Subjects -> HEALTH AND SAFETY (Total: 1543 journals)
    - CIVIL DEFENSE (22 journals)
    - DRUG ABUSE AND ALCOHOLISM (87 journals)
    - HEALTH AND SAFETY (725 journals)
    - WOMEN'S HEALTH (82 journals)

PHYSICAL FITNESS AND HYGIENE (130 journals)                     

Showing 1 - 130 of 130 Journals sorted alphabetically
ACSMs Health & Fitness Journal     Full-text available via subscription   (Followers: 15)
Acta Facultatis Educationis Physicae Universitatis Comenianae     Open Access   (Followers: 4)
Acta Kinesiologiae Universitatis Tartuensis     Open Access   (Followers: 1)
ACTIVE : Journal of Physical Education, Sport, Health and Recreation     Open Access   (Followers: 30)
Adapted Physical Activity Quarterly     Hybrid Journal   (Followers: 5)
African Journal for Physical, Health Education, Recreation and Dance     Full-text available via subscription   (Followers: 7)
Ágora para la Educación Física y el Deporte     Open Access  
Al.Qadisiya journal for the Sciences of Physical Education     Open Access  
American Journal of Sexuality Education     Hybrid Journal   (Followers: 4)
Annals of Applied Sport Science     Open Access   (Followers: 10)
Annals of Work Exposures and Health     Hybrid Journal   (Followers: 11)
Applied Physiology, Nutrition and Metabolism     Hybrid Journal   (Followers: 34)
Apunts. Medicina de l'Esport     Full-text available via subscription   (Followers: 1)
Arab Journal of Nutrition and Exercise     Open Access   (Followers: 1)
Archives of Exercise in Health and Disease     Open Access   (Followers: 7)
Arquivos de Ciências do Esporte     Open Access  
Arquivos em Movimento     Open Access   (Followers: 1)
Arrancada     Open Access   (Followers: 1)
Athletic Training & Sports Health Care     Full-text available via subscription   (Followers: 24)
BMC Obesity     Open Access   (Followers: 8)
BMC Sports Science, Medicine and Rehabilitation     Open Access   (Followers: 35)
Childhood Obesity     Hybrid Journal   (Followers: 24)
Clinical Journal of Sport Medicine     Hybrid Journal   (Followers: 36)
Comparative Exercise Physiology     Hybrid Journal   (Followers: 25)
Cultura, Ciencia y Deporte     Open Access   (Followers: 2)
Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity     Hybrid Journal   (Followers: 24)
eJRIEPS : Ejournal de la recherche sur l'intervention en éducation physique et sport     Open Access  
Environmental Health and Preventive Medicine     Open Access   (Followers: 4)
Éthique & Santé     Full-text available via subscription  
Fat Studies : An Interdisciplinary Journal of Body Weight and Society     Partially Free   (Followers: 3)
Fisioterapia em Movimento     Open Access  
Fitness & Performance Journal     Open Access   (Followers: 3)
Food Science and Human Wellness     Open Access   (Followers: 5)
Frontiers in Sports and Active Living     Open Access   (Followers: 2)
Gelanggang Pendidikan Jasmani Indonesia     Open Access  
German Journal of Exercise and Sport Research : Sportwissenschaft     Hybrid Journal   (Followers: 4)
Geron     Full-text available via subscription  
Global Journal of Health and Physical Education Pedagogy     Full-text available via subscription   (Followers: 2)
Health and Quality of Life Outcomes     Open Access   (Followers: 15)
Health Education Journal     Hybrid Journal   (Followers: 17)
Health Marketing Quarterly     Hybrid Journal   (Followers: 3)
Health Physics     Hybrid Journal   (Followers: 7)
Home Healthcare Now     Hybrid Journal   (Followers: 5)
Human Movement     Open Access   (Followers: 14)
Human Movement Science     Hybrid Journal   (Followers: 17)
IISE Transactions on Occupational Ergonomics and Human Factors     Hybrid Journal  
Indonesia Performance Journal     Open Access  
İnönü Üniversitesi Beden Eğitimi ve Spor Bilimleri Dergisi     Open Access  
International Journal for Vitamin and Nutrition Research     Hybrid Journal   (Followers: 12)
International Journal of Applied Exercise Physiology     Open Access   (Followers: 59)
International Journal of Athletic Therapy & Training     Hybrid Journal   (Followers: 15)
International Journal of Behavioral Nutrition and Physical Activity     Open Access   (Followers: 30)
International Journal of Men's Health     Full-text available via subscription   (Followers: 5)
International Journal of Obesity     Hybrid Journal   (Followers: 94)
International Journal of Obesity Supplements     Full-text available via subscription   (Followers: 8)
International Journal of Qualitative Studies on Health and Well-Being     Open Access   (Followers: 21)
International Journal of Spa and Wellness     Hybrid Journal  
International Journal of Sport, Exercise & Training Sciences     Open Access   (Followers: 2)
International Journal of Yoga     Open Access   (Followers: 17)
Isokinetics and Exercise Science     Hybrid Journal   (Followers: 12)
Journal of American College Health     Hybrid Journal   (Followers: 4)
Journal of Athlete Development and Experience     Open Access   (Followers: 1)
Journal of Bioenergetics and Biomembranes     Hybrid Journal   (Followers: 1)
Journal of Human Performance in Extreme Environments     Open Access   (Followers: 2)
Journal of Human Sport and Exercise     Open Access   (Followers: 19)
Journal of Motor Learning and Development     Hybrid Journal  
Journal of Physical Activity and Health     Hybrid Journal   (Followers: 11)
Journal of Physical Activity and Hormones     Open Access   (Followers: 1)
Journal of Physical Activity Research     Open Access   (Followers: 5)
Journal of Physical Education and Human Movement     Open Access  
Journal of Physical Education and Sport Sciences     Open Access   (Followers: 2)
Journal of Physical Education Health and Sport     Open Access   (Followers: 1)
Journal of Physical Education, Recreation & Dance     Full-text available via subscription   (Followers: 15)
Journal of Science in Sport and Exercise     Hybrid Journal   (Followers: 4)
Journal of Sport and Health Science     Open Access   (Followers: 22)
Journal of Sport Sciences and Fitness     Open Access   (Followers: 16)
Journal of Strength and Conditioning Research     Hybrid Journal   (Followers: 77)
Journal of Yoga & Physical Therapy     Open Access   (Followers: 8)
Jurnal Pendidikan Kesehatan Rekreasi     Open Access   (Followers: 3)
Kerbala Magazine of Physical Edu. Seiences     Open Access   (Followers: 2)
Kinesiology : International Journal of Fundamental and Applied Kinesiology     Open Access  
Kinesiology Review     Hybrid Journal   (Followers: 6)
Krankenhaus-Hygiene - Infektionsverhütung     Full-text available via subscription  
Measurement in Physical Education and Exercise Science     Hybrid Journal   (Followers: 7)
Médecine & Nutrition     Full-text available via subscription  
Mental Health and Physical Activity     Hybrid Journal   (Followers: 17)
MHSalud : Movimiento Humano y Salud     Open Access  
Obesity     Hybrid Journal   (Followers: 58)
Obesity Research & Clinical Practice     Full-text available via subscription   (Followers: 21)
Obesity Reviews     Hybrid Journal   (Followers: 26)
Obesity Science & Practice     Open Access   (Followers: 1)
Open Obesity Journal     Open Access   (Followers: 1)
Pain Management in General Practice     Full-text available via subscription   (Followers: 12)
PALAESTRA : Adapted Sport, Physical Education, and Recreational Therapy     Full-text available via subscription   (Followers: 4)
Physical Activity and Health     Open Access   (Followers: 3)
Physical Education & Sport Pedagogy     Hybrid Journal   (Followers: 12)
Preventing Chronic Disease     Free   (Followers: 2)
Psychology of Sport and Exercise     Hybrid Journal   (Followers: 20)
Quality in Sport     Open Access   (Followers: 1)
Race and Yoga     Open Access   (Followers: 5)
RBNE - Revista Brasileira de Nutrição Esportiva     Open Access   (Followers: 1)
RBONE - Revista Brasileira de Obesidade, Nutrição e Emagrecimento     Open Access  
RBPFEX - Revista Brasileira de Prescrição e Fisiologia do Exercício     Open Access  
Research Quarterly for Exercise and Sport     Hybrid Journal   (Followers: 1)
Retos : Nuevas Tendencias en Educación Física, Deportes y Recreación     Open Access  
Revista Andaluza de Medicina del Deporte     Open Access   (Followers: 2)
Revista Brasileira de Atividade Física & Saúde     Open Access  
Revista Brasileira de Ciências do Esporte     Open Access   (Followers: 1)
Revista Brasileira de Cineantropometria & Desempenho Humano     Open Access   (Followers: 1)
Revista Brasileira de Educação Física e Esporte     Open Access   (Followers: 2)
Revista da Educação Física : UEM     Open Access   (Followers: 1)
Revista Iberoamericana de Psicología del Ejercicio y el Deporte     Open Access  
Revista Internacional de Medicina y Ciencias de la Actividad Física y del Deporte : International Journal of Medicine and Science of Physical Activity and Sport     Open Access   (Followers: 1)
Revue phénEPS / PHEnex Journal     Open Access  
Scandinavian Journal of Sport and Exercise Psychology     Open Access   (Followers: 8)
SIPATAHOENAN : South-East Asian Journal for Youth, Sports & Health Education     Open Access  
Spor Bilimleri Dergisi / Hacettepe Journal of Sport Sciences     Open Access  
Sport and Fitness Journal     Open Access   (Followers: 5)
Sport Health     Full-text available via subscription   (Followers: 3)
Sport Sciences for Health     Hybrid Journal   (Followers: 5)
Sport- und Präventivmedizin     Hybrid Journal   (Followers: 3)
SPORTIVE : Journal Of Physical Education, Sport and Recreation     Open Access   (Followers: 5)
Sports     Open Access   (Followers: 2)
Sports Biomechanics     Hybrid Journal   (Followers: 29)
Sports Health: A Multidisciplinary Approach     Hybrid Journal   (Followers: 4)
Strength & Conditioning Journal     Hybrid Journal   (Followers: 64)
Timisoara Physical Education and Rehabilitation Journal     Open Access   (Followers: 4)
Turkish Journal of Sport and Exercise     Open Access  
Yoga Mimamsa     Open Access   (Followers: 2)
Здоровье человека, теория и методика физической культуры и спорта     Open Access  


