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  Subjects -> ALTERNATIVE MEDICINE (Total: 111 journals)
Showing 1 - 15 of 15 Journals sorted alphabetically
Acupuncture & Electro-Therapeutics Research     Full-text available via subscription   (Followers: 8)
Acupuncture and Related Therapies     Hybrid Journal   (Followers: 10)
Acupuncture in Medicine     Hybrid Journal   (Followers: 19)
Advanced Herbal Medicine     Open Access   (Followers: 8)
Advances in Traditional Medicine     Hybrid Journal   (Followers: 8)
African Journal of Traditional, Complementary and Alternative Medicines     Open Access   (Followers: 7)
Akupunktur & Aurikulomedizin     Full-text available via subscription   (Followers: 1)
Allgemeine Homöopathische Zeitung     Hybrid Journal   (Followers: 3)
Alternative & Integrative Medicine     Open Access   (Followers: 16)
Alternative and Complementary Therapies     Hybrid Journal   (Followers: 22)
Alternative Medicine     Full-text available via subscription   (Followers: 4)
Alternative Medicine Studies     Open Access   (Followers: 14)
Anales de Hidrología Médica     Open Access   (Followers: 2)
Ancient Science of Life     Open Access   (Followers: 6)
Arabian Journal of Medicinal and Aromatic Plants     Open Access   (Followers: 4)
Arteterapia. Papeles de arteterapia y educación artística para la inclusión social     Open Access   (Followers: 5)
Asian Journal of Plant Pathology     Open Access   (Followers: 4)
Australian Journal of Acupuncture and Chinese Medicine     Full-text available via subscription   (Followers: 4)
Australian Journal of Herbal Medicine     Full-text available via subscription   (Followers: 5)
Australian Journal of Music Therapy     Full-text available via subscription   (Followers: 11)
Avicenna Journal of Phytomedicine     Open Access   (Followers: 1)
AYU : An international quarterly journal of research in Ayurveda     Open Access   (Followers: 6)
BMC Complementary and Alternative Medicine     Open Access   (Followers: 23)
Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas     Open Access   (Followers: 2)
Botanics : Targets and Therapy     Open Access   (Followers: 6)
Cadernos de Naturologia e Terapias Complementares     Open Access   (Followers: 1)
Chinese Herbal Medicines     Full-text available via subscription   (Followers: 1)
Chinese Medicine     Open Access   (Followers: 5)
Cognitive Neuroscience     Hybrid Journal   (Followers: 31)
Complementary Therapies in Clinical Practice     Hybrid Journal   (Followers: 23)
Complementary Therapies in Medicine     Hybrid Journal   (Followers: 19)
Current Traditional Medicine     Hybrid Journal   (Followers: 5)
Deutsche Heilpraktiker-Zeitschrift     Hybrid Journal   (Followers: 3)
Deutsche Zeitschrift für Akupunktur     Full-text available via subscription   (Followers: 2)
Erfahrungsheilkunde     Hybrid Journal   (Followers: 1)
European Journal of Medicinal Plants     Open Access  
Evidence-based Complementary and Alternative Medicine     Open Access   (Followers: 30)
Experimental and Therapeutic Medicine     Full-text available via subscription   (Followers: 1)
Fitoterapia     Hybrid Journal   (Followers: 9)
Focus on Alternative and Complementary Therapies     Hybrid Journal   (Followers: 12)
Global Journal of Integrated Chinese Medicine and Western Medicine     Open Access   (Followers: 1)
Global Journal of Traditional Medicine     Open Access   (Followers: 2)
Herba Polonica     Open Access   (Followers: 1)
Herbal Medicines Journal     Open Access   (Followers: 1)
Indian Journal of Research in Homoeopathy     Open Access   (Followers: 2)
Indian Journal of Traditional Knowledge (IJTK)     Open Access   (Followers: 2)
Innovare Journal of Ayurvedic Sciences     Open Access   (Followers: 10)
Intas Polivet     Full-text available via subscription   (Followers: 5)
Integrative Medicine Research     Open Access   (Followers: 3)
International Journal of Health and Medicine     Open Access   (Followers: 1)
International Journal of High Dilution Research     Open Access  
International Journal of Qualitative Studies on Health and Well-Being     Open Access   (Followers: 22)
International Journal of Yoga     Open Access   (Followers: 17)
International Journal of Yoga : Philosophy, Psychology and Parapsychology     Open Access   (Followers: 7)
Ipnosi     Full-text available via subscription  
Journal of Acupuncture and Herbs     Open Access   (Followers: 3)
Journal of Acupuncture and Meridian Studies     Open Access   (Followers: 1)
Journal of Acupuncture and Tuina Science     Hybrid Journal   (Followers: 4)
Journal of Alternative and Complementary Medicine     Hybrid Journal   (Followers: 17)
Journal of Applied Arts and Health     Hybrid Journal   (Followers: 1)
Journal of Applied Research on Medicinal and Aromatic Plants     Hybrid Journal   (Followers: 1)
Journal of Asian Natural Products Research     Hybrid Journal   (Followers: 5)
Journal of Ayurveda and Integrative Medicine     Open Access   (Followers: 7)
Journal of AYUSH :- Ayurveda, Yoga, Unani, Siddha and Homeopathy     Full-text available via subscription   (Followers: 10)
Journal of Bodywork and Movement Therapies     Hybrid Journal   (Followers: 18)
Journal of Complementary and Alternative Medical Research     Open Access   (Followers: 1)
Journal of Complementary and Integrative Medicine     Hybrid Journal   (Followers: 12)
Journal of Dance Medicine & Science     Full-text available via subscription   (Followers: 14)
Journal of Evidence-Based Integrative Medicine     Open Access   (Followers: 18)
Journal of Fasting and Health     Open Access   (Followers: 1)
Journal of Ginseng Research     Open Access  
Journal of Health Science and Alternative Medicine     Open Access   (Followers: 1)
Journal of Health Sciences Scholarship     Open Access  
Journal of Herbal Drugs (An International Journal on Medicinal Herbs)     Open Access   (Followers: 1)
Journal of Herbal Medicine     Hybrid Journal   (Followers: 2)
Journal of Herbal Science     Full-text available via subscription   (Followers: 6)
Journal of Integrative Medicine     Full-text available via subscription   (Followers: 4)
Journal of Integrative Medicine & Therapy     Open Access   (Followers: 2)
Journal of Manual & Manipulative Therapy     Hybrid Journal   (Followers: 17)
Journal of Medicinal Plants for Economic Development     Open Access  
Journal of Medicinally Active Plants     Open Access   (Followers: 2)
Journal of Natural Remedies     Open Access   (Followers: 3)
Journal of Nutraceuticals and Herbal Medicine     Open Access   (Followers: 4)
Journal of Palliative Medicine     Hybrid Journal   (Followers: 48)
Journal of the Australian Traditional-Medicine Society     Full-text available via subscription   (Followers: 1)
Journal of Traditional and Complementary Medicine     Open Access   (Followers: 4)
Journal of Traditional Chinese Medical Sciences     Open Access   (Followers: 1)
Journal of Yoga & Physical Therapy     Open Access   (Followers: 9)
Lekovite Sirovine     Open Access  
Médecine Palliative : Soins de Support - Accompagnement - Éthique     Full-text available via subscription   (Followers: 2)
Medical Acupuncture     Hybrid Journal   (Followers: 6)
Medicines     Open Access   (Followers: 1)
Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi ve Folklorik Tıp Dergisi     Open Access  
Muller Journal of Medical Sciences and Research     Open Access  
Natural solutions     Full-text available via subscription  
Natural Volatiles & Essential Oils     Open Access   (Followers: 1)
Nigerian Journal of Natural Products and Medicine     Full-text available via subscription  
OA Alternative Medicine     Open Access   (Followers: 1)
Oriental Pharmacy and Experimental Medicine     Partially Free   (Followers: 3)
Research Journal of Medicinal Plant     Open Access   (Followers: 2)
Research Journal of Pharmacognosy     Open Access  
Revista Brasileira de Plantas Medicinais     Open Access   (Followers: 1)
Revista Internacional de Acupuntura     Full-text available via subscription  
South African Journal of Plant and Soil     Hybrid Journal   (Followers: 1)
Synfacts     Hybrid Journal   (Followers: 7)
Traditional & Kampo Medicine     Full-text available via subscription  
Traditional Medicine Journal     Open Access   (Followers: 2)
World Journal of Acupuncture - Moxibustion     Full-text available via subscription   (Followers: 1)
World Journal of Traditional Chinese Medicine     Open Access   (Followers: 1)
Yoga Mimamsa     Open Access   (Followers: 2)
Zeitschrift für Orthomolekulare Medizin     Hybrid Journal   (Followers: 2)

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Avicenna Journal of Phytomedicine
Journal Prestige (SJR): 0.535
Citation Impact (citeScore): 3
Number of Followers: 1  

  This is an Open Access Journal Open Access journal
ISSN (Print) 2228-7930 - ISSN (Online) 2228-7949
Published by Mashhad University of Medical Sciences Homepage  [15 journals]
  • Topical formulations containing Copaifera duckei Dwyer oleoresin improve
           cutaneous wound healing

