Subjects -> FOOD AND FOOD INDUSTRIES (Total: 387 journals)
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    - FOOD AND FOOD INDUSTRIES (273 journals)

FOOD AND FOOD INDUSTRIES (273 journals)                  1 2     

Showing 1 - 62 of 62 Journals sorted alphabetically
Acta Alimentaria     Full-text available via subscription   (Followers: 7)
Acta Universitatis Cibiniensis. Series E: Food Technology     Open Access   (Followers: 2)
Acta Universitatis Sapientiae, Alimentaria     Open Access   (Followers: 1)
adhäsion KLEBEN & DICHTEN     Hybrid Journal   (Followers: 9)
Advances in Food and Nutrition Research     Full-text available via subscription   (Followers: 68)
Advances in Nutrition     Hybrid Journal   (Followers: 57)
African Journal of Drug and Alcohol Studies     Full-text available via subscription   (Followers: 6)
African Journal of Food Science     Open Access   (Followers: 9)
African Journal of Food, Agriculture, Nutrition and Development     Open Access   (Followers: 23)
Agricultural and Food Science     Open Access   (Followers: 22)
Agriculture & Food Security     Open Access   (Followers: 16)
Agriculture and Food Sciences Research     Open Access   (Followers: 11)
Agro-Science     Full-text available via subscription   (Followers: 2)
Agroecology and Sustainable Food Systems     Hybrid Journal   (Followers: 18)
Agrosearch     Open Access   (Followers: 2)
Alimentos e Nutrição     Open Access   (Followers: 1)
Alimentos Hoy     Open Access   (Followers: 1)
American Journal of Food and Nutrition     Open Access   (Followers: 55)
American Journal of Food Science and Technology     Open Access   (Followers: 11)
American Journal of Food Technology     Open Access   (Followers: 9)
Amerta Nutrition     Open Access  
Amino Acids     Hybrid Journal   (Followers: 7)
Animal Production     Open Access   (Followers: 5)
Animal Production Science     Hybrid Journal   (Followers: 2)
Annual Review of Food Science and Technology     Full-text available via subscription   (Followers: 15)
Anthropology of food     Open Access   (Followers: 14)
Applied Food Biotechnology     Open Access   (Followers: 4)
Arquivos Brasileiros de Alimentação     Open Access  
Asian Food Science Journal     Open Access   (Followers: 1)
Asian Journal of Animal and Veterinary Advances     Open Access   (Followers: 8)
Asian Journal of Cell Biology     Open Access   (Followers: 6)
Asian Journal of Clinical Nutrition     Open Access   (Followers: 14)
Asian Journal of Crop Science     Open Access   (Followers: 3)
Asian Plant Research Journal     Open Access  
Bangladesh Rice Journal     Open Access   (Followers: 2)
Biotechnology and Genetic Engineering Reviews     Hybrid Journal   (Followers: 12)
Boletim de Indústria Animal     Open Access  
Brazilian Journal of Food Technology     Open Access   (Followers: 3)
Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca : Food Science and Technology     Open Access  
Canadian Food Studies / La Revue canadienne des études sur l'alimentation     Open Access  
Cerâmica     Open Access   (Followers: 5)
Chemical Research in Chinese Universities     Hybrid Journal   (Followers: 3)
Ciência e Agrotecnologia     Open Access  
COCOS : The Journal of the Coconut Research Institute of Sri Lanka     Open Access   (Followers: 1)
Cogent Food & Agriculture     Open Access   (Followers: 3)
Comprehensive Reviews in Food Science and Food Safety     Hybrid Journal   (Followers: 7)
Critical Reviews in Food Science and Nutrition     Hybrid Journal   (Followers: 31)
Cuizine: The Journal of Canadian Food Cultures / Cuizine : revue des cultures culinaires au Canada     Open Access   (Followers: 3)
Culture, Agriculture, Food and Environment     Hybrid Journal   (Followers: 16)
Culture, Agriculture, Food and Environment     Hybrid Journal   (Followers: 8)
Current Botany     Open Access   (Followers: 1)
Current Opinion in Food Science     Hybrid Journal   (Followers: 6)
Current Research in Dairy Sciences     Open Access   (Followers: 6)
Current Research in Microbiology     Open Access   (Followers: 25)
Current Research in Nutrition and Food Science     Open Access   (Followers: 5)
CyTA - Journal of Food     Open Access   (Followers: 1)
Detection     Open Access   (Followers: 4)
Developments in Food Science     Full-text available via subscription   (Followers: 2)
EFSA Journal     Open Access   (Followers: 6)
Emirates Journal of Food and Agriculture     Open Access   (Followers: 2)
Engineering in Agriculture, Environment and Food     Hybrid Journal  
Enzyme Research     Open Access   (Followers: 5)
Estudios sociales : Revista de alimentación contemporánea y desarrollo regional     Open Access  
European Food Research and Technology     Hybrid Journal   (Followers: 9)
European Journal of Nutrition & Food Safety     Open Access  
Flavour     Open Access   (Followers: 3)
Flavour and Fragrance Journal     Hybrid Journal   (Followers: 4)
Focusing on Modern Food Industry     Open Access   (Followers: 2)
Food & Function     Full-text available via subscription   (Followers: 9)
Food & Nutrition Research     Open Access   (Followers: 32)
Food Additives & Contaminants Part A     Hybrid Journal   (Followers: 10)
Food Additives and Contaminants: Part B: Surveillance     Hybrid Journal   (Followers: 3)
Food Analytical Methods     Hybrid Journal   (Followers: 3)
Food and Applied Bioscience Journal     Open Access   (Followers: 2)
Food and Bioprocess Technology     Hybrid Journal   (Followers: 4)
Food and Bioproducts Processing     Hybrid Journal   (Followers: 5)
Food and Chemical Toxicology     Hybrid Journal   (Followers: 23)
Food and Energy Security     Open Access   (Followers: 6)
Food and Environment Safety     Open Access   (Followers: 1)
Food and Nutrition Bulletin     Hybrid Journal   (Followers: 6)
Food and Nutrition Sciences     Open Access   (Followers: 15)
Food and Public Health     Open Access   (Followers: 17)
Food and Waterborne Parasitology     Open Access  
Food Biology     Open Access   (Followers: 1)
Food Biophysics     Hybrid Journal   (Followers: 4)
Food Bioscience     Hybrid Journal   (Followers: 2)
Food Biotechnology     Hybrid Journal   (Followers: 8)
Food Chain     Full-text available via subscription   (Followers: 1)
Food Chemistry     Hybrid Journal   (Followers: 22)
Food Chemistry : X     Open Access  
Food Control     Hybrid Journal   (Followers: 10)
Food Digestion     Hybrid Journal   (Followers: 5)
Food Economics     Hybrid Journal   (Followers: 2)
Food Ethics     Hybrid Journal   (Followers: 1)
Food Hydrocolloids     Hybrid Journal   (Followers: 5)
Food In     Open Access  
Food Manufacturing Africa     Full-text available via subscription  
Food Microbiology     Hybrid Journal   (Followers: 21)
Food New Zealand     Full-text available via subscription   (Followers: 4)
Food Packaging and Shelf Life     Hybrid Journal   (Followers: 4)
Food Processing     Full-text available via subscription   (Followers: 7)
Food Quality and Preference     Hybrid Journal   (Followers: 7)
Food Quality and Safety     Open Access   (Followers: 1)
Food Research International     Hybrid Journal   (Followers: 10)
Food Reviews International     Hybrid Journal   (Followers: 4)
Food Science & Nutrition     Open Access   (Followers: 58)
Food Science and Biotechnology     Hybrid Journal   (Followers: 10)
Food Science and Human Wellness     Open Access   (Followers: 5)
Food Science and Quality Management     Open Access   (Followers: 9)
Food Science and Technology     Open Access   (Followers: 3)
Food Science and Technology (Campinas)     Open Access   (Followers: 1)
Food Science and Technology International     Hybrid Journal   (Followers: 6)
Food Security     Open Access   (Followers: 11)
Food Structure     Hybrid Journal   (Followers: 3)
Food Technology     Full-text available via subscription   (Followers: 9)
Food Technology and Biotechnology     Open Access   (Followers: 1)
Foodborne Pathogens and Disease     Hybrid Journal   (Followers: 13)
Foodnews     Partially Free   (Followers: 2)
Foods     Open Access  
Frontiers in Sustainable Food Systems     Open Access  
Future of Food : Journal on Food, Agriculture and Society     Open Access   (Followers: 15)
Gastroia : Journal of Gastronomy And Travel Research     Open Access   (Followers: 1)
Gastronomica     Full-text available via subscription   (Followers: 11)
Gıda Dergisi     Open Access  
Global Food History     Hybrid Journal  
Global Food Security     Hybrid Journal   (Followers: 1)
GM Crops and Food: Biotechnology in Agriculture and the Food Chain     Full-text available via subscription   (Followers: 3)
Grasas y Aceites     Open Access  
Habitat     Open Access  
Harran Tarım ve Gıda Bilimleri Dergisi     Open Access   (Followers: 1)
Indonesian Food and Nutrition Progress     Open Access  
Indonesian Food Science & Technology Journal     Open Access  
INNOTEC : Revista del Laboratorio Tecnológico del Uruguay     Open Access  
Innovative Food Science & Emerging Technologies     Hybrid Journal   (Followers: 5)
International Journal of Agriculture, Environment and Food Sciences     Open Access   (Followers: 2)
International Journal of Dairy Science     Open Access   (Followers: 6)
International Journal of Food Contamination     Open Access  
International Journal of Food Engineering     Hybrid Journal   (Followers: 3)
International Journal of Food Engineering Research     Open Access  
International Journal of Food Microbiology     Hybrid Journal   (Followers: 20)
International Journal of Food Properties     Open Access   (Followers: 2)
International Journal of Food Safety, Nutrition and Public Health     Hybrid Journal   (Followers: 22)
International Journal of Food Science     Open Access   (Followers: 5)
International Journal of Food Science & Technology     Hybrid Journal   (Followers: 7)
International Journal of Food Science and Nutrition Engineering     Open Access   (Followers: 8)
International Journal of Gastronomy and Food Science     Open Access   (Followers: 6)
International Journal of Latest Trends in Agriculture and Food Sciences     Open Access   (Followers: 5)
International Journal of Meat Science     Open Access  
International Journal of Poultry Science     Open Access   (Followers: 6)
International Journal on Food System Dynamics     Open Access  
ISABB Journal of Food and Agricultural Sciences     Open Access   (Followers: 1)
Italian Journal of Food Safety     Open Access   (Followers: 1)
Italian Journal of Food Science     Open Access   (Followers: 3)
itepa : Jurnal Ilmu dan Teknologi Pangan     Open Access  
JOT Journal für Oberflächentechnik     Hybrid Journal   (Followers: 1)
Journal für Verbraucherschutz und Lebensmittelsicherheit     Hybrid Journal  
Journal of Acupuncture and Herbs     Open Access   (Followers: 3)
Journal of Agricultural & Food Industrial Organization     Hybrid Journal  
Journal of Agriculture and Food Sciences     Full-text available via subscription   (Followers: 2)
Journal of Agriculture and Natural Resources     Open Access   (Followers: 1)
Journal of Agriculture, Food Systems, and Community Development     Open Access  
Journal of AOAC International     Full-text available via subscription   (Followers: 8)
Journal of Applied Botany and Food Quality     Open Access   (Followers: 5)
Journal of Aquatic Food Product Technology     Hybrid Journal   (Followers: 4)
Journal of Berry Research     Hybrid Journal   (Followers: 1)
Journal of Culinary Science & Technology     Hybrid Journal   (Followers: 1)
Journal of Environmental Health Science & Engineering     Open Access   (Followers: 1)
Journal of Ethnic Foods     Open Access   (Followers: 1)
Journal of Excipients and Food Chemicals     Open Access   (Followers: 1)
Journal of Fisheries and Aquatic Science     Open Access   (Followers: 6)
Journal of Food and Dairy Technology     Open Access  
Journal of Food and Drug Analysis     Open Access  
Journal of Food and Pharmaceutical Sciences     Open Access   (Followers: 2)
Journal of Food Biochemistry     Hybrid Journal   (Followers: 6)
Journal of Food Chemistry and Nutrition     Open Access   (Followers: 5)
Journal of Food Composition and Analysis     Hybrid Journal   (Followers: 3)
Journal of Food Engineering     Hybrid Journal   (Followers: 6)
Journal of Food Health and Bioenvironmental Science     Open Access  
Journal of Food Lipids     Hybrid Journal  
Journal of Food Measurement and Characterization     Hybrid Journal  
Journal of Food Microbiology     Open Access   (Followers: 9)
Journal of Food Process Engineering     Hybrid Journal   (Followers: 4)
Journal of Food Processing & Technology     Open Access   (Followers: 2)
Journal of Food Processing and Preservation     Hybrid Journal   (Followers: 3)
Journal of Food Products Marketing     Hybrid Journal   (Followers: 2)
Journal of Food Protection(R)     Full-text available via subscription   (Followers: 7)
Journal of Food Quality     Hybrid Journal   (Followers: 8)
Journal of Food Research     Open Access   (Followers: 3)
Journal of Food Safety     Hybrid Journal   (Followers: 14)
Journal of Food Science     Hybrid Journal   (Followers: 12)
Journal of Food Science and Technology     Hybrid Journal   (Followers: 6)
Journal of Food Science and Technology Nepal     Open Access  
Journal of Food Science Education     Hybrid Journal   (Followers: 4)
Journal of Food Security     Open Access   (Followers: 6)
Journal of Food Security and Agriculture     Open Access  
Journal of Food Studies     Open Access   (Followers: 5)
Journal of Food Technology, Siam University     Open Access  
Journal of Foodservice     Hybrid Journal   (Followers: 1)
Journal of Functional Foods     Hybrid Journal   (Followers: 3)
Journal of Gastronomy, Hospitality and Travel     Open Access  