Similar Journals
Journal Cover
Obesity Research & Clinical Practice
Journal Prestige (SJR): 0.682
Citation Impact (citeScore): 2
Number of Followers: 21  
  Full-text available via subscription Subscription journal
ISSN (Print) 1871-403X - ISSN (Online) 1878-0318
Published by Elsevier Homepage  [3201 journals]
  • Osteopontin in the pathophysiology of obesity: Is Opn a fat cell foe'
    • Authors: Stephen Fitter; Andrew C.W. Zannettino
      Pages: 249 - 250
      Abstract: Publication date: May–June 2018
      Source:Obesity Research & Clinical Practice, Volume 12, Issue 3
      Author(s): Stephen Fitter, Andrew C.W. Zannettino

      PubDate: 2018-06-18T22:26:30Z
      DOI: 10.1016/j.orcp.2018.06.004
      Issue No: Vol. 12, No. 3 (2018)
  • Comprehensive determinants of growth trajectories and body composition in
           school children: A longitudinal cohort study
    • Authors: Hsien-Yu Fan; Yungling Leo Lee; Shwu-Huey Yang; Yi-Wen Chien; Jane C.-J. Chao; Yang-Ching Chen
      Pages: 270 - 276
      Abstract: Publication date: May–June 2018
      Source:Obesity Research & Clinical Practice, Volume 12, Issue 3
      Author(s): Hsien-Yu Fan, Yungling Leo Lee, Shwu-Huey Yang, Yi-Wen Chien, Jane C.-J. Chao, Yang-Ching Chen
      Objective To fully explain the dynamic and comprehensive etiology of the trajectory associated with adiposity indices. Methods This study involved data of 5572 children, aged 6–11 years, as part of the Taiwan Children Health Study (TCHS). The present study introduced four distinct BMI trajectories, identified previously among children: persistently healthy weight; late-onset overweight or obesity; persistent overweight or obesity; and declining BMI class. Logistic regression was used to examine the effect of non-modifiable factors on BMI trajectory classes. Generalized estimating equations were used to examine the effect of dynamically modifiable factors on either BMI trajectory classes or adiposity indices. Results Compared with class 1 (persistently healthy weight), class 2 exhibited a significantly increased risk of weight gain and fat mass, affected by lower family incomes and poor-quality sleep. Class 3 had a higher risk of persistent obesity and abdominal obesity, affected by higher birthweight and sedentary lifestyle. Class 4 approached a healthy weight due to increased physical activity, which was associated with a decrease in body fat and central obesity. Conclusions We found crucially non-modifiable and modifiable factors that could describe each high BMI growth pattern, and calculated their modifiable contributions to adiposity indices. Modifiable factors that focus on those crucially dynamic factors are recommended for preventing obese growth trajectories.

      PubDate: 2018-06-18T22:26:30Z
      DOI: 10.1016/j.orcp.2017.11.006
      Issue No: Vol. 12, No. 3 (2018)
  • Longitudinal associations of the alternative and terminal pathways of
           complement activation with adiposity: The CODAM study
    • Authors: Ying Xin; Elisabeth Hertle; Carla J.H. van der Kallen; Casper G. Schalkwijk; Coen D.A. Stehouwer; Marleen M.J. van Greevenbroek
      Pages: 286 - 292
      Abstract: Publication date: May–June 2018
      Source:Obesity Research & Clinical Practice, Volume 12, Issue 3
      Author(s): Ying Xin, Elisabeth Hertle, Carla J.H. van der Kallen, Casper G. Schalkwijk, Coen D.A. Stehouwer, Marleen M.J. van Greevenbroek
      Objective To investigate longitudinal associations of components of the alternative (C3, C3a, Bb, factor D [FD], factor H [FH], and properdin) and the terminal complement pathway (C5a, sC5b-9) with adiposity. Methods A prospective human cohort study (n=574 at baseline, n=489 after 7 years follow-up) was analyzed. Generalized estimating equations were used to evaluate the longitudinal associations between complement components (standardized values) and adiposity (main outcome BMI [kg/m2]). Multiple linear regression models were used to investigate the associations between change in complement levels and change in BMI. Analyses were adjusted for age, sex, medication and lifestyle. Results Over the 7-year period, baseline C3 was positively associated with BMI (β=1.72 [95% confidence interval (CI): 1.35; 2.09]). Positive associations were also observed for C3a (β=0.64 [0.31; 0.97]), FD (β=1.00 [0.59; 1.42]), FH (β=1.17 [0.82; 1.53]), and properdin (β=0.60 [0.28; 0.92]), but not for Bb, C5a or sC5b-9. Moreover, changes in C3 (β=0.52 [0.34; 0.71]) and FH (β=0.51 [0.32; 0.70]) were significantly associated with changes in BMI. Conclusions The complement system, particularly activation of the alternative pathway, may be involved in development of adiposity. Whether individual aspects of alternative pathway activation have a causal role in human obesity, remains to be investigated.

      PubDate: 2018-06-18T22:26:30Z
      DOI: 10.1016/j.orcp.2017.11.002
      Issue No: Vol. 12, No. 3 (2018)
  • Do factors related to participation in physical activity change following
           restrictive bariatric surgery' A qualitative study
    • Authors: Juliana Zabatiero; Anne Smith; Kylie Hill; Jeffrey M. Hamdorf; Susan F. Taylor; Martin S. Hagger; Daniel F. Gucciardi
      Pages: 307 - 316
      Abstract: Publication date: May–June 2018
      Source:Obesity Research & Clinical Practice, Volume 12, Issue 3
      Author(s): Juliana Zabatiero, Anne Smith, Kylie Hill, Jeffrey M. Hamdorf, Susan F. Taylor, Martin S. Hagger, Daniel F. Gucciardi
      Aims To explore participants’ ability to participate in physical activity (PA), and barriers and facilitators to PA, at 12 months following restrictive bariatric surgery, and how these differed from participants’ pre-surgery perceptions. Motivators for PA post-surgery were also explored. Methods Qualitative one-on-one in-depth interviews were conducted pre- and 12 months post-surgery. Data were analysed using inductive thematic analysis. Results Fourteen adults (12 females), with a mean (range) age of 41.4 years (25.0–56.0), body mass index (BMI) of 31.7kg/m2 (22.3–48.2), and excess weight loss of 66% (2–127) completed both interviews. Lack of participation in PA during the first 3–6 months post-surgery was a common theme. Although participants reported increased ability to participate in PA, attributing this to a reduction in obesity-related physical barriers to PA, many participants reported that some pre-surgery obesity-related barriers to PA remained at 12 months post-surgery. For most participants, pre-surgery non-obesity related barriers to PA also remained at 12 months post-surgery. Facilitators to PA were consistent pre- and post-surgery. Weight loss and improvement in physical appearance were the most common motivators for PA post-surgery. Conclusions At 12 months following surgery, many participants reported residual obesity and non-obesity related barriers to PA. These barriers may explain the small, if any, pre- to post-surgery change in PA levels reported by earlier research. Facilitators to PA did not change and post-surgery motivators for PA were mostly esteem-related. These data are relevant to shape interventions aimed at optimising PA in this population.

      PubDate: 2018-06-18T22:26:30Z
      DOI: 10.1016/j.orcp.2017.11.001
      Issue No: Vol. 12, No. 3 (2018)
  • DNA sequencing and copy number variation analysis of MCHR2 in a cohort of
           Prader Willi like (PWL) patients
    • Authors: Ellen Geets; Evi Aerts; An Verrijken; Kim Van Hoorenbeeck; Stijn Verhulst; Luc Van Gaal; Wim Van Hul
      Pages: 158 - 166
      Abstract: Publication date: March–April 2018
      Source:Obesity Research & Clinical Practice, Volume 12, Issue 2
      Author(s): Ellen Geets, Evi Aerts, An Verrijken, Kim Van Hoorenbeeck, Stijn Verhulst, Luc Van Gaal, Wim Van Hul
      Background Prader Willi Syndrome (PWS) is a syndromic form of obesity caused by a chromosomal aberration on chromosome 15q11.2–q13. Patients with a comparable phenotype to PWS not carrying the 15q11.2–q13 defect are classified as Prader Willi like (PWL). In literature, PWL patients do frequently harbor deletions at 6q16, which led to the identification of the single-minded 1 (SIM1) gene as a possible cause for the presence of obesity in these patients. However, our previous work in a PWL cohort showed a rather limited involvement of SIM1 in the obesity phenotype. In this paper, we investigated the causal role of the melanin-concentrating hormone receptor 2 (MCHR2) gene in PWL patients, as most of the reported 6q16 deletions also encompass this gene and it is suggested to be active in the control of feeding behavior and energy metabolism. Methods Copy number variation analysis of the MCHR2 genomic region followed by mutation analysis of MCHR2 was performed in a PWL cohort. Results Genome-wide microarray analysis of 109 patients with PWL did not show any gene harboring deletions on chromosome 6q16. Mutation analysis in 92 patients with PWL demonstrated three MCHR2 variants: p.T47A (c.139A>G), p.A76A (c.228T>C) and c.*16A>G. We identified a significantly higher prevalence of the c.228T>C C allele in our PWL cohort compared to previously published results and controls of the ExAC Database. Conclusion Overall, our results are in line with some previously performed studies suggesting that MCHR2 is not a major contributor to human obesity and the PWL phenotype.

