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  Subjects -> HISTORY (Total: 1280 journals)
    - HISTORY (816 journals)
    - History (General) (51 journals)
    - HISTORY OF AFRICA (49 journals)
    - HISTORY OF ASIA (53 journals)
    - HISTORY OF AUSTRALASIA AREAS (7 journals)
    - HISTORY OF EUROPE (161 journals)
    - HISTORY OF THE AMERICAS (117 journals)
    - HISTORY OF THE NEAR EAST (26 journals)

HISTORY (816 journals)            First | 1 2 3 4 5     

Showing 601 - 452 of 452 Journals sorted alphabetically
Pilipinas: A Journal of Philippine Studies     Full-text available via subscription   (Followers: 1)
Pleine Marge     Full-text available via subscription   (Followers: 1)
PLURA, Revista de Estudos de Religião / PLURA, Journal for the Study of Religion     Open Access   (Followers: 2)
Policy and Society     Hybrid Journal   (Followers: 4)
Polis : The Journal of the Society for Greek Political Thought     Hybrid Journal   (Followers: 5)
Politics & Society     Hybrid Journal   (Followers: 26)
Politikon: South African Journal of Political Studies     Hybrid Journal   (Followers: 2)
Politique et Sociétés     Full-text available via subscription  
Popular Music History     Hybrid Journal   (Followers: 10)
positions : asia critique     Full-text available via subscription   (Followers: 5)
Postcolonial Directions in Education     Open Access   (Followers: 1)
Postcolonial Studies     Hybrid Journal   (Followers: 10)
Postcolonial Text     Open Access   (Followers: 7)
Préhistoires méditerranéennes     Open Access   (Followers: 2)
Proceedings of the Aristotelian Society (hardback)     Hybrid Journal   (Followers: 3)
Proceedings of the Institution of Civil Engineers - Engineering History and Heritage     Hybrid Journal   (Followers: 3)
Proceedings of the Linnean Society of New South Wales     Full-text available via subscription   (Followers: 1)
Proceedings of the Prehistoric Society     Hybrid Journal   (Followers: 8)
Proceedings of the Royal Society of Queensland, The     Full-text available via subscription   (Followers: 1)
Proceedings of the Zoological Society     Hybrid Journal   (Followers: 2)
Procesos Historicos     Open Access  
Prose Studies: History, Theory, Criticism     Hybrid Journal   (Followers: 3)
Psychoanalysis and History     Hybrid Journal   (Followers: 1)
Psychoanalysis Culture & Society     Hybrid Journal   (Followers: 6)
Publications du Centre Européen d'Etudes Bourguignonnes     Full-text available via subscription  
Purdue Historian     Open Access  
Quaderns d’Història de l’Enginyeria     Open Access  
Quaker History     Full-text available via subscription   (Followers: 6)
Queensland Naturalist     Full-text available via subscription  
Queensland Review     Full-text available via subscription  
Questes : Revue pluridisciplinaire d'études médiévales     Open Access  
Quintana. Revista de Estudos do Departamento de Historia da Arte     Open Access  
Radical History Review     Full-text available via subscription   (Followers: 17)
Rasenna : Journal of the Center for Etruscan Studies     Open Access   (Followers: 1)
Rationality and Society     Hybrid Journal   (Followers: 4)
Raven : A Journal of Vexillology     Hybrid Journal  
Reinardus     Hybrid Journal  
Relaciones. Estudios de historia y sociedad     Open Access  
Renaissance Drama     Full-text available via subscription   (Followers: 5)
Renaissance Quarterly     Full-text available via subscription   (Followers: 34)
Renaissance Studies     Hybrid Journal   (Followers: 17)
Rethinking History: The Journal of Theory and Practice     Hybrid Journal   (Followers: 23)
Reti Medievali Rivista     Open Access   (Followers: 2)
Review of Central and East European Law     Hybrid Journal   (Followers: 8)
Reviews in American History     Full-text available via subscription   (Followers: 12)
Revista Análisis Internacional     Open Access  
Revista Brasileira de Historia     Open Access   (Followers: 3)
Revista Chilena de Historia del Derecho     Open Access  
Revista de Estudios Historico-Juridicos     Open Access   (Followers: 1)
Revista de História     Open Access  
Revista de História da UEG     Open Access  
Revista Historia Autónoma     Open Access  
Revista História da Educação - History of Education Journal     Open Access  
Revista Maracanan     Open Access  
Revista Trías     Open Access  
Revolutionary Russia     Hybrid Journal   (Followers: 7)
Revue archéologique de l'Est     Open Access   (Followers: 3)
Revue archéologique du Centre de la France     Open Access   (Followers: 2)
Revue d'histoire de l'Amérique française     Full-text available via subscription   (Followers: 1)
Revue d'Histoire de l'Eglise de France     Full-text available via subscription   (Followers: 3)
Revue d'histoire de l'enfance     Open Access  
Revue d'Histoire des Textes     Full-text available via subscription  
Revue d'histoire du XIXe siècle     Open Access   (Followers: 6)
Revue d'Histoire Ecclésiastique     Full-text available via subscription  
Revue de l’Histoire des Religions     Open Access   (Followers: 11)
Revue des Études Arméniennes     Full-text available via subscription   (Followers: 1)
Revue historique des armées     Open Access   (Followers: 2)
Revue Mabillon     Full-text available via subscription   (Followers: 6)
Rhetoric Society Quarterly     Hybrid Journal   (Followers: 13)
RIHA Journal     Open Access   (Followers: 5)
RIMA: Review of Indonesian and Malaysian Affairs     Full-text available via subscription   (Followers: 1)
Romanticism     Hybrid Journal   (Followers: 4)
Romanticism and Victorianism on the Net     Open Access   (Followers: 6)
Royal Studies Journal     Open Access  
Rúbrica Contemporánea     Open Access  
Rural History     Hybrid Journal   (Followers: 14)
Russian Education & Society     Full-text available via subscription   (Followers: 4)
Russian History     Hybrid Journal   (Followers: 12)
Russian Review     Hybrid Journal   (Followers: 17)
Sacris Erudiri     Full-text available via subscription   (Followers: 6)
Saeculum : Jahrbuch für Universalgeschichte     Hybrid Journal  
Safundi : The Journal of South African and American Studies     Hybrid Journal   (Followers: 1)
Scandinavian Journal of History     Hybrid Journal   (Followers: 13)
Scando-Slavica     Hybrid Journal   (Followers: 4)
Science & Society     Full-text available via subscription   (Followers: 3)
Science Journal of Volgograd State University. History. Area Studies. International Relations     Open Access  
Scientia Canadensis: Canadian Journal of the History of Science, Technology and Medicine / Scientia Canadensis : revue canadienne d'histoire des sciences, des techniques et de la médecine     Full-text available via subscription   (Followers: 4)
Scientia Militaria : South African Journal of Military Studies     Open Access   (Followers: 5)
Scientiae Studia     Open Access  
Scottish Historical Review     Hybrid Journal   (Followers: 15)
Scrineum Rivista     Open Access  
Scrutiny2: Issues in English Studies in Southern Africa     Hybrid Journal   (Followers: 1)
Senses and Society     Hybrid Journal   (Followers: 4)
Sibirica     Full-text available via subscription  
Siècles     Open Access  
Signals     Full-text available via subscription   (Followers: 2)
Signos Historicos     Open Access  
Slagmark - Tidsskrift for idéhistorie     Open Access   (Followers: 2)
Slavery & Abolition: A Journal of Slave and Post-Slave Studies     Hybrid Journal   (Followers: 7)
Slavonica     Hybrid Journal   (Followers: 3)
Social History     Hybrid Journal   (Followers: 38)
Social History of Medicine     Hybrid Journal   (Followers: 14)
Social Science History     Full-text available via subscription   (Followers: 10)
Social Sciences and Missions     Hybrid Journal   (Followers: 3)
Società e Storia     Full-text available via subscription   (Followers: 1)
Society     Hybrid Journal   (Followers: 5)
Society and Economy     Full-text available via subscription   (Followers: 2)
SourceOECD National Accounts & Historical Statistics     Full-text available via subscription  
South African Historical Journal     Hybrid Journal   (Followers: 5)
South African Journal of Art History     Full-text available via subscription   (Followers: 2)
South African Journal of Cultural History     Full-text available via subscription  
South African Journal of Economic History     Full-text available via subscription   (Followers: 2)
South Asia Research     Hybrid Journal   (Followers: 8)
South Asia: Journal of South Asian Studies     Hybrid Journal   (Followers: 11)
South Asian History and Culture     Hybrid Journal   (Followers: 3)
South Asian Popular Culture     Hybrid Journal   (Followers: 2)
South Asian Survey     Hybrid Journal   (Followers: 4)
South Australian Naturalist, The     Full-text available via subscription  
South Central Review     Full-text available via subscription  
South European Society and Politics     Hybrid Journal   (Followers: 8)
Southeast European and Black Sea Studies     Hybrid Journal   (Followers: 4)
Southwestern Historical Quarterly     Full-text available via subscription   (Followers: 5)
Soviet and Post-Soviet Review     Hybrid Journal   (Followers: 8)
Spontaneous Generations : A Journal for the History and Philosophy of Science     Open Access   (Followers: 1)
Sport in History     Hybrid Journal   (Followers: 7)
Stewart Postharvest Review     Full-text available via subscription  
Studia Aurea : Revista de Literatura Española y Teoría Literaria del Renacimiento y Siglo de Oro     Open Access   (Followers: 1)
Studia Historiae Ecclesiasticae     Open Access   (Followers: 2)
Studia Historiae Oeconomicae     Open Access  
Studia Iranica     Full-text available via subscription   (Followers: 3)
Studia Litteraria et Historica     Open Access  
Studia z Historii Filozofii     Open Access  
Studies in East European Thought     Hybrid Journal   (Followers: 6)
Studies in Eighteenth Century Culture     Full-text available via subscription   (Followers: 17)
Studies in History     Hybrid Journal   (Followers: 23)
Studies in History and Philosophy of Science Part A     Hybrid Journal   (Followers: 4)
Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences     Hybrid Journal   (Followers: 11)
Studies in the History of Gardens & Designed Landscapes: An International Quarterly     Hybrid Journal   (Followers: 7)
Studies in Western Australian History     Full-text available via subscription   (Followers: 3)
Studium : Tijdschrift voor Wetenschaps- en Universiteits-geschiedenis / Revue d'Histoire des Sciences et des Universités     Open Access   (Followers: 1)
Sydney Institute Quarterly     Full-text available via subscription  
T'oung Pao     Hybrid Journal   (Followers: 9)
Tangence     Full-text available via subscription  
Tasmanian Historical Studies     Full-text available via subscription   (Followers: 1)
Teaching History     Full-text available via subscription   (Followers: 5)
Technology and Culture     Full-text available via subscription   (Followers: 21)
temp - tidsskrift for historie     Full-text available via subscription  
Tempo     Open Access   (Followers: 2)
Tempo e Argumento     Open Access  
The Americas : A Quarterly Review of Latin American History     Full-text available via subscription   (Followers: 6)
The Court Historian : The International Journal of Court Studies     Full-text available via subscription  
The Eighteenth Century     Full-text available via subscription   (Followers: 25)
The European Legacy: Toward New Paradigms     Hybrid Journal   (Followers: 2)
The Hilltop Review : A Journal of Western Michigan University Graduate Student Research     Open Access  
The Historian     Hybrid Journal   (Followers: 34)
The International History Review     Hybrid Journal   (Followers: 20)
The Irish Review     Full-text available via subscription   (Followers: 14)
The Italianist     Hybrid Journal   (Followers: 5)
The Journal of the Historical Society     Hybrid Journal   (Followers: 12)
The Public Historian     Full-text available via subscription   (Followers: 7)
The Seventeenth Century     Hybrid Journal   (Followers: 13)
The Sixties: A Journal of History, Politics and Culture     Hybrid Journal   (Followers: 9)
The South African Journal of Economics     Hybrid Journal   (Followers: 3)
Theatre History Studies     Full-text available via subscription   (Followers: 3)
Theoria et Historia Scientiarum     Open Access  
Tiempo y Espacio     Open Access  
Tijdschrift voor Geschiedenis     Full-text available via subscription   (Followers: 1)
Tijdschrift voor Rechtsgeschiedenis / Revue d'Histoire du Droit / The Legal History Review     Hybrid Journal   (Followers: 19)
Time & Society     Hybrid Journal   (Followers: 10)
Trabajos y Comunicaciones     Open Access  
Traditio     Full-text available via subscription   (Followers: 1)
Transactions of the Philological Society     Hybrid Journal   (Followers: 2)
Transactions of the Royal Historical Society     Hybrid Journal   (Followers: 14)
Transactions of the Royal Society of South Africa     Hybrid Journal   (Followers: 2)
Transfers     Full-text available via subscription  
Transition     Full-text available via subscription   (Followers: 1)
Transmodernity : Journal of Peripheral Cultural Production of the Luso-Hispanic World     Open Access   (Followers: 3)
Trocadero     Open Access  
Troianalexandrina     Full-text available via subscription   (Followers: 1)
Turcica     Full-text available via subscription   (Followers: 8)
Turkish Historical Review     Hybrid Journal   (Followers: 5)
Turkish Studies     Hybrid Journal   (Followers: 8)
Twentieth Century British History     Hybrid Journal   (Followers: 17)
U.S. Catholic Historian     Full-text available via subscription   (Followers: 2)
UCLA Historical Journal     Open Access  
Ufahamu : A Journal of African Studies     Open Access   (Followers: 1)
United Service     Full-text available via subscription   (Followers: 2)
Urban History     Hybrid Journal   (Followers: 18)
Urban History Review / Revue d'histoire urbaine     Full-text available via subscription   (Followers: 4)
Varia Historia     Open Access   (Followers: 2)
Vegueta : Anuario de la Facultad de Geografía e Historia     Open Access  
Vestiges : Traces of Record     Full-text available via subscription  
Viator     Full-text available via subscription   (Followers: 11)
Victorian Naturalist, The     Full-text available via subscription   (Followers: 3)
Victorian Periodicals Review     Full-text available via subscription   (Followers: 6)
Vigiliae Christianae     Hybrid Journal   (Followers: 11)
Viking and Medieval Scandinavia     Full-text available via subscription   (Followers: 14)
Vínculos de Historia. Revista del Departamento de Historia de la Universidad de Castilla-La Mancha     Open Access  
Visual Resources: An International Journal of Documentation     Hybrid Journal   (Followers: 1)
Vivarium     Hybrid Journal   (Followers: 2)

