for Journals by Title or ISSN
for Articles by Keywords
help
  Subjects -> HISTORY (Total: 1302 journals)
    - HISTORY (816 journals)
    - History (General) (51 journals)
    - HISTORY OF AFRICA (49 journals)
    - HISTORY OF ASIA (55 journals)
    - HISTORY OF AUSTRALASIA AREAS (8 journals)
    - HISTORY OF EUROPE (170 journals)
    - HISTORY OF THE AMERICAS (129 journals)
    - HISTORY OF THE NEAR EAST (24 journals)

HISTORY (816 journals)            First | 1 2 3 4 5     

Showing 601 - 452 of 452 Journals sorted alphabetically
Postcolonial Directions in Education     Open Access   (Followers: 1)
Postcolonial Studies     Hybrid Journal   (Followers: 15)
Postcolonial Text     Open Access   (Followers: 11)
Préhistoires méditerranéennes     Open Access   (Followers: 2)
Proceedings of the Aristotelian Society (hardback)     Hybrid Journal   (Followers: 4)
Proceedings of the Institution of Civil Engineers - Engineering History and Heritage     Hybrid Journal   (Followers: 3)
Proceedings of the Linnean Society of New South Wales     Full-text available via subscription   (Followers: 1)
Proceedings of the Royal Society of Queensland, The     Full-text available via subscription   (Followers: 1)
Proceedings of the Zoological Society     Hybrid Journal   (Followers: 2)
Procesos Historicos     Open Access  
Prose Studies: History, Theory, Criticism     Hybrid Journal   (Followers: 4)
Psychoanalysis and History     Hybrid Journal   (Followers: 3)
Psychoanalysis Culture & Society     Hybrid Journal   (Followers: 8)
Publications du Centre Européen d'Etudes Bourguignonnes     Full-text available via subscription  
Purdue Historian     Open Access  
Quaderns d’Història de l’Enginyeria     Open Access  
Quaker History     Full-text available via subscription   (Followers: 6)
Queensland Naturalist     Full-text available via subscription  
Questes : Revue pluridisciplinaire d'études médiévales     Open Access  
Quintana. Revista de Estudos do Departamento de Historia da Arte     Open Access  
Radical History Review     Full-text available via subscription   (Followers: 25)
Rasenna : Journal of the Center for Etruscan Studies     Open Access   (Followers: 3)
Rationality and Society     Hybrid Journal   (Followers: 6)
Raven : A Journal of Vexillology     Hybrid Journal  
Reinardus     Hybrid Journal  
Relaciones. Estudios de historia y sociedad     Open Access  
Renaissance Drama     Full-text available via subscription   (Followers: 8)
Renaissance Quarterly     Full-text available via subscription   (Followers: 44)
Renaissance Studies     Hybrid Journal   (Followers: 21)
Rethinking History: The Journal of Theory and Practice     Hybrid Journal   (Followers: 27)
Reti Medievali Rivista     Open Access   (Followers: 2)
Review of Central and East European Law     Hybrid Journal   (Followers: 9)
Reviews in American History     Full-text available via subscription   (Followers: 17)
Revista Alétheia     Open Access  
Revista Análisis Internacional     Open Access  
Revista Brasileira de Historia     Open Access   (Followers: 3)
Revista Brasileira de História das Religiões     Open Access  
Revista Chilena de Historia del Derecho     Open Access   (Followers: 1)
Revista Crítica Histórica     Open Access  
Revista de Divulgação Interdisciplinar     Open Access  
Revista de Estudios Historico-Juridicos     Open Access   (Followers: 1)
Revista de História     Open Access  
Revista de História Bilros. História(s), Sociedade(s) e Cultura(s)     Open Access   (Followers: 1)
Revista de História da UEG     Open Access  
Revista do Instituto Histórico e Geográfico do Rio Grande do Sul     Open Access  
Revista Historia Autónoma     Open Access  
Revista História da Educação - History of Education Journal     Open Access  
Revista Maracanan     Open Access  
Revista Memória em Rede     Open Access  
Revista Mosaico     Open Access  
Revista Paginas     Open Access  
Revolutionary Russia     Hybrid Journal   (Followers: 8)
Revue archéologique de l'Est     Open Access   (Followers: 3)
Revue archéologique du Centre de la France     Open Access   (Followers: 2)
Revue d'histoire de l'Amérique française     Full-text available via subscription   (Followers: 1)
Revue d'Histoire de l'Eglise de France     Full-text available via subscription   (Followers: 4)
Revue d'histoire de l'enfance     Open Access  
Revue d'Histoire des Textes     Full-text available via subscription  
Revue d'histoire du XIXe siècle     Open Access   (Followers: 7)
Revue d'Histoire Ecclésiastique     Full-text available via subscription   (Followers: 1)
Revue de l’Histoire des Religions     Open Access   (Followers: 11)
Revue des Études Arméniennes     Full-text available via subscription   (Followers: 2)
Revue d’études comparatives Est-Ouest (RECEO)     Open Access  
Revue historique des armées     Open Access   (Followers: 3)
Revue Mabillon     Full-text available via subscription   (Followers: 6)
Rhetoric Society Quarterly     Hybrid Journal   (Followers: 15)
RIHA Journal     Open Access   (Followers: 5)
RIMA: Review of Indonesian and Malaysian Affairs     Full-text available via subscription   (Followers: 1)
Romanticism     Hybrid Journal   (Followers: 5)
Romanticism and Victorianism on the Net     Open Access   (Followers: 6)
Royal Studies Journal     Open Access   (Followers: 1)
Rúbrica Contemporánea     Open Access  
Russian Education & Society     Full-text available via subscription   (Followers: 5)
Russian History     Hybrid Journal   (Followers: 15)
Russian Review     Hybrid Journal   (Followers: 19)
Sacris Erudiri     Full-text available via subscription   (Followers: 6)
Saeculum : Jahrbuch für Universalgeschichte     Hybrid Journal   (Followers: 1)
Safundi : The Journal of South African and American Studies     Hybrid Journal   (Followers: 1)
Scandinavian Journal of History     Hybrid Journal   (Followers: 14)
Scando-Slavica     Hybrid Journal   (Followers: 4)
Science & Society     Full-text available via subscription   (Followers: 5)
Science Journal of Volgograd State University. History. Area Studies. International Relations     Open Access  
Scientia Canadensis: Canadian Journal of the History of Science, Technology and Medicine / Scientia Canadensis : revue canadienne d'histoire des sciences, des techniques et de la médecine     Full-text available via subscription   (Followers: 5)
Scientia Militaria : South African Journal of Military Studies     Open Access   (Followers: 6)
Scientiae Studia     Open Access  
Scottish Historical Review     Hybrid Journal   (Followers: 17)
Scrineum Rivista     Open Access  
Scrutiny2: Issues in English Studies in Southern Africa     Hybrid Journal   (Followers: 1)
Senses and Society     Hybrid Journal   (Followers: 5)
Serendipities : Journal for the Sociology and History of the Social Sciences     Open Access  
SHARE : Studies in History, Archaeology, Religion and Conservation     Open Access  
Sibirica     Full-text available via subscription  
Siècles     Open Access   (Followers: 1)
Signals     Full-text available via subscription   (Followers: 2)
Signos Historicos     Open Access  
Slagmark - Tidsskrift for idéhistorie     Open Access   (Followers: 4)
Slavery & Abolition: A Journal of Slave and Post-Slave Studies     Hybrid Journal   (Followers: 11)
Slavonica     Hybrid Journal   (Followers: 3)
Social History     Hybrid Journal   (Followers: 47)
Social History of Medicine     Hybrid Journal   (Followers: 21)
Social Sciences and Missions     Hybrid Journal   (Followers: 4)
Società e Storia     Full-text available via subscription   (Followers: 1)
Society     Hybrid Journal   (Followers: 5)
Society and Economy     Full-text available via subscription   (Followers: 2)
SourceOECD National Accounts & Historical Statistics     Full-text available via subscription  
South African Historical Journal     Hybrid Journal   (Followers: 6)
South African Journal of Art History     Full-text available via subscription   (Followers: 2)
South African Journal of Cultural History     Full-text available via subscription   (Followers: 1)
South African Journal of Economic History     Full-text available via subscription   (Followers: 3)
South Asia Research     Hybrid Journal   (Followers: 8)
South Asia: Journal of South Asian Studies     Hybrid Journal   (Followers: 14)
South Asian History and Culture     Hybrid Journal   (Followers: 3)
South Asian Popular Culture     Hybrid Journal   (Followers: 2)
South Asian Survey     Hybrid Journal   (Followers: 5)
South Australian Naturalist, The     Full-text available via subscription  
South Central Review     Full-text available via subscription  
South European Society and Politics     Hybrid Journal   (Followers: 9)
Southeast European and Black Sea Studies     Hybrid Journal   (Followers: 5)
Southwestern Historical Quarterly     Full-text available via subscription   (Followers: 5)
Soviet and Post-Soviet Review     Hybrid Journal   (Followers: 9)
Spontaneous Generations : A Journal for the History and Philosophy of Science     Open Access   (Followers: 2)
Sport in History     Hybrid Journal   (Followers: 11)
Studia Aurea : Revista de Literatura Española y Teoría Literaria del Renacimiento y Siglo de Oro     Open Access   (Followers: 1)
Studia Historiae Ecclesiasticae     Open Access   (Followers: 2)
Studia Historiae Oeconomicae     Open Access  
Studia Iranica     Full-text available via subscription   (Followers: 5)
Studia Litteraria et Historica     Open Access  
Studia z Historii Filozofii     Open Access  
Studies in East European Thought     Hybrid Journal   (Followers: 6)
Studies in Eighteenth Century Culture     Full-text available via subscription   (Followers: 21)
Studies in History     Hybrid Journal   (Followers: 25)
Studies in History and Philosophy of Science Part A     Hybrid Journal   (Followers: 9)
Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences     Hybrid Journal   (Followers: 13)
Studies in People’s History     Hybrid Journal  
Studies in the History of Gardens & Designed Landscapes: An International Quarterly     Hybrid Journal   (Followers: 8)
Studies in Western Australian History     Full-text available via subscription   (Followers: 3)
Studium : Tijdschrift voor Wetenschaps- en Universiteits-geschiedenis / Revue d'Histoire des Sciences et des Universités     Open Access   (Followers: 1)
Suomen Sukututkimusseuran Vuosikirja     Open Access  
Sydney Institute Quarterly     Full-text available via subscription  
T'oung Pao     Hybrid Journal   (Followers: 12)
Tangence     Full-text available via subscription  
Tartu Ülikooli ajaloo küsimusi     Open Access  
Tasmanian Historical Studies     Full-text available via subscription   (Followers: 1)
Teaching History     Full-text available via subscription   (Followers: 7)
Technology and Culture     Full-text available via subscription   (Followers: 24)
temp - tidsskrift for historie     Full-text available via subscription  
Tempo     Open Access   (Followers: 2)
Tempo e Argumento     Open Access  
Temporalidades     Open Access  
The Corvette     Open Access  
The Court Historian : The International Journal of Court Studies     Full-text available via subscription   (Followers: 1)
The Eighteenth Century     Full-text available via subscription   (Followers: 28)
The European Legacy: Toward New Paradigms     Hybrid Journal   (Followers: 2)
The Hilltop Review : A Journal of Western Michigan University Graduate Student Research     Open Access  
The Historian     Hybrid Journal   (Followers: 34)
The International History Review     Hybrid Journal   (Followers: 23)
The Irish Review     Full-text available via subscription   (Followers: 15)
The Italianist     Hybrid Journal   (Followers: 5)
The Journal of the Historical Society     Hybrid Journal   (Followers: 13)
The Public Historian     Full-text available via subscription   (Followers: 11)
The Seventeenth Century     Hybrid Journal   (Followers: 18)
The Sixties: A Journal of History, Politics and Culture     Hybrid Journal   (Followers: 11)
The South African Journal of Economics     Hybrid Journal   (Followers: 4)
Theatre History Studies     Full-text available via subscription   (Followers: 5)
Theoria et Historia Scientiarum     Open Access  
Tiempo devorado     Open Access  
Tiempo y Espacio     Open Access  
Tijdschrift voor Geschiedenis     Full-text available via subscription   (Followers: 3)
Tijdschrift voor Rechtsgeschiedenis / Revue d'Histoire du Droit / The Legal History Review     Hybrid Journal   (Followers: 21)
Time & Society     Hybrid Journal   (Followers: 11)
Trabajos y Comunicaciones     Open Access   (Followers: 1)
Traditio     Full-text available via subscription   (Followers: 2)
Trans-pasando Fronteras     Open Access  
Transactions of the Philological Society     Hybrid Journal   (Followers: 2)
Transactions of the Royal Society of South Africa     Hybrid Journal   (Followers: 2)
Transfers     Full-text available via subscription  
Transition     Full-text available via subscription   (Followers: 1)
Transmodernity : Journal of Peripheral Cultural Production of the Luso-Hispanic World     Open Access   (Followers: 3)
Trocadero     Open Access  
Troianalexandrina     Full-text available via subscription   (Followers: 1)
Turcica     Full-text available via subscription   (Followers: 10)
Turkish Historical Review     Hybrid Journal   (Followers: 6)
Turkish Studies     Hybrid Journal   (Followers: 11)
Twentieth Century British History     Hybrid Journal   (Followers: 18)
U.S. Catholic Historian     Full-text available via subscription   (Followers: 2)
UCLA Historical Journal     Open Access   (Followers: 1)
Ufahamu : A Journal of African Studies     Open Access   (Followers: 2)
United Service     Full-text available via subscription   (Followers: 2)
Urban History Review / Revue d'histoire urbaine     Full-text available via subscription   (Followers: 6)
Varia Historia     Open Access   (Followers: 2)
Vegueta : Anuario de la Facultad de Geografía e Historia     Open Access  
Vestiges : Traces of Record     Full-text available via subscription  
Viator     Full-text available via subscription   (Followers: 14)
Victorian Naturalist, The     Full-text available via subscription   (Followers: 3)
Victorian Periodicals Review     Full-text available via subscription   (Followers: 9)
Vigiliae Christianae     Hybrid Journal   (Followers: 12)
Viking and Medieval Scandinavia     Full-text available via subscription   (Followers: 15)
Vínculos de Historia. Revista del Departamento de Historia de la Universidad de Castilla-La Mancha     Open Access  
Visual Resources: An International Journal of Documentation     Hybrid Journal   (Followers: 2)
Vivarium     Hybrid Journal   (Followers: 2)