      PubDate: 2018-05-29T01:01:22Z
      DOI: 10.1016/j.orcp.2017.10.001
      Issue No: Vol. 12, No. 2 (2018)
  • Gene expression profiles in whole blood and associations with metabolic
           dysregulation in obesity
    • Authors: Amanda J. Cox; Ping Zhang; Tiffany J. Evans; Rodney J. Scott; Allan W. Cripps; Nicholas P. West
      Pages: 204 - 213
      Abstract: Publication date: March–April 2018
      Source:Obesity Research & Clinical Practice, Volume 12, Issue 2
      Author(s): Amanda J. Cox, Ping Zhang, Tiffany J. Evans, Rodney J. Scott, Allan W. Cripps, Nicholas P. West
      Background Gene expression data provides one tool to gain further insight into the complex biological interactions linking obesity and metabolic disease. This study examined associations between blood gene expression profiles and metabolic disease in obesity. Methods Whole blood gene expression profiles, performed using the Illumina HT-12v4 Human Expression Beadchip, were compared between (i) individuals with obesity (O) or lean (L) individuals (n=21 each), (ii) individuals with (M) or without (H) Metabolic Syndrome (n=11 each) matched on age and gender. Enrichment of differentially expressed genes (DEG) into biological pathways was assessed using Ingenuity Pathway Analysis. Association between sets of genes from biological pathways considered functionally relevant and Metabolic Syndrome were further assessed using an area under the curve (AUC) and cross-validated classification rate (CR). Results For OvL, only 50 genes were significantly differentially expressed based on the selected differential expression threshold (1.2-fold, p<0.05). For MvH, 582 genes were significantly differentially expressed (1.2-fold, p<0.05) and pathway analysis revealed enrichment of DEG into a diverse set of pathways including immune/inflammatory control, insulin signalling and mitochondrial function pathways. Gene sets from the mTOR signalling pathways demonstrated the strongest association with Metabolic Syndrome (p=8.1×10−8; AUC: 0.909, CR: 72.7%). Conclusions These results support the use of expression profiling in whole blood in the absence of more specific tissue types for investigations of metabolic disease. Using a pathway analysis approach it was possible to identify an enrichment of DEG into biological pathways that could be targeted for in vitro follow-up.

      PubDate: 2018-05-29T01:01:22Z
      DOI: 10.1016/j.orcp.2017.07.001
      Issue No: Vol. 12, No. 2 (2018)
  • Exclusive breastfeeding and partial breastfeeding reduce the risk of
           overweight in childhood: A nationwide longitudinal study in Korea
    • Authors: Seon-Joo Park; Hae-Jeung Lee
      Pages: 222 - 228
      Abstract: Publication date: March–April 2018
      Source:Obesity Research & Clinical Practice, Volume 12, Issue 2
      Author(s): Seon-Joo Park, Hae-Jeung Lee
      Objective Breastfeeding is generally known to reduce the risk of childhood overweight and obesity. However, the results are controversial between countries, and nationwide data are rare. This study assessed the relationship between breastfeeding types and overweight incidence using nationwide longitudinal data in Korea. Methods We analysed 774,764 infants who participated in the longitudinal nationwide data from the Korea National Children’s Health Examination 2007–2013. Childhood overweight was defined by a Z-score≥1.64 (95th centile) for infants under 24 months and Z-scores≥1.04 (85th centile) for children over 24 months. Cox proportional hazard model was used to analyse the relationship between breastfeeding types and overweight incidence. Results Infants who were exclusively breastfed at 4–6 months of age had the multivariate-adjusted hazard ratio (HRs) for overweight of 0.78 (95% CI 0.77–0.79) and infants who were partially breastfed had the HRs for overweight of 0.96 (95% CI 0.94–0.98), which was lower compared to that of the exclusively formula fed group. Similar results were obtained for stratified analysis by boys and girls. Conclusions Exclusive and partial breastfeeding have preventive effect on childhood overweight in Korea. Therefore, it is necessary to encourage breastfeeding to prevent childhood obesity and its consequences in developed Asian countries.

      PubDate: 2018-05-31T10:47:12Z
      DOI: 10.1016/j.orcp.2018.01.001
      Issue No: Vol. 12, No. 2 (2018)
  • DP1 receptor agonist, BW245C inhibits diet-induced obesity in
           ApoE−/− mice
    • Authors: Sunil Kumar; Thomas Palaia; Christopher Hall; Louis Ragolia
      Pages: 229 - 241
      Abstract: Publication date: March–April 2018
      Source:Obesity Research & Clinical Practice, Volume 12, Issue 2
      Author(s): Sunil Kumar, Thomas Palaia, Christopher Hall, Louis Ragolia
      Background/objective Lipocalin Prostaglandin D2 synthase (LPGDS) contributes to the production of PGD2, which has been associated with adipogenesis. In this study, we aimed to investigate the role of PGD2 on obesity through its DP1 and DP2 receptor signaling using intraperitoneal injection of their respective agonists and antagonists. Methods ApoE−/− mice were divided into five groups: vehicle control (n=5), DP1 receptor agonist (n=5), DP1 receptor antagonist (n=5), DP2 receptor agonist (n=5), and DP2 receptor antagonist (n=5), and the study was carried out for 10 weeks. Results Despite being on high fat diet, mice receiving DP1 receptor agonist sustained a significant inhibition of weight gain throughout the study gaining only 11.4% body weight compared to the controls gaining 61% body weight. Interestingly, parallel to the body weight, the DP1 receptor agonist group showed a significant reduction in food intake throughout the study. Consistently, fasting leptin, insulin and bile acids levels were elevated in the DP1 receptor agonist group compared to controls. As expected, there was a significant reduction in fasting glucose level in DP1 receptor agonist group. At last, as a result of weight gain inhibition, DP1 receptor agonist also imparted cardiovascular benefits showing significant reduction in aortic wall thickness, intima, adventia and lumen size. Conclusion Based on the obtained results, we believe DP1 receptor agonism inhibited diet induced weight gain possibly through controlling appetite which consequently imparted beneficial cardiometabolic effects. DP1 receptor agonism may represent a novel therapeutic target for the management of obesity.

      PubDate: 2018-05-29T01:01:22Z
      DOI: 10.1016/j.orcp.2017.05.003
      Issue No: Vol. 12, No. 2 (2018)
  • Body mass index and the visceral adipose tissue expression of IL-6 and
           TNF-alpha are associated with the morphological severity of non-alcoholic
           fatty liver disease in individuals with class III obesity
    • Authors: Antônio Sérgio Barcala Jorge; João Marcus Oliveira Andrade; Alanna Fernandes Paraíso; Gislaine Candida Batista Jorge; Christine Mendes Silveira; Ludmilla Regina de Souza; Erivelton Pereira Santos; André Luiz Sena Guimaraes; Sérgio Henrique Sousa Santos; Alfredo Maurício Batista De-Paula
      Pages: 1 - 8
      Abstract: Publication date: January–February 2018
      Source:Obesity Research & Clinical Practice, Volume 12, Issue 1, Supplement 1
      Author(s): Antônio Sérgio Barcala Jorge, João Marcus Oliveira Andrade, Alanna Fernandes Paraíso, Gislaine Candida Batista Jorge, Christine Mendes Silveira, Ludmilla Regina de Souza, Erivelton Pereira Santos, André Luiz Sena Guimaraes, Sérgio Henrique Sousa Santos, Alfredo Maurício Batista De-Paula
      Objectives To analyze the mRNA expression of interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-α) in the liver and white adipose tissue samples of individuals with class III obesity (body mass index ≥40.0kg/m2) with non-alcoholic fatty liver disease (NAFLD). Methods This cross-sectional study included patients with class III obesity exhibiting early or late morphological presentation of NAFLD (non-alcoholic hepatic steatosis [NAFL], n =8 and non-alcoholic steatohepatitis [NASH], n =13, respectively). All patients underwent bariatric surgery and peripheral blood, liver, and visceral white adipose tissue (WAT) samples were collected. Socio-demographic, anthropometric, clinical, plasma biochemical, and nutritional characteristics of each study subject were assessed and compared between patients presenting with NAFL and NASH. IL-6 and TNF-α mRNA expression in the liver and WAT samples were measured by using quantitative real time-polymerase chain reaction (qRT-PCR). Results Individuals with class III obesity and NASH showed higher body mass index (BMI) and higher IL-6 and TNF-α mRNA expression in the WAT compared to that of patients with NAFL (p =0.01, for all associations). Conclusions Individuals with class III obesity with higher morphological severity of NAFLD exhibited higher BMI and higher IL-6 and TNF-α expression in the WAT. Future prospective studies are warranted to determine how BMI, IL-6, and TNF-α affect the progression of NAFLD in individuals with class III obesity.

      PubDate: 2018-04-11T12:41:08Z
      DOI: 10.1016/j.orcp.2016.03.009
      Issue No: Vol. 12, No. 1 (2018)
  • Over-under topsy-turvy — what’s the deal with “healthy
    • Authors: Gary Wittert; Brett Huang
      Pages: 1 - 3
      Abstract: Publication date: January–February 2018
      Source:Obesity Research & Clinical Practice, Volume 12, Issue 1
      Author(s): Gary Wittert, Brett Huang

      PubDate: 2018-02-26T02:44:05Z
      DOI: 10.1016/j.orcp.2018.02.001
      Issue No: Vol. 12, No. 1 (2018)
  • Relationship between serum betatrophin levels and the first-phase of
           glucose-stimulated insulin secretion
    • Authors: Dan Liu; Hua Qu; Hang Wang; Yang Duan; Fang Liu; Zhengping Feng; Huacong Deng
      Pages: 9 - 15
      Abstract: Publication date: January–February 2018
      Source:Obesity Research & Clinical Practice, Volume 12, Issue 1, Supplement 1
      Author(s): Dan Liu, Hua Qu, Hang Wang, Yang Duan, Fang Liu, Zhengping Feng, Huacong Deng
      Aims To examine circulating betatrophin concentrations in subjects with different glucose tolerance status and to investigate the relationship between serum betatrophin levels and first-phase of glucose-stimulated insulin secretion. Methods Serum betatrophin concentrations were measured in 110 age- and sex-matched subjects: 47 newly diagnosed type 2 diabetes mellitus (T2DM), 29 impaired glucose tolerance (IGT) and 34 normal glucose tolerance (NGT). Oral glucose tolerance test and intravenous glucose tolerance test were performed to assess glucose tolerance and first-phase of glucose-stimulated insulin secretion. Results Serum betatrophin levels were significantly higher in the T2DM and IGT group than in the NGT group (2.10±1.16ng/mL vs 0.77±0.44ng/mL, 1.73±1.28ng/mL vs 0.77±0.44ng/mL; P <0.01). The AIR and AUC among the three groups showed a progressive decrease from the NGT to IGT group with the lowest value in the T2DM group (P <0.01). Betatrophin were found to be positively correlated with BMI, waist circumference (WC), homeostatic model assessment of insulin resistance (HOMA-IR) and triglyceride (TG), and inversely associated with HDL-c (all P <0.01), but not significantly correlated with 0–10min insulin the area under the curve (AUC) and acute insulin response (AIR) (P >0.05). Stepwise multiple regression analysis showed that HOMA-IR and TG were independently related to betatrophin (P <0.05). Conclusion Serum betatrophin concentrations were higher in T2DM and IGT, and were closely related to glucolipid disorder, insulin resistance, but not related to the first-phase of glucose-stimulated insulin secretion.

