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  Subjects -> HISTORY (Total: 1291 journals)
    - HISTORY (809 journals)
    - History (General) (51 journals)
    - HISTORY OF AFRICA (49 journals)
    - HISTORY OF ASIA (55 journals)
    - HISTORY OF AUSTRALASIA AREAS (7 journals)
    - HISTORY OF EUROPE (168 journals)
    - HISTORY OF THE AMERICAS (128 journals)
    - HISTORY OF THE NEAR EAST (24 journals)

HISTORY (809 journals)            First | 1 2 3 4 5     

Showing 601 - 452 of 452 Journals sorted alphabetically
Préhistoires méditerranéennes     Open Access   (Followers: 2)
Proceedings of the Aristotelian Society (hardback)     Hybrid Journal   (Followers: 4)
Proceedings of the Institution of Civil Engineers - Engineering History and Heritage     Hybrid Journal   (Followers: 3)
Proceedings of the Linnean Society of New South Wales     Full-text available via subscription   (Followers: 1)
Proceedings of the Royal Society of Queensland, The     Full-text available via subscription   (Followers: 1)
Proceedings of the Zoological Society     Hybrid Journal   (Followers: 2)
Procesos Historicos     Open Access  
Prose Studies: History, Theory, Criticism     Hybrid Journal   (Followers: 3)
Psychoanalysis and History     Hybrid Journal   (Followers: 3)
Psychoanalysis Culture & Society     Hybrid Journal   (Followers: 8)
Publications du Centre Européen d'Etudes Bourguignonnes     Full-text available via subscription  
Purdue Historian     Open Access  
Quaderns d’Història de l’Enginyeria     Open Access  
Quaker History     Full-text available via subscription   (Followers: 6)
Queensland Naturalist     Full-text available via subscription  
Questes : Revue pluridisciplinaire d'études médiévales     Open Access  
Quintana. Revista de Estudos do Departamento de Historia da Arte     Open Access  
Radical History Review     Full-text available via subscription   (Followers: 24)
Rasenna : Journal of the Center for Etruscan Studies     Open Access   (Followers: 2)
Rationality and Society     Hybrid Journal   (Followers: 6)
Raven : A Journal of Vexillology     Hybrid Journal  
Reinardus     Hybrid Journal  
Relaciones. Estudios de historia y sociedad     Open Access  
Renaissance Drama     Full-text available via subscription   (Followers: 7)
Renaissance Quarterly     Full-text available via subscription   (Followers: 42)
Renaissance Studies     Hybrid Journal   (Followers: 20)
Rethinking History: The Journal of Theory and Practice     Hybrid Journal   (Followers: 26)
Reti Medievali Rivista     Open Access   (Followers: 2)
Review of Central and East European Law     Hybrid Journal   (Followers: 8)
Reviews in American History     Full-text available via subscription   (Followers: 16)
Revista Alétheia     Open Access  
Revista Análisis Internacional     Open Access  
Revista Brasileira de Historia     Open Access   (Followers: 3)
Revista Brasileira de História das Religiões     Open Access  
Revista Chilena de Historia del Derecho     Open Access  
Revista de Divulgação Interdisciplinar     Open Access  
Revista de Estudios Historico-Juridicos     Open Access   (Followers: 1)
Revista de História     Open Access  
Revista de História Bilros. História(s), Sociedade(s) e Cultura(s)     Open Access   (Followers: 1)
Revista de História da UEG     Open Access  
Revista do Instituto Histórico e Geográfico do Rio Grande do Sul     Open Access  
Revista Historia Autónoma     Open Access  
Revista História da Educação - History of Education Journal     Open Access  
Revista Maracanan     Open Access  
Revista Memória em Rede     Open Access  
Revista Mosaico     Open Access  
Revista Paginas     Open Access  
Revolutionary Russia     Hybrid Journal   (Followers: 8)
Revue archéologique de l'Est     Open Access   (Followers: 3)
Revue archéologique du Centre de la France     Open Access   (Followers: 2)
Revue d'histoire de l'Amérique française     Full-text available via subscription   (Followers: 1)
Revue d'Histoire de l'Eglise de France     Full-text available via subscription   (Followers: 3)
Revue d'histoire de l'enfance     Open Access  
Revue d'Histoire des Textes     Full-text available via subscription  
Revue d'histoire du XIXe siècle     Open Access   (Followers: 7)
Revue d'Histoire Ecclésiastique     Full-text available via subscription   (Followers: 1)
Revue de l’Histoire des Religions     Open Access   (Followers: 11)
Revue des Études Arméniennes     Full-text available via subscription   (Followers: 2)
Revue historique des armées     Open Access   (Followers: 3)
Revue Mabillon     Full-text available via subscription   (Followers: 6)
Rhetoric Society Quarterly     Hybrid Journal   (Followers: 15)
RIHA Journal     Open Access   (Followers: 5)
RIMA: Review of Indonesian and Malaysian Affairs     Full-text available via subscription   (Followers: 1)
Romanticism     Hybrid Journal   (Followers: 5)
Romanticism and Victorianism on the Net     Open Access   (Followers: 6)
Royal Studies Journal     Open Access   (Followers: 1)
Rúbrica Contemporánea     Open Access  
Russian Education & Society     Full-text available via subscription   (Followers: 5)
Russian History     Hybrid Journal   (Followers: 15)
Russian Review     Hybrid Journal   (Followers: 19)
Sacris Erudiri     Full-text available via subscription   (Followers: 6)
Saeculum : Jahrbuch für Universalgeschichte     Hybrid Journal   (Followers: 1)
Safundi : The Journal of South African and American Studies     Hybrid Journal   (Followers: 1)
Scandinavian Journal of History     Hybrid Journal   (Followers: 13)
Scando-Slavica     Hybrid Journal   (Followers: 4)
Science & Society     Full-text available via subscription   (Followers: 5)
Science Journal of Volgograd State University. History. Area Studies. International Relations     Open Access  
Scientia Canadensis: Canadian Journal of the History of Science, Technology and Medicine / Scientia Canadensis : revue canadienne d'histoire des sciences, des techniques et de la médecine     Full-text available via subscription   (Followers: 5)
Scientia Militaria : South African Journal of Military Studies     Open Access   (Followers: 5)
Scientiae Studia     Open Access  
Scottish Historical Review     Hybrid Journal   (Followers: 17)
Scrineum Rivista     Open Access  
Scrutiny2: Issues in English Studies in Southern Africa     Hybrid Journal   (Followers: 1)
Senses and Society     Hybrid Journal   (Followers: 4)
SHARE : Studies in History, Archaeology, Religion and Conservation     Open Access  
Sibirica     Full-text available via subscription  
Siècles     Open Access   (Followers: 1)
Signals     Full-text available via subscription   (Followers: 2)
Signos Historicos     Open Access  
Slagmark - Tidsskrift for idéhistorie     Open Access   (Followers: 4)
Slavery & Abolition: A Journal of Slave and Post-Slave Studies     Hybrid Journal   (Followers: 11)
Slavonica     Hybrid Journal   (Followers: 3)
Social History     Hybrid Journal   (Followers: 46)
Social History of Medicine     Hybrid Journal   (Followers: 21)
Social Sciences and Missions     Hybrid Journal   (Followers: 4)
Società e Storia     Full-text available via subscription   (Followers: 1)
Society     Hybrid Journal   (Followers: 5)
Society and Economy     Full-text available via subscription   (Followers: 2)
SourceOECD National Accounts & Historical Statistics     Full-text available via subscription  
South African Historical Journal     Hybrid Journal   (Followers: 6)
South African Journal of Art History     Full-text available via subscription   (Followers: 2)
South African Journal of Cultural History     Full-text available via subscription   (Followers: 1)
South African Journal of Economic History     Full-text available via subscription   (Followers: 3)
South Asia Research     Hybrid Journal   (Followers: 8)
South Asia: Journal of South Asian Studies     Hybrid Journal   (Followers: 14)
South Asian History and Culture     Hybrid Journal   (Followers: 3)
South Asian Popular Culture     Hybrid Journal   (Followers: 2)
South Asian Survey     Hybrid Journal   (Followers: 5)
South Australian Naturalist, The     Full-text available via subscription  
South Central Review     Full-text available via subscription  
South European Society and Politics     Hybrid Journal   (Followers: 9)
Southeast European and Black Sea Studies     Hybrid Journal   (Followers: 5)
Southwestern Historical Quarterly     Full-text available via subscription   (Followers: 5)
Soviet and Post-Soviet Review     Hybrid Journal   (Followers: 9)
Spontaneous Generations : A Journal for the History and Philosophy of Science     Open Access   (Followers: 2)
Sport in History     Hybrid Journal   (Followers: 10)
Studia Aurea : Revista de Literatura Española y Teoría Literaria del Renacimiento y Siglo de Oro     Open Access   (Followers: 1)
Studia Historiae Ecclesiasticae     Open Access   (Followers: 2)
Studia Historiae Oeconomicae     Open Access  
Studia Iranica     Full-text available via subscription   (Followers: 5)
Studia Litteraria et Historica     Open Access  
Studia z Historii Filozofii     Open Access  
Studies in East European Thought     Hybrid Journal   (Followers: 6)
Studies in Eighteenth Century Culture     Full-text available via subscription   (Followers: 20)
Studies in History     Hybrid Journal   (Followers: 24)
Studies in History and Philosophy of Science Part A     Hybrid Journal   (Followers: 8)
Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences     Hybrid Journal   (Followers: 13)
Studies in People’s History     Hybrid Journal  
Studies in the History of Gardens & Designed Landscapes: An International Quarterly     Hybrid Journal   (Followers: 8)
Studies in Western Australian History     Full-text available via subscription   (Followers: 3)
Studium : Tijdschrift voor Wetenschaps- en Universiteits-geschiedenis / Revue d'Histoire des Sciences et des Universités     Open Access   (Followers: 1)
Suomen Sukututkimusseuran Vuosikirja     Open Access  
Sydney Institute Quarterly     Full-text available via subscription  
T'oung Pao     Hybrid Journal   (Followers: 12)
Tangence     Full-text available via subscription  
Tartu Ülikooli ajaloo küsimusi     Open Access  
Tasmanian Historical Studies     Full-text available via subscription   (Followers: 1)
Teaching History     Full-text available via subscription   (Followers: 7)
Technology and Culture     Full-text available via subscription   (Followers: 24)
temp - tidsskrift for historie     Full-text available via subscription  
Tempo     Open Access   (Followers: 2)
Tempo e Argumento     Open Access  
The Corvette     Open Access  
The Court Historian : The International Journal of Court Studies     Full-text available via subscription   (Followers: 1)
The Eighteenth Century     Full-text available via subscription   (Followers: 27)
The European Legacy: Toward New Paradigms     Hybrid Journal   (Followers: 2)
The Hilltop Review : A Journal of Western Michigan University Graduate Student Research     Open Access  
The Historian     Hybrid Journal   (Followers: 33)
The International History Review     Hybrid Journal   (Followers: 21)
The Irish Review     Full-text available via subscription   (Followers: 15)
The Italianist     Hybrid Journal   (Followers: 5)
The Journal of the Historical Society     Hybrid Journal   (Followers: 12)
The Public Historian     Full-text available via subscription   (Followers: 11)
The Seventeenth Century     Hybrid Journal   (Followers: 17)
The Sixties: A Journal of History, Politics and Culture     Hybrid Journal   (Followers: 11)
The South African Journal of Economics     Hybrid Journal   (Followers: 4)
Theatre History Studies     Full-text available via subscription   (Followers: 4)
Theoria et Historia Scientiarum     Open Access  
Tiempo devorado     Open Access  
Tiempo y Espacio     Open Access  
Tijdschrift voor Geschiedenis     Full-text available via subscription   (Followers: 2)
Tijdschrift voor Rechtsgeschiedenis / Revue d'Histoire du Droit / The Legal History Review     Hybrid Journal   (Followers: 21)
Time & Society     Hybrid Journal   (Followers: 10)
Trabajos y Comunicaciones     Open Access   (Followers: 1)
Traditio     Full-text available via subscription   (Followers: 2)
Trans-pasando Fronteras     Open Access  
Transactions of the Philological Society     Hybrid Journal   (Followers: 2)
Transactions of the Royal Society of South Africa     Hybrid Journal   (Followers: 2)
Transfers     Full-text available via subscription  
Transition     Full-text available via subscription   (Followers: 1)
Transmodernity : Journal of Peripheral Cultural Production of the Luso-Hispanic World     Open Access   (Followers: 3)
Trocadero     Open Access  
Troianalexandrina     Full-text available via subscription   (Followers: 1)
Turcica     Full-text available via subscription   (Followers: 10)
Turkish Historical Review     Hybrid Journal   (Followers: 6)
Turkish Studies     Hybrid Journal   (Followers: 11)
Twentieth Century British History     Hybrid Journal   (Followers: 18)
U.S. Catholic Historian     Full-text available via subscription   (Followers: 2)
UCLA Historical Journal     Open Access  
Ufahamu : A Journal of African Studies     Open Access   (Followers: 2)
United Service     Full-text available via subscription   (Followers: 2)
Urban History Review / Revue d'histoire urbaine     Full-text available via subscription   (Followers: 6)
Varia Historia     Open Access   (Followers: 2)
Vegueta : Anuario de la Facultad de Geografía e Historia     Open Access  
Vestiges : Traces of Record     Full-text available via subscription  
Viator     Full-text available via subscription   (Followers: 14)
Victorian Naturalist, The     Full-text available via subscription   (Followers: 3)
Victorian Periodicals Review     Full-text available via subscription   (Followers: 9)
Vigiliae Christianae     Hybrid Journal   (Followers: 12)
Viking and Medieval Scandinavia     Full-text available via subscription   (Followers: 15)
Vínculos de Historia. Revista del Departamento de Historia de la Universidad de Castilla-La Mancha     Open Access  
Visual Resources: An International Journal of Documentation     Hybrid Journal   (Followers: 2)
Vivarium     Hybrid Journal   (Followers: 2)
Vulcan     Hybrid Journal  
War & Society     Hybrid Journal   (Followers: 25)
Water History     Hybrid Journal   (Followers: 11)
Welsh History Review     Full-text available via subscription   (Followers: 13)
West 86th     Full-text available via subscription   (Followers: 5)
West Virginia History: A Journal of Regional Studies     Full-text available via subscription   (Followers: 3)
Whispering Wind     Full-text available via subscription   (Followers: 1)