  First | 1 2 3 4 5     

Journal Cover Journal of the American Society of Hypertension
  [SJR: 1.039]   [H-I: 31]   [9 followers]  Follow
    
   Hybrid Journal Hybrid journal (It can contain Open Access articles)
   ISSN (Print) 1933-1711
   Published by Elsevier Homepage  [3043 journals]
  • Fibroblast growth factor-23 is independently associated with cardiac mass
           in African-American adolescent males
    • Authors: Bonita Falkner; Scott W. Keith; Samuel S. Gidding; Craig B. Langman
      Pages: 480 - 487
      Abstract: Publication date: August 2017
      Source:Journal of the American Society of Hypertension, Volume 11, Issue 8
      Author(s): Bonita Falkner, Scott W. Keith, Samuel S. Gidding, Craig B. Langman
      Left ventricular hypertrophy has been documented in hypertensive adolescents and among some with prehypertension. Obesity also appears to be associated with cardiac mass, independent of blood pressure (BP). Fibroblast growth factor 23 (FGF23) is a novel biomarker positively associated with left ventricular hypertrophy in adults with and without kidney disease. The aim of this study was to determine if there was a significant and independent association of FGF23 with cardiac mass in a Black American adolescent cohort including both normotensive and prehypertensive participants with and without obesity. Measurements of BP, body mass index (BMI), plasma c-terminal FGF23, and echocardiographic measures of left ventricular mass index (LVMI) were obtained in 236 adolescents, aged 13–18 years, stratified by BMI as normal, overweight, or obese. LVMI differed significantly between normal, overweight, and obese groups (30.42 ± 6.75 vs. 33.49 ± 8.65 vs. 37.26 ± 6.99 gm/m2.7; P < .01). FGF23 was significantly higher in both overweight (53.03 RU/mL) and obese (54.40 RU/mL) compared to the normal weight (32.83 RU/mL) group (both P < .01). In multiple linear regression analysis, variables significantly related to LVMI in males were BMI (P < .0001) and FGF23 (P = .005), but not BP, high-sensitivity C-reactive protein, or insulin. The only significant variable associated with LVMI in females was BMI (P < .0001). In males, the contribution of FGF23 to predicting LVMI was independent of and in addition to obesity. These results suggest that FGF23 is an integral part of a complex pathway, associated with higher cardiac mass in African-Americans males with excess adiposity.