      PubDate: 2018-04-11T12:41:08Z
      DOI: 10.1016/j.orcp.2016.08.004
      Issue No: Vol. 12, No. 1 (2018)
  • 5-HT 2 receptor mediates high-fat diet-induced hepatic steatosis and very
           low density lipoprotein overproduction in rats
    • Authors: Xin Li; Keke Guo; Tao Li; Shaoxin Ma; Shanshan An; Shanshan Wang; Jiao Di; Siyu He; Jihua Fu
      Pages: 16 - 28
      Abstract: Publication date: January–February 2018
      Source:Obesity Research & Clinical Practice, Volume 12, Issue 1, Supplement 1
      Author(s): Xin Li, Keke Guo, Tao Li, Shaoxin Ma, Shanshan An, Shanshan Wang, Jiao Di, Siyu He, Jihua Fu
      Background 5-HT has been shown to mediate abnormality of hepatic lipid metabolism through activation of mammalian target of rapamycin (mTOR). However, it is unclear whether 5-HT is directly involved in high-fat diet (HFD)-induced hepatic steatosis. Materials and methods Male rats were allocated into seven groups with control, either HFD feeding, 5-HT treatment, or HFD feeding and 5-HT treatment with or without sarpogrelate treatment, all of which were executed for 4 weeks. HepG2 cells were exposed to 5-HT or palmitic acid (PA) with or without rapamycin or Sar treatment. Results Rats fed with HFD or exposed to 5-HT led to abnormalities with activated hepatic mTOR-S6K pathway, overproduction of hepatic triglycerides and VLDL with steatosis, and hyperlipidemia, which were exacerbated by a combination of HFD and 5-HT. Sarpogrelate significantly inhibited above abnormalities induced by HFD and 5-HT, alone or in a combination. Additionally, HFD caused up-regulation of 5-HT2 receptors (5-HT2R), including 5-HT2AR and 5-HT2BR, and 5-HT synthesis in the liver, without obvious influence on other 5-HT receptors gene expression. In HepG2 cells, both PA and 5-HT induced overproduction of triglycerides and VLDL with lipid droplets, and PA up-regulated 5-HT2AR and 5-HT2BR expression and 5-HT synthesis as well. Rapamycin fully abolished PA or 5-HT-induced mTOR activation, which was more effective than sarpogrelate. However, the inhibitory effects of rapamycin on PA or 5-HT-induced overproduction of triglycerides and VLDL were less than sarpogrelate. Conclusions Up-regulation of hepatic 5-HT2R and 5-HT synthesis by HFD is crucial for HFD-induced overproduction of hepatic triglycerides and VLDL with hyperlipidemia.

      PubDate: 2018-04-11T12:41:08Z
      DOI: 10.1016/j.orcp.2016.03.015
      Issue No: Vol. 12, No. 1 (2018)
  • Fish oil and fenofibrate inhibit pancreatic islet hypertrophy, and improve
           glucose and lipid metabolic dysfuntions with different ways in diabetic KK
    • Authors: Maki Nakasatomi; Hyounju Kim; Takeshi Arai; Satoshi Hirako; Seiji Shioda; Yuzuru Iizuka; Koji Sakurai; Akiyo Matsumoto
      Pages: 29 - 38
      Abstract: Publication date: January–February 2018
      Source:Obesity Research & Clinical Practice, Volume 12, Issue 1, Supplement 1
      Author(s): Maki Nakasatomi, Hyounju Kim, Takeshi Arai, Satoshi Hirako, Seiji Shioda, Yuzuru Iizuka, Koji Sakurai, Akiyo Matsumoto
      We examined the effects of fish oil and fenofibrate (FF) on the pancreatic islet hypertrophy, and on the modification of glucose and lipid metabolic dysfunctions in KK mice with insulin resistance. The mice were fed one of four diets [25en% lard/safflower oil (LSO), 25en% fish oil (FO), or each of these diets plus 0.1wt% FF (LSO/FF, FO/FF)] for 9 weeks. FO group and both FF groups had significantly lower final body and adipose tissue weights than LSO group. Pancreatic islet hypertrophy was observed only in LSO group but not in the other groups with fish oil or FF. And, it is likely that fish oil has a stronger therapeutic effect on islet hypertrophy. Plasma adiponectin level was significantly higher in FO group but not in both FF groups. Expression of hepatic lipogenic enzyme genes such as fatty acid synthase (FAS) and stearoyl-CoA desaturase-1 (SCD-1) was lower in FO groups with or without FF, whereas fatty acid oxidation-related mRNAs such as acyl-CoA oxidase (AOX) and uncoupling protein-2 (UCP-2) were more abundant in FF groups with or without fish oil. Our results suggest that both fish oil and FF improve pancreatic islet hypertrophy with the amelioration of insulin resistance. Fish oil enhances insulin sensitivity by increasing plasma adiponectin; however, the beneficial effect of FF on insulin resistance seems to be independent of the plasma adiponectin level. These results mean that improvement of glucose and lipid metabolic dysfuctions in diabetic KK mice are independently approached by fish oil and FF.

      PubDate: 2018-04-11T12:41:08Z
      DOI: 10.1016/j.orcp.2016.03.012
      Issue No: Vol. 12, No. 1 (2018)
  • Role of adiponectin gene variants, adipokines and hydrometry-based percent
           body fat in metabolically healthy and abnormal obesity
    • Authors: Chin-Sung Chang; Yan-Jia Lu; Hsiu-Hao Chang; Shih-Han Hsu; Po-Hsiu Kuo; Chi-Chang Shieh; Wei-Jen Yao; Mei-Chi Hsu; Kung-Chia Young; Wen-Yuan Lin; Kuo-Chin Huang; Chih-Hsing Wu; Yau-Sheng Tsai
      Pages: 49 - 61
      Abstract: Publication date: January–February 2018
      Source:Obesity Research & Clinical Practice, Volume 12, Issue 1, Supplement 1
      Author(s): Chin-Sung Chang, Yan-Jia Lu, Hsiu-Hao Chang, Shih-Han Hsu, Po-Hsiu Kuo, Chi-Chang Shieh, Wei-Jen Yao, Mei-Chi Hsu, Kung-Chia Young, Wen-Yuan Lin, Kuo-Chin Huang, Chih-Hsing Wu, Yau-Sheng Tsai
      Objective Metabolically healthy obesity (MHO) subjects have better metabolic parameters than metabolically abnormal obesity (MAO) subjects, but the possible mechanisms underlying this remain unknown. Our study was designed to investigate the interrelationships among genes, adipokines, body fat and its distribution in MHO and MAO. Methods From 2007 to 2009, 103 males and 131 females aged 18–50 years were enrolled by an intention-to-treat design in a weight management clinic. Participants were divided into MHO and MAO groups. Percent body fat (PBF) was measured by a deuterium oxide dilution method. Four polymorphic variants, including PPARγ2 (Pro12Ala and C1431T) and adiponectin (T45G and G276T) genes, and three adipokines (adiponectin, leptin and resistin) were obtained. Results Of the 234 obese subjects, 130 (55.6%) were MHO. In the univariate analysis, the MAO group has significantly higher anthropometric, metabolic indices and leptin levels than the MHO group. Logistic regression analysis revealed that age, male gender, the T allele of adiponectin T45G polymorphism, leptin and PBF were positively associated with MAO. ANCOVA analysis revealed that the T allele of adiponectin T45G polymorphism was associated with higher fasting and postprandial glucose levels. We further found that TT genotype has a lower high molecular weight (HMW)/low molecular weight (LMW) adiponectin ratio than GG genotype. Conclusions The factors associated with MAO are age, male gender, the T allele of adiponectin T45G polymorphism, leptin, and PBF. The net effects of T45G polymorphism on the MAO phenotype may be achieved by changes in the adiponectin oligomer ratio and glucose levels.

      PubDate: 2018-04-11T12:41:08Z
      DOI: 10.1016/j.orcp.2016.05.003
      Issue No: Vol. 12, No. 1 (2018)
  • The sagittal abdominal diameter: Role in predicting severe liver disease
           in the general population
    • Authors: Fredrik Åberg; Antti Jula
      Abstract: Publication date: Available online 30 June 2018
      Source:Obesity Research & Clinical Practice
      Author(s): Fredrik Åberg, Antti Jula
      The role of the sagittal abdominal diameter (SAD) as a predictor of incident liver disease is unknown. 6626 individuals from the Finnish population-based Health 2000 Study were linked with national registers for liver-related admissions, mortality and cancer. SAD predicted incident liver disease (HR 1.32, 95% CI 1.06–1.65) when adjusted for age and sex, but the association was weaker than for waist–hip ratio (HR 1.86, 95% CI 1.35–2.55), waist circumference (HR 1.42, 95% CI 1.12–1.81), and waist–height ratio (HR 1.44, 95% CI 1.12–1.87); BMI was non-significant. In conclusion, SAD provided no additional benefit to other obesity measures in predicting incident severe liver disease.