  First | 1 2 3 4 5     

Journal Cover Journal of the American Society of Hypertension
  [SJR: 1.15]   [H-I: 22]   [7 followers]  Follow
    
   Hybrid Journal Hybrid journal (It can contain Open Access articles)
   ISSN (Print) 1933-1711
   Published by Elsevier Homepage  [2970 journals]
  • Lower is better in hypertension, but how low should blood pressure be
           targeted?
    • Abstract: Publication date: Available online 18 June 2016
      Source:Journal of the American Society of Hypertension
      Author(s): Rhian M. Touyz



      PubDate: 2016-06-18T18:35:39Z
       
  • Important practice lessons from the SPRINT study beyond the blood pressure
           goal: All well-known and now confirmed
    • Abstract: Publication date: Available online 16 June 2016
      Source:Journal of the American Society of Hypertension
      Author(s): George S. Stergiou, Michael Doumas, Anastasios Kollias, Vasilios Papademetriou



      PubDate: 2016-06-18T18:35:39Z
       
  • Significance of adjusting salt intake by body weight in the evaluation of
           dietary salt and blood pressure
    • Abstract: Publication date: Available online 18 June 2016
      Source:Journal of the American Society of Hypertension
      Author(s): Tomomi Hashimoto, Hiroyuki Takase, Tateo Okado, Tomonori Sugiura, Sumiyo Yamashita, Genjiro Kimura, Nobuyuki Ohte, Yasuaki Dohi
      The close association between dietary salt and hypertension is well established. However, previous studies generally assessed salt intake without adjustment for body weight. Herein, we investigated the significance of body weight-adjusted salt intake in the general population. The present cross-sectional study included 7,629 participants from our yearly physical checkup program and their salt intake was assessed using a spot urine test to estimate 24-hour urinary salt excretion. Total salt intake increased with increasing body weight. Body weight-adjusted salt intake was greater in participants with hypertension than in those without hypertension. Systolic blood pressure, estimated glomerular filtration rate, and urinary albumin were independently correlated with body weight-adjusted salt intake after adjustment for possible cardiovascular risk factors. Excessive body weight-adjusted salt intake could be related to an increase in blood pressure and hypertensive organ damage. Adjustment for body weight might therefore provide clinically important information when assessing individual salt intake.


