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  Subjects -> ALTERNATIVE MEDICINE (Total: 111 journals)
Showing 1 - 15 of 15 Journals sorted alphabetically
Acupuncture & Electro-Therapeutics Research     Full-text available via subscription   (Followers: 8)
Acupuncture and Related Therapies     Hybrid Journal   (Followers: 10)
Acupuncture in Medicine     Hybrid Journal   (Followers: 19)
Advanced Herbal Medicine     Open Access   (Followers: 8)
Advances in Traditional Medicine     Hybrid Journal   (Followers: 8)
African Journal of Traditional, Complementary and Alternative Medicines     Open Access   (Followers: 7)
Akupunktur & Aurikulomedizin     Full-text available via subscription   (Followers: 1)
Allgemeine Homöopathische Zeitung     Hybrid Journal   (Followers: 3)
Alternative & Integrative Medicine     Open Access   (Followers: 16)
Alternative and Complementary Therapies     Hybrid Journal   (Followers: 22)
Alternative Medicine     Full-text available via subscription   (Followers: 4)
Alternative Medicine Studies     Open Access   (Followers: 14)
Anales de Hidrología Médica     Open Access   (Followers: 2)
Ancient Science of Life     Open Access   (Followers: 6)
Arabian Journal of Medicinal and Aromatic Plants     Open Access   (Followers: 4)
Arteterapia. Papeles de arteterapia y educación artística para la inclusión social     Open Access   (Followers: 5)
Asian Journal of Plant Pathology     Open Access   (Followers: 4)
Australian Journal of Acupuncture and Chinese Medicine     Full-text available via subscription   (Followers: 4)
Australian Journal of Herbal Medicine     Full-text available via subscription   (Followers: 5)
Australian Journal of Music Therapy     Full-text available via subscription   (Followers: 11)
Avicenna Journal of Phytomedicine     Open Access   (Followers: 1)
AYU : An international quarterly journal of research in Ayurveda     Open Access   (Followers: 6)
BMC Complementary and Alternative Medicine     Open Access   (Followers: 23)
Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas     Open Access   (Followers: 2)
Botanics : Targets and Therapy     Open Access   (Followers: 6)
Cadernos de Naturologia e Terapias Complementares     Open Access   (Followers: 1)
Chinese Herbal Medicines     Full-text available via subscription   (Followers: 1)
Chinese Medicine     Open Access   (Followers: 5)
Cognitive Neuroscience     Hybrid Journal   (Followers: 31)
Complementary Therapies in Clinical Practice     Hybrid Journal   (Followers: 23)
Complementary Therapies in Medicine     Hybrid Journal   (Followers: 19)
Current Traditional Medicine     Hybrid Journal   (Followers: 5)
Deutsche Heilpraktiker-Zeitschrift     Hybrid Journal   (Followers: 3)
Deutsche Zeitschrift für Akupunktur     Full-text available via subscription   (Followers: 2)
Erfahrungsheilkunde     Hybrid Journal   (Followers: 1)
European Journal of Medicinal Plants     Open Access  
Evidence-based Complementary and Alternative Medicine     Open Access   (Followers: 30)
Experimental and Therapeutic Medicine     Full-text available via subscription   (Followers: 1)
Fitoterapia     Hybrid Journal   (Followers: 9)
Focus on Alternative and Complementary Therapies     Hybrid Journal   (Followers: 12)
Global Journal of Integrated Chinese Medicine and Western Medicine     Open Access   (Followers: 1)
Global Journal of Traditional Medicine     Open Access   (Followers: 2)
Herba Polonica     Open Access   (Followers: 1)
Herbal Medicines Journal     Open Access   (Followers: 1)
Indian Journal of Research in Homoeopathy     Open Access   (Followers: 2)
Indian Journal of Traditional Knowledge (IJTK)     Open Access   (Followers: 2)
Innovare Journal of Ayurvedic Sciences     Open Access   (Followers: 10)
Intas Polivet     Full-text available via subscription   (Followers: 5)
Integrative Medicine Research     Open Access   (Followers: 3)
International Journal of Health and Medicine     Open Access   (Followers: 1)
International Journal of High Dilution Research     Open Access  
International Journal of Qualitative Studies on Health and Well-Being     Open Access   (Followers: 22)
International Journal of Yoga     Open Access   (Followers: 17)
International Journal of Yoga : Philosophy, Psychology and Parapsychology     Open Access   (Followers: 7)
