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  Subjects -> HISTORY (Total: 1387 journals)
    - HISTORY (853 journals)
    - History (General) (55 journals)
    - HISTORY OF AFRICA (52 journals)
    - HISTORY OF ASIA (57 journals)
    - HISTORY OF AUSTRALASIA AREAS (9 journals)
    - HISTORY OF EUROPE (187 journals)
    - HISTORY OF THE AMERICAS (141 journals)
    - HISTORY OF THE NEAR EAST (33 journals)

HISTORY (853 journals)            First | 1 2 3 4 5     

Showing 601 - 452 of 452 Journals sorted alphabetically
Pacific Historical Review     Full-text available via subscription   (Followers: 6)
Pacific Journal of Baptist Research     Open Access  
Paedagogica Historica: International Journal of the History of Education     Hybrid Journal   (Followers: 4)
Palestine Exploration Quarterly     Hybrid Journal   (Followers: 10)
Pallas : Revue d'études antiques     Open Access   (Followers: 2)
Paradigmi     Full-text available via subscription  
Parergon     Full-text available via subscription   (Followers: 1)
Parliamentary History     Hybrid Journal   (Followers: 7)
Parliaments, Estates and Representation     Hybrid Journal   (Followers: 3)
Pasado Abierto     Open Access  
Passato e presente     Full-text available via subscription   (Followers: 1)
Past & Present     Hybrid Journal   (Followers: 161)
Pastoralism : Research, Policy and Practice     Open Access   (Followers: 4)
Pecia     Full-text available via subscription  
Penn History Review     Open Access   (Followers: 1)
Pennsylvania History: A Journal of Mid-Atlantic Studies     Full-text available via subscription   (Followers: 3)
Peritia     Full-text available via subscription   (Followers: 7)
Perspective     Open Access  
Pharmaceutical Historian     Open Access  
Philippine Studies     Full-text available via subscription   (Followers: 2)
Pilipinas: A Journal of Philippine Studies     Full-text available via subscription   (Followers: 1)
Pleine Marge     Full-text available via subscription   (Followers: 1)
PLURA, Revista de Estudos de Religião / PLURA, Journal for the Study of Religion     Open Access   (Followers: 3)
Policy and Society     Hybrid Journal   (Followers: 6)
Polis : The Journal of the Society for Greek Political Thought     Hybrid Journal   (Followers: 7)
Politics & Society     Hybrid Journal   (Followers: 31)
Politikon: South African Journal of Political Studies     Hybrid Journal   (Followers: 3)
Politique et Sociétés     Full-text available via subscription   (Followers: 1)
Popular Music History     Hybrid Journal   (Followers: 13)
Postcolonial Directions in Education     Open Access   (Followers: 1)
Postcolonial Studies     Hybrid Journal   (Followers: 19)
Postcolonial Text     Open Access   (Followers: 9)
Préhistoires méditerranéennes     Open Access   (Followers: 2)
Proceedings of the Aristotelian Society (hardback)     Hybrid Journal   (Followers: 4)
Proceedings of the Institution of Civil Engineers - Engineering History and Heritage     Hybrid Journal   (Followers: 2)
Proceedings of the Linnean Society of New South Wales     Full-text available via subscription   (Followers: 2)
Proceedings of the Prehistoric Society     Hybrid Journal   (Followers: 8)
Proceedings of the Royal Society of Queensland, The     Full-text available via subscription  
Proceedings of the Zoological Society     Hybrid Journal   (Followers: 1)
Procesos Historicos     Open Access  
Prose Studies: History, Theory, Criticism     Hybrid Journal   (Followers: 2)
Psychoanalysis and History     Hybrid Journal   (Followers: 3)
Psychoanalysis Culture & Society     Hybrid Journal   (Followers: 8)
Publications du Centre Européen d'Etudes Bourguignonnes     Full-text available via subscription  
Purdue Historian     Open Access  
Quaderns d’Història de l’Enginyeria     Open Access  
Quaker History     Full-text available via subscription   (Followers: 5)
Queensland Naturalist     Full-text available via subscription  
Queensland Review     Full-text available via subscription  
Questes : Revue pluridisciplinaire d'études médiévales     Open Access  
Quintana. Revista de Estudos do Departamento de Historia da Arte     Open Access  
Radical History Review     Full-text available via subscription   (Followers: 23)
Rasenna : Journal of the Center for Etruscan Studies     Open Access   (Followers: 2)
Rationality and Society     Hybrid Journal   (Followers: 6)
Raven : A Journal of Vexillology     Hybrid Journal  
Reinardus     Hybrid Journal  
Relaciones. Estudios de historia y sociedad     Open Access  
Renaissance Drama     Full-text available via subscription   (Followers: 10)
Renaissance Quarterly     Full-text available via subscription   (Followers: 41)
Renaissance Studies     Hybrid Journal   (Followers: 20)
Res Historica     Open Access  
Rethinking History: The Journal of Theory and Practice     Hybrid Journal   (Followers: 25)
Reti Medievali Rivista     Open Access  
Review of Central and East European Law     Hybrid Journal   (Followers: 8)
Reviews in American History     Full-text available via subscription   (Followers: 20)
Revista Alétheia     Open Access  
Revista Análisis Internacional     Open Access  
Revista Brasileira de Historia     Open Access   (Followers: 1)
Revista Brasileira de História das Religiões     Open Access  
Revista Chilena de Historia del Derecho     Open Access   (Followers: 1)
Revista Crítica Histórica     Open Access  
Revista de Divulgação Interdisciplinar     Open Access  
Revista de Estudios Historico-Juridicos     Open Access   (Followers: 1)
Revista de História     Open Access  
Revista de História Bilros. História(s), Sociedade(s) e Cultura(s)     Open Access   (Followers: 1)
Revista de História da UEG     Open Access  
Revista de Historia Social y de las Mentalidades     Open Access  
Revista do Instituto Histórico e Geográfico do Rio Grande do Sul     Open Access  
Revista Historia Autónoma     Open Access  
Revista História da Educação - History of Education Journal     Open Access  
Revista Maracanan     Open Access  
Revista Memória em Rede     Open Access  
Revista Mosaico     Open Access  
Revista Paginas     Open Access   (Followers: 1)
Revolutionary Russia     Hybrid Journal   (Followers: 7)
Revue archéologique de l'Est     Open Access   (Followers: 3)
Revue archéologique du Centre de la France     Open Access   (Followers: 1)
Revue d'histoire de l'Amérique française     Full-text available via subscription   (Followers: 1)
Revue d'Histoire de l'Eglise de France     Full-text available via subscription   (Followers: 1)
Revue d'histoire de l'enfance     Open Access  
Revue d'Histoire des Textes     Full-text available via subscription  
Revue d'histoire du XIXe siècle     Open Access   (Followers: 4)
Revue d'Histoire Ecclésiastique     Full-text available via subscription   (Followers: 1)
Revue de l’Histoire des Religions     Open Access   (Followers: 7)
Revue des Études Arméniennes     Full-text available via subscription   (Followers: 1)
Revue d’études comparatives Est-Ouest (RECEO)     Open Access  
Revue historique des armées     Open Access   (Followers: 2)
Revue Mabillon     Full-text available via subscription   (Followers: 2)
Rhetoric Society Quarterly     Hybrid Journal   (Followers: 16)
RIHA Journal     Open Access   (Followers: 5)
RIMA: Review of Indonesian and Malaysian Affairs     Full-text available via subscription   (Followers: 1)
Romanticism     Hybrid Journal   (Followers: 5)
Romanticism and Victorianism on the Net     Open Access   (Followers: 5)
Royal Studies Journal     Open Access   (Followers: 1)
Rúbrica Contemporánea     Open Access  
RUDN Journal of Russian History     Open Access  
RUDN Journal of World History     Open Access  
Rural History     Hybrid Journal   (Followers: 14)
Russian Education & Society     Full-text available via subscription   (Followers: 5)
Russian History     Hybrid Journal   (Followers: 11)
Russian Review     Hybrid Journal   (Followers: 15)
Sacris Erudiri     Full-text available via subscription   (Followers: 4)
Saeculum : Jahrbuch für Universalgeschichte     Hybrid Journal   (Followers: 1)
Safundi : The Journal of South African and American Studies     Hybrid Journal   (Followers: 1)
Scandinavian Journal of History     Hybrid Journal   (Followers: 10)
Scando-Slavica     Hybrid Journal   (Followers: 3)
Science & Society     Full-text available via subscription   (Followers: 6)
Science Journal of Volgograd State University. History. Area Studies. International Relations     Open Access  
Scientia Canadensis: Canadian Journal of the History of Science, Technology and Medicine / Scientia Canadensis : revue canadienne d'histoire des sciences, des techniques et de la médecine     Full-text available via subscription   (Followers: 4)
Scientia Militaria : South African Journal of Military Studies     Open Access   (Followers: 4)
Scientiae Studia     Open Access  
Scottish Historical Review     Hybrid Journal   (Followers: 12)
Scrineum Rivista     Open Access  
Scrutiny2: Issues in English Studies in Southern Africa     Hybrid Journal   (Followers: 1)
Senses and Society     Hybrid Journal   (Followers: 7)
Serendipities : Journal for the Sociology and History of the Social Sciences     Open Access  
Sibirica     Full-text available via subscription  
Siècles     Open Access   (Followers: 1)
Signals     Full-text available via subscription   (Followers: 2)
Signos Historicos     Open Access  
Slagmark - Tidsskrift for idéhistorie     Open Access   (Followers: 4)
Slavery & Abolition: A Journal of Slave and Post-Slave Studies     Hybrid Journal   (Followers: 10)
Slavonica     Hybrid Journal   (Followers: 2)
Social History     Hybrid Journal   (Followers: 52)
Social History of Medicine     Hybrid Journal   (Followers: 19)
Social Science History     Full-text available via subscription   (Followers: 14)
Social Sciences and Missions     Hybrid Journal   (Followers: 4)
Società e Storia     Full-text available via subscription   (Followers: 1)
Society     Hybrid Journal   (Followers: 5)
Society and Economy     Full-text available via subscription   (Followers: 3)
SourceOECD National Accounts & Historical Statistics     Full-text available via subscription  
South African Historical Journal     Hybrid Journal   (Followers: 5)
South African Journal of Art History     Full-text available via subscription   (Followers: 2)
South African Journal of Cultural History     Full-text available via subscription   (Followers: 1)
South African Journal of Economic History     Full-text available via subscription   (Followers: 2)
South Asia Research     Hybrid Journal   (Followers: 7)
South Asia: Journal of South Asian Studies     Hybrid Journal   (Followers: 13)
South Asian History and Culture     Hybrid Journal   (Followers: 1)
South Asian Popular Culture     Hybrid Journal   (Followers: 2)
South Asian Survey     Hybrid Journal   (Followers: 4)
South Australian Naturalist, The     Full-text available via subscription  
South Central Review     Full-text available via subscription  
South European Society and Politics     Hybrid Journal   (Followers: 6)
Southeast European and Black Sea Studies     Hybrid Journal   (Followers: 3)
Southwestern Historical Quarterly     Full-text available via subscription   (Followers: 5)
Soviet and Post-Soviet Review     Hybrid Journal   (Followers: 8)
Spontaneous Generations : A Journal for the History and Philosophy of Science     Open Access   (Followers: 2)
Sport in History     Hybrid Journal   (Followers: 9)
Studia Aurea : Revista de Literatura Española y Teoría Literaria del Renacimiento y Siglo de Oro     Open Access   (Followers: 1)
Studia Historiae Ecclesiasticae     Open Access   (Followers: 2)
Studia Historiae Oeconomicae     Open Access  
Studia Iranica     Full-text available via subscription   (Followers: 4)
Studia Litteraria et Historica     Open Access  
Studia z Historii Filozofii     Open Access  
Studies in East European Thought     Hybrid Journal   (Followers: 5)
Studies in Eighteenth Century Culture     Full-text available via subscription   (Followers: 21)
Studies in History     Hybrid Journal   (Followers: 16)
Studies in History and Philosophy of Science Part A     Hybrid Journal   (Followers: 7)
Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences     Hybrid Journal   (Followers: 13)
Studies in People’s History     Hybrid Journal   (Followers: 1)
Studies in the History of Gardens & Designed Landscapes: An International Quarterly     Hybrid Journal   (Followers: 7)
Studies in Western Australian History     Full-text available via subscription   (Followers: 3)
Studium : Tijdschrift voor Wetenschaps- en Universiteits-geschiedenis / Revue d'Histoire des Sciences et des Universités     Open Access   (Followers: 1)
Suomen Sukututkimusseuran Vuosikirja     Open Access  
Sydney Institute Quarterly     Full-text available via subscription  
T'oung Pao     Hybrid Journal   (Followers: 13)
Tangence     Full-text available via subscription  
Tartu Ülikooli ajaloo küsimusi     Open Access  
Tasmanian Historical Studies     Full-text available via subscription  
Teaching History     Full-text available via subscription   (Followers: 6)
Technology and Culture     Full-text available via subscription   (Followers: 22)
temp - tidsskrift for historie     Full-text available via subscription  
Tempo     Open Access   (Followers: 1)
Tempo e Argumento     Open Access  
Temporalidades     Open Access  
The Americas : A Quarterly Review of Latin American History     Full-text available via subscription   (Followers: 5)
The Corvette     Open Access  
The Court Historian : The International Journal of Court Studies     Full-text available via subscription   (Followers: 1)
The Eighteenth Century     Full-text available via subscription   (Followers: 26)
The European Legacy: Toward New Paradigms     Hybrid Journal  
The Hilltop Review : A Journal of Western Michigan University Graduate Student Research     Open Access  
The Historian     Hybrid Journal   (Followers: 32)
The International History Review     Hybrid Journal   (Followers: 21)
The Irish Review     Full-text available via subscription   (Followers: 10)
The Italianist     Hybrid Journal   (Followers: 5)
The Journal of the Historical Society     Hybrid Journal   (Followers: 10)
The Public Historian     Full-text available via subscription   (Followers: 9)
The Seventeenth Century     Hybrid Journal   (Followers: 16)
The Sixties: A Journal of History, Politics and Culture     Hybrid Journal   (Followers: 8)
The South African Journal of Economics     Hybrid Journal   (Followers: 3)