      PubDate: 2016-06-18T18:35:39Z
       
  • Decision sharing in preventive cardiology
    • Abstract: Publication date: Available online 24 May 2016
      Source:Journal of the American Society of Hypertension
      Author(s): Lawrence R. Krakoff



      PubDate: 2016-06-16T18:07:20Z
       
  • Renal denervation significantly attenuates cardiorenal fibrosis in rats
           with sustained pressure overload
    • Abstract: Publication date: Available online 24 May 2016
      Source:Journal of the American Society of Hypertension
      Author(s): Qian Liu, Dasheng Lu, Shengchan Wang, Kai Wang, Qi Zhang, Ying Wang, Ping Fang, Zhenzhen Li, Jie Geng, Qijun Shan
      To investigate the effects of renal denervation (RDN) on comprehensive cardiac and renal fibrosis in cardiomyopathy. Five weeks after successful transverse aortic constriction (TAC)–induced cardiomyopathy model building, Sprague-Dawley rats were randomly assigned to three groups: (1) RDN, (2) sham, and (3) losartan. Sham TAC rats served as control group. Compared with control, TAC groups showed a significant decrease in left ventricle ejection fraction and increase in ventricular septum thickness and left atrium diameter on echocardiography after 5 weeks. At 10 weeks post-TAC, venous blood samples were collected for fibrosis biochemical assay. Heart and kidney samples were also harvested for fibrosis pathophysiological detection. Cardiac and renal fibrosis quantity results showed that, compared with sham group, collagen volume fraction was significantly decreased in RDN group more than in losartan group. Biochemical parameters such as tumor necrosis factor α, aldosterone, and B-type natriuretic peptide levels as well as biomarkers for fibrosis such as procollagen type I N-terminal propeptide and procollagen type III N-terminal propeptide concentrations were significantly decreased in RDN group in comparison with sham. In addition, compared with sham group, left ventricle tissue protein expression of transforming growth factor-β1 and angiotensin II type I receptor was downregulated, and angiotensin-converting enzyme 2 was upregulated in RDN but not in losartan group. RDN significantly attenuates cardiac and renal fibrosis in cardiomyopathy. Differing from losartan, which only has angiotensin II type I receptor inhibition effects, RDN comprehensively suppresses cardiac and renal fibrogenesis through multiple pathways.


      PubDate: 2016-06-16T18:07:20Z
       
  • Is there an association between the prevalence of atrial fibrillation and
           severity and control of hypertension? The REasons for Geographic And
           Racial Differences in Stroke (REGARDS) study
    • Abstract: Publication date: Available online 30 May 2016
      Source:Journal of the American Society of Hypertension
      Author(s): Hemal Bhatt, Christopher M. Gamboa, Monika M. Safford, Elsayad Soliman, Stephen P. Glasser
      Background The association of atrial fibrillation (AF) with the severity and control of hypertension (HTN) remains unclear. Methods We analyzed data from the national biracial cohort of REasons for Geographic And Racial Differences in Stroke (REGARDS) study. The AF prevalence ratios were estimated and full multi-variable adjustment included demographics, risk factors, medication adherence, HTN duration and antihypertensive medication classes. Results Of the 30,018 study participants (8.6% with AF), 4,386 had normotension (4.3% with AF), 5,916 had prehypertension (4.3 with AF%), 12,294 had controlled HTN (11.2% with AF), 5,587 had uncontrolled HTN (8.1% with AF), 547 had controlled apparent treatment resistant hypertension (aTRH) (19.2% with AF), and 1288 had uncontrolled aTRH (15.5% with AF). Compared with normotension, the AF prevalence ratios for prehypertension, controlled HTN, uncontrolled HTN, controlled aTRH and uncontrolled aTRH groups in fully adjusted model were 1.01 (95% CI 0.84 – 1.21), 1.42 (1.18 – 1.71), 1.37 (1.14 – 1.65), 1.17 (0.86 – 1.58) and 1.42 (1.10 – 1.84) respectively (p < 0.001). Conclusion The prevalence of AF was similar among persons with HTN regardless of BP level and antihypertensive treatment resistance.


      PubDate: 2016-06-16T18:07:20Z
       
  • Instructions for Authors
    • Abstract: Publication date: June 2016
      Source:Journal of the American Society of Hypertension, Volume 10, Issue 6




      PubDate: 2016-06-16T18:07:20Z
       
  • Spironolactone and glucose metabolism, a systematic review and
           meta-analysis of randomized controlled trials
    • Abstract: Publication date: Available online 9 June 2016
      Source:Journal of the American Society of Hypertension
      Author(s): Jie V. Zhao, Lin Xu, Shi Lin Lin, C Mary Schooling
      Diabetes predicts cardiovascular disease (CVD); some drugs are effective for CVD prevention but increase the risk of diabetes. In a systematic review and meta-analysis of placebo-controlled trials we assessed if spironolactone, a mineralocorticoid receptor antagonist, affected glycemic control. We searched PubMed using (“spironolactone” or “aldactone”) and trial and (“glucose” or “diabetes” or “insulin” or “insulin resistance”) from March 3, 2015 to January 4, 2016. In total, 18 eligible trials were identified; 10 on fasting glucose, 8 on hemoglobin A1c (HbA1c), 7 on homeostatic model assessment (HOMA)-insulin resistance (IR) and 8 on insulin. Spironolactone increased HbA1c (0.16%, 95% confidence interval 0.02 to 0.30), but had no clear effect on fasting glucose, HOMA-IR and insulin. A mechanistic randomized controlled trial in people with and without diabetes might provide insight concerning these pleiotropic effects on diabetes and CVD relevant to prevention of both diseases.


      PubDate: 2016-06-16T18:07:20Z
       
  • Hypertension in the frail elderly
    • Abstract: Publication date: June 2016
      Source:Journal of the American Society of Hypertension, Volume 10, Issue 6
      Author(s): Barry J. Materson, Manuel Garcia-Estrada, Richard A. Preston
      Extant data indicate that treating to lower systolic pressure confers significant advantage to younger people in general good health and to relatively healthy octogenarians. Few data exist to guide practitioners on the treatment of frail elderly hypertensives. Chronological age alone does not suffice to make useful judgments regarding therapy. The definition of frailty remains controversial. One method, use of a simple questionnaire or a test of walking speed is practical but not universally accepted. Frail subjects, while at higher risk for cardiovascular complications, seem to benefit less or not at all from antihypertensive drug treatment. Clinicians should treat robust older patients as they would younger patients because the benefits far outweigh the low risk of adverse effects. Successful antihypertensive therapy in those younger than 80 years should not be discontinued simply because that age milestone has been crossed. Treatment of frail older patients must be individualized. Some frail survivors age 80 years or older may actually fare better with elevated systolic pressures. Pending the cognitive function substudy of Systolic Blood Pressure Intervention Trial, there is little evidence that antihypertensive treatment benefits established cognitive dysfunction. Because hypertension in middle age is a good predictor of later cognitive dysfunction, the clinical approach should be one of early prevention.