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Similar Journals
Journal Cover
Journal of Functional Foods
Journal Prestige (SJR): 1.245
Citation Impact (citeScore): 4
Number of Followers: 3  
 
  Hybrid Journal Hybrid journal (It can contain Open Access articles)
ISSN (Print) 1756-4646
Published by Elsevier Homepage  [3161 journals]
  • A bio-guided assessment of the anti-inflammatory activity of hop extracts
           (Humulus lupulus L. cv. Cascade) in human gastric epithelial cells
    • Abstract: Publication date: June 2019Source: Journal of Functional Foods, Volume 57Author(s): Enrico Sangiovanni, Marco Fumagalli, Laura Santagostini, Martino Forino, Stefano Piazza, Elisa Colombo, Orazio Taglialatela-Scafati, Gelsomina Fico, Mario Dell'AgliThe present work aims to characterize and investigate the anti-inflammatory activity of hop extracts (cv. Cascade) in an in vitro model of gastric inflammation. The biological activities of hydroalcoholic and aqueous extracts from cones were evaluated by comparing IL-8 inhibition induced by TNFα. The hydroalcoholic extract demonstrated a higher inhibitory effect, which was just slightly affected by an in vitro simulated gastric digestion. The identification of active compounds was performed by a bio-guided fractionation which afforded 11 fractions, one of which inhibited IL-8 release in a concentration-dependent fashion in human gastric epithelial AGS cells. Phytochemical analysis revealed xanthohumol A and xanthohumol D as the main active components. The present study provides some experimental evidences that Humulus lupulus L. may exert an anti-inflammatory activity on the gastric district by the inhibition of the IL-8 secretion, partially due to its prenylated chalcones content.Graphical abstractGraphical abstract for this article
       