      PubDate: 2018-07-01T01:01:53Z
      DOI: 10.1016/j.orcp.2018.06.007
  • Predictors of postpartum weight retention among urban Malaysian mothers: A
           prospective cohort study
    • Authors: Fariza Fadzil; Khadijah Shamsuddin; Sharifa Ezat Wan Puteh; Azmi Mohd Tamil; Shuhaila Ahmad; Noor Shaheeran Abdul Hayi; Azah Abdul Samad; Ruhaini Ismail; Nor Izzah Ahmad Shauki
      Abstract: Publication date: Available online 28 June 2018
      Source:Obesity Research & Clinical Practice
      Author(s): Fariza Fadzil, Khadijah Shamsuddin, Sharifa Ezat Wan Puteh, Azmi Mohd Tamil, Shuhaila Ahmad, Noor Shaheeran Abdul Hayi, Azah Abdul Samad, Ruhaini Ismail, Nor Izzah Ahmad Shauki
      Background Women of childbearing age are predisposed to becoming overweight or obese. This study determines the mean, prevalence and factors associated with 6 months postpartum weight retention among urban Malaysian mothers. Methods A prospective cohort study was conducted at baseline (after delivery), 2, 4 and 6 months postpartum. From 638 eligible mothers initially recruited, 420 completed until 6 months. Dependent variable was weight retention, defined as difference between weight at 6 months postpartum and pre-pregnancy weight, and weight retention ≥5kg was considered excessive. Independent variables included socio-demographic, history of pregnancy and delivery, lifestyle, practices and traditional postpartum practices. Results Average age was 29.61±4.71years, majority (83.3%) were Malays, 58.8% (low education), 70.0% (employed), 65.2% (middle income family), 33.8% (primiparous) and 66.7% (normal/instrumental delivery). Average gestational weight gain was 12.90±5.18kg. Mean postpartum weight retention was 3.12±4.76kg, 33.8% retaining ≥5kg. Bivariable analysis showed low income, primiparity, gestational weight gain ≥12kg, less active physically, higher energy, protein, carbohydrate and fat intake in diet, never using hot stone compression and not continuing breastfeeding were significantly associated with higher 6 months postpartum weight retention. From multivariable linear regression analysis, less active physically, higher energy intake in diet, gestational weight gain ≥12kg, not continuing breastfeeding 6 months postpartum and never using hot stone compression could explain 55.1% variation in 6 months postpartum weight retention. Conclusion Women need to control gestational weight gain, remain physically active, reduce energy intake, breastfeed for at least 6 months and use hot stone compression to prevent high postpartum weight retention.

      PubDate: 2018-07-01T01:01:53Z
      DOI: 10.1016/j.orcp.2018.06.003
  • Adverse effects of long-term weight gain on microvascular endothelial
    • Authors: Thais Coutinho; Stephen T. Turner; Iftikhar J. Kullo
      Abstract: Publication date: Available online 28 June 2018
      Source:Obesity Research & Clinical Practice
      Author(s): Thais Coutinho, Stephen T. Turner, Iftikhar J. Kullo
      Background Endothelial dysfunction is the first stage of the atherosclerotic cascade, and independently associated with cardiovascular events. We evaluated the associations of longitudinal changes in weight, waist circumference, body fat percentage and lean mass index with changes in endothelial function. Methods 521 community-based subjects who belonged to hypertensive sibships and had no history of myocardial infarction or stroke had their anthropometric measures and endothelial function assessed a mean of 8.5 years apart. Endothelial function was assessed with brachial artery ultrasound, yielding measures of flow-mediated dilation and reactive hyperemia. We used multivariable linear regression with generalised estimating equations to assess the associations of longitudinal changes (Δ) in anthropometric measures with Δ flow-mediated dilation and reactive hyperemia, adjusting for potential confounders. Results Mean±standard deviation age was 57.6±8.7years, 58% were women, and 72% were hypertensive. Most (84%) were overweight or obese at baseline. At end of follow-up, flow-mediated dilation and reactive hyperemia increased by 1.9±7.6% and 51.2±605.8% on average, respectively. In multivariable linear regression, changes in anthropometric measures were not associated with changes in flow-mediated dilation. However, Δ weight (β ±SE: −9.00±2.35), Δ waist circumference (−6.78±2.21) and Δ body fat percentage (−19.72±5.62, P <0.0001 for each) were inversely associated with Δ reactive hyperemia. Δ lean mass index was not associated with Δ reactive hyperemia. Conclusions Long-term increases in weight, waist circumference and body fat percentage are associated with progressive worsening of microvascular endothelial function, but not conduit vessel endothelial function, in subjects without a history of cardiovascular events, independently of risk factors.

      PubDate: 2018-07-01T01:01:53Z
      DOI: 10.1016/j.orcp.2018.06.008
  • MiR-122 marks the differences between subcutaneous and visceral adipose
           tissues and associates with the outcome of bariatric surgery
    • Authors: Chien-Hung Liao; Chao-Yung Wang; Keng-Hau Liu; Yu-Yin Liu; Ming-Shien Wen; Ta-Sen Yeh
      Abstract: Publication date: Available online 28 June 2018
      Source:Obesity Research & Clinical Practice
      Author(s): Chien-Hung Liao, Chao-Yung Wang, Keng-Hau Liu, Yu-Yin Liu, Ming-Shien Wen, Ta-Sen Yeh
      The physiological roles and clinical impacts of the differences between visceral fat (VF) and subcutaneous fat (SF) are unclear. The present study aimed to compare the miRNA signatures between visceral fat (VF) and subcutaneous fat (SF) and study their influences on outcomes of bariatric surgery. To study the microRNA signatures of the VF and SF in obesity, we performed paired microRNA arrays of the adipose tissues from 20 bariatric surgery patients. The microRNA analysis identified miR-122 as the most significant signature between VF and SF. The tissue distribution, functions, and influences on adipogensis of miR-122 were analysed by Northern blotting, microRNA mimics and inhibitors, and whole-genome microarray analysis. The outcomes of body weight changes after bariatric surgery were analysed and correlated with the miR-122 abundances. Northern blotting confirmed that miR-122 was highly expressed in VF and SF. Bioinformatics analysis of the microarray revealed that proliferator activator receptor-γ (PPAR-γ) signalling was critically affected by miR-122. The modulation of PPAR-γ by miR-122 was confirmed in murine adipocytes and human adipose tissues. Furthermore, the differentiation of preadipocytes was significantly influenced by miR-122. In obese patients receiving bariatric surgery, the ratio of VF and SF miR-122 abundance correlated with 6-month and 1-year % excess body weight loss. Our findings indicate that miR-122 is highly expressed in adipose tissue. The abundance of miR-122 affects PPAR-γ signalling and adipocytes differentiation in vitro and human adipose tissues. Higher miR-122 in VF may be associated with greater body weight loss after bariatric surgery.

      PubDate: 2018-07-01T01:01:53Z
      DOI: 10.1016/j.orcp.2018.06.005
  • The association of sleep duration and sleep quality with non-alcoholic
           fatty liver disease in a Taiwanese population
    • Authors: Yu-Tsung Chou; Hsiang-Ju Cheng; Jin-Shang Wu; Yi-Ching Yang; Chieh-Ying Chou; Chih-Jen Chang; Feng-Hwa Lu
      Abstract: Publication date: Available online 19 June 2018
      Source:Obesity Research & Clinical Practice
      Author(s): Yu-Tsung Chou, Hsiang-Ju Cheng, Jin-Shang Wu, Yi-Ching Yang, Chieh-Ying Chou, Chih-Jen Chang, Feng-Hwa Lu
      Objective The association of sleep duration/quality with nonalcoholic fatty liver disease (NAFLD) is inconclusive. Several important covariates were not adjusted concomitantly in some studies, and the severity of NAFLD was not considered. Furthermore, the gender impact of sleep duration or sleep quality on NAFLD remains unclear. We thus aimed to examine the association of sleep duration and quality with NAFLD by gender in a Taiwanese population. Methods A total of 6663 subjects aged 18 years or more were enrolled. The severity of NAFLD was divided into mild, moderate, and severe degrees based on ultrasound findings. The sleep duration was classified into three groups: short (<6h), normal (6–8h), and long (>8h). Pittsburgh Sleep Quality Index (PSQI) was used to evaluate sleep quality, and poor sleep quality was defined as a global PSQI score greater than 5. Results After adjustment for potential confounders, multinomial logistic regression showed that poor sleep quality was negatively associated with both mild and moderate-to-severe NAFLD in males, but sleep duration was not independently related to NAFLD. In females, sleep condition was not related to NAFLD. Conclusions Poor sleep quality but not sleep duration was associated with a lower risk of not only moderate to severe but also mild NAFLD in males. In females, the association of sleep quality and duration with the risk of NAFLD was insignificant.

      PubDate: 2018-06-21T08:44:28Z
      DOI: 10.1016/j.orcp.2018.05.002
  • Intensive interdisciplinary treatment for a patient with coexisting pain
           and obesity: A case study
    • Authors: R.B. Perez; S. Dixon; S. Culver; C.D. Sletten
      Abstract: Publication date: Available online 31 May 2018
      Source:Obesity Research & Clinical Practice
      Author(s): R.B. Perez, S. Dixon, S. Culver, C.D. Sletten
      Chronic pain and obesity are topics of increasing concern. When both diagnoses are present in the same patient, treatment can be complicated. This is a retrospective case-study looking at outcomes across the continuum of care for a patient with Grade III Obesity and chronic widespread pain. The patient completed a Pain Rehabilitation Center program. Progression was realised by following a deliberate, daily regimen, allowing for consistent activity despite the presence of significant physical symptoms and emotional distress.

      PubDate: 2018-06-03T05:03:41Z
      DOI: 10.1016/j.orcp.2018.05.003
  • The use of consumer depth cameras for 3D surface imaging of people with
           obesity: A feasibility study
    • Authors: J.S. Wheat; S. Clarkson; S.W. Flint; C. Simpson; D.R. Broom
      Abstract: Publication date: Available online 21 May 2018
      Source:Obesity Research & Clinical Practice
      Author(s): J.S. Wheat, S. Clarkson, S.W. Flint, C. Simpson, D.R. Broom
      Objective Three dimensional (3D) surface imaging is a viable alternative to traditional body morphology measures, but the feasibility of using this technique with people with obesity has not been fully established. Therefore, the aim of this study was to investigate the validity, repeatability and acceptability of a consumer depth camera 3D surface imaging system in imaging people with obesity. Methods The concurrent validity of the depth camera based system was investigated by comparing measures of mid-trunk volume to a gold-standard. The repeatability and acceptability of the depth camera system was assessed in people with obesity at a clinic. Results There was evidence of a fixed systematic difference between the depth camera system and the gold standard but excellent correlation between volume estimates (r2 =0.997), with little evidence of proportional bias. The depth camera system was highly repeatable – low typical error (0.192L), high intraclass correlation coefficient (>0.999) and low technical error of measurement (0.64%). Depth camera based 3D surface imaging was also acceptable to people with obesity. Conclusion It is feasible (valid, repeatable and acceptable) to use a low cost, flexible 3D surface imaging system to monitor the body size and shape of people with obesity in a clinical setting.