Ipnosi     Full-text available via subscription  
Journal of Acupuncture and Herbs     Open Access   (Followers: 3)
Journal of Acupuncture and Meridian Studies     Open Access   (Followers: 1)
Journal of Acupuncture and Tuina Science     Hybrid Journal   (Followers: 4)
Journal of Alternative and Complementary Medicine     Hybrid Journal   (Followers: 17)
Journal of Applied Arts and Health     Hybrid Journal   (Followers: 1)
Journal of Applied Research on Medicinal and Aromatic Plants     Hybrid Journal   (Followers: 1)
Journal of Asian Natural Products Research     Hybrid Journal   (Followers: 5)
Journal of Ayurveda and Integrative Medicine     Open Access   (Followers: 7)
Journal of AYUSH :- Ayurveda, Yoga, Unani, Siddha and Homeopathy     Full-text available via subscription   (Followers: 10)
Journal of Bodywork and Movement Therapies     Hybrid Journal   (Followers: 18)
Journal of Complementary and Alternative Medical Research     Open Access   (Followers: 1)
Journal of Complementary and Integrative Medicine     Hybrid Journal   (Followers: 12)
Journal of Dance Medicine & Science     Full-text available via subscription   (Followers: 14)
Journal of Evidence-Based Integrative Medicine     Open Access   (Followers: 18)
Journal of Fasting and Health     Open Access   (Followers: 1)
Journal of Ginseng Research     Open Access  
Journal of Health Science and Alternative Medicine     Open Access   (Followers: 1)
Journal of Health Sciences Scholarship     Open Access  
Journal of Herbal Drugs (An International Journal on Medicinal Herbs)     Open Access   (Followers: 1)
Journal of Herbal Medicine     Hybrid Journal   (Followers: 2)
Journal of Herbal Science     Full-text available via subscription   (Followers: 6)
Journal of Integrative Medicine     Full-text available via subscription   (Followers: 4)
Journal of Integrative Medicine & Therapy     Open Access   (Followers: 2)
Journal of Manual & Manipulative Therapy     Hybrid Journal   (Followers: 17)
Journal of Medicinal Plants for Economic Development     Open Access  
Journal of Medicinally Active Plants     Open Access   (Followers: 2)
Journal of Natural Remedies     Open Access   (Followers: 3)
Journal of Nutraceuticals and Herbal Medicine     Open Access   (Followers: 4)
Journal of Palliative Medicine     Hybrid Journal   (Followers: 48)
Journal of the Australian Traditional-Medicine Society     Full-text available via subscription   (Followers: 1)
Journal of Traditional and Complementary Medicine     Open Access   (Followers: 4)
Journal of Traditional Chinese Medical Sciences     Open Access   (Followers: 1)
Journal of Yoga & Physical Therapy     Open Access   (Followers: 9)
Lekovite Sirovine     Open Access  
Médecine Palliative : Soins de Support - Accompagnement - Éthique     Full-text available via subscription   (Followers: 2)
Medical Acupuncture     Hybrid Journal   (Followers: 6)
Medicines     Open Access   (Followers: 1)
Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi ve Folklorik Tıp Dergisi     Open Access  
Muller Journal of Medical Sciences and Research     Open Access  
Natural solutions     Full-text available via subscription  
Natural Volatiles & Essential Oils     Open Access   (Followers: 1)
Nigerian Journal of Natural Products and Medicine     Full-text available via subscription  
OA Alternative Medicine     Open Access   (Followers: 1)
Oriental Pharmacy and Experimental Medicine     Partially Free   (Followers: 3)
Research Journal of Medicinal Plant     Open Access   (Followers: 2)
Research Journal of Pharmacognosy     Open Access  
Revista Brasileira de Plantas Medicinais     Open Access   (Followers: 1)
Revista Internacional de Acupuntura     Full-text available via subscription  
South African Journal of Plant and Soil     Hybrid Journal   (Followers: 1)
Synfacts     Hybrid Journal   (Followers: 7)
Traditional & Kampo Medicine     Full-text available via subscription  
Traditional Medicine Journal     Open Access   (Followers: 2)
World Journal of Acupuncture - Moxibustion     Full-text available via subscription   (Followers: 1)
World Journal of Traditional Chinese Medicine     Open Access   (Followers: 1)
Yoga Mimamsa     Open Access   (Followers: 2)
Zeitschrift für Orthomolekulare Medizin     Hybrid Journal   (Followers: 2)