  First | 1 2 3 4 5     

Journal Cover Journal of the American Society of Hypertension
  [SJR: 1.039]   [H-I: 31]   [8 followers]  Follow
    
   Hybrid Journal Hybrid journal (It can contain Open Access articles)
   ISSN (Print) 1933-1711
   Published by Elsevier Homepage  [3175 journals]
  • Is Trump's cardiovascular health “excellent” or are there “serious
           heart concerns”' and comments on the president's blood pressure
    • Authors: Brent M. Egan
      Pages: 148 - 150
      Abstract: Publication date: March 2018
      Source:Journal of the American Society of Hypertension, Volume 12, Issue 3
      Author(s): Brent M. Egan


      PubDate: 2018-04-16T01:54:13Z
      DOI: 10.1016/j.jash.2018.01.010
       
  • Antihypertensive therapy in nondiabetic chronic kidney disease: a review
           and update
    • Authors: Paul J. Der Mesropian; Gulvahid Shaikh; Emmanuelle Cordero Torres; Anum Bilal; Roy O. Mathew
      Pages: 154 - 181
      Abstract: Publication date: March 2018
      Source:Journal of the American Society of Hypertension, Volume 12, Issue 3
      Author(s): Paul J. Der Mesropian, Gulvahid Shaikh, Emmanuelle Cordero Torres, Anum Bilal, Roy O. Mathew
      Hypertension is an important contributor to progression of nondiabetic chronic kidney disease (CKD). Compelling observational evidence indicates that the divergence of blood pressure (BP) away from an ideal range in either direction is associated with a progressive rise in the risk of mortality and cardiovascular and renal disease progression. To date, various clinical trials and meta-analyses examining strict versus less intensive BP control in nondiabetic CKD have not conclusively demonstrated a renal advantage of one BP-lowering approach over another, except in certain subgroups such as proteinuric patients where evidence is circumstantial. As recent data have come to light suggesting that intensive BP control yields superior survival and cardiovascular outcomes in patients at high risk for cardiovascular disease, interest in the prospect of whether such benefit extends to individuals with CKD has surged. This review is a comprehensive analysis of antihypertensive literature in nondiabetic renal disease, with a particular emphasis on BP target.
      Graphical abstract image

      PubDate: 2018-04-16T01:54:13Z
      DOI: 10.1016/j.jash.2018.01.005
       
  • Varying blood pressure in children: a diagnostic quandary interpreting the
           Fourth Report
    • Authors: Sheri L. Balsara; Joshua A. Samuels; Joyce P. Samuel; Cynthia S. Bell
      Pages: 190 - 194
      Abstract: Publication date: March 2018
      Source:Journal of the American Society of Hypertension, Volume 12, Issue 3
      Author(s): Sheri L. Balsara, Joshua A. Samuels, Joyce P. Samuel, Cynthia S. Bell
      Fourth Report guidelines on pediatric blood pressure (BP) are not clear when defining hypertension in children as “an average systolic BP and/or diastolic BP ≥ 95th percentile for gender, age, and height on ≥ 3 occasions.” We aimed to determine the prevalence of pediatric hypertension in a screening population based on two different guideline interpretations. Prevalence of hypertension among 2094 students at four Houston area schools was calculated based on the summation or sustained model definition from Fourth Report guidelines. Summation hypertension definition required the single average of the BPs recorded across three visits to be elevated. Sustained hypertension definition required BP at each of three visits to be elevated. Hypertension prevalence by the summation method was 7%, whereas sustained prevalence was only 3.3%. Nearly a quarter of students had varying BP and were not classifiable by the sustained method but most would be classified as normal or prehypertensive by the summation method. The prevalence of hypertension among adolescents doubled depending on the interpretation of Fourth Report guidelines. Although methods in research studies can be clearly examined on publication of results, it is unknown which interpretation method is being used in clinical practice.

      PubDate: 2018-04-16T01:54:13Z
      DOI: 10.1016/j.jash.2018.01.003
       
  • 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the
           Prevention, Detection, Evaluation, and Management of High Blood Pressure
           in Adults. A report of the American College of Cardiology/American Heart
           Association Task Force on Clinical Practice Guidelines
    • Authors: Robert D. Brook; Sanjay Rajagopalan
      First page: 238
      Abstract: Publication date: March 2018
      Source:Journal of the American Society of Hypertension, Volume 12, Issue 3
      Author(s): Robert D. Brook, Sanjay Rajagopalan


      PubDate: 2018-04-16T01:54:13Z
      DOI: 10.1016/j.jash.2018.01.004
       
  • Response to Letter to editor “2017
           ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the
           Prevention, Detection, Evaluation, and Management of High Blood Pressure
           in Adults”
    • Authors: Paul Muntner
      First page: 239
      Abstract: Publication date: March 2018
      Source:Journal of the American Society of Hypertension, Volume 12, Issue 3
      Author(s): Paul Muntner


      PubDate: 2018-04-16T01:54:13Z
      DOI: 10.1016/j.jash.2018.01.011
       
  • Editor’s page
    • Authors: Daniel Levy
      Abstract: Publication date: Available online 12 April 2018
      Source:Journal of the American Society of Hypertension
      Author(s): Daniel Levy


      PubDate: 2018-04-16T01:54:13Z
       
  • Ethanol withdrawal increases blood pressure and vascular oxidative stress:
           a role for angiotensin type 1 receptors
    • Authors: Natália A. Gonzaga; Gabriel T. do Vale; Juliana M. Parente; Rodrigo Yokota; Bruno S. De Martinis; Dulce E. Casarini; Michele M. Castro; Carlos R. Tirapelli
      Abstract: Publication date: Available online 4 April 2018
      Source:Journal of the American Society of Hypertension
      Author(s): Natália A. Gonzaga, Gabriel T. do Vale, Juliana M. Parente, Rodrigo Yokota, Bruno S. De Martinis, Dulce E. Casarini, Michele M. Castro, Carlos R. Tirapelli
      We evaluated the possible mechanisms underlying the oxidative stress induced by ethanol withdrawal. With this purpose, we verified the role of AT1 receptors in such response. Male Wistar rats were treated with ethanol 3-9% (vol./vol.) for 21 days. Ethanol withdrawal was induced by abrupt discontinuation of the treatment. Experiments were performed 48 h after ethanol discontinuation. Increased plasma levels of angiotensin II were detect after ethanol withdrawal. Losartan (10 mg/kg; p.o. gavage), a selective AT1 receptor antagonist impeded the increase in blood pressure induced by ethanol withdrawal. Increased lipoperoxidation and superoxide anion (O2 -) levels were detected in aortas after ethanol withdrawal and losartan prevented these responses. Decreased hydrogen peroxide (H2O2) and nitrate/nitrite (NOx) concentration were detected in aortas after ethanol withdrawal and losartan prevented these effects. Nitrotyrosine immunostaining in the rat aorta was increased after ethanol withdrawal and AT1 blockade impeded this response. Increased expression of PKCδ and p47phox was detected after ethanol withdrawal and treatment with losartan prevented these responses. Our study provides novel evidence that ethanol withdrawal increases vascular oxidative stress and hypertension through AT1-dependent mechanisms. These findings highlight the importance of angiotensin II in ethanol withdrawal-induced increase in blood pressure and vascular oxidative damage.

