Open Access   (Followers: 3)
Applied Mathematics     Open Access   (Followers: 4)
Applied Mathematics & Optimization     Hybrid Journal   (Followers: 4)
Applied Mathematics - A Journal of Chinese Universities     Hybrid Journal  
Applied Mathematics Letters     Full-text available via subscription   (Followers: 1)
Applied Mathematics Research eXpress     Hybrid Journal   (Followers: 1)
Applied Network Science     Open Access  
Applied Numerical Mathematics     Hybrid Journal   (Followers: 5)
Applied Spatial Analysis and Policy     Hybrid Journal   (Followers: 4)
Arab Journal of Mathematical Sciences     Open Access   (Followers: 3)
Arabian Journal of Mathematics     Open Access   (Followers: 2)
Archive for Mathematical Logic     Hybrid Journal   (Followers: 1)
Archive of Applied Mechanics     Hybrid Journal   (Followers: 5)
Archive of Numerical Software     Open Access  
Archives of Computational Methods in Engineering     Hybrid Journal   (Followers: 4)
Arkiv för Matematik     Hybrid Journal   (Followers: 1)
Arnold Mathematical Journal     Hybrid Journal   (Followers: 1)
Artificial Satellites : The Journal of Space Research Centre of Polish Academy of Sciences     Open Access   (Followers: 19)
Asia-Pacific Journal of Operational Research     Hybrid Journal   (Followers: 3)
Asian Journal of Algebra     Open Access   (Followers: 1)
Asian Journal of Current Engineering & Maths     Open Access  
Asian-European Journal of Mathematics     Hybrid Journal   (Followers: 2)
Australian Mathematics Teacher, The     Full-text available via subscription   (Followers: 7)
Australian Primary Mathematics Classroom     Full-text available via subscription   (Followers: 2)
Australian Senior Mathematics Journal     Full-text available via subscription   (Followers: 1)
Automatic Documentation and Mathematical Linguistics     Hybrid Journal   (Followers: 5)
Axioms     Open Access  
Baltic International Yearbook of Cognition, Logic and Communication     Open Access  
Basin Research     Hybrid Journal   (Followers: 5)
BIBECHANA     Open Access  
BIT Numerical Mathematics     Hybrid Journal  
BoEM - Boletim online de Educação Matemática     Open Access  
Boletim Cearense de Educação e História da Matemática     Open Access  
Boletim de Educação Matemática     Open Access  
Boletín de la Sociedad Matemática Mexicana     Hybrid Journal  
Bollettino dell'Unione Matematica Italiana     Full-text available via subscription   (Followers: 1)
British Journal of Mathematical and Statistical Psychology     Full-text available via subscription   (Followers: 20)
Bruno Pini Mathematical Analysis Seminar     Open Access  
Buletinul Academiei de Stiinte a Republicii Moldova. Matematica     Open Access   (Followers: 7)
Bulletin des Sciences Mathamatiques     Full-text available via subscription   (Followers: 4)
Bulletin of Dnipropetrovsk University. Series : Communications in Mathematical Modeling and Differential Equations Theory     Open Access   (Followers: 1)
Bulletin of Mathematical Sciences     Open Access   (Followers: 1)
Bulletin of the Brazilian Mathematical Society, New Series     Hybrid Journal  
Bulletin of the London Mathematical Society     Hybrid Journal   (Followers: 3)
Bulletin of the Malaysian Mathematical Sciences Society     Hybrid Journal  
Calculus of Variations and Partial Differential Equations     Hybrid Journal  
Canadian Journal of Science, Mathematics and Technology Education     Hybrid Journal   (Followers: 18)
Carpathian Mathematical Publications     Open Access   (Followers: 1)
Catalysis in Industry     Hybrid Journal   (Followers: 1)
CEAS Space Journal     Hybrid Journal  
CHANCE     Hybrid Journal   (Followers: 5)
Chaos, Solitons & Fractals     Hybrid Journal   (Followers: 3)
ChemSusChem     Hybrid Journal   (Followers: 7)
Chinese Annals of Mathematics, Series B     Hybrid Journal  
Chinese Journal of Catalysis     Full-text available via subscription   (Followers: 2)
Chinese Journal of Mathematics     Open Access  
Clean Air Journal     Full-text available via subscription   (Followers: 2)
Cogent Mathematics     Open Access   (Followers: 2)
Cognitive Computation     Hybrid Journal   (Followers: 4)
Collectanea Mathematica     Hybrid Journal  
College Mathematics Journal     Full-text available via subscription   (Followers: 3)
COMBINATORICA     Hybrid Journal  
Combustion Theory and Modelling     Hybrid Journal   (Followers: 13)
Commentarii Mathematici Helvetici     Hybrid Journal   (Followers: 1)
Communications in Contemporary Mathematics     Hybrid Journal  
Communications in Mathematical Physics     Hybrid Journal   (Followers: 1)
Communications On Pure & Applied Mathematics     Hybrid Journal   (Followers: 3)
Complex Analysis and its Synergies     Open Access   (Followers: 2)
Complex Variables and Elliptic Equations: An International Journal     Hybrid Journal  
Complexus     Full-text available via subscription  
Composite Materials Series     Full-text available via subscription   (Followers: 9)
Comptes Rendus Mathematique     Full-text available via subscription   (Followers: 1)
Computational and Applied Mathematics     Hybrid Journal   (Followers: 2)
Computational and Mathematical Methods in Medicine     Open Access   (Followers: 2)
Computational and Mathematical Organization Theory     Hybrid Journal   (Followers: 2)
Computational Complexity     Hybrid Journal   (Followers: 4)
Computational Mathematics and Modeling     Hybrid Journal   (Followers: 8)
Computational Mechanics     Hybrid Journal   (Followers: 4)
Computational Methods and Function Theory     Hybrid Journal  
Computational Optimization and Applications     Hybrid Journal   (Followers: 7)
Computers & Mathematics with Applications     Full-text available via subscription   (Followers: 5)
Concrete Operators     Open Access   (Followers: 4)
Confluentes Mathematici     Hybrid Journal  
COSMOS     Hybrid Journal  
Cryptography and Communications     Hybrid Journal   (Followers: 14)
Cuadernos de Investigación y Formación en Educación Matemática     Open Access  
Cubo. A Mathematical Journal     Open Access  
Czechoslovak Mathematical Journal     Hybrid Journal   (Followers: 1)
Demographic Research     Open Access   (Followers: 11)
Demonstratio Mathematica     Open Access  
Dependence Modeling     Open Access  
Design Journal : An International Journal for All Aspects of Design     Hybrid Journal   (Followers: 28)
Developments in Clay Science     Full-text available via subscription   (Followers: 1)
Developments in Mineral Processing     Full-text available via subscription   (Followers: 3)
Dhaka University Journal of Science     Open Access  
Differential Equations and Dynamical Systems     Hybrid Journal   (Followers: 2)
Discrete Mathematics     Hybrid Journal   (Followers: 8)
Discrete Mathematics & Theoretical Computer Science     Open Access  
Discrete Mathematics, Algorithms and Applications     Hybrid Journal   (Followers: 2)
Discussiones Mathematicae Graph Theory     Open Access   (Followers: 1)
Dnipropetrovsk University Mathematics Bulletin     Open Access  
Doklady Mathematics     Hybrid Journal  
Duke Mathematical Journal     Full-text available via subscription   (Followers: 1)
Edited Series on Advances in Nonlinear Science and Complexity     Full-text available via subscription  
Electronic Journal of Graph Theory and Applications     Open Access   (Followers: 2)
Electronic Notes in Discrete Mathematics     Full-text available via subscription   (Followers: 2)
Elemente der Mathematik     Full-text available via subscription   (Followers: 3)
Energy for Sustainable Development     Hybrid Journal   (Followers: 9)
Enseñanza de las Ciencias : Revista de Investigación y Experiencias Didácticas     Open Access  
Ensino da Matemática em Debate     Open Access  
Entropy     Open Access   (Followers: 5)
ESAIM: Control Optimisation and Calculus of Variations     Full-text available via subscription   (Followers: 1)
European Journal of Combinatorics     Full-text available via subscription   (Followers: 5)
European Journal of Mathematics     Hybrid Journal   (Followers: 1)
European Scientific Journal     Open Access   (Followers: 2)
Experimental Mathematics     Hybrid Journal   (Followers: 4)
Expositiones Mathematicae     Hybrid Journal   (Followers: 2)
Facta Universitatis, Series : Mathematics and Informatics     Open Access  
Fasciculi Mathematici     Open Access  
Finite Fields and Their Applications     Full-text available via subscription   (Followers: 4)
Fixed Point Theory and Applications     Open Access   (Followers: 1)