      PubDate: 2016-06-16T18:07:20Z
       
  • Editorial Board
    • Abstract: Publication date: June 2016
      Source:Journal of the American Society of Hypertension, Volume 10, Issue 6




      PubDate: 2016-06-16T18:07:20Z
       
  • Table of Contents
    • Abstract: Publication date: June 2016
      Source:Journal of the American Society of Hypertension, Volume 10, Issue 6




      PubDate: 2016-06-16T18:07:20Z
       
  • Prevalence of pseudoresistant hypertension due to inaccurate blood
           pressure measurement
    • Abstract: Publication date: June 2016
      Source:Journal of the American Society of Hypertension, Volume 10, Issue 6
      Author(s): Hemal Bhatt, Mohammed Siddiqui, Eric Judd, Suzanne Oparil, David Calhoun
      The prevalence of pseudoresistant hypertension (HTN) due to inaccurate BP measurement remains unknown. Triage BP measurements and measurements obtained at the same clinic visit by trained physicians were compared in consecutive adult patients referred for uncontrolled resistant HTN (RHTN). Triage BP measurements were taken by the clinic staff during normal intake procedures. BP measurements were obtained by trained physicians using the BpTRU (VSM Med Tech Ltd. Coquitlam, Canada) device. The prevalence of uncontrolled RHTN and differences in BP measurements were compared. Of 130 patients with uncontrolled RHTN, 33.1% (n = 43) were falsely identified as having uncontrolled RHTN based on triage BP measurements. The median (inter-quartile range) of differences in systolic BP between pseudoresistant and true resistant groups were 23 (17–33) mm Hg and 13 (6–21) mm Hg, respectively (P = .0001). The median (inter-quartile range) of differences in diastolic BP between the two groups were 12 (7–18) mm Hg and 8 (4–11) mm Hg, respectively (P = .001). Triage BP technique overestimated the prevalence of uncontrolled RHTN in approximately 33% of the patients emphasizing the importance of obtaining accurate BP measurements.


      PubDate: 2016-06-16T18:07:20Z
       
  • Symmetric ambulatory arterial stiffness index in the young
    • Abstract: Publication date: June 2016
      Source:Journal of the American Society of Hypertension, Volume 10, Issue 6
      Author(s): Minh B. Nguyen, Pamela Singer, Fredrick Kaskel, Joseph Mahgerefteh
      The ambulatory arterial stiffness index (AASI) and the symmetric ambulatory arterial stiffness index (s-AASI) have been shown to correlate to arterial stiffness in adults. This study assesses these indices with anthropometric and blood pressure (BP) measures in children. A total of 102 children at a pediatric hypertension clinic who had ambulatory blood pressure monitoring (ABPM) done from 2009 to 2013 were included (75% males, 7-22yo, 47% hypertensive, 24% prehypertensive, and 34% white-coat hypertensives). AASI is 1 minus the regression slope of diastolic BP values on systolic BP values from a 24-hour ambulatory blood pressure monitoring. s-AASI is the symmetric regression of AASI. Obese patients had a significantly higher AASI. s-AASI correlated with systolic BP variability. In multivariable regression, BP variability independently correlated with AASI and s-AASI. s-AASI is related to systolic dipping.AASI and s-AASI are highly dependent on BP variability in children. Further studies are necessary to assess their utility.


      PubDate: 2016-06-16T18:07:20Z
       
  • Renal denervation in the era of HTN-3. Comprehensive review and glimpse
           into the future
    • Abstract: Publication date: Available online 2 June 2016
      Source:Journal of the American Society of Hypertension
      Author(s): Joana Delgado Silva, Marco Costa, Bernard J. Gersh, Lino Gonçalves
      The pathophysiologic role of sympathetic overactivity in conditions such as hypertension has been well documented. [1] Catheter-based renal denervation (RDN) is a minimally invasive percutaneous procedure which aims to disrupt sympathetic nerve afferent and efferent activity through the application of radiofrequency energy directly within the renal artery wall. This technique has emerged as a very promising treatment with dramatic effects upon refractory hypertension but also in other conditions in which a sympathetic influence is present. Several studies have evaluated the safety and efficacy of this procedure, presently surrounded by controversy since the recent outcome of Symplicity HTN-3, the first randomized, sham-control trial, which failed to confirm RDN previous reported benefits on BP and cardiovascular risk lowering. Consequently, although some centers halted their RDN programs, research continues and both the concept of denervation and treatment strategies are being redefined in order to identify patients who can drive the most benefit from this technology. In the United States, The FDA has appropriately mandated that RDN remains an investigative procedure and a new generation of sham controlled trials are ongoing and aimed to assess not only its efficacy against pharmacotherapy but also trials in drug free patients with the objective of demonstrating once and for all whether the procedure actually does lower BP in comparison to a placebo arm. In this article, we present an overview of the sympathetic nervous system and its role in hypertension, examine the current data on RDN and share some insights and future expectations.


      PubDate: 2016-06-16T18:07:20Z
       
  • From the Editor
    • Abstract: Publication date: Available online 3 June 2016
      Source:Journal of the American Society of Hypertension
      Author(s): Daniel Levy



      PubDate: 2016-06-16T18:07:20Z
       
  • Hypertension and Alterations in Left Ventricular Structure and Geometry in
           African Americans: The Jackson Heart Study
    • Abstract: Publication date: Available online 2 June 2016
      Source:Journal of the American Society of Hypertension
      Author(s): Marwah Abdalla, John N. Booth, Keith M. Diaz, Mario Sims, Paul Muntner, Daichi Shimbo
      African Americans (AAs) have an increased risk for hypertension-related cardiovascular outcomes compared with Whites, which may be related to abnormal left ventricular (LV) structure. We examined the association of prevalent hypertension with concentric remodeling (CR: normal LV mass index [LVMI] and increased relative wall thickness: RWT), eccentric hypertrophy (EH: increased LVMI and normal RWT), and concentric hypertrophy (CH: increased LVMI and increased RWT) within the Jackson Heart Study. Among 4,721 participants (mean ± SD age 55.7±12.7 years), 2,841 (60.2%) had prevalent hypertension, defined as mean clinic BP ≥140/90mmHg or antihypertensive medication use. Prevalent hypertension was associated with a statistically significantly increased odds for having CR (odds ratio [OR] 1.78 95% confidence interval CI: 1.42-2.24), EH (OR 1.68 95%CI: 1.15-2.44), and CH (OR 3.86 95%CI: 2.28-6.54) after multivariable adjustment. In conclusion, in a population-based sample of AAs, hypertension was associated with an increased odds for having abnormal LV structure, particularly CH.


      PubDate: 2016-06-16T18:07:20Z
       
  • Vitamin D depletion does not affect key aspects of the preeclamptic
           phenotype in a transgenic rodent model for preeclampsia
    • Abstract: Publication date: Available online 4 June 2016
      Source:Journal of the American Society of Hypertension
      Author(s): Louise Bjørkholt Andersen, Michaela Golic, Lukasz Przybyl, Grith Lykke Sorensen, Jan Stener Jørgensen, Palle Fruekilde, Frauke von Versen-Höynck, Florian Herse, Carsten Schriver Højskov, Ralf Dechend, Henrik Thybo Christesen, Nadine Haase
      Maternal vitamin D deficiency is proposed as a risk factor for preeclampsia in humans. We tested the hypothesis that vitamin D depletion aggravates and high supplementation ameliorates the preeclampsia phenotype in an established transgenic rat model of human renin-angiotensin system (RAS) mediated preeclampsia. Methods Adult rat dams, transgenic for human angiotensinogen (hAGT) and mated with male rats transgenic for human renin (hREN), were fed either vitamin D-depleted chow (VDd) or enriched chow (VDh) two weeks before mating and during pregnancy. Mean blood pressure was recorded by tail-cuff, and 24-hour urine samples were collected in metabolic cages at days 6 and 18 of gestation. Rats were sacrificed at day 21 of gestation. Results Depleted dams (VDd) had negligible serum 25-hydroxyvitamin D2+3 levels (mean±SEM; 2.95±0.45 nmol/l vs. VDh 26.20±2.88 nmol/l, p=0.01), but in both groups, levels of 1,25(OH)2D3 remained below detection level of 25 pmol/l. Dietary vitamin D depletion did not aggravate hypertension (mean±SEM BP, day 20 of gestation: 151.38±5.65 mmHg VDd vs. 152.00±4.10 mmHg VDh), or proteinuria. Fetal anthropometrics were similar between the groups, whereas VDd displayed lower placental:fetal weight ratios (0.15 vs. 0.16 g/g, p=0.01) and increased sFlt-1/PlGF ratio. Expression of hREN was lower in placenta of VDd dams (0.82±0.44 AU vs. 1.52±0.15 AU, p=0.04). Expression of key vitamin D metabolizing enzymes was unchanged. Conclusion Dietary vitamin D intervention did not alter key aspects of the preeclampsia phenotype using the transgenic rodent model of human RAS-mediated pre-eclampsia, plausibly due to altered vitamin D metabolism or excretion in the transgenic rats.