      PubDate: 2018-04-16T01:54:13Z
      DOI: 10.1016/j.jash.2018.03.012
       
  • Stroke and (or) myocardial infarction attributable to modifiable risk
           factors in Henan, China
    • Authors: Kaiyan Dong; Qian Yang; Fujiao Duan; Shuying Liang; Nan Ma; Wei Nie; Yali Yan; Ye Zhang; Rui Peng; Shuaibing Wang; Chunhua Song; Kaijuan Wang
      Abstract: Publication date: Available online 3 April 2018
      Source:Journal of the American Society of Hypertension
      Author(s): Kaiyan Dong, Qian Yang, Fujiao Duan, Shuying Liang, Nan Ma, Wei Nie, Yali Yan, Ye Zhang, Rui Peng, Shuaibing Wang, Chunhua Song, Kaijuan Wang
      Estimating population attributable risks (PARs) of potential modifiable risk factors for stroke and (or) myocardial infarction (MI) may be useful for planning cardiovascular disease (CVD) preventive strategies. A population of 17292 adults aged 18 years and older from a cross-sectional survey were included in the study. The binary logistic regression was used to evaluate the association between risk factors with disease events, then population attributable fraction (PAF) according to prevalence and odds ratios were calculated to identify and compare the effects at different subpopulations. We found that the main risk factor for CVD events was hypertension with about 50% of PAF; prehypertension (22.24%) only act at rural older females; the efficiency of low and moderate level physical activity were higher in males (over 20%) than females (under 20%); ever smoked contributed to CVDs in rural older populations (males, 19.25%; females, 5.57%) and urban younger males (54.52%); while as for high BMI, overweight (12.59%) only made contribution to rural males past sixty. In conclusion, hypertension control in the whole population, physical activity increasing in males and older females, smoking prevention in rural elders and urban younger males, and slimming in rural elder males might be effective to reduce the burden of CVDs in Henan.

      PubDate: 2018-04-16T01:54:13Z
      DOI: 10.1016/j.jash.2018.03.013
       
  • Significant Interaction of Hypertension and Homocysteine on Neurological
           Severity in First-ever Ischemic Stroke Patients
    • Authors: Ying-Li Fan; Rui Zhan; Yi-Fei Dong; Lei Huang; Xi-Xin Ji; Peng Lu; Jian Liu; Ping Li; Xiao-Shu Cheng
      Abstract: Publication date: Available online 3 April 2018
      Source:Journal of the American Society of Hypertension
      Author(s): Ying-Li Fan, Rui Zhan, Yi-Fei Dong, Lei Huang, Xi-Xin Ji, Peng Lu, Jian Liu, Ping Li, Xiao-Shu Cheng
      Background It is not known whether combination of hypertension and high homocysteine (HHcy) impacts on stroke-related neurological severity. Our aim was to determine whether there is an interaction of hypertension and HHcy on neurological severity in first-ever ischemic stroke patients. Methods and Results We analyzed neurological severity among 189 consecutive first-ever ischemic stroke patients with or without hypertension or HHcy. Hypertension [odds ratio (OR): 8.086, 95% confidence interval (CI): 3.596 to 18.181, P < 0.001] and total homocysteine (tHcy) (OR: 1.403, 95% CI: 1.247 to 1.579, P < 0.001) were independently associated with neurological severity. In receiver-operating characteristic analysis, tHcy was a significant predictor of neurological severity (area under curve 0.794; P < 0.001). A multiplicative interaction of hypertension and HHcy on more severe neurological severity was revealed by binary logistic regression (OR: 13.154, 95% CI: 5.293 to 32.691, P < 0.001). Analysis further identified a more than multiplicative interaction of hypertension and HHcy on neurological severity compared with patients without each condition (OR: 50.600, 95% CI: 14.775 to 173.285, P < 0.001). Interaction effect measured on an additive scale showed that 76.4% patients with moderate/severe neurological severity were attributed to interaction of hypertension and HHcy. Conclusions Significant interaction of hypertension and HHcy on neurological severity was found on multiplicative and additive scale in first-ever Chinese ischemic stroke patients.

      PubDate: 2018-04-16T01:54:13Z
      DOI: 10.1016/j.jash.2018.03.011
       
  • Dose-response relationship between visceral fat index and untreated
           hypertension in Chinese rural population: the RuralDiab study
    • Authors: Zhongyan Tian; Yuqian Li; Linlin Li; Xiaotian Liu; Yuanyuan Shi; Kaili Yang; Ruihua Liu; Honglei Zhang; Xinling Qian; Lei Yin; Jingzhi Zhao; Chongjian Wang
      Abstract: Publication date: Available online 29 March 2018
      Source:Journal of the American Society of Hypertension
      Author(s): Zhongyan Tian, Yuqian Li, Linlin Li, Xiaotian Liu, Yuanyuan Shi, Kaili Yang, Ruihua Liu, Honglei Zhang, Xinling Qian, Lei Yin, Jingzhi Zhao, Chongjian Wang
      The study aimed to explore the association of visceral fat index (VFI) with untreated hypertension in different genders, and evaluate the practicability of VFI as a marker for discriminating untreated hypertension in Chinese rural population. A total of 12536 eligible participants aged 35 years and over were derived from the RuralDiab study in China. VFI was assessed with bioelectrical impendence methods, and divided into sex-specific quartiles. Logistic regression and restricted cubic spline regression were performed. Receiver Operating Characteristic (ROC) curve was applied to analyze the discriminating performance of VFI. Meanwhile, a meta-analysis was conducted to validate the result of this study. Compared with the lowest VFI quartile, the adjusted odds ratios(ORs) and 95% confidence interval(95% CI) in the highest VFI quartile were 3.68(2.91-4.66) in male and 2.63(2.12-3.25) in female (P trend < 0.01). Nonlinear increasing trends about the risk of untreated hypertension were observed with the continuously increasing VFI in both genders (P linearity < 0. 01). The sensitivity and specificity in the optimal cut-off values for VFI were 58.37%, 62.26% in male and 49.09%, 66.67% in female. The AUCs(95% CI) were 0.64(0.63-0.66) in male and 0.61(0.60-0.62) in female. Meta-analysis results displayed the pooled ORs(95% CI) were 2.65(1.79-3.93) in male and 2.27(1.74-2.95) in female.VFI was significantly positively correlated with the risk of untreated hypertension, and dose-response relationships were observed in both genders in Chinese rural population. However, VFI as a marker had limited potential for discriminating untreated hypertension.

      PubDate: 2018-04-16T01:54:13Z
      DOI: 10.1016/j.jash.2018.03.009
       
  • Comparison of three formulas to estimate 24-hour urinary sodium and
           potassium excretion in patients hospitalized in a hypertension unit
    • Authors: Piotr Jędrusik; Bartosz Symonides; Zbigniew Gaciong
      Abstract: Publication date: Available online 28 March 2018
      Source:Journal of the American Society of Hypertension
      Author(s): Piotr Jędrusik, Bartosz Symonides, Zbigniew Gaciong
      Background Measurements of 24-hour urinary sodium (24hrUNa) and potassium (24hrUK) excretion are useful in hypertensives but 24-hour urine collection may be difficult or unreliable. We compared three formulas (Tanaka, Kawasaki, PAHO) proposed to estimate 24hrUNa and 24hrUK based on spot urine measurements. Methods We studied 382 patients admitted to a hypertension unit. Sodium, potassium, and creatinine levels were measured using standard laboratory methods in a morning urine sample, followed by 24-hour urinary collection. Agreement between estimated and measured 24hrUNa and 24hrUK was evaluated using the Pearson correlation and Bland-Altman plots. Results Measured 24hrUNa was 158±75 mmol/d and 24hrUK was 54±24 mmol/d. The correlation coefficient was r=0.53 for estimated vs. measured 24hrUNa, r=0.69-0.73 for estimated vs. measured 24hrUK (all P<0.001). The mean bias for 24hrUNa was significantly smaller for Tanaka (10.5 mmol/d) and PAHO (11.5 mmol/d) compared to Kawasaki formula (-29.9 mmol/d). The mean bias for 24hrUK was significantly smaller for Kawasaki (7.3 mmol/d) and PAHO (8.3 mmol/d) compared to Tanaka formula (16.5 mmol/d). Conclusion Using a single morning urine sample, we found the PAHO formula to be the best for predicting mean 24hrUK and 24hrUNa in hospitalized hypertensive patients. However, precision and accuracy of all the evaluated formulas was inadequate.