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Journal of Medicinal Plants for Economic Development
Number of Followers: 0  

  This is an Open Access Journal Open Access journal
ISSN (Print) 2519-559X - ISSN (Online) 2616-4809
Published by AOSIS Publishing Homepage  [34 journals]
  • Effect of lupeol from Vernonia glaberrima (Asteraceae) on pain and
           inflammation

    • Authors: Amina J. Yusuf, Musa I. Abdullahi, Aisha M. Umar, Fatima Musa
      First page: 5
      Abstract: Background: Steroids have been reported to possess analgesic and anti-inflammatory activities, and Vernonia glaberrima also possesses analgesic and anti-inflammatory properties.Aim: The aim of the study was to evaluate the effect of lupeol isolated from the n-hexane soluble fraction of the methanol leaf extract of V. glaberrima on pain and inflammation.Method: Lupeol was re-isolated from the leaf of V. glaberrima by using chromatographic procedures; it was subjected to analgesic and anti-inflammatory studies by using acetic acid-induced writhing test in mice and formalin-induced pain and inflammation in rats, respectively. The intraperitoneal lethal dose (LD50) of lupeol was determined by using Lorke’s method.Results: The results of the study showed that lupeol significantly (p < 0.05) decreased writhing response at doses 12.5 mg/kg, 25.0 mg/kg and 50.0 mg/kg corresponding to percentage inhibition of 83.60%, 83.63% and 80.02%, respectively. This was higher than piroxicam, the standard drug (73.8%), at 10 mg/kg. The compound was also able to significantly (p < 0.05) reduce nociceptive response in both phases of the formalin test, and there was a remarkable reduction of oedema by the compound at the second, third and fourth hours. The median LD50 of the compound was estimated to be greater than 5000 mg/kg.Conclusion: The findings of this study indicated that lupeol from the leaf of V. glaberrima has good analgesic and anti-inflammatory activity that validates the ethnomedicinal use of the plant in the treatment of pain and inflammatory conditions.
      PubDate: 2020-09-15
      DOI: 10.4102/jomped.v4i1.84
      Issue No: Vol. 4, No. 1 (2020)
       
  • Comparative in-vitro anticancer and brine shrimp cytotoxic activities of
           Mezoneuron benthamianum Baill.

