for Journals by Title or ISSN
for Articles by Keywords
help
  Subjects -> HISTORY (Total: 1089 journals)
    - HISTORY (736 journals)
    - History (General) (46 journals)
    - HISTORY OF AFRICA (41 journals)
    - HISTORY OF ASIA (35 journals)
    - HISTORY OF AUSTRALASIA AND OTHER AREAS (8 journals)
    - HISTORY OF EUROPE (117 journals)
    - HISTORY OF THE AMERICAS (91 journals)
    - HISTORY OF THE NEAR EAST (15 journals)

HISTORY (736 journals)            First | 1 2 3 4 5 6 7 8 | Last

Historiæ     Open Access   (Followers: 1)
History & Memory     Full-text available via subscription   (Followers: 24)
History Australia     Full-text available via subscription   (Followers: 5)
History Compass     Hybrid Journal   (Followers: 9)
History in Africa     Full-text available via subscription   (Followers: 6)
History of CERN     Full-text available via subscription   (Followers: 1)
History of Education Quarterly     Hybrid Journal   (Followers: 4)
History of Education Review     Hybrid Journal   (Followers: 3)
History of Education: Journal of the History of Education Society     Hybrid Journal   (Followers: 14)
History of European Ideas     Hybrid Journal   (Followers: 18)
History of Political Thought     Full-text available via subscription   (Followers: 15)
History of Psychology     Full-text available via subscription   (Followers: 5)
History of Religions     Full-text available via subscription   (Followers: 25)
History of Science     Full-text available via subscription   (Followers: 13)
History Today     Full-text available via subscription   (Followers: 1)
Holocaust and Genocide Studies     Hybrid Journal   (Followers: 16)
Hortus Artium Medievalium     Full-text available via subscription   (Followers: 4)
HSE - Social and Education History     Open Access  
IEEE Annals of the History of Computing     Full-text available via subscription   (Followers: 9)
IKON     Full-text available via subscription   (Followers: 4)
Il Capitale Culturale. Studies on the Value of Cultural Heritage     Open Access   (Followers: 3)
ILCEA     Open Access   (Followers: 1)
Illawarra Unity - Journal of the Illawarra Branch of the Australian Society for the Study of Labour History     Open Access   (Followers: 2)
Images re-vues : histoire, anthropologie et théorie de l'art     Open Access   (Followers: 1)
Imago Mundi: The International Journal for the History of Cartography     Hybrid Journal   (Followers: 7)
Immigrants & Minorities     Hybrid Journal   (Followers: 9)
Indian Economic & Social History Review     Hybrid Journal   (Followers: 4)
Indonesia and the Malay World     Hybrid Journal   (Followers: 3)
Inner Asia     Hybrid Journal   (Followers: 2)
Intellectual History Review     Hybrid Journal   (Followers: 16)
Interaction     Full-text available via subscription   (Followers: 2)
Intermédialités : histoire et théorie des arts, des lettres et des techniques / Intermedialities: History and Theory of the Arts, Literature and Techniques     Full-text available via subscription   (Followers: 3)
International Journal of Asian Studies     Hybrid Journal   (Followers: 9)
International Journal of Iberian Studies     Hybrid Journal   (Followers: 4)
International Journal of Middle East Studies     Hybrid Journal   (Followers: 180)
International Journal of Society Systems Science     Hybrid Journal  
International Journal of Sustainable Society     Hybrid Journal   (Followers: 7)
International Politics     Partially Free   (Followers: 16)
International Review of Social History     Full-text available via subscription   (Followers: 17)
INTRECCI d'arte     Open Access   (Followers: 6)
Iran and the Caucasus     Hybrid Journal   (Followers: 6)
Irish Studies Review     Hybrid Journal   (Followers: 13)
Isis     Full-text available via subscription   (Followers: 11)
Israel Studies Forum     Full-text available via subscription  
Itinerari di ricerca storica     Open Access  
Japanese Studies     Hybrid Journal   (Followers: 4)
Jewish Culture and History     Hybrid Journal   (Followers: 8)
Journal Asiatique     Full-text available via subscription   (Followers: 3)
Journal for Contemporary History     Full-text available via subscription   (Followers: 12)
Journal for Early Modern Cultural Studies     Full-text available via subscription   (Followers: 13)
Journal for Maritime Research     Hybrid Journal   (Followers: 7)
Journal for the Study of Judaism     Hybrid Journal   (Followers: 8)
Journal for the Study of Radicalism     Full-text available via subscription   (Followers: 5)
Journal of Aging, Humanities, and the Arts: Official Journal of the Gerontological Society of America     Hybrid Journal   (Followers: 4)
Journal of American History     Hybrid Journal   (Followers: 23)
Journal of American Studies     Hybrid Journal   (Followers: 13)
Journal of American-East Asian Relations     Hybrid Journal  
Journal of Ancient History and Archaeology     Open Access  
Journal of Arts Management, Law, and Society     Full-text available via subscription   (Followers: 7)
Journal of Australian Colonial History     Full-text available via subscription   (Followers: 6)
Journal of Australian Naval History, The     Full-text available via subscription   (Followers: 4)
Journal of Baltic Studies     Hybrid Journal   (Followers: 3)
Journal of British Studies     Full-text available via subscription   (Followers: 24)
Journal of Canadian Studies/Revue d'études canadiennes     Full-text available via subscription   (Followers: 2)
Journal of Cognitive Historiography     Full-text available via subscription  
Journal of Colonialism and Colonial History     Full-text available via subscription   (Followers: 9)
Journal of Conflict Studies     Full-text available via subscription   (Followers: 12)
Journal of Contemporary Asia     Hybrid Journal   (Followers: 2)
Journal of Contemporary China     Hybrid Journal   (Followers: 7)
Journal of Contemporary History     Hybrid Journal   (Followers: 18)
Journal of Coptic Studies     Full-text available via subscription   (Followers: 4)
Journal of Cuneiform Studies     Full-text available via subscription   (Followers: 5)
Journal of Early Modern History     Hybrid Journal   (Followers: 22)
Journal of East Asian Linguistics     Hybrid Journal   (Followers: 4)
Journal of Ecclesiastical History     Hybrid Journal   (Followers: 18)
Journal of English and Germanic Philology (JEGP)     Full-text available via subscription   (Followers: 7)
Journal of European Studies     Hybrid Journal   (Followers: 18)
Journal of Family History     Hybrid Journal   (Followers: 16)
Journal of Global History     Full-text available via subscription   (Followers: 14)
Journal of Historical Geography     Hybrid Journal   (Followers: 16)
Journal of Historical Pragmatics     Full-text available via subscription   (Followers: 2)
Journal of Historical Research in Marketing     Hybrid Journal   (Followers: 3)
Journal of Iberian and Latin American Studies     Hybrid Journal   (Followers: 12)
Journal of Imperial and Commonwealth History     Hybrid Journal   (Followers: 11)
Journal of Indian Society of Pedodontics and Preventive Dentistry     Open Access   (Followers: 1)
Journal of Israeli History: Politics, Society, Culture     Hybrid Journal   (Followers: 6)
Journal of Jewish Identities     Full-text available via subscription   (Followers: 8)
Journal of Latin American Cultural Studies: Travesia     Hybrid Journal   (Followers: 10)
Journal of Latin American Studies     Hybrid Journal   (Followers: 14)
Journal of Legal History     Hybrid Journal   (Followers: 14)
Journal of Medieval History     Hybrid Journal   (Followers: 200)
Journal of Medieval Iberian Studies     Hybrid Journal   (Followers: 6)
Journal of Medieval Religious Cultures     Full-text available via subscription   (Followers: 12)
Journal of Military History     Full-text available via subscription   (Followers: 17)
Journal of Modern Chinese History     Hybrid Journal   (Followers: 5)
Journal of Modern Greek Studies     Full-text available via subscription   (Followers: 2)
Journal of Modern History, The     Full-text available via subscription   (Followers: 194)
Journal of Modern Italian Studies     Hybrid Journal   (Followers: 4)
Journal of Modern Russian History and Historiography     Hybrid Journal   (Followers: 8)
Journal of Moravian History     Full-text available via subscription   (Followers: 3)