  • Cranberry (Vaccinium macrocarpon) peel polyphenol-rich extract attenuates
           rat liver mitochondria impairments in alcoholic steatohepatitis in vivo
           and after oxidative treatment in vitro
    • Abstract: Publication date: June 2019Source: Journal of Functional Foods, Volume 57Author(s): Ilya Zavodnik, Vyacheslav Buko, Oxana Lukivskaya, Elena Lapshina, Tatsiana Ilyich, Elena Belonovskaya, Siarhei Kirko, Elena Naruta, Irina Kuzmitskaya, Grazyna Budryn, Dorota Zyzelevicz, Joanna Orach, Agnieszka Zakrzeska, Lyudmila KiryukhinaAlcoholic steatohepatitis is an important medical problem but its effective therapies are still not available. Plant polyphenols are widely used for prevention of toxic liver damages. The aim of the study was to evaluate the hepatoprotective mechanism(s) of a cranberry peel polyphenol-rich extract, focusing on the effects of the polyphenols on the mitochondrial function.The main components of cranberry peel phenolic compounds were anthocyanins, flavan-3-ols, procyanidins, flavonols, phenolic acids, as was detected using UHPLC-ESI-QTOF-MS. The treatment of rats receiving ethanol (4 g/kg bw, 8 weeks) with cranberry polyphenols (daily, 4 mg/kg bw) partially prevented alcoholic liver damage, ameliorating steatosis and inflammatory signs in the liver, decreasing serum and liver triglyceride contents, ALT and AST activities, as well as diminishing TNFα and TGFβ levels in serum. The polyphenols inhibited Ca2+ - induced mitochondrial permeability transition, free radical generation in mitochondria during intoxication. The polyphenols (25 µg/ml) prevented mitochondrial oxidative impairments in vitro. In conclusion, the cranberry peel polyphenols with antioxidant properties exerted a hepatoprotective and anti-inflammatory effects in the model of alcoholic steatohepatitis via prevention of liver mitochondria dysfunction.Graphical abstractGraphical abstract for this article
       
  • Hepatoprotective effects of Moringa oleifera Lam (Moringaceae) leaf
           extracts in streptozotocin-induced diabetes in rats
    • Abstract: Publication date: June 2019Source: Journal of Functional Foods, Volume 57Author(s): Willy Tambwe Muzumbukilwa, Manimbulu Nlooto, Peter Mark Oroma OwiraEffects of methanolic leaf extracts of Moringa oleifera (MO) on hepatic injury in streptozotocin (STZ)-induced diabetes were investigated.Male Wister rats were divided into 6 groups (n = 7). Animals in group A were orally treated daily with 3.0 ml/kg/body weight (BW) of distilled water, while B, E and F were similarly treated with 500, 250 and 500 mg/kg/BW of MO, respectively. Groups C-F were rendered diabetic by single intraperitoneal injections of 45 mg/kg/BW of STZ. Additionally, group D was treated with subcutaneous insulin (2.0 U/kg/BW, bid).Diabetic animals exhibited significant weight loss, polydipsia, impaired glucose tolerance, fasting hypoinsulinemia and impaired liver function tests compared to controls. Treatment with MO methanolic leaf extracts significantly improved weight loss, polydipsia, glucose tolerance and also liver function tests in diabetic animals.MO has dose-dependent antidiabetic and hepatoprotective effects.Graphical abstractGraphical abstract for this article
       
  • MiRNA-320a is less expressed and miRNA-148a more expressed in preterm
           human milk compared to term human milk
    • Abstract: Publication date: June 2019Source: Journal of Functional Foods, Volume 57Author(s): Yaffa Elbaum Shiff, Shimon Reif, Ronella Marom, Kobi Shiff, Ram Reifen, Regina Golan-GerstlObjectivesTo investigate whether there is a difference in the profile of miRNAs between human milk (HM) from mothers of preterm versus HM from mothers of full-term infants. Second goal is to assess biological functions or implication related to those differences in miRNAs expression.MethodsFour of the highly expressed miRNAs in milk were detected by qRT-PCR. Milk derived exosomes were incubated with cells. The expression of miRNAs and target gene were detected by qRT-PCR.ResultsMiRNA-320 was more highly expressed in the colostrum of fullterm than in preterm HM. The expression of MiRNA-148 was higher in preterm mother's milk than of full-term colostrum. MiRNA-320 and MIRNA-148a expression were upregulated in cells incubated with milk exosomes, which lead to a decrease in their target genes FASN1 and DNMT1 respectivilly.ConclusionsAlterations in miRNAs expression in HM can affect biologic function in infants and may serve as a nutritional therapeutic target.Graphical abstractGraphical abstract for this article
       
  • Fucoidan from Acaudina molpadioides improves insulin resistance by
           altering gut microbiota dysfunction
    • Abstract: Publication date: June 2019Source: Journal of Functional Foods, Volume 57Author(s): Shiwei Hu, Jinhui Wang, Jingfeng Wang, Huicheng Yang, Xiaojun Yan, Laijinn SuThis study evaluated the effects of fucoidan from Acaudina molpadioides (Am-FUC) on modulation of the gut microbiota and improvement in insulin resistance in mice. Results showed that Am-FUC greatly alleviated insulin resistance and modified gut microbiota, involving Bacteroidetes and Firmicutes phylum. Am-FUC reducted serum and fecal lipopolysaccharide (LPS) concentrations and inhibited transcription of toll-like receptor 4 pathway. Meanwhile, fecal SCFAs were increases in Am-FUC-treated mice, which probably contributed to increases in G-protein-coupled receptor 43 protein and the activation of adenosine monophosphate activated protein kinase signaling. Strikingly, microbiota transplantation experiments exhibited that insulin resistance was significantly mitigated in high fat diet-fed recipient of Am-FUC microbiota. These suggest that Am-FUC improves insulin resistance by altering gut microbiota. Thus, it sought to indicate that fucoidan can be developed as food supplement for the improvement of insulin resistance and the human gut health.Graphical abstractGraphical abstract for this article
       
  • Polysaccharide peptides from Ganoderma lucidum ameliorate lipid metabolic
           disorders and gut microbiota dysbiosis in high-fat diet-fed rats
    • Abstract: Publication date: June 2019Source: Journal of Functional Foods, Volume 57Author(s): Xu-Cong Lv, Wei-Ling Guo, Lu Li, Xiao-Dan Yu, Bin LiuThis study aimed to investigate the effects of polysaccharide peptides from Ganoderma lucidum (GLPP) on hyperlipidaemia and gut microbiota dysbiosis in high-fat diet (HFD)-exacerbated hypercholesterolemic rats. Results showed that oral administrations of GLPP markedly alleviated the dyslipidaemia through decreasing the serum levels of triglyceride (TG), cholesterol (TC), free fatty acids (FFA) and low-density lipoprotein cholesterol (LDL-C), and significantly suppressing hepatic lipid accumulation and steatosis. Metagenomic analysis revealed that GLPP supplementation produced significant structure changes on the intestinal microbiota in HFD-fed rats, in particular modulating the relative abundance of functionally relevant microbial phylotypes compared with the HFD group. The Spearman's correlation analysis revealed that the serum and hepatic lipid profiles were negatively correlated with Jeotgalicoccus, Ignavigranum, Sporosarcina, Bacteroides, Anaerovorax, Parasutterella, Alistipes and Alloprevotella, but positively correlated with Allobaculum, Phascolarctobacterium, Psychrobacter, Enterorhabdus, Blautia and Roseburia. Meanwhile, the GLPP treatment regulated the mRNA expression responsible for hepatic lipid metabolism and promoted fecal excretion of total bile acids (BAs). These findings indicated that GLPP ameliorate lipid metabolic disorders through modulating gut microbiota structure and regulating the genes involved in hepatic lipid and cholesterol metabolism.Graphical abstractPolysaccharide peptides from Ganoderma lucidum (GLPP) have the potential to ameliorate lipid metabolic disorders, in part through modulating specific gut microbiota and regulating the mRNA expression levels of the genes involved in lipid and cholesterol metabolism, suggesting GLPP as a potential novel functional food for the treatment or prevention of hyperlipidaemia and gut microbiota dysbiosis.Graphical abstract for this article
       