  First | 1 2 3 4 5     

Journal Cover Journal of the American Society of Hypertension
  [SJR: 1.039]   [H-I: 31]   [9 followers]  Follow
    
   Hybrid Journal Hybrid journal (It can contain Open Access articles)
   ISSN (Print) 1933-1711
   Published by Elsevier Homepage  [3043 journals]
  • “Incremental Prognostic Value of a Complex Left Ventricular Remodelling
           
    • Authors: Nicola Riccardo Pugliese; Iacopo Fabiani; Salvatore La Carrubba; Lorenzo Conte; Francesco Antonini-Canterin; Paolo Colonna; Pio Caso; Frank Benedetto; Veronica Santini; Scipione Carerj; Maria Francesca Romano; Rodolfo Citro; Vitantonio Di Bello
      Pages: 71 - 77
      Abstract: Publication date: Available online 25 May 2017
      Source:Journal of the American Society of Hypertension
      Author(s): Iacopo Fabiani, Nicola Riccardo Pugliese, Salvatore La Carrubba, Lorenzo Conte, Francesco Antonini-Canterin, Paolo Colonna, Frank Benedetto, Valentina Barletta, Enrico Calogero, Scipione Carerj, Simona Buralli, Stefano Taddei, Maria Francesca Romano, Vitantonio Di Bello
      Introduction We evaluated the prognostic impact of a complex remodeling classification (CRC) in asymptomatic patients with Arterial Hypertension (AH). Methods We retrospectively included 749 hypertensive patients (Female 325, 43.4%; Age 62±11.3 years) in stage A and B of heart failure (HF). CRC was evaluated including indexed left ventricular mass, end-diastolic volume, and relative wall thickness. After 45-month follow-up we considered a composite end-point: total mortality, myocardial infarction, myocardial revascularization, cerebrovascular events and acute pulmonary edema. Results Blood pressure was controlled in 265 patients (35.4%), 317 (42.3%) were in Grade 1 of AH, 123 (16.4%) in Grade 2 and 44 (5.9%) in Grade 3. Considering CRC, 292 patients (38%) presented normal/physiologic hypertrophy, 102 (13.6%) concentric remodeling, 29 (3.9%) eccentric remodeling, 157 (21%) concentric hypertrophy, 11 (1.5%) mixed hypertrophy, 52 (6.9%) dilated hypertrophy and 36 (4.8%) eccentric hypertrophy. We observed a total of 73 (9.7%) events. Kaplan-Meier method demonstrated a significant different survival in CRC-derived classes (p<0.001). Cox-regression demonstrated CRC as independent predictor (p=0.01), after adjusting for age, gender, diabetes mellitus, Grade of Hypertension, anti-hypertensive therapy, stable ischemic heart disease, obesity, systolic and diastolic dysfunction, classic remodeling classification. Conclusion In asymptomatic patients with AH, CRC is an independent predictor of poor outcome.