      PubDate: 2018-04-16T01:54:13Z
      DOI: 10.1016/j.jash.2018.03.010
       
  • Integrated flow-mediated vasodilation response predicts cardiovascular
           events in elderly patients with cardiovascular risk factors: the Japan
           Morning Surge–Home Blood Pressure study
    • Authors: Tomoyuki Kabutoya; Satoshi Hoshide; Kazuomi Kario
      Abstract: Publication date: Available online 21 March 2018
      Source:Journal of the American Society of Hypertension
      Author(s): Tomoyuki Kabutoya, Satoshi Hoshide, Kazuomi Kario
      The integrated flow-mediated vasodilation (FMD) response has been associated with cardiovascular (CV) risk factors, but the association between the integrated FMD response and subsequent CV events has been unclear. We enrolled 555 patients who had at least one CV risk factor (hypertension, dyslipidemia, diabetes, or smoking). We measured the peak percentage change in diameter (ΔFMD), and integrated FMD response calculated as the area under the dilation curve over a 120-second dilation period (FMD-AUC120). Elderly patients (age ≥ 65 years, N = 270) in the lowest tertile of FMD-AUC120 (FMD-AUC120 < 5.6) had a higher rate of CV events compared with those in the two higher tertiles (FMD-AUC120 ≥ 5.6) (log rank 4.15, P = .041). The association remained significant after adjusting for covariates (hazard ratio 3.84, P = .007). In the 285 middle-aged patients (age < 65 years), the CV event rates were similar between patients in the lowest tertile and those in the two higher tertiles of FMD-AUC120 (log rank 0.39, P = .53). The CV event rates were similar between patients in the lowest tertile and those in the two higher tertiles of ΔFMD in elderly and middle-aged patient groups. In conclusion, integrated flow-mediated vasodilation response, but not ΔFMD, predicted CV events in elderly patients with CV risk factors.

      PubDate: 2018-04-16T01:54:13Z
      DOI: 10.1016/j.jash.2018.03.006
       
  • Rationale and evidence for the development of a durable device-based
           cardiac neuromodulation therapy for hypertension
    • Authors: Bing Yang; Yue Wang; Fengxiang Zhang; Weizhu Ju; Hongwu Chen; Yuval Mika; Ricardo Aviv; Steven J. Evans; Daniel Burkhoff; Jie Wang; Minglong Chen
      Abstract: Publication date: Available online 21 March 2018
      Source:Journal of the American Society of Hypertension
      Author(s): Bing Yang, Yue Wang, Fengxiang Zhang, Weizhu Ju, Hongwu Chen, Yuval Mika, Ricardo Aviv, Steven J. Evans, Daniel Burkhoff, Jie Wang, Minglong Chen
      We assessed the feasibility of achieving acute, sustained blood pressure reductions through the use of cardiac pacing algorithms delivered via standard dual-chamber pacing based on introducing short atrio-ventricular (AV) delays (SAVD). Eighteen hypertensive subjects (57.3 ± 9.8 years old; 10 male and 8 female) with average initial systolic and diastolic blood pressures of 151.2 ± 17.6/92.2 ± 12.7 mmHg already scheduled to undergo an invasive electrophysiology procedure were included in this study. Pacing sequences were applied for ∼1-minute intervals with AV delays of 80, 40, 20 and 2 ms, while making high fidelity blood pressure measurements. Average reductions of 19.6 ± 7.7 mmHg in systolic pressure and 4.3 ± 3.8 mmHg in diastolic pressure (P < .001 each) were demonstrated with 2 ms AV delay pacing. Initial SBP reductions were followed by rebound effects which diminished the SBP reducing effects of SAVD pacing, likely due to baroceptor activation causing increased peripheral resistance. This effect was eliminated by intermittent introduction of longer AV delay pacing which modulated the baroreflexes. These findings provide the rationale and evidence underlying recent data showing significant and long-term blood pressure reductions in response to this cardiac neuromodulation therapy in hypertensive patients despite medical therapy.

      PubDate: 2018-04-16T01:54:13Z
      DOI: 10.1016/j.jash.2018.03.004
       
  • Vascular toxicities with VEGF inhibitor therapies - Focus on Hypertension
           and Arterial Thrombotic Events
    • Authors: Rhian M. Touyz; Sandra Herrmann; Joerg Herrmann
      Abstract: Publication date: Available online 21 March 2018
      Source:Journal of the American Society of Hypertension
      Author(s): Rhian M. Touyz, Sandra Herrmann, Joerg Herrmann
      The vascular endothelial growth factor (VEGF) signalling pathway (VSP) fulfils a cardinal role in endothelial cells and its inhibition has profound cardiovascular impact. This is true not only for the normal vasculature but also for the tumor vasculature when VSP inhibitors are used as anti-angiogenic therapies. Generalized endothelial dysfunction predisposes to vasoconstriction, atherosclerosis, platelet activation, and thrombosis (arterial more than venous). All of these have been reported with VSP inhibitors and collectively give rise to vascular toxicities, the most concerning of which are arterial thromboembolic events (ATE). VSP inhibitors include antibodies, acting extracelluarly on VEGF, such as bevacizumab and tyrosine kinases inhibitors (TKIs), acting intracellularly on the kinase domain of VEGF receptors, such as sunintib and sorafenib. The addition of bevacizumab and VSP TKI therapy to the cancer treatment regimen is associated with a 1.5-2.5-fold and 2.3-4.6-fold increase risk of ATEs, respectively. Risk factors for ATEs while on VSP inhibitor therapy include age older than 65 years, previous thromboembolic events, history of atherosclerotic disease and duration of VSP inhibitor therapy. In clinical practice, hypertension remains the most commonly noted vascular manifestation of VSP inhibition. Optimal blood pressure goals and preferred therapeutic strategies towards reaching these goals are not defined at present. This review summarizes current data on this topic and proposes a more intensive management approach to patients undergoing VSP inhibitor therapy including SPRINT trial blood pressure goals, pleiotropic vasoprotective agents such as ACE inhibitors, amlodipine, and carvedilol, high dose statin therapy, and aspirin.
      Graphical abstract image

      PubDate: 2018-04-16T01:54:13Z
      DOI: 10.1016/j.jash.2018.03.008
       
  • Mesenchymal stem cell derived microvesicles alleviate pulmonary arterial
           hypertension by regulating renin angiotensin system
    • Authors: Zhenjun Liu; Jinghu Liu; Mengyuan Xiao; Junxian Wang; Feng Yao; Weikai Zeng; Liqin Yu; Yuejie Guan; Wenyan Wei; Zijian Peng; Kunpeng Zhu; Jin Wang; Zhongyuan Yang; Jixin Zhong; Jianying Chen
      Abstract: Publication date: Available online 15 March 2018
      Source:Journal of the American Society of Hypertension
      Author(s): Zhenjun Liu, Jinghu Liu, Mengyuan Xiao, Junxian Wang, Feng Yao, Weikai Zeng, Liqin Yu, Yuejie Guan, Wenyan Wei, Zijian Peng, Kunpeng Zhu, Jin Wang, Zhongyuan Yang, Jixin Zhong, Jianying Chen
      Background In recent years, microvesicles derived from mesenchymal stem cells (MSCs) have been proved to be able to improve the outcome of pulmonary arterial hypertension (PAH) in many respects, but the underlying mechanisms of it still remain unclear. Since the renin angiotensin system (RAS) has been found to be closely related to PAH, the present study was designed to investigate whether the effect of MSC-derived microvesicles on PAH was correlated with RAS. Methods Microvesicles (MVs) were isolated and purified from bone marrow mesenchymal stem cells. PAH rat models were established by a single intraperitoneal injection of 1% monocrotaline (50mg/Kg). In vivo study, after 3 weeks of MCT exposure, Nor group and PAH group were injected with 0.5ml saline every two days through tail vein while MVs group was injected with 0.5ml saline containing 30ug microvesicles and A-779+MVs group injected with 0.5ml saline containing 120ug A-779 and 30ug microvesicles until 5 weeks of MCT exposure. Whereafter all the groups were analyzed for hemodynamic evaluation, right ventricular hypertrophy index (RVHI), pulmonary vessel wall thickness index (TI) and pulmonary vessel lumen area index (AI), the inflammation score (IS), the collagen fiber volume fraction, the levels of Ang-(1-7) and Ang-Ⅱin plasma and lung tissue, the mRNA levels of ACE2 and ACE in the lung tissue. Results Microvesicles (MVs) derived from mesenchymal stem cells relieved the pulmonary artery pressure, right ventricular hypertrophy index, pulmonary vessel wall thickness index, pulmonary vessel lumen area index, the inflammation score and the collagen fiber volume fraction. Moreover, in MVs group, ACE2 mRNA in the lung tissues and plasma levels of Ang-(1-7) were both upregulated compared with PAH group. On the contrary, ACE and Ang-II were decreased compared with PAH group. However, the enhanced protective effects observed in MVs group were diminished by the use of A-779, an inhibitor of Mas receptor in ACE2-Ang-(1-7)-Mas axis. Conclusions Microvesicles derived from bone marrow mesenchymal stem cells (BMMSCs) can exert beneficial effects against MCT-induced PAH in vivo, meanwhile shifting the balance from ACE-Ang-II-AT1R axis toward the ACE2-Ang-(1–7)-Mas axis, which might be one of the possible therapeutic mechanisms for microvesicles sub-cellular treatment.

      PubDate: 2018-04-16T01:54:13Z
      DOI: 10.1016/j.jash.2018.02.006
       
  • Cadmium body burden, hypertension, and changes in blood pressure over
           time: results from a prospective cohort study in American Indians
    • Authors: Clare Oliver-Williams; Annie Green Howard; Ana Navas-Acien; Barbara V. Howard; Maria Tellez-Plaza; Nora Franceschini
      Abstract: Publication date: Available online 10 March 2018
      Source:Journal of the American Society of Hypertension
      Author(s): Clare Oliver-Williams, Annie Green Howard, Ana Navas-Acien, Barbara V. Howard, Maria Tellez-Plaza, Nora Franceschini
      American Indian communities are at greater risk of hypertension and cardiovascular disease than the general US population and are exposed to greater cadmium levels. However, cadmium's effect on blood pressure is unclear. This study assesses the association between baseline urinary cadmium and longitudinal changes in blood pressure in American Indian communities. Cadmium was measured in 3047 baseline urine samples from Strong Heart Study participants from three geographic areas. Longitudinal changes in blood pressure across three study visits (1989–1999) were modeled using linear mixed models by baseline log urinary cadmium to creatinine ratio. Hypertension risk was evaluated using interval-censored survival analysis. Higher levels of urinary cadmium at baseline were associated with faster rates of increase in diastolic and systolic blood pressure (P [trend] = .001 and .02, respectively). The estimated change in diastolic and systolic blood pressures per year was 0.18 mm Hg (0.05–0.31) and 0.62 mm Hg (0.37–0.87) in the upper quintile of cadmium level compared with −0.11 mm Hg (−0.24 to 0.02) and 0.21 mm Hg (−0.04 to 0.46) in the lowest, respectively. A one-unit increase in log-transformed urinary cadmium was associated with 10% greater hypertension risk (95% confidence interval: 1.01–1.20). In conclusion, blood pressure of individuals with greater baseline levels of urinary cadmium increased at a faster rate relative to those with lower levels.