  • Coeloglossum viride var. bracteatum extract improves learning and memory
           of chemically-induced aging mice through upregulating neurotrophins BDNF
           and FGF2 and sequestering neuroinflammation
    • Abstract: Publication date: June 2019Source: Journal of Functional Foods, Volume 57Author(s): Si-Jia Zhong, Lin Wang, Huan-Tong Wu, Rongfeng Lan, Xiao-Yan QinCE exerted neuroprotective effects against a range of oxidative stress and amyloid toxicity in neurons. Here, we investigated the anti-aging effects of CE in chemically-induced aging mice established by consecutive administration of D-galactose combined with AlCl3. Behavior analysis verified that CE significantly ameliorates learning and memory deficit of aging mice. CE treatment evoked the hippocampus expression of neurotrophins BDNF and FGF2, reactivated PI3K/Akt signaling pathway and rescued the decline of anti-apoptotic protein Bcl-2, but abolished the elevation of active Caspase-3. Meanwhile, the expression of inflammatory factors including TNF-α, IL-6, NOS2 and IL-1β was decreased. Collectively, we established the neuroprotective role of CE that ameliorates chemically-induced cognitive deficit through up regulation of BDNF and FGF2, reactivating the PI3K/Akt signaling pathway and sequestering neuroinflammation. Our work will assist in the development of functional food and medicine for clinical trials of anti-aging and dementia.Graphical abstractCoeloglossum viride var. bracteatum extract (CE), from a traditional Tibetan medicine Zang wangla, improves learning and memory of aging mice through upregulating neurotrophins BDNF and FGF2 and sequestering neuroinflammation.Graphical abstract for this article
       
  • Intake of fruit and leaves of sweet cherry beneficially affects lipid
           metabolism, oxidative stress and inflammation in Wistar rats fed with high
           fat-cholesterol diet
    • Abstract: Publication date: June 2019Source: Journal of Functional Foods, Volume 57Author(s): Kinga Dziadek, Aneta Kopeć, Ewa PiątkowskaThe aim of this study was to assess the effect of an addition of sweet cherry fruit or leaves (unexplored until now) to high fat-cholesterol (HFC) diet on selected biochemical parameters and expression of genes involved in fatty acid metabolism in male Wistar rats.The addition of sweet cherry fruit and leaves to HFC diet resulted in decrease in body gain, improvement of the liver function as well as reduction of oxidative stress and inflammation. Additionally, fruit and leaves had a beneficial impact on lipid metabolism, thereby reducing lipid accumulation in liver and improving lipid profile in the serum. These effects result from the regulation of expression of fatty acid synthesis and oxidation-related genes.It can be summarized that not only fruit of sweet cherry but also leaves, may have a potential application in the fight against non-communicable diseases, especially obesity and cardiovascular diseases.Graphical abstractGraphical abstract for this article
       
  • Bioactivities of wine components on marinated beef during aging
    • Abstract: Publication date: June 2019Source: Journal of Functional Foods, Volume 57Author(s): N.M.O. Arcanjo, D. Morcuende, M.J. Andrade, P. Padilla, M.S. Madruga, M. EstévezThe objective of this study was to identify particular wine components as responsible for the bioactivities observed in marinated bovine muscle Longissimus lumborum during 7 days of refrigerated storage at 4 °C. Depending on the grape variety, four marinades were considered (300 mL dealcoholized wine/kg meat): Carbernet (CAB), Tempranillo (TEM) and Isabel (ISA), including a control group of samples. CAB and TEM, rich in procyanidins, were more effective against lipid oxidation while ISA, rich in hydroxycinnamic acids, protected proteins against oxidation more efficiently. The lower Warner Bratzler shear force values in beef stakes marinated with ISA could be explained by the inhibition of protein cross-linking. Caftaric acid, the most abundant hydroxycinnamic acid in ISA, was tentatively identified as responsible for this relevant bioactivity. The particular phenolic composition of ISA wine and its high content in organic acids, may explain its effects against Enterobacteriaceae while sugars may have promoted the growth of lactic-acid bacteria in beef marinated with CAB and TEM.Graphical abstractGraphical abstract for this article
       
  • Chitooligosaccharide supplementation prevents the development of high fat
           diet-induced non-alcoholic fatty liver disease (NAFLD) in mice via the
           inhibition of cluster of differentiation 36 (CD36)
    • Abstract: Publication date: June 2019Source: Journal of Functional Foods, Volume 57Author(s): Mengyao Zhao, Xin Shen, Xiaodan Li, Baoli Chen, Liqiang Fan, Quanming Xia, Liming ZhaoThe effects of (GlcN)2-3 on the development of high fat diet-induced non-alcoholic fatty liver disease in C57BL/6J mice and the potential structural-functional relationship between different singular degrees of polymerization (DPs) COSs and CD36 activity were investigated. (GlcN)2-3 was found to significantly inhibit the levels of triglyceride, low density lipid protein and total cholesterol in the serum and liver, thus reducing hepatic steatosis and, ultimately, altering lipid accumulation. This phenomenon was associated with a decrease in the mRNA and protein expressions of CD36, PXR, DGAT2, LXRα and PPARγ, which subsequently decreased the uptake of FFAs and triglyceride synthesis. Using structural analysis, (GlcN)2-3 blocked the core cavity and inhibited the translocation of FFAs in CD36. Furthermore, the molecular size and steric hindrance effect play crucial roles in the deactivation of CD36. These findings will provide a better understanding of the modulating actions of specific singular-DPs COS in high fat diet-induced hepatic steatosis.Graphical abstractGraphical abstract for this article
       
  • Analgesic effect of Allium ampeloprasum: Evidence for the involvement of
           beta-adrenergic system
    • Abstract: Publication date: June 2019Source: Journal of Functional Foods, Volume 57Author(s): Manal A. AbbasAllium ampeloprasum (leek) is a bulbous perennial edible vegetable closely related to garlic (A. sativum L.). In this study, the antinociceptive, antidepressant and anxiolytic effects of A. ampeloprasum were studied. A. ampeloprasum inhibited abdominal cramps in writhing test and increased latency time in hot-plate and tail-flick tests. In formalin test, A. ampeloprasum inhibited paw licking in both early and late phases. Propranolol, but not naloxone or yohimbine, reversed this effect. A. ampeloprasum decreased the number of lines crossed in open field test but has no effect on the time spent in open arm in elevated plus maze or the immobility time in forced swimming test. GC–MS analysis resulted in the identification of 18 compounds with phytol acetate, linoleic acid and tricosane as major constituents. In conclusion, the analgesic action of A. ampeloprasum was mediated by interaction with β-adrenergic receptor. No antidepressant or anxiolytic effects were exerted by A. ampeloprasum.Graphical abstractGraphical abstract for this article
       
  • Egg yolk phosphatidylcholine: Extraction, purification and its potential
           neuroprotective effect on PC12 cells
    • Abstract: Publication date: May 2019Source: Journal of Functional Foods, Volume 56Author(s): Jin Chen, Songyi Lin, Na Sun, Zhijie Bao, Jiaying Shen, Xueqi LuPhosphatidylcholine (PC), a main phospholipid component in egg yolk, provides nourishment and protection for the body. In this study, an attempt has been made to explore the neuroprotective effect of PC that extracted and purified from egg yolk and its corresponding molecular species profile. Egg-yolk PC was obtained by solvent extraction and silica column chromatography, and the purity reached 98%. The neuroprotective effect of egg-yolk PC was investigated via scopolamine-induced PC12 cell model. The results indicated that the pre-treatment of egg-yolk PC could inhibit scopolamine-induced neurotoxicity and oxidative stress in PC12 cells via down-regulation of acetylcholinesterase (AChE) activity, monoamine oxidase (MAO) activity, and the malonaldehyde (MDA) level. This neuroprotective effect might be attributed to plentiful unsaturated fatty acids in egg-yolk PC that was identified to possess 9 kinds of molecular species including 16:0/16:0-PC, 16:0/16:1Δ9-PC, 16:0/18:0-PC, 16:0/18:1Δ9-PC, 16:0/18:2Δ9,12-PC, 18:0/18:1Δ9-PC, 18:0/18:2Δ9,12-PC, 18:1/18:2Δ9,12-PC and 18:0/20:4Δ5,8,11,14-PC by MALDI TOF-MS combined with GC-MS.Graphical abstractGraphical abstract for this article
       