      PubDate: 2017-05-28T05:03:01Z
      DOI: 10.1016/j.amjcard.2016.09.018
      Issue No: Vol. 119, No. 1 (2017)
       
  • Central Systolic Blood Pressure and Aortic Stiffness Response to Dietary
           Sodium in Young and Middle-Aged Adults
    • Authors: Bryce J. Muth; Michael S. Brian; Julio A. Chirinos; Shannon L. Lennon; William B. Farquhar; David G. Edwards
      Abstract: Publication date: Available online 28 July 2017
      Source:Journal of the American Society of Hypertension
      Author(s): Bryce J. Muth, Michael S. Brian, Julio A. Chirinos, Shannon L. Lennon, William B. Farquhar, David G. Edwards
      High dietary sodium intake can lead to hypertension and increased incidence of cardiovascular disease. We sought to determine the effect of short-term dietary sodium loading on central blood pressure and arterial stiffness in young (YG; 22-40 years) and middle-aged (MA; 41-60 years) normotensive adults. YG (n=49; age: 27±1 yrs) and MA (n=36; age: 52±1 yrs) subjects were randomized, in a cross-over design, to 7 days of low sodium (20mmol/day) or high sodium (300mmol/day) diet. On the last day of each diet, central pressures, forward and reflected wave amplitudes (via radial artery applanation tonometry) and carotid-femoral pulse wave velocity (CF-PWV) were assessed. Central systolic blood pressure (cSBP) was greater after HS in both YG (LS: 96±1 vs. HS: 99±1mmHg; p=0.012) and MA (LS: 106±2 vs. HS: 115±3mmHg; p<0.001). However, the increase in cSBP was greater in MA (YG: 4±1 vs. MA: 9±2; p=0.02). In MA subjects, HS elicited greater forward (LS: 25±1 vs. HS: 29±1mmHg; p<0.001) and reflected (LS: 19±1 vs. HS: 23±1mmHg; p<0.001) wave amplitudes. CF-PWV was also greater in MA on HS but after adjustment for MAP the difference was no longer significant. Our data indicate that HS intake leads to a greater increase in cSBP in MA adults, which may be the result of increased forward and reflected wave amplitudes.

      PubDate: 2017-08-03T16:08:26Z
      DOI: 10.1016/j.jash.2017.07.010
       
  • Galectin-3 mediates pulmonary vascular remodeling in hypoxia-induced
           pulmonary arterial hypertension
    • Authors: Hui Luo; Bin Liu; Lin Zhao; Jingni He; Tangzhiming Li; Lihuang Zha; Xiaohui Li; Qiangqiang Qi; Yuwei Liu; Zaixin Yu
      Abstract: Publication date: Available online 28 July 2017
      Source:Journal of the American Society of Hypertension
      Author(s): Hui Luo, Bin Liu, Lin Zhao, Jingni He, Tangzhiming Li, Lihuang Zha, Xiaohui Li, Qiangqiang Qi, Yuwei Liu, Zaixin Yu
      Objective Pulmonary vascular adventitia serves as a key regulator of pulmonary vascular remodeling in the pathogenesis of pulmonary arterial hypertension (PAH). Excessive proliferation and differentiation of pulmonary adventitial fibroblasts (PAFs) are proven to be crucial in the pathogenesis of PAH. Galectin-3 (Gal-3) is known as a key fibroblasts activing factor which is involved in the fibrogenesis of several diseases, such as pulmonary fibrosis, vascular fibrosis, and heart failure. Therefore, we seek to investigate the potential role of Gal-3 in regulating PAF cells in the pathogenesis of PAH. Result Gal-3 plasma concentration was significantly higher in PAH patients. Gal-3 was upregulated in pulmonary artery adventitia of hypoxia-induced PAH rats. Inhibition of Gal-3 with N-Acetyl-D-lactosamine (N-Lac) ameliorated PAH and pulmonary vascular remodeling. Gal-3 can stimulate the proliferation, differentiation and collagen synthesis of PAFs, which was reversed by N-Lac. TGF-β1 increased Gal-3 expression in PAFs, while N-Lac significantly suppressed TGF-β1-induced proliferation, differentiation and collagen synthesis of PAFs. Conclusion Gal-3 serves as a critical regulator in the pathogenesis of PAH by regulating the proliferation, differentiation and extracellular matrix deposition synthesis of PAFs. Inhibition of Gal-3 may represent a novel therapeutic target for PAH treatment.

      PubDate: 2017-08-03T16:08:26Z
      DOI: 10.1016/j.jash.2017.07.009
       
  • Is there a role for very low–dose combination therapy in
           hypertension management'
    • Authors: Brent M. Egan
      Abstract: Publication date: Available online 26 July 2017
      Source:Journal of the American Society of Hypertension
      Author(s): Brent M. Egan


      PubDate: 2017-08-03T16:08:26Z
      DOI: 10.1016/j.jash.2017.07.007
       
  • From the Editor
    • Authors: Daniel Levy
      Abstract: Publication date: July 2017
      Source:Journal of the American Society of Hypertension, Volume 11, Issue 7
      Author(s): Daniel Levy


      PubDate: 2017-08-03T16:08:26Z
       
  • Erratum
    • Abstract: Publication date: July 2017
      Source:Journal of the American Society of Hypertension, Volume 11, Issue 7


      PubDate: 2017-08-03T16:08:26Z
       
  • Instructions for Authors
    • Abstract: Publication date: July 2017
      Source:Journal of the American Society of Hypertension, Volume 11, Issue 7


      PubDate: 2017-08-03T16:08:26Z
       
  • Terminal decline in systolic blood pressure in octogenarians
    • Authors: Michael J. Bloch
      Abstract: Publication date: Available online 23 July 2017
      Source:Journal of the American Society of Hypertension
      Author(s): Michael J. Bloch


      PubDate: 2017-07-23T14:20:28Z
      DOI: 10.1016/j.jash.2017.07.003
       
  • Tumor necrosis factor-α receptor 1 (TNFR1) contributes to ethanol-induced
           vascular reactive oxygen species generation and hypertension
    • Authors: Janaina A. Simplicio; Natália A. Gonzaga; Marcelo A. Nakashima; Bruno S. De Martinis; Thiago Mattar Cunha; Luis F. Tirapelli; Carlos R. Tirapelli
      Abstract: Publication date: Available online 22 July 2017
      Source:Journal of the American Society of Hypertension
      Author(s): Janaina A. Simplicio, Natália A. Gonzaga, Marcelo A. Nakashima, Bruno S. De Martinis, Thiago Mattar Cunha, Luis F. Tirapelli, Carlos R. Tirapelli
      We evaluated the contribution of TNF-α receptor 1 (TNFR1) to ethanol-induced hypertension and vascular oxidative stress and the possible role of perivascular adipose tissue (PVAT) in such response. Male C57BL/6 wild-type (WT) or TNFR1-deficient mice (TNFR1-/-) were treated with ethanol (20% v/v) for 12 weeks. Ethanol induced an increase in blood pressure in WT and TNFR1−/– mice at 4 and 5 weeks of treatment, respectively. Treatment with ethanol increased TNF-α and interleukin (IL)-6 levels in aortas with or without PVAT (PVAT+ and PVAT-, respectively) from WT, but not TNFR1-/- mice. Ethanol increased superoxide anion (O2 -) generation, TBARS concentration and the activity of superoxide dismutase (SOD) and catalase in aortas (PVAT- and PVAT+) from WT, but not TNFR1−/- mice. Conversely, ethanol consumption decreased the concentration of nitrate/nitrite (NOx) in aortas (PVAT- and PVAT+) from WT, but not TNFR1-/- mice. Treatment with ethanol increased myeloperoxidase (MPO) activity in aortas (PVAT- and PVAT+) from WT, but not TNFR1-/- mice. The major finding of our study is that TNFR1 contributes to ethanol-induced hypertension and oxidative stress in the vasculature. Additionally, TNFR1 plays a role in ethanol-induced increase in pro-inflammatory cytokines and neutrophils migration. However, PVAT does not counteract or aggravate the effects induced by ethanol.
      Graphical abstract image

      PubDate: 2017-07-23T14:20:28Z
      DOI: 10.1016/j.jash.2017.07.008
       
  • The Effect of Empagliflozin on Muscle Sympathetic Nerve Activity in
           Patients with Type 2 Diabetes Mellitus
    • Authors: Jens Jordan; Jens Tank; Karsten Heusser; Tim Heise; Christoph Wanner; Martina Heer; Sreeraj Macha; Michaela Mattheus; Søren S. Lund; Hans J. Woerle; Uli C. Broedl
      Abstract: Publication date: Available online 21 July 2017
      Source:Journal of the American Society of Hypertension
      Author(s): Jens Jordan, Jens Tank, Karsten Heusser, Tim Heise, Christoph Wanner, Martina Heer, Sreeraj Macha, Michaela Mattheus, Søren S. Lund, Hans J. Woerle, Uli C. Broedl
      Background Inhibition of sodium glucose cotransporter 2 (SGLT2) with empagliflozin results in caloric loss by increasing urinary glucose excretion and has a mild diuretic effect. Diuretic effects are usually associated with reflex-mediated increases in sympathetic tone, whereas caloric loss is associated with decreased sympathetic tone. Methods and Results In an open-label trial, muscle sympathetic nerve activity (burst frequency, burst incidence and total muscle sympathetic nerve activity) was assessed using microneurography performed off-treatment and on day 4 of treatment with empagliflozin 25 mg once daily in 22 metformin-treated patients with type 2 diabetes (mean [range] age 54 [40–65] years). Systolic and diastolic blood pressure, heart rate, urine volume and body weight were assessed before and on day 4 (blood pressure, heart rate), day 5 (urine volume) or day 6 (body weight) of treatment with empagliflozin. After 4 days of treatment with empagliflozin, no significant changes in muscle sympathetic nerve activity were apparent despite a numerical increase in urine volume, numerical reductions in blood pressure, and significant weight loss. There were no clinically relevant changes in heart rate. Conclusions Empagliflozin is not associated with clinically relevant reflex-mediated sympathetic activation in contrast to increases observed with diuretics in other studies. Our study suggests a novel mechanism through which SGLT2 inhibition affects human autonomic cardiovascular regulation. Clinicaltrials.gov Identifier: NCT01276288.