  First | 1 2 3 4 5 6 7 8 | Last

Journal Cover Journal of the American Society of Hypertension
   [6 followers]  Follow    
   Hybrid Journal Hybrid journal (It can contain Open Access articles)
     ISSN (Print) 1933-1711
     Published by Elsevier Homepage  [2575 journals]   [SJR: 0.803]   [H-I: 17]
  • Treatment Special Conditions: Resistant Hypertension
    • Abstract: Publication date: Available online 16 December 2014
      Source:Journal of the American Society of Hypertension
      Author(s): Henry R. Black



      PubDate: 2014-12-18T08:13:00Z
       
  • Treatment Special Conditions: Assessing Blood Pressure in Children
           & Adolescents
    • Abstract: Publication date: Available online 15 December 2014
      Source:Journal of the American Society of Hypertension
      Author(s): Donald L. Batisky



      PubDate: 2014-12-18T08:13:00Z
       
  • A Content Analysis of Smartphone-Based Applications for Hypertension
           Management
    • Abstract: Publication date: Available online 11 December 2014
      Source:Journal of the American Society of Hypertension
      Author(s): Nilay Kumar , Monica Khunger , Arjun Gupta , Neetika Garg
      Introduction Smartphone-based medical applications (apps) can facilitate self-management of hypertension (HTN). The content and consumer interaction metrics of HTN-related apps are unknown. Methods In this cross-sectional study to ascertain the content of medical apps designed for HTN management, we queried Google Play and Apple iTunes using the search terms “hypertension” and “high blood pressure”. Top 107 apps were analyzed. Major app functionalities including tracking (for BP, pulse, weight, BMI), medical device (to measure pulse or BP), general information on HTN and medication adherence tools was recorded along with consumer engagement parameters. Data were collected from May 28 to May 30, 2014. Results 72% of the apps had tracking function, 22% had tools to enhance medication adherence, 37% contained general information on HTN and 8% contained information on DASH diet. These data showed that a majority of apps for HTN are designed primarily for health management functions. However, 14% of Google Android apps could transform the smartphone into a medical device to measure BP. None of these apps employed the use of a BP cuff or had any documentation of validation against a gold standard. Only 3% of the apps were developed by healthcare agencies such as universities or professional organizations. In regression models the medical device function was highly predictive of greater number of downloads (OR 97.08, p<0.001) and positive consumer reviews (IRR 1204.39, p<0.001). Conclusion A large majority of medical apps designed for HTN serve health management functions such as tracking blood pressure, weight or BMI. Consumers have a strong tendency to download and favorably rate apps that are advertised to measure blood pressure and heart rate, despite a lack of validation for these apps. There is a need for greater oversight in medical app development for HTN, especially when they qualify as a medical device.


      PubDate: 2014-12-14T10:49:52Z
       
  • Is the Failure of SYMPLICITY HTN-3 trial to Meet its Efficacy Endpoint the
           “End of the Road” for Renal Denervation?
    • Abstract: Publication date: Available online 11 December 2014
      Source:Journal of the American Society of Hypertension
      Author(s): Murray Epstein , Eduardo de Marchena
      Resistant hypertension is a common medical problem which is increasing with the advent of an increasingly older and heavier population. The etiology of resistant hypertension is almost always multifactorial, but the results of numerous studies indicate that renal sympathetic activation is a particularly common cause of resistance to antihypertensive treatment. Consistent with the belief in a pivotal role of renal sympathetic stimulation, there has been a growing interest in renal denervation (RDN) treatment strategies. The long-awaited results of SYMPLICITY HTN-3 study disclosed that the reduction in blood pressure by the SYMPLICITY device did not differ from (that) in the sham- procedure arm of the study. In the present article we identify several factors that explain why the study failed to demonstrate any benefit from the intervention. The reasons are multifactorial and include inadequate screening at entry and frequent medication changes during the study. Additional problems include the lack of experience of many operators with the SYMPLICITY device and procedure variability, as attested to by a diminished number of ablation “quadrants”. Also, the inability of the 1st generation Medtronic device to allow four ablations to be performed simultaneously. We recommend that future RDN studies adhere to more rigorous screening procedures, and utilize newer multi-site denervation systems that facilitate four ablations simultaneously. Drug optimization should be achieved by monitoring adherence throughout the study. Nevertheless, we are optimistic about a future role of RDN. To optimize chances of success, increased efforts are necessary to identify the appropriate patients for RDN and investigators must use second and third generation denervation devices and techniques.


      PubDate: 2014-12-14T10:49:52Z
       
  • Cornell product relates to albuminuria in hypertensive black adults
           independently of blood pressure: the SABPA study
    • Abstract: Publication date: Available online 11 December 2014
      Source:Journal of the American Society of Hypertension
      Author(s): Rudolph Schutte , Hugo W. Huisman , lisa J. Ware , Catherina MC. Mels , Wayne Smith , Nicolaas T. Malan , Leoné Malan , Johannes M. van Rooyen , Carla MT. Fourie , Aletta E. Schutte
      Background Evidence of the relationship between left ventricular hypertrophy and urinary albumin excretion is contradictory and limited in black adults in whom hypertensive heart disease is common. We aimed to investigate the relationship between subclinical left ventricular hypertrophy and albuminuria in non-diabetic hypertensive blacks. Methods Urinary albumin-to-creatinine ratio (UACR) was determined from 8h overnight urine collection. We recorded ambulatory blood pressure and 12-lead electrocardiogram during a typical working day. Results Cornell product (P=0.002), UACR (P=0.042), 24h systolic pressure (P<0.0001) and 24h pulse pressure (P<0.0001) were higher in the hypertensive group. Cornell product was associated with UACR in single (r=0.25,P=0.012), partial (P trend=0.002) and multiple regression (β=0.326,P=0.0005) analyses in the hypertensive group only, even below the threshold for microalbuminuria and independent of 24h systolic pressure. Conclusion Urinary albumin excretion is associated with subclinical left ventricular hypertrophy in non-diabetic hypertensive blacks and may be a useful marker of early cardiovascular disease in blacks.


      PubDate: 2014-12-14T10:49:52Z
       
  • Amiloride lowers blood pressure and attenuates urine plasminogen
           activation in patients with treatment–resistant hypertension
    • Abstract: Publication date: December 2014
      Source:Journal of the American Society of Hypertension, Volume 8, Issue 12
      Author(s): Christina S. Oxlund , Kristian B. Buhl , Ib A. Jacobsen , Mie R. Hansen , Jeppe Gram , Jan Erik Henriksen , Karoline Schousboe , Lise Tarnow , Boye L. Jensen
      In conditions with albuminuria, plasminogen is aberrantly filtered across the glomerular barrier and activated along the tubular system to plasmin. In the collecting duct, plasmin activates epithelial sodium channels (ENaC) proteolytically. Hyperactivity of ENaC could link microalbuminuria/proteinuria to resistant hypertension. Amiloride, an ENaC inhibitor, inhibits urokinase–type plasminogen activator. We hypothesized that amiloride (1) reduces blood pressure (BP); (2) attenuates plasminogen–to–plasmin activation; and (3) inhibits urine urokinase–type plasminogen activator in patients with resistant hypertension and type 2 diabetes mellitus (T2DM).In an open–label, non–randomized, 8–week intervention study, a cohort (n = 80) of patients with resistant hypertension and T2DM were included. Amiloride (5 mg/d) was added to previous triple antihypertensive treatment (including a diuretic and an inhibitor of the renin–angiotensin–aldosterone system) and increased to 10 mg if BP control was not achieved at 4 weeks. Complete dataset for urine analysis was available in 60 patients. Systolic and diastolic BP measured by ambulatory BP monitoring and office monitoring were significantly reduced. Average daytime BP was reduced by 6.3/3.0 mm Hg. Seven of 80 cases (9%) discontinued amiloride due to hyperkalemia >5.5 mol/L, the most frequent adverse event. Urinary plasmin(ogen) and albumin excretions were significantly reduced after amiloride treatment (P < .0001). Urokinase activity was detectable in macroalbuminuric urine, with a tendency toward reduction in activity after amiloride treatment. Amiloride lowers BP, urine plasminogen excretion and activation, and albumin/creatinine ratio, and is a relevant add–on medication for the treatment of resistant hypertension in patients with T2DM and microalbuminuria.