      PubDate: 2018-04-16T01:54:13Z
      DOI: 10.1016/j.jash.2018.03.002
       
  • Can a polypill one single tablet combat different cardiovascular risk
           factors'
    • Authors: Talma Rosenthal
      Abstract: Publication date: Available online 2 March 2018
      Source:Journal of the American Society of Hypertension
      Author(s): Talma Rosenthal
      Polypharmacy is defined as the use of two or more drugs simultaneously. Cardiovascular drugs and antihypertensives are commonly prescribed for treatment of cardiovascular disease (CVD), especially in elderly patients. Recent studies in patients with a history of CVD demonstrated that the fixed-dose combination of cardiovascular drugs in a polypill retain their individual efficacy, safety, and tolerability, thus have the potential to improve medication adherence and multiple risk factor control, thereby improving patient outcomes in secondary cardiovascular prevention. Since the initial conception of the fixed-dose polypill, just over a decade ago, only six large randomized trials assessing the efficacy and safety of this innovative concept have been completed (one is still ongoing). The results demonstrate that the polypill therapy significantly improved adherence, lowered systolic blood pressure, and low-density lipoprotein cholesterol, compared with usual care, in patients at high risk for CVD, especially among those who were undertreated at baseline. Correspondingly, further studies showed that the strengths of the polypill include better adherence, equivalent or better risk factor control, and improved quality of life among polypill users, as compared with usual care. However, the long-term outcome of the polypill on CVD events and mortality are unavailable and are currently being studied in clinical trials.

      PubDate: 2018-04-16T01:54:13Z
      DOI: 10.1016/j.jash.2018.02.008
       
  • From the Editor
    • Authors: Daniel Levy
      Abstract: Publication date: Available online 2 March 2018
      Source:Journal of the American Society of Hypertension
      Author(s): Daniel Levy


      PubDate: 2018-04-16T01:54:13Z
       
  • From the Editor
    • Authors: Daniel Levy
      Abstract: Publication date: March 2018
      Source:Journal of the American Society of Hypertension, Volume 12, Issue 3
      Author(s): Daniel Levy


      PubDate: 2018-04-16T01:54:13Z
       
  • Notice of concern
    • Abstract: Publication date: March 2018
      Source:Journal of the American Society of Hypertension, Volume 12, Issue 3


      PubDate: 2018-04-16T01:54:13Z
       
  • Instructions for Authors
    • Abstract: Publication date: March 2018
      Source:Journal of the American Society of Hypertension, Volume 12, Issue 3


      PubDate: 2018-04-16T01:54:13Z
       
  • Impact of masked hypertension on diabetic nephropathy in patients with
           type II diabetes: a KAMOGAWA-HBP study
    • Authors: Emi Ushigome; Chikako Oyabu; Toru Tanaka; Goji Hasegawa; Masayoshi Ohnishi; Sei Tsunoda; Hidetaka Ushigome; Isao Yokota; Naoto Nakamura; Yohei Oda; Mai Asano; Muhei Tanaka; Masahiro Yamazaki; Michiaki Fukui
      Abstract: Publication date: Available online 1 March 2018
      Source:Journal of the American Society of Hypertension
      Author(s): Emi Ushigome, Chikako Oyabu, Toru Tanaka, Goji Hasegawa, Masayoshi Ohnishi, Sei Tsunoda, Hidetaka Ushigome, Isao Yokota, Naoto Nakamura, Yohei Oda, Mai Asano, Muhei Tanaka, Masahiro Yamazaki, Michiaki Fukui
      The prognostic significance of masked hypertension (MH) on the progression of diabetic nephropathy among patients with type II diabetes is not well documented. We examined the relationship between clinic systolic blood pressure (SBP) and morning home SBP measurements and progression to macroalbuminuria in patients with type II diabetes. We analyzed prospective cohort study data from 712 patients with type II diabetes. We classified the patients into the following four groups according to their clinic (130 mm Hg) and home (125 mm Hg) SBP measurements: controlled blood pressure group, white-coat hypertension group, MH group, and sustained hypertension (SH) group. The patients were instructed to perform triplicate morning and evening blood pressure measurements for 14 consecutive days. During the 2-year follow-up period, 23 patients progressed to macroalbuminuria. The unadjusted odds ratio (95% confidence interval) for progression to macroalbuminuria among the patients with MH was significantly higher than that among the patients with controlled blood pressure (8.89 [1.06–74.88]). No significant relationship was observed between white-coat hypertension or SH and progression to macroalbuminuria. In analyses adjusted for various potential confounders, the adjusted odds ratio for progression to macroalbuminuria in the MH group was more than 8-fold higher than that in the controlled blood pressure group. MH might be a predictor of progression to macroalbuminuria among patients with type II diabetes. This rate of progression is comparable with or greater than the results reported for patients with SH.

      PubDate: 2018-04-16T01:54:13Z
      DOI: 10.1016/j.jash.2018.02.005
       
  • Circulating bone morphogenetic protein-9 levels are associated with
           hypertension and insulin resistance in humans
    • Authors: Hong Huang; Wei Wang; Gangyi Yang; Yu Zhang; Xiaoqiang Li; Hua Liu; Lin Zhang; Hongting Zheng; Ling Li
      Abstract: Publication date: Available online 1 March 2018
      Source:Journal of the American Society of Hypertension
      Author(s): Hong Huang, Wei Wang, Gangyi Yang, Yu Zhang, Xiaoqiang Li, Hua Liu, Lin Zhang, Hongting Zheng, Ling Li
      It has been demonstrated that bone morphogenetic protein-9 (BMP-9) may have an important role in vascular development and stability. However, the association of circulating BMP-9 with essential hypertension (HTN) has not been established in humans. The objective of this study is to observe the changes of circulating BMP-9 levels in patients with HTN and to investigate the association of circulation BMP-9 and insulin resistance (IR) in a cross-sectional study. Two hundred twenty-five individuals, including 132 patients with hypertension, and 93 healthy controls, were included in the present study. Circulating BMP-9 concentrations were measured with an ELISA kit. The association of circulating BMP-9 with other parameters was analyzed. When compared with healthy subjects, circulating BMP-9 concentrations were markedly lower in HTN patients (46.20 [31.85–62.80] vs. 77.21 [39.33–189.15], P < .01) and correlated negatively with blood pressure and the homeostasis model assessment of insulin resistance (P < .05 or P < .01). Decreasing levels of BMP-9 were independently and markedly related to HTN. In a multiple linear regression analysis, only systolic blood pressure and free fatty acid concentrations were independently associated with circulating BMP-9. Our findings suggest that BMP-9 may be a serum biomarker for HTN and IR.

      PubDate: 2018-04-16T01:54:13Z
      DOI: 10.1016/j.jash.2018.02.007
       
  • The relationship of depression with the level of blood pressure in
           population-based Kangbuk Samsung Health Study
    • Authors: Sung Keun Park; Ju Young Jung; Jae-Hong Ryoo; Chang-Mo Oh; Jae-Hon Lee; Zihang Pan; Rodrigo B. Mansur; Margarita Shekotikhina; Roger S. McIntyre; Joong-Myung Choi
      Abstract: Publication date: Available online 16 February 2018
      Source:Journal of the American Society of Hypertension
      Author(s): Sung Keun Park, Ju Young Jung, Jae-Hong Ryoo, Chang-Mo Oh, Jae-Hon Lee, Zihang Pan, Rodrigo B. Mansur, Margarita Shekotikhina, Roger S. McIntyre, Joong-Myung Choi
      There has been increasing evidence about psychosomatic relationship between mood disorder and blood pressure (BP). However, the degree to which BP categories are associated with depression has been less well described. Thus, this study was to investigate the association of depression with BP categories. A total of 90,643 men and 68,933 women were enrolled in this study. They were stratified into four groups (normal, prehypertension, newly diagnosed hypertension, and recognized hypertension) according to the BP levels and the history of hypertension. Center for Epidemiological Studies–Depression was used to evaluate the depressive symptom, and the degree of depression was evaluated by the cutoff of Center for Epidemiological Studies–Depression (mild: 16–20, moderate: 21–24, severe: ≥25). The multivariate logistic regression was used in calculating odds ratios for depression according to the four BP categories, with adjustment for multiple confounding factors. Subgroup analysis was conducted by gender and age. The adjusted odds ratios for depression tended to decrease from normal to newly diagnosed hypertension, but significantly increased in recognized hypertension (normal: reference, prehypertension: 0.85 [0.80–0.91], newly diagnosed hypertension: 0.75 [0.65–0.86], recognized hypertension: 1.11 [1.03–1.20]). Subgroup analysis also indicated the similar pattern of relationship, which was more prominent in male and middle-aged subgroup than any other subgroups. Depression was inversely associated with elevated BP. However, recognized hypertension had the increased likelihood of depression in male and young age group. These findings suggest that the association between depression and BP may be moderated by the chronicity of hypertension in men and young individuals.