      PubDate: 2016-06-16T18:07:20Z
       
  • Gender, Race, Age, and Regional Differences in the Association of Pulse
           Pressure with Atrial Fibrillation: The Reasons for Geographic and Racial
           Differences in Stroke Study
    • Abstract: Publication date: Available online 7 June 2016
      Source:Journal of the American Society of Hypertension
      Author(s): Lama Ghazi, Monika M. Safford, Yulia Khodneva, Wesley T. O’Neal, Elsayed Z. Soliman, Stephen P. Glasser
      Background Pulse pressure (PP) has been associated with atrial fibrillation (AF) independent of other measures of arterial pressure, and other AF risk factors. However, the impact of gender, race, age, and geographic region on the association between PP and AF is unclear. Method A cross-sectional study of data from 25,109 participants (65±9 years of age), 54% women, 40% black) from the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study recruited between 2003 and 2007 were analyzed. AF was defined as a self-reported history of a previous physician diagnosis, or presence of AF on ECG. Multivariable logistic regression models were used to calculate the odds ratio for AF. Interactions for age (< and >75 years), gender, race, and region were examined in the multivariable adjusted model. Results The prevalence of AF increased with widening PP (7.9%, 7.9%, 8.4%, and 11.6%, for PP <45, 45-54.9, 55-64.9, and >65 mm Hg, respectively, [p for trend <0.001]), but attenuated with adjustment. No differences by gender, race, and region were observed. However, there was evidence of significant effect modification by age (interaction p=0.0002). For those <75 years of age, PP >65 mm Hg compared to PP<45 mm Hg was significantly associated with higher risk of AF in both the unadjusted and multivariable adjusted models (Odds Ratio 1.66 [95% CI 1.42-1.94] and 1.32 [95% CI 1.03-1.70], respectively). In contrast, higher PP (55-64.9 mm Hg) among those >75 years of age was significantly associated with a lower risk of AF. Conclusion The relationship between PP and AF may differ for older vs. younger individuals.


      PubDate: 2016-06-16T18:07:20Z
       
  • A reappraisal of clinical research on arterial stiffness in hypertension
           in France
    • Abstract: Publication date: Available online 14 May 2016
      Source:Journal of the American Society of Hypertension
      Author(s): Michel E. Safar



      PubDate: 2016-05-19T13:22:02Z
       
  • Impaired metabolic profileis a predictor of capillary rarefaction in a
           population of hypertensive and normotensive individuals
    • Abstract: Publication date: Available online 13 May 2016
      Source:Journal of the American Society of Hypertension
      Author(s): Areti Triantafyllou, Panagiota Anyfanti, Georgios Triantafyllou, Xenophon Zabulis, Spyros Aslanidis, Stella Douma
      Capillary rarefaction is typically encountered in essential hypertension, yet identification of factors interfering with this phenomenon remains substantially underinvestigated. We examined whether components of metabolic profile (dyslipidemia, insulin resistance), inflammatory (high sensitivity C-reactive protein, hsCRP) and angiogenic (vascular endothelial growth factor, VEGF) factors are implicated in this phenomenon in a population of newly-diagnosed, never-treated hypertensive patients and normotensive controls. Nailfold capillary density was estimated with nail fold capillaroscopy using specifically designed software. A total of 159individuals, 93 hypertensives and 66 normotensives, were included. Nailfold capillary density was lower among hypertensives compared to normotensives (146.4±31.0 vs 155.4±26.9 respectively, p=0.047). In the total population, capillary density significantly correlated with HDL (r=0.232, p=0.003), HDL/LDL ratio (r=0.175, p=0.025), age (r=0.236, p=0.003), but neither with VEGF or hsCRP. An inverse association was found with body mass index (r=–0.174, p=0.029), insulin levels (r=–0.200, p=0.018) and HOMA-IR (r=–0.223, p=0.009). In the separate analysis for the hypertensive population, sex (p=0.014) and HOMA-IR (p=0.011) were identified as significant predictors of capillary rarefaction after adjustment for other factors. On the contrary, only HDL levels (p=0.036) predicted capillary density in the multiple regression model for the normotensive population. Different aspects of impaired metabolic profile, i.e. insulin resistance and low HDL levels, but not angiogenic or inflammatory markers, appear to be independently associated with capillary rarefaction in hypertensive and normotensive individuals.


      PubDate: 2016-05-14T07:23:36Z
       
  • Exercise Systolic Blood Pressure Variability is Associated with Increased
           Risk for New-Onset Hypertension among Normotensive Adults
    • Abstract: Publication date: Available online 13 April 2016
      Source:Journal of the American Society of Hypertension
      Author(s): Assaf Berger, Ehud Grossman, Moshe Katz, Shaye Kivity, Robert Klempfner, Shlomo Segev, Ilan Goldenberg, Yehezkel Sidi, Elad Maor
      Objective Both resting blood pressure (BP) variability and exercise BP previously showed association with incident hypertension. The aim of the present study was to examine whether visit-to-visit variability in exercise systolic blood pressure (SBP) can predict the risk for new onset hypertension among normotensive adults. Methods We investigated 6,546 normotensive men and women who were annually screened in a tertiary medical center and completed treadmill exercise tests at each visit. Based on the initial three baseline annual visits, long term inter-visit variability of exercise SBP among the three tests was measured using standard deviation (SD) and coefficient of variation (CV) for each participant. The rate of newly diagnosed hypertension was measured in different variability levels during 6±3 years of follow-up. Results Multivariate analysis adjusted for various clinical factors, including resting BP, showed that each 5 mmHg rise in the SD of exercise SBP resulted in a significant 5% increase in the risk for the development of future hypertension (p=0.015). Subjects in the upper exercise SBP SD variability tertile had a 28% (p=0.007) increased risk for hypertension during follow-up, as compared with those in the lowest tertile. Similar results were achieved for the assessment of CV of exercise SBP. Conclusions Visit-to-visit variability in exercise SBP can predict the development of future hypertension among normotensive individuals.


      PubDate: 2016-05-14T07:23:36Z
       
  • Intrafamilial aggregation and heritability of tissue Doppler indexes of
           left ventricular diastolic function in a group of African descent
    • Abstract: Publication date: Available online 13 April 2016
      Source:Journal of the American Society of Hypertension
      Author(s): Vernice R. Peterson, Gavin R. Norton, Carlos D. Libhaber, Muzi J. Maseko, Pinhas Sareli, Angela J. Woodiwiss
      Although several indexes of left ventricular (LV) diastolic function show heritability, the genetic influence on the tissue Doppler index, E/eʹ (early transmitral velocity/velocity of myocardial tissue lengthening), an index of LV filling pressures in those of black African descent is currently unknown. Furthermore, whether any genetic influences on E/eʹ are through an impact of LV remodeling or aortic function is unknown. Intrafamilial aggregation and heritability (SAGE software) of E/eʹ (echocardiography) were assessed in 129 nuclear families (29 spouse pairs, 216 parent–child pairs, and 113 sibling–sibling pairs) from an urban developing community of black Africans, independent of LV mass index (LVMI), LV relative wall thickness (RWT), central aortic systolic pressure (SBPc), and backward wave pressures (Pb) (applanation tonometry, SphygmoCor software). Independent of confounders including LVMI and RWT, E/eʹ was correlated in parent–child (r = 0.23; P < .001) and sibling–sibling (r = 0.29; P < .005), but not in spouse (r = 0.13; P = .51) pairs. The relationships between parent–child (r = 0.22; P < .001) and sibling–sibling (r = 0.29; P < .005) pairs persisted with adjustments for SBPc. The relationships between parent–child (r = 0.22; P < .001) and sibling–sibling (r = 0.26; P < .01) pairs also persisted with adjustments for Pb. Independent of confounders including LVMI and RWT, E/eʹ showed significant heritability (h2 ± standard error of the mean [SEM] = 0.51 ± 0.11; P < .0001) which similarly persisted with adjustments for SBPc (h2 ± SEM = 0.50 ± 0.11; P < .0001) and Pb (h2 ± SEM = 0.49 ± 0.11; P < .0001). In conclusion, in a group of African ancestry, independent of LV remodeling and aortic function, E/eʹ shows significant intrafamilial aggregation and robust heritability. Hence, genetic factors may play an important role in determining moderate-to-severe LV diastolic dysfunction independent of cardiac remodeling or aortic function in groups of black African ancestry.