      PubDate: 2014-12-10T10:41:33Z
       
  • Gender differences in antihypertensive drug treatment: results from the
           Swedish Primary Care Cardiovascular Database (SPCCD)
    • Abstract: Publication date: December 2014
      Source:Journal of the American Society of Hypertension, Volume 8, Issue 12
      Author(s): Charlotta Ljungman , Thomas Kahan , Linus Schiöler , Per Hjerpe , Jan Hasselström , Björn Wettermark , Kristina Bengtsson Boström , Karin Manhem
      There are gender differences in antihypertensive treatment. This study aimed to investigate if gender differences in treatment could be explained by comorbidities. In addition, we aimed to study whether blood pressure control is different in women and men, and whether women interrupt treatment more often with angiotensin–converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) compared with men.This cohort study within the Swedish Primary Care Cardiovascular Database included 40,825 patients with hypertension attending primary health care from 2007 to 2008. Cardiovascular comorbidities, with the exception of heart failure, were more common in men. Women were more often treated with diuretics, and men with ACEI, as were hypertensive patients with diabetes. Comorbidities could not entirely explain gender differences in antihypertensive treatment in a regression model. Women had higher systolic and lower diastolic blood pressure; this was also true in subgroups with cardiovascular comorbidity. Men more often than women were prescribed ACEIs/ARBs and interrupted treatment. Women and men are treated with different antihypertensive drugs, and this is not fully explained by differences in comorbidities. Women have higher systolic blood pressures, irrespective of comorbidity. Men have interrupted treatment more often with ACEIs/ARBs. These gender differences could affect outcome and warrant further investigation.


      PubDate: 2014-12-10T10:41:33Z
       
  • Diagnostic evaluation Ambulatory blood pressure monitoring in clinical
           hypertension management
    • Abstract: Publication date: December 2014
      Source:Journal of the American Society of Hypertension, Volume 8, Issue 12




      PubDate: 2014-12-10T10:41:33Z
       
  • Thanks to Our Reviewers
    • Abstract: Publication date: December 2014
      Source:Journal of the American Society of Hypertension, Volume 8, Issue 12




      PubDate: 2014-12-10T10:41:33Z
       
  • Oscillometric blood pressure: a review for clinicians
    • Abstract: Publication date: December 2014
      Source:Journal of the American Society of Hypertension, Volume 8, Issue 12
      Author(s): Bruce S. Alpert , David Quinn , David Gallick
      Oscillometric devices for the non–invasive estimation of blood pressure (BP) have become the “clinical standard” because of training requirements for determination of BP by auscultation, cost, and the phasing–out/banning of mercury in many states and countries. Analysis of recent publications reveals a lack of understanding of the “meaning” of oscillometric blood pressure (OBP) measurements by authors, journal editors, and clinicians. We were invited to submit a review of OBP methodology written for clinicians. We hope that the material contained herein will clarify how clinicians should interpret OBP values for their patients.


      PubDate: 2014-12-10T10:41:33Z
       
  • Tick–tock–tick–tock: the impact of circadian rhythm
           disorders on cardiovascular health and wellness
    • Abstract: Publication date: December 2014
      Source:Journal of the American Society of Hypertension, Volume 8, Issue 12
      Author(s): Charlene E. Gamaldo , Youjin Chung , Yu Min Kang , Rachel Marie E. Salas
      Humans spend a third of their lives asleep. A well–balanced synchrony between sleep and wakefulness is needed to maintain a healthy lifestyle. Optimal sleep is based on an individual's inherent sleep requirement and circadian rhythm. If either one or both of these critical elements are disrupted, daytime dysfunction, non–restorative sleep, and/or reduced sense of well-being may result. While the medical community is more familiar with sleep disorders such as sleep apnea, insomnia, and narcolepsy, circadian rhythm sleep wake disorders (CRSWDs) are less known, despite these being common within the general population. CRSWDs are comprised of the following: shiftwork disorder, delayed sleep phase disorder, advanced sleep phase disorder, jet lag disorder, non–24–hour sleep–wake disorder, and irregular sleep–wake rhythm disorder. In general, a CRSWD results when there is misalignment between the sleep pattern and the desired sleep schedule, dictated by work, family, and social schedules. Subsequently, patients have difficulty falling asleep, maintaining sleep, and/or experience poor quality sleep predisposing them to insomnia or excessive sleepiness. In this article, we review the core concepts related to sleep, and sleep deprivation in the context of CRSWDs.


      PubDate: 2014-12-10T10:41:33Z
       
  • Long-term safety of nebivolol and valsartan combination therapy in
           patients with hypertension: an open-label, single-arm, multicenter study
    • Abstract: Publication date: December 2014
      Source:Journal of the American Society of Hypertension, Volume 8, Issue 12
      Author(s): Joel M. Neutel , Thomas D. Giles , Henry Punzi , Robert J. Weiss , Huiling Li , Amy Finck
      Long–term safety of a free–tablet combination of nebivolol and valsartan was assessed in a Phase III, open–label trial (NCT01415505). Adults with hypertension entered a 4–week placebo run–in phase, followed by a 52–week treatment phase. Initial dosage (Neb/Val 5/160 mg/d) was titrated up to 20/320 mg/d to achieve blood pressure (BP) goal (JNC7 criteria), with the addition of hydrochlorothiazide (up to 25 mg/d) if needed. Safety and tolerability parameters included adverse events. Efficacy assessments included baseline–to–endpoint change in diastolic BP and systolic BP and the percentage of patients who achieved BP goal. All analyses were performed using descriptive statistics. Study completion rate was 60.4% (489/810). The most frequent reason for discontinuation was insufficient therapeutic response (8.4%). Adverse events were experienced by 59.2% of patients, with the most common being headache (5.7%), nasopharyngitis (5.0%), and upper respiratory tract infection (4.6%). Three (0.4%) deaths occurred during the study; none was considered related to study medication. Mean ± standard deviation changes from baseline at week 52 (observed cases) were −25.5 ± 15.9 mm Hg (systolic BP) and −19.0 ± 8.7 mm Hg (diastolic BP). A total of 75.7% nebivolol/valsartan–treated and 57.8% nebivolol/valsartan/hydrochlorothiazide–treated completers achieved BP goal. Long–term treatment with nebivolol and valsartan in adults with hypertension was safe and well–tolerated.


      PubDate: 2014-12-10T10:41:33Z
       
  • The use of ambulatory blood pressure monitoring among Medicare
           beneficiaries in 2007–2010
    • Abstract: Publication date: December 2014
      Source:Journal of the American Society of Hypertension, Volume 8, Issue 12
      Author(s): Daichi Shimbo , Shia T. Kent , Keith M. Diaz , Lei Huang , Anthony J. Viera , Meredith Kilgore , Suzanne Oparil , Paul Muntner
      The US Centers for Medicaid and Medicare Services reimburses ambulatory blood pressure monitoring (ABPM) for suspected white coat hypertension. We estimated ABPM use between 2007 and 2010 among a 5% random sample of Medicare beneficiaries (≥65 years). In 2007, 2008, 2009, and 2010, the percentage of beneficiaries with ABPM claims was 0.10%, 0.11%, 0.10%, and 0.09%, respectively. A prior diagnosis of hypertension was more common among those with versus without an ABPM claim (77.7% vs. 47.0%). Among hypertensive beneficiaries, 95.2% of those with an ABPM claim were taking antihypertensive medication. Age 75–84 versus 65–74 years, having coronary heart disease, having chronic kidney disease, having multiple prior hypertension diagnoses, and having filled multiple classes of antihypertensive medication were associated with an increased odds for an ABPM claim among hypertensive beneficiaries. ABPM use was very low among Medicare beneficiaries and was not primarily used for diagnosing white coat hypertension in untreated individuals.