      PubDate: 2017-07-23T14:20:28Z
      DOI: 10.1016/j.jash.2017.07.005
       
  • Celastrol synergizes with oral nifedipine to attenuate hypertension in
           preeclampsia: a randomized, placebo-controlled and double blinded trial
    • Authors: Sha Xiao; Ming Zhang; Yuan Liang; Deling Wang
      Abstract: Publication date: Available online 20 July 2017
      Source:Journal of the American Society of Hypertension
      Author(s): Sha Xiao, Ming Zhang, Yuan Liang, Deling Wang
      Preeclampsia, a disease mainly manifesting as serious hypertension during pregnancy, affects expectant mothers around the globe. Celastrol, a naturally existing triterpenoid, is known to exhibit beneficial effects attenuating cardiovascular symptoms including hypertension. We here assessed the treatment outcome against preeclampsia with a combined use of celastrol and nifedipine. 626 patients with preeclampsia were enrolled, screened, and assigned by random to groups receiving either nifedipine+placebo or nifedipine+celastrol orally. Time required to control hypertension as well as time before another hypertensive crisis were defined as primary endpoints. Secondary endpoints include the number of dosages required to control hypertension, as well as maternal and neonatal adverse effects. The time to control hypertension showed a marked reduction in nifedipine+celastrol group, while time before a new hypertensive crisis was significantly lengthened with the treatment, compared with the nifedipine+placebo group. The number of dosages required to control hypertension was also lower in the nifedipine+celastrol group. The two treatment groups were not statistically different regarding adverse effects, either maternal or neonatal. Results from the current study provides evidence for the potential role of celastrol serving as an effective and safe adjuvant to oral nifedipine against hypertension in patients with preeclampsia.

      PubDate: 2017-07-23T14:20:28Z
      DOI: 10.1016/j.jash.2017.07.004
       
  • No title
    • Authors: Daniel Levy
      Abstract: Publication date: Available online 17 July 2017
      Source:Journal of the American Society of Hypertension
      Author(s): Daniel Levy


      PubDate: 2017-07-23T14:20:28Z
       
  • Vitamin K2 Supplementation and Arterial Stiffness Among Renal Transplant
           Recipients – A Single-Arm, Single-Center Clinical Trial
    • Authors: Anthony Mansour; Essa Hariri; Yazan Daaboul; Serge Korjian; Andrew El Alam; Athanase D. Protogerou; Hala Kilany; Albert Karam; Antoine Stephan; Sola Aoun Bahous
      Abstract: Publication date: Available online 13 July 2017
      Source:Journal of the American Society of Hypertension
      Author(s): Anthony Mansour, Essa Hariri, Yazan Daaboul, Serge Korjian, Andrew El Alam, Athanase D. Protogerou, Hala Kilany, Albert Karam, Antoine Stephan, Sola Aoun Bahous
      Background Subclinical vitamin K deficiency is prevalent among renal transplant recipients and is associated with an increased risk of cardiovascular disease. However, the association between vitamin K supplementation and improvement of arterial stiffness has not been explored in the renal transplant population. Methods The KING trial (vitamin K2 In reNal Graft) is a single-arm study that evaluated the association between the change in vitamin K status and indices of arterial stiffness following 8 weeks of menaquinone-7 (vitamin K2) supplementation (360 μg once daily) among renal transplant recipients (n=60). Arterial stiffness was measured using carotid-femoral pulse wave velocity (cfPWV). Subclinical vitamin K deficiency was defined as plasma concentration of dephosphorylated-uncarboxylated Matrix Gla Protein (dp-ucMGP) > 500 pmol/L. Results At baseline, 53.3% of the study subjects had subclinical vitamin K deficiency. Supplementation was associated with a 14.2% reduction in mean cfPWV at 8 weeks (cfPWV pre-vitamin K2 = 9.8 ± 2.2 m/s vs. cfPWV post-vitamin K2 = 8.4 ± 1.5 m/s; p<0.001). Mean dp-ucMGP concentrations were also significantly reduced by 55.1% following menaquinone-7 supplementation with a reduction in the prevalence of subclinical deficiency by 40% (p=0.001). When controlled for age, durations of hemodialysis and transplantation, and the change in 24-hour mean arterial pressure, the improvement in arterial stiffness was independently associated with the reduction in dp-ucMGP concentration (p=0.014). Conclusions Among renal transplant recipients with stable graft function, vitamin K2 supplementation was associated with improvement in subclinical vitamin K deficiency and arterial stiffness. (Clinicaltrials.gov: NCT02517580).

      PubDate: 2017-07-23T14:20:28Z
      DOI: 10.1016/j.jash.2017.07.001
       
  • Inter-arm blood pressure difference in a post stroke population
    • Authors: E. Gaynor; L. Brewer; L. Mellon; P. Hall; N.F. Horgan; E. Shelley; E. Dolan; A. Hickey; K. Bennett; D.J. Williams
      Abstract: Publication date: Available online 4 July 2017
      Source:Journal of the American Society of Hypertension
      Author(s): E. Gaynor, L. Brewer, L. Mellon, P. Hall, N.F. Horgan, E. Shelley, E. Dolan, A. Hickey, K. Bennett, D.J. Williams
      Background An increased inter-arm systolic blood pressure difference of >10mmHg is associated with increased cardiovascular risk and a difference of >15mmHg with increased cerebrovascular risk. The stroke population presents a high-risk group for future cardiovascular and cerebrovascular events and therefore estimation of inter-arm SBP difference as a predictive tool may assist with further secondary stroke prevention. Objective To determine the prevalence of inter-arm systolic and diastolic blood pressure difference in a post stroke population. Methods A comprehensive assessment of secondary risk factors along with blood pressure measurements were taken 6-months’ post ischaemic stroke from the ASPIRE-S (Action on Secondary Prevention Interventions and Rehabilitation in Stroke cohort). Descriptive and logistic regression analyses were performed. Odds ratios and 95% Confidence intervals are presented Results 238 (M: F,139:99, mean age 68.4yrs) of 256 patients followed up at 6 months post stroke had suitable BP readings from both arms.40.3% (n=96) had an inter-arm systolic blood pressure difference of >10mmHg and 20.6% (n=49) had a difference of >15mmHg. A history of hypertension, diabetes, smoking and obesity was not significantly associated with an increased risk of inter-arm systolic blood pressure difference. After multivariate logistic analysis, a history of alcohol excess was associated with an increased IASBP >15mmHg (OR 2.32, 95% CI 1.03-5.22). Conclusion We have demonstrated that inter-arm systolic blood pressure difference is commonly seen in a post stroke population.

      PubDate: 2017-07-12T11:23:12Z
      DOI: 10.1016/j.jash.2017.06.008
       
  • Soluble endoglin (sEng) as a prognostic factor of the claudication
           distance improvement in patients with peripheral artery disease (PAD)
           undergoing supervised treadmill training program (STTP)
    • Authors: Rafał Januszek; Piotr Mika; Roman Nowobilski; Witold Nowak; Anna Kusienicka; Damian Klóska; Paweł Maga; Rafał Niżankowski
      Abstract: Publication date: Available online 28 June 2017
      Source:Journal of the American Society of Hypertension
      Author(s): Rafał Januszek, Piotr Mika, Roman Nowobilski, Witold Nowak, Anna Kusienicka, Damian Klóska, Paweł Maga, Rafał Niżankowski
      Conservative therapy after complete revascularization is increasing in popularity in patients with peripheral artery disease (PAD). The aim of the current study was to find determinants of the improvement of walking abilities and endothelial function in patients with PAD undergoing supervised treadmill training program (STTP). The presented study enclosed 66 patients in the mean age 65.4 ± 7.7 years with PAD who underwent a 3-month length STTP. We assessed the effect of following factors on the change of the flow-mediated dilatation value (ΔFMD), maximal-walking time (ΔMWT) and pain-free walking time (ΔPFWT). The evaluation included several biochemical and anthropometric indices with special insight into markers of angiogenesis, including soluble-endoglin (sEng), platelet-derived growth factor and angiopietin-2. Linear regression analysis (LRA) for each of the variables and multi-factorial model analysis of variances (ANOVA) was adopted to select the most influential determinants. The levels of sEng, a biomarker of several cardiovascular pathologies, were found to significantly predict the greater improvement of MWT and PFWT. Moreover, the LRA demonstrated, and ANOVA confirmed that coronary artery disease (CAD) and peracted endovascular interventions of lower limbs arteries (LLAs) are significant determinants of the better ΔFMD improvement. On the contrary, treatment with β-blockers and older age were poor predictors of ΔFMD increase. In conclusion, the sEng level could serve as a determinant of walking abilities change after STTP in patients with PAD. The treatment with β-blockers, the coexistence of CAD and peracted endovascular interventions of LLAs are determinants of endothelial function.