  • Açaí (Euterpe oleracea Mart.) has anti-inflammatory potential through
           NLRP3-inflammasome modulation
    • Abstract: Publication date: May 2019Source: Journal of Functional Foods, Volume 56Author(s): Alencar Kolinski Machado, Francine Carla Cadoná, Charles Elias Assmann, Ana Cristina Andreazza, Marta Maria Medeiros Frescura Duarte, Cátia dos Santos Branco, Xinyang Zhou, Diulie Valente de Souza, Euler Esteves Ribeiro, Ivana Beatrice Mânica da CruzThere are several diseases, such as bipolar disorder, for example, where a chronic inflammation related to NLRP3 inflammasome is present. So, it is important to search for new anti-inflammatory agents. Açaí (Euterpe oleracea Mart.) is a Brazilian fruit with antioxidant and anti-inflammatory activities. However, the mechanism of açaí anti-inflammatory potential is still unclear. The objective of this study was to evaluate the anti-inflammatory effect of açaí extract and its mechanism. Macrophages were exposed to phytohemagglutinin to induce inflammation and treated with different concentrations of açaí extract. Cellular proliferation, cell cycle, oxidative metabolism parameters, inflammatory cytokines and NLRP3 have been assessed. 1 μg/mL of açaí extract was able to act as an antioxidant agent. Açaí extract decreased NLRP3 inflammasome levels and reduced pro-inflammatory cytokines. The extract caused cell cycle arresting and decreased proliferation. Obtained results suggest that açaí extract has anti-inflammatory effect and its mechanism of action involve NLRP3 inflammasome modulation.Graphical abstractGraphical abstract for this article
       
  • Characterization in vitro potency of biological active fractions of seeds,
           skins and flesh from selected Vitis vinifera L. cultivars and
           interspecific hybrids
    • Abstract: Publication date: May 2019Source: Journal of Functional Foods, Volume 56Author(s): Karolina Tkacz, Aneta Wojdyło, Paulina Nowicka, Igor Turkiewicz, Tomasz GolisThe aim of this study was to analyze phenolic compounds and in vitro biological activity of seeds, skins and flesh of V. vinifera cultivars and interspecific hybrids grown in Poland. Their phenolic profile was analyzed using LC-PDA-MS-QTOF and UPLC-PDA-FL and 48 compounds were identified, including nine phenolic acids, one stilbene, 12 anthocyanins, 10 flavonols and 16 flavan-3-ols. Seeds and red skins showed the highest antioxidant activity as measured with ABTS, FRAP and ORAC assays and on-line profiling by HPLC-PDA coupled with post-column derivatization with ABTS. Regarding anticholinergic activity, seeds and skins demonstrated higher AChE than BuChE activity, contrary to the flesh, where the ratio was reversed. In all seeds and most skins and flesh samples, inhibitory activity against α-glucosidase was higher than that against α-amylase. In conclusion, the investigated grape elements may be attractive components of functional foods and nutraceuticals, and seeds – being by-products of the wine industry – can be utilized.Graphical abstractGraphical abstract for this article
       
  • Fish oil protects against corn oil-induced cardiac insulin resistance and
           left ventricular dysfunction in rats via upregulation of PPAR-β/γ and
           inhibition of diacylglycerol/PCK axis activation
    • Abstract: Publication date: May 2019Source: Journal of Functional Foods, Volume 56Author(s): Refaat A. Eid, Mubarak Al-Shraim, Samy S. Eleawa, Mohamed Samir Ahmed Zaki, Attalla Farag El-kott, Muhammad Alaa Eldeen, Mahmoud A. Alkhateeb, Mohammed Alassiri, Hussain AlderahThis study investigated the effects corn oil (CO) and different ratios of corn oil plus fish oil (FO) on insulin signaling in rat's heart. Adult male rats were fed low (LFD) or isocaloric high-fat diets (HFDs) of CO alone or CO + FO (ratios of 9:1 or 4:1). Cultured cardiomyocytes were treated with linoleic acid (LA), DHA + EPA (1:1) or LA + (DHA + EPA) (1:1). CO induced peripheral and cardiac insulin resistance with mitochondria damage, lipotoxicity activation of PKCε. It also upregulated LV levels of PPARα and down regulated PPARβ/δ. FO antagonized corn oil effects at both ratio with more profound effects with the ratio of 4:1. The regulatory roles of CO and FO on PPARs was shown in cultured cardiomyocytes and independent of hyperinsulinemia or free fatty acids. In conclusion, reducing the ratio of n-6/n-3 PUFAs in our diet toward a value of one is cardioprotective.Graphical abstractProposed mechanisms for the effect of corn oil and fish oil on cardiac insulin sensitivity.Graphical abstract for this article
       
  • Identification of anti-diabetes peptides from Spirulina platensis
    • Abstract: Publication date: May 2019Source: Journal of Functional Foods, Volume 56Author(s): Shuangfei Hu, Xiaodan Fan, Ping Qi, Xuewu ZhangIn this study, ultrasound coupled with subcritical water (USW) technology was employed to extract S. platensis protein, and its inhibitory effect on three enzymes (α-amylase, α-glucosidase and dipeptidyl peptidase-4 (DPP-IV)) was evaluated. Subsequently, using insulin resistant-HepG2 cell model, the data presented that the USW-extracted protein significantly (p 
       
  • Eriocitrin in combination with resveratrol ameliorates LPS-induced
           inflammation in RAW264.7 cells and relieves TPA-induced mouse ear edema
    • Abstract: Publication date: May 2019Source: Journal of Functional Foods, Volume 56Author(s): Junlei Liu, Huarong Huang, Zebin Huang, Yuran Ma, Lanyue Zhang, Yan He, Dongli Li, Wenfeng Liu, Susan Goodin, Kun Zhang, Xi ZhengEriocitrin is a flavonoid that is isolated from orange peel. Resveratrol is a polyphenol compound, which is present in various fruits, such as grapes. The aim of the present study was to investigate both in vitro and in vivo anti-inflammatory effects of eriocitrin combined with resveratrol using lipopolysaccharide (LPS)-induced RAW264.7 cells and a mouse model of ear edema. The results showed that eriocitrin combined with resveratrol strongly inhibited LPS-induced secretion of nitric oxide (NO), tumor necrosis factor-α (TNF-α), and Interleukin-1β (IL-1β). Moreover, Eriocitrin combined with resveratrol potently inhibited nuclear factor-κB (NF-κB), phosphor-STAT3, and phosphor-AKT, which was accompanied by inhibition of phosphorylation in mitogen-activated protein kinase (MAPK) signaling pathways. Treatment with eriocitrin combined with resveratrol alleviated edema and subcutaneous tissue inflammation caused by 12-O-tetradecanoylphorbol-13-acetate (TPA) in vivo. This study also demonstrated that treatment with eriocitrin and resveratrol decreased the levels of the pro-inflammatory cytokines TNF-α and IL-1β. The results of the present study indicate that eriocitrin combined with resveratrol effectively inhibits inflammatory responses both in vitro and in vivo.Graphical abstractGraphical abstract for this article
       
  • Taurine reduces hyperactive behavior in SHR rats through upregulating the
           proportion of CD4+CD25+Foxp3+ regulatory T cells
    • Abstract: Publication date: May 2019Source: Journal of Functional Foods, Volume 56Author(s): Vincent Chin-Hung Chen, Chun-Ching Chiu, Jun-Cheng Weng, Li-Jeng Chen, Jing Yi Siow, Tsai-Ching Hsu, Bor-Show TzangAttention deficit hyperactivity disorder (ADHD) is a most common mental illness in both children and adults. Our recent studies revealed that high-dose taurine improves hyperactivity in SHR rats by reducing mALFF signal and striatal dopamine uptake. This study further revealed the association between immune factors and hyperactivity in SHR rats fed with high-dose taurine. A positive correlation was detected between systolic blood pressure (SBP) and horizontal locomotion in SHR rats fed with high-dose taurine. Significantly higher striatal Hsp27 and galectin-3 were detected in SHR rats fed with high-dose taurine. Significantly lower IL-2 and IL-6 were detected in SHR rats fed with high-dose taurine, whereas significantly higher IL-10 was detected. Significantly increased splenic CD4+CD25+Foxp3+ regulatory T cells was detected in SHR rats fed with high-dose taurine with a negative correlation. These findings suggest that high-dose taurine reduce hyperactive behavior in SHR rats probably via multifactorial modulation on immune system.Graphical abstractGraphical abstract for this article
       