    • Authors: Paul M. Osamudiamen, Olapeju O. Aiyelaagbe, Shagun Vaid, Payare L. Sangwan, Abiodun B. Ogbesejana, Ajit K. Saxena
      First page: 5
      Abstract: Background: Cancer is one of the leading causes of global mortality and recently, it has been established that there is a link between periodontal disease and various types of cancer. In Nigeria, chewing sticks are used especially in the rural areas to maintain oral hygiene and to prevent periodontal disease. Mezoneuron benthamianum is a plant that is used locally as a chewing stick in the southwest of Nigeria, but there has been no report on its anticancer properties.Aim: This study is aimed at determining the anticancer activity using sulforhodamine B (SRB) assay and brine shrimp cytotoxic activity of the extracts of M. benthamianum.Setting: The roots of M. benthamianum were obtained from Ibadan, Oyo State, Nigeria, and were identified and authenticated at the University of Ibadan Herbarium.Methods: The plant sample was subsequently dried, pulverised and extracted with hexane, dichloromethane, ethyl acetate and methanol to give the different extracts which were tested against four cell lines (Lung A549, Lung NCI-H322, Breast T47D and Prostate PC-3) using the SRB assay and were also evaluated against brine shrimp nauplii.Results: The results of the study showed that the different extracts of M. benthamianum had selective and consistent cytotoxic activity against the Lung (A549), Lung (NCI-H322) and Breast (T47D) cell lines, having a percentage growth inhibition ranging from 36% to 63%. The hexane and dichloromethane extracts also gave LC50 values of 99.96 and 29.29 against brine shrimp cytotoxic activity.Conclusion: These results justify the use of M. benthamianum in folkloric medicine.
      PubDate: 2020-06-25
      DOI: 10.4102/jomped.v4i1.73
      Issue No: Vol. 4, No. 1 (2020)
       
  • Suppressive and curative antiplasmodial properties of Nauclea latifolia
           root extract and fractions against erythrocytic stage of mice-infective
           chloroquine-sensitive Plasmodium berghei NK-65

    • Authors: Chinwe S. Alaribe, Akolade R. Oladipupo, Miracle O. Nani, Innocent N. Ijeoma, Bolutiwi D. Olanipekun, Herbert A.B. Coker
      First page: 6
      Abstract: Background: Malaria remains a devastating disease, particularly in the tropics, where it is the highest killer of pregnant women and children under the age of 5 years. Significant efforts and resources have been vested in malaria control and eradication programmes, but the unavailability of malaria vaccine and the emergence of resistance of malaria parasite to existing antimalarial drugs have continued to hamper attempts at controlling or eradicating the disease. This warrants the development of new antimalarial drugs. Nauclea latifolia root is widely applied for malaria treatment in Nigeria.Aim: This study investigated the antimalarial property of N. latifolia roots.Setting: N. latifolia roots were collected from Ikwuano, Umuahia, Abia State, Nigeria.Methods: To extract the bioactive constituents, an aqueous infusion of the plant was prepared and fractionated by solvent-solvent extraction with n-hexane, ethyl acetate and butanol, respectively. Antimalarial property was evaluated using suppressive and curative assays in mice infected with chloroquine-sensitive Plasmodium berghei NK-65 strain.Results: The extract and fractions produced significant suppressive and curative antiplasmodial activities (p < 0.05). The aqueous extract and n-hexane and butanol fractions gave 85.22%, 84.52% and 91.32% chemosuppression, respectively, which were comparable to that of chloroquine used as positive control. The extract and fractions gave considerable curative effects in the range 52.23% – 77.00%.Conclusion: These findings indicate that N. latifolia roots possess antimalarial property and reflect its ethnomedicinal use for malaria treatment. Thus, N. latifolia roots may be exploited for development of herbal formulations and isolation of novel bioactive compounds for malaria treatment.
      PubDate: 2020-06-30
      DOI: 10.4102/jomped.v4i1.72
      Issue No: Vol. 4, No. 1 (2020)
       
  • Antidiarrhoeal activity of fractions of aqueous extract of Mangifera
           indica L. leaves in castor oil-induced diarrhoeal female Wistar rats