      PubDate: 2017-07-03T10:26:53Z
      DOI: 10.1016/j.jash.2017.06.009
       
  • White coat effect in hypertensive patients: the role of hospital
           environment or physician presence
    • Authors: Xi-xing Wang; Wei Shuai; Qiang Peng; Ju-xiang Li; Ping Li; Xiao-shu Cheng; Hai Su
      Abstract: Publication date: Available online 21 June 2017
      Source:Journal of the American Society of Hypertension
      Author(s): Xi-xing Wang, Wei Shuai, Qiang Peng, Ju-xiang Li, Ping Li, Xiao-shu Cheng, Hai Su
      Subject This study was to evaluate the role of hospital environment or physician presence for white coat effect (WCE) in hypertensive patients. Methods At first, 54 hypertensive outpatients diagnosed on office blood pressure (BP) were included for 2-week placebo run in. During the second week of the run in period, home BP (HBP) was measured using electronic BP monitors for 5-7 days. Finally, 26 sustained hypertensive patients with home SBP/DBP over 135/85 (but less than 180/110) mmHg were enrolled for 8-week treatment of nifedipine controlled-release tablet. In the visit day, BP was measured by patient-self (OBP-p) or by doctor (OBP-d) according to order determined with randomization method. The self BP measurement was performed in a reception room of hospital. The differences between HBP and OBP-d or OBP-p were calculated as WCE-d or WCE-p, respectively. The home and office BP were measured with the same BP device for each patient during the study period. Results In the total 54 outpatients received placebo, the WCE-d was similar to the WCE-p (for SBP 6.6±14.4 vs 6.8±15.8 mmHg, NS; for DBP 3.3±8.8 vs 2.9±9.2 mmHg, NS). Meanwhile, the 26 sustained hypertensive patients had similar systolic WCE-d and WCE-p (4.8±10.3 vs 5.0±12.2 mmHg, NS) at placebo stage. Similarly, these values were comparable (3.0±14.0 vs 2.2±14.4mmHg, NS) in treatment stage. Conclusion Hospital environment plays a main role for the white coat effect in hypertensive patients.

      PubDate: 2017-06-22T08:07:42Z
      DOI: 10.1016/j.jash.2017.06.006
       
  • Visit-to-Visit Variability of Blood Pressure
    • Authors: John B. Kostis
      Abstract: Publication date: Available online 20 June 2017
      Source:Journal of the American Society of Hypertension
      Author(s): John B. Kostis


      PubDate: 2017-06-22T08:07:42Z
      DOI: 10.1016/j.jash.2017.06.005
       
  • Instructions for Authors
    • Abstract: Publication date: June 2017
      Source:Journal of the American Society of Hypertension, Volume 11, Issue 6


      PubDate: 2017-06-22T08:07:42Z
       
  • Systemic and tissue-specific effects of aliskiren on the RAAS and
           carbohydrate/lipid metabolism in obese patients with hypertension
    • Authors: Stefan Engeli; Marcus May; Juerg Nussberger; A. H. Jan Danser; William P. Dole; Margaret F. Prescott; Marion Dahlke; Sylvie Stitah; Parasar Pal; Michael Boschmann; Jens Jordan
      Abstract: Publication date: Available online 12 June 2017
      Source:Journal of the American Society of Hypertension
      Author(s): Stefan Engeli, Marcus May, Juerg Nussberger, A. H. Jan Danser, William P. Dole, Margaret F. Prescott, Marion Dahlke, Sylvie Stitah, Parasar Pal, Michael Boschmann, Jens Jordan
      Aliskiren penetrates adipose and skeletal muscle in hypertensive patients with abdominal obesity and reduces renin-angiotensin-aldosterone system activity. After discontinuation, blood-pressure–lowering effects are observed possibly through drug–tissue binding. We performed microdialysis evaluation of adipose tissue and skeletal muscle before and during an insulin-modified frequently sampled intravenous glucose tolerance test (IM-FSIGT). Aliskiren 300 mg (n=8) or amlodipine 5 mg (n=8) once daily were administered during a 12-week randomized treatment period. Aliskiren elicited variable changes in median interstitial angiotensin II in adipose (2.60 to 1.30 fmol/mL) and skeletal muscle (2.23 to 0.68 fmol/mL); amlodipine tended to increase adipose and skeletal muscle angiotensin II (p=0.066 for skeletal muscle treatment difference). Glucose/insulin increased median plasma angiotensin II 1 hour after glucose injection (1.04 to 2.50 fmol/mL; p=0.001), which was markedly attenuated by aliskiren but not amlodipine. Aliskiren increased glucose disposition index (p=0.012) and tended to increase acute insulin response to glucose (p=0.067). Fasting adipose glycerol (−17%; p=0.064) and fasting muscle glucose dialysate (−17%; p=0.025) were decreased by aliskiren but not amlodipine. In summary, aliskiren decreased angiotensin II production in response to glucose/insulin stimulus and elicited metabolic effects in adipose and skeletal muscle suggestive of increased whole-body glucose utilization.

      PubDate: 2017-06-16T07:37:07Z
      DOI: 10.1016/j.jash.2017.06.002
       
  • The Effect of Circadian Blood Pressure Pattern on Presence of Fragmented
           QRS Complexes in Hypertensive Subjects
    • Authors: Mehmet Eyuboglu; Yavuz Karabag; Suleyman Karakoyun; Bahri Akdeniz
      Abstract: Publication date: Available online 12 June 2017
      Source:Journal of the American Society of Hypertension
      Author(s): Mehmet Eyuboglu, Yavuz Karabag, Suleyman Karakoyun, Bahri Akdeniz
      The association of deteriorated circadian blood pressure (BP) variability with presence of fragmented QRS (fQRS) on electrocardiography (ECG) is not clear. The present study aims to evaluate the relationship of BP patterns with presence of fQRS on ECG. 338 consecutive newly diagnosed and never treated hypertensive patients who are without left ventricular hypertrophy (LVH) and underwent 24-h ambulatory blood pressure monitoring (ABPM) were enrolled. Patients were classified as dippers, nondippers and reverse dippers according to ABPM results. The groups were compared regarding frequency of fQRS on ECG. The frequency of fQRS was significantly higher in reverse dippers compared to dippers (%37,7 vs %20,6, p=0,013). In multivariate logistic regression analysis, nighttime systolic BP was found to be an independent predictor of fQRS on ECG (p<0,001, 95% CI=0,901-0,955). Other predictors of fQRS were daytime diastolic BP and age. Furthermore, fQRS was found to be an independent predictor of reverse dipping BP pattern in hypertensive patients (p=0,004, OR: 2,416, 95% CI=1,327-4,396). In conclusion, as a marker of fibrosis and higher fibrotic burden within myocardium, fQRS may be useful to determine the high risk hypertensive patients in the absence of LVH.

      PubDate: 2017-06-16T07:37:07Z
      DOI: 10.1016/j.jash.2017.06.001
       
  • Large geographic disparity in life expectancy may be driven by rates of
           hypertension and related metabolic and behavioral parameters
    • Authors: Michael J. Bloch
      Abstract: Publication date: Available online 8 June 2017
      Source:Journal of the American Society of Hypertension
      Author(s): Michael J. Bloch


      PubDate: 2017-06-12T07:11:50Z
      DOI: 10.1016/j.jash.2017.05.004
       
  • Severe and Resistant Hypertension in an Older Woman with Claudication
    • Authors: Puneet Gupta; Robert Hagberg; Electra Kaloudis; Anika Lucas; Parth Shah; William B. White
      Abstract: Publication date: Available online 1 June 2017
      Source:Journal of the American Society of Hypertension
      Author(s): Puneet Gupta, Robert Hagberg, Electra Kaloudis, Anika Lucas, Parth Shah, William B. White
      Coarctation of the aorta is an uncommon cause of treatment resistant hypertension in adults. It is typically detected and treated in infancy or childhood with surgical or endovascular procedures. Most cases of recurrence of coarctation after repair occur in childhood or early adulthood; recurrence in older persons (> 70 years) has rarely been reported. A 73 year old woman was referred to us for the management of treatment resistant hypertension accompanied by symptoms of claudication and headaches, which had resulted in multiple emergency room visits. Of note, 58 years earlier, a graft from the left subclavian artery had been used to bypass an aortic coarctation. During a hospitalization for severe hypertension accompanied by acute kidney injury and heart failure, diagnostic angiography revealed a complete thrombotic occlusion of the left subclavian artery-to-descending aorta bypass graft and a tight coarctation in the descending thoracic aorta. Balloon angioplasty and stenting across the coarctation was only transiently effective; subsequently an ascending-to-descending graft was placed distal to the coarctation and within a few days, the blood pressure levels and claudication improved markedly. This case demonstrates that hypertension specialists should suspect the possibility of recurrence of a coarctation in older patients who present with resistant hypertension and have a remote history of coarctation repair. Although such late recurrences are not common, as illustrated in our patient, surgical intervention may contribute to significant improvement in blood pressure control and prevent future complications.