      PubDate: 2017-09-01T20:54:54Z
      DOI: 10.1016/j.jash.2017.04.001
       
  • Hypothyroidism as a cause of secondary hypertension - Myth dispelled
    • Authors: Franz H. Messerli; Louis Hofstetter; Ronald Victor; David Cerny
      First page: 615
      Abstract: Publication date: October 2017
      Source:Journal of the American Society of Hypertension, Volume 11, Issue 10
      Author(s): Franz H. Messerli, Louis Hofstetter, Ronald Victor, David Cerny


      PubDate: 2017-10-18T12:21:18Z
      DOI: 10.1016/j.jash.2017.09.003
       
  • Association of Interleukin-6 With Aortic Stiffness In End-Stage Renal
           Disease
    • Authors: Marie-Pier DESJARDINS; Aboubacar SIDIBÉ; Catherine FORTIER; Fabrice MAC-WAY; Karine MARQUIS; Sacha DE. SERRES; Richard LARIVIÈRE; Mohsen AGHARAZII
      Abstract: Publication date: Available online 13 October 2017
      Source:Journal of the American Society of Hypertension
      Author(s): Marie-Pier DESJARDINS, Aboubacar SIDIBÉ, Catherine FORTIER, Fabrice MAC-WAY, Karine MARQUIS, Sacha DE. SERRES, Richard LARIVIÈRE, Mohsen AGHARAZII
      Objectives Cardiovascular disease (CVD) is the leading cause of mortality in patients with chronic kidney disease (CKD). Aortic stiffness, a non-traditional risk factor, is associated with high rate of mortality in CKD. Using a CKD animal model with medial vascular calcification, we previously reported increased mRNA expression of interleukin-6 (IL-6), tumor necrosis factor (TNF) and interleukin-1β (IL-1β) in calcified aorta. The aim of the study was to investigate the association between IL-6, TNF, IL-1β and aortic stiffness in ESRD patients. Methods In a cross-sectional study, we enrolled 351 patients on dialysis. Aortic stiffness was assessed by carotid-femoral pulse wave velocity (cf-PWV) while central pulse pressure (PP) and augmentation index (AIx) were assessed using generalized transfer function applied to the radial artery pressure wave form. Plasma IL-6, TNF and IL-1β were measured by ELISA. Results IL-6 was associated with cf-PWV adjusted for mean blood pressure (MBP) (Standardized β=0.270; P<0.001). In a multivariate adjusted model for age, diabetes, hypertension, CVD and MBP, IL-6 was still associated with cf-PWV (Standardized β=0.096; P=0.026). The impact of age, diabetes and CVD on cf-PWV was partially mediated by IL-6 in a mediation analysis. However, there were no associations between TNF, IL-1β and aortic stiffness. While IL-6 was associated with AIx (Standardized β=0.224; P<0.001) and central PP (Standardized β=0.162; P=0.001) when adjusted for MBP and heart rate, this relationship was not significant after adjusting for potential confounders. Conclusion This study suggests a potential role of IL-6 for CKD-related aortic stiffness.

      PubDate: 2017-10-18T12:21:18Z
      DOI: 10.1016/j.jash.2017.09.013
       
  • Role of angiotensin II type 2 receptor during electrophysiological
           remodeling of left ventricular hypertrophic myocardium in spontaneously
           hypertensive rats
    • Authors: Xiao Ying; Long Wei-Qing; Guan Kai-Pan; Long Ming; Lu Gui-Hua; Huang Zhi-Bin
      Abstract: Publication date: Available online 13 October 2017
      Source:Journal of the American Society of Hypertension
      Author(s): Xiao Ying, Long Wei-Qing, Guan Kai-Pan, Long Ming, Lu Gui-Hua, Huang Zhi-Bin
      The objective was to investigate the role of angiotensin II type 2 receptor during electrophysiological remodeling of left ventricular hypertrophic myocardium in spontaneously hypertensive rats (SHR). A total of 36 10-week-old male SHR were divided into 3 groups: control, valsartan and valsartan+PD123319 groups (n=12 in each). The systolic blood pressure, left ventricular mass index (LVMI), ventricular effective refractory period, and ventricular fibrillation threshold (VFT) were also measured after eight weeks. At the same time, INa, ICaL, Ito and membrane capacitance were measured in left ventricular myocytes by whole-cell patch-clamp. The VFT of valsartan was higher than that of control (valsartan vs. control: 17.4±0.6mA vs. 15.8±0.5mA, P<0.05). The VFT of valsartan was higher than that of valsartan+PD123319 (valsartan vs. valsartan+PD123319: (17.4±0.6mA vs. 16.6±0.9mA, P<0.05). The density of Ito of valsartan was higher than that of control (valsartan vs. control: 14.7±0.42pA/pF vs. 11.2±0.15pA/pF, P<0.05). The density of Ito of valsartan was higher than that of valsartan+PD123319 (valsartan vs. valsartan+PD123319: 14.7±0.42pA/pF vs. 13.6±0.30pA/pF, P<0.05). The density of ICaL of valsartan was lower than that of control (valsartan vs. control: -4.6±0.2pA/pF vs. -6.9±0.1pA/pF, P<0.05). The density of ICaL of valsartan was lower than that of valsartan+PD123319 (valsartan vs. valsartan+PD123319: -4.6±0.2pA/pF vs. -5.4±0.1pA/pF, P<0.05). These results demonstrated that the stimulation of angiotensin II type 2 receptor improved electrophysiological remodeling of left ventricular hypertrophic myocardium in SHR.

      PubDate: 2017-10-18T12:21:18Z
      DOI: 10.1016/j.jash.2017.09.014
       
  • Albuminuria and Kidney Function as Prognostic Marker of Left Ventricular
           Mass among South Asians with Hypertension
    • Authors: Liang Feng; Aamir Hameed Khan; Imtiaz Jehan; John Allen; Tazeen H. Jafar
      Abstract: Publication date: Available online 13 October 2017
      Source:Journal of the American Society of Hypertension
      Author(s): Liang Feng, Aamir Hameed Khan, Imtiaz Jehan, John Allen, Tazeen H. Jafar
      We aimed to evaluate the association of albuminuria and estimated glomerular filtration rate (eGFR) at baseline and changes in these parameters with left ventricular mass index (LVMI) at 7 years in adults with hypertension from communities in Pakistan. A nested cohort of 539 hypertensives aged 40 years and older from a community-living population in Karachi, Pakistan followed up for 7 years in the Control of Blood Pressure and Risk Attenuation (COBRA) trial. Urine spot albumin to creatinine ratio (UACR) and serum creatinine-based eGFR were assessed at baseline and 7 years, and echocardiography at 7 years. Mean age of participants was 50.9±9.1 (SD) years; 63% were female. Mean eGFR was 91.0±15.9 (SD) ml/min/1.73 m2, and median (IQR) UACR 6.2 (3.9, 11.3) mg/g. In multivariate analysis, although baseline eGFR was marginally associated with LVMI, a strong association was found between higher LVMI with greater rate of decline in eGFR (β = -1.05, 95% CI (-1.94, -0.17)). Higher baseline UACR was significantly associated with higher follow-up LVMI (β = 2.26, 95% CI (0.87, 3.65)), as was rate of UACR increase of ≥1.07 mg/g/year vs. of <0.14 mg/g/year. (β = 4.19, 95% CI (0.75, 7.63)). Associations with developing left ventricular hypertrophy (LVH) were found for reduced baseline eGFR, higher baseline UACR, and greater rate of UACR increase, but not for rate of eGFR decline. Comparable results were observed for the outcomes of posterior wall thickness and septal wall thickness. Higher baseline albuminuria, lower baseline eGFR and their longitudinal worsening were significantly associated with higher LVMI or the development of LVH among individuals with hypertension in Pakistan.

      PubDate: 2017-10-18T12:21:18Z
      DOI: 10.1016/j.jash.2017.10.003
       
  • From the President, American Society of Hypertension
    • Authors: John D. Bisognano; Jan N. Basile
      Abstract: Publication date: Available online 12 October 2017
      Source:Journal of the American Society of Hypertension
      Author(s): John D. Bisognano, Jan N. Basile


      PubDate: 2017-10-18T12:21:18Z
      DOI: 10.1016/j.jash.2017.10.005
       
  • From the Editor
    • Authors: Daniel Levy
      Abstract: Publication date: October 2017
      Source:Journal of the American Society of Hypertension, Volume 11, Issue 10
      Author(s): Daniel Levy


      PubDate: 2017-10-18T12:21:18Z
       
  • Instructions for Authors
    • Abstract: Publication date: October 2017
      Source:Journal of the American Society of Hypertension, Volume 11, Issue 10


      PubDate: 2017-10-18T12:21:18Z
       
  • Potassium homeostasis in health and disease: A scientific workshop
           cosponsored by the National Kidney Foundation and the American Society of
           Hypertension
    • Authors: Csaba Kovesdy; Lawrence Appel Morgan Grams Lisa Gutekunst Peter McCullough
      Abstract: Publication date: Available online 10 October 2017
      Source:Journal of the American Society of Hypertension
      Author(s): Csaba P. Kovesdy, Lawrence J. Appel, Morgan E. Grams, Lisa Gutekunst, Peter A. McCullough, Biff F. Palmer, Bertram Pitt, Dominic A. Sica, Raymond R. Townsend
      While much emphasis, and some controversy, centers on recommendations for sodium intake, there has been considerably less interest in recommendations for dietary potassium intake, in both the general population and patients with medical conditions, particularly acute and chronic kidney disease. Physiology literature and cohort studies have noted that the relative balance in sodium and potassium intakes is an important determinant of many of the sodium-related outcomes. A noteworthy characteristic of potassium in clinical medicine is the extreme concern shared by many practitioners when confronted by a patient with hyperkalemia. Fear of this often asymptomatic finding limits enthusiasm for recommending potassium intake and often limits the use of renin-angiotensin-aldosterone system blockers in patients with heart failure and chronic kidney diseases. New agents for managing hyperkalemia may alter the long-term management of heart failure and the hypertension, proteinuria, and further function loss in chronic kidney diseases. In this jointly sponsored effort between the American Society of Hypertension and the National Kidney Foundation, 3 panels of researchers and practitioners from various disciplines discussed and summarized current understanding of the role of potassium in health and disease, focusing on cardiovascular, nutritional, and kidney considerations associated with both hypo- and hyperkalemia.