    • Authors: Saoban S. Salimon, Musa T. Yakubu
      First page: 7
      Abstract: Background: The aqueous extract of Mangifera indica leaves (AEMIL) has been substantiated for its antidiarrhoeal activity without information on the antidiarrhoeal-rich solvent fraction.Aim: This study evaluated the antidiarrhoeal activity of solvent–solvent fractions from M. indica leaves in female Wistar rats.Setting: This is laboratory animal-based phytopharmacological investigation conducted at the University of Ilorin.Methods: Aqueous extract of M. indica leaves was successfully fractionated to give ethyl acetate fraction (EAF), n-butanol fraction (NBF) and aqueous residual fraction (ARF). The fractions at 25, 50 and 100 mg/kg body weight (bw) were screened for antidiarrhoeal activity. The antidiarrhoeal index (ADI) was also computed.Results: Ethyl acetate fraction, NBF and ARF significantly (p < 0.05) extended the onset of diarrhoea, reduced fecal parameters (number, weight and water content of feaces and number of diarrhoeal feaces), masses and volumes of intestinal fluid, distance covered by charcoal meal, peristaltic index and its inhibition, with ARF exhibiting the most pronounced effects. The ADI at 25 and 100 mg/kg bw (equivalent doses of 14.09 and 56.3 mg/kg bw, respectively) of ARF which were 55.19 and 49.87, respectively were similar to 48.50 produced by loperamide/atropine sulphate. The ADI of 32.36 and 10.18 for 100 mg/kg bw each (equivalent of 26.41 and 17.24 mg/kg bw) of EAF and NBF respectively, were lower than that of loperamide/atropine sulphate (48.50).Conclusion: Of all the fractions, the 25 mg/kg bw of ARF produced the most profound antidiarrhoeal activity via anti-motility and anti-secretory mechanisms.
      PubDate: 2020-09-14
      DOI: 10.4102/jomped.v4i1.88
      Issue No: Vol. 4, No. 1 (2020)
       
  • Antimicrobial activity of Ficus exasperata (Vahl) leaf extract in clinical
           isolates and its development into herbal tablet dosage form

    • Authors: Tolulope O. Ajala, Ayobami J. Olusola, Oluwatoyin A. Odeku
      First page: 8
      Abstract: Background: Ficus exasperata (Vahl) from the family Moraceae is a herb of ethnobotanical importance with antimicrobial properties. The past studies have been on the phytochemistry and pharmacological activities of the plant, but there is a need to formulate this valuable herb into tablet dosage form to offer standardisation.Aim: The aim of this study was to assess the antimicrobial activity of F. exasperata leaf extract (extract) and formulate it into herbal tablet dosage form.Setting: The experiments were performed at the laboratories of the Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria.Methods: The extract was obtained by maceration and assessed for antimicrobial activity using agar cup diffusion method. Tablets were prepared by direct compression using Avicel®, Lactose and Emcompress® at a drug–diluent ratio of 1:4 and 1:9. The flow properties of the powder mixtures were determined using compressibility index, Hausner’s ratio, angle of repose and density measurements. The mechanical properties of the tablets were assessed using crushing strength (CS), friability (FR) and the crushing strength–friability ratio (CSFR) and release properties with disintegration times (DT), disintegration efficiency ratio and dissolution times. Analyses were carried out using two-way analysis of variance on Prism 5.0.Results: The results showed that the extract had concentration-dependent antimicrobial activity. The flow properties of the powder mixtures were in the rank order of Avicel® > Lactose > Emcompress®. Tablet CS and CSFR increased, whilst FR decreased with increase in compression force and diluent concentration. All tablets passed the DT test. The ranking of dissolution times was Avicel® < Lactose < Emcompress® < no diluent.Conclusion: Ficus exasperata extract demonstrated antimicrobial properties dependent on type of organism and extract concentration. The herbal tablets have acceptable mechanical and release parameters, which varied with diluent type, drug–diluent ratio and compression pressure.
      PubDate: 2020-10-19
      DOI: 10.4102/jomped.v4i1.95
      Issue No: Vol. 4, No. 1 (2020)
       
  • Chemical composition, cytotoxicity and anti-mycobacterium activities of
           Clausena anisata essential oils