    • Abstract: Objective: Evaluation of the healing and toxicological effects of Copaifera duckei Dwyer oleoresin (CDO).Materials and Methods: Rodents with skin lesions were divided into nine groups, including daily treatments with 1, 3 and 10% CDO, collagenase, antibiotic ointment and control groups, for 14 days.Results: Treatment with 10% CDO reduced skin edema and hyperplasia, demonstrating anti-inflammatory effect of the oil. Reduction in the wound area was observed, indicating the healing effect of CDO. Histopathological analysis showed increases in angiogenesis and re-epithelialization in animals treated with the highest concentration. On the other hand, no alterations in ulcerations, inflammatory infiltrate, hemorrhage, congestion, degeneration, percentage of collagen fibers, number of cells stained with anti-macrophage migration inhibitory factor, or density of area stained with anti-collagen I and III were found. Toxicogenetic analysis revealed no differences in micronucleus frequencies or in the ratio of polychromatic erythrocytes to total erythrocytes between treated and negative control, demonstrating the absence of genotoxicity and cytotoxicity, respectively. There was no difference in levels of liver enzymes among groups, indicating the absence of hepatotoxicity.Conclusion: Formulations of CDO exerted beneficial effects on the stages of cutaneous wound healing and are promising options for the treatment of wounds. 
      PubDate: Sat, 10 Oct 2020 20:30:00 +010
       
  • Arbutin attenuates nephrotoxicity induced by gentamicin

    • Abstract: Objective: In this study, the impact of arbutin was examined in a gentamicin (GM)-induced nephrotoxicity model. Materials and Methods: Forty adult male Wistar rats were randomly assigned to five groups including control group; GM group, and three groups of GM+arbutin (25, 50 and 75 mg/kg). One day after the last injection of GM, creatinine, urea, carbonyl, thiobarbituric acid-reacting substance (TBARs), ferric reducing antioxidant power (FRAP) and 8-hydroxyguanosine levels were assessed in serum samples. Left and right kidneys were used for biochemical assays and histological evaluation, respectively. Results: Our data showed that the FRAP level (p <0.05), urea (p <0.001), creatinine (p <0.001), and 8-hydroxyguanosine (p <0.001) levels of serum samples, were increased in GM-treated rats compared to the controls. The serum levels of TBARS (p <0.001) and carbonyl increased in serum and renal tissue (p <0.001) of GM-treated animals. Conversely, arbutin attenuated serum creatinine, urea and 8-hydroxyguanosine, and TBARS (p <0.001). Administration of arbutin significantly decreased carbonyl levels in serum and renal tissue samples (p <0.001). Furthermore, the levels of FRAP increased in the serum (p <0.01) and renal tissue samples (p <0.001) of arbutin-treated animals. Histological staining showed that arbutin significantly inhibits kidney damages. Conclusion: Our data suggest that arbutin attenuates GM-induced nephrotoxicity through its free radicals-scavenging activity.
      PubDate: Sat, 03 Oct 2020 20:30:00 +010
       
  • Abscisic acid interplays with PPARγ receptors and ameliorates
           diabetes-induced cognitive ...

    • Abstract: Objective: This study intended to evaluate if central administration of abscisic acid (ABA) alone or in combination with GW9662, a peroxisome proliferator–activated receptor γ (PPAR-γ) antagonist, could modulate learning and memory as well as hippocampal synaptic plasticity in a rat model of streptozotocin (STZ)–induced diabetes.Materials and Methods: Intraperitoneal injection of STZ (65 mg/kg) was used to induce diabetes. Diabetic rats were than treated with intracerebroventricular (i.c.v.) administration of ABA (10, 15 and 20 µg/rat), GW9662 (3 µg/rat) or GW9662 (3 µg/rat) plus ABA (20 µg/rat).Animals’ spatial and passive avoidance learning and memory performances were assessed by Morris water maze (MWM) and shuttle box tasks, respectively. Further, in vivo electrophysiological field recordings were assessed in the CA1 region.Results: STZ diabetic rats showed diminished learning and memory in both MWM and shuttle box tasks.  The STZ-induced memory deficits were attenuated by central infusion of ABA (10 and 20 µg/rat). Besides, STZ injection impaired long-term potentiation induction in CA1 neurons that was attenuated by ABA at 20 μg/rat. Central administration of GW9662 (3 µg/rat) alone did not modify STZ-induced spatial and passive avoidance learning and memory performances of rats. Further, GW9662 prevented ABA capacity to restore learning and memory in behavioral and electrophysiology trials.Conclusion: Altogether, ABA ameliorates cognitive deficits in rats via activation of PPAR-γ receptor in diabetic rats.
      PubDate: Sat, 03 Oct 2020 20:30:00 +010
       
  • Protective effects of the fruit extract of raspberry (Rubus fruticosus L.
           ...

    • Abstract: Objective: Protective effects of raspberry (Rubus fruticosus L.) fruit extract on pituitary-gonadal axis and testicular tissue in diabetic male rats, were investigated.Materials and Methods: Sixty male rats were divided into control, sham (saline treated), streptozotocin (STZ)-diabetic, and STZ-diabetic animals treated with 50, 100 and 200 mg/kg/day of raspberry extract. After 4 weeks, blood samples were obtained and left testes were removed and prepared for histopathological studies. Serum levels of Luteinizing hormone (LH), Follicle stimulating hormone (FSH), testosterone, Nitric oxide (NO), and malondialdehyde (MDA), as well as superoxide dismutase (SOD) and catalase (CAT) activity level were assayed. Sperm number and motility in the epididymis samples were measured. Data were analyzed using ANOVA (one-way analysis of variance).Results: Serum levels of LH, FSH and MDA significantly increased in diabetic rats, however, treatment with the extract significantly reversed the alterations. Serum levels of testosterone and NO, activity of SOD and CAT, and sperm number and motility significantly decreased and severe destruction of testicular histology was observed in diabetic animals while treatment with the extract significantly reversed the pathologic alterations observed in diabetic rats.  According to the results, 100 and 200 mg/kg of the extract were able to effectively reverse the diabetes complications.Conclusion: Our findings demonstrated that the fruit extract of raspberry has protective effects on male reproductive system in diabetic rats partially due to its improving effects on NO system, and SOD and CAT activity.
      PubDate: Fri, 02 Oct 2020 20:30:00 +010
       
  • Phytochemical standardization, formulation and evaluation of oral hard
           gelatin capsules from ...

    • Abstract: Objective:The extract of Pinus eldarica bark contains many polyphenolic compounds that were studied due to their high antioxidant, anti-inflammatory and anti-mutagenic effects. Therefore, the purpose of the present study was to conduct phytochemical standardization and develop hard gelatin capsules from the extract of P. eldarica bark.Materials and Methods:Extraction was carried out by maceration method at room temperature for 72 hr using ethanol 70% followed by freeze drying. Quantification and standardization tests were performed using Folin-Ciocalteu method. Then, nine formulations were prepared containing different amounts of stearic acid (1-3%) and corn starch (3%, 10%, and 25%). Each formulation was characterized by FTIR and pharmacopoeial tests such as drug content, disintegration time, flowability parameters and drug release percent. The optimized formulation underwent stability studies at 75±5% humidity and 40±2°C.Results:The total phenolic content of the extract in terms of gallic acid equivalent was 362.8±5.4 mg/g and the total procyanidin content in the extract was 174.386±2.5 mg/g. FTIR revealed no interaction between the components. The results presented that the best formulation of the capsules was achieved they contained 3% of stearic acid and 25% of corn starch. This formulation showed 91.69±0.33% of drug content, 9.36±0.02 min disintegration time and 83.02±0.81% release percent. Moreover, it showed good flowability. Stability studies on the optimized formulation displayed that the formulation was stable within 6 months in the accelerated condition.Conclusion: In conclusion, results of the present phytopharmaceutical evaluations confirmed this product as a promising herbal capsule formulation.
      PubDate: Fri, 25 Sep 2020 20:30:00 +010
       
  • In vitro and in vivo evaluation of antibacterial and anti-biofilm
           properties of five ...

    • Abstract: Objective: The aim of the present study was to investigate antibacterial and antibiofilm activity of a few medicinal plants against oral bacteria.Materials and Methods: Salvia officinalis, Lippie citriodora, Mentha piperita, Echinacea purpurea and Matricaria chamomilla were extracted. Isolates from oral cavity were identified by microbiological and molecular methods. Minimum inhibitory concentration and minimum bactericidal concentration were determined by Broth microdilution method. The anti-biofilm activity of essential oils and extracts investigated and as a mixture by Broth dilution method. Toxicity of the herbal mixture was assayed by in Wistar rats treated with intradermal injection. Wound healing properties of the herbal mixture against infected wounds on the back of the rats were investigated. Anti-biofilm activity was investigated on tooth surfaces. Bacterial structure changes and fine- structure study were performed by light microscopy and Transmission electron microscopy.Results: The lowest MIC and MBC for the plant mixtures was 0.0002 mg/ml belonged to Streptococcus pyogenes and the highest values (0.025 mg/ml) belonged to Eikenella corrodens. The essential oils of S. officinalis, L. citriodora and M. piperita, but not E. purpurea and M. chamomilla extracts, were able to remove the biofilms created by the studied bacteria. The herbal mixture was able to completely heal the wound skin of rats in 21 days (p<0.05 compared to control). The mixture was able to decompose the teeth biofilm in 45 seconds. The results of light and electron microscopy showed that the bacterial structure exposed to the herbal mixture was deformed.Conclusion: It was concluded that the essential oils of S. officinalis, L. citriodora and M. piperita had significant effects on inhibition of oral bacteria biofilm formation.
      PubDate: Fri, 25 Sep 2020 20:30:00 +010
       
  • Anti-inflammatory, antioxidant and antinociceptive activities of Russelia
           coccinea (L.) Wettst.