      PubDate: 2017-10-11T05:16:47Z
       
  • Body weight-dependent relationships between alcohol consumption and pulse
           pressure in middle-aged Japanese women
    • Authors: Ichiro Wakabayashi
      Abstract: Publication date: Available online 3 October 2017
      Source:Journal of the American Society of Hypertension
      Author(s): Ichiro Wakabayashi
      High pulse pressure is a risk factor for cardiovascular disease, and excessive alcohol drinking increases the risk of hypertension. The purpose of this study was to elucidate the relationship between alcohol intake and pulse pressure in women and to determine whether body weight influences their relationship. The subjects were 18791 Japanese middle-aged women and they were divided into tertile groups for body weight or three different body mass index (BMI, kg/m 2 ) groups (low BMI, < 22; middle BMI, ≥ 22 and < 25; high BMI, ≥ 25). The subjects in each group were further divided into four groups of nondrinkers, occasional drinkers, regular light drinkers and regular heavy drinkers by habitual alcohol consumption. Pulse pressure levels were compared between nondrinkers and drinkers in each group for body weight or BMI. Pulse pressure was significantly higher in regular heavy drinkers than in nondrinkers in the 1st tertile group for body weight and in the low BMI group but not in the 2nd and 3rd tertile groups for body weight and in the middle and high BMI groups. In all tertile groups and all BMI groups, pulse pressure was not significantly different in occasional drinkers and regular light drinkers than in nondrinkers. In women with lower body weight, heavy drinking was positively associated with pulse pressure, while this association was not found in women with middle or higher body weight. Thus, body weight potently confounds the relationship between alcohol consumption and pulse pressure.

      PubDate: 2017-10-04T03:30:07Z
      DOI: 10.1016/j.jash.2017.09.012
       
  • The burden and correlates of hypertension among Chinese rural population
           in Han, Uygur and Kazak : A cross- sectional study
    • Authors: Yong-tao Wang; Dilare Adi; Zi-xiang Yu; Yi-Tong Ma; Yi-Ning Yang; Xiao-mei Li; Xiang Ma; Fen Liu; Bang-Dang Chen
      Abstract: Publication date: Available online 28 September 2017
      Source:Journal of the American Society of Hypertension
      Author(s): Yong-tao Wang, Dilare Adi, Zi-xiang Yu, Yi-Tong Ma, Yi-Ning Yang, Xiao-mei Li, Xiang Ma, Fen Liu, Bang-Dang Chen
      The present study was conducted to investigate the prevalence, awareness, treatment, control, and associated risk factors of hypertension among rural population in Xinjiang Province in northwest China. The Cardiovascular Risk Survey (CRS) study was conducted on a representative sample of the northwest China adult population. A 4-stage stratified cluster random sampling scheme was adopted to recruit representative samples. The data was collected by trained staff. Multivariable logistic regression models were used to identify the associated risk factors. Overall, 8295 study participants aged 35-101 years were enrolled. The overall hypertension prevalence was 35.01%%. The prevalence of hypertension in Han, Uygur and Kazak population was 36.84%, 33.32% and 52.57% respectively. The hypertension awareness, treatment, control and control among treated participants were 56.1%, 44.7%, 10.9% and 24.3% respectively. Multivariate logistic regression showed that age, BMI, central obesity, ethnic and drinking status were identified as risk factors for hypertension. Hypertension was found to be highly prevalent in rural adults in Xinjiang, China, especially in Kazak population. Though the levels of awareness, treatment, and control have improved, it was still lower than developed countries. Effective measures should be adopted to promote the prevention and control of hypertension.

      PubDate: 2017-10-04T03:30:07Z
      DOI: 10.1016/j.jash.2017.09.010
       
  • Air Pollution And Arterial Hypertension. A New Risk Factor Is In The Air
    • Authors: Elias Sanidas; Dimitris P. Papadopoulos; Harris Grassos; Maria Velliou; Kostas Tsioufis; John Barbetseas; Vasilios Papademetriou
      Abstract: Publication date: Available online 27 September 2017
      Source:Journal of the American Society of Hypertension
      Author(s): Elias Sanidas, Dimitris P. Papadopoulos, Harris Grassos, Maria Velliou, Kostas Tsioufis, John Barbetseas, Vasilios Papademetriou
      Air pollution is one of the greatest environmental threats and has been implicated for several adverse cardiovascular effects including arterial hypertension. However, the exact relationship between air pollution exposure and hypertension is still unclear. Air contamination provokes oxidative stress, systemic inflammation and autonomic nervous system imbalance that subsequently induce endothelial dysfunction and vasoconstriction leading to increased blood pressure. The aim of this review was to describe the potential mechanisms by which air pollution contributes to hypertension and to summarize the consequences of short and long term exposure.

      PubDate: 2017-10-04T03:30:07Z
      DOI: 10.1016/j.jash.2017.09.008
       
  • Cover 2: Staff appreciation notice
    • Abstract: Publication date: September 2017
      Source:Journal of the American Society of Hypertension, Volume 11, Issue 9


      PubDate: 2017-10-04T03:30:07Z
       
  • Prehypertension is Real and Can be Associated with Target Organ Damage
    • Authors: Barry J. Materson; Manuel Garcia-Estrada; Stephane B. Degraff; Richard A. Preston
      Abstract: Publication date: Available online 21 September 2017
      Source:Journal of the American Society of Hypertension
      Author(s): Barry J. Materson, Manuel Garcia-Estrada, Stephane B. Degraff, Richard A. Preston
      Prehypertension (systolic blood pressure 120-139 or diastolic blood pressure 80-89 mm Hg) confers a risk of progression to hypertension, impairment of cognitive function, increased left ventricular mass, risk of end-stage renal disease and an association with arteriosclerosis. Recent studies provide data that could support the rationale for treating prehypertensives subjects with antihypertensive medications in addition to lifestyle modification, especially if they have concomitant cardiovascular risk factors.

      PubDate: 2017-09-26T00:57:34Z
      DOI: 10.1016/j.jash.2017.09.005
       
  • From the Editor
    • Authors: Daniel Levy
      Abstract: Publication date: September 2017
      Source:Journal of the American Society of Hypertension, Volume 11, Issue 9
      Author(s): Daniel Levy


      PubDate: 2017-09-13T23:02:22Z
       
  • Announcement
    • Abstract: Publication date: September 2017
      Source:Journal of the American Society of Hypertension, Volume 11, Issue 9


      PubDate: 2017-09-13T23:02:22Z
       
  • Effects of chronic hepatitis C infection on arterial stiffness
    • Authors: Chang-Hua Chou; Chin-Shan Ho; Wei-Chuan Tsai; Ming-Cheng Wang; Yau-Sheng Tsai; Ju-Yi Chen
      Abstract: Publication date: Available online 26 August 2017
      Source:Journal of the American Society of Hypertension
      Author(s): Chang-Hua Chou, Chin-Shan Ho, Wei-Chuan Tsai, Ming-Cheng Wang, Yau-Sheng Tsai, Ju-Yi Chen
      Background Non-alcoholic fatty liver disease (NAFLD) is associated with increased arterial stiffness. Although chronic hepatitis C virus (HCV) infection was shown to be associated with metabolic disorder and chronic inflammation, the effects of chronic HCV infection on arterial stiffness remain unclear. Methods This study recruited 221 patients including 32 normal controls (NC), 72 NAFLD patients, and 117 subjects with HCV infection. Arterial stiffness was assessed by peripheral arterial stiffness index, Compliance Index (CI) and central arterial stiffness index, Stiffness Index (SI) derived from digital volume pulse by photoplethysmography. Levels of oxidative stress marker and inflammatory markers were also measured. Results The HCV group had significantly lower CI (4.8 ± 3.1 units vs. 3.9 ± 2.1 units vs. 3.0 ± 1.7 units; p for trend < 0.001) and higher SI (7.0 ± 1.6 m/s vs. 8.3 ± 2.3 m/s vs. 8.4 ± 2.3 m/s; p for trend = 0.001) compared to the NC and NAFLD groups. Multi-variate linear regression analysis showed that CI was independently correlated with systolic blood pressure (beta = -0.202, p = 0.013) and HCV infection (beta = -0.216, p = 0.036). Conclusion Chronic HCV infection was independently associated with peripheral arterial stiffness. Peripheral arterial stiffness in chronic HCV infection was not associated with a marker of general inflammation (hsCRP); however a role for more specific markers of inflammation cannot be ruled out.