      PubDate: 2014-12-10T10:41:33Z
       
  • Salt intake, knowledge of salt intake, and blood pressure control in
           Chinese hypertensive patients
    • Abstract: Publication date: December 2014
      Source:Journal of the American Society of Hypertension, Volume 8, Issue 12
      Author(s): Yu Qin , Ting Li , Peian Lou , Guiqiu Chang , Pan Zhang , Peipei Chen , Cheng Qiao , Zongmei Dong
      A cross–sectional study involving 2502 subjects was conducted to evaluate salt intake, knowledge of salt intake, and blood pressure control in hypertensive patients. The blood pressure control rate was 33.5% among the hypertensive patients. Of the patients, 69.9% had salt intake higher than 6 g/d. Overall 35.0% knew the recommended salt intake, and 94.9% knew that “excess salt intake can result in hypertension.” Altogether, 85.8% of patients had received health education related to a low–salt diet at some time. Patients who consumed less than 6 g/d of salt had a higher control rate than those who consumed more than 6 g/d (48.7% vs. 27.0%; χ2 = 111.0; P < .001). Patients with knowledge of the recommended salt intake had a higher control rate than those without (45.8% vs. 26.9%; χ2 = 91.3; P < .001). Our findings suggest a high salt intake and low blood pressure control rate among Chinese hypertensive patients. Knowledge of recommended salt intake is inappropriate for patients with education of a low–salt diet.


      PubDate: 2014-12-10T10:41:33Z
       
  • Editorial Board
    • Abstract: Publication date: December 2014
      Source:Journal of the American Society of Hypertension, Volume 8, Issue 12




      PubDate: 2014-12-10T10:41:33Z
       
  • Table of Contents
    • Abstract: Publication date: December 2014
      Source:Journal of the American Society of Hypertension, Volume 8, Issue 12




      PubDate: 2014-12-10T10:41:33Z
       
  • The effect of simvastatin and pravastatin on arterial blood pressure,
           baroreflex, vasoconstrictor, and hypertensive effects of angiotensin II in
           Sprague–Dawley rats
    • Abstract: Publication date: December 2014
      Source:Journal of the American Society of Hypertension, Volume 8, Issue 12
      Author(s): Adrian Drapala , Marta Aleksandrowicz , Tymoteusz Zera , Mariusz Sikora , Janusz Skrzypecki , Ewa Kozniewska , Marcin Ufnal
      Research suggests that statins affect the regulation of arterial blood pressure (BP), however, the mechanisms remain obscure. We maintained male, 12–week–old, Sprague–Dawley rats on tap water (controls) or water containing simvastatin or pravastatin for 4 weeks. Subsequently, we measured mean arterial blood pressure and heart rate at baseline and after intravenous infusion of either saline or angiotensin II (Ang II). Additionally, we tested baroreflex function and the effect of statins on vasoconstrictor response to Ang II on isolated femoral artery branches. Controls and simvastatin and pravastatin groups showed a significant increase in mean arterial BP and heart rate in response to Ang II. The increase was significantly smaller in the simvastatin group than in controls and in the pravastatin group. In contrast, when pretreated with hexamethonium, a ganglionic blocker, simvastatin and pravastatin groups showed a similar hypertensive response to Ang II, which was smaller than in controls. Likewise, the Ang II–induced vasoconstrictor response of femoral artery branches was comparable between simvastatin and pravastatin groups and smaller than in controls. We found no effect of statins on the baroreflex. This study shows that simvastatin and pravastatin differ in their effects on the Ang II–dependent mechanisms controlling BP.


      PubDate: 2014-12-10T10:41:33Z
       
  • The Association between Elevated Admission Systolic Blood Pressure in
           Patients with Acute Coronary Syndrome and Favorable Early and Late
           Outcomes
    • Abstract: Publication date: Available online 1 December 2014
      Source:Journal of the American Society of Hypertension
      Author(s): Gadi Shlomai , Eran Kopel , Ilan Goldenberg , Ehud Grossman
      Objectives In patients with acute coronary syndrome (ACS) the predictive potential of admission systolic blood pressure (SBP) on early and late outcomes is not entirely clear. We investigated the association between admission SBP in patients hospitalized for ACS and subsequent morbidity and mortality in a real world setting. Methods The study population comprised 7,645 ACS patients enrolled in the Acute Coronary Syndromes Israeli Survey (ACSIS) between 2002 and 2010. We analyzed the association between admission SBP, and the rates of 7-day and 1-year all-cause mortality and of 30-day major cardiovascular adverse events (MACE). Admission SBP was categorized as low (<110 mmHg), normal (110-140 mmHg), high (141-160 mmHg) and very high (>160 mmHg). Results Compared to patients with normal admission SBP, those with low SBP had a significantly increased hazard ratios (HRs) for 7-day and 1-year mortality, and MACE of 2.37, 1.92, 1.51, respectively (all p <0.001). In contrast, patients with very high admission SBP had significantly decreased HRs for 7-and 1-year mortality, and MACE of 0.46, 0.65, 0.84, respectively (p=0.004, <0.001, 0.07, respectively). Conclusion In patients with ACS, elevated admission SBP is associated with favorable early and late outcomes.


      PubDate: 2014-12-06T10:09:30Z
       
  • Diagnosis of preeclampsia with soluble Fms-like tyrosine kinase
           1/placental growth factor ratio: An inter-assay comparison
    • Abstract: Publication date: Available online 3 December 2014
      Source:Journal of the American Society of Hypertension
      Author(s): Louise Bjørkholt Andersen , Britta Frederiksen-Møller , Kathrine Work Havelund , Ralf Dechend , Jan Stener Jørgensen , Boye L. Jensen , Jan Nielsen , Sine Lykkedegn , Torben Barington , Henrik Thybo Christesen
      The angiogenic factor ratio soluble Fms-kinase 1 (sFlt-1)/placental growth factor (PlGF) is a novel diagnostic tool for preeclampsia. We compared the efficacy of the KRYPTOR, BRAHMS automated assays for sFlt-1 and PlGF with the Elecsys, Roche assays in a routine clinical setting. Preeclamptic women (n=39) were included shortly after the time of diagnosis. Normotensive control pregnancies were matched by gestational age (n=76). The KRYPTOR assays performed comparably or superior to Elecsys (sFlt-1/PlGF area under the curve (AUC) 0.746 vs. 0.735, p=0.09; for non-obese 0.820 vs. 0.805, p=0.047). For early-onset preeclampsia, KRYPTOR AUC increased to 0.929 with a 100% specificity for preeclampsia at cut-off 85 and a 88.9% sensitivity for preeclampsia at cut-off 33. For women with preeclampsia and preterm delivery or HELLP, the KRYPTOR sFlt-1/PlGF ratio was manifold increased (p<0.01). The sFlt-1/PlGF ratio proved especially useful in early-onset preeclampsia, preeclampsia with preterm delivery or HELLP and among non-obese.


      PubDate: 2014-12-06T10:09:30Z
       
  • Use of metabolomics to elucidate the metabolic perturbation associated
           with hypertension in a black South African male cohort: The SABPA Study
    • Abstract: Publication date: Available online 3 December 2014
      Source:Journal of the American Society of Hypertension
      Author(s): Cynthia A. van Deventer , Jeremie Z. Lindeque , Peet J. Jansen van Rensburg , Leoné Malan , Francois H. van der Westhuizen , Roan Louw
      There is concern about the increasing burden of essential hypertension in urban dwelling black South Africans, especially males. Several studies have investigated urbanization and hypertension in South Africans, but in-depth metabolomics studies on these urbanized hypertensives are still lacking. We aimed to investigate hypertension via two metabolomics methods in order to explore underlying biological mechanisms, demonstrating the effectiveness of these methods in cardiovascular research. A comprehensive characterization of a group (n = 25) of black male South Africans was performed using urinary gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS) metabolic profiling in conjunction with 24hour ambulatory blood pressure readings and anthropometric-, clinical- and biochemical markers. Average 24hour blood pressure readings served as grouping variable and test subjects were divided into quintiles. Statistical analyses were performed on Quintile 1 (normotensive subjects) and Quintile 5 (extreme hypertensive subjects). After feature selection was performed, several metabolites and cardiometabolic risk markers, including abdominal obesity and markers of liver damage, inflammation and oxidative stress were significantly perturbed in Quintile 5 (hypertensives) compared to Quintile 1 (P < 0.05). Pathway analysis revealed perturbations in several systems involved in ethanol metabolism via shifted global NADH/NAD+ ratio. Although alcohol abuse has been established as a risk factor for hypertension, this study illustrated a metabolic perturbation associated with alcohol abuse, contributing to the development of hypertension – possibly by altering bioenergetics through a shift in the NADH/NAD+ ratio. Following this finding, future intervention studies on alcohol moderation, as well as further enhancement of metabolomics methods in cardiovascular research are highly recommended.