  • Trehalose attenuates development of nonalcoholic steatohepatitis
           associated with type 2 diabetes in TSOD mouse
    • Abstract: Publication date: May 2019Source: Journal of Functional Foods, Volume 56Author(s): Kazutoshi Murotomi, Shigeyuki Arai, Aki Suyama, Akira Harashima, Yoshihiro NakajimaTrehalose, a non-reducing disaccharide, induces autophagy. Trehalose mitigates insulin resistance and adipocyte hypertrophy in obese mice; however, its effect on the development of nonalcoholic steatohepatitis (NASH) associated with type 2 diabetes remains unknown. In this study, we investigated the effect of trehalose on the development of NASH in the Tsumura Suzuki Obese Diabetes (TSOD) mouse, a metabolic syndrome model characterized by obesity, type 2 diabetes, and NASH. We found that trehalose intake markedly inhibited histopathological features of NASH, particularly hepatic steatosis and liver cell injury, in TSOD mice. Trehalose intake attenuated increase in mesenteric adipose tissue weight, impaired glucose tolerance, and iron deposition in the duodenum, suggesting that trehalose prevents insulin resistance and iron absorption in TSOD mice. These findings indicate that trehalose attenuates the development of NASH associated with type 2 diabetes, and this attenuation may be mediated by prevention of lipid accumulation and iron absorption.Graphical abstractGraphical abstract for this article
       
  • Probiotics administration or the high-fat diet arrest modulates microRNAs
           levels in hyperlipidemic hamsters
    • Abstract: Publication date: May 2019Source: Journal of Functional Foods, Volume 56Author(s): Loredan S. Niculescu, Madalina D. Dulceanu, Camelia S. Stancu, Mihaela G. Carnuta, Teodora Barbalata, Anca V. SimaTo evaluate the modulation of RNA-related epigenetic factors by dietary interventions in hyperlipidemia (HL), male Golden-Syrian hamsters fed 16-weeks a high-fat diet (HFD, standard chow plus 3% cholesterol/15% butter) were subjected for another 5 weeks to: (1) probiotics administration (Bifidobacterium/Lactobacillus) together with HFD or (2) HFD withdrawal. Lipids and lipid-related miRNAs (miR-223, miR-122, miR-486, miR-92a) levels in liver and serum and hepatic lipid-related genes expression were assessed in all hamsters. Results indicated that probiotics or HFD arrest lowered lipids and miRNAs levels in HL hamsters. Probiotics modulated the miRNAs processing proteins (Dicer, DGCR8), without restoration of cholesterol metabolism mediators expression (LDLR, HMGCS1, HMGCR, SR-BI). In contrast, HFD arrest did not alter the miRNAs processing proteins, while cholesterol metabolism-related genes expressions were restored to normal. In conclusion, the hypolipidemic dietary interventions decrease lipid-related miRNAs levels in serum and liver, but affect differently the genetic and RNA-related epigenetic factors in HL liver.Graphical abstractGraphical abstract for this article
       
  • Inhibitory mechanism of novel allosteric inhibitor, Chinese bayberry
           (Myrica rubra Sieb. et Zucc.) leaves proanthocyanidins against
           α-glucosidase
    • Abstract: Publication date: May 2019Source: Journal of Functional Foods, Volume 56Author(s): Mengting Wang, Jing Jiang, Jinhu Tian, Shiguo Chen, Xingqian Ye, Yaqin Hu, Jianchu Chenα-Glucosidase is a key enzyme related to starch digestion and type-2 diabetes. In the present study, the inhibition effect and the underlying mechanism of Chinese bayberry leaves proanthocyanidins (BLPs) on α-glucosidase were investigated by enzyme kinetic analysis, multi-spectroscopy and molecular docking simulation. The results revealed that BLPs was a high potential noncompetitive-type inhibitor of α-glucosidase with the half maximal inhibitory concertation (IC50) value of 0.037 ± 0.001 mg mL−1 and acarbose equivalent (AE) of 517.01 mmol AE g−1. What’s more, BLPs may interact with some amino acids surrounded in the allosteric site of α-glucosidase to form a complex driven by hydrogen bonding and hydrophobic interaction, and thus change the structure and microenvironment of α-glucosidase, leading to the decrease of activity of α-glucosidase. The present study suggested that BLPs as epigallocatechin-3-O-gallate (EGCG) polymers could be a novel α-glucosidase inhibitor and had potential to be further used in functional food or anti-diabetic drug.Graphical abstractGraphical abstract for this article
       
  • Antioxidant dietary fibre from grape pomace flour or extract: Does it make
           any difference on the nutritional and functional value'
    • Abstract: Publication date: May 2019Source: Journal of Functional Foods, Volume 56Author(s): Carolina Beres, Suely Pereira Freitas, Ronoel Luiz de Oliveira Godoy, Denize Cristine Rodrigues de Oliveira, Rosires Deliza, Marcello Iacomini, Caroline Mellinger-Silva, Lourdes Maria Correa CabralWhite wine Pinot noir grape pomace was dried and milled into flour or extracted in hot water and dried. Both ingredients were analysed and compared according to nutritional and biological value. The extract presented higher mineral and soluble fibre content. After a human digestion simulation, phenolic content and antioxidant capacities were also higher in the extract. After a 5 kDa filtration of the digested fractions, the gastric and enteric retentates from the extract showed higher bioactive value, and gallic, vanillic and seringic acids were the main bioaccessible phenolic compounds. As the extract was a more nutritious and functional ingredient compared to the flour, it was incorporated into a yogurt formulation and tested in a sensorial panel. The overall liking score was 6.2 out of 9.0 and 51% of panellists indicated that certainly would buy the product. The results indicated a promising application for the extract as an antioxidant dietary fibre ingredient.Graphical abstractGraphical abstract for this article
       
  • Structural characterization of a novel polysaccharide from Hericium
           erinaceus and its protective effects against H2O2-induced injury in human
           gastric epithelium cells
    • Abstract: Publication date: May 2019Source: Journal of Functional Foods, Volume 56Author(s): Bingwu Liao, Huihua HuangIn this paper, a novel water-soluble polysaccharide (HEPW1) was extracted from Hericium erinaceus, physicochemical characterization showed that HEPW1 with a relative molecular weight of 5.163 kDa was composed of fucose (6.13%), glucose (72.28%) and galactose (21.59%). A H2O2-induced cellular injury model for human gastric epithelium (GES-1) cells was established and used to investigate the protective effects of HEPW1 against this oxidative stress. It was found that HEPW1 could significantly protect GES-1 cells from H2O2-induced oxidative stress by enhancing the antioxidant capacity of intracellular substances of the treated cells and regulating intracellular antioxidant enzyme system, inhibiting H2O2-induced apoptosis, blocking cell cycle, reducing ROS, attenuating DNA damage and preserving cell membranes. This research is useful for the prevention or treatment of oxidation-related diseases and is also beneficial for the development of healthy foods containing fungal polysaccharides.Graphical abstractGraphical abstract for this article
       