    • Abstract: Objective: Some species of the Russelia genus have been used  different illnesses associated with pain and inflammation. The aim of this work was to characterize the biological activities (anti-inflammatory and analgesic) and antioxidant capacity of methanol and dichloromethane extracts of Russelia coccinea.Materials and Methods: In this study, topical anti-inflammatory activity was tested in an in vivo model of 12-O-tetradecanoylphorbol acetate (TPA) induced mouse ear edema of organic extracts (doses: 0.03, 0.1, and 0.3 mg/ear). The antinociceptive activity was assessed using the formalin test in mice of organic extracts (doses: 56, 100 and 300 mg/kg ). Moreover, the antioxidant capacity of the extracts was determined using 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azinobis(3-ethylbenzothiaziline-6-sulfonate) (ABTS) and ferric reducing antioxidant power (FRAP) assays.Results: Methanol (RcM) and dichloromethane (RcD) extracts of the R. coccinea aerial parts were found to inhibit ear edema (48.95 and 40.13%, respectively) at a dose of 0.3 mg/ear. Acute treatment with RcM produced a significant antinociceptive effect in the late phase of formalin-induced nociception. Moreover, RcM at doses of 56, 100 and 300 mg/kg showed a significant antinociceptive effect through the early and late phases in the formalin test. RcM and RcD showed weak antioxidant capacities in the ABTS and DPPH assays; however, when their reducing capacity was evaluated by the FRAP assay, RcM showed a reducing activity similar to Camellia sinensis standard at the proven concentration of 1000 μg/ml.Conclusion: According to the experimental findings, the organic extracts of R. coccinea display remarkable antinociceptive and anti-inflammatory activities.
      PubDate: Fri, 25 Sep 2020 20:30:00 +010
       
  • The positive effect of short-term nano-curcumin therapy on insulin
           resistance and serum levels ...

    • Abstract: Objective: Metabolic syndrome (MS) is a cluster of cardio-metabolic risk factors. MS is known as a highly prevalent disease worldwide. According to the existing evidence, consuming curcumin has positive effects on lipids profile, glucose, and body weight. This study aimed to evaluate the effects of nano-curcumin therapy on insulin resistance and serum level of afamin in patients with MS.Materials and Methods: Thirty MS patients (15 males and 15 females) received 80 mg/daily nano-curcumin for two months. The samples of fasting blood were collected from the participants at the beginning and 60 days after initiation of the intervention to measure biomarkers.Results: Comparing pre- and post-treatment with nano-curcumin values revealed a significant decrease in fasting plasma glucose (FPG) (p=0.017), insulin, homeostatic model assessment of insulin resistance (HOMA-IR) (p=0.006), and afamin (p=0.047). Moreover, there was a significantly negative relationship between afamin and high-density lipoprotein cholesterol (HDL-C) (p=0.044), as well as a significantly positive relationship between afamin and systolic (SBP) (p<0.001) and diastolic (DBP) (p<0.001) blood pressures.Conclusion: Results suggest that taking nano-curcumin for 60 days may have positive effects on afamin, FPG, insulin, and HOMA-IR in patients with MS, but would not significantly affect other metabolic profiles. More studies with larger sample sizes are required to confirm these findings.
      PubDate: Mon, 21 Sep 2020 20:30:00 +010
       
  • The effect of ginger (Zingiber officinale) feed on cardiac biomarker in
           medium-dose ...

    • Abstract: Objectives- Traditional medicines have been widely used to prevent and treat diseases for thousands of years. This study was designed to evaluate the effect of ginger feed on cardiac biomarker in isoproterenol induced myocardial toxicity. Materials and Methods- Thirty male wistar rats were grouped into six groups of 5 rats each: Control; ISO- induced toxicity; ginger fed ; ginger fed before; ginger fed+ isoproterenol simultaneously and ginger fed after. Freshly prepared solution of isoproterenol was injected subcutaneously at a dosage of 20mg/kg, while the control recieved distilled water. Blood was collected via cardiac puncture after two weeks of administration, the serum was used to evaluate biomarkers. Results- The CK-MB of ginger fed groups was significantly lower (p < 0.05) compared to ISO group(8.2 ± 0.5µ/L). The CK of the ginger fed groups showed significant decrease (p>0.05) compared to isoproterenol group (39.36±5.28 µ/L), there was no significant difference in the CK-MB and CK levels of all the groups fed with ginger compared to the control(2.2± 0.3µ/L; 17. 07 ± 3.4.90 µ/L) except the group that was fed with ginger after isoproterenol induction, which was significantly higher compared to the control(p>0.05). The mean value of LDH were lower in all ginger treated groups compared to the ISO group (67.17± 0.88; p≤ 0.05), but significantly higher (p < 0.05) compared to the control(26.45 ± 2.52). The mean value of ALT were lower in all ginger fed groups compared to the ISO group (83.11± 4.88; p ≤ 0.05). Conclusion- Ginger feed hindered toxic effects of isoproterenol.
      PubDate: Mon, 21 Sep 2020 20:30:00 +010
       
  • Protective effect of the olive hydroalcoholic extract on estrogen
           deficiency-induced bone loss ...

    • Abstract: Objective: Osteoporosis, as a skeletal disorder caused by aging, is considered a major health problem. This work was planned to assess the effect of the black olive hydroalcoholic extract on bone mineral density and biochemical parameters in ovariectomized rats.Materials and Methods: Ninety 6-month-old female Sprague Dawley rats were randomly assigned into 7 sets: control (received saline); sham-operated control, Ovariectomized (OVX) rats (received saline); 3 groups of black olive-supplemented OVX rats (respectively, receiving 250, 500, and 750 mg/kg body wt black olive extract orally); and estrogen group (receiving 3 mg/kg/day estradiol valerate). Blood samples were collected 2, 4 and 6 months after treatment to measure calcium (Ca), alkaline phosphatase (ALP), and phosphorus (P). Dual-energy X-ray absorptiometry (DEXA) was applied to measure the bone mineral density (BMD). Global, lumbar spine and lower limb BMD was measured.Results: Ca concentration was significantly increased in the group treated with the highest dose of black olive hydroalcoholic compared to the OVX group (P<0.001). In addition, a significant decrease in ALP concentrations in the group treated with the highest dose of black olive hydroalcoholic comparing with the OVX group was observed (P<0.001). The global, tibia, femur and spine BMD in the group treated with the highest dose of black olive hydroalcoholic and estrogen group were significantly increased compared to the OVX group (P<0.05).Conclusion: Black olive hydroalcoholic extract at the dose of 750 mg/kg, prevented bone loss and augmented bone mineral density and could be a possible candidate for the management of osteoporosis.
      PubDate: Mon, 07 Sep 2020 19:30:00 +010
       
  • Ginger (Zingiber officinale roscoe) extract could upregulate the renal
           expression of NRF2 and ...

    • Abstract: Objective: Ginger has protective effects on the kidney, however the molecular mechanism of this effect has not yet been fully elucidated. Therefore, this work studied molecular mechanisms of ginger effects on ethanol-induced kidney injury. Materials and Methods: Twenty-four male Sprague-Dawley rats were randomly divided into four groups: control, ginger (1 g/kg/day ginger extract by oral gavage), ethanol (4 g/kg/day ethanol by oral gavage) and ginger-ethanol group and treated daily for 28 days. Kidney function, expression of nuclear factor erythroid 2-related factor 2 (NRF2) and tumor necrosis factor (TNF)-α genes and oxidative stress parameters in kidney tissue, were evaluated. Total phenolic content (TPC) and 2, 2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity of ginger extract were also evaluated.  Results: Hydroethanolic extract of ginger showed a good level of DPPH scavenging activity and TPC.  In the ethanol group,  serum level of urea, creatinine and uric acid and the expression of NRF2 and TNF-α significantly increased compared to control group, while co-treatment with ginger in ginger+ethanol group significantly ameliorated them compared to the ethanol group. Ethanol exposure significantly reduced the activity of superoxide dismutase  (SOD), glutathione peroxidase (GPx) and catalase (CAT) compared to the control values ,while the level of malondialdehyde (MDA) significantly increased. Ginger significantly ameliorated the level of MDA and activity of SOD, GPx and CAT in the ginger-ethanol group compared to the ethanol group. Conclusion: The results showed that ginger's protective effects against ethanol renotoxicity were mediated via enhancing the NRF2 and TNF-α expression.
      PubDate: Sat, 05 Sep 2020 19:30:00 +010
       
  • Effects of crocin on spatial or aversive learning and memory impairments
           induced by ...