      PubDate: 2017-06-02T05:37:49Z
      DOI: 10.1016/j.jash.2017.05.007
       
  • Predictors of visit-to-visit blood pressure variability in patients with
           hypertension: an analysis of trials with an amlodipine treatment arm
    • Authors: Ji-Guang Wang; Duo Zhou; Barrett W. Jeffers
      Abstract: Publication date: Available online 29 May 2017
      Source:Journal of the American Society of Hypertension
      Author(s): Ji-Guang Wang, Duo Zhou, Barrett W. Jeffers
      We conducted a post hoc analysis of blood pressure (BP) data from long-term antihypertensive trials in order to identify predictors of visit-to-visit blood pressure variability (BPV). BPV was defined as the within-subject coefficient of variation in systolic BP (SBP) from week 12 onwards. BP data from the ASCOT-BPLA, ALLHAT, CAMELOT, NY92011, and R-0510 trials were pooled and dichotomized into top 25th and bottom 75th percentiles due to positive skew. Significant (P<0.001) predictors of BPV within the top 25th percentile were identified using logistic regression. The baseline characteristics of the pooled cohort (n=47,558) were similar between patients who received amlodipine (n=17,499) versus other antihypertensive drugs (n=29,491). BPV in the top 25th percentile was lower with amlodipine versus other treatments (13.7±3.2 versus 14.3±3.5), with single-study analyses of ASCOT-BPLA, ALLHAT, and CAMELOT all showing BPV was lowest with amlodipine. Baseline diastolic blood pressure (DBP), eGFR, and smoking were predictors of BPV, with significant two-way interactions between smoking and both age and body mass index, and between SBP or DBP and being randomized to treatment other than amlodipine. In conclusion, analysis of BPV required transformation of BP data. Following transformation, a number of baseline variables and combinations of variables were predictors of BPV.

      PubDate: 2017-06-02T05:37:49Z
      DOI: 10.1016/j.jash.2017.05.006
       
  • Pharmacokinetic, Pharmacodynamic, and Antihypertensive Effects of the
           Neprilysin Inhibitor LCZ-696: Sacubitril/Valsartan
    • Authors: Steven G. Chrysant
      Abstract: Publication date: Available online 25 May 2017
      Source:Journal of the American Society of Hypertension
      Author(s): Steven G. Chrysant
      LCZ-696: sacubitril/Valsartan is a dual-acting molecule consisting of the angiotensin II (Ang II) receptor blocker (ARB) valsartan and the neprisylin (neutral endopeptidase, NEP) inhibitor AHU-377 with significant beneficial effects in patients with hypertension and heart failure (HF). Several recent studies have demonstrated a higher effectiveness of LCZ-696 compared to valsartan in the treatment of hypertension and HF. The rationale for the development and the Food and Drug Administration (FDA) approval of LCZ-696 was based on the concept of an additive effect of the angiotensin II receptor blocker valsartan and the NEP (neprilysin) inhibitor AHU-377 for the treatment of hypertension and HF. The synergism from these drugs arises from the vasodilating effects of valsartan through its blockade of Ang II AT1 receptor and the action of natriuretic peptides ANP and BNP by preventing their catabolism with neprilysin resulting in increase of cyclic GMP. This action of neprilysin is associated with increased natriuresis, diuresis and systemic vasodilation, since these peptides have been shown to have potent diuretic, natriuretic and vasodilating effects. In addition, it reduces the levels of NT-Pro BNP. Therefore, administration of LCZ-696 results in significant reduction of wall stress from pressure and volume overload of the left ventricle as demonstrated by the reduction of NT-ProBNP, both significant constituents of hypertension and HF, and it is safe, well tolerated and is almost free of cough and angioedema

      PubDate: 2017-05-28T05:03:01Z
      DOI: 10.1016/j.jash.2017.04.012
       
  • Race and Sex Differences in Ambulatory Blood Pressure Measures among HIV+
           Adults
    • Authors: Shia T. Kent; Joseph E. Schwartz; Daichi Shimbo; Edgar T. Overton; Greer A. Burkholder; Suzanne Oparil; Michael J. Mugavero; Paul Muntner
      Abstract: Publication date: Available online 25 May 2017
      Source:Journal of the American Society of Hypertension
      Author(s): Shia T. Kent, Joseph E. Schwartz, Daichi Shimbo, Edgar T. Overton, Greer A. Burkholder, Suzanne Oparil, Michael J. Mugavero, Paul Muntner
      Ambulatory blood pressure monitoring (ABPM) can identify phenotypes that cannot be measured in the clinic. Determining race and sex disparities in ABPM measures among HIV+ individuals may improve strategies to diagnose and treat hypertension in this high risk population. We compared ABPM measures between 24 African American and 25 white HIV+ adults (36 men and 13 women). Awake systolic BP (SBP) and diastolic BP (DBP) were similar in African Americans and whites. After multivariable adjustment, sleep SBP and DBP were 9.7 (95%confidence interval [95%CI]: 4.7, 14.8) mmHg and 8.4 (95%CI: 4.3, 12.5) mmHg higher, respectively, among African Americans compared with whites. After multivariable adjustment, SBP and DBP dipping ratios were 5.2% (95%CI: 1.7%, 8.7%) and 6.1% (95%CI 2.0%, 10.3%) smaller among African Americans compared with whites. After multivariable adjustment, awake and sleep SBP and DBP were higher in men compared to women. There was no difference in SBP or DBP dipping ratios comparing men and women. The prevalence of awake masked hypertension was 42% in men versus 17% in women, and the prevalence of sleep masked hypertension was 57% among African Americans versus 18% among whites. These data suggest that ABPM measures differ by race and sex in HIV+ adults.

      PubDate: 2017-05-28T05:03:01Z
      DOI: 10.1016/j.jash.2017.05.002
       
  • Serum metabolomic response to exercise training in spontaneously
           hypertensive rats
    • Authors: Xiangyang Liu; Yanjun Wang; Rui Gao; Ying Xing; Xiaomiao Li; Zhengjun Wang
      Abstract: Publication date: Available online 20 May 2017
      Source:Journal of the American Society of Hypertension
      Author(s): Xiangyang Liu, Yanjun Wang, Rui Gao, Ying Xing, Xiaomiao Li, Zhengjun Wang
      Chronic aerobic exercise training exhibits blood pressure protective effects, but the mechanism in metabolic level remains largely unclear. This study aims to investigate the effect of exercise training from serum metabolic profiles on the development of hypertension in spontaneously hypertensive rats (SHR). Exercise training was performed, and the serum metabolites were measured by integrating gas chromatography-mass spectrometer and correlation-based network analysis. After a period of 6 weeks of chronic aerobic exercise training, systolic blood pressure was significant lower in the exercise training group (SHR+EX) rats than the control group (SHR). Principal component analysis indicated a clearly separation of metabolomic profiles between SHR+EX and SHR. Nineteen of 63 metabolites in serum were identified (p < 0.05, variable importance in projections > 1, false discovery rate < 0.1), including fatty acids, amino acids and others. Lower levels of 6 fatty acids were observed in SHR+EX. Besides, pathway analysis indicated a significant alteration of fatty acid metabolism. The correlation-based (Pearson correlation coefficient > 0.83) network of serum metabolites revealed a decreased correlation linkage of SHR+EX than SHR rats. Higher activities of hexokinase, citrate synthase, aspartate aminotransferase and alanine aminotransferase were detected in liver, left ventricle, and skeletal muscle of SHR+EX groups. In summary, these findings provided essential biochemistry information about the metabolic alteration to exercise training in SHR, which may in part explained the protective effect of exercise in hypertensive individuals.