      PubDate: 2018-04-16T01:54:13Z
      DOI: 10.1016/j.jash.2018.02.004
       
  • Effects on repetitive 24-hour ambulatory blood pressure in subjects with
           type II diabetes randomized to liraglutide or glimepiride treatment both
           in combination with metformin: a randomized open parallel-group study
    • Authors: Johan Jendle; Xin Fang; Yang Cao; Leif Bojö; Bo K. Nilsson; Fredric Hedberg; Irene Santos-Pardo; Thomas Nyström
      Abstract: Publication date: Available online 16 February 2018
      Source:Journal of the American Society of Hypertension
      Author(s): Johan Jendle, Xin Fang, Yang Cao, Leif Bojö, Bo K. Nilsson, Fredric Hedberg, Irene Santos-Pardo, Thomas Nyström
      In this post hoc study, we aimed to investigate liraglutide treatment on repetitive 24-hour blood pressure (BP) in patients with type II diabetes. Sixty-two individuals with type II diabetes (45 males) were randomized to 1.8 mg liraglutide once daily or 4 mg glimepiride together with 1 g metformin twice daily. Ambulatory 24-hour systolic and diastolic blood pressure (sBP/dBP) was repetitively measured at baseline, 2 weeks, and 18 weeks. Outcomes were evaluated as treatment change from baseline, 2 weeks, and 18 weeks. Baseline clinical characteristics of liraglutide (n = 33) and glimepiride (n = 29) groups were well matched. No statistically significant difference in 24-hour sBP/dBP between three time periods and groups was observed. There was no treatment change for 24-hour sBP at week 2 or after week 18. There was a transient treatment change in 24-hour dBP in the liraglutide group at week 2 (3.2 ± 5.4 vs. −1.2 ± 4.5 mm Hg, P < .01). A treatment change in 24-hour heart rate at week 2 (4.9 ± 6.8 vs. 1.0 ± 6.0 bpm, P = .03) and at week 18 (5.9 ± 7.8 vs. 0.2 ± 6.3 bpm, P < .01) was observed in the liraglutide group. In conclusion, liraglutide treatment did not lower BP. However, a small diurnal variation in dBP without affecting BP variability or nocturnal BP dipping was observed.

      PubDate: 2018-04-16T01:54:13Z
      DOI: 10.1016/j.jash.2018.02.003
       
  • Comparison of laboratory and ambulatory measures of central blood pressure
           and pulse wave reflection: hitting the target or missing the mark'
    • Authors: Matthew J. Burns; Jeremy D. Seed; Anthony V. Incognito; Connor J. Doherty; Karambir Notay; Philip J. Millar
      Abstract: Publication date: Available online 10 February 2018
      Source:Journal of the American Society of Hypertension
      Author(s): Matthew J. Burns, Jeremy D. Seed, Anthony V. Incognito, Connor J. Doherty, Karambir Notay, Philip J. Millar
      Prior studies demonstrating clinical significance of noninvasive estimates of central blood pressure (BP) and pulse wave reflection have relied primarily on discrete resting measures. The aim of this study was to compare central BP and pulse wave reflection measures sampled during a single resting laboratory visit against those obtained under ambulatory conditions. The secondary aim was to investigate the reproducibility of ambulatory central BP and pulse wave reflection measurements. Forty healthy participants (21 males; 24 ± 3 years) completed three measurements of brachial artery pulse wave analysis (Oscar 2 with SphygmoCor Inside) in the laboratory followed by 24 hours of ambulatory monitoring. Seventeen participants repeated the 24-hour ambulatory monitoring visit after at least 1 week. Ambulatory measures were divided into daytime (9 AM–9 PM), nighttime (1 AM–6 AM), and 24-hour periods. Compared with laboratory measurements, central systolic BP, augmentation pressure, and augmentation index (with and without heart rate normalization) were higher (all P < .01) during daytime and 24-hour periods but lower during the nighttime period (all P < .001). The drop in nighttime brachial systolic BP was larger than central systolic pressure (Δ −20 ± 6 vs. −15 ± 6 mm Hg; P < .0001). Repeat ambulatory measurements of central BP and pulse wave reflection displayed good-to-excellent intraclass correlation coefficients (r = 0.58–0.86; all P < .01), although measures of pulse wave reflection had higher coefficients of variation (14%–41%). The results highlight absolute differences in central BP and pulse wave reflection between discrete laboratory and ambulatory conditions. The use of ambulatory measures of central BP and pulse wave reflection warrant further investigation for clinical prognostic value.

      PubDate: 2018-04-16T01:54:13Z
      DOI: 10.1016/j.jash.2018.01.014
       
  • Home blood pressure–guided antihypertensive therapy in chronic kidney
           disease: more data are needed
    • Authors: Panagiotis I. Georgianos; Eleni Champidou; Vassilios Liakopoulos; Elias V. Balaskas; Pantelis E. Zebekakis
      Abstract: Publication date: Available online 10 February 2018
      Source:Journal of the American Society of Hypertension
      Author(s): Panagiotis I. Georgianos, Eleni Champidou, Vassilios Liakopoulos, Elias V. Balaskas, Pantelis E. Zebekakis
      In the era of newly introduced hypertension guidelines recommending lower blood pressure (BP) targets for drug-treated hypertensives, the necessity for optimized management of hypertension becomes even more urgent. The concept of home BP–guided antihypertensive therapy is for long suggested as a simple and feasible approach to improve BP control rates and optimize the management of hypertension. Home BP–guided antihypertensive therapy is particularly applicable to hypertensives with chronic kidney disease (CKD) for several reasons including the following: (1) difficult-to-control BP and high BP variability in the CKD setting; (2) poor accuracy of office BP in determining hypertension control status and detecting “white-coat” and “masked” hypertension; (3) poor value of routine office BP recordings in predicting the longitudinal progression of target-organ damage; and (4) superiority of home BP over office BP recordings in prognosticating the risk of incident end-stage renal disease or death. The concept of home BP–guided antihypertensive therapy is even more relevant for those on hemodialysis, given the high intradialytic and interdialytic BP variability and poor value of conventional peridialytic BP recordings in estimating the actual BP load recorded outside of dialysis with the use of home or ambulatory BP monitoring. Randomized trials comparing home BP–guided antihypertensive therapy versus usual care are warranted to prove the feasibility and effectiveness of this therapeutic approach and convince clinicians for using home BP monitoring as the standard of care when managing hypertension, particularly in people with CKD or end-stage renal disease.

      PubDate: 2018-04-16T01:54:13Z
      DOI: 10.1016/j.jash.2018.02.002
       
  • Elevated preoperative blood pressures in adult surgical patients are
           highly predictive of elevated home blood pressures
    • Authors: Robert B. Schonberger; Adambeke Nwozuzu; Jill Zafar; Eric Chen; Simon Kigwana; Miriam M. Monteiro; Jean Charchaflieh; Sophisa Sophanphattana; Feng Dai; Matthew M. Burg
      Abstract: Publication date: Available online 6 February 2018
      Source:Journal of the American Society of Hypertension
      Author(s): Robert B. Schonberger, Adambeke Nwozuzu, Jill Zafar, Eric Chen, Simon Kigwana, Miriam M. Monteiro, Jean Charchaflieh, Sophisa Sophanphattana, Feng Dai, Matthew M. Burg
      Blood pressure (BP) measurement during the presurgical assessment has been suggested as a way to improve longitudinal detection and treatment of hypertension. The relationship between BP measured during this assessment and home blood pressure (HBP), a better indicator of hypertension, is unknown. The purpose of the present study was to determine the positive predictive value of presurgical BP for predicting elevated HBP. We prospectively enrolled 200 patients at a presurgical evaluation clinic with clinic blood pressures (CBPs) ≥130/85 mm Hg, as measured using a previously validated automated upper-arm device (Welch Allyn Vital Sign Monitor 6000 Series), to undergo daily HBP monitoring (Omron Model BP742N) between the index clinic visit and their day of surgery. Elevated HBP was defined, per American Heart Association guidelines, as mean systolic HBP ≥135 mm Hg or mean diastolic HBP ≥85 mm Hg. Of the 200 participants, 188 (94%) returned their home blood pressure monitors with valid data. The median number of HBP recordings was 10 (interquartile range, 7–14). Presurgical CBP thresholds of 140/90, 150/95, and 160/100 mm Hg yielded positive predictive values (95% confidence interval) for elevated HBP of 84.1% (0.78–0.89), 87.5% (0.81–0.92), and 94.6% (0.87–0.99), respectively. In contrast, self-reported BP control, antihypertensive treatment, availability of primary care, and preoperative pain scores demonstrated poor agreement with elevated HBP. Elevated preoperative CBP is highly predictive of longitudinally elevated HBP. BP measurement during presurgical assessment may provide a way to improve longitudinal detection and treatment of hypertension.

      PubDate: 2018-04-16T01:54:13Z
      DOI: 10.1016/j.jash.2018.01.012
       
  • Exercise and other nonpharmacological strategies to reduce blood pressure
           in older adults: a systematic review and meta-analysis
    • Authors: Philip J.J. Herrod; Brett Doleman; James E.M. Blackwell; Francesca O’Boyle; John P. Williams; Jonathan N. Lund; Bethan E. Phillips
      Abstract: Publication date: Available online 2 February 2018
      Source:Journal of the American Society of Hypertension
      Author(s): Philip J.J. Herrod, Brett Doleman, James E.M. Blackwell, Francesca O’Boyle, John P. Williams, Jonathan N. Lund, Bethan E. Phillips
      The incidence of hypertension increases with advancing age and represents a significant burden of disease. Lifestyle modification represents the first-line intervention in treatment algorithms; however, the majority of evidence for this comes from studies involving young participants using interventions that may not always be feasible in the elderly. This manuscript presents a systematic review of all randomized controlled trials involving participants with a mean age of 65 or over investigating nonpharmacological strategies to reduce blood pressure (BP). Fifty-three randomized controlled trials were included. The majority of interventions described aerobic exercise training, dynamic resistance exercise training, or combined aerobic and dynamic resistance exercise training (COM), with limited studies reporting isometric exercise training or alternative lifestyle strategies. Aerobic exercise training, dynamic resistance exercise training, COM, and isometric exercise training all elicited significant reductions in both systolic and diastolic BP, with no additional benefit of COM compared with single modality exercise training. Three months of traditional exercise-based lifestyle intervention may produce a reduction in BP of approximately 5 mmHg systolic and 3 mmHg diastolic in older individuals, similar to that expected in younger individuals.