      PubDate: 2017-09-01T20:54:54Z
      DOI: 10.1016/j.jash.2017.08.007
       
  • Increased platelet alpha2B–adrenergic receptor gene expression in
           well-controlled hypertensives: The effect of arterial stiffness
    • Authors: Maria E. Marketou; Joanna E. Kontaraki; John A. Papadakis; George E. Vrentzos; Alexandros Patrianakos; Konstantinos Fragkiadakis; Panagiotis Tsiverdis; Dimitris Lempidakis; Gregory Chlouverakis; Panos E. Vardas; Fragiskos I. Parthenakis
      Abstract: Publication date: Available online 26 August 2017
      Source:Journal of the American Society of Hypertension
      Author(s): Maria E. Marketou, Joanna E. Kontaraki, John A. Papadakis, George E. Vrentzos, Alexandros Patrianakos, Konstantinos Fragkiadakis, Panagiotis Tsiverdis, Dimitris Lempidakis, Gregory Chlouverakis, Panos E. Vardas, Fragiskos I. Parthenakis
      Introduction Catecholamines play a major role in atherothrombotic mechanisms in essential hypertension. Alpha2B–adrenergic receptors (α2B–ARs) are implicated in the pathophysiology of platelet aggregation. In this study, we evaluated platelet α2B–AR gene expression levels in patients with well-controlled essential hypertension compared to normal individuals and investigated their association with increased arterial stiffness. Methods Fifty-nine patients with well-controlled essential hypertension (34 men, mean age 65 ± 9 years) and 26 normotensives (19 men, mean age 64 ± 8 years) were included in the study. For each patient, carotid femoral pulse wave velocity (c-f PWV) and carotid radial PWV (c-r PWV) were evaluated. In addition, blood samples were obtained and platelets were isolated. The α2B-AR gene expression levels in platelets were examined by real time PCR for each participant. Results Well-controlled hypertensive patients showed significantly higher gene expression levels of α2B-Rs in platelets compared to normotensives (34.7 ± 29.5 versus 17.6 ± 12.5, respectively, p = 0.005). Interestingly, we found that c-f PWV and c-r PWV were positively correlated with platelet α2B-R gene expression levels (r = 0.59, p < 0.001, and r = 0.39, p = 0.002, respectively). Conclusions Platelet α2B-R gene expression levels are increased in patients with well-controlled essential hypertension compared to normotensives, and are correlated with increased PWV in those patients. Our data indicate an association of arterial stiffness and platelet α2B-Rs gene expression and indicate the need for further research.
      Graphical abstract image

      PubDate: 2017-09-01T20:54:54Z
      DOI: 10.1016/j.jash.2017.08.006
       
  • Soluble (Pro)Renin Receptor in Preeclampsia and Diabetic Pregnancies
    • Authors: Meryam Sugulle; Harald Heidecke; Ulrike Maschke; Florian Herse; A.H. Jan Danser; Dominik N. Mueller; Anne Cathrine Staff; Ralf Dechend
      Abstract: Publication date: Available online 24 August 2017
      Source:Journal of the American Society of Hypertension
      Author(s): Meryam Sugulle, Harald Heidecke, Ulrike Maschke, Florian Herse, A.H. Jan Danser, Dominik N. Mueller, Anne Cathrine Staff, Ralf Dechend
      Women with preexisting or gestational diabetes mellitus have an increased risk for developing preeclampsia. Diabetes and pregnancy are both characterized by very high prorenin levels and renin-angiotensin system activation. Prorenin bound to the (pro)renin receptor has enzymatic activity. We hypothesized that soluble (pro)renin receptor levels are elevated in high risk pregnancies. Third trimester maternal blood samples from complicated pregnancies (n=165), [preeclampsia (n=76), diabetes mellitus (type 1 diabetes, n=35; type 2 diabetes, n=11; gestational diabetes mellitus, n=43)], and healthy pregnancies (n=49) were analyzed for prorenin, renin and soluble (pro)renin receptor. There were no significant differences in prorenin or renin levels between the study groups in a multivariate model. In the group of women with gestational diabetes, soluble (pro)renin receptor concentrations were significantly higher as compared to healthy pregnancies or preeclampsia. Soluble (pro)renin receptor did not correlate with renin or prorenin levels for any of the study groups. Our results show that soluble (pro)renin receptor is dysregulated in pregnancies affected by diabetes mellitus, but not in preeclampsia. Alterations in circulating soluble (pro)renin receptor are unrelated to renin/prorenin in pregnancy, but may be of pathophysiological relevance in diabetic pregnancies in a renin-angiotensin system-independent manner.

      PubDate: 2017-09-01T20:54:54Z
      DOI: 10.1016/j.jash.2017.08.001
       
  • Contribution of Backward and Forward Wave Pressures to Age-Related
           Increases in Aortic Pressure in a Community Sample Not Receiving
           Antihypertensive Therapy.
    • Authors: Bryan Hodson; Gavin R. Norton; Imraan Ballim; Pinhas Sareli; Angela J. Woodiwiss
      Abstract: Publication date: Available online 24 August 2017
      Source:Journal of the American Society of Hypertension
      Author(s): Bryan Hodson, Gavin R. Norton, Imraan Ballim, Pinhas Sareli, Angela J. Woodiwiss
      Reports on the contribution of aortic forward (Pf) and backward (Pb) wave pressures to age-related increases in aortic pulse pressure (PPc) have been confounded by the use of participants receiving antihypertensive therapy. We assessed the relative contribution of Pf and Pb to age-related increases in PPc (radial applanation tonometry and SphygmoCor software using an assumed triangular wave for wave separation analysis) in 892 community participants not receiving antihypertensive therapy. We validated our results using aortic flow waves (echocardiography) for wave separation analysis in 254 of these participants. In multivariate regression models in those <50 years of age, adjustments for both Pb and a Pf-independent measure of reflected wave function (RM=Pb/Pf), but not Pf abolished the impact of age on PPc. However, in those older than 50 years of age, adjustments for Pf (β-coefficient: 0.25±0.06 vs 0.74±0.08 p<0.0001) and Pb (0.04±0.04 vs 0.74±0.08 p<0.0001), but not RM markedly decreased the relationship between age and PPc. On product of coefficient mediation analysis, whether assessed in men or in women, in those participants <50 years of age, independent of several confounders and mean arterial pressure (MAP), Pb (p<0.005), but not Pf contributed to age-related increases in PPc. In contrast, in those participants ≥50 years of age, independent of several confounders and MAP, Pb (p<0.005) and Pf (p<0.01) contributed to age-related increases in PPc, and Pb effects were markedly diminished by adjustments for Pf (0.26±0.002 vs 0.52±0.003 mm Hg per year, p<0.0001 for comparison). In conclusion, independent of the effects of antihypertensive therapy, aortic backward waves contribute to age-related increases in aortic PPc across the adult lifespan, but at an older age, this effect may be attributed in-part to the impact of forward on backward wave pressures.

      PubDate: 2017-09-01T20:54:54Z
      DOI: 10.1016/j.jash.2017.08.003
       
  • The 8-oxo-deoxiguanosine glycosylase increases its migration to
           mitochondria in compensated cardiac hypertrophy.
    • Authors: Jorge E. Vela-Guajardo; Perla Pérez-Treviño; Irais Rivera-Álvarez; Fabio A. González-Mondellini; Julio Altamirano; Noemí García
      Abstract: Publication date: Available online 24 August 2017
      Source:Journal of the American Society of Hypertension
      Author(s): Jorge E. Vela-Guajardo, Perla Pérez-Treviño, Irais Rivera-Álvarez, Fabio A. González-Mondellini, Julio Altamirano, Noemí García
      Cardiac hypertrophy is a compensatory mechanism maladapted because it presents an increase in the oxidative stress which could be associated with the development of the heart failure. A mechanism proposed is by mitochondrial DNA (mtDNA) oxidation, which evolved to a vicious cycle due the synthesis of proteins encoded in the genome is committed. Therefore, the aim of the present work was to evaluate the mtDNA damage and enzyme repairing, the 8-oxo-desoxiguanosine glycosylase mitochondrial isoform 1-2a (OGG1-2a) in the early stage of compensated cardiac hypertrophy induced by abdominal aortic constriction (AAC). Results showed that after six weeks of AAC hearts presented a compensated hypertrophy (22%), with an increase in the cell volume (35%), mitochondrial mass (12%) and mitochondrial membrane potential (94%). However, the increased of oxidative stress did not affect mtDNA, most probably because OGG1-2a, was found to increase 3.2 times in the mitochondrial fraction. Besides, mitochondrial function was not altered by the cardiac hypertrophy condition but in vitro mitochondria from AAC heart showed an increased sensibility to stress induced by the high Ca2+ concentration. Conclusion The increase in the oxidative stress in compensated cardiac hypertrophy induced the OGG1-2a migration to mitochondria to repair mtDNA oxidation, as a mechanism that allows maintaining the cardiac function in the compensatory stage.