        1 2 3 4 | Last

Journal Cover Computational and Mathematical Methods in Medicine
  [SJR: 0.415]   [H-I: 22]   [2 followers]  Follow
  This is an Open Access Journal Open Access journal
   ISSN (Print) 1748-670X - ISSN (Online) 1748-6718
   Published by Hindawi Homepage  [298 journals]
  • Modeling Impact of Temperature and Human Movement on the Persistence of
           Dengue Disease

    • Abstract: Dengue is a vector-borne infectious disease endemic in many parts of the world. The disease is spreading in new places due to human movement into the dengue disease supporting areas. Temperature is the major climatic factor which affects the biological processes of the mosquitoes and their interaction with the viruses. In the present work, we propose a multipatch model to assess the impact of temperature and human movement in the transmission dynamics of dengue disease. The work consists of system of ordinary differential equations that describe the transmission dynamics of dengue disease between humans and mosquitoes. Human population is divided into four classes: susceptible, exposed, infectious, and recovered. Mosquito population is divided into three classes: susceptible, exposed, and infectious. Basic reproduction number of the model is obtained using Next-Generation Matrix method. The qualitative analysis of the model is made in terms of the basic reproduction number. Parameters used in the model are considered temperature dependent. Dynamics of vector and host populations are investigated with different human movement rates and different temperature levels. Numerical results show that proper management of human movement between patches helps reducing the burden of dengue disease. It is also seen that the temperature affects the transmission dynamics of the disease significantly.
      PubDate: Tue, 19 Sep 2017 09:26:28 +000
  • Association of Stressful Life Events with Psychological Problems: A
           Large-Scale Community-Based Study Using Grouped Outcomes Latent Factor
           Regression with Latent Predictors