    • Authors: Ibraheem O. Lawal
      First page: 8
      Abstract: Background: Clausena anisata (Willd) Hook has demonstrated several medicinal properties against certain bacterial infections, including tuberculosis. However, scientific validation is imperative to verify its folkloric usage against tuberculosis.Aim: This study aimed at determining the chemical composition, toxicity and anti-tubercular potentials of the oils extracted from this plant.Setting: Plant material collection, essential oils extraction and antimycobacterial activity were performed at the University of Fort Hare, Alice, South Africa. This article and selected technical aspect was constructed at the Biomedicinal Research Centre, Forestry Research Institute of Nigeria.Methods: Comparative chemical composition of hydrodistilled (HD) and solvent-free microwaved essential (SFME) oils from C. anisata was analysed by gas chromatography coupled with mass spectroscopy (GC–MS). In vitro minimum inhibitory concentration (MIC) assay was also carried out on the oils against a strain of Mycobacterium tuberculosis. The cytotoxicity assay of the oils was also assessed by using human dermal fibroplast (MRHF) cell lines.Results: Gas chromatography–mass spectroscopy analysis of the essential oils revealed 51 distinct compounds with methyl eugenol and estragole in abundance. The IC50 of volatile oils from SFME and HD methods against the MRHF cell line were 1 216 µg/mL and 383 µg/mL, respectively. On the other hand, both oils and ethambutol (standard drug) showed no activity against the strain of M. tuberculosis, but rifampicin supressed the growth of the organism at 0.25 µg/mL.Conclusion: This study showed that C. anisata is safe for consumption, and further studies of combinative potent but non-toxic oils engaging hydrodistillation method are strongly recommended for enhanced effect against M. tuberculosis.
      PubDate: 2020-09-29
      DOI: 10.4102/jomped.v4i1.90
      Issue No: Vol. 4, No. 1 (2020)
       
  • Anti-diarrhoeal activity of aqueous extract of Cochlospermum planchonii
           (Hook Fx. Planch) leaves in female Wistar rats

    • Authors: Musa T. Yakubu, Omowunmi D. Amoniyan, Mariam O. Mohammed, Christine I. Assin, Jemilat O. Abubakar, Saoban S. Salimon, Sikemi A. Omar
      First page: 8
      Abstract: Background: The folkloric use of Cochlospermum planchonii is yet to be substantiated with scientific evidence.Aim: The aqueous extract of C. planchonii leaves was evaluated for anti-diarrhoeal activity at 125, 250 and 500 mg/kg body weight in female Wistar rats.Setting: This research is a phytopharmacological investigation.Methods: Animal were monitored for indicators of diarrhoea in the 3 models after treatments.Results: An aqueous extract of C. planchonii leaves contained 10 secondary metabolites, with alkaloids (16.05 mg/L) occurring the most, whilst quinones (0.7 mg/L) were the least. The extract significantly (p < 0.05) prolonged the onset time of diarrhoea, decreased water content, fresh weight and total number of wet faeces in a dose-dependent manner, and increased the percentage inhibition of defecation. The extract produced dose-specific changes on intestinal superoxide dismutase, glucose and reduced glutathione whereas the levels of intestinal Na+/K+-ATPase, alkaline phosphatase, catalase, nitric oxide were significantly (p < 0.05) increased in the castor oil-induced diarrhoeal model. The masses and volumes of intestinal fluid decreased significantly (p < 0.05) whereas the inhibition of intestinal fluid content increased like those of atropine-treated diarrhoeal rats in the enteropooling model. The extract dose-dependently decreased the distance travelled by the charcoal meal and increased the intestinal nitric oxide and acetylcholinesterase in the charcoal meal transit model.Conclusion: The aqueous extract of C. planchonii leaves exhibited anti-diarrhoeal activity via anti-motility and anti-secretory means. The flavonoids, alkaloids, tannins, phenolics and saponins might have acted to enhance the activities of Na+/K+-ATPase, antioxidant enzymes, intestinal glucose levels and the neurotransmitters.
      PubDate: 2020-06-30
      DOI: 10.4102/jomped.v4i1.81
      Issue No: Vol. 4, No. 1 (2020)
       