    • Abstract: Objective: Neuroinflammation and oxidative stress play essential roles in the pathogenesis and progression of neurodegenerative diseases, such as Alzheimer’s disease. Crocin, main active constituent of Crocus sativus L. (saffron), possesses anti-inflammatory, anti-apoptotic and anti-oxidative capacity. The aim of the present study was to investigate the neuroprotective effect of crocin on lipopolysaccharide (LPS)-induced learning and memory deficits and neuroinflammation in rats.Materials and Methods: The animals were randomly classified into four groups, including control, LPS, crocin 50 and crocin 100. The rats were treated with either crocin (50 and 100 mg/kg) or saline for a week. Later, LPS (1 mg/kg, i.p.) or saline was administered, and treatments with crocin or saline were continued for 3 more weeks. The behavioral tasks for spatial and aversive memories were performed by the Morris water maze and passive avoidance tasks from post-injection days 18 to 24. Furthermore, the levels of interleukine-1β, lipid peroxidation and total thiol were assayed in the hippocampus and cerebral cortex.  Results: Our results demonstrated that treatment of LPS-treated rats with crocin decreased the escape latency in the Morris water maze and increased the time spent in the target quadrant in the probe trial. Moreover, crocin increased step-through latency in the passive avoidance test. However, there was no significant difference in the oxidative and neuroinflammatory responses among the experimental groups. Conclusion: Pretreatment with crocin attenuates spatial or aversive learning and memory deficits in LPS-treated rats.
      PubDate: Fri, 04 Sep 2020 19:30:00 +010
       
  • Aqueous extract of Tamarindus indica fruit pulp exhibits
           antihyperglycaemic activity

    • Abstract: Objective: Tamarindus indica Linn.(T.indica) is a well-known plant used in traditional medicine. The plant is popular for its antidiabetic activity. However, effect so f its aqueous fruit pulp extract on carbohydrate hydrolyzing enzymes and its glucose uptake potential were not explored. Materials and Methods: The antidiabetic activity was assessed by in-vitro α-amylase and α-glucosidase inhibitory assays after preliminary phytochemical analysis. MTT assay was carried out to find cytotoxicity. Glucose uptake activity of the extract was carried out using L6 myotubes. Results:The results showed a strong α-amylase inhibitory activity for the fruit pulp extract of T.indica compared to standard acarbose; the IC50 of the fruit pulp extract of T.indica and acarbose was 34.19 µg/ml 34.83µM. The extract also showed moderate α-glucosidase inhibitory activity. IC50 of the fruit pulp extract of T.indica and acarbose were 56.91µg/ml and 45.69µM respectively. The cytotoxicity assay showed IC50 of >300µg/ml and ≥1000µM for the fruit pulp extract of T.indica     and metformin. The extract showed 63.99±0.08% glucose uptake in L6 myotubes whereas metformin and insulin at  10µg/ml and 10µM exhibited an uptake of 76.99±0.3% and 84.48±0.45% glucose, respectively. Conclusion: The study revealed that the fruit pulp extract of T.indica Linn does not show any cytotoxic effect and has very good α-amylase and good α-glucosidase inhibitory activities. The glucose uptake potential proves its postprandial hypoglycemic effect. Hence, it may be considered an antidiabetic agent for control of postprandial hyperglycemia.
      PubDate: Mon, 31 Aug 2020 19:30:00 +010
       
  • Evaluation of phytochemical and pharmacological properties of seeds of
           Momordica charantia

    • Abstract: Objective: The purpose of the current study was to investigate the in vivo (analgesic, antidiarrheal, neurological, and cytotoxic) and in vitro (antioxidant, antimicrobial, thrombolytic and anthelmintic) activity of different fractions of methanolic extract of Momordica charantia. Materials and Methods: The antioxidant property was evaluated by DPPH radical scavenging assay, while antimicrobial activity was examined against three Gram (+) and one Gram (-) bacteria. Thrombolytic and anthelmintic activities were evaluated by using human blood serum and by recording paralysis and death time in earthworm, respectively. Cytotoxic activity was investigated in brine shrimp nauplii. Analgesic and antidiarrheal activities were evaluated in Swiss albino mice and neurological effect was evaluated by open field and Elevated plus-maze test (EPM). Results: All fractions (n-hexane, carbon tetrachloride and chloroform) possess significant (p<0.05) cytotoxic activity. In case of thrombolytic activity, the highest concentration of methanolic extract produced a remarkable percentage of clot lysis (46.12%). The concentration of 1000 μg/ml produced a significant antibacterial activity against Gram positive Staphylococcus aureus and Gram negative E. coli. Aqueous fraction at a dose of 400 mg/kg body weight, was found to show promising analgesic activity. In case of antidiarrheal and anthelmintic activity, plant extract showed dose-dependent activity. Methanolic extract and its fractions failed to produce any neurological effect in both methods. Conclusion: The overall results of the study tend to suggest that the methanolic extract and its fractions have promising pharmacological activities.
      PubDate: Mon, 31 Aug 2020 19:30:00 +010
       
  • Azelaic acid stimulates catalase activation and promotes hair growth
           through upregulation of ...

    • Abstract: Objective: Although azelaic acid is effective for treatment of acne and rosacea, the biological activity of azelaic acid and the effect of its combination therapy with minoxidil were not elucidated with regard to hair growth. Materials and Methods: In this study, mouse vibrissae follicles were dissected on day 10 after depilation. Then, the bulb and bulge cells of the hair follicle were treated with minoxidil and azelaic acid for 10 days to evaluate Sonic hedgehog (Shh) protein expression. Moreover, bulge and bulb cells of the hair follicles were cultivated and the expression of Gli1, Gli2, and Axin2 mRNA levels was evaluated using real-time polymerase chain reaction (PCR) analysis. We further investigated the protective effects of azelaic acid against ultraviolet B (UVB) irradiation in cultured bulb and bulge cells by determining catalase activity. An irradiation dose of 20 mJ/cm2 UVB for 4 sec was chosen. Results: The results showed that catalase activity significantly (p<0.05) increased in the bulge cells after exposureto 2.5 mM and 25 mM azelaic acid. Meanwhile, treatment of the bulb cells with azelaic acid (2.5 and 25 mM) did not cause significant changes in catalase activity. We also found that azelaic acid (25 mM) alone upregulated Gli1 and Gli2 expression in the bulge cells and 100 µ minoxidil caused Gli1 and Axin2 overexpression in the bulb region of the hair follicle. Moreover, minoxidil (100 µM) alone and in combination with azelaic acid (25 mM) led to Shh protein overexpression in the hair follicles in vitro and in organ culture. Conclusion: Our results indicated a potential role for azelaic acid in the protection of bulge cells from UVB damage and its combination with minoxidil may activate hair growth through overexpression of Shh protein.
      PubDate: Mon, 31 Aug 2020 19:30:00 +010
       
  • The effects of lettuce extract on the level of T4, memory and nerve
           conduction velocity in male rats

    • Abstract: Objective: According to the traditional medicine,lettuce can affect nerve conduction velocity and memory. So, to investigate the effect of lettuce seeds extract on body activities, lettuce seeds were used. Materials and Methods: In the present study, the effects of lettuce (Lactuca sativa) seeds extract consumption (in drinking water) on T4 level, animals' weight, water and food consumption, nerve conduction velocity (NCV), and memory in Wistar rats, were investigated. In this study, 24 Wistar rats were used, and divided into three groups: control, L 200 mg/kg, and L 400 mg/kg. Results: The results showed that, the T4 level, food and water intake, time spent and distance travelled in Q1, delay time to enter and the number of entrance into the dark room in both treated groups were not significantly different from the control group. Animal weight and NCV, in 400 mg/kg group were not significantly different from the control group, but in 200 mg/kg group, they were significantly decreased (p<0.05). The duration spent in  the dark room (48 hr after shock) in L 400 mg/kg increased compared to the control group (p<0.05), but in L 200 mg/kg group at all time points, and in L 400 mg/kg treated group 3 and 24 hr after shock, it was not significantly different from the control group. Conclusion: Based on these findings, the T4 level, memory, food and water intake were not changed by lettuce extract, while NCV and animal weight were decreased following treatment with lettuce extract.
      PubDate: Mon, 31 Aug 2020 19:30:00 +010
       
  • Evaluation of the influence of chamomile vaginal gel on dyspareunia and
           sexual satisfaction in ...

    • Abstract: Objective: The purpose of this study was to determine the effect of chamomile vaginal gel on dyspareunia and sexual satisfaction in postmenopausal women. The phytoestrogenic properties of Matricaria chamomilla were the reason for selection of this plant. Materials and Methods: This double-blind clinical trial research was conducted on 96 eligible postmenopausal women referring to Gotvand city Health Center No. 1 in 2018. In this research, 96 postmenopausal women complaining from dyspareunia and sexual dissatisfaction were randomly assigned into three groups (each contained 32 subjects) to receive 5% chamomile vaginal gel, conjugated estrogen vaginal cream and placebo gel, for 12 weeks. All women completed the Larsson and a four-degree pain self-assessment questionnaires. Data was analyzed using SPSS version 22. A p-value of less than 0.05 was considered significant. Results: After the intervention period, a significant difference was seen between the intervention and the placebo group in the mean sexual satisfaction (p<0.001). Also, a significant reduction was seen in painful sexual intercourse between the groups using vaginal gel of chamomile and conjugated estrogen vaginal cream (95% CI: chamomile: 0.68-1.04, estrogen: 0.63-0.98, placebo: 1.8-2.1; p<0.001).  Conclusion: Using chamomile vaginal gel can cause a reduction in painful sexual intercourse and an increase in sexual satisfaction in postmenopausal women.
      PubDate: Mon, 31 Aug 2020 19:30:00 +010
       
  • Anti-inflammatory effect of Adiantum capillus-veneris hydroalcoholic and
           aqueous extracts on ...

    • Abstract: Objective: Colitis is an inflammatory bowel disease with unknown etiology where many factors might play a role.  Adiantum capillus-veneris mayhave beneficial effects in colitis because of its anti-inflammatory, antioxidant, wound healing and antimicrobial effects. The aim of this study was to explore the anti-inflammatory and anti-ulcerative effects of A. capillus-veneris on acetic acid-induced colitis in a rat model. Materials and Methods: A. capillus-veneris aqueous (ACAE; 150, 300, and 600 mg/kg) and hydroalcoholic extract (ACHE; 150, 300, and 600 mg/kg) were given orally (p.o.) to male Wistar rats 2 hr before induction of colitis by intra-rectal administration of acetic acid 3%, and continued for 4 days. Prednisolone (4 mg/kg) and mesalazine (100 mg/kg) were applied p.o., as reference drugs for comparison. On day five, colitis indices of tissue specimens were evaluated and levels of biochemical markers including myeloperoxidase (MPO) and malondialdehyde (MDA) were determined. Results: In all groups treated with ACAE and ACHE with the exception of ACAE (150 mg/kg), ulcer index and wet weight of colon as parameters of macroscopic injuries, total colitis index as marker of microscopic features and MPO activity were significantly reduced in comparison to the control group; however, MDA value was only diminished in ACAE (300 and 600 mg/kg) and ACHE (300 mg/kg) groups significantly. Conclusion: This research showed that ACAE and ACHE had dose-related beneficial effects on acetic acid-induced colitis and these effects could be attributed to anti-inflammatory, ulcer healing and antioxidant activities of these extracts.
      PubDate: Mon, 31 Aug 2020 19:30:00 +010
       
  • The role of Artemisia turanica extract on renal oxidative and biochemical
           markers in ...