      PubDate: 2018-05-29T01:01:22Z
      DOI: 10.1016/j.orcp.2018.05.001
  • LDL cholesterol was more strongly associated with percent body fat than
           body mass index and waist circumference in a health screening population
    • Authors: Eiji Oda
      Abstract: Publication date: March–April 2018
      Source:Obesity Research & Clinical Practice, Volume 12, Issue 2
      Author(s): Eiji Oda
      Aims To compare correlations between changes in cardiovascular risk factors and those in obesity indices and to compare associations with incident hyper-LDL cholesterolemia among obesity indices. Methods Correlation coefficients were calculated between 7-year changes in cardiovascular risk factors and those in body mass index (BMI), waist circumference (WC) and percent body fat (PBF) in 634 men and 396 women who used no antihypertensive, antidiabetic or antihyperlipidemic drugs. Odds ratios of incident hyper-LDL cholesterolemia after 7 years were calculated for BMI, WC and PBF in 738 men and 388 women. Results There were no significant differences in the correlations with 7-year changes in cardiovascular risk factors between 7-year changes in BMI and WC. The correlation with 7-year change in LDL cholesterol was stronger for that in PBF than that in BMI or WC (p=0.021 or 0.089, respectively in men and 0.022 or 0.020, respectively in women). The correlations with 7-year changes in log triglycerides, HDL cholesterol and log high-sensitivity CRP were stronger for those in BMI and WC than that in PBF in men. Incident hyper-LDL cholesterolemia after 7 years was significantly associated with PBF, but not BMI or WC, in men after adjusted for age and other covariates. However, the association was not significant after further adjusted for LDL cholesterol. Conclusions The correlation with 7-year change in LDL cholesterol was stronger for that in PBF than that in BMI or WC. Incident hyper-LDL cholesterolemia was significantly associated with PBF, but not with BMI or WC, in men.

      PubDate: 2018-05-29T01:01:22Z
  • Assessing and counseling the obese patient: Improving resident obesity
           counseling competence
    • Authors: Shwetha Iyer; Melanie Jay; William Southern; Sheira Schlair
      Abstract: Publication date: Available online 16 March 2018
      Source:Obesity Research & Clinical Practice
      Author(s): Shwetha Iyer, Melanie Jay, William Southern, Sheira Schlair
      Objective To evaluate obesity counseling competence among residents in a primary care training program Methods We delivered a 3h obesity curriculum to 28 Primary Care residents and administered a pre-curriculum and post curriculum survey looking specifically at self-assessed obesity counseling competence. Results Nineteen residents completed both the pre curriculum survey and the post curriculum survey. The curriculum had a positive impact on residents’ ability to ascertain patient’s stage of change, use different methods to obtain diet history (including 24h recall, food record or food frequency questionnaire), respond to patient’s questions regarding treatment options, assist patients in setting realistic goals for weight loss based on making permanent lifestyle changes, and use of motivational interviewing to change behavior. When looking at the 5As domains, there was a significant improvement in the domains of Assess, Advise, and Assist. The proportion of residents with a lower level of self-assessed obesity counseling competence reduced from 75% before the curriculum to 37.5% (p=0.04) after the curriculum. Conclusion Our curriculum addressing weight loss counseling using the 5As model increased obesity counseling competence among residents in a primary care internal medicine residency program.

      PubDate: 2018-04-11T12:41:08Z
      DOI: 10.1016/j.orcp.2018.02.007
  • Screening for Binge Eating Disorder in people with obesity
    • Authors: Mirjam C.M. Wever; Alexandra E. Dingemans; Tiny Geerets; Unna N. Danner
      Abstract: Publication date: Available online 9 March 2018
      Source:Obesity Research & Clinical Practice
      Author(s): Mirjam C.M. Wever, Alexandra E. Dingemans, Tiny Geerets, Unna N. Danner
      The Risk factors for Binge Eating Disorder in Overweight (REO) questionnaire is a screening tool for nutritionists to discriminate between individuals with obesity with and without Binge Eating Disorder (BED). The first study tested the discriminative ability of the REO and identified an optimal cut-off value. In the second study this cut-off value was used to identify individuals with and without BED from a sample of individuals with obesity visiting a nutritionist and compared clinical and personality characteristics with a group of individuals officially diagnosed with BED. Results showed that the REO has a sensitivity of 95.1%, specificity of 81.5%, a good internal consistency of α =.96, and an exploratory factor analysis showed four underlying factors of the REO that explained a total variance of 63.7%. Characteristics of individuals with BED symptoms identified by the REO and those officially diagnosed with BED were comparable and differed from individuals with obesity without BED symptoms. By screening individuals with obesity with the REO those presenting with BED symptoms are more easily identified, and can be referred to psychological treatment facilities for further assessment and appropriate treatment.

      PubDate: 2018-04-11T12:41:08Z
      DOI: 10.1016/j.orcp.2018.02.002
  • Obesity and place: Chronic disease in the 500 largest U.S. cities
    • Authors: Kevin M. Fitzpatrick; Xuan Shi; Don Willis; Jill Niemeier
      Abstract: Publication date: Available online 8 March 2018
      Source:Obesity Research & Clinical Practice
      Author(s): Kevin M. Fitzpatrick, Xuan Shi, Don Willis, Jill Niemeier
      Objectives Extant research clearly points to a correlation between place and health, specifically as it pertains to chronic diseases like obesity. The present study examines this relationship among a diverse set of compositional place indicators and obesity rates across census tracts in the 500 largest cities in the United States. Methods Using data compiled from the Robert Wood Johnson Foundation 500 Cities project and the Census’ American Community Survey, the analyses examined aggregate relationships between sociodemographic, socioeconomic, and housing characteristics of census tracts and crude prevalence obesity rates in over 27,000 census tracts located in the 500 largest cities in the United States. Results Multivariate analysis confirms the place-chronic health connection. Regardless of variable groups, deteriorating places with higher concentrations of low-income, minority populations reported more obesity prevalence. Conclusions Place matters. The continuing burden of zip code in the United States for disenfranchised populations will likely continue to force policymakers to examine the role that place-based prevention and place-focused medical care plays in the future health and well-being of U.S. residents.

      PubDate: 2018-04-11T12:41:08Z
      DOI: 10.1016/j.orcp.2018.02.005
  • Osteopontin-deficient progenitor cells display enhanced differentiation to
    • Authors: Veronica Moreno-Viedma; Matteo Tardelli; Maximilian Zeyda; Maria Sibilia; J. Deborah Burks; Thomas M. Stulnig
      Abstract: Publication date: Available online 6 March 2018
      Source:Obesity Research & Clinical Practice
      Author(s): Veronica Moreno-Viedma, Matteo Tardelli, Maximilian Zeyda, Maria Sibilia, J. Deborah Burks, Thomas M. Stulnig
      Objective Osteopontin (OPN, Spp1) is a protein upregulated in white adipose tissue (WAT) of obese subjects. Deletion of OPN protects mice from high-fat diet-induced WAT inflammation and insulin resistance. However, the alterations mediated by loss of OPN in WAT before the obesogenic challenge have not yet been investigated. Therefore, we hypothesised that the lack of OPN might enhance the pro-adipogenic micro environment before obesity driven inflammation. Methods OPN deficiency was tested in visceral (V) and subcutaneous (SC) WAT from WT and Spp1−/− female mice. Gene expression for hypoxia, inflammation and adipogenesis was checked in WT vs. Spp1−/− mice (n=15). Adipocytes progenitor cells (APC) were isolated by fluorescence cell sorting and role of OPN deficiency in adipogenesis was investigated by cell images and RT-PCR. Results We show that Spp1−/− maintained normal body and fat-pad weights, although hypoxia and inflammation markers were significantly reduced. In contrast, expression of genes involved in adipogenesis was increased in WAT from Spp1−/− mice. Strikingly, APC from Spp1−/− were diminished but differentiated more efficiently to adipocytes than those from control mice. Conclusions APC from SC-WAT of lean OPN-deficient mice display an enhanced capacity for differentiating to adipocytes. These alterations may explain the healthy expansion of WAT in the OPN-deficient model which is associated with reduced inflammation and insulin resistance.

      PubDate: 2018-04-11T12:41:08Z
      DOI: 10.1016/j.orcp.2018.02.006
  • Deep brain stimulation as a therapeutic option for obesity: A critical
    • Authors: Cécile Bétry; Stéphane Thobois; Martine Laville; Emmanuel Disse
      Abstract: Publication date: Available online 21 February 2018
      Source:Obesity Research & Clinical Practice
      Author(s): Cécile Bétry, Stéphane Thobois, Martine Laville, Emmanuel Disse
      Despite a better understanding of obesity pathophysiology, treating this disease remains a challenge. New therapeutic options are needed. Targeting the brain is a promising way, considering both the brain abnormalities in obesity and the effects of bariatric surgery on the gut-brain axis. Deep brain stimulation could be an alternative treatment for obesity since this safe and reversible neurosurgical procedure modulates neural circuits for therapeutic purposes. We aimed to provide a critical review of published clinical and preclinical studies in this field. Owing to the physiology of eating and brain alterations in people with obesity, two brain areas, namely the hypothalamus and the nucleus accumbens are putative targets. Preclinical studies with animal models of obesity showed that deep brain stimulation of hypothalamus or nucleus accumbens induces weight loss. The mechanisms of action remain to be fully elucidated. Preclinical data suggest that stimulation of nucleus accumbens reduces food intake, while stimulation of hypothalamus could increase resting energy expenditure. Clinical experience with deep brain stimulation for obesity remains limited to six patients with mixed results, but some clinical trials are ongoing. Thus, drawing clear conclusions about the effectiveness of this treatment is not yet possible, even if the results of preclinical studies are encouraging. Future clinical studies should examine its efficacy and safety, while preclinical studies could help understand its mechanisms of action. We hope that our review will provide ways to design further studies.