    • Abstract: Objective. The current study is aimed at investigating the association between stressful life events and psychological problems in a large sample of Iranian adults. Method. In a cross-sectional large-scale community-based study, 4763 Iranian adults, living in Isfahan, Iran, were investigated. Grouped outcomes latent factor regression on latent predictors was used for modeling the association of psychological problems (depression, anxiety, and psychological distress), measured by Hospital Anxiety and Depression Scale (HADS) and General Health Questionnaire (GHQ-12), as the grouped outcomes, and stressful life events, measured by a self-administered stressful life events (SLEs) questionnaire, as the latent predictors. Results. The results showed that the personal stressors domain has significant positive association with psychological distress (), anxiety (), depression (), and their collective profile score (), with greater associations in females () than in males () (all ). In addition, in the adjusted models, the regression coefficients for the association of social stressors domain and psychological problems profile score were 0.37, 0.35, and 0.46 in total sample, males, and females, respectively (). Conclusion. Results of our study indicated that different stressors, particularly those socioeconomic related, have an effective impact on psychological problems. It is important to consider the social and cultural background of a population for managing the stressors as an effective approach for preventing and reducing the destructive burden of psychological problems.
      PubDate: Tue, 19 Sep 2017 00:00:00 +000
  • Stochastic Models of Emerging Infectious Disease Transmission on Adaptive
           Random Networks

    • Abstract: We presented adaptive random network models to describe human behavioral change during epidemics and performed stochastic simulations of SIR (susceptible-infectious-recovered) epidemic models on adaptive random networks. The interplay between infectious disease dynamics and network adaptation dynamics was investigated in regard to the disease transmission and the cumulative number of infection cases. We found that the cumulative case was reduced and associated with an increasing network adaptation probability but was increased with an increasing disease transmission probability. It was found that the topological changes of the adaptive random networks were able to reduce the cumulative number of infections and also to delay the epidemic peak. Our results also suggest the existence of a critical value for the ratio of disease transmission and adaptation probabilities below which the epidemic cannot occur.
      PubDate: Sun, 17 Sep 2017 00:00:00 +000
  • Biomarker MicroRNAs for Diagnosis of Oral Squamous Cell Carcinoma
           Identified Based on Gene Expression Data and MicroRNA-mRNA Network

    • Abstract: Oral squamous cell carcinoma is one of the most malignant tumors with high mortality rate worldwide. Biomarker discovery is critical for early diagnosis and precision treatment of this disease. MicroRNAs are small noncoding RNA molecules which often regulate essential biological processes and are good candidates for biomarkers. By integrative analysis of both the cancer-associated gene expression data and microRNA-mRNA network, miR-148b-3p, miR-629-3p, miR-27a-3p, and miR-142-3p were screened as novel diagnostic biomarkers for oral squamous cell carcinoma based on their unique regulatory abilities in the network structure of the conditional microRNA-mRNA network and their important functions. These findings were confirmed by literature verification and functional enrichment analysis. Future experimental validation is expected for the further investigation of their molecular mechanisms.
      PubDate: Sun, 17 Sep 2017 00:00:00 +000
  • Modelling Risk to US Military Populations from Stopping Blanket Mandatory
           Polio Vaccination

    • Abstract: Objectives. Transmission of polio poses a threat to military forces when deploying to regions where such viruses are endemic. US-born soldiers generally enter service with immunity resulting from childhood immunization against polio; moreover, new recruits are routinely vaccinated with inactivated poliovirus vaccine (IPV), supplemented based upon deployment circumstances. Given residual protection from childhood vaccination, risk-based vaccination may sufficiently protect troops from polio transmission. Methods. This analysis employed a mathematical system for polio transmission within military populations interacting with locals in a polio-endemic region to evaluate changes in vaccination policy. Results. Removal of blanket immunization had no effect on simulated polio incidence among deployed military populations when risk-based immunization was employed; however, when these individuals reintegrated with their base populations, risk of transmission to nondeployed personnel increased by 19%. In the absence of both blanket- and risk-based immunization, transmission to nondeployed populations increased by 25%. The overall number of new infections among nondeployed populations was negligible for both scenarios due to high childhood immunization rates, partial protection against transmission conferred by IPV, and low global disease incidence levels. Conclusion. Risk-based immunization driven by deployment to polio-endemic regions is sufficient to prevent transmission among both deployed and nondeployed US military populations.
      PubDate: Thu, 14 Sep 2017 00:00:00 +000
  • Assessment of Differential Item Functioning in Health-Related Outcomes: A
           Simulation and Empirical Analysis with Hierarchical Polytomous Data