    • Abstract: Objective: The aim of the current study was to investigate the protective effect of Artemisia turanica (AT) against diabetes- induced renal oxidative stress in rats. Materials and Methods: Fifty male Wistar rats were randomly divided into five groups: control, STZ-induced diabetic rats, diabetic rats+ metformin, diabetic rats + AT extract, diabetic rats+ metformin+ AT extract. In the present study, diabetes was induced by a single-dose (55 mg/kg, ip) injection of streptozotocin (STZ). Diabetic rats were daily treated with metformin (300 mg/kg), AT extract (70 mg/kg) and metformin+ AT extract for 4 consecutive weeks. Tissue activities of superoxide dismutase (SOD) and catalase and the levels of malondialdehyde (MDA) and total thiol content were measured in kidney tissue. Serum concentrations of glucose, creatinine, and urea, as well as, lipid profile were also measured. Results: STZ significantly increased the levels of glucose, triglyceride, urea and MDA compared to the control group. Total thiol content, as well as, catalase and SOD activities showed significant decreases in diabetic group when compared with the control animals. Serum glucose, triglyceride, cholesterol and renal MDA showed a significant decrease and renal total thiol and the activities of antioxidant enzymes showed significant increases in AT+STZ group compared with the diabetic group. In diabetic rats received AT+ metformin, serum LDL and HDL, renal MDA and SOD and catalase activities significantly improved compared with the diabetic rats. Conclusion: These findings suggested that AT extract has therapeutic effects on renal oxidative damage and lipid profile in diabetes, that possibly may be due to its antioxidant and hypolipidemic effects.
      PubDate: Mon, 31 Aug 2020 19:30:00 +010
       
  • Paraquat-induced systemic inflammation and increased oxidative markers in
           rats improved by ...

    • Abstract: Objective: Paraquat (PQ) is a herbicide which induces oxidative stress and inflammation. Anti-inflammatory and anti-oxidant effects were shown for Zataria multiflora (Z. multiflora) and carvacrol previously. The effects of Z. multiflora hydroalcoholic extract and carvacrol on systemic inflammation and oxidative stressinduced by inhaled PQ were examined in this study. Materials and Methods: Six groups of male rats used in this study were as follows: control group exposed to normal saline aerosol, one group exposed to PQ 54 mg/m3 aerosol, animals exposed to PQ 54 mg/m3 and treated with Z. multiflora (200 and 800 mg/kg/day) or carvacrol (20 and 80 mg/kg/day) for 16 days after the end of exposure to PQ. Exposure to PQ was performed 8 times, every other day, each time for 30 min. After the end of the treatment period, different variables were measured. Results: Significant increases in nitrite (NO2), malondialdehyde (MDA) and interleukin (IL)-6 serum levels but significant reduction of interferon-gamma (IFN-γ) serum levels as well as IFN-γ/IL-6 ratio were observed in PQ-exposed compared to control group (p2, and IL-6 but increased IFN-γ and IFN-γ/IL-6 ratio compared to un-treated PQ exposed group (p Conclusion: Treatment with Z. multiflora and carvacrol improved systemic inflammation oxidative biomarkers induced by inhaled PQ which may indicate therapeutic potential of the plant and its constituent, carvacrol in systemic inflammation and oxidative biomarkers induced by inhaled PQ.
      PubDate: Mon, 31 Aug 2020 19:30:00 +010
       
  • Comparison between Golnar product and placebo in heavy menstrual bleeding:
           A double-blind ...

    • Abstract: Objective: Golnar product is a poly herbal formulation advised by Persian medicine to control heavy menstrual bleeding (HMB). This study was conducted to compare the efficacy of this product with placebo in patients with HMB. Materials and Methods: In this double-blind randomized clinical trial, 100 women with HMB were randomly assigned into two groups. The patients in the Golnar group (n=50) took Golnar capsules 500 mg three times a day for the first 7 days of menstrual cycle for three cycles. The placebo group (n=50), took placebo capsules in the same manner. The duration and volume of bleeding (using Pictorial Blood Loss Assessment Chart: PBAC), quality of life (using Menorrhagia Questionnaire: MQ), and hemoglobin level (Hb) were measured 3 months after initiation of the intervention. Results: Eighty-two patients (43 in the Golnar and 39 in the placebo groups) completed the 3-month intervention period. In the Golnar group, PBAC score decreased from 201.62 (144.11) to 109.44 (69.57) (p<0.001) and MQ score improved significantly from 0.58 (0.27) to 0.39 (0.31) (p<0.001), while changes in placebo group were not significant. Hb increased in the Golnar group from 12.78±0.98 to 12.97±0.95 mg/dl (p=0.048) and decreased in the placebo group from 12.94±1.08 to 12.44±1.01mg/dl (p<0.001). No significant adverse effects were found in the Golnar group. Conclusion: The Golnar product can be considered an effective intervention for patients with HMB. Assessment of side-effects is suggested to be performed in a larger sample. In addition, a comparison between the Golnar product and nonsteroidal anti-inflammatory drugs could be valuable.
      PubDate: Mon, 31 Aug 2020 19:30:00 +010
       
  • Anticancer activity of Astragalus ovinus against 7, 12 dimethyl benz (a)
           anthracene ...

    • Abstract: Objective: Some species of Astragalus are used for the treatment of various types of cancer. The present study was designed to evaluate the anticancer potential of Astragalus ovinus extract (AOE) against DMBA-induced breast carcinoma in rats. Materials and Methods: The anti-tumor and antioxidant effects of AOE were evaluated against DMBA-induced breast carcinoma in rats using DPPH, FRAP and ABTS technique, respectively. Forty adult female Sprague-Dawley rats were randomly divided into four groups including the control group received a single dose of DMBA solvent orally, and groups II, III and IV received a single dose of DMBA (40 mg/kg) dissolved in olive oil. Groups I and II received normal saline and groups III and IV were treated with AOE orally (120 and 240 mg/kg respectively) for 60 consecutive days. Chemopreventive effects were assessed in terms of diameter and volume of tumors, expression levels of PCNA, and serum levels of CA15.3, p53, MDA, CAT, and calcium, and histopathological features Results: AOE contained a noticeable amount of phenolic and flavonoids compounds. This extract showed a potent antioxidant activity both in vitro and in vivo. AOE significantly decreased the diameter and volume of tumors (p<0.01) and reduced the serum levels of CA15.3 (p<0.001), p53 (p<0.01), MDA (p<0.001), and calcium (p<0.01). AOE also decreased the expression of PCNA in cancerous tissues and reduced the histopathological deformity. Conclusion: According to the data, AOE produced a significant chemopreventive activity in DMBA-induced breast tumors in rats, probably due to its antioxidant and its inhibitory effect on some tumorigenicity markers such as CA15.3, p53 and PCNA activity.
      PubDate: Mon, 31 Aug 2020 19:30:00 +010
       
  • Protective effect of Artemisia absinthium on 6-hydroxydopamine-induced
           toxicity in SH-SY5Y cell line

    • Abstract: Objective: Parkinson’s disease (PD) is a neurodegenerative disorder characterized by loss of dopaminergic neurons. Several experimental studies have shown neuroprotective and antioxidant effects for Artemisia absinthium. The present study was designed to assess the effect of A. absinthium on 6-hydroxydopamine (6-OHDA)-induced toxicity in SH-SY5Y cells.Materials and Methods: SH-SY5Y cells were treated with ethanolic extract of A. absinthium for 24 hr and then, exposed to 6-OHDA (250 μM) for another 24 hr. MTT (3-(4, 5-dimethylthiazol- 2-yl)-2, 5-diphenyl tetrazolium bromide) assay was used for evaluation of cell viability. Moreover, the rate of apoptosis was measured using propidium iodide (PI) staining. The amount of intracellular reactive oxygen species (ROS) and malondialdehyde (MDA) was also measured using 2’, 7’–dichlorofluorescin diacetate (DCFDA) fluorometric method. Determination of glutathione (GSH) and superoxide dismutase (SOD) activity was done by colorimetric assay using DTNB [5,5′-Dithiobis(2-nitrobenzoic acid)] and pyrogallol respectively.Results: While 6-OHDA significantly increased ROS and apoptosis (p<0.001), the extract of A. absinthium significantly reduced ROS and cell apoptosis at concentrations ranging from 6.25 to 25 μg/mL (p<0.01 and p<0.001 respectively). Also, the extractsignificantly reduced MDA level in comparison with 6-OHDA (p<0.001). The GSH level and SOD activity were increased by the extract.Conclusion: Findings of the current study showed that A. absinthium exerts it effect throughinhibiting oxidative stress parameters and it can be considered a promising candidate to be used in combination with the conventional medications for the treatment of neurodegenerative disorders, such as Parkinson's disease.
      PubDate: Sun, 23 Aug 2020 19:30:00 +010
       
  • Does curcumin have an effect on sleep duration in metabolic syndrome
           patients'

    • Abstract: Objective: Sleep-duration is related to obesity. Curcumin can affect behavioral changes that arise from sleep deprivation in animal models. In this study, we assessed the effects of curcumin on sleep-duration in metabolic-syndrome (MetS) patients.Materials and Methods: This study was a double-blind clinical trial in 120 adults with MetS. All participants received crude curcuminoids in a simple formulation (n=40), phospholipidated curcuminoids (n=40) or placebo (n=40) 1 g/day during 6 weeks. Demographic data, anthropometric indices and serumbiochemical factors were documented forall volunteers at baseline and after the intervention. A standard questionnaire was used for evaluating physical-activity-level (PAL) and patients’ sleep-duration, including night time sleep and daily napping. Based on the time of sleep, sleeping hours were classified into: night time sleep; daily naps and total sleeping hours in 24 hours.Results: A total of 120 participants aged 38.72±10.05 years old were enrolled into the study. We did not find significant differences in biochemical factors, sleep-duration or PAL at baseline among the 3 groups (p>0·05). Moreover,curcumin did not exert any significant effect on sleep-duration before, or after, adjustment for confounding factors in the overweight and obese individuals, or in total population (p>0.05).Conclusion: The results showed that curcumin does not have an effect on sleep-duration in subject with MetS.
      PubDate: Mon, 10 Aug 2020 19:30:00 +010
       
  • An investigation of the effect of purslane (Portulaca oleracea L. ...