  • Anti-snake venom and analgesic activities of extracts and betulinic and
           oleanolic acids isolated from Parinari curatellifolia

    • Authors: Emmanuel Mshelia Halilu, Natasha October, Chinenye J. Ugwah-Oguejiofor, Amina Yusuf Jega, Mathias Sylvester Nefai
      First page: 8
      Abstract: Background: Parinari curatellifolia is used in Nigeria by traditional medicine practitioners (TMPs) for the treatment of snakebite and other conditions.Aim: This study is aimed at evaluating the anti-snake venom (ASV) and analgesic activities of n-hexane, ethyl acetate and methanol extracts as well as that of betulinic and oleanolic acids.Setting: The extracts and the isolates were subjected to acute toxicity studies, anti-snake venom and analgesic activities.Methods: Acute toxicity studies for the extracts were performed according to Lorke’s method whilst that of betulinic and oleanolic acids were performed according to Organization for Economic Co-operation Development 425 at the limit dose of 2000 mg/kg in mice. The ASV activity of the extracts and the betulinic and oleanolic acids were screened against Naja nigricollis venom phospholipases using the phospholipase-A2 acidimetric assay. The analgesic activity of ethyl acetate extract (35 mg/kg, 70 mg/kg, 140 mg/kg), betulinic acid (1 mg/kg, 5 mg/kg, 10 mg/kg) and oleanolic acid (1 mg/kg, 5 mg/kg, 10 mg/kg) were evaluated using acetic acid-induced abdominal constrictions in mice.Results: The LD50 of the methanol and ethyl acetate extracts were 113 mg/kg and 471.17 mg/kg, respectively, whilst that of the betulinic and oleanolic acids were greater than 2000 mg/kg. In the ASV study, the extracts inhibited the hydrolytic action of phospholipases with a percentage inhibition of 24.1% (n-hexane), 29.3% (ethyl acetate) and 20.7% (methanol), whilst the ASV (standard) caused 72.9% inhibition. On the other hand, the betulinic and oleanolic acids inhibited the hydrolytic action of phospholipases with a percentage inhibition of 35.6% and 31.4% respectively. For the analgesic evaluation, the ethyl acetate extract exhibited analgesic activity by producing a significant (p < 0.05) reduction in the number of writhes (7.75 ± 1.20, 11.82 ± 3.10 and 14.98 ± 2.72) at 140 mg/kg, 70 mg/kg and 35 mg/kg, respectively. Betulinic acid at 10 mg/kg, 5 mg/kg and 1 mg/kg showed a mean number of writhes of 3.40 ± 0.8, 4.20 ± 1.4 and 5.60 ± 2.1, respectively. Oleanolic acid at 10 mg/kg and 5 mg/kg also showed 7.50 ± 2.6 and 6.40 ± 1.8 mean number of writhes.Conclusion: This study has validated scientifically why P. curatellifolia is used traditionally in the treatment of snakebite, as the ethyl acetate extract and the isolated compounds moderately inhibited the hydrolytic action of phospholipase-A2. Also, betulinic and oleanolic acids exhibited analgesic activity in acetic acid-induced writhing in mice.
      PubDate: 2020-06-29
      DOI: 10.4102/jomped.v4i1.77
      Issue No: Vol. 4, No. 1 (2020)
       