    • Abstract: Background. The purpose of this study was to evaluate the effectiveness of two methods of detecting differential item functioning (DIF) in the presence of multilevel data and polytomously scored items. The assessment of DIF with multilevel data (e.g., patients nested within hospitals, hospitals nested within districts) from large-scale assessment programs has received considerable attention but very few studies evaluated the effect of hierarchical structure of data on DIF detection for polytomously scored items. Methods. The ordinal logistic regression (OLR) and hierarchical ordinal logistic regression (HOLR) were utilized to assess DIF in simulated and real multilevel polytomous data. Six factors (DIF magnitude, grouping variable, intraclass correlation coefficient, number of clusters, number of participants per cluster, and item discrimination parameter) with a fully crossed design were considered in the simulation study. Furthermore, data of Pediatric Quality of Life Inventory™ (PedsQL™) 4.0 collected from 576 healthy school children were analyzed. Results. Overall, results indicate that both methods performed equivalently in terms of controlling Type I error and detection power rates. Conclusions. The current study showed negligible difference between OLR and HOLR in detecting DIF with polytomously scored items in a hierarchical structure. Implications and considerations while analyzing real data were also discussed.
      PubDate: Tue, 12 Sep 2017 10:17:54 +000
  • Modeling and Control for HIV/AIDS Transmission in China Based on Data from
           2004 to 2016

    • Abstract: HIV is one of the major life-threatening viruses that are spreading in the People’s Republic of China (China for short). A susceptible-exposed in the latent stage-infectious (SEI) model is established to sketch the evolution of epidemic. The basic reproduction number is defined. By constructing Lyapunov function, globally asymptotical stabilities of the disease-free and endemic equilibria are given. Then, optimal control theory is applied in HIV/AIDS epidemic. Precaution, screening, and treatment of control variables are introduced and a new model with control is established. Through the HIV/AIDS data in China, all parameters involved in SEI model are analyzed and parts of them are estimated. Further, by control model, optimal strategy is obtained. Results show that the precaution and treatment are the major contributors to preventing and controlling HIV/AIDS epidemic.
      PubDate: Tue, 12 Sep 2017 00:00:00 +000
  • Anisotropy Influences on the Drug Delivery Mechanisms by Means of Joint
           Invariant Functions

    • Abstract: In the frame of Higuchi’s type functionality, this paper presents the anisotropy influences on the drug delivery mechanisms through the joint invariant functions to the simultaneous actions of the two SL(2R) isomorphic groups. Then, a new equation for drug delivery mechanism, independent of the type of polymer matrix and/or drug, is proposed.
      PubDate: Sun, 10 Sep 2017 06:54:03 +000
  • The Applications of Finite Element Analysis in Proximal Humeral Fractures

    • Abstract: Proximal humeral fractures are common and most challenging, due to the complexity of the glenohumeral joint, especially in the geriatric population with impacted fractures, that the development of implants continues because currently the problems with their fixation are not solved. Pre-, intra-, and postoperative assessments are crucial in management of those patients. Finite element analysis, as one of the valuable tools, has been implemented as an effective and noninvasive method to analyze proximal humeral fractures, providing solid evidence for management of troublesome patients. However, no review article about the applications and effects of finite element analysis in assessing proximal humeral fractures has been reported yet. This review article summarized the applications, contribution, and clinical significance of finite element analysis in assessing proximal humeral fractures. Furthermore, the limitations of finite element analysis, the difficulties of more realistic simulation, and the validation and also the creation of validated FE models were discussed. We concluded that although some advancements in proximal humeral fractures researches have been made by using finite element analysis, utility of this powerful tool for routine clinical management and adequate simulation requires more state-of-the-art studies to provide evidence and bases.
      PubDate: Sun, 10 Sep 2017 00:00:00 +000
  • Modelling and Optimal Control of Typhoid Fever Disease with Cost-Effective

    • Abstract: We propose and analyze a compartmental nonlinear deterministic mathematical model for the typhoid fever outbreak and optimal control strategies in a community with varying population. The model is studied qualitatively using stability theory of differential equations and the basic reproductive number that represents the epidemic indicator is obtained from the largest eigenvalue of the next-generation matrix. Both local and global asymptotic stability conditions for disease-free and endemic equilibria are determined. The model exhibits a forward transcritical bifurcation and the sensitivity analysis is performed. The optimal control problem is designed by applying Pontryagin maximum principle with three control strategies, namely, the prevention strategy through sanitation, proper hygiene, and vaccination; the treatment strategy through application of appropriate medicine; and the screening of the carriers. The cost functional accounts for the cost involved in prevention, screening, and treatment together with the total number of the infected persons averted. Numerical results for the typhoid outbreak dynamics and its optimal control revealed that a combination of prevention and treatment is the best cost-effective strategy to eradicate the disease.
      PubDate: Sun, 10 Sep 2017 00:00:00 +000
  • Preventing Neurodegenerative Memory Loss in Hopfield Neuronal Networks
           Using Cerebral Organoids or External Microelectronics