    • Abstract: Objective: Portulaca oleracea L. (PO) is abundantly found in Iran and is used in both nutritional and traditional medicine. Delaying thirst is one of the uses of the medicinal product of this plant which has been emphasized in Iranian traditional medicine though it was not proven scientifically. Accordingly, the present study aimed to investigate the effect ofPO product on thirst.Materials and Methods: In this research, two main Set of experiments were considered: acute water deprivation group and chronic water restriction group. The urine parameters analyzed were osmolality, and sodium, and potassium concentration, and blood parameters evaluated included blood urea nitrogen, creatinine, osmolality, and sodium, and potassium concentration. The PO dosages were 50, 100 and 200 mg/kg.Results: The findings showed that the effects of PO 100 and 200 (mg/kg) on blood and urine parameters were greater than that of PO 50 mg/kg, but there were no significant differences between them.Conclusion: In general, these findings indicate that PO extract can play an important role in reducing thirst symptoms most likely by affecting intra- and extra-cellular environments. Also, it is recommended to study the beneficial effects of this plant on diseases that lead to hypokalemia or blood potassium depletion. 
      PubDate: Mon, 27 Jul 2020 19:30:00 +010
       
  • Evaluation of the effects of additional therapy with Berberis vulgaris
           oxymel in patients with ...

    • Abstract: Objective: There are several studies reporting the therapeutic effects of Berberis vulgaris on liver diseases. This study was done with the purpose of examining the effect of B. vulgaris oxymel (BO) in patients with refractory primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC), who did not respond to current treatment.Materials and Methods: Patients with PSC or PBC who were receiving ursodeoxycholic acid (UDCA, 13-15 mg/kg/day) for at least six months, but their serum levels of alkaline phosphatase (ALP) were still 1.5 folds higher than the normal upper limit during the last six months, were asked to participate in this quasi-experimental study. Patients were asked to take 0.5 ml/kg/day of BOtwo times a day for three months along with UDCA. At the end of the study, serum levels of ALP, aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT), total bilirubin (TB), direct bilirubin (DB), and creatinine as well as prothrombin time (PT), international normalized ratio (INR) and quality of life  (QOL) based on PBC-40 questionnaire were assessed as outcomes.Results: Our results showed that BO notably attenuated the serum levels of ALP, AST, ALT, GGT, TB, and DB, as well as PT and INR and significantly improved QOL. Conclusion: For first time, we showed that additional therapy with BOhas a promising effect in the treatment of refractory PSC and PBC.
      PubDate: Mon, 27 Jul 2020 19:30:00 +010
       
  • The effects of pre-treatment with olibanum and its constituent, boswellic
           acid on synaptic ...

    • Abstract: Objective: Olibanum (OLIB) and its component boswellic acid (BOSA) are suggested to have anti-inflammatory, anti-oxidant and neuroprotective effects. In the present work, we examined effect of OLIB, and BOSA on the synaptic plasticity impairment and oxidative stress indicators in a rat model of neuro-inflammation induced by lipopolysaccharide (LPS).Materials and Methods: Forty rats were divided into the following four groups: (1) Control, (2) LPS, (3) OLIB (200 mg/kg), and (4) BOSA (10 mg/kg). The animals were pre-treated with OLIB extract, BOSA or the vehicle 30 min before LPS (1 mg/kg) administration, for 6 days. On the 6th day, electrophysiological recording was done. Long-term potentiation (LTP) from CA1 area of hippocampus was assessed. The animals were then sacrificed and their brains were removed for evaluation of the levels of interleukin-6 (IL-6), nitric oxide (NO) metabolites, malondialdehyde (MDA), thiol, superoxide dismutase (SOD) and catalase (CAT) in the cortex.Results: Administration of LPS decreased amplitude (p<0.001) and slope (p<0.01) of field excitatory postsynaptic potential (fEPSP). Pre-treatment enhanced these parameters (p<0.05 to p<0.001). LPS also increased cortical levels of IL-6 (P<0.01), NO, and MDA (p<0.001) while decreased thiol, SOD (p<0.001), and CAT (p<0.05). OLIB and BOSA diminished IL-6 (p<0.05-p<0.001), NO (p<0.01-p<0.001) and MDA level (p<0.01 and p<0.001, respectively) while improved SOD (p<0.05 and p<0.001, respectively), CAT (p<0.05 and p<0.001, respectively) and thiol content (p<0.001).Conclusion: The results showed that OLIB and BOSA could improve synaptic plasticity impairment induced by LPS as shown by a decrease in an inflammation indicator along with the anti-oxidant effects. 
      PubDate: Sat, 11 Jul 2020 19:30:00 +010
       
  • Cinnamon effects on blood pressure and metabolic profile: A double-blind,
           randomized, ...

    • Abstract: Objective: Cinnamon effect on blood pressure remains controversial. The present pilot study assessed cinnamon effect on blood pressure, and metabolic profile of stage 1 hypertension patients (S1HTN).Materials and Methods: This double-blind placebo-controlled randomized trial was conducted between June and October 2019, in Mashhad, Iran. Study inclusion criteria comprised S1HTN diagnosis, based on 24-hour ambulatory blood pressure monitoring (ABPM). Subjects were randomly assigned to two groups: cinnamon group (capsule, 1500 mg/day, 90 days) and placebo group. On days 0 and 90, ABPM derived systolic and diastolic blood pressure (SBP and DBP, respectively), blood lipid profile, and fasting blood sugar (FBS) were recorded.Results: The two groups did not differ significantly regarding vascular risk factors, educational status, lipid profile and blood pressure at baseline, except for lower HDL-c in cinnamon group (p=0.03). On day 90, there was no significant difference between two study groups for lipid profile and blood pressure. A statistically significant decrease in mean 24-hr SBP and mean day SBP was observed in the cinnamon group, while mean night SBP and mean night DBP were decreased significantly in the placebo group after 90 days. A statistically significant decrease in mean change of day value of SBP was found in the cinnamon group, compared to the placebo. On day 90, FBS remained practically unchanged but a significant increase in HDL-c (5.8 unit; p=0.01) and a significant decrease in LDL-c levels (17.7 unit; p=0.009) were observed in the cinnamon group compared to placebo group. Conclusion: Cinnamon caused a statistically significant decrease in mean ambulatory SBP but in a clinically moderate way, and lipid profile was significantly improved. Therefore, cinnamon might be considered a complementary treatment in subjects with S1HTN.
      PubDate: Fri, 10 Jul 2020 19:30:00 +010
       
  • New cytotoxic compounds from the leaves of Caesalpinia benthamiana
           (Baill.) Herend. ...

    • Abstract: Objective: The incidence of multi-drug resistant cancer and the adverse effects associated with available chemotherapy have necessitated the search for new drug candidates. This study investigates the cytotoxic activity of Caesalpinia benthamiana.Materials and Methods: Column chromatography (CC) and preparative thin layer chromatography (PTLC) were used to isolate compounds. Structural elucidation was done by spectroscopic analysis. MTT assay was used to evaluate cytotoxicity of the compounds against three human adenocarcinoma cells, using methotrexate and dimethyl sulfoxide (DMSO) as positive and negative controls, respectively. CyQuant direct cell proliferation and caspase-3/7 green detection assays were used to investigate the dichloromethane fraction. IC50 values of isolated compounds were determined from sigmoidal dose-response curve.Results: Four new cytotoxic compounds, benthamianoate (2), benthamiacone (3), benthamianin (5) and benthamianol (6), and two known compounds, methyl gallate (1) and 2-methoxyacrylic acid (4) were identified. All the compounds were active with the new monoterpenoid characterized as benthamiacone exhibiting the highest activity (IC50 13.23-21.97 μg/ml) across cancer cell lines investigated. CyQuant direct cell proliferation assay showed significant reduction in the number of live carcinoma cells, while caspase-3/7 green detection assay showed significant increase in the number of dead carcinoma cells.Conclusion: This study revealed potential cytotoxic compounds which are here reported for the first time from C. benthamiana.
      PubDate: Sat, 27 Jun 2020 19:30:00 +010
       
  • Hepatoprotective properties of p-coumaric acid in a rat model of
           ischemia-reperfusion