      PubDate: 2018-04-16T01:54:13Z
      DOI: 10.1016/j.jash.2018.01.008
       
  • Diets containing salmon fillet delay development of high blood pressure
           and hyperfusion damage in kidneys in obese Zucker fa/fa rats
    • Authors: Linn A. Vikøren; Aslaug Drotningsvik; Angela Mwakimonga; Sabine Leh; Gunnar Mellgren; Oddrun A. Gudbrandsen
      Abstract: Publication date: Available online 2 February 2018
      Source:Journal of the American Society of Hypertension
      Author(s): Linn A. Vikøren, Aslaug Drotningsvik, Angela Mwakimonga, Sabine Leh, Gunnar Mellgren, Oddrun A. Gudbrandsen
      Hypertension is the leading risk factor for cardiovascular and chronic renal diseases, affecting more than 1 billion people. Fish intake is inversely correlated with the prevalence of hypertension in several, but not all, studies, and intake of fish oil and fish proteins has shown promising potential to delay development of high blood pressure in rats. The effects of baked and raw salmon fillet intake on blood pressure and renal function were investigated in obese Zucker fa/fa rats, which spontaneously develop hypertension with proteinuria and renal failure. Rats were fed diets containing baked or raw salmon fillet in an amount corresponding to 25% of total protein from salmon and 75% of protein from casein, or casein as the sole protein source (control group) for 4 weeks. Results show lower blood pressure and lower urine concentrations of albumin and cystatin C (relative to creatinine) in salmon diet groups when compared to control group. Morphological examinations revealed less prominent hyperfusion damage in podocytes from rats fed diets containing baked or raw salmon when compared to control rats. In conclusion, diets containing baked or raw salmon fillet delayed the development of hypertension and protected against podocyte damage in obese Zucker fa/fa rats.

      PubDate: 2018-04-16T01:54:13Z
      DOI: 10.1016/j.jash.2018.01.006
       
  • A randomized controlled trial comparing home-based isometric handgrip
           exercise versus endurance training for blood pressure management
    • Authors: Karla Fabiana Goessler; Roselien Buys; Dieter VanderTrappen; Lise Vanhumbeeck; Veronique Ann Cornelissen
      Abstract: Publication date: Available online 2 February 2018
      Source:Journal of the American Society of Hypertension
      Author(s): Karla Fabiana Goessler, Roselien Buys, Dieter VanderTrappen, Lise Vanhumbeeck, Veronique Ann Cornelissen
      Aerobic endurance exercise (AEX) is an effective treatment in the prevention and management of high blood pressure (BP). Growing evidence suggests potential benefits from isometric handgrip (IHG) exercise, which may promote similar or even larger reductions in BP than AEX. We compared the effects of home-based AEX and home-based IHG on BP. Sixty healthy individuals (31 men; mean age, 33.1 years; mean BP, 126.9 ± 1.6/84.7 ± 1.1 mm Hg) were randomized to IHG, AEX, or a control group. Both exercise interventions were performed in the home environment. The IHG group performed daily 4 × 2 minutes sustained grips at 30% of maximal volitional contraction. Participants in the AEX group were advised to perform at least 150 min/wk of aerobic exercise at moderate intensity. Outcome measurements were assessed at baseline and 8 weeks of follow-up. Compared with the control group, AEX resulted in a larger reduction in ambulatory BP; both AEX and IHG exercise tended to induce larger reductions in office systolic BP, and office diastolic BP was significantly more reduced after AEX but not IHG exercise. Responses to training were not significantly different between both the exercise interventions. Eight weeks of home-based AEX results in significant reductions in both ambulatory BP and office BP in healthy adults, whereas IHG reduces only office BP.

      PubDate: 2018-04-16T01:54:13Z
      DOI: 10.1016/j.jash.2018.01.007
       
  • Risk Factors For Arterial Hypertension After Liver Transplantation
    • Authors: Cristina Di Stefano; Ester Vanni; Stefano Mirabella; Ramy Younes; Valentina Boano; Elena Mosso; Elisabetta Nada; Valeria Milazzo; Simona Maule; Renato Romagnoli; Mauro Salizzoni; Franco Veglio; Alberto Milan
      Abstract: Publication date: Available online 5 January 2018
      Source:Journal of the American Society of Hypertension
      Author(s): Cristina Di Stefano, Ester Vanni, Stefano Mirabella, Ramy Ibrahim Kamal Jouness, Valentina Boano, Elena Mosso, Elisabetta Nada, Valeria Milazzo, Simona Maule, Renato Romagnoli, Mauro Salizzoni, Franco Veglio, Alberto Milan
      Background Arterial hypertension represents a common complication of immunosuppressive therapy after liver transplantation (LT). The aim of the study is the evaluation of prevalence and risk factors associated with arterial hypertension after LT. Methods From a cohort of 323 cirrhotic patients who underwent LT from 2008 to 2012, 270 patients were retrospectively evaluated, while 53 (16.4%) deceased during the 4-years follow-up. Hypertension was defined as blood pressure ≥140/90 mmHg in at least two visits and/or the need of antihypertensive therapy. Results The prevalence of hypertension was 15% before LT and significantly increased up to 53% after LT (p<0.001). Mean follow-up was 43±19 months after LT. In overall normotensive subjects at baseline, 35.9% developed sustained hypertension after LT, while 15.2% developed a transient form of hypertension within the first month after LT, and then returned normotensive. The development of sustained hypertension after LT was related to mammalian target of rapamycin inhibitors (mTORi) treatment (OR 4.02, 95% CI 1.26-13.48, p=0.02), alcoholic cirrhosis before LT (OR 3.38, 95% CI 1.44-8.09, p=0.005), and new-onset hepatic steatosis after LT (OR 2.13, 95% CI 1.10-4.11, p=0.02). Patients with transient hypertension were more often affected from hepatitis C virus related cirrhosis (p=0.02). Tacrolimus, the etiology and severity of liver disease, and other immunosuppressive regimens were not related to the development of hypertension after LT. Conclusions In our cohort, the prevalence of arterial hypertension has increased up to 53% after LT and metabolic comorbidities and immunosuppressive treatment with mTORi are risk factors for the development of hypertension after LT in previously normotensive subjects.

      PubDate: 2018-01-09T18:55:57Z
      DOI: 10.1016/j.jash.2018.01.002
       
  • Hypertension in postmenopausal women: hemodynamic and therapeutic
           implications
    • Authors: Veronique Regnault; Patrick Lacolley; Michel E. Safar
      Abstract: Publication date: Available online 4 January 2018
      Source:Journal of the American Society of Hypertension
      Author(s): V. Regnault, P. Lacolley, M.E. Safar


      PubDate: 2018-01-09T18:55:57Z
      DOI: 10.1016/j.jash.2018.01.001
       
  • The Prevalence of Central Hypertension Defined by a Central Blood Pressure
           Type I Device and Its Association with Target Organ Damage in
           Community-Dwelling Elderly Chinese: The Northern Shanghai Study
    • Authors: Shikai Yu; Jing Xiong; Yuyan Lu; Chen Chi; Jiadela Teliewubai; Bin Bai; Hongwei Ji; Yiwu Zhou; Ximin Fan; Jacques Blacher; Jue Li; Yi Zhang; Yawei Xu
      Abstract: Publication date: Available online 3 January 2018
      Source:Journal of the American Society of Hypertension
      Author(s): Shikai Yu, Jing Xiong, Yuyan Lu, Chen Chi, Jiadela Teliewubai, Bin Bai, Hongwei Ji, Yiwu Zhou, Ximin Fan, Jacques Blacher, Jue Li, Yi Zhang, Yawei Xu
      We aimed to investigate the prevalence of central hypertension and its association with target organ damage (TOD). 1983 community-dwelling elderly Chinese were recruited for this analysis. Brachial and central blood pressure (BP) were measured by a oscillometric device and SphygmoCor (type I device), respectively. Brachial hypertension was defined by brachial systolic (SBP)/diastolic BP (DBP)≥140/90mmHg or using antihypertensive medications. Central hypertension was defined by central SBP/DBP≥130/90mmHg or using antihypertensive medications. TOD included left ventricular hypertrophy (LVH) and diastolic dysfunction (LVDD), carotid-femoral pulse wave velocity (CF-PWV) and urinary albumin-creatinine ratio (UACR). In this cohort, there were 563(28.4%) brachial and central consistent normotension (BCCN), 46(2.3%) isolated brachial hypertension (IBH), 27(1.4%) isolated central hypertension (ICH), and 1347(67.9%) brachial and central combined hypertension (BCCH). In ANOVA, BCCH showed significantly higher levels in all TOD than BCCN. In multiple logistic regression, all TOD were significantly associated with BCCH (LVH: adjusted OR[95%CI] =2.03[1.55, 2.68]; LVDD:2.29[1.53, 3.43]; CF-PWV>10m/s: 3.41[2.55, 4.58]; UACR>30mg/g: 1.97[1.58, 2.44]), rather than IBH or ICH. In conclusion, central hypertension was prevalent (69.3%) in this elderly cohort. BCCH was independently and significantly associated with cardiac, arterial and renal damage. This finding implies that both brachial and central BPs need to be considered for managing hypertension.

      PubDate: 2018-01-09T18:55:57Z
      DOI: 10.1016/j.jash.2017.12.013
       
  • Ambulatory Blood Pressure Variability within the First 24-Hour after
           Admission and Outcomes of Acute Ischemic Stroke
    • Authors: Yu Zhang; Hong Wang; Ke Xu; Ping Wang; Xin-Yan Li; Jing-Bo Zhao; Ying Tang
      Abstract: Publication date: Available online 3 January 2018
      Source:Journal of the American Society of Hypertension
      Author(s): Yu Zhang, Hong Wang, Ke Xu, Ping Wang, Xin-Yan Li, Jing-Bo Zhao, Ying Tang
      Our purpose was to evaluate the value of blood pressure variability within the first 24-hour after admission in predicting outcomes of patients with acute ischemic stroke. A greater variability in systolic blood pressure (adjusted odds ratio [OR] = 1.801, 95% confidence interval [CI] = 1.167-2.779) was associated with poor discharge outcome, especially for non-diabetics (adjusted OR =1.948, 95% CI = 1.184-3.205) and cardioembolism-related patients with acute ischemic stroke (OR = 7.650, 95% CI = 1.370-42.713). However, this correlation was not observed with a long-term (3-month or 6-month) outcome in patients with acute ischemic stroke. There was no association between diastolic blood pressure variability within the first 24-hour after admission and outcome. In conclusion, systolic blood pressure variability within the first 24-hour after admission is a critical predictor for short-term outcome of patients with acute ischemic stroke.
      Graphical abstract image

      PubDate: 2018-01-09T18:55:57Z
      DOI: 10.1016/j.jash.2017.12.012
       
  • Severe Obstructive Sleep Apnea in Children with Elevated Blood Pressure
    • Authors: Jane Hinkle; Heidi V. Connolly; Heather R. Adams; Marc B. Lande
      Abstract: Publication date: Available online 3 January 2018
      Source:Journal of the American Society of Hypertension
      Author(s): Jane Hinkle, Heidi V. Connolly, Heather R. Adams, Marc B. Lande
      The objective was to determine the prevalence of habitual snoring and obstructive sleep apnea (OSA) in a cohort of children referred for elevated BP, and to determine the association between OSA and blood pressure elevation, learning difficulties, and behavioral problems. We performed a retrospective review of 446 consecutive new patients referred for elevated BP. One hundred four (23%) had habitual snoring. Patients with habitual snoring were more likely to be obese (86.5 vs 55.6%, p < 0.001) and to have Medicaid insurance (52.4 vs 36%, p = 0.004). Seventy-four patients had polysomnography, of which 57 (77%) had OSA; 21 (37%) had severe OSA. Severe OSA was associated with higher office systolic BP index after adjusting for body mass index, age, sex, and SES (β = 0.07, p = 0.014). Fifty-two percent of patients with severe OSA had office systolic BP in the stage 2 hypertension range. Children with habitual snoring or OSA were not at increased risk of receiving school services for a learning disability or receiving medications for inattention or mood problems. In summary, habitual snoring is common in children referred for elevated BP, and those with severe OSA are at higher risk of significantly increased BP.