  • Effects of Flammulina velutipes polysaccharide on immune response and
           intestinal microbiota in mice
    • Abstract: Publication date: May 2019Source: Journal of Functional Foods, Volume 56Author(s): Ruiqiu Zhao, Qiuhui Hu, Gaoxing Ma, Anxiang Su, Minhao Xie, Xiangfei Li, Guitang Chen, Liyan ZhaoA crude polysaccharide derived from Flammulina velutipes (FVP), mainly consisting of glucose linked with β-glycosidic bonds, was administered to 6 week-old male ICR mice by gavage for five weeks, to investigate the effects on mice intestinal microbiota and immune response. The pH of the intestinal compartments decreased while short chain fatty acids concentrations increased in FVP-fed groups, in a dose dependent manner. High throughput sequencing revealed the enrichment in the diversity and an alteration in the composition of the fecal microbiota in the FVP fed mice. A significant decrease in the Firmicutes/Bacteroidetes ratio, relative abundances of Lactobacillus and Akkermansia were related to the energy absorption. The relative abundances of Porphyromonadaceae and Bacteroidaceae positively correlated with an increase in serum immunoglobulin and cytokines. This study indicated that this crude polysaccharide from F. velutipes could modulate the gut microbiota and represented a potential capacity of obesity suppression and immune regulation.Graphical abstractGraphical abstract for this article
       
  • Bound polyphenol from foxtail millet bran exhibits an antiproliferative
           activity in HT-29 cells by reprogramming miR-149-mediated aerobic
           glycolysis
    • Abstract: Publication date: May 2019Source: Journal of Functional Foods, Volume 56Author(s): Jiangying Shi, Shuhua Shan, Guofang Zhou, Hanqing Li, Guisheng Song, Zhuoyu Li, Dongfeng YangColorectal cancer (CRC) is an intractable intestinal tumor. Cancer cells prefer to aerobic glycolysis to meet the requirements of rapid proliferation. Hence, discovery of a bioactive molecule cold inhibit aerobic glycolysis, which is regarded as a effective strategies for prevention and treatment of CRC. In this study, we first discovered a foxtail millet bran-derived bound polyphenol (BPIS) with anti-proliferative activity in HT-29 cell (colon cancer cell lines) and its nude mice model. The data further indicated the anti-CRC active ingredients and molecular mechanisms of BPIS. Here we revealed that BPIS could act anti-proliferative activity in HT-29 cells depending on reversing aerobic glycolysis, and this effect was achieved by up-regulation of miR-149 expression by BPIS, which directly targeted the 3′-UTR of c-myc, thereby inhibiting PKM2-mediated aerobic glycolysis. Therefore, BPIS might be used as a new inhibitor of glycolysis for enhancing intestines health benefits.Graphical abstractA suggested model for the regulation of aerobic glycolysis in colorectal cancer cells by BPIS. BPIS up-regulated miR-149 level, which lead to the expression inhibition of c-myc. Furthermore, BPIS inhibited c-myc-mediated glycolysis by regulating PKM2 expression and lactate production in colorectal cancer cells. The function of BPIS notably inhibited aerobic glycolysis, which resulted in the decrease of internal ATP levels and an increase in cell death.Graphical abstract for this article
       
  • A probiotic formulation containing Lactobacillus bulgaricus DWT1 inhibits
           tumor growth by activating pro-inflammatory responses in macrophages
    • Abstract: Publication date: May 2019Source: Journal of Functional Foods, Volume 56Author(s): Dipanjan Guha, Arka Banerjee, Raktim Mukherjee, Biswaranjan Pradhan, Maria Peneva, Georgi Aleksandrov, Sujit Suklabaidya, Shantibhushan Senapati, Palok AichProbiotics are functional foods and are becoming more evident with time that probiotics can have prophylactic and therapeutic roles. Current report revealed that an established probiotic cocktail of Lactobacillus delbruckei sp. bulgaricus DWT1 and Streptococcus thermophilus DWT4, could inhibit tumor growth. This probiotic cocktail is already marketed in various forms of food supplement. Present report reveals the transition of M2 to M1 like state of macrophage cells of mouse origin in vitro, ex vivo and in vivo following treatment with the established probiotic cocktail. Current study for the first time suggests the ability of a probiotic formulation to polarize macrophages from M2 to M1 state with potentials of developing newer intervention strategies for tumor growth. As a validation of our claim, we have established a novel and significant way of tumor inhibition in mouse model by the probiotic formulation that is capable of polarizing macrophages from M2 to M1.Graphical abstractGraphical abstract for this article
       
  • Raspberry extract prevents NLRP3 inflammasome activation in gut epithelial
           cells induced by pathogenic Escherichia coli
    • Abstract: Publication date: May 2019Source: Journal of Functional Foods, Volume 56Author(s): Yansong Xue, Min Du, Mei-Jun ZhuRaspberry extract is known for its anti-inflammatory effects, but its effectiveness against pathogenic Escherichia coli-induced inflammasome activation in epithelial cells is largely unknown. This study showed that raspberry extract treatment prevented oxidative stress in Caco-2 cells infected by E. coli O157:H7 and had prophylactic effects against E. coli O157:H7-induced NLRP3 inflammasome activation. In addition, raspberry extract mitigated reduction of nuclear translocation of nuclear factor erythroid 2-related factor 2 (NRF2), a key transcription factor regulating antioxidant protein expression and nitric oxide production in Caco-2 cells upon E. coli O157:H7 infection. However, raspberry extract failed to restore NRF2 nuclear content or nitric oxide production in Caco-2 cells in the presence of aminoguanidine hydrochloride, an iNOS inhibitor. Collectively, raspberry extract treatment suppressed NLRP3 mediated inflammatory response and oxidative stress in Caco-2 cells induced by E. coli O157:H7 infection. These protective effects were partially mediated by enhanced NRF2 signaling pathway and nitric oxide production.Graphical abstractGraphical abstract for this article
       
  • Functional food development: Insights from TRP channels
    • Abstract: Publication date: May 2019Source: Journal of Functional Foods, Volume 56Author(s): Zhi-Ming Zhang, Xiao-li Wu, Guang-yuan Zhang, Xin Ma, Dong-Xu HeAbstractThe transient receptor potential (TRP) channels comprise a large family of ion channels that control a vast array of cellular functions. Growing evidence has demonstrated that a diversity of bioactive components from foods activate or inhibit different types of TRP channels, and interfere with related pathophysiological processes. This review highlights current advances in finding various bioactive components from foods that target TRP channels, and ends with comments on the potential of functional foods that target TRP channels. Furthermore, some types of TRP-related functional food products currently on the market are discussed.
       
  • Gene-based analysis of angiogenesis, mitochondrial and insulin-related
           pathways in skeletal muscle of older individuals following nutraceutical
           supplementation
    • Abstract: Publication date: May 2019Source: Journal of Functional Foods, Volume 56Author(s): Hannah Crossland, Suzette L. Pereira, Kenneth Smith, Bethan E. Phillips, Philip J. AthertonCocoa flavanols and fish oil omega-3 fatty acids are two bio-active nutrients that may improve muscle microvascular function, insulin sensitivity and mitochondrial function in older adults. We assessed changes in gene expression of these pathways in muscle from two nutritional intervention studies in older healthy volunteers: (i) 6-weeks daily fish oil supplementation in older females (3.4 g/d; age: 64.4 ± 0.8 y, BMI: 26.2 ± 0.7 kg/m2), and (ii) 7-day daily cocoa flavanol supplementation in older males (1050 mg/d; age: 70.1 ± 0.9 y, BMI: 25.7 ± 0.6 kg/m2). There was a main effect of 6-weeks fish oil supplementation on angiogenesis gene expression, with no overall changes in mitochondrial or insulin signaling genes. 7-day cocoa supplementation elicited changes in extracellular matrix (ECM) related genes. Thus, the effects of fish oil supplementation on vascular remodeling in skeletal muscle, and ECM remodeling with cocoa supplementation have emerged as areas for future study.Graphical abstractGraphical abstract for this article
       