      PubDate: 2014-12-06T10:09:30Z
       
  • Effects of high and low salt intake on left ventricular remodeling after
           myocardial infarction in normotensive rats
    • Abstract: Publication date: Available online 3 December 2014
      Source:Journal of the American Society of Hypertension
      Author(s): Ludimila Forechi , Marcelo Perim Baldo , Isabela Binotti de Araujo , Breno Valentim Nogueira , José Geraldo Mill
      The dietary-sodium restriction is a standard approach following an acute myocardial infarction (MI). We examined the hypothesis in which the use of high or low-sodium diet would worsen post-infarction left ventricular remodeling in rats and facilitate the development of heart failure. Left coronary artery ligation or sham-operated (SO) was produced in male Wistar rats (250-290 g). After surgery, animals were assigned to one of the three diets: standard amount of sodium (0.3% NaCl, SO and MI groups), a high-sodium diet (0.6% NaCl, SO-High and MI-High groups) or a low-sodium diet (0.03% NaCl, SO-Low and MI-Low groups). Diets were provided for 8 weeks post-surgery. Mortality rate was elevated in high-salt group (MI-Low: 21.4%, MI: 35.3%, MI-High: 47.6%). Contractility parameter was seen to be impaired in MI-Low animals (3195±211 mmHg/s) compared to MI (3751±200 mmHg/s). Low salt diet did not prevent myocardial collagen deposition (MI-Low: 5.2±0.5%, MI: 5.0±0.4%) nor myocyte hypertrophy (MI-Low: 608±41μ2, MI: 712±53μm2) in left ventricle after MI. High-salt intake increases collagen volume fraction (SO: 3.3±0.4%, SO-High: 4.7±0.4%) in animals sham, but no major changes after MI. Our results show that ventricular remodeling was not altered by immediate introduction of low sodium after MI, and it may be a safe strategy as a therapeutic intervention to avoid volume retention. However, high sodium can be harmful accelerating the postinfaction ventricular remodeling.


      PubDate: 2014-12-06T10:09:30Z
       
  • Diagnostic evaluation Target organ damage: cardiac
    • Abstract: Publication date: November 2014
      Source:Journal of the American Society of Hypertension, Volume 8, Issue 11




      PubDate: 2014-11-23T08:58:26Z
       
  • Diagnostic evaluation Target organ damage: cardiovascular
    • Abstract: Publication date: November 2014
      Source:Journal of the American Society of Hypertension, Volume 8, Issue 11




      PubDate: 2014-11-23T08:58:26Z
       
  • Hypertension and kidney disease
    • Abstract: Publication date: November 2014
      Source:Journal of the American Society of Hypertension, Volume 8, Issue 11




      PubDate: 2014-11-23T08:58:26Z
       
  • Stroke outcomes among participants randomized to chlorthalidone,
           amlodipine or lisinopril in ALLHAT
    • Abstract: Publication date: November 2014
      Source:Journal of the American Society of Hypertension, Volume 8, Issue 11
      Author(s): José-Miguel Yamal , Suzanne Oparil , Barry R. Davis , Michael H. Alderman , David A. Calhoun , William C. Cushman , Herbert F. Fendley , Stanley S. Franklin , Gabriel B. Habib , Sara L. Pressel , Jeffrey L. Probstfield , Sithiporn Sastrasinh
      The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) was a randomized, double–blind, practice–based, active–control, comparative effectiveness trial in 33,357 high–risk hypertensive participants. ALLHAT compared cardiovascular disease outcomes in participants initially treated with an angiotensin–converting enzyme inhibitor (lisinopril), a calcium channel blocker (amlodipine), or a thiazide–type diuretic (chlorthalidone). We report stroke outcomes in 1517 participants in–trial and 1596 additional participants during post–trial passive surveillance, for a total follow–up of 8–13 years. Stroke rates were higher with lisinopril (6-year rate/100 = 6.4) than with chlorthalidone (5.8) or amlodipine (5.5) in–trial but not including post–trial (10-year rates/100 = 13.2 [chlorthalidone], 13.1[amlodipine], and 13.7 [lisinopril]). In–trial differences were driven by race (race-by-lisinopril/chlorthalidone interaction P = .005, race-by-amlodipine/lisinopril interaction P = .012) and gender (gender-by-lisinopril/amlodipine interaction P = .041), separately. No treatment differences overall, or by race or gender, were detected over the 10-year period. No differences appeared among treatment groups in adjusted risk of all–cause mortality including post–trial for participants with nonfatal in-trial strokes. Among Blacks and women, lisinopril was less effective in preventing stroke in–trial than either chlorthalidone or amlodipine, even after adjusting for differences in systolic blood pressure. These differences abated by the end of the post–trial period.


      PubDate: 2014-11-23T08:58:26Z
       
  • Impaired coronary microvascular function and increased intima–media
           thickness in preeclampsia
    • Abstract: Publication date: November 2014
      Source:Journal of the American Society of Hypertension, Volume 8, Issue 11
      Author(s): Faika C. Ciftci , Mustafa Caliskan , Ozgur Ciftci , Hakan Gullu , Ayla Uckuyu , Erzat Toprak , Filiz Yanik
      There is an association between preeclampsia (PE) and excessive morbidity and mortality. Some recent studies have revealed the presence of endothelial dysfunction in PE patients with inflammatory activity. Moreover, it has been argued that the chronic inflammatory state involved in PE leads to an acceleration in atherosclerosis. Accordingly, our goal in this study is to determine whether there is any coronary microvascular dysfunction and increase in the intima–media thickness in patients who had mild PE 5 years before, without the presence of any traditional cardiovascular risk factors. The study included 33 mild PE patients (mild preeclampsia is classified as a blood pressure (BP) of 140/90 mm Hg or higher with proteinuria of 0.3 to 3 g/d) whose mean age was 33.7 years old, and 29 healthy women volunteers whose mean age was 36.1 years old. Each subject was examined using transthoracic echocardiography 5 years after their deliveries. During the echocardiographic examination, coronary flow reserve (CFR) and carotid intima–media thickness (IMT) were measured. There was a statistically lower CFR value in PE patients as compared with controls (2.39 ± 0.48 vs. 2.90 ± 0.49; P < .001). On the other hand, there was a significant increase in their IMT and high–sensitivity C–reactive protein (hs–CRP) values (respectively, 0.59 ± 0.15 vs. 0.46 ± 0.10; P < .001 and 3.80 ± 2.10 vs. 2.33 ± 1.79; P = .004). There was a negative correlation between the CFR values of the PE patients and hs-CRP (r = −0.568; P = .001) and IMT (r = −0.683, P < .001) results.We determined in the study that there was impaired CFR and increased carotid IMT in patients with PE, and, moreover, that these adverse effects were significantly correlated with hs-CRP.


      PubDate: 2014-11-23T08:58:26Z
       
  • Wrist circumference as a novel predictor of hypertension and
           cardiovascular disease: results of a decade follow up in a West Asian
           cohort
    • Abstract: Publication date: November 2014
      Source:Journal of the American Society of Hypertension, Volume 8, Issue 11
      Author(s): Reza Mohebi , Ahmad Mohebi , Farhad Sheikholeslami , Fereidoun Azizi , Farzad Hadaegh
      No study has yet evaluated the effect of wrist circumference on risk of incident hypertension and cardiovascular disease (CVD) in an adult population. The present study included 3642 women, aged ≥30 years, free of CVD at baseline, who had undergone health examinations between January 1999 and 2001 and were followed up until March 2010. Cox proportional hazard regression was performed to assess the hazard ratios (HRs) of wrist circumference for CVD and hypertension events. During 10 years of follow–up, 284 cases of first CVD and 615 cases of incident hypertension occurred. In a model adjusted for conventional CVD risk factors, the HR of 1 cm increase in wrist circumference was 1.15 (1.06–1.25) for hypertension and was marginally significant for CVD (HR, 1.12 [1.00–1.25]; P-value 0.052). After considering body mass index and waist circumference in the model, we found significant interaction between waist circumference and wrist circumference in risk prediction of hypertension and CVD (P < .001). In non–centrally obese women (waist circumference <95 cm), in multivariable model plus body mass index and waist circumference, increase in wrist circumference was independently associated with both hypertension (HR, 1.17 [1.02–1.35]) and CVD (HR, 1.29 [1.03–1.61]). However, among centrally obese women (waist circumference ≥95 cm), wrist circumference increase could not predict either hypertension (HR, 0.97 [0.84–1.18]) or CVD events (HR, 0.90 [0.75–1.07]). Wrist circumference as a novel anthropometric measure was an independent predictor for incident hypertension and CVD events among non–centrally obese women.