      PubDate: 2017-09-01T20:54:54Z
      DOI: 10.1016/j.jash.2017.08.004
       
  • Postexercise hypotension during different water-based concurrent training
           intrasession sequences in young women
    • Authors: Stephanie Santana Pinto; Daniel Umpierre; Hector Kerchirne Ferreira; Gabriela Neves Nunes; Rodrigo Ferrari; Cristine Lima Alberton
      Abstract: Publication date: Available online 24 August 2017
      Source:Journal of the American Society of Hypertension
      Author(s): Stephanie Santana Pinto, Daniel Umpierre, Hector Kerchirne Ferreira, Gabriela Neves Nunes, Rodrigo Ferrari, Cristine Lima Alberton
      The purpose of the study was to compare the acute effects of water-based resistance-aerobic (RA) and aerobic-resistance (AR) sequences on systolic blood pressure, diastolic blood pressure (DBP), and mean blood pressure (MBP) in young women. Thirteen active women participated in four sessions: (1) exercises familiarization, (2) aquatic maximal test to determine the heart rate (HR) corresponding to the anaerobic threshold (HRAT), (3) concurrent protocol RA, and (4) concurrent protocol AR. Both protocols were initiated with the blood pressure measurements at rest in supine position. After that, either RA or AR concurrent protocol was performed. At the end of both protocols, blood pressure was measured throughout 60 minutes (every 10 minutes). The water-based resistance protocol was made up by exercises at maximal velocity, and the water-based aerobic protocol was performed at ±5 bpm of HRAT continuously. Two-way analysis of variance with repeated measures was used to analyze the data (α = 0.05). There was no hypotensive effect on systolic blood pressure among the time points (P = .235) in both water-based intrasession exercise sequences (P = .423). Regarding the DBP and MBP, both intrasession exercise sequences presented similar (DBP: P = .980; MBP: P = .796) hypotensive effects in the first 10 minutes (DBP: P = .003; MBP: P = .008) at the end of RA and AR sessions (DBP: −4 vs. −13 mm Hg; MBP: −3 vs. −10 mm Hg). It was concluded that both RA and AR water-based concurrent training sessions resulted in postexercise hypotension (DBP and MBP) in normotensive young women.

      PubDate: 2017-09-01T20:54:54Z
      DOI: 10.1016/j.jash.2017.08.002
       
  • Central Systolic Blood Pressure and Aortic Stiffness Response to Dietary
           Sodium in Young and Middle-Aged Adults
    • Authors: Bryce J. Muth; Michael S. Brian; Julio A. Chirinos; Shannon L. Lennon; William B. Farquhar; David G. Edwards
      Abstract: Publication date: Available online 28 July 2017
      Source:Journal of the American Society of Hypertension
      Author(s): Bryce J. Muth, Michael S. Brian, Julio A. Chirinos, Shannon L. Lennon, William B. Farquhar, David G. Edwards
      High dietary sodium intake can lead to hypertension and increased incidence of cardiovascular disease. We sought to determine the effect of short-term dietary sodium loading on central blood pressure and arterial stiffness in young (YG; 22-40 years) and middle-aged (MA; 41-60 years) normotensive adults. YG (n=49; age: 27±1 yrs) and MA (n=36; age: 52±1 yrs) subjects were randomized, in a cross-over design, to 7 days of low sodium (20mmol/day) or high sodium (300mmol/day) diet. On the last day of each diet, central pressures, forward and reflected wave amplitudes (via radial artery applanation tonometry) and carotid-femoral pulse wave velocity (CF-PWV) were assessed. Central systolic blood pressure (cSBP) was greater after HS in both YG (LS: 96±1 vs. HS: 99±1mmHg; p=0.012) and MA (LS: 106±2 vs. HS: 115±3mmHg; p<0.001). However, the increase in cSBP was greater in MA (YG: 4±1 vs. MA: 9±2; p=0.02). In MA subjects, HS elicited greater forward (LS: 25±1 vs. HS: 29±1mmHg; p<0.001) and reflected (LS: 19±1 vs. HS: 23±1mmHg; p<0.001) wave amplitudes. CF-PWV was also greater in MA on HS but after adjustment for MAP the difference was no longer significant. Our data indicate that HS intake leads to a greater increase in cSBP in MA adults, which may be the result of increased forward and reflected wave amplitudes.

      PubDate: 2017-08-03T16:08:26Z
      DOI: 10.1016/j.jash.2017.07.010
       
  • Galectin-3 mediates pulmonary vascular remodeling in hypoxia-induced
           pulmonary arterial hypertension
    • Authors: Hui Luo; Bin Liu; Lin Zhao; Jingni He; Tangzhiming Li; Lihuang Zha; Xiaohui Li; Qiangqiang Qi; Yuwei Liu; Zaixin Yu
      Abstract: Publication date: Available online 28 July 2017
      Source:Journal of the American Society of Hypertension
      Author(s): Hui Luo, Bin Liu, Lin Zhao, Jingni He, Tangzhiming Li, Lihuang Zha, Xiaohui Li, Qiangqiang Qi, Yuwei Liu, Zaixin Yu
      Objective Pulmonary vascular adventitia serves as a key regulator of pulmonary vascular remodeling in the pathogenesis of pulmonary arterial hypertension (PAH). Excessive proliferation and differentiation of pulmonary adventitial fibroblasts (PAFs) are proven to be crucial in the pathogenesis of PAH. Galectin-3 (Gal-3) is known as a key fibroblasts activing factor which is involved in the fibrogenesis of several diseases, such as pulmonary fibrosis, vascular fibrosis, and heart failure. Therefore, we seek to investigate the potential role of Gal-3 in regulating PAF cells in the pathogenesis of PAH. Result Gal-3 plasma concentration was significantly higher in PAH patients. Gal-3 was upregulated in pulmonary artery adventitia of hypoxia-induced PAH rats. Inhibition of Gal-3 with N-Acetyl-D-lactosamine (N-Lac) ameliorated PAH and pulmonary vascular remodeling. Gal-3 can stimulate the proliferation, differentiation and collagen synthesis of PAFs, which was reversed by N-Lac. TGF-β1 increased Gal-3 expression in PAFs, while N-Lac significantly suppressed TGF-β1-induced proliferation, differentiation and collagen synthesis of PAFs. Conclusion Gal-3 serves as a critical regulator in the pathogenesis of PAH by regulating the proliferation, differentiation and extracellular matrix deposition synthesis of PAFs. Inhibition of Gal-3 may represent a novel therapeutic target for PAH treatment.

      PubDate: 2017-08-03T16:08:26Z
      DOI: 10.1016/j.jash.2017.07.009
       
  • Is there a role for very low–dose combination therapy in
           hypertension management'
    • Authors: Brent M. Egan
      Abstract: Publication date: Available online 26 July 2017
      Source:Journal of the American Society of Hypertension
      Author(s): Brent M. Egan


      PubDate: 2017-08-03T16:08:26Z
      DOI: 10.1016/j.jash.2017.07.007
       
  • Terminal decline in systolic blood pressure in octogenarians
    • Authors: Michael J. Bloch
      Abstract: Publication date: Available online 23 July 2017
      Source:Journal of the American Society of Hypertension
      Author(s): Michael J. Bloch


      PubDate: 2017-07-23T14:20:28Z
      DOI: 10.1016/j.jash.2017.07.003
       
  • Tumor necrosis factor-α receptor 1 (TNFR1) contributes to ethanol-induced
           vascular reactive oxygen species generation and hypertension
    • Authors: Janaina A. Simplicio; Natália A. Gonzaga; Marcelo A. Nakashima; Bruno S. De Martinis; Thiago Mattar Cunha; Luis F. Tirapelli; Carlos R. Tirapelli
      Abstract: Publication date: Available online 22 July 2017
      Source:Journal of the American Society of Hypertension
      Author(s): Janaina A. Simplicio, Natália A. Gonzaga, Marcelo A. Nakashima, Bruno S. De Martinis, Thiago Mattar Cunha, Luis F. Tirapelli, Carlos R. Tirapelli
      We evaluated the contribution of TNF-α receptor 1 (TNFR1) to ethanol-induced hypertension and vascular oxidative stress and the possible role of perivascular adipose tissue (PVAT) in such response. Male C57BL/6 wild-type (WT) or TNFR1-deficient mice (TNFR1-/-) were treated with ethanol (20% v/v) for 12 weeks. Ethanol induced an increase in blood pressure in WT and TNFR1−/– mice at 4 and 5 weeks of treatment, respectively. Treatment with ethanol increased TNF-α and interleukin (IL)-6 levels in aortas with or without PVAT (PVAT+ and PVAT-, respectively) from WT, but not TNFR1-/- mice. Ethanol increased superoxide anion (O2 -) generation, TBARS concentration and the activity of superoxide dismutase (SOD) and catalase in aortas (PVAT- and PVAT+) from WT, but not TNFR1−/- mice. Conversely, ethanol consumption decreased the concentration of nitrate/nitrite (NOx) in aortas (PVAT- and PVAT+) from WT, but not TNFR1-/- mice. Treatment with ethanol increased myeloperoxidase (MPO) activity in aortas (PVAT- and PVAT+) from WT, but not TNFR1-/- mice. The major finding of our study is that TNFR1 contributes to ethanol-induced hypertension and oxidative stress in the vasculature. Additionally, TNFR1 plays a role in ethanol-induced increase in pro-inflammatory cytokines and neutrophils migration. However, PVAT does not counteract or aggravate the effects induced by ethanol.
      Graphical abstract image