      PubDate: 2017-05-23T04:13:43Z
      DOI: 10.1016/j.jash.2017.05.003
       
  • The Dietary Approaches to Stop Hypertension (DASH) diet—Promise
           Unmet
    • Authors: Michael J. Bloch
      Abstract: Publication date: Available online 20 May 2017
      Source:Journal of the American Society of Hypertension
      Author(s): Michael J. Bloch


      PubDate: 2017-05-23T04:13:43Z
      DOI: 10.1016/j.jash.2017.04.011
       
  • Prevalence, Awareness, Treatment and Control of Hypertension in Older
           People in Central Africa: The Epidemca Study
    • Authors: Sophie Pilleron; Victor Aboyans; Pascal Mbelesso; Bébène Ndamba-Bandzouzi; Ileana Desormais; Philippe Lacroix; Pierre-Marie Preux; Maëlenn Guerchet; Maëlenn Guerchet; Bébène Ndamba-Bandzouzi; Pascal Mbelesso; Sophie Pilleron; Iléana Desormais; Philippe Lacroix; Victor Aboyans; Jean-Claude Desport; Pierre Jésus; Achille E. Tchalla; Benoît Marin; Jean-Pierre Clément; Jean-Charles Lambert; Jean-François Dartigues; Pierre-Marie Preux
      Abstract: Publication date: Available online 9 May 2017
      Source:Journal of the American Society of Hypertension
      Author(s): Sophie Pilleron, Victor Aboyans, Pascal Mbelesso, Bébène Ndamba-Bandzouzi, Ileana Desormais, Philippe Lacroix, Pierre-Marie Preux, Maëlenn Guerchet
      Hypertension represents a major global health burden. While older individuals of African descent are at higher risk of hypertension in western countries, epidemiological data on hypertension in older native Africans are scarce. We assessed the prevalence and the level of awareness and control of hypertension among older adults in Central Africa. A total of 1990 individuals 65 years of age and older from the Republic of Congo and the Central African Republic participated into a cross-sectional population-based survey. Hypertension was defined by self-reporting of on-going treatment and/or systolic (SBP)/diastolic (DBP) blood pressures at rest being ≥140 and/or 90 mmHg. Controlled hypertension was defined as treated hypertension with SBP <140 mmHg and DBP <90 mmHg. The overall prevalence of hypertension was 61.1%. Among hypertensive people, 46.7% were aware of their condition and 17.3% were treated. Among the latter 23.8% had their hypertension controlled. Correlates of hypertension were increasing age and body mass index, living in the Republic of Congo, occupation other than employee, no tobacco use, sedentary lifestyle and ≥ 3 meals a day. Our findings indicate a need for the implementation of public health policies to reduce hypertension in older Africans, and to prevent the subsequent burden of cardiovascular diseases.

      PubDate: 2017-05-13T02:32:06Z
      DOI: 10.1016/j.jash.2017.04.013
       
  • Speckle tracking echocardiography and tissue Doppler imaging reveal
           beneficial effect of pharmacotherapy in hypertensives with asymptomatic
           left ventricular dysfunction
    • Authors: Beata Uziębło-Życzkowska; Paweł Krzesiński; Grzegorz Gielerak; Andrzej Skrobowski
      Abstract: Publication date: Available online 8 May 2017
      Source:Journal of the American Society of Hypertension
      Author(s): Beata Uziębło-Życzkowska, Paweł Krzesiński, Grzegorz Gielerak, Andrzej Skrobowski
      Global longitudinal strain (GLS), assessed by speckle tracking echocardiography (STE), is a sensitive marker of myocardial systolic function and an independent predictor of cardiovascular outcomes. The aim of this study was to investigate the effect of hypotensive treatment on GLS and evaluate the relation between change in GLS and left ventricular (LV) diastolic function. Methods In a group of 125 hypertensive subjects, without any symptoms of heart failure, the detailed echocardiographic assessment of LV systolic and diastolic function was performed prior to and after 12 months of hypotensive treatment. Results The mean GLS improved from -18.1±2.6% to -19.3±2.3% (p=0.004). Positive change was also observed within parameters of LV diastolic function (E/A: 1.05±0.32 vs 1.15±0.34; p=0,008; e': 9.54±2.60cm/s vs 10.59±2.39cm/s; p=0.003; E/e': 7.35±1.85 vs 6.69±1.61; p=0.044). The greatest benefit from hypotensive treatment was noticed within the patients with the lowest baseline absolute values of GLS. The significant correlations between change in GLS and e' (r=-0.51; p<0.001) as well as GLS and E/e' ratio (0.23; p=0.022) were also observed. Conclusions Mild systolic and diastolic LV alterations are interdependent and partially reversible. The effects of hypotensive therapy are differentiated in particular individuals and those with more impaired LV function seem to benefit most.

      PubDate: 2017-05-13T02:32:06Z
      DOI: 10.1016/j.jash.2017.03.009
       
  • The Relation of Digital Vascular Function to Cardiovascular Risk Factors
           in African Americans Using Digital Tonometry: the Jackson Heart Study
    • Authors: Eric E. McClendon; Solomon K. Musani; Tandaw E. Samdarshi; Sushant Khaire; Donny Stokes; Naomi M. Hamburg; Koby Sheffy; Gary F. Mitchell; Herman R. Taylor; Emelia J. Benjamin; Ervin R. Fox
      Abstract: Publication date: Available online 4 May 2017
      Source:Journal of the American Society of Hypertension
      Author(s): Eric E. McClendon, Solomon K. Musani, Tandaw E. Samdarshi, Sushant Khaire, Donny Stokes, Naomi M. Hamburg, Koby Sheffy, Gary F. Mitchell, Herman R. Taylor, Emelia J. Benjamin, Ervin R. Fox
      Digital vascular tone and function, as measured by peripheral arterial tonometry (PAT), are associated with cardiovascular risk and events in non-Hispanics whites. There are limited data on relations between PAT and cardiovascular risk in African Americans. PAT was performed on a subset of Jackson Heart Study participants using a fingertip tonometry device. Resting digital vascular tone was assessed as baseline pulse amplitude. Hyperemic vascular response to 5-minutes of ischemia was expressed as the PAT ratio (hyperemic/baseline amplitude ratio). Peripheral augmentation index, a measure of relative wave reflection, also was estimated. The association of baseline PA, PAT ratio and augmentation index to risk factors was assessed using stepwise multivariable models. The study sample consisted of 837 participants from the Jackson Heart Study (mean age, 54±11 years, 61% women). In stepwise multivariable regression models, baseline pulse amplitude was related to male sex, body mass index and diastolic BP, accounting for 16% of the total variability of the baseline pulse amplitude. Age, male sex, systolic BP, diastolic BP, antihypertensive medication, and prevalent CVD contributed to 11% of the total variability of the PAT ratio. Risk factors (primarily age, sex and heart rate) explained 47% of the total variability of the augmentation index. We confirmed in our cohort of African Americans, a significant relation between digital vascular tone and function measured by PAT and multiple traditional cardiovascular risk factors. Further studies are warranted to investigate the utility of these measurements in predicting clinical outcomes in African Americans.

      PubDate: 2017-05-08T01:09:17Z
      DOI: 10.1016/j.jash.2017.04.008
       
  • Elastin microfibril interface located protein (EMILIN)1, Transforming
           growth factor beta (TGFβ), and Implications on Cardiovascular
           Complications
    • Authors: Amy Randell; Noriko Daneshtalab
      Abstract: Publication date: Available online 3 May 2017
      Source:Journal of the American Society of Hypertension
      Author(s): Amy Randell, Noriko Daneshtalab
      Elastin microfibril interface located protein (EMILIN), a glycoprotein, is associated with elastin in the extracellular matrix (ECM) of arteries, lymph vasculature and other tissues. EMILIN1 particularly has a niche role in elastin fiber biogenesis (elastogenesis) by aiding with the fusion of elastin fibers, rendering them more ordered. In addition to elastogenesis, EMILIN1 has been shown to have roles in maintenance of vascular cell morphology, smooth muscle cell (SMC) adhesion to elastic fibers, and transforming growth factor (TGFβ) regulation, by inhibiting TGFβ activation via blocking the proteolytic production of the latency associated peptide/active TGFβ complex. The increased TGFβ signaling induced during EMILIN1 deficiency alters TGFβ activity, resulting in vascular SMC growth and vascular remodeling. The increasing systemic blood pressure associated with TGFβ signaling may be closely linked to the activity of other mediators that affect cardiovascular homeostasis, such as angiotensin II. The increase in prevalence of hypertension and other cardiovascular diseases in other disease states likely involve a complex activation of TGFβ signaling, and ECM dysfunction. Thus, the interaction of TGFβ and ECM components appears to be integrative involving both structural alterations to vessels through EMILIN1 and changes in TGFβ signaling processes. This review summarizes the current knowledge on the EMILIN1 –TGFβ relationship; the specific roles of EMILIN1 and TGFβ in blood pressure regulation, their synergistic interaction, and in particular the role of TGFβ (in conjunction with ECM proteins) in other disease states altering cardiovascular homeostasis.

      PubDate: 2017-05-08T01:09:17Z
      DOI: 10.1016/j.jash.2017.04.010
       
  • Relationship among Age, Insulin Resistance, and Blood Pressure
    • Authors: Chan-Hee Jung; Sang Hee Jung; Bora Lee; Melanie Rosenberg; Gerald M. Reaven; Sun H. Kim
      Abstract: Publication date: Available online 14 April 2017
      Source:Journal of the American Society of Hypertension
      Author(s): Chan-Hee Jung, Sang Hee Jung, Bora Lee, Melanie Rosenberg, Gerald M. Reaven, Sun H. Kim
      The effect of age to modify the relationship between insulin resistance and hypertension are unclear. In this retrospective, cross-sectional study, median age was used to create two age groups (<52 vs. ≥52 years), and comparisons were made of metabolic characteristics, including steady-state plasma glucose (SSPG) concentrations measured during the insulin suppression test to quantify insulin resistance. Individuals were stratified into SSPG tertiles and categorized as having normal BP, prehypertension, or hypertension. SSPG concentrations were similar in the two age groups (161 vs. 164 mg/dL). In the most insulin resistant tertile, distribution of normal BP, prehypertension, and hypertension was equal in those <52 years, whereas in those ≥52 years, prevalence of hypertension was increased approximately five-fold as compared to those with normal BP. Multivariate regression analysis demonstrated significant interaction between age and SSPG in predicting systolic BP (p=0.023). In stratified analysis, SSPG, but not age, was an independent predictor of systolic BP and diastolic BP in ≥52 year group, whereas the reverse was true in the younger group. The adverse impact of insulin resistance on blood pressure was accentuated in older individuals and may have a greater impact than further aging.