    • Abstract: Objective: The liver as a highly metabolic organ, has a crucial role in human body. Its function is often impressed by changes of the blood flow, hypovolemic shock, transplantation, etc. Maintaining liver function is a major challenge and there are many approaches to potentiate this organ against different stresses. Antioxidants protect organs against oxidative stress. P-coumaric acid (PC) as an oxidant has many beneficial effects. Therefore, PC was used as a pretreatment to test its potential against oxidative stress induced by liver Ischemia-reperfusion injury in rats.  Materials and Methods: In order to test the potential hepatoprotective effect of PC against IR injury, five groups of rats were used: Normal (NC; intact group); Sham; p-coumaric acid (PC); IR-CO, and PC-IR. PC, Sham, NC, PC-IR and IR-CO groups that received vehicle or p-coumaric acid at a dose of 100 mg/kg for 7 consecutive days as pretreatment before IR induction. Animals in PC-IR, and IR-CO groups underwent hepatic IR injury. Liver levels of antioxidants were determined and functional liver tests were done. Hematoxylin and eosin staining was done to determine the structural changes of the liver. Gene expression of caspase-3 was also assessed.  Results: Hepatic IR injury disrupted liver function by increasing the levels of AST, and ALT, and decreasing GSH, SOD and catalase. PC significantly decreased liver inflammation, reverted liver functional enzymes and antioxidants levels to normal, reduced the gene expression of caspase-3 in PC-IR rats compared to the IR-CO group. Conclusion: These findings revealed that PC through improving liver´s antioxidants, liver functional tests and down-regulating apoptotic gene protein, caspase-3, protects the liver against injury induced by IR. 
      PubDate: Tue, 23 Jun 2020 19:30:00 +010
       
  • The Protective Role of Kombucha Extract on Normal Intestinal
           Microflora,High-Cholesterol ...

    • Abstract: Objective: The aim of the current study was to investigate the effect of Kombucha extract (tea) on the normal intestinal microflora and histological structures in rabbits.Materials and Methods: This study was a descriptive-analytical investigation. Thirty-two male New Zealand rabbits were randomly divided into 4 groups as follows: Normal diet (I), high-cholesterol diet (II), normal diet plus Kombucha extract (II), and high-cholesterol diet plus Kombucha extract (IV). Microbial cultures were taken from feces of rabbits before and after the applied treatments. The rabbits' blood was collected from the heart to determine the level of cholesterol, glucose and iron in the blood. Aorta and coronary heart microtome cut samples were prepared for detection of histological changes.Results: Rabbit stool cultures before treatment with Kombucha extract included Enterobacter aerogenes, Providencia rettgeri, Proteus mirabilis, Pseudomonas aeruginosa and Klebsiella oxytoca. However, Escherichia coli, Enterobacter aerogenes, Pseudomonas aeruginosa, klebsiella pneumoniae and Hafnia alvei were found in stool cultures after treatment with Kombucha extract. Group IV had significantly lower blood cholesterol levels. Animals that received Kombucha extract only had lower fasting blood sugar (FBS) levels. Healthy rabbits that received Kombucha extract only and group (IV) showed a significant increase in iron (Fe) levels and a significant decrease in total iron binding capacity (TIBC) levels. In both groups III and IV, the right and left coronary arteries were completely normal and no lesions were observed in the intima.Conclusion: The results of this study showed minor changes in the intestinal microflora of rabbits after treatment with Kombucha extract and positive effects of this tea on some risk factors (hypercholesterolemia, arteriosclerosis, and FBS).
      PubDate: Tue, 23 Jun 2020 19:30:00 +010
       
  • Evaluation of anticancer, antioxidant and antibacterial properties of
           methanol extract of three ...

    • Abstract: Objective: Acantholimon is a genus of perennial plant within the Plumbaginaceae family. Here, we aimed to investigate anticancer, antioxidant, and antibacterial potential of methanol extract of three Iranian endemic species of Acantholimon including A. austro-iranicum, A. serotinum and A. chlorostegium. Materials and Methods: MTT assay was used to evaluate the in vitro cytotoxicity and apoptosis induction was examined by annexin V-PE apoptosis detection kit. Antioxidant activity was reported based on the DPPH-scavenging and DCF-DA assay. Antibacterial activity was measured by disc diffusion and micro-well dilution assay.Results: MTT assay showed less cytotoxicity of methanol extracts against the HUVEC normal cell line (IC50 values: 817-900 µg/ml) compared to cancer cell lines MCF-7, HT29, SH-SY5Y, NCCIT and A549 (IC50 values: 213 to 600 µg/ml) that show the specificity of extracts toward cancer cells. Plant extract showed apoptosis induction and cell cycle arrest at the G0/G1 phases documented by annexin V staining and flow cytometry. According to antioxidant tests, extracts exhibited significant DPPH scavenging potential (IC50 values: 30-37 µg/ml) and could protect against H2O2-induced oxidative stress. Antibacterial activities showed a stronger inhibitory effect on Escherichia coli and Pseudomonas aeruginosa as Gram- negative bacteria (diameter of inhibition zone: 11-13 mm and minimal inhibition concentration (MIC): 3.175 to 12.5 mg/ml) compared to Gram-positive bacteria including Enterococcus faecalis and Staphylococcus aureus (diameter of inhibition zone: 3-7 mm and MIC: 25 to 50 mg/ml).Conclusion: Our results suggested moderate cytotoxic and antibacterial potential and noteworthy antioxidant activity for the examined Acantholimon species.
      PubDate: Sun, 07 Jun 2020 19:30:00 +010
       
  • Effect of Propolis on moderate persistent asthma: A phase two randomized,
           double blind, ...

    • Abstract: Objective: The aims of this study was to determine the effect of Propolis (resinous mixture that honey bees produce by mixing saliva and beeswax) on clinical and physiological findings of moderate persistent asthma.Materials and Methods: Fifty-two subjects aged 44.6±18.5 years old with moderate asthma and Forced expiratory volume in 1 second (FEV1) 60-79% of predicted, were enrolled in this clinical trial. We randomly allocated subjects to receive either propolis (75 mg three times a day) or a matched placebo for one month. Primary outcome was Asthma control test (ACT) score and secondary outcomes included dyspnea, spirometry, fractional exhaled nitric oxide (FENO) and sputum cytology including inflammatory cell. Sputum induction was done by hypertonic saline and cytology slides were stained by Papanicolaou stain.Results: Clinical findings significantly improved after the treatment. ACT scores significantly increased by using propolis (12.8±5.5 before and 18.1±4.99 after the trial), which was significantly higher than the placebo group (14.4±6.6 after the trial). The most significant physiological improvements were significant increases in FEV1, FV1/Forced vital capacity and expiratory flows. FENO showed significant decreases in the propolis group but increases in the placebo group. Cytological examination of sputum showed that the pattern of inflammation was eosinophilic in 44% subjects with an average eosinophil of 7.2±1.01%. Eosinophilia significantly decreased (p<0.05) by using propolis (7.2±1.01 and 4.3±3.1%, before and after treatment, respectively), but it significantly increased (p<0.04) in the placebo group (5.5±2.8, and 11.1±6.6%, before and after treatment, respectively).Conclusion: Propolis improved the clinical and physiological findings of moderate persistent asthma, and it was able to suppress eosinophilic inflammation.
      PubDate: Mon, 01 Jun 2020 19:30:00 +010
       
  • The vasodilatory effect of Apium graveolens L (celery) seed in isolated
           rat aorta: The roles of ...

    • Abstract: AbstractObjective: Apium graveolens L. (celery) seed has been used for hypertension treatment. To provide a pharmacological basis, the vasorelaxant effect of celery seed extract was investigated in isolated rat aorta.Materials and Methods: Wistar male rats (200-250 g) were divided into 15 groups (n=7 for each group). The vasorelaxant response of different concentrations of celery seed extract (0.05, 0.1, 0.25, 0.5, 1, and 2 mg/ml) on isolated aorta precontracted with phenylephrine (PE) or KCl was evaluated by organ bath technique. The role of endothelium, extracellular calcium influx, intracellular sources of calcium, and potassium channels in vasorelaxant effect of celery seed extract was investigated. Results: The extract showed a concentration-dependent relaxation in the isolated aorta contracted with PE and KCl that was endothelium-dependent at lower concentrations. Pretreatment of aortic rings with indomethacin or L-NAME, did not affect the vasorelaxation induced by celery seed extract. The extract inhibited KCl and PE-induced contractions in cumulative calcium concentrations as well as after incubation with diltiazem in denuded aortic rings of endothelium. The relaxation induced by celery seed extract was inhibited by 4-aminopyridine.Conclusion: This relaxation was mediated by inhibiting calcium influx into vascular smooth muscle cells. Also, voltage-dependent potassium channels were involved in inducing the vasorelaxant effect of celery seed extract.
      PubDate: Fri, 29 May 2020 19:30:00 +010
       
  • In vitro and in vivo activity of the essential oil and nanoemulsion of
           Cymbopogon flexuosus ...