    • Abstract: Developing technologies have made significant progress towards linking the brain with brain-machine interfaces (BMIs) which have the potential to aid damaged brains to perform their original motor and cognitive functions. We consider the viability of such devices for mitigating the deleterious effects of memory loss that is induced by neurodegenerative diseases and/or traumatic brain injury (TBI). Our computational study considers the widely used Hopfield network, an autoassociative memory model in which neurons converge to a stable state pattern after receiving an input resembling the given memory. In this study, we connect an auxiliary network of neurons, which models the BMI device, to the original Hopfield network and train it to converge to its own auxiliary memory patterns. Injuries to the original Hopfield memory network, induced through neurodegeneration, for instance, can then be analyzed with the goal of evaluating the ability of the BMI to aid in memory retrieval tasks. Dense connectivity between the auxiliary and Hopfield networks is shown to promote robustness of memory retrieval tasks for both optimal and nonoptimal memory sets. Our computations estimate damage levels and parameter ranges for which full or partial memory recovery is achievable, providing a starting point for novel therapeutic strategies.
      PubDate: Tue, 05 Sep 2017 00:00:00 +000
  • Hamiltonian Analysis of Subcritical Stochastic Epidemic Dynamics

    • Abstract: We extend a technique of approximation of the long-term behavior of a supercritical stochastic epidemic model, using the WKB approximation and a Hamiltonian phase space, to the subcritical case. The limiting behavior of the model and approximation are qualitatively different in the subcritical case, requiring a novel analysis of the limiting behavior of the Hamiltonian system away from its deterministic subsystem. This yields a novel, general technique of approximation of the quasistationary distribution of stochastic epidemic and birth-death models and may lead to techniques for analysis of these models beyond the quasistationary distribution. For a classic SIS model, the approximation found for the quasistationary distribution is very similar to published approximations but not identical. For a birth-death process without depletion of susceptibles, the approximation is exact. Dynamics on the phase plane similar to those predicted by the Hamiltonian analysis are demonstrated in cross-sectional data from trachoma treatment trials in Ethiopia, in which declining prevalences are consistent with subcritical epidemic dynamics.
      PubDate: Mon, 28 Aug 2017 00:00:00 +000
  • Sensitivity Analysis of the Integral Quality Monitoring System® Using
           Monte Carlo Simulation

    • Abstract: The Integral Quality Monitoring (IQM) System is a real-time beam output verifying system that validates the integrity and accuracy of patient treatment plan (TP) data during radiation treatment. The purpose of this study was to evaluate the sensitivity of the IQM to errors in segment using EGSnrc/BEAMnrc Monte Carlo (MC) codes. Sensitivity analysis (SA) techniques were applied to study the significance of small alterations of field sizes (segments) on the IQM signal response. One hundred and eighty multileaf segments were analyzed with methods that include scatter plots (SP), brute force, variance-based (VAR), and standard regression coefficient SA. The segments were altered randomly within ±1, ±2, and ±3 mm leaf steps for 10 MV photon beams. SP analysis gradient and VAR maximum index are 1.045 and 0.556 for the smallest segment while the largest segment has the value of 0.018 and 0.504, respectively. The brute force and standard regression displayed maximum sensitivity indices around the unaltered segments. These tests conclusively indicated that the IQM was more sensitive to alterations of small segments compared to larger segments. This is important since small segment variation will cause a higher dose output variation that should be picked up during online beam monitoring.
      PubDate: Sun, 27 Aug 2017 08:58:25 +000
  • Mechanistic Model for Cancer Growth and Response to Chemotherapy

    • Abstract: Cancer treatment has developed over the years; however not all patients respond to this treatment, and therefore further research is needed. In this paper, we employ mathematical modeling to understand the behavior of cancer and its interaction with therapy. We study a drug delivery and drug-cell interaction model along with cell proliferation. Due to the fact that cancer cells grow when there are enough nutrients and oxygen, proliferation can be a barrier against a response to therapy. To understand the effect of this factor, we perform numerical simulations of the model for different values of the parameters with a continuous delivery of the drug. The numerical results showed that cancer dies after short apoptotic cycles if the cancer is highly vascularized or if the penetration of the drug is high. This suggests promoting angiogenesis or perfusion of the drug. This result is similar to the situation where proliferation is not considered since the constant release of drug overcomes the growth of the cells and thus the effect of proliferation can be neglected.
      PubDate: Sun, 27 Aug 2017 07:52:09 +000
  • Dendritic Immunotherapy Improvement for an Optimal Control Murine Model