  • Structure and conduct of medicinal plants supply chain in Kwara State

    • Authors: Matthew O. Adewumi, Grace O. Akinsola, Olaide O. Olawoye
      First page: 9
      Abstract: Background: There has been paucity of data on medicinal plants supply chain in Kwara State. The development of medicinal plants supply chain is a vital tool to ensure affordability and accessibility of medicinal plants to the herbal medicine producers.Aim: This study examined the supply chain, structure, conduct and performance of medicinal plants in Kwara State.Setting: Respondents data were drawn from the various sections of the herbal plants supply chain in Kwara State.Methods: Descriptive statistics, concentration ratio, coefficient of variation, cost and returns analysis and Likert type scale were used for data analysis. Data collection was through interview schedule and structured questionnaire. Purposive and snowball sampling techniques were used to draw a sample of 128 respondents.Results: The results revealed that the supply chain upstream was informal, and the chain is dominated by middle aged people. Four stages that existed on the supply chain included gatherers, farmers, herbal medicine producers and the final consumers. The highest supply source, which cut across all the actors in supply chain, was through gathering. This was followed by farmers. The least supply source was through importation. Farmers, gatherers and medicinal plant traders have non-concentrated market (0.07, 0.02 and 0.09), while Herbal Medicine (HM) producers had a moderately concentrated market (0.23). Binding prices, price regulation and barrier to entry and exit were inconspicuous. In general, the chain was adjudged to operate a fairly free market system. The enterprises were profitable with an average gross margin ratio of 0.76 for gatherers, 0.58 for farmers, 0.48 for traders and 0.46 for HM producers.Conclusion: The study examined the structure and conduct of the medicinal plants chain in the study area, and the chain was adjudged to operate a fairly free market system.
      PubDate: 2020-10-22
      DOI: 10.4102/jomped.v4i1.93
      Issue No: Vol. 4, No. 1 (2020)
       
  • Antioxidant assessment of characterised essential oils from Calophyllum
           inophyllum Linn using 2,2-diphenyl-1-picrylhydrazyl and hydrogen peroxide
           methods

    • Authors: Emmanuel O. Ojah, Dorcas O. Moronkola, Paul M. Osamudiamen
      First page: 9
      Abstract: Background: Oxidative stress is a multifactorial global health disorder that disrupts all levels of cell function. Therefore, therapeutic intervention using reliable, affordable and non-toxic natural sources is crucial.Aim: The aim of this article was to determine the chemical constituents and antioxidant activity of 10 essential oils (EOs) from Calophyllum inophyllum Linn using 2,2-diphenyl-1- picrylhydrazyl (DPPH) and hydrogen peroxide (H2O2) methods.Setting: Plant sample was collected at the Botanical Garden, University of Ibadan, Nigeria. Extractions and antioxidant assay were performed at the Organic Chemistry Research Laboratory, University of Ibadan, Nigeria. Gas chromatography-mass spectrophotometry (GC-MS) analysis was carried out at the School of Pharmacy, University of Camerino, Italy.Methods: The chemical constituents were determined using GC-MS. The oils were extracted using an all-glass Clevenger-type apparatus and the antioxidant activity was determined using DPPH and hydrogen peroxide assays.Results: A total of 102 compounds were identified in EOs from C. inophyllum Linn, which are mostly monoterpenes, sesquiterpenes and their oxygenated derivatives. The oils exhibited concentration-dependent activity with reference to standard synthetic antioxidants. Root wood had the highest antioxidant activity with the half maximal inhibitory concentration (IC50) of 3.19 mg/mL compared to ascorbic acid (2.84 mg/mL) and butylated hydroxyl anisole (BHA) (2.97 mg/mL). In the H2O2 antioxidant assay, root wood had the highest antioxidant activity with IC50 of 2.78 mg/mL compared to ascorbic acid (2.20 mg/mL) and BHA (2.92 mg/mL).Conclusion: The in vitro chemical compositional analysis of EOs from C. inophyllum Linn confirms the presence of compounds responsible for the antioxidant properties of the plant.
      PubDate: 2020-09-08
      DOI: 10.4102/jomped.v4i1.83
      Issue No: Vol. 4, No. 1 (2020)
       
 
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