    • Abstract: Objective: This study was done to evaluate the in vitro and in vivo effects of the essential oil (OE-CL) and nanoemulsion (N-CL) of Cymbopogon flexuosus against Trichomonas gallinae.Materials and Methods: In vitro assays were done with 106 parasites and OE-CL and N-CL in the concentrations: 110, 220, 330, 440, 550, 660, 770 and 880 µg/ml and four controls: CN (culture medium and trophozoites), MTZ (trophozoites plus 800 µg/ml of metronidazole), TW (trophozoites plus vehicles used for solubilization of derivatives (0.01% Tween) and NB (blank nanoemulsion 880 µg/ml). The in vivo assay was done in 35 quails (Coturnix coturnix) infected experimentally 4x104 mg/kg,  were divided in   seven groups (n=5): A (control–healthy), B (control infected), C (control TW 0.01%), D (NB 0.88 mg/kg), E (drug MTZ 25 mg/kg, F (OE-CL at 0.55 mg/kg ) and G (N-CL at 0.44 mg/kg), during 7 consecutive days.Results: The in vitro test showed that the OE-CL (550 μg/ml) and N-CL (440 μg/ml) concentrations reduced the trophozoites viability in 100%. In the in vivo test, the treatment with OE-CL was efficient on the 4th treatment day and the N-CL after the 3rd day, and the MTZ in the therapeutic concentration was efficient on the 7th day.Conclusion: It can be observed in this study that the lemon grass has natural potential antitrichomonal activity against T. gallinae in vitro and in vivo.
      PubDate: Sun, 17 May 2020 19:30:00 +010
       
  • Protective impact of Rosa damascena against neural damage in a rat model
           of pentylenetetrazole ...

    • Abstract: Objective: Based on the previously-declared anticonvulsant properties of Rosa damascena (R. damascena), this study explored the probable effects of R. damascena on neuronal apoptosis in the hippocampus of a rat model of pentylenetetrazole (PTZ)-induced seizure.Materials and Methods: 40 male Wistar rats were randomely divided into control (n=8) and experimental (n=32) groups which underwent PTZ injection. A one-week pre-medication with 50 (PTZ-Ext 50) (n=8), 100 (PTZ-Ext 100) (n=8), and 200 (PTZ-Ext 200) (n=8) mg/kg of hydro-alcoholic extract of R. Damascene was performed while one experimental group (PTZ-induced group) (n=8) received only saline during the week before PTZ injection. After provocation of PTZ-induced seizures, the brains underwent tissue processing and TUNEL staining assay for apoptotic cell quantification.Results: Our findings revealed that PTZ-induced seizures led to apoptosis in neuronal cells of all sub-regions of the hippocampus; yet, only at CA1, CA3 and DG sub-regions of the PTZ-induced group, the difference in the number of apoptotic neuronal cells was significant in comparison with the control group. In addition, pre-medication with the plant extract led to a significant drop in the quantity of apoptotic neurons in these sub-regions in comparison with the PTZ-induced group which received no pre-medication .Conclusion: The results of this study showed that R. damascena extract exerts neuro-protective effects on PTZ-induced seizure.
      PubDate: Wed, 13 May 2020 19:30:00 +010
       
  • Phytochemical, anti-inflammatory and analgesic properties of stembark
           extract and fractions of ...

    • Abstract: Objective: Lonchocarpus sericeusstembark decoction has been extensively employed in folkloric medicine in many parts of Nigeria as a remedy for pain as well as inflammation. The plant was studied for its anti-inflammatory as well as analgesic potency using standard biological models.Materials and Methods: The stembark of L. sericeus was evaluated for anti-inflammatory properties using egg albumin and xylene-induced oedema models. The pain-relieving property was evaluated using acetic acid-induced writhing and thermally-induced pain models. Median lethal dose determination (intraperitoneal LD50), quantification of some phytochemicals as well as phytochemical screening were also performed.Results: The LD50 of stembark extract of L. sericeus was found to be 3,100 mg/kg (i. p). The crude extract and fractions (310-930 mg/kg) effectively reduced oedema caused by egg albumin and xylene and exhibited high analgesic properties in inhibiting pain induced by acetic acid and heat. These reductions were dose-dependent and statistically significant (p<0.05-0.001) when compared to distilled water and similar to prototype drugs employed. Quantitative determinations of some bio-active constituents of the plant showed a higher flavonoid content (0.52±0.02 mg/100 g) compared to alkaloids (0.36±0.02 mg/100 g) and flavonoids (0.49±0.03 mg/100 g). Phytochemical screening of the stembark showed the presence of alkaloids, cardiac glycosides, flavonoids terpenes, tannins and saponins.Conclusion: These  results  imply  that  the stembark  extract  of L. sericeus  possesses anti-inflammatory  and analgesic potency and these data validate its  wide use  in folkloric medicine for inflammation and pain management.
      PubDate: Wed, 13 May 2020 19:30:00 +010
       
  • Cytotoxic and apoptogenic effects of Dracocephalum kotschyi Boiss. ...

    • Abstract: Objective: Glioblastoma multiforme (GBM) is the most aggressive and malignant brain tumor and has a poor prognosis. This study was aimed to investigate the cytotoxic effects of Dracocephalum kotschyi Boiss. (D. kotschyi) extracts in GBM U87 cell line.Materials and Methods: The extracts of D. kotschyi obtained by two different ways of Soxhlet and soaked. The cytotoxic effects of D. kotschyi extracts were measured using MTT assay following treatment for different times of exposure (24, 48, and 72 hr) and at different concentrations of D. kotschyi extracts. The effects of D. kotschyi extracts on cellular oxidative stress were also evaluated by measuring cellular ROS levels. Furthermore, cellular death and apoptosis were studied by sub G1 analysis and Annexin V-FITC/propidium iodide (PI) staining using flow cytometry method, respectively. Characterization of the extracts was carried out using gas chromatography/mass spectrometry (GC/MS) analysis by Agilent GC-MSD system.Results: Our results indicated thatD. kotschyi extracts decreased U87 cell viability in a time- and dose-dependent manner. Moreover, treatment with D. kotschyi extracted by Soxhlet for 24 and 48 hr significantly increased the levels of cellular ROS and Sub G1 population (p<0.001-0.05 for all cases). Furthermore, GC/MS analysis revealed that essential oils of D. kotschyi mainly consisted of β-caryophellene, α-pinene and limonene.Conclusion: Our findings demonstrated that D. kotschyi extracts can exert cytotoxic effects against GBM U87 cell line in a time- and concentration-dependent manner, and these effects may be mediated through intracellular ROS accumulating. However, further studies should be performed to confirm the efficacy and exact mechanism of action of the extracts.
      PubDate: Wed, 13 May 2020 19:30:00 +010
       
  • The role of resveratrol as a natural modulator in glia activation in
           experimental models of stroke

    • Abstract: Objective: Stroke is one of the most important causes of death and disability in modern and developing societies. In a stroke, both the glial cells and neurons develop apoptosis due to decreased cellular access to glucose and oxygen. Resveratrol (3, 5, 4′-trihydroxy-trans-stilbene) as a herbal compound shows neuroprotective and glioprotective effects. This article reviews how resveratrol can alleviate symptoms after stroke to help neurons to survive by modulating some signaling pathways in glia.Materials and Methods: Various databases such as ISI Web of Knowledge, Scopus, Medline, PubMed, and Google Scholar, were searched from 2000 to February 2020 to gather the required articles using appropriate keywords.Results: Resveratrol enhances anti-inflammatory and decreases inflammatory cytokines by affecting the signaling pathways in microglia such as AMP-activated protein kinase (5' adenosine monophosphate-activated protein kinase, AMPK), SIRT1 (sirtuin 1) and SOCS1 (suppressor of cytokine signaling 1). Furthermore, through miR-155 overexpressing in microglia, resveratrol promotes M2 phenotype polarization. Resveratrol also increases AMPK and inhibits GSK-3β (glycogen synthase kinase 3 beta) activity in astrocytes, which release energy, makes ATP available to neurons and reduces reactive oxygen species (ROS). Besides, resveratrol increases oligodendrocyte survival, which can lead to maintaining post-stroke brain homeostasis.Conclusion: These results suggest that resveratrol can be considered a novel therapeutic agent for the reduction of stroke symptoms that can not only affect neuronal function but also play an important role in reducing neurotoxicity by altering glial activity and signaling.
      PubDate: Sun, 26 Apr 2020 19:30:00 +010
       
  • Glucose-lowering potential of Guiera senegalensis roots in a diabetic rat
           model

    • Abstract: Objective: Guiera senegalensis is distributed in the Sudano-Sahelian zone and used traditionally for the treatment of diabetes. This study was designed to assess the hypoglycemic effects of G. senegalensis in Wistar diabetic rats.Materials and Methods: Phytochemical analysis was carried out on aqueous and methanolic extracts of G. senegalensis. Type 2 diabetes was induced in male rats using nicotinamide/streptozotocin (65 mg/kg/110 mg/kg, i.p.). After diabetes induction, normal and negative control groups received distilled water, positive control group received glibenclamide (0.25 mg/kg) and the others group received aqueous and methanolic extracts (200 and 400 mg/kg, each) orally for 4 weeks. Glycaemia, body weight, insulin level, total cholesterol (TC), high density lipoprotein cholesterol (HDL-c), low density lipoprotein cholesterol (LDL-c), triglycerides (TG), aspartate amino transferase (AST) and alanine amino transferase (ALT) activities, urea and creatinine (Cr) were evaluated. Results: The content of phenols, flavonoids and tannins were 34.54 mg gallic acid equivalent (GAE)/gE, 4.86 mg quercetin equivalent (QE)/gE and 16.81 mg catechin equivalent (EC)/gE in the aqueous extract, respectively. Phenol (26.01 mg GAE/gE), flavonoid (4.47 mg QE/gE) and tannin (7.67 mg EC/gE) contents were also obtained for the methanolic extract.  G. senegalensis and glibenclamide resulted in a significant increase (p<0.001) in body weight and HDL-c in diabetic group rats receiving glibenclamide and different doses of extracts. . The level of insulin, glycaemia, TG, TC, LDL-c, urea and creatinine significantly decreased (p<0.05 to 0.001) in diabetic animals treated with G. senegalensis extracts.Conclusion: These results confirm the potential of G. senegalensis for the treatment of diabetes and its complications.
      PubDate: Mon, 20 Jan 2020 20:30:00 +010
       
 
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