    • Abstract: Therapeutic protocols in immunotherapy are usually proposed following the intuition and experience of the therapist. In order to deduce such protocols mathematical modeling, optimal control and simulations are used instead of the therapist’s experience. Clinical efficacy of dendritic cell (DC) vaccines to cancer treatment is still unclear, since dendritic cells face several obstacles in the host environment, such as immunosuppression and poor transference to the lymph nodes reducing the vaccine effect. In view of that, we have created a mathematical murine model to measure the effects of dendritic cell injections admitting such obstacles. In addition, the model considers a therapy given by bolus injections of small duration as opposed to a continual dose. Doses timing defines the therapeutic protocols, which in turn are improved to minimize the tumor mass by an optimal control algorithm. We intend to supplement therapist’s experience and intuition in the protocol’s implementation. Experimental results made on mice infected with melanoma with and without therapy agree with the model. It is shown that the dendritic cells’ percentage that manages to reach the lymph nodes has a crucial impact on the therapy outcome. This suggests that efforts in finding better methods to deliver DC vaccines should be pursued.
      PubDate: Sun, 20 Aug 2017 00:00:00 +000
  • Pathway Interaction Network Analysis Identifies Dysregulated Pathways in
           Human Monocytes Infected by Listeria monocytogenes

    • Abstract: In our study, we aimed to extract dysregulated pathways in human monocytes infected by Listeria monocytogenes (LM) based on pathway interaction network (PIN) which presented the functional dependency between pathways. After genes were aligned to the pathways, principal component analysis (PCA) was used to calculate the pathway activity for each pathway, followed by detecting seed pathway. A PIN was constructed based on gene expression profile, protein-protein interactions (PPIs), and cellular pathways. Identifying dysregulated pathways from the PIN was performed relying on seed pathway and classification accuracy. To evaluate whether the PIN method was feasible or not, we compared the introduced method with standard network centrality measures. The pathway of RNA polymerase II pretranscription events was selected as the seed pathway. Taking this seed pathway as start, one pathway set (9 dysregulated pathways) with AUC score of 1.00 was identified. Among the 5 hub pathways obtained using standard network centrality measures, 4 pathways were the common ones between the two methods. RNA polymerase II transcription and DNA replication owned a higher number of pathway genes and DEGs. These dysregulated pathways work together to influence the progression of LM infection, and they will be available as biomarkers to diagnose LM infection.
      PubDate: Wed, 16 Aug 2017 09:10:06 +000
  • Products of Compartmental Models in Epidemiology

    • Abstract: We show that many structured epidemic models may be described using a straightforward product structure in this paper. Such products, derived from products of directed graphs, may represent useful refinements including geographic and demographic structure, age structure, gender, risk groups, or immunity status. Extension to multistrain dynamics, that is, pathogen heterogeneity, is also shown to be feasible in this framework. Systematic use of such products may aid in model development and exploration, can yield insight, and could form the basis of a systematic approach to numerical structural sensitivity analysis.
      PubDate: Wed, 16 Aug 2017 00:00:00 +000
  • A Novel Dynamic Model Describing the Spread of the MERS-CoV and the
           Expression of Dipeptidyl Peptidase 4

    • Abstract: The Middle East respiratory syndrome (MERS) coronavirus, a newly identified pathogen, causes severe pneumonia in humans. MERS is caused by a coronavirus known as MERS-CoV, which attacks the respiratory system. The recently defined receptor for MERS-CoV, dipeptidyl peptidase 4 (DPP4), is generally expressed in endothelial and epithelial cells and has been shown to be present on cultured human nonciliated bronchiolar epithelium cells. In this paper, a class of novel four-dimensional dynamic model describing the infection of MERS-CoV is given, and then global stability of the equilibria of the model is discussed. Our results show that the spread of MERS-CoV can also be controlled by decreasing the expression rate of DPP4.
      PubDate: Tue, 15 Aug 2017 00:00:00 +000
  • Computational and Mathematical Methods to Estimate the Basic Reproduction
           Number and Final Size for Single-Stage and Multistage Progression Disease
           Models for Zika with Preventative Measures

    • Abstract: We present new mathematical models that include the impact of using selected preventative measures such as insecticide treated nets (ITN) in controlling or ameliorating the spread of the Zika virus. For these models, we derive the basic reproduction number and sharp estimates for the final size relation. We first present a single-stage model which is later extended to a new multistage model for Zika that incorporates more realistic incubation stages for both the humans and vectors. For each of these models, we derive a basic reproduction number and a final size relation estimate. We observe that the basic reproduction number for the multistage model converges to expected values for a standard Zika epidemic model with fixed incubation periods in both hosts and vectors. Finally, we also perform several computational experiments to validate the theoretical results obtained in this work and study the influence of various parameters on the models.
      PubDate: Tue, 15 Aug 2017 00:00:00 +000
  • Effect of Rainfall for the Dynamical Transmission Model of the Dengue
           Disease in Thailand