      PubDate: 2018-02-26T02:44:05Z
      DOI: 10.1016/j.orcp.2018.02.004
  • Conversion to laparoscopic sleeve gastrectomy after failure of
           laparoscopic gastric band: A systematic review of the literature and cost
    • Authors: Antonio Gangemi; Sarah Russel; Krupa Patel; Hazbar Khalaf; Mario Masrur; Chandra Hassan
      Abstract: Publication date: Available online 13 February 2018
      Source:Obesity Research & Clinical Practice
      Author(s): Antonio Gangemi, Sarah Russel, Krupa Patel, Hazbar Khalaf, Mario Masrur, Chandra Hassan
      No universal consensus has been achieved as to whether the laparoscopic adjustable gastric band to laparoscopic sleeve gastrectomy conversion should be performed in one or two steps. To determine the differences in operative outcomes and cost, a systematic, comprehensive review of the literature was conducted using the PubMed database from the National Institutes of Health. Nine studies were included with 809 patients. Weighted averages were calculated to compare operative outcomes, and cost analyses were conducted with these averages. Results indicate a longer operative time for the one-step approach than the two-step approach, but studies included in the meta-analysis found no statistical difference between the two. The two-step approach was found to have a longer length of hospital stay, but this finding refuted included studies that indicate no significant difference. Complication rates were higher for the one-step approach than the two-step approach, and costs associated with complications average $806 more for one-step patients than two-step patients. This suggests that the two-step approach could prove better for patient safety and cost outcomes, but both approaches are comparable in operating time and length of stay.

      PubDate: 2018-02-26T02:44:05Z
      DOI: 10.1016/j.orcp.2017.12.004
  • Abnormal of inter-hemispheric functional connectivity in elderly subjects
           with overweight/obesity
    • Authors: Xiao Luo; Kaicheng Li; YL Jia; Qingze Zeng; Yerfan Jiaerken; Tiantian Qiu; Peiyu Huang; Xiaojun Xu; Minming Zhang
      Abstract: Publication date: Available online 12 February 2018
      Source:Obesity Research & Clinical Practice
      Author(s): Xiao Luo, Kaicheng Li, YL Jia, Qingze Zeng, Yerfan Jiaerken, Tiantian Qiu, Peiyu Huang, Xiaojun Xu, Minming Zhang
      Background There is a growing literature documenting a variety of brain abnormalities associated with obesity. However, little is known about the effects of obesity on inter-hemispheric connectivity in aging people. Methods Participants included 61 cognitively intact elderly (including people with obesity, overweight, and lean controls) who underwent structural MRI, resting-state functional magnetic resonance imaging (rsfMRI) and standard neuropsychological batteries. Techniques including FreeSurfer and Voxel-mirrored Homotopic Connectivity (VMHC) were employed to evaluate inter-hemispheric structural and functional connectivity respectively. Results There were no differences of cognitive abilities and vascular risks among groups. When compared to lean controls, obese group had greater VMHC in fusiform gyrus (FG); while overweight group had greater VMHC in FG, calcarine gyrus, inferior temporal gyrus (ITG), and postcentral gyrus (PCG). Moreover, the obesity group had lower VMHC in calcarine gyrus and PCG than overweight group (p<0.05, corrected). Conclusions The present study suggested, increased inter-hemispheric information transmission in networks supporting visual and sensorimotor function may lead to gain in weight, by possibly mediating diet behaviours of individuals.

      PubDate: 2018-02-26T02:44:05Z
      DOI: 10.1016/j.orcp.2018.01.003
  • The engagement pathway: A conceptual framework of engagement-related terms
           in weight management
    • Authors: James D. Nobles; Arnaldo Perez; Joseph A. Skelton; Nicholas D. Spence; Geoff D. Ball
      Abstract: Publication date: Available online 12 February 2018
      Source:Obesity Research & Clinical Practice
      Author(s): James D. Nobles, Arnaldo Perez, Joseph A. Skelton, Nicholas D. Spence, Geoff D. Ball
      Engagement denotes the extent to which, and how, individuals participate in weight management (WM) services. Effective WM services should generate meaningful outcomes and promote high participant engagement; however, research is predominantly focused on the former. Given that engagement is a poorly understood phenomenon, and that engagement-related concepts are often used synonymously (e.g., dropout and attrition), the engagement pathway is hereby introduced. This pathway defines key concepts (e.g., recruitment, adherence, attrition) and their relationships in the enrolment, intervention, and maintenance stages of treatment. The pathway will help researchers and practitioners better understand engagement-related concepts whilst encouraging greater conceptual consistency between studies.

      PubDate: 2018-02-26T02:44:05Z
      DOI: 10.1016/j.orcp.2017.12.005
  • The mechanisms linking obesity to colon cancer: An overview
    • Authors: Aleksandra Tarasiuk; Paula Mosińska; Jakub Fichna
      Abstract: Publication date: Available online 7 February 2018
      Source:Obesity Research & Clinical Practice
      Author(s): Aleksandra Tarasiuk, Paula Mosińska, Jakub Fichna
      Obesity, characterised as a chronic low-grade inflammation is a crucial risk factor for colon cancer. The expansion of the adipose tissue is related to elevated triglyceride and low-density lipoprotein (LDL) levels and hyperinsulinemia, which all are presumed mediators of the tumour development. Obesity is also believed to support carcinogenesis by activating the insulin/IGF-1 pathway. Moreover, obesity increases the level of proinflammatory cytokines (e.g. TNF-α, IL-1, and IL-6) and has a significant impact on selected adipokines. This paper briefly outlines the latest evidence of the linkage between the obesity and colon cancer and discusses its possible implication for the improvement of anticancer prevention and treatment strategies connected with nutrition.

      PubDate: 2018-02-26T02:44:05Z
      DOI: 10.1016/j.orcp.2018.01.005
  • Is there a role for shared decision-making in pediatric weight
    • Authors: Maryam Kebbe; Arnaldo Perez; Geoff D.C. Ball
      Abstract: Publication date: Available online 1 February 2018
      Source:Obesity Research & Clinical Practice
      Author(s): Maryam Kebbe, Arnaldo Perez, Geoff D.C. Ball
      Shared decision-making (SDM) is central to personalising health and medical decisions. This decisional model encourages patients to act as managers of their own care while maintaining a partnership with health professionals. Although applied to some conditions, SDM has been used infrequently in pediatric weight management (PWM). Herein, we highlight the applicability and usefulness of SDM in making several important decisions related to PWM, including referral-making to different levels of care and treatment initiation and implementation. We conclude by describing possible challenges that may arise when implementing this model and suggest strategies to optimise the use of SDM in PWM.

      PubDate: 2018-02-05T06:05:13Z
      DOI: 10.1016/j.orcp.2018.01.004
  • Metabolically healthy obesity without fatty liver and risk of incident
           type 2 diabetes: A meta-analysis of prospective cohort studies
    • Authors: Yoshitaka Hashimoto; Masahide Hamaguchi; Muhei Tanaka; Akihiro Obora; Takao Kojima; Michiaki Fukui
      Abstract: Publication date: Available online 5 January 2018
      Source:Obesity Research & Clinical Practice
      Author(s): Yoshitaka Hashimoto, Masahide Hamaguchi, Muhei Tanaka, Akihiro Obora, Takao Kojima, Michiaki Fukui
      Objective A meta-analysis indicated that metabolically healthy obesity (MHO) presents a risk of incident type 2 diabetes, but it has not yet been established whether MHO without fatty liver (w/o FL) also presents a risk of incident diabetes. Methods We searched the MEDLINE and Embase databases to identify relevant prospective cohort studies and we supplemented the search with original data from the NAGALA (NAfld in Gifu Area, Longitudinal Analysis) study, defining MHO as a body mass index (BMI) ≥25 kg/m2 plus the presence of non or one of the following factors: hypertension, impaired fasting glucose, low high-density lipoprotein cholesterol, and hypertriglyceridemia. Using a random effects model, we calculated the pooled relative risks (RRs) and 95% confidence intervals (CIs) of incident diabetes. Results Our meta-analysis included three studies from the databases plus the NAGALA study, with a total of 134,667 subjects, including 8675 MHO subjects w/o FL and 7218 MHO subjects with fatty liver (wFL). Compared to the metabolically healthy non-overweight subjects w/o FL, the RRs of incident diabetes in the MHO w/o FL and MHO wFL groups were 1.42 (95%CI 1.11–1.77) and 3.28 (95%CI 2.30–4.67). Conclusions Our meta-analysis results demonstrate that the MHO phenotype, with or without fatty liver, presents a risk of the development of type 2 diabetes. Individuals with MHO who do not have fatty liver should be monitored carefully — similarly to those with fatty liver — for the development of diabetes.

      PubDate: 2018-02-05T06:05:13Z
      DOI: 10.1016/j.orcp.2017.12.003
  • Development and validation of a Weight-Specific Health Literacy Instrument
    • Authors: Tzu-I Tsai; Shoou-Yih D. Lee
      Abstract: Publication date: Available online 18 December 2017
      Source:Obesity Research & Clinical Practice
      Author(s): Tzu-I Tsai, Shoou-Yih D. Lee
      Objective Develop/validate a weight-specific health literacy instrument. Methods The development of weight-specific health literacy measurement consisted of seven phases: (a) a literature review; (b) consultation with weight management experts; (c) generation of an item pool; (d) selection of items via the Delphi method; (e) pilot testing; (f) a national survey; and (g) examination of the psychometric properties of the results. Results A random sample of 362 Taiwanese adults completed the face-toface survey. The results of factor analysis indicated reasonable good fit of a 2-factor model (χ 2/df=1.1, p=0.18; RMSEA=0.02, CFI=0.99, TLI=0.99). Construct validity testing showed that the both factors were significantly correlated with s-MHLS (γ =0.71, p<0.001; γ =0.22, p<0.001), comprehension (γ =0.32, p<0.001: γ =0.10, p<0.05), and writing (γ =0.44, p<0.001: γ =0.11, p<0.05). Predictive validity testing showed that the first factor had significant correlations with weight management efficacy (γ =0.16, p<0.001), and three weight management behaviors. The second factor was significantly correlated with weight management efficacy (γ =0.11, p<0.05) but not with the 3 weight management behaviors. Conclusions On the basis of the psychometric results, we conclude that the final version of Weight-Specific Health Literacy Instrument (WSHLI) includes the 13 items. It is a valid and reliable tool for weight management research and evaluation in Mandarin Chinese speaking populations.