      PubDate: 2017-07-23T14:20:28Z
      DOI: 10.1016/j.jash.2017.07.008
       
  • The Effect of Empagliflozin on Muscle Sympathetic Nerve Activity in
           Patients with Type 2 Diabetes Mellitus
    • Authors: Jens Jordan; Jens Tank; Karsten Heusser; Tim Heise; Christoph Wanner; Martina Heer; Sreeraj Macha; Michaela Mattheus; Søren S. Lund; Hans J. Woerle; Uli C. Broedl
      Abstract: Publication date: Available online 21 July 2017
      Source:Journal of the American Society of Hypertension
      Author(s): Jens Jordan, Jens Tank, Karsten Heusser, Tim Heise, Christoph Wanner, Martina Heer, Sreeraj Macha, Michaela Mattheus, Søren S. Lund, Hans J. Woerle, Uli C. Broedl
      Background Inhibition of sodium glucose cotransporter 2 (SGLT2) with empagliflozin results in caloric loss by increasing urinary glucose excretion and has a mild diuretic effect. Diuretic effects are usually associated with reflex-mediated increases in sympathetic tone, whereas caloric loss is associated with decreased sympathetic tone. Methods and Results In an open-label trial, muscle sympathetic nerve activity (burst frequency, burst incidence and total muscle sympathetic nerve activity) was assessed using microneurography performed off-treatment and on day 4 of treatment with empagliflozin 25 mg once daily in 22 metformin-treated patients with type 2 diabetes (mean [range] age 54 [40–65] years). Systolic and diastolic blood pressure, heart rate, urine volume and body weight were assessed before and on day 4 (blood pressure, heart rate), day 5 (urine volume) or day 6 (body weight) of treatment with empagliflozin. After 4 days of treatment with empagliflozin, no significant changes in muscle sympathetic nerve activity were apparent despite a numerical increase in urine volume, numerical reductions in blood pressure, and significant weight loss. There were no clinically relevant changes in heart rate. Conclusions Empagliflozin is not associated with clinically relevant reflex-mediated sympathetic activation in contrast to increases observed with diuretics in other studies. Our study suggests a novel mechanism through which SGLT2 inhibition affects human autonomic cardiovascular regulation. Clinicaltrials.gov Identifier: NCT01276288.

      PubDate: 2017-07-23T14:20:28Z
      DOI: 10.1016/j.jash.2017.07.005
       
  • Celastrol synergizes with oral nifedipine to attenuate hypertension in
           preeclampsia: a randomized, placebo-controlled and double blinded trial
    • Authors: Sha Xiao; Ming Zhang; Yuan Liang; Deling Wang
      Abstract: Publication date: Available online 20 July 2017
      Source:Journal of the American Society of Hypertension
      Author(s): Sha Xiao, Ming Zhang, Yuan Liang, Deling Wang
      Preeclampsia, a disease mainly manifesting as serious hypertension during pregnancy, affects expectant mothers around the globe. Celastrol, a naturally existing triterpenoid, is known to exhibit beneficial effects attenuating cardiovascular symptoms including hypertension. We here assessed the treatment outcome against preeclampsia with a combined use of celastrol and nifedipine. 626 patients with preeclampsia were enrolled, screened, and assigned by random to groups receiving either nifedipine+placebo or nifedipine+celastrol orally. Time required to control hypertension as well as time before another hypertensive crisis were defined as primary endpoints. Secondary endpoints include the number of dosages required to control hypertension, as well as maternal and neonatal adverse effects. The time to control hypertension showed a marked reduction in nifedipine+celastrol group, while time before a new hypertensive crisis was significantly lengthened with the treatment, compared with the nifedipine+placebo group. The number of dosages required to control hypertension was also lower in the nifedipine+celastrol group. The two treatment groups were not statistically different regarding adverse effects, either maternal or neonatal. Results from the current study provides evidence for the potential role of celastrol serving as an effective and safe adjuvant to oral nifedipine against hypertension in patients with preeclampsia.

      PubDate: 2017-07-23T14:20:28Z
      DOI: 10.1016/j.jash.2017.07.004
       
  • No title
    • Authors: Daniel Levy
      Abstract: Publication date: Available online 17 July 2017
      Source:Journal of the American Society of Hypertension
      Author(s): Daniel Levy


      PubDate: 2017-07-23T14:20:28Z
       
  • Vitamin K2 Supplementation and Arterial Stiffness Among Renal Transplant
           Recipients – A Single-Arm, Single-Center Clinical Trial
    • Authors: Anthony Mansour; Essa Hariri; Yazan Daaboul; Serge Korjian; Andrew El Alam; Athanase D. Protogerou; Hala Kilany; Albert Karam; Antoine Stephan; Sola Aoun Bahous
      Abstract: Publication date: Available online 13 July 2017
      Source:Journal of the American Society of Hypertension
      Author(s): Anthony Mansour, Essa Hariri, Yazan Daaboul, Serge Korjian, Andrew El Alam, Athanase D. Protogerou, Hala Kilany, Albert Karam, Antoine Stephan, Sola Aoun Bahous
      Background Subclinical vitamin K deficiency is prevalent among renal transplant recipients and is associated with an increased risk of cardiovascular disease. However, the association between vitamin K supplementation and improvement of arterial stiffness has not been explored in the renal transplant population. Methods The KING trial (vitamin K2 In reNal Graft) is a single-arm study that evaluated the association between the change in vitamin K status and indices of arterial stiffness following 8 weeks of menaquinone-7 (vitamin K2) supplementation (360 μg once daily) among renal transplant recipients (n=60). Arterial stiffness was measured using carotid-femoral pulse wave velocity (cfPWV). Subclinical vitamin K deficiency was defined as plasma concentration of dephosphorylated-uncarboxylated Matrix Gla Protein (dp-ucMGP) > 500 pmol/L. Results At baseline, 53.3% of the study subjects had subclinical vitamin K deficiency. Supplementation was associated with a 14.2% reduction in mean cfPWV at 8 weeks (cfPWV pre-vitamin K2 = 9.8 ± 2.2 m/s vs. cfPWV post-vitamin K2 = 8.4 ± 1.5 m/s; p<0.001). Mean dp-ucMGP concentrations were also significantly reduced by 55.1% following menaquinone-7 supplementation with a reduction in the prevalence of subclinical deficiency by 40% (p=0.001). When controlled for age, durations of hemodialysis and transplantation, and the change in 24-hour mean arterial pressure, the improvement in arterial stiffness was independently associated with the reduction in dp-ucMGP concentration (p=0.014). Conclusions Among renal transplant recipients with stable graft function, vitamin K2 supplementation was associated with improvement in subclinical vitamin K deficiency and arterial stiffness. (Clinicaltrials.gov: NCT02517580).

      PubDate: 2017-07-23T14:20:28Z
      DOI: 10.1016/j.jash.2017.07.001
       
  • Inter-arm blood pressure difference in a post stroke population
    • Authors: E. Gaynor; L. Brewer; L. Mellon; P. Hall; N.F. Horgan; E. Shelley; E. Dolan; A. Hickey; K. Bennett; D.J. Williams
      Abstract: Publication date: Available online 4 July 2017
      Source:Journal of the American Society of Hypertension
      Author(s): E. Gaynor, L. Brewer, L. Mellon, P. Hall, N.F. Horgan, E. Shelley, E. Dolan, A. Hickey, K. Bennett, D.J. Williams
      Background An increased inter-arm systolic blood pressure difference of >10mmHg is associated with increased cardiovascular risk and a difference of >15mmHg with increased cerebrovascular risk. The stroke population presents a high-risk group for future cardiovascular and cerebrovascular events and therefore estimation of inter-arm SBP difference as a predictive tool may assist with further secondary stroke prevention. Objective To determine the prevalence of inter-arm systolic and diastolic blood pressure difference in a post stroke population. Methods A comprehensive assessment of secondary risk factors along with blood pressure measurements were taken 6-months’ post ischaemic stroke from the ASPIRE-S (Action on Secondary Prevention Interventions and Rehabilitation in Stroke cohort). Descriptive and logistic regression analyses were performed. Odds ratios and 95% Confidence intervals are presented Results 238 (M: F,139:99, mean age 68.4yrs) of 256 patients followed up at 6 months post stroke had suitable BP readings from both arms.40.3% (n=96) had an inter-arm systolic blood pressure difference of >10mmHg and 20.6% (n=49) had a difference of >15mmHg. A history of hypertension, diabetes, smoking and obesity was not significantly associated with an increased risk of inter-arm systolic blood pressure difference. After multivariate logistic analysis, a history of alcohol excess was associated with an increased IASBP >15mmHg (OR 2.32, 95% CI 1.03-5.22). Conclusion We have demonstrated that inter-arm systolic blood pressure difference is commonly seen in a post stroke population.