      PubDate: 2016-05-14T07:23:36Z
       
  • We are what we eat (and drink)
    • Abstract: Publication date: Available online 11 April 2016
      Source:Journal of the American Society of Hypertension
      Author(s): Norman M. Kaplan



      PubDate: 2016-05-14T07:23:36Z
       
  • Baroreflex Activation Therapy: Future use as therapy for severe or
           resistant hypertension?
    • Abstract: Publication date: Available online 30 April 2016
      Source:Journal of the American Society of Hypertension
      Author(s): John D. Bisognano



      PubDate: 2016-05-14T07:23:36Z
       
  • HOPE-3 and SPRINT: Two Landmark Trials with Different Outcomes?
    • Abstract: Publication date: Available online 29 April 2016
      Source:Journal of the American Society of Hypertension
      Author(s): John B. Kostis, Suzanne Oparil



      PubDate: 2016-05-14T07:23:36Z
       
  • From the Editor
    • Abstract: Publication date: Available online 25 April 2016
      Source:Journal of the American Society of Hypertension
      Author(s): Daniel Levy



      PubDate: 2016-05-14T07:23:36Z
       
  • Editorial Board
    • Abstract: Publication date: May 2016
      Source:Journal of the American Society of Hypertension, Volume 10, Issue 5




      PubDate: 2016-05-14T07:23:36Z
       
  • Table of Contents
    • Abstract: Publication date: May 2016
      Source:Journal of the American Society of Hypertension, Volume 10, Issue 5




      PubDate: 2016-05-14T07:23:36Z
       
  • Does this patient have hypertensive encephalopathy?
    • Abstract: Publication date: May 2016
      Source:Journal of the American Society of Hypertension, Volume 10, Issue 5
      Author(s): Foteini Christopoulou, Evangelos C. Rizos, Paraskevi Kosta, Maria I. Argyropoulou, Moses Elisaf
      A 63-year-old man was admitted to our hospital for further investigation and management of brain metastases. The patient was initially presented with a 4-day history of confusion. On the day of admission, the patient was confused, agitated, disorientated in place and time, and had visual disturbances. His blood pressure was repeatedly recorded high, with levels of systolic blood pressure between 170–210 mm Hg. A brain magnetic resonance imaging showed areas of high signal on T2 and fluid-attenuated inversion recovery images, located bilaterally in the white matter of the occipital regions and unilateral in the left frontal lobe, suggestive of posterior reversible encephalopathy syndrome. Aggressive treatment of hypertension resulted in complete resolution of the clinical and radiologic features of the syndrome.


      PubDate: 2016-05-14T07:23:36Z
       
  • Salt-induced hypertension—what do we really know about the
           mechanism?
    • Abstract: Publication date: Available online 12 May 2016
      Source:Journal of the American Society of Hypertension
      Author(s): Michael J. Bloch



      PubDate: 2016-05-14T07:23:36Z
       
  • Are we in the midst of a transition in cardiovascular epidemiology?
    • Abstract: Publication date: Available online 4 May 2016
      Source:Journal of the American Society of Hypertension
      Author(s): Michael J. Bloch



      PubDate: 2016-05-14T07:23:36Z
       
  • Allopurinol: can it undo the harm done by high dietary fructose?
    • Abstract: Publication date: Available online 11 April 2016
      Source:Journal of the American Society of Hypertension
      Author(s): Barry J. Materson



      PubDate: 2016-05-14T07:23:36Z
       
  • Rescue baroreflex activation therapy after Stanford B aortic dissection
           due to therapy-refractory hypertension
    • Abstract: Publication date: Available online 12 April 2016
      Source:Journal of the American Society of Hypertension
      Author(s): Kay F. Weipert, Astrid Most, Oliver Dörr, Inga Helmig, Meshal Elzien, Gabriele Krombach, Christian W. Hamm, Damir Erkapic, Joern Schmitt
      Clinical trials have demonstrated significant and durable reduction in arterial pressure from baroreflex activation therapy (BAT) in patients with resistant arterial hypertension. There is a lack of data, however, concerning the use of BAT in a rescue approach during therapy-refractory hypertensive crisis resulting in life-threatening end-organ damage. Here, we describe the first case in which BAT was applied as a rescue procedure in an intensive care setting after ineffective maximum medical treatment. A 34-year-old male patient presented with Stanford B aortic dissection and hypertensive crisis. The dissection membrane extended from the left subclavian artery down to the right common iliac artery, resulting in a total arterial occlusion of the right leg. After emergency thoracic endovascular aortic repair and femorofemoral crossover bypass, the patient developed a compartment syndrome of the right lower limb, ultimately leading to amputation of the right leg above the knee. Even under deep sedation recurrent hypertensive crises of up to 220 mm Hg occurred that could not be controlled by eight antihypertensive drugs of different classes. Screening for secondary hypertension was negative. Eventually, rescue implantation of right-sided BAT was performed as a bailout procedure, followed by immediate activation of the device. After a hospital stay of a total of 8 weeks, the patient was discharged 2 weeks after BAT initiation with satisfactory blood pressure levels. After 1-year follow-up, the patient has not had a hypertensive crisis since the onset of BAT and is currently on fourfold oral antihypertensive therapy. The previously described bailout procedures for the treatment of life-threatening hypertensive conditions that are refractory to drug treatment have mainly comprised the interventional denervation of renal arteries. The utilization of BAT is new in this emergency context and showed a significant, immediate, and sustained reduction of blood pressure levels after activation. To our knowledge, we report the first case of an immediate activation of a barostim while the device is usually not activated before 2 to 4 weeks after implantation to allow time for the surgical site to heal. During the follow-up period, the healing process was not impaired, and a significant, immediate, and sustained reduction of blood pressure levels after activation could be observed. This treatment option offers maximum adherence to antihypertensive therapy to avoid future cardiovascular end-organ damage and possibly reduce antihypertensive medication and undesirable side effects.


      PubDate: 2016-05-14T07:23:36Z
       
  • Association between uric acid and renal function in hypertensive patients:
           which role for systemic vascular involvement?
    • Abstract: Publication date: Available online 12 May 2016
      Source:Journal of the American Society of Hypertension
      Author(s): Giulio Geraci, Giuseppe Mulè, Massimiliano Morreale, Claudia Cusumano, Antonella Castiglia, Francesca Gervasi, Francesco D’Ignoto, Manuela Mogavero, Calogero Geraci, Santina Cottone
      The role of systemic vascular involvement in mediating the association between serum uric acid (SUA) and renal function in hypertension has not been explored. Main purpose of our study was to investigate whether morphofunctional vascular changes, assessed as carotid intima-media thickness (cIMT) and aortic pulse wave velocity (aPWV), might mediate the association between SUA and renal damage. We enrolled 523 hypertensive subjects with or without CKD and divided population into tertiles of SUA based on sex-specific cut-off values. cIMT and aPWV were higher in uppermost SUA-tertile patients when compared to those in the lowest ones (all p<0.001). Uricemia strongly correlated with cIMT and aPWV at univariate analysis (p<0.001), and with cIMT after adjustment for confounders (p<0.001). Adjustment for cIMT attenuated the relationship between SUA and eGFR (p=0.019). Systemic vascular changes seem partially to mediate the association between SUA and renal function in hypertensive patients, regardless of kidney function.