      PubDate: 2017-12-26T15:40:33Z
      DOI: 10.1016/j.orcp.2017.11.003
  • Reduced gene expression of sirtuins and active AMPK levels in children and
           adolescents with obesity and insulin resistance
    • Authors: Zahra Arab Sadeghabadi; Mitra Nourbakhsh; Parvin Pasalar; Solaleh Emamgholipour; Abolfazl Golestani; Bagher Larijani; Maryam Razzaghy-Azar
      Abstract: Publication date: Available online 14 November 2017
      Source:Obesity Research & Clinical Practice
      Author(s): Zahra Arab Sadeghabadi, Mitra Nourbakhsh, Parvin Pasalar, Solaleh Emamgholipour, Abolfazl Golestani, Bagher Larijani, Maryam Razzaghy-Azar
      Background Sirtuins, including SIRT1 and SIRT2, are longevity-associated deacetylase enzymes that modulate metabolic homeostasis in response to the cellular energy state. Adenosine monophosphate activated protein kinase (AMPK) and SIRT1 are interrelated and share several common target pathways. This study aimed to evaluate the SIRT1 and SIRT2 gene expression in peripheral blood mononuclear cells (PBMCs) as well as plasma levels of AMPK, in obese children and adolescents. Materials and methods Participants included 60 children and adolescents (30 obese and 30 age- and gender-matched control subjects). Real-time polymerase chain reaction (PCR) was used to assess the SIRT1 and SIRT2 gene expression in PBMCs. Serum phospho-AMPK and insulin were measured using enzyme-linked immunosorbent assay (ELISA), and insulin resistance (IR) was calculated by the Homeostasis Model of Assessment of Insulin Resistance (HOMA-IR). Glucose and lipid profile were also measured. Results SIRT1 gene expression and phospho-AMPK plasma levels were significantly diminished in obese subjects compared to the control group, and both SIRT1 and SIRT2 were significantly lower in obese children with IR compared to those without IR. SIRT1 expression revealed significant negative correlations with body mass index and waist circumference as well as insulin and HOMA-IR and a positive correlation with AMPK. SIRT2 negatively correlated with SIRT1 and positively correlated with high density lipoprotein-cholesterol (HDL-C). Conclusion SIRT1 and SIRT2 expression and AMPK levels decrease in children with obesity and IR. Targeting SIRT1 can be valuable in preventing obesity-associated IR in childhood and adolescence.

      PubDate: 2017-11-17T05:20:10Z
      DOI: 10.1016/j.orcp.2017.10.004
  • Association between obesity and self-reported sleep duration variability,
           sleep timing, and age in the Japanese population
    • Authors: Nobuo Sasaki; Saeko Fujiwara; Hidehisa Yamashita; Ryoji Ozono; Yuko Monzen; Kazushi Teramen; Yasuki Kihara
      Abstract: Publication date: Available online 8 November 2017
      Source:Obesity Research & Clinical Practice
      Author(s): Nobuo Sasaki, Saeko Fujiwara, Hidehisa Yamashita, Ryoji Ozono, Yuko Monzen, Kazushi Teramen, Yasuki Kihara
      Objective The objective of this study was to investigate the association between obesity and sleep habits, including bedtime, wake-up time, and sleep duration variability over a week. Methods We analyzed 9289 participants in this study. Following a health examination, each participant self-reported their sleep habits using a standardized 19-item questionnaire. High sleep duration variability was defined as sleep varying ≥3h of the difference between the longest and shortest sleep durations reported over a week-long period. Late bedtime and early wake-up time were defined as 24:00h or later, and before 6:00h, respectively. Obesity was defined as a body mass index (BMI) of ≥25kg/m2. Subgroup analysis included age (younger group defined as age <65 years vs. elderly group defined as age ≥65 years). Results After adjusting for confounding factors and sleep duration, high sleep duration variability [odds ratio (OR), 1.20; p< 0.005] was significantly associated with a high OR of obesity. Late bedtime (OR, 1.18; p< 0.01) was significantly associated with a high OR of obesity, whereas early wake-up was not. In the subgroup analysis, high sleep duration variability had a significant association with the younger group (OR, 1.25; p <0.001), whereas late bedtime had a significant association with the elderly group (OR, 1.36; p <0.005). Conclusions Inappropriate sleep habits, particularly high sleep duration variability in young individuals and late bedtime in the elderly, are associated with a high prevalence of obesity, independently of sleep duration.

      PubDate: 2017-11-10T04:14:00Z
      DOI: 10.1016/j.orcp.2017.10.008
  • Myeloid ATG16L1 does not affect adipose tissue inflammation or body mass
           in mice fed high fat diet
    • Authors: Evelyn M.S. Litwinoff; Merav Y. Gold; Karan Singh; Jiyuan Hu; Huilin Li; Ken Cadwell; Ann Marie Schmidt
      Abstract: Publication date: Available online 2 November 2017
      Source:Obesity Research & Clinical Practice
      Author(s): Evelyn M.S. Litwinoff, Merav Y. Gold, Karan Singh, Jiyuan Hu, Huilin Li, Ken Cadwell, Ann Marie Schmidt
      Background An influx of lipid-loaded macrophages characterizes visceral adipose tissue (VAT) inflammation, which is an important factor in the development of insulin resistance (IR) in obesity. Depletion of macrophage lipids accompanies increased whole body insulin sensitivity, but the underlying mechanism is unknown. Deficiency of autophagy protein ATG16L1 is associated with increases in inflammatory diseases and lipid metabolism, but the connection between ATG16L1, IR, and obesity remains elusive. We hypothesize that myeloid ATG16L1 contributes to lipid loading in macrophages and to IR. Methods Wild-type (WT) bone marrow derived macrophages (BMDMs) were treated with fatty acids and assessed for markers of autophagy. Myeloid-deficient Atg16l1 and littermate control male mice were fed high fat diet (HFD) or low fat diet (LFD) for 3 months starting at 8 weeks of age. Mice were assessed for body mass, fat and lean mass, glucose and insulin sensitivity, food consumption and adipose inflammation. Fluorescence-activated cell sorted VAT macrophages were assessed for lipid content and expression of autophagy related genes. Results VAT and VAT macrophages from HFD-fed WT mice did not show differences in autophagy protein and gene expression compared to tissue from LFD-fed mice. Fatty acid-treated BMDMs increased neutral lipid content but did not change autophagy protein expression. HFD-fed Atg16l1 myeloid-deficient and littermate mice demonstrated no differences in body mass, glucose or insulin sensitivity, food consumption, fat or lean mass, macrophage lipid content, or adipose tissue inflammation. Conclusion ATG16L1 does not contribute to obesity, IR, adipose tissue inflammation or lipid loading in macrophages in mice fed HFD.

      PubDate: 2017-11-10T04:14:00Z
      DOI: 10.1016/j.orcp.2017.10.006
  • Dynamic status of metabolically healthy overweight/obesity and
           metabolically unhealthy and normal weight and the risk of type 2 diabetes
           mellitus: A cohort study of a rural adult Chinese population
    • Authors: Bingyuan Wang; Ming Zhang; Shu Wang; Chongjian Wang; Jinjin Wang; Linlin Li; Lu Zhang; Yongcheng Ren; Chengyi Han; Yang Zhao; Junmei Zhou; Guo’an Wang; Yanxia Shen; Dongting Wu; Chao Pang; Lei Yin; Tianping Feng; Jingzhi Zhao; Xinping Luo; Dongsheng Hu
      Abstract: Publication date: Available online 31 October 2017
      Source:Obesity Research & Clinical Practice
      Author(s): Bingyuan Wang, Ming Zhang, Shu Wang, Chongjian Wang, Jinjin Wang, Linlin Li, Lu Zhang, Yongcheng Ren, Chengyi Han, Yang Zhao, Junmei Zhou, Guo’an Wang, Yanxia Shen, Dongting Wu, Chao Pang, Lei Yin, Tianping Feng, Jingzhi Zhao, Xinping Luo, Dongsheng Hu
      Objective We aimed to determine dynamic status of metabolically healthy overweight or obesity (MHO) and metabolically unhealthy and normal weight (MUNW) and the risk of incident type 2 diabetes mellitus (T2DM). Methods Body mass index and metabolic health were assessed on 11,865 eligible participants ≥18 years from 6-year follow-up cohort study of a rural Chinese population. Participants were classified as metabolically healthy and normal weight (MHNW), MHO, MUNW and metabolically unhealthy overweight or obesity (MUO) at both baseline and follow-up examinations. Hazard ratio (HR) and 95% confidence interval (CI) were used to assess baseline and their changes of BMI-metabolic status and the risk of incident T2DM. Results Risk of T2DM was increased for all participants with baseline MHO, MUNW, and MUO (adjusted HR 1.94, 95% CI 1.33–2.81; 3.10, 95% CI 2.19–4.39; and 6.63, 95% CI 4.94–8.90, all P< 0.001, respectively). However, risk of T2DM was increased for participants with transformation from MHO to MUO (4.52, 95% CI 2.42–8.47, P< 0.001) as compared with stable MHNW, but not stable MHO (0.53, 95CI 0.20–1.40, P =0.20). Risk of T2DM did not differ between participants with transformation from MUNW to metabolically healthy and those with stable MHNW (P> 0.05), but was increased with stable MUNW (5.78, 95% CI 3.15–10.62, P <0.001). The results were consistent when analyses were restricted to participants without baseline impaired fasting glucose level. Conclusions Our findings provide understanding for differentiating high-risk individuals for incident T2DM in Chinese population.

      PubDate: 2017-11-10T04:14:00Z
      DOI: 10.1016/j.orcp.2017.10.005
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Heriot-Watt University
Edinburgh, EH14 4AS, UK
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