      PubDate: 2014-11-23T08:58:26Z
       
  • Editorial Board
    • Abstract: Publication date: November 2014
      Source:Journal of the American Society of Hypertension, Volume 8, Issue 11




      PubDate: 2014-11-23T08:58:26Z
       
  • Table of Contents
    • Abstract: Publication date: November 2014
      Source:Journal of the American Society of Hypertension, Volume 8, Issue 11




      PubDate: 2014-11-23T08:58:26Z
       
  • Is all hypertension local?
    • Abstract: Publication date: November 2014
      Source:Journal of the American Society of Hypertension, Volume 8, Issue 11
      Author(s): John D. Bisognano



      PubDate: 2014-11-23T08:58:26Z
       
  • Pre-existing arterial hypertension as a risk factor for early left
           ventricular systolic dysfunction following (R)-CHOP chemotherapy in
           patients with lymphoma
    • Abstract: Publication date: November 2014
      Source:Journal of the American Society of Hypertension, Volume 8, Issue 11
      Author(s): Sebastian Szmit , Wojciech Jurczak , Jan Maciej Zaucha , Joanna Drozd-Sokołowska , Wojciech Spychałowicz , Monika Joks , Monika Długosz-Danecka , Adam Torbicki
      Experimental studies in animals suggest that arterial hypertension may be a specific risk factor predisposing to anthracycline cardiotoxicity. The aim was determination of the effect of pre–existing arterial hypertension on the development of early left ventricular systolic dysfunction (LVSD) directly after rituximab, cyclophosphamide, doxorubicin, vincristin, prednisone ([R]-CHOP) chemotherapy in patients with lymphomas.The study included 208 patients with non-Hodgkin's lymphoma receiving conventional doxorubicin. LVSD was defined as a decrease of left ventricular ejection fraction below 50% and at least by 10 percentage points from baseline value. Patients with pre-existing hypertension more frequently developed new LVSD (19.7% vs. 6.6%; P = .004), pitting edema of the ankles (23.9% vs. 9.5%; P = .005), and nycturia (21.1% vs. 7.3%; P = .004) compared with patients without hypertension. As a consequence, the hypertension subgroup suffered from more delays of subsequent chemotherapy cycles (26.8% vs. 14.6%; P = .03), more reductions of doxorubicin doses (18.3% vs. 8.8%; P = .05), and premature discontinuations of chemotherapy (16.9% vs. 7.3%; P = .03). On logistic regression analyses, hypertension was one of the most important risk factors for developing new LVSD after (R)-CHOP chemotherapy.Arterial hypertension confers a significant risk of early LVSD in lymphoma patients treated with (R)-CHOP chemotherapy, interfering with its recommended schedule of administration.


      PubDate: 2014-11-23T08:58:26Z
       
  • Comparison of an In-Pharmacy Automated Blood Pressure Kiosk to Daytime
           Ambulatory Blood Pressure in Hypertensive Subjects
    • Abstract: Publication date: Available online 20 November 2014
      Source:Journal of the American Society of Hypertension
      Author(s): Raj S. Padwal , Raymond R. Townsend , Luc Trudeau , Peter G. Hamilton , Mark Gelfer
      background /Objectives: To compare serial readings from an in-pharmacy automated BP kiosk to mean daytime ambulatory BP. subjects /Methods: 100 community-dwelling adults with hypertension underwent: a. three baseline automated office readings; b. three in-pharmacy readings on each of four visits (12 total) using the PharmaSmart PS-2000 kiosk; and c. 24-hour ambulatory BP monitoring between in-pharmacy visits two and three. Paired t-tests, Bland-Altman plots and Pearson’s correlation coefficients were used for analysis. Results Mean BPs were 137.8±13.7/81.9±12.2 mmHg for in-pharmacy and 135.5±11.7/79.7±10.0 mmHg for daytime ambulatory (difference of 2.3±9.5/2.2±6.9 mmHg [p=<0.05]). Bland-Altman plots depicted a high degree of blood pressure variability but did not show clinically important systematic BP differences. With ambulatory BP as the reference standard, in-pharmacy device results were similar to automated office. Conclusions The PharmaSmart PS-2000 closely approximated mean daytime ambulatory BP, supporting the use of serial readings from this device in the assessment of BP.


      PubDate: 2014-11-23T08:58:26Z
       
  • Plasma visfatin/nicotinamide phosphoribosyltransferase levels in
           hypertensive elderly – results from the Polsenior substudy
    • Abstract: Publication date: Available online 12 November 2014
      Source:Journal of the American Society of Hypertension
      Author(s): Piotr Kocelak , Magdalena Olszanecka-Glinianowicz , Aleksander Owczarek , Maria Bożentowicz-Wikarek , Aniceta Brzozowska , Małgorzata Mossakowska , Tomasz Zdrojewski , Tomasz Grodzicki , Andrzej Więcek , Jerzy Chudek
      Visfatin/nicotinamide phosphoribosyltransferase (NAMPT), is a 52 kDa adipokine with proinflammatory properties produced mostly by macrophages and adipocytes from visceral adipose tissue. It seems that visfatin/NAMPT plays a role in the pathogenesis of arterial hypertension. As this condition is frequently present in elderly the aim of the study was to assess the plasma visfatin/NAMPT levels in normotensive and hypertensive subjects from the Polish elderly population. Visfatin/NAMPT levels were measured by specific ELISA method in plasma samples from 2789 elderly subjects (1338 females, 1451 males) without heart failure, the PolSenior study participants, in addition to previously estimated serum concentrations of insulin, glucose, creatinine, CRP, and interleukin-6. Homeostasis model assessment for insulin resistance (HOMA-IR) was calculated and used as a marker of insulin resistance. In the study group 591 subjects were normotensive, 449 had untreated and 1749 treated hypertension. Plasma visfatin/NAMPT levels were not related to the presence of hypertension or the use of antihypertensive drugs, including angiotensin converting enzyme inhibitors and angiotensin receptor antagonists. The regression analysis revealed that plasma visfatin/NAMPT concentration variability is increased in subjects with hs-CRP concentration above 3 mg/L and with HOMA-IR≥2.5, and decreased in those aged over 80 years. Our study shows that the presence of hypertension is not associated with the plasma levels of visfatin/NAMPT in elderly subjects. Plasma visfatin/NAMPT concentrations positively correlate with inflammation and insulin resistance, and are decreased in the oldest.


      PubDate: 2014-11-15T08:28:09Z
       
  • SGLT2 Inhibitors: Their Potential Reduction in Blood Pressure
    • Abstract: Publication date: Available online 12 November 2014
      Source:Journal of the American Society of Hypertension
      Author(s): George Maliha , Raymond R. Townsend
      The Sodium Glucose Co-Transporter 2 (SGLT2) inhibitors represent a promising treatment option for diabetes and its common co-morbidity, hypertension. Emerging data suggests that the SGLT2 inhibitors provide a meaningful reduction in blood pressure, although the precise mechanism of the blood pressure drop remains incompletely elucidated. Based on current data, the blood pressure reduction is partially due to a combination of diuresis, nephron remodeling, reduction in arterial stiffness, and weight loss. While current trials are underway focusing on cardiovascular endpoints, the SGLT2 inhibitors present a novel treatment modality for diabetes and its associated hypertension as well as an opportunity to elucidate the pathophysiology of hypertension in diabetes.