      PubDate: 2017-07-12T11:23:12Z
      DOI: 10.1016/j.jash.2017.06.008
       
  • Soluble endoglin (sEng) as a prognostic factor of the claudication
           distance improvement in patients with peripheral artery disease (PAD)
           undergoing supervised treadmill training program (STTP)
    • Authors: Rafał Januszek; Piotr Mika; Roman Nowobilski; Witold Nowak; Anna Kusienicka; Damian Klóska; Paweł Maga; Rafał Niżankowski
      Abstract: Publication date: Available online 28 June 2017
      Source:Journal of the American Society of Hypertension
      Author(s): Rafał Januszek, Piotr Mika, Roman Nowobilski, Witold Nowak, Anna Kusienicka, Damian Klóska, Paweł Maga, Rafał Niżankowski
      Conservative therapy after complete revascularization is increasing in popularity in patients with peripheral artery disease (PAD). The aim of the current study was to find determinants of the improvement of walking abilities and endothelial function in patients with PAD undergoing supervised treadmill training program (STTP). The presented study enclosed 66 patients in the mean age 65.4 ± 7.7 years with PAD who underwent a 3-month length STTP. We assessed the effect of following factors on the change of the flow-mediated dilatation value (ΔFMD), maximal-walking time (ΔMWT) and pain-free walking time (ΔPFWT). The evaluation included several biochemical and anthropometric indices with special insight into markers of angiogenesis, including soluble-endoglin (sEng), platelet-derived growth factor and angiopietin-2. Linear regression analysis (LRA) for each of the variables and multi-factorial model analysis of variances (ANOVA) was adopted to select the most influential determinants. The levels of sEng, a biomarker of several cardiovascular pathologies, were found to significantly predict the greater improvement of MWT and PFWT. Moreover, the LRA demonstrated, and ANOVA confirmed that coronary artery disease (CAD) and peracted endovascular interventions of lower limbs arteries (LLAs) are significant determinants of the better ΔFMD improvement. On the contrary, treatment with β-blockers and older age were poor predictors of ΔFMD increase. In conclusion, the sEng level could serve as a determinant of walking abilities change after STTP in patients with PAD. The treatment with β-blockers, the coexistence of CAD and peracted endovascular interventions of LLAs are determinants of endothelial function.

      PubDate: 2017-07-03T10:26:53Z
      DOI: 10.1016/j.jash.2017.06.009
       
  • White coat effect in hypertensive patients: the role of hospital
           environment or physician presence
    • Authors: Xi-xing Wang; Wei Shuai; Qiang Peng; Ju-xiang Li; Ping Li; Xiao-shu Cheng; Hai Su
      Abstract: Publication date: Available online 21 June 2017
      Source:Journal of the American Society of Hypertension
      Author(s): Xi-xing Wang, Wei Shuai, Qiang Peng, Ju-xiang Li, Ping Li, Xiao-shu Cheng, Hai Su
      Subject This study was to evaluate the role of hospital environment or physician presence for white coat effect (WCE) in hypertensive patients. Methods At first, 54 hypertensive outpatients diagnosed on office blood pressure (BP) were included for 2-week placebo run in. During the second week of the run in period, home BP (HBP) was measured using electronic BP monitors for 5-7 days. Finally, 26 sustained hypertensive patients with home SBP/DBP over 135/85 (but less than 180/110) mmHg were enrolled for 8-week treatment of nifedipine controlled-release tablet. In the visit day, BP was measured by patient-self (OBP-p) or by doctor (OBP-d) according to order determined with randomization method. The self BP measurement was performed in a reception room of hospital. The differences between HBP and OBP-d or OBP-p were calculated as WCE-d or WCE-p, respectively. The home and office BP were measured with the same BP device for each patient during the study period. Results In the total 54 outpatients received placebo, the WCE-d was similar to the WCE-p (for SBP 6.6±14.4 vs 6.8±15.8 mmHg, NS; for DBP 3.3±8.8 vs 2.9±9.2 mmHg, NS). Meanwhile, the 26 sustained hypertensive patients had similar systolic WCE-d and WCE-p (4.8±10.3 vs 5.0±12.2 mmHg, NS) at placebo stage. Similarly, these values were comparable (3.0±14.0 vs 2.2±14.4mmHg, NS) in treatment stage. Conclusion Hospital environment plays a main role for the white coat effect in hypertensive patients.

      PubDate: 2017-06-22T08:07:42Z
      DOI: 10.1016/j.jash.2017.06.006
       
  • Visit-to-Visit Variability of Blood Pressure
    • Authors: John B. Kostis
      Abstract: Publication date: Available online 20 June 2017
      Source:Journal of the American Society of Hypertension
      Author(s): John B. Kostis


      PubDate: 2017-06-22T08:07:42Z
      DOI: 10.1016/j.jash.2017.06.005
       
  • Systemic and tissue-specific effects of aliskiren on the RAAS and
           carbohydrate/lipid metabolism in obese patients with hypertension
    • Authors: Stefan Engeli; Marcus May; Juerg Nussberger; A. H. Jan Danser; William P. Dole; Margaret F. Prescott; Marion Dahlke; Sylvie Stitah; Parasar Pal; Michael Boschmann; Jens Jordan
      Abstract: Publication date: Available online 12 June 2017
      Source:Journal of the American Society of Hypertension
      Author(s): Stefan Engeli, Marcus May, Juerg Nussberger, A. H. Jan Danser, William P. Dole, Margaret F. Prescott, Marion Dahlke, Sylvie Stitah, Parasar Pal, Michael Boschmann, Jens Jordan
      Aliskiren penetrates adipose and skeletal muscle in hypertensive patients with abdominal obesity and reduces renin-angiotensin-aldosterone system activity. After discontinuation, blood-pressure–lowering effects are observed possibly through drug–tissue binding. We performed microdialysis evaluation of adipose tissue and skeletal muscle before and during an insulin-modified frequently sampled intravenous glucose tolerance test (IM-FSIGT). Aliskiren 300 mg (n=8) or amlodipine 5 mg (n=8) once daily were administered during a 12-week randomized treatment period. Aliskiren elicited variable changes in median interstitial angiotensin II in adipose (2.60 to 1.30 fmol/mL) and skeletal muscle (2.23 to 0.68 fmol/mL); amlodipine tended to increase adipose and skeletal muscle angiotensin II (p=0.066 for skeletal muscle treatment difference). Glucose/insulin increased median plasma angiotensin II 1 hour after glucose injection (1.04 to 2.50 fmol/mL; p=0.001), which was markedly attenuated by aliskiren but not amlodipine. Aliskiren increased glucose disposition index (p=0.012) and tended to increase acute insulin response to glucose (p=0.067). Fasting adipose glycerol (−17%; p=0.064) and fasting muscle glucose dialysate (−17%; p=0.025) were decreased by aliskiren but not amlodipine. In summary, aliskiren decreased angiotensin II production in response to glucose/insulin stimulus and elicited metabolic effects in adipose and skeletal muscle suggestive of increased whole-body glucose utilization.

      PubDate: 2017-06-16T07:37:07Z
      DOI: 10.1016/j.jash.2017.06.002
       
  • Large geographic disparity in life expectancy may be driven by rates of
           hypertension and related metabolic and behavioral parameters
    • Authors: Michael J. Bloch
      Abstract: Publication date: Available online 8 June 2017
      Source:Journal of the American Society of Hypertension
      Author(s): Michael J. Bloch


      PubDate: 2017-06-12T07:11:50Z
      DOI: 10.1016/j.jash.2017.05.004
       
  • Severe and Resistant Hypertension in an Older Woman with Claudication
    • Authors: Puneet Gupta; Robert Hagberg; Electra Kaloudis; Anika Lucas; Parth Shah; William B. White
      Abstract: Publication date: Available online 1 June 2017
      Source:Journal of the American Society of Hypertension
      Author(s): Puneet Gupta, Robert Hagberg, Electra Kaloudis, Anika Lucas, Parth Shah, William B. White
      Coarctation of the aorta is an uncommon cause of treatment resistant hypertension in adults. It is typically detected and treated in infancy or childhood with surgical or endovascular procedures. Most cases of recurrence of coarctation after repair occur in childhood or early adulthood; recurrence in older persons (> 70 years) has rarely been reported. A 73 year old woman was referred to us for the management of treatment resistant hypertension accompanied by symptoms of claudication and headaches, which had resulted in multiple emergency room visits. Of note, 58 years earlier, a graft from the left subclavian artery had been used to bypass an aortic coarctation. During a hospitalization for severe hypertension accompanied by acute kidney injury and heart failure, diagnostic angiography revealed a complete thrombotic occlusion of the left subclavian artery-to-descending aorta bypass graft and a tight coarctation in the descending thoracic aorta. Balloon angioplasty and stenting across the coarctation was only transiently effective; subsequently an ascending-to-descending graft was placed distal to the coarctation and within a few days, the blood pressure levels and claudication improved markedly. This case demonstrates that hypertension specialists should suspect the possibility of recurrence of a coarctation in older patients who present with resistant hypertension and have a remote history of coarctation repair. Although such late recurrences are not common, as illustrated in our patient, surgical intervention may contribute to significant improvement in blood pressure control and prevent future complications.

      PubDate: 2017-06-02T05:37:49Z
      DOI: 10.1016/j.jash.2017.05.007
       
 
 
JournalTOCs
School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
Email: journaltocs@hw.ac.uk
Tel: +00 44 (0)131 4513762
Fax: +00 44 (0)131 4513327
 
Home (Search)
Subjects A-Z
Publishers A-Z
Customise
APIs
Your IP address: 23.20.86.177
 
About JournalTOCs
API
Help
News (blog, publications)
JournalTOCs on Twitter   JournalTOCs on Facebook

JournalTOCs © 2009-2016