    • Abstract: The SEIR (Susceptible-Exposed-Infected-Recovered) model is used to describe the transmission of dengue virus. The main contribution is determining the role of the rainfall in Thailand in the model. The transmission of dengue disease is assumed to depend on the nature of the rainfall in Thailand. We analyze the dynamic transmission of dengue disease. The stability of the solution of the model is analyzed. It is investigated by using the Routh-Hurwitz criteria. We find two equilibrium states: a disease-free state and an endemic equilibrium state. The basic reproductive number () is obtained, which indicates the stability of each equilibrium state. Numerical results taking into account the rainfall are obtained and they are seen to correspond to the analytical results.
      PubDate: Tue, 08 Aug 2017 08:16:12 +000
  • Segmentation of Left and Right Ventricles in Cardiac MRI Using Active

    • Abstract: Segmentation of left and right ventricles plays a crucial role in quantitatively analyzing the global and regional information in the cardiac magnetic resonance imaging (MRI). In MRI, the intensity inhomogeneity and weak or blurred object boundaries are the problems, which makes it difficult for the intensity-based segmentation methods to properly delineate the regions of interests (ROI). In this paper, a hybrid signed pressure force function (SPF) is proposed, which yields both local and global image fitted differences in an additive fashion. A characteristic term is also introduced in the SPF function to restrict the contour within the ROI. The overlapping dice index and Hausdorff-Distance metrics have been used over cardiac datasets for quantitative validation. Using 2009 LV MICCAI validation dataset, the proposed method yields DSC values of 0.95 and 0.97 for endocardial and epicardial contours, respectively. Using 2012 RV MICCAI dataset, for the endocardial region, the proposed method yields DSC values of 0.97 and 0.90 and HD values of 8.51 and 7.67 for ED and ES, respectively. For the epicardial region, it yields DSC values of 0.92 and 0.91 and HD values of 6.47 and 9.34 for ED and ES, respectively. Results show its robustness in the segmentation application of the cardiac MRI.
      PubDate: Tue, 08 Aug 2017 06:26:31 +000
  • An Update on Statistical Boosting in Biomedicine

    • Abstract: Statistical boosting algorithms have triggered a lot of research during the last decade. They combine a powerful machine learning approach with classical statistical modelling, offering various practical advantages like automated variable selection and implicit regularization of effect estimates. They are extremely flexible, as the underlying base-learners (regression functions defining the type of effect for the explanatory variables) can be combined with any kind of loss function (target function to be optimized, defining the type of regression setting). In this review article, we highlight the most recent methodological developments on statistical boosting regarding variable selection, functional regression, and advanced time-to-event modelling. Additionally, we provide a short overview on relevant applications of statistical boosting in biomedicine.
      PubDate: Wed, 02 Aug 2017 07:57:33 +000
  • A Multicriteria Approach to Find Predictive and Sparse Models with Stable
           Feature Selection for High-Dimensional Data

    • Abstract: Finding a good predictive model for a high-dimensional data set can be challenging. For genetic data, it is not only important to find a model with high predictive accuracy, but it is also important that this model uses only few features and that the selection of these features is stable. This is because, in bioinformatics, the models are used not only for prediction but also for drawing biological conclusions which makes the interpretability and reliability of the model crucial. We suggest using three target criteria when fitting a predictive model to a high-dimensional data set: the classification accuracy, the stability of the feature selection, and the number of chosen features. As it is unclear which measure is best for evaluating the stability, we first compare a variety of stability measures. We conclude that the Pearson correlation has the best theoretical and empirical properties. Also, we find that for the stability assessment behaviour it is most important that a measure contains a correction for chance or large numbers of chosen features. Then, we analyse Pareto fronts and conclude that it is possible to find models with a stable selection of few features without losing much predictive accuracy.
      PubDate: Tue, 01 Aug 2017 08:01:06 +000
  • Several Indicators of Critical Transitions for Complex Diseases Based on
           Stochastic Analysis

    • Abstract: Many complex diseases (chronic disease onset, development and differentiation, self-assembly, etc.) are reminiscent of phase transitions in a dynamical system: quantitative changes accumulate largely unnoticed until a critical threshold is reached, which causes abrupt qualitative changes of the system. Understanding such nonlinear behaviors is critical to dissect the multiple genetic/environmental factors that together shape the genetic and physiological landscape underlying basic biological functions and to identify the key driving molecules. Based on stochastic differential equation (SDE) model, we theoretically derive three statistical indicators, that is, coefficient of variation (CV), transformed Pearson’s correlation coefficient (TPC), and transformed probability distribution (TPD), to identify critical transitions and detect the early-warning signals of the phase transition in complex diseases. To verify the effectiveness of these early-warning indexes, we use high-throughput data for three complex diseases, including influenza caused by either H3N2 or H1N1 and acute lung injury, to extract the dynamical network biomarkers (DNBs) responsible for catastrophic transition into the disease state from predisease state. The numerical results indicate that the derived indicators provide a data-based quantitative analysis for early-warning signals for critical transitions in complex diseases or other dynamical systems.
      PubDate: Tue, 01 Aug 2017 07:04:13 +000
  • Probing for Sparse and Fast Variable Selection with Model-Based Boosting