      PubDate: 2017-04-18T22:01:34Z
      DOI: 10.1016/j.jash.2017.04.005
       
  • Smoking before isometric exercise amplifies myocardial stress and
           dysregulates baroreceptor sensitivity and cerebral oxygenation
    • Authors: Panagiota Anyfanti; Eleftheria Triantafyllidou; Stavros Papadopoulos; Areti Triantafyllou; Michalis G. Nikolaidis; Antonis Kyparos; Ioannis S. Vrabas; Stella Douma; Andreas Zafeiridis; Konstantina Dipla
      Abstract: Publication date: Available online 14 April 2017
      Source:Journal of the American Society of Hypertension
      Author(s): Panagiota Anyfanti, Eleftheria Triantafyllidou, Stavros Papadopoulos, Areti Triantafyllou, Michalis G. Nikolaidis, Antonis Kyparos, Ioannis S. Vrabas, Stella Douma, Andreas Zafeiridis, Konstantina Dipla
      This cross-over study examined whether acute cardiovascular responses, baroreceptor sensitivity (BRS), and brain oxygenation during isometric exercise are altered following cigarette smoking. Twelve young, habitual smokers randomly performed a smoking and a control protocol, during which participants smoked one cigarette (0.9mg nicotine) or a sham-cigarette, prior to exercise. Testing involved baseline, a 5-min smoking, a 10-min post-smoking rest, 3 min handgrip-exercise (30% maximum voluntary-contraction), and recovery. Beat-to-beat blood pressure (BP), heart rate (HR), and cerebral oxygenation (Near-Infrared-Spectroscopy, NIRS) were continuously monitored. Double-product, stroke volume (SV), cardiac output, systemic vascular resistance (SVR) and BRS were assessed. During post-smoking rest, systolic/diastolic BP (140.8±12.1/87.0±6.9 vs. 125.9±7.1/77.3±5.5mmHg), HR, and double-product were higher in the smoking vs. the control protocol, whereas BRS was lower (p<0.05). During handgrip-exercise, smoking resulted in greater HR and double-product (17240±3893 vs. 15424±3173mmHg·bpm) and lower BRS vs. the control protocol (p<0.05), without significant differences in SV and SVR between protocols. During recovery, smoking elicited a delayed return of brain-oxygenation indices, lower BRS, and higher double-product. Smoking a cigarette shortly before the exercise session, amplifies myocardial stress and dysregulates autonomic function and cerebral oxygenation during exercise and recovery, even in young habitual smokers, perceived as free from long-term cardiovascular effects of smoking.
      Graphical abstract image

      PubDate: 2017-04-18T22:01:34Z
      DOI: 10.1016/j.jash.2017.04.004
       
  • Salt and Essential Hypertension: Pathophysiology and Implications for
           Treatment
    • Authors: Michael A. Garfinkle
      Abstract: Publication date: Available online 14 April 2017
      Source:Journal of the American Society of Hypertension
      Author(s): Michael A. Garfinkle
      Essential hypertension is common and is associated with significant morbidity and mortality. However, questions remain as to the exact physiologic mechanisms underlying this disease. First, we discuss how essential hypertension may be largely a result of a maladaptation to a high salt diet and that high blood pressure, rather than being an inactive side effect of high salt intake, may be an adaptive mechanism to improve salt secretion. Next we explain how any physiologic state that reduces urinary sodium concentrating ability may increase an individual’s risk for salt-induced hypertension. Finally, we conclude that natriuresis is a crucial criterion for effective long-term pharmacologic treatment of essential hypertension.

      PubDate: 2017-04-18T22:01:34Z
      DOI: 10.1016/j.jash.2017.04.006
       
  • The Number of Visits and Blood Pressure Measurements Influence the
           Prevalence of High Blood Pressure in Adolescents
    • Authors: Luciano Machado Ferreira Tenório de Oliveira; Alison Oliveira da Silva; Paula Rejane Beserra Diniz; Breno Quintella Farah; André Luiz Torres Pirauá; Antônio José de Lima Neto; Wallacy Milton do Nascimento Feitosa; Rafael Miranda Tassitano; Raphael M. Ritti-Dias
      Abstract: Publication date: Available online 13 April 2017
      Source:Journal of the American Society of Hypertension
      Author(s): Luciano Machado Ferreira Tenório de Oliveira, Alison Oliveira da Silva, Paula Rejane Beserra Diniz, Breno Quintella Farah, André Luiz Torres Pirauá, Antônio José de Lima Neto, Wallacy Milton do Nascimento Feitosa, Rafael Miranda Tassitano, Raphael M. Ritti-Dias
      Background The aim of this study was to analyze the influence of the number of visits and the number of blood pressure (BP) measurements on the prevalence of high blood pressure (HBP) in adolescents. Methods A cross-sectional epidemiological study with 481 adolescents (14 to 19 years old) selected using a random cluster sampling strategy. We measured the BP three times in a first visit. Adolescents with HBP performed subsequent visits. The final calculation of BP followed four strategies: the 1st measure, mean of 1st and 2nd measurements, mean of all three measurements and averaging the 2nd and 3rd measurement. Results The prevalence of HBP in the first and second visits were 6.4%, 1.9% and the prevalence of hypertension (after three visits) was 1.7%. The prevalence of HBP varied from 8.6% to 18.6% for boys and 4.6% to 9.2% for girls, using the average 2nd and 3rd measurements and the 1st measurement, respectively. In all strategies, HBP and hypertension were more prevalent in boys and students attending the nocturnal shift. Conclusion The number of visits and number of measurements affects the prevalence of HBP and hypertension in adolescents. Thus, clinicians and researchers should consider these aspects when assessing BP in adolescents aged 14 to 19 years old.

      PubDate: 2017-04-18T22:01:34Z
      DOI: 10.1016/j.jash.2017.04.002
       
  • Aortic Backward Waves Rather Than Stiffness Account for Independent
           Associations Between Pulse Pressure Amplification and Left Ventricular
           Mass in a Young-to-Middle Aged Sample
    • Authors: Moekanyi J. Sibiya; Gavin R. Norton; Hendrik L. Booysen; Grace Tade; Carlos D. Libhaber; Imraan Ballim; Pinhas Sareli; Angela J. Woodiwiss
      Abstract: Publication date: Available online 13 April 2017
      Source:Journal of the American Society of Hypertension
      Author(s): Moekanyi J. Sibiya, Gavin R. Norton, Hendrik L. Booysen, Grace Tade, Carlos D. Libhaber, Imraan Ballim, Pinhas Sareli, Angela J. Woodiwiss
      A decreased aortic-to-brachial pulse pressure amplification (PP amplification), which is independently associated with cardiovascular outcomes, may index several aortic functional changes. However that aortic functional change most likely to account for this effect is uncertain. In 706 randomly selected community participants of African ancestry with a mean age of 44.4±18.2 years we assessed aortic function using radial applanation tonometry and SphygmoCor software (including forward [Pf] and backward [Pb] wave separation analysis assuming a triangular flow waveform) and left ventricular mass index (LVMI)(echocardiography). In multivariate models with the inclusion of brachial PP, 1/PP amplification (partial r=0.12, p<0.005), reflected wave pressures (partial r=0,09, p<0.05), and aortic pulse wave velocity (PWV) (partial r=0.09, p<0.05) were independently associated with LVMI. Similarly, in multivariate models with the inclusion of brachial PP, 1/PP amplification (p<0.005), the reflected wave pressure (p<0.01), and aortic PWV (p<0.01) were independently associated with LVH. With adjustments for reflected wave pressures, the brachial PP-independent relationships between 1/PP amplification and LVMI or LVH were abolished (p>0.08 for both). However, adjustments for PWV failed to modify brachial PP-independent relations between 1/PP amplification and LVMI or LVH. Similar results were noted when brachial SBP rather than PP was included in regression models and in sensitivity analysis conducted in participants not receiving antihypertensive therapy. In conclusion, the independent relations between the reciprocal of aortic-to-brachial PP amplification and LVMI or LVH in a largely young-to-middle-aged sample are accounted for by variations in backward wave pressures rather than aortic stiffness.

      PubDate: 2017-04-18T22:01:34Z
      DOI: 10.1016/j.jash.2017.04.003
       
 
 
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