      PubDate: 2014-11-15T08:28:09Z
       
  • Elevated systolic blood pressure is associated with increased incidence of
           chronic kidney disease but not mortality in elderly veterans
    • Abstract: Publication date: Available online 6 November 2014
      Source:Journal of the American Society of Hypertension
      Author(s): James W. Lohr , Mojgan Golzy , Randolph L. Carter , Pradeep Arora
      The optimal blood pressure to prevent development of chronic kidney disease (CKD) and mortality in the elderly is unclear. Our objective was to determine the effect of differing levels of blood pressure on incidence of CKD and mortality in elderly veterans. This retrospective cohort study included 15,221 individuals ≥ 70 years of age without chronic kidney disease (outpatient eGFR> 60 ml/min/ 1.73 m2) seen in primary care clinic in VISN2 between 2001 and 2008. To examine the association of explanatory variables on hazard ratios for outcomes of interest, incident CKD and death, competing risk analysis (with death as competing risk) was used for the analysis of incident CKD outcome and time dependent Cox model with CKD as time dependent covariate was used for the analysis of death outcome. The incidence of CKD was 16% over a median follow up of 19 quarters. Compared to reference of systolic blood pressure of 130-139 mmHg , there was an increased hazard of development of CKD with systolic blood pressure of 140-149 mmHg or higher. As compared to a reference range of 130-139 mmHg systolic blood pressure, the relative risk of mortality was higher in the range of 120-129 mmHg systolic or less. The optimal achieved systolic blood pressure in elderly patients to prevent the development of CKD was < 140 mmHg. However, lowering the systolic blood pressure below 130 mmHg was associated with increased mortality.


      PubDate: 2014-11-11T08:11:10Z
       
  • Prevalence of AT1R-activating autoantibodies in primary aldosteronism
    • Abstract: Publication date: Available online 23 October 2014
      Source:Journal of the American Society of Hypertension
      Author(s): Hongliang Li , Xichun Yu , Maria Verena Cicala , Franco Mantero , Alexandria Benbrook , Vineet Veitla , Madeleine W. Cunningham , David C. Kem
      Background Autoantibodies to the angiotensin II type 1 receptor (AT1R) have been reported in patients with primary aldosteronism including aldosterone producing adenoma (APA) and idiopathic adrenal hyperplasia (IAH). Methods and Results Sera from 25 primary aldosteronism subjects (12 with IAH and 13 with APA) and 15 normotensive control subjects were assayed for AT1R autoantibodies by ELISA and an AT1R-transfected cell-based bioassay. Nine of 12 IAH subjects (75%) and 6 of 13 APA subjects (46%) were positive for AT1R autoantibodies in the bioactivity assay. The mean AT1R autoantibody activity for the IAH and APA subjects was significantly greater than controls (P<0.001 and P<0.01, respectively), and this in vitro activity was suppressed by the AT1R blocker losartan. None of the controls had significant AT1R autoantibody activity. ELISA values were less sensitive but were positive in some subjects with IAH and APA. The mean arterial pressure of these primary aldosteronism subjects correlated modestly with AT1R autoantibody activity. Conclusion These data confirm the presence of active AT1R autoantibodies in a high percentage of subjects with primary aldosteronism irrespective of their underlying etiology. These observations have both pathophysiological and clinical implications.


      PubDate: 2014-10-24T07:04:07Z
       
  • Secondary Hypertension: Drugs and Herbal Preparations that Increase
           Pressure
    • Abstract: Publication date: Available online 18 October 2014
      Source:Journal of the American Society of Hypertension
      Author(s): Gary E. Sander



      PubDate: 2014-10-24T07:04:07Z
       
  • Comparison of the renal hyperemic effects of papaverine and dopamine in
           patients with renal artery stenosis
    • Abstract: Publication date: Available online 18 October 2014
      Source:Journal of the American Society of Hypertension
      Author(s): Marcin Protasiewicz , Karol Początek , Rafał Poręba , Maciej Podgórski , Katarzyna Gosławska , Anna Szymańska - Chabowska , Grzegorz Mazur , Andrzej Mysiak , Adam Witkowski
      Aim The purpose of this study was to assess the hyperemic effects of papaverine and dopamine in the renal microcirculation of hypertensive patients with renal artery stenosis (RAS). Background Although a poor correlation between angiographic lesion assessment and its hemodynamic significance is known, angiography is a major criterion for the decision of renal artery stenting. Assessment of the hyperemic translesional pressure gradient was recently shown to be conducive in identifying patients who may benefit from renal revascularization. Methods The study included 14 patients (66±11.2 years) with resistant hypertension and moderate RAS. Using a pressure-sensing catheter, systolic, diastolic, and mean translesional pressure gradients, and the distal pressure (Pd):aortic pressure (Pa) ratio (SG, DG, MG, and Pd/Pa, respectively) were analyzed at baseline and after administration of 40 mg papaverine and 50 μg/kg dopamine. Results We did not observe significant changes in DG. Dopamine administration resulted in significant changes in SG, MG, and Pd/Pa when compared with baseline (p<0.05 for all). Changes in these parameters were caused by a decrease in systolic Pd in comparison with baseline conditions (119±34 mm Hg vs. 101 mm Hg, p<0.05). Systolic Pd pressure after papaverine (104 mm Hg) did not change significantly. Systolic and diastolic Pa values did not differ from baseline after either dopamine or papaverine bolus administration. Conclusions This study indicates that compared with papaverine, the intrarenal bolus of dopamine in hypertensive patients with RAS remains a more powerful hyperemic agent.
      Teaser In hypertensive patients with renal artery stenosis, translesional pressure gradients and the distal pressure:aortic pressure ratio were analyzed at baseline and after administration of 40 mg papaverine and 50 μg/kg dopamine using a pressure-sensing catheter. Dopamine administration resulted in significant changes in measured pressures when compared with baseline. The study indicates that compared with papaverine, the intrarenal bolus of dopamine in hypertensive individuals with renal artery stenosis remains a more powerful hyperemic agent.

      PubDate: 2014-10-24T07:04:07Z
       
  • Secondary Hypertension: Renovascular Hypertension
    • Abstract: Publication date: Available online 17 October 2014
      Source:Journal of the American Society of Hypertension
      Author(s): Stephen Textor



      PubDate: 2014-10-18T06:20:06Z
       
  • Diagnostic Evaluation: Ambulatory Blood Pressure Monitoring in Clinical
           Hypertension Management
    • Abstract: Publication date: Available online 17 October 2014
      Source:Journal of the American Society of Hypertension
      Author(s): William B. White
      For nearly 4 decades, studies have supported direct and independent association of cardiovascular risk with observed ambulatory blood pressure (BP) and inverse association with the degree of BP reduction from day to night. The daytime and nighttime mean BPs as well as the difference between daytime mean and night-time mean BP derived from ambulatory BP monitoring (ABPM) data allow the identification of high-risk patients independent from the BP obtained in the clinic or office setting. The loss of the nocturnal dipping pattern and isolated nocturnal hypertension have also been shown to be an independent risk factors for increased cardiovascular morbidity and mortality. While ABPM is not necessarily required for routine use for the diagnosis of hypertension, its does offer substantial benefit to identify white-coat and masked hypertension and to evaluate the extent (or lack of) of BP control in high-risk patients. Ambulatory BP monitoring has proven to be particularly valuable in clinical evaluation of antihypertensive therapy, including both drugs and devices.


      PubDate: 2014-10-18T06:20:06Z
       
  • From The Editor
    • Abstract: Publication date: Available online 13 October 2014
      Source:Journal of the American Society of Hypertension
      Author(s): Myron H. Weinberger



      PubDate: 2014-10-18T06:20:06Z
       
  • The role of paced breathing in hypertension treatment- a review
    • Abstract: Publication date: Available online 16 October 2014
      Source:Journal of the American Society of Hypertension
      Author(s): Relu Cernes , Reuven Zimlichman
      Despite a good adherence to lifestyle modifications and antihypertensive drugs, hypertension remains resistant in more than a third of patients, thus creating the need for additional strategies, including nonpharmacological approaches. Slow and deep breathing (“paced breathing”) associated in the past with meditation has a direct antihypertensive effect by increasing baroreflex sensitivity (BRS) .With the method of guiding the pace of breathing, a FDA certified device, RESPeRATE®, may offer an easy, efficient, inexpensive and noninvasive option for treating hypertension. Multiple studies showed a significant reduction of blood pressure when RESPeRATE® was evaluated in a home and office setting. In conclusion, this review outlines the pathophysiologic background of paced respiration, describes RESPeRATE clinical trials, and presents briefly other guided breathing alternatives.