      PubDate: 2018-01-09T18:55:57Z
      DOI: 10.1016/j.jash.2017.12.010
       
  • Association between hypertension in adolescents and the health risk
           factors of their parents: An epidemiological family study
    • Authors: Diego Giulliano Destro Christofaro; Arthur E. Mesas; Raphael M. Ritti Dias; Rômulo A. Fernandes; Bruna T.C. Saraiva; Mariana R. Palma; Diego A.S. Silva; Selma M. de Andrade
      Abstract: Publication date: Available online 2 January 2018
      Source:Journal of the American Society of Hypertension
      Author(s): Diego G.D. Christofaro, Arthur E. Mesas, Raphael M. Ritti Dias, Rômulo A. Fernandes, Bruna T.C. Saraiva, Mariana R. Palma, Diego A.S. Silva, Selma M. de Andrade
      Hypertension in adolescence may be a predictor of cardiovascular problems in adulthood. Therefore, verification of the factors associated with this condition in adolescence is important. The aim of this study was to analyze the relationship between hypertension in adolescents with hypertension and the sociodemographic characteristics and lifestyle of their parents. This study was conducted on 1,231 adolescents, 1,202 mothers and 871 fathers. The blood pressure of the adolescents was measured with an oscillometric device. Details of parental hypertension, sociodemographic characteristics and lifestyle were obtained by self-report. The prevalence of hypertension was higher among adolescents with older fathers and older mothers, with both parents reporting hypertension and with mothers who were overweight. In multivariable analysis, adolescents with older mothers (OR = 2.36 [95% CI=1.12-4.98]), hypertensive mothers (OR= 2.22 [95% CI=1.26-3.89]) and hypertensive fathers (OR= 1.70 [95% CI=1.03-2.81]) were more likely to have hypertension. In the analysis that considered clusters of health risk factors, higher risks of hypertension were observed in adolescents whose mothers had four or more aggregated risk factors (OR = 2.53 [95% CI=1.11-5.74]). In conclusion, there was a relationship between hypertension in adolescents and hypertension in their parents. However, an association between hypertension in adolescents and parental age and clusters of health risk factors was only observed for their mothers.

      PubDate: 2018-01-09T18:55:57Z
      DOI: 10.1016/j.jash.2017.12.011
       
  • Common Variants at Somatostatin Are Significantly Associated with
           Hypertension Incidence in Smoking and Drinking Populations
    • Authors: Hui Zhu; Lijun Zhu; Zhengmei Fang; Song Yang; Yanchun Chen; Yuelong Jin; Xianghai Zhao; Chong Shen; Yingshui Yao
      Abstract: Publication date: Available online 28 December 2017
      Source:Journal of the American Society of Hypertension
      Author(s): Hui Zhu, Lijun Zhu, Zhengmei Fang, Song Yang, Yanchun Chen, Yuelong Jin, Xianghai Zhao, Chong Shen, Yingshui Yao
      Somatostatin (SST) and growth hormone releasing hormone (GHRH) were involved in the development of hypertension. This study aimed to evaluate whether SST and GHRH contribute to genetic susceptibility to hypertension. A case-control study consisted of 2012 hypertensive cases and 2210 matched controls, and three tagging single nucleotide polymorphisms (tagSNPs) were genotyped. The association of these SNPs with hypertension and ischemic stroke were further evaluated among 4098 participants in a follow-up study. Hazard ratio (HR) and 95% confidence interval (CI) was estimated by Cox's proportional hazard regression. Follow-up study indicated that in smoking population, variants at SST presented significant association with hypertension incidence, and the adjusted HR of rs3755792 (GA+AA vs. GG) was 0.634 (P=0.037), and the adjusted HR of rs7624906 (TC+CC vs. TT) was 1.803 (P=0.005). In drinking population, rs3755792 at SST was associated with hypertension incidence, and the adjusted HR was 0.580 (P=0.009). Moreover, rs6032470 at GHRH had a statistical association with ischemic stroke incidence in smoking population, the adjusted HR of additive model was 1.625 (P=0.049). These results suggested that SST and GHRH harbor genetic susceptible loci with incident hypertension and ischemic stroke, smoking and drinking might modify the genetic effect.

      PubDate: 2018-01-09T18:55:57Z
      DOI: 10.1016/j.jash.2017.12.009
       
  • Are there cardiometabolic benefits of low-intensity physical activity in
           at-risk adults'
    • Authors: Brent Egan
      Abstract: Publication date: Available online 28 December 2017
      Source:Journal of the American Society of Hypertension
      Author(s): Brent M. Egan


      PubDate: 2018-01-09T18:55:57Z
       
  • Effects of orlistat on blood pressure: a systematic review and
           meta-analysis of 27 randomized controlled clinical trials
    • Authors: Amirhossein Sahebkar; Luis E. Simental-Mendía; Petri T. Kovanen; Claudio Pedone; Mario Simental-Mendía; Arrigo F.G. Cicero
      Abstract: Publication date: Available online 14 December 2017
      Source:Journal of the American Society of Hypertension
      Author(s): Amirhossein Sahebkar, Luis E. Simental-Mendía, Petri T. Kovanen, Claudio Pedone, Mario Simental-Mendía, Arrigo F.G. Cicero
      Obesity and high blood pressure (BP) are strongly related and weight loss is mightily associated with a significant BP decrease. The aim of the present meta-analysis was to evaluate and quantify the BP decrease associated with orlistat use in randomized controlled trials. The search included PubMed-Medline, Scopus, Web of Science and Google Scholar databases by up to June 05, 2017, to identify randomized controlled trials investigating the impact of orlistat on blood pressure. Quantitative data synthesis was performed using a random-effects model, with weighed mean difference and 95% confidence interval as summary statistics. Meta-regression and leave-one-out sensitivity analyses were performed to assess the modifiers of treatment response. Our meta-analysis included 27 randomized controlled clinical trials which comprehended overall 8150 subjects (4419 in the orlistat group and 3731 in the control one). We observed a statistically significant decreasing effect of orlistat on both systolic BP (−1.15 mmHg [−2.11, −0.19]) and diastolic BP (−1.07 mmHg [−1.69, −0.45]), regardless of its dosage. Significant associations were found between changes in systolic BP and diastolic BP with treatment duration but not with corresponding baseline BP values. In conclusion, Orlistat use contributes weight loss associated decrease in BP in overweight and obese subjects.

      PubDate: 2017-12-27T09:06:34Z
      DOI: 10.1016/j.jash.2017.12.002
       
  • Latest guidelines for hypertension: adopt and adapt
    • Authors: C. Venkata S. Ram
      Abstract: Publication date: Available online 14 November 2017
      Source:Journal of the American Society of Hypertension
      Author(s): C. Venkata S. Ram


      PubDate: 2017-11-16T18:12:59Z
      DOI: 10.1016/j.jash.2017.11.002
       
  • Occupational noise exposure and hypertension: the Dongfeng-Tongji Cohort
           Study
    • Authors: Dongming Wang; Min Zhou; Wenzhen Li; Weijia Kong; Zhichao Wang; Yanjun Guo; Xiaomin Zhang; Meian He; Huan Guo; Weihong Chen
      Abstract: Publication date: Available online 13 November 2017
      Source:Journal of the American Society of Hypertension
      Author(s): Dongming Wang, Min Zhou, Wenzhen Li, Weijia Kong, Zhichao Wang, Yanjun Guo, Xiaomin Zhang, Meian He, Huan Guo, Weihong Chen
      The association between occupational noise exposure and hypertension is unclear. We aimed to explore the association in a Chinese population and to summarize our findings with previous published articles. The cross-sectional study included 22450 participants from Dongfeng-tongji Cohort Study. In a subsample of 10636 subjects, we assessed the association between hearing loss and hypertension. For the meta-analysis, we searched Pubmed and Embase until April 2017, and the pooled odds ratio was combined by using a random-effect model. Compared with participants without occupational noise exposure, the risk of hypertension was significantly higher for noise exposure duration ≥20 (OR=1.09, 95%CI=1.00-1.18). In the sex-specific analysis, the association was only significantly pronounced in males (OR=1.16, 95%CI=1.03-1.31), but not in females (OR=1.01, 95%CI=0.88-1.14). In the subsample analyses, hearing loss, which was an indicator for exposure to loud noise, was associated with a higher risk of hypertension, especially for participants who were bilateral hearing loss (OR=1.39, 95%CI=1.24-1.54). In the meta-analysis, the pooled OR for the association between occupational noise exposure and hypertension was 1.25 (95%CI=1.10-1.42). On the basis of an indicator for exposure to occupational noise, the cross-sectional study and meta-analysis identified occupational noise exposure as a potential risk factor for increased hypertension risk.

      PubDate: 2017-11-16T18:12:59Z
      DOI: 10.1016/j.jash.2017.11.001
       
 
 
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