      PubDate: 2016-05-14T07:23:36Z
       
  • SPRINT. Counteracting the risk of prehypertension?
    • Abstract: Publication date: Available online 13 May 2016
      Source:Journal of the American Society of Hypertension
      Author(s): Luis M. Ruilope



      PubDate: 2016-05-14T07:23:36Z
       
  • Water aerobics is followed by short-time and immediate systolic blood
           pressure reduction in overweight and obese hypertensive women
    • Abstract: Publication date: Available online 12 May 2016
      Source:Journal of the American Society of Hypertension
      Author(s): Raphael Martins Cunha, Gisela Arsa, Eduardo Borba Neves, Lorena Curado Lopes, Fabio Santana, Marcelo Vasconcelos Noleto, Thais I. Rolim, Alexandre Machado Lehnen
      One exercise training session such as walking, running and resistance can lead to a decrease in blood pressure in normotensive and hypertensive individuals, but few studies have investigated the effects of exercise training in an aquatic environment for overweight and obese hypertensive individuals. We aimed to assess the acute effects of a water aerobics session on blood pressure (BP) changes in pharmacologically treated overweight and obese hypertensive women. A randomized crossover study was carried out with 18 hypertensive women, 10 of them were overweight (54.4±7.9 years; BMI: 27.8±1.7 kg/m2) and eight obese (56.4±6.6 years; BMI: 33.0±2.0 kg/m2). The water aerobics exercise session consisted of a 45-minute training at the intensity of 70-75% of maximum heart rate adjusted for the aquatic environment. The control group did not enter the pool and did not perform any exercise. We measured systolic (SBP) and diastolic blood pressure (DBP) before, immediately after and every 10 minutes up to 30 minutes after the aerobic exercise or control session. Overall (n=18), DBP did not change after the water aerobic exercise and control session, and SBP decreased at 10 and 20 minutes post-exercise compared to the control session. Among overweight women, SBP decreased at 10 and 20 minutes post-exercise. In contrast, among obese women, SBP decreased only at 10 minutes post-exercise. SBP variation was –2.68 mm Hg in overweight and –1.24 mm Hg in obese women. In conclusion, the water aerobics session leads to a reduction in SBP, but not in DBP, during 10 and 20 minutes post-exercise recovery. Thus, it may be safely prescribed to overweight and obese women.


      PubDate: 2016-05-14T07:23:36Z
       
  • Severe and Refractory Hypertension in a Young Woman
    • Abstract: Publication date: Available online 4 April 2016
      Source:Journal of the American Society of Hypertension
      Author(s): René H. Cuadra, William B. White
      Background Refractory hypertension in a young person is an uncommon clinical problem, but one that may be referred to hypertension specialists. Factitious hypertension is fortunately quite rare, but should be considered when evaluating patients who are refractory to numerous classes of antihypertensive therapies and have failed to achieve control despite input from multiple providers. Report of a Case A 19 year old woman was referred to us after failing to achieve blood pressure control by a primary physician and 2 subspecialists in nephrology and hypertension; she also had numerous emergency department visits for symptomatic and severe hypertension. Exhaustive diagnostic testing for secondary causes and witnessed medication dosing in an outpatient setting was unrevealing. Subsequent inpatient admission demonstrated normalization of BPs with small doses of intravenous antihypertensive agents. During the hospitalization, she was observed “pocketing” her oral medications in the buccal folds, and then discarding them in a trash container. Confrontation by psychiatrists and the hypertension specialists led to the admission that she had learned to start and stop beta-blockers and clonidine to induce severe, rebound hypertension. Discussion Factitious and induced hypertension is a rare cause of resistant or refractory hypertension. Nevertheless, hypertension specialists should suspect the diagnosis when there is a history of visits to multiple institutions and physicians, negative secondary workup, absence of overt target organ damage, history of psychiatric illness, and employment in the medical field.


      PubDate: 2016-04-07T19:51:21Z
       
  • A practical approach for measurement of antihypertensive medication
           adherence in patients with resistant hypertension
    • Abstract: Publication date: Available online 5 April 2016
      Source:Journal of the American Society of Hypertension
      Author(s): Nathalia Batista Correa, Ana Paula de Faria, Alessandra M.V. Ritter, Andrea Rodrigues Sabbatini, Aurélio Almeida, Veridiana Brunelli, David A. Calhoun, Heitor Moreno, Rodrigo Modolo
      Background Confirmation of medication adherence is a challenge in clinical practice and essential for the accurate diagnosis of resistant hypertension. Although it is well established that drug adherence is critical for controlling BP, there are still difficulties applying a simple, inexpensive, and reliable assessment of adherence in the clinical setting. We aimed to test a simple method to assess adherence in RH patients. Methods A pilot study with normotensives or mild/moderate hypertensive subjects was performed in order to provide a fluorescence cutoff point for adherence. After that, twenty-one patients referred to the Resistant Hypertension Clinic had triamterene prescribed and were monitored for a 30-day period. We conducted two unannounced randomly selected home visits for urine collection to test drug intake that day. Office, home and 24-hour ambulatory blood pressure, biochemical data, and Morisky Monitoring Adherence Scale (MMAS-8) were systematically acquired. According to adherence indicated by urine fluorescence, subjects were divided into adherent and non-adherent groups. Results We found 57% of non-adherence. No differences were found between groups regarding baseline characteristics or prescribed medications; Kappa’s test showed concordance between adherence through MMAS-8 and fluorescence (Kappa=0.61; CI95% 0.28-0.94; p=0.005). Non-adherent patients had higher office (81±11 vs 73±6 mmHg, p=0.03), 24-h ABPM (75±9 vs 66±7 mmHg, p=0.01) and HBPM (77±9 vs 67±8 mmHg, p=0.01) diastolic BP than their counterparts. Conclusions Non-adherence to antihypertensive therapy is high in patients with RH, even when assessed in clinics specialized in this condition. Fluorometry to detect a drug in the urine of RH patients is safe, easy and reliable method to assess adherence.


      PubDate: 2016-04-07T19:51:21Z
       
  • From the Editor
    • Abstract: Publication date: Available online 29 March 2016
      Source:Journal of the American Society of Hypertension
      Author(s): Daniel Levy



      PubDate: 2016-04-02T18:51:09Z
       
  • ‘Translational’ Medicine: Transforming SPRINT findings into
           clinical practice
    • Abstract: Publication date: Available online 31 March 2016
      Source:Journal of the American Society of Hypertension
      Author(s): Dominic A. Sica, Robert A. Phillips, William B. White, John D. Bisognano, Raymond R. Townsend



      PubDate: 2016-04-02T18:51:09Z
       
  • Remarks from the new President of the American Society of Hypertension
    • Abstract: Publication date: Available online 24 March 2016
      Source:Journal of the American Society of Hypertension
      Author(s): John D. Bisognano



      PubDate: 2016-03-28T17:16:39Z
       
  • Future Prospects for Renal Artery Denervation
    • Abstract: Publication date: Available online 26 March 2016
      Source:Journal of the American Society of Hypertension
      Author(s): Deepak L. Bhatt



      PubDate: 2016-03-28T17:16:39Z
       
  • Hypertensive Encephalopathy: What’s in a Name?
    • Abstract: Publication date: Available online 26 March 2016
      Source:Journal of the American Society of Hypertension
      Author(s): Phyllis August



      PubDate: 2016-03-28T17:16:39Z
       
  • The future for renal denervation depends on embracing the lessons learned
           from our previous studies
    • Abstract: Publication date: Available online 23 March 2016
      Source:Journal of the American Society of Hypertension
      Author(s): Murray Epstein
      •The knowledge base for the continued development of catheter-based renal denervation (RDN) is robust •A critical determinant of RDN success is the delivery of sufficient radiofrequency energy to both proximal and distal renal nerves, including in the renal artery divisions •New multi–electrode catheters circumvent the several drawbacks of early models.