    • Abstract: We present a new variable selection method based on model-based gradient boosting and randomly permuted variables. Model-based boosting is a tool to fit a statistical model while performing variable selection at the same time. A drawback of the fitting lies in the need of multiple model fits on slightly altered data (e.g., cross-validation or bootstrap) to find the optimal number of boosting iterations and prevent overfitting. In our proposed approach, we augment the data set with randomly permuted versions of the true variables, so-called shadow variables, and stop the stepwise fitting as soon as such a variable would be added to the model. This allows variable selection in a single fit of the model without requiring further parameter tuning. We show that our probing approach can compete with state-of-the-art selection methods like stability selection in a high-dimensional classification benchmark and apply it on three gene expression data sets.
      PubDate: Mon, 31 Jul 2017 06:43:12 +000
  • Integration of Multiple Genomic Data Sources in a Bayesian Cox Model for
           Variable Selection and Prediction

    • Abstract: Bayesian variable selection becomes more and more important in statistical analyses, in particular when performing variable selection in high dimensions. For survival time models and in the presence of genomic data, the state of the art is still quite unexploited. One of the more recent approaches suggests a Bayesian semiparametric proportional hazards model for right censored time-to-event data. We extend this model to directly include variable selection, based on a stochastic search procedure within a Markov chain Monte Carlo sampler for inference. This equips us with an intuitive and flexible approach and provides a way for integrating additional data sources and further extensions. We make use of the possibility of implementing parallel tempering to help improve the mixing of the Markov chains. In our examples, we use this Bayesian approach to integrate copy number variation data into a gene-expression-based survival prediction model. This is achieved by formulating an informed prior based on copy number variation. We perform a simulation study to investigate the model’s behavior and prediction performance in different situations before applying it to a dataset of glioblastoma patients and evaluating the biological relevance of the findings.
      PubDate: Sun, 30 Jul 2017 09:24:19 +000
  • Convolutional Neural Network for the Detection of End-Diastole and
           End-Systole Frames in Free-Breathing Cardiac Magnetic Resonance Imaging

    • Abstract: Free-breathing cardiac magnetic resonance (CMR) imaging has short examination time with high reproducibility. Detection of the end-diastole and the end-systole frames of the free-breathing cardiac magnetic resonance, supplemented by visual identification, is time consuming and laborious. We propose a novel method for automatic identification of both the end-diastole and the end-systole frames, in the free-breathing CMR imaging. The proposed technique utilizes the convolutional neural network to locate the left ventricle and to obtain the end-diastole and the end-systole frames from the respiratory motion signal. The proposed procedure works successfully on our free-breathing CMR data, and the results demonstrate a high degree of accuracy and stability. Convolutional neural network improves the postprocessing efficiency greatly and facilitates the clinical application of the free-breathing CMR imaging.
      PubDate: Wed, 26 Jul 2017 09:25:29 +000
  • Kalman Filtering for Genetic Regulatory Networks with Missing Values

    • Abstract: The filter problem with missing value for genetic regulation networks (GRNs) is addressed, in which the noises exist in both the state dynamics and measurement equations; furthermore, the correlation between process noise and measurement noise is also taken into consideration. In order to deal with the filter problem, a class of discrete-time GRNs with missing value, noise correlation, and time delays is established. Then a new observation model is proposed to decrease the adverse effect caused by the missing value and to decouple the correlation between process noise and measurement noise in theory. Finally, a Kalman filtering is used to estimate the states of GRNs. Meanwhile, a typical example is provided to verify the effectiveness of the proposed method, and it turns out to be the case that the concentrations of mRNA and protein could be estimated accurately.
      PubDate: Wed, 26 Jul 2017 08:58:39 +000
  • Computational Paradigms for Mental Health

    • PubDate: Wed, 26 Jul 2017 08:54:28 +000
  • NSiteMatch: Prediction of Binding Sites of Nucleotides by Identifying the
           Structure Similarity of Local Surface Patches

    • Abstract: Nucleotides play a central role in life-form metabolism, by interacting with proteins and mediating the function of proteins. It is estimated that nucleotides constitute about 15% of the biologically relevant ligands included in PDB. Prediction of binding sites of nucleotides is useful in understanding the function of proteins and can facilitate the in silico design of drugs. In this study, we propose a nucleotide-binding site predictor, namely, NSiteMatch. The NSiteMatch algorithm integrates three different strategies: geometrical analysis, energy calculation, and template comparison. Unlike a traditional template-based predictor, which identifies global similarity between target structure and template, NSiteMatch concerns the local similarity between a surface patch of the target protein and the binding sites of template. To this end, NSiteMatch identifies more templates than traditional template-based predictors. The NSiteMatch predictor is compared with three representative methods, Findsite, Q-SiteFinder, and MetaPocket. An extensive evaluation demonstrates that NSiteMatch achieves higher success rates than Findsite, Q-SiteFinder, and MetaPocket, in prediction of binding sites of ATP, ADP, and AMP.
      PubDate: Tue, 25 Jul 2017 00:00:00 +000
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