      PubDate: 2014-10-18T06:20:06Z
       
  • Rates, Amounts, and Determinants of Ambulatory Blood Pressure Monitoring
           Claim Reimbursements Among Medicare Beneficiaries
    • Abstract: Publication date: Available online 2 October 2014
      Source:Journal of the American Society of Hypertension
      Author(s): Shia T. Kent , Daichi Shimbo , Lei Huang , Keith M. Diaz , Anthony J. Viera , Meredith Kilgore , Suzanne Oparil , Paul Muntner
      Ambulatory blood pressure monitoring (ABPM) can be used to identify white coat hypertension and guide hypertensive treatment. We determined the percentage of ABPM claims submitted between 2007-2010 that were reimbursed. Among 1,970 Medicare beneficiaries with submitted claims, ABPM was reimbursed for 93.8% of claims that had an ICD-9 diagnosis code of 796.2 (“elevated blood pressure reading without diagnosis of hypertension”) versus 28.5% of claims without this code. Among claims without an ICD-9 diagnosis code of 796.2 listed, those for the component (e.g., recording, scanning analysis, physician review, reporting) versus full ABPM procedures and performed by institutional versus non-institutional providers were each more than two times as likely to be successfully reimbursed. Of the claims reimbursed, the median payment was $52.01 (25-75th percentiles: $32.95-$64.98). In conclusion, educating providers on the ABPM claims reimbursement process and evaluation of Medicare reimbursement may increase the appropriate use of ABPM and improve patient care.


      PubDate: 2014-10-04T04:42:38Z
       
  • Hypertension and Kidney Disease
    • Abstract: Publication date: Available online 17 September 2014
      Source:Journal of the American Society of Hypertension
      Author(s): Matthew R. Weir



      PubDate: 2014-09-19T02:55:50Z
       
  • Diagnostic Evaluation: Target Organ Damage: Cardiac
    • Abstract: Publication date: Available online 17 September 2014
      Source:Journal of the American Society of Hypertension
      Author(s): Scott D. Solomon



      PubDate: 2014-09-19T02:55:50Z
       
  • Diagnostic Evaluation: Target Organ Damage - Cardiovascular
    • Abstract: Publication date: Available online 17 September 2014
      Source:Journal of the American Society of Hypertension
      Author(s): John B. Kostis



      PubDate: 2014-09-19T02:55:50Z
       
  • From the editor
    • Abstract: Publication date: Available online 16 September 2014
      Source:Journal of the American Society of Hypertension
      Author(s): Myron H. Weinberger



      PubDate: 2014-09-19T02:55:50Z
       
  • Onset of hypertension during pregnancy is associated with long-term worse
           blood pressure control and adverse cardiac remodeling
    • Abstract: Publication date: Available online 8 September 2014
      Source:Journal of the American Society of Hypertension
      Author(s): Roberto F. Mesquita , Muriel Reis , Ana Paula Beppler , Vera Regina Bellinazzi , Sandra S. Mattos , José L. Lima-Filho , José A. Cipolli , Otavio R. Coelho-Filho , José A. Pio-Magalhães , Andrei C. Sposito , José R. Matos-Souza , Wilson Nadruz Jr.
      Up to 20% of women with hypertensive pregnancy disorders might persist with chronic hypertension. This study compared clinical and echocardiographic features between women whose hypertension began as hypertensive pregnancy disorders (PH group) and women whose diagnosis of hypertension did not occur during pregnancy (NPH group). Fifty PH and 100 NPH women were cross-sectionally evaluated by clinical, laboratory and echocardiography analysis and the groups were matched by duration of hypertension. PH exhibited lower age (46.6±1.4 vs. 65.3±1.1 years; p<0.001), but higher systolic (159.8±3.9 vs. 148.0±2.5mmHg; p=0.009) and diastolic (97.1±2.4 vs. 80.9±1.3mmHg; p<0.001) blood pressure than NPH, although used more antihypertensive classes (3.4±0.2 vs. 2.6±0.1; p<0.001). Furthermore, PH showed higher left ventricular wall thickness and increased prevalence of concentric hypertrophy than NPH after adjusting for age and blood pressure. In conclusion, this study showed that PH may exhibit worse blood pressure control and adverse left ventricular remodeling compared to NPH.


      PubDate: 2014-09-09T01:41:36Z
       
  • The effects of the spleen tyrosine kinase inhibitor fostamatinib on
           ambulatory blood pressure in patients with active rheumatoid arthritis:
           Results of the OSKIRA-ABPM (ambulatory blood pressure monitoring)
           randomized trial
    • Abstract: Publication date: Available online 4 September 2014
      Source:Journal of the American Society of Hypertension
      Author(s): George D. Kitas , Gabriel Abreu , Krystyna Jedrychowicz-Rosiak , Jeffrey L. Miller , Roumen Nakov , Seva Panfilov , Jiri Vencovsky , Millie Wang , Michael E. Weinblatt , William B. White
      Clinical trials of fostamatinib in patients with rheumatoid arthritis (RA) showed blood pressure (BP) elevation using clinic measurements. The OSKIRA-ambulatory BP monitoring (ABPM) trial assessed fostamatinib’s effect on 24-hour ambulatory systolic BP (SBP) in patients with active RA. One hundred thirty-five patients were randomized to fostamatinib 100 mg twice daily (bid) (n = 68) or placebo bid (n = 67) for 28 days. Ambulatory, clinic, and home BPs were measured at baseline and after 28 days of therapy. Primary end point was change from baseline in 24-hour mean SBP. Fostamatinib increased 24-hour mean SBP by 2.9 mmHg (P = .023) and diastolic BP (DBP) by 3.5 mmHg (P < .001) vs. placebo. Clinic/home-measured BPs were similar to those observed with ABPM. After treatment discontinuation (1 week), clinic BP values returned to baseline levels. Fostamatinib induced elevations in 24-hour mean ambulatory SBP and DBP. BP elevations resolved with fostamatinib discontinuation.


      PubDate: 2014-09-09T01:41:36Z
       
  • Maternal hypertensive pregnancy disorders and cognitive functioning of the
           offspring: A systematic review
    • Abstract: Publication date: Available online 8 September 2014
      Source:Journal of the American Society of Hypertension
      Author(s): Soile Tuovinen , Johan G. Eriksson , Eero Kajantie , Katri Räikkönen
      Hypertensive pregnancy disorders may affect the fetal developmental milieu and thus hint at mechanisms that link prenatal conditions with later developmental outcomes of the offspring. Here, we systematically review studies that have tested whether maternal pre-eclampsia, gestational hypertension and hypertensive pregnancy disorders as a single diagnostic entity are associated with cognitive functioning of the offspring. Twenty-six studies were eligible for this review. Of them, 19 provided detailed methodological information deemed necessary to be included for a more detailed review. An overall conclusion is that, in the general population, maternal hypertensive disorders may be associated with lower cognitive ability of the offspring. Studies that extend to adulthood show the most consistent pattern of findings. It is possible that the associations arise during the lifetime or that the findings reflect improvements in management of these disorders. Evidence is, however, insufficient to conclude whether these associations are dissimilar in the offspring exposed to maternal pre-eclampsia and gestational hypertension, due to the varied criteria used across the different studies to distinguish between these conditions. The existing studies also vary in the definition of control groups, and very few have taken into account important confounding factors, including maternal pre-pregnancy obesity and lifestyle behaviors. Given the mixed pattern of findings and limitations related to internal and external validity, further studies are clearly warranted to clarify the associations.


      PubDate: 2014-09-09T01:41:36Z
       
 
 
JournalTOCs
School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
Email: journaltocs@hw.ac.uk
Tel: +00 44 (0)131 4513762
Fax: +00 44 (0)131 4513327
 
About JournalTOCs
API
Help
News (blog, publications)
JournalTOCs on Twitter   JournalTOCs on Facebook

JournalTOCs © 2009-2014