      PubDate: 2016-03-23T16:14:14Z
       
  • Renal denervation for human hypertension: is there a future?
    • Abstract: Publication date: Available online 8 March 2016
      Source:Journal of the American Society of Hypertension
      Author(s): Joseph L. Izzo, Sheldon W. Tobe
      The sympathetic nervous system (SNS) plays a permissive, if not primary causal, role in the genesis and maintenance of human essential hypertension. Excessive SNS activity in man is most apparent in early forms of hypertension (prehypertension and white-coat-type). Renal nerves are of particular interest because of their roles in modulating the activity of the renin-angiotensin system and renal sodium excretion. Renal denervation substantially ameliorates the development of hypertension in animal models such as renovascular, spontaneously hypertensive, and steroid-induced hypertension in rats and aortic coarctation in dogs. In man, catheter ablation of renal nerves has been undertaken in the late phases of hypertension; in a rigorously controlled trial in resistant hypertension (SYMPLICITY HTN-3), renal denervation did not reduce blood pressure over the long term. Is this because renal denervation is more appropriate to prevent than treat late-stage hypertension? Are there anatomical or technical barriers yet to be overcome in the procedure? These and other issues are addressed by two experts in this issue of the Controversies series: Deepak L. Bhatt and Murray Epstein.


      PubDate: 2016-03-09T03:56:18Z
       
  • Association of dental infections with systemic diseases in Brazilian
           Native Indigenous: A cross-sectional study
    • Abstract: Publication date: Available online 2 March 2016
      Source:Journal of the American Society of Hypertension
      Author(s): L.S.F. Ribeiro, J.N. Santos, C.L.Z. Vieira, B. Caramelli, L.M.P. Ramalho, P.R. Cury
      The aim of this cross-sectional study was to evaluate the association between dental infections and systemic diseases in the Indigenous population of Brazil. A representative sample of 225 Indigenous (≥19 years) was assessed. The T-test and bivariate and logistic models were used to assess the associations of diabetes, hypertension, and obesity with dental caries and destructive periodontal disease. After adjustments for covariates, dental caries was associated with hypertension (OR=1.95, 95% CI=1.03-3.66, p=0.04). Individuals with destructive periodontal disease had a higher systolic blood pressure (124 ± 20.34 mmHg) than those without destructive periodontal disease (117.52 ± 16.54 mmHg, p=0.01). In conclusion, dental infections were found to be associated with hypertension in the present population. Thus, patients diagnosed with hypertension should be referred for dental evaluation and vice-versa.


      PubDate: 2016-03-09T03:56:18Z
       
  • Utility of Ambulatory Blood Pressure Monitoring (ABPM) in the Evaluation
           of Elevated Clinic Blood Pressures (BPs) in Children
    • Abstract: Publication date: Available online 3 March 2016
      Source:Journal of the American Society of Hypertension
      Author(s): Susan M. Halbach, Robin Hamman, Karyn Yonekawa, Coral Hanevold
      Although ABPM is recognized for its role in assessing white coat hypertension (WCH), other uses include evaluation of treatment adequacy, nocturnal hypertension, dipping status, and hypertension severity. We performed a retrospective study of ABPMs completed at a single center from November 2007 to October 2011 to determine the frequency of WCH, prehypertension, and hypertension in children and the correlation of these findings with office BPs. 247 ABPMs were performed in 206 children, ages 4-20 years, including 48 recordings in 39 diabetic patients and 64 recordings in treated hypertensive patients. We found a poor correlation between hypertensive status based on clinic BP (cBP) and diagnosis on ABPM, and evidence for a white-coat effect (WCE). Among treated patients, ABPM results resulted in medication changes in 63%. We conclude that ABPM is a useful tool for characterizing hypertensive status and treatment adequacy in children.


      PubDate: 2016-03-09T03:56:18Z
       
  • Long sleep duration: A non-conventional indicator of arterial stiffness in
           Japanese at high risk of cardiovascular disease: the J-HOP Study
    • Abstract: Publication date: Available online 3 March 2016
      Source:Journal of the American Society of Hypertension
      Author(s): Satoshi Niijima, Michiaki Nagai, Satoshi Hoshide, Mami Takahashi, Masahisa Shimpo, Kazuomi Kario
      Background Long and short sleep durations were reported as independently associated with hypertension, aortic stiffness and cardiovascular disease. High-sensitivity C-reactive protein (hs-CRP) was shown to be associated with increased aortic stiffness. Here we investigated the relationship between self-reported sleep duration and pulse wave velocity (PWV) in the elderly at high risk of cardiovascular disease. We also investigated whether hs-CRP moderates this relationship. Methods Among 4,310 patients with > 1 cardiovascular risks recruited for the Japan Morning Surge-Home Blood Pressure (J-HOP) Study, a questionnaire including items on daily sleep duration was completed. We measured the brachial-ankle PWV (baPWV) and hs-CRP levels in 2,304 of these patients (mean age 64.7 years, 49.6% males). Results In accord with the patients’ sleep duration (<6 h, ≥6 to <8 h, and ≥8 h per night), significant associations between sleep duration and the PWV were observed (1594 vs. 1644 vs. 1763 cm/s, p<0.0001). In the multiple regression analysis adjusted for age, body mass index, total cholesterol, HbA1c and clinic systolic blood pressure (SBP), long sleep duration (≥8 h per night) (p<0.05) and log hs-CRP (p<0.05) were significantly positively associated with PWV when the patients with 6–8-h sleep duration were defined as a reference group. Significant interactions of long sleep duration by age and that by antihypertensive medication for baPWV were observed. The effect of long sleep on PWV was greatest in the oldest age group. Conclusions Long sleep duration and hs-CRP were significant indicators of increased baPWV in this elderly high-risk Japanese population. Age and antihypertensive medication use were significant modulators of the relationship between long sleep duration and arterial stiffness.


      PubDate: 2016-03-09T03:56:18Z
       
  • Ambulatory blood pressure reduction following high-intensity interval
           exercise performed in water or dryland condition
    • Abstract: Publication date: Available online 3 March 2016
      Source:Journal of the American Society of Hypertension
      Author(s): Philippe Sosner, Mathieu Gayda, Olivier Dupuy, Mauricio Garzon, Christopher Lemasson, Vincent Gremeaux, Julie Lalongé, Mariel Gonzales, Douglas Hayami, Martin Juneau, Anil Nigam, Laurent Bosquet
      We aimed to compare blood pressure (BP) responses following moderate-intensity continuous exercise (MICE), high-intensity interval exercise (HIIE) in dry land or HIIE in immersed condition, using 24-h ambulatory blood pressure monitoring. Forty-two individuals (65±7 years, 52% men) with a baseline BP ≥130/85 mm Hg (systolic/diastolic, SBP/DBP), were randomly assigned to perform one of the three following exercises on a stationary cycle: MICE (24-min at 50% peak power output (PPO)) or HIIE in dry land (two sets of 10-min with phases of 15-sec 100% PPO interspersed by 15-sec of passive recovery) or HIIE in up-to-the-chest immersed condition. While MICE modified none of the 24-h average hemodynamic variables, dryland HIIE induced a 24-h BP decrease (SBP: -3.6±5.7 / DBP: -2.8±3.0 mm Hg, P<.05) and, to a much greater extent, immersed HIIE (SBP: -6.8±9.5 / DBP: -3.0±4.5 mm Hg, P<.05). The one condition that modified 24-h PWV was immersed HIIE (-0.21±0.30 m/s, P<.05).


      PubDate: 2016-03-09T03:56:18Z
       
  • Angioedema With Renin Angiotensin System Drugs and Neutral Endopeptidase
           Inhibitors
    • Abstract: Publication date: Available online 8 March 2016
      Source:Journal of the American Society of Hypertension
      Author(s): John B. Kostis, Abel E. Moreyra, William J. Kostis



      PubDate: 2016-03-09T03:56:18Z
       
 
 
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