  • The edible native Australian fruit, Davidson’s plum (Davidsonia
           pruriens), reduces symptoms in rats with diet-induced metabolic syndrome
    • Abstract: Publication date: May 2019Source: Journal of Functional Foods, Volume 56Author(s): Oliver D. John, Peter Mouatt, Indira Prasadam, Yin Xiao, Sunil K. Panchal, Lindsay BrownDavidson’s plum is a native Australian fruit used traditionally as food and medicine. The fruit contains anthocyanins as glucosides and sambubiosides of cyanidin and peonidin (691 mg/100 g of dried pulp) with rutin and quercetin glycosides (193 mg/100 g). Dietary supplementation of Davidson’s plum at approximately 8 mg anthocyanins/kg/day in rats attenuated the signs of metabolic syndrome induced by high-carbohydrate, high-fat diet. Davidson’s plum reduced visceral fat accumulation, total abdominal fat weight, size of retroperitoneal adipocytes, and plasma triglycerides and non-esterified fatty acids, normalised blood pressure, reduced left ventricular stiffness, decreased infiltration of inflammatory cells in both left ventricle and liver, decreased collagen deposition in heart, and reduced both fat vacuoles in liver and obesity-induced degeneration of knee cartilage. There were no changes in glucose tolerance with treatment. Davidson’s plum reduced colonic Clostridiaceae spp, and increased Turicibacter spp. and Akkermansia muciniphila. Our findings indicate that Davidson’s plum is a potential complementary treatment for metabolic syndrome.Graphical abstractGraphical abstract for this article
       
  • Cyanidin 3-glucoside from Queen Garnet plums and purple carrots attenuates
           DSS-induced inflammatory bowel disease in rats
    • Abstract: Publication date: May 2019Source: Journal of Functional Foods, Volume 56Author(s): Naga K.R. Ghattamaneni, Sunil K. Panchal, Lindsay BrownWe have investigated whether dextran sodium sulphate (DSS)-induced inflammatory bowel disease (IBD) in rats can be ameliorated by intervention with cyanidin 3-glucoside (C3G). Rats were given either normal water (C) or 0.5% DSS (D) in drinking water for 12 weeks. C3G 8 mg/kg/day as Queen Garnet plum (Q) juice, purple carrot (P) juice or pure compound was added in food for final 6 weeks to C rats to give CQ, CP and CC groups, and to D rats to give DQ, DP and DC groups. No symptoms of IBD were observed in C, CQ, CP or CC rats. D rats had bloody diarrhoea, ileal and colonic mucosal atrophy, and inflammation. Compared to D rats, DQ, DP and DC rats showed improved stool consistency (P 
       
  • Glycated whey proteins protect NOD mice against type 1 diabetes by
           increasing anti-inflammatory responses and decreasing autoreactivity to
           self-antigens
    • Abstract: Publication date: May 2019Source: Journal of Functional Foods, Volume 56Author(s): Yingjia Chen, Tamas Nagy, Tai L. GuoOur previous studies suggested that early glycation products (EGPs) generated in the first step of Maillard reaction/glycation were anti-inflammatory. The objectives of the present study were to determine the effects of EGPs derived from the whey protein isolate-glucose system on type 1 diabetes (T1D), and the underlying immunological mechanisms. In non-obese diabetic (NOD) mice, EGPs at the physiological dose of 600 mg/kg/day increased glucose metabolism, decreased non-fasting blood glucose levels and T1D incidence, decreased insulin resistance, and decreased the pancreatic immune infiltration. The protective effects were accompanied with decreases in CD4−CD8+ thymocytes, CD8+ T cells and serum insulin autoantibody levels, and increases in splenic CD4+CD25+ T cells, macrophage M2/M1 ratio and serum IL-10 level. However, similar treatment with EGPs produced minimal effect on the multiple low-dose streptozotocin-induced hyperglycemia. In conclusion, EGPs protected NOD mice against T1D via increasing anti-inflammatory immune responses and decreasing autoreactivity to self-antigens.Graphical abstractGraphical abstract for this article
       
  • The mixture of corn and wheat peptide prevent diabetes in NOD mice
    • Abstract: Publication date: May 2019Source: Journal of Functional Foods, Volume 56Author(s): Suling Sun, Guowei Zhang, Hongyan Mu, Hao Zhang, Yong Q. ChenCorn peptide promotes glucagon-like peptide-1 release in type 2 diabetic animals, while wheat peptide increases pro-inflammatory cytokine response in type 1 diabetic patients. However, the effect of a mixture of corn and wheat peptide on the initiation and the development of type 1 diabtes remains unclear. Corn peptide reduced the blood glucose in wheat peptide-evoked diabetic NOD mice. A mixture of corn and wheat peptide significantly delayed the initiation and decreased the incidence of diabetes in NOD mice. In addition to the improved oral glucose tolerance, level of interleukin (IL)-6 and the insulitis score were decreased, while β-cell areas and IL-10 gene expression were increased via treatment with this peptide mixture. Meanwhile, serine and histidine levels in the serum were significantly increased in this peptide mixture treated NOD mice. Our data suggested that a mixture of corn and wheat peptide could prevent diabetes in NOD mice.Graphical abstractsA mixture of corn and wheat peptide delayed the initiation and decreased the incidence of diabetes in NOD mice.Graphical abstract for this article
       
  • Hypolipidemic effects of dietary fibre from an artichoke by-product in
           Syrian hamsters
    • Abstract: Publication date: May 2019Source: Journal of Functional Foods, Volume 56Author(s): María José Villanueva-Suárez, Inmaculada Mateos-Aparicio, María Luisa Pérez-Cózar, Wallace Yokoyama, Araceli Redondo-CuencaDietary fibre, including inulin-type fructans, from artichoke by-product were analyzed to understand the potential hypolipidemic effects over Syrian Hamsters fed a high fat diet. A decrease (p 
       
  • A new insight on elderberry anthocyanins bioactivity: Modulation of
           mitochondrial redox chain functionality and cell redox state
    • Abstract: Publication date: May 2019Source: Journal of Functional Foods, Volume 56Author(s): Dina Neves, Patrícia Valentão, João Bernardo, Maria C. Oliveira, Jorge M.G. Ferreira, David M. Pereira, Paula B. Andrade, Romeu A. VideiraAn elderberry anthocyanin-enriched extract was prepared and characterized in terms of phenolic composition and bioactivity, in order to evaluate its potential to target oxidative stress and mitochondrial dysfunction, which are early pathological events detected in neurodegenerative diseases. Beyond the remarkable antioxidant activity, anthocyanin-enriched extract exhibits affinity for mitochondrial membranes and reversible redox behaviour within the range of mitochondrial redox chain potentials. It does not affect the respiratory parameters of brain mitochondria, but it is able to overcome the mitochondrial complex I impairment promoted by rotenone. Anthocyanin-enriched extract protects SH-SY5Y cells from rotenone-induced cytotoxicity, modulated cell redox state and increased intracellular levels of reactive oxygen species. Exposure of elderberry extract to SH-SY5Y cells increases the activity of antioxidant enzymes and mitochondrial respiratory complexes. Therefore, the anthocyanin-enriched extract is a promising alternative agent to modulate mitochondrial dysfunctions and redox state of cells, with high relevance of neurodegenerative diseases such as Parkinson’s disease.Graphical abstractGraphical abstract for this article
       
  • Silymarin protects against high fat diet-evoked metabolic injury by
           induction of glucagon-like peptide 1 and sirtuin 1
    • Abstract: Publication date: May 2019Source: Journal of Functional Foods, Volume 56Author(s): Kai-Jyun Chang, Jer-An Lin, Sheng-Yi Chen, Ming-Hung Weng, Gow-Chin YenHigh-fat diet (HFD) is one of the major causes of increased prevalence of the metabolic syndrome. In this study, effect of silymarin on prevention and improvement of metabolic injury in HFD-induced rats was assessed. Results showed that silymarin intervention from 0 week or 8th week of the time course in the experiment significantly improved metabolic syndromes, including insulin resistance and dyslipidemia in high fat diet-treated rats. Silymarin also can ameliorate the HFD-impaired glucose tolerance and recover, further enhance HFD-impaired glucagon-like peptide 1 (GLP-1) secretion in these rats. Intervention of silymarin from 0 week can prevent HFD-induced hepatic steatosis, pancreas fibrosis, and decreased sirtuin 1 protein levels of pancreas and liver in rats. In conclusion, silymarin can prevent and ameliorate HFD-induced metabolic syndrome, as well as improvement of GLP-1 secretion and Sirt1 protein expression, suggesting that silymarin may be a potential food factor against metabolic injury.Graphical abstractGraphical abstract for this article
       
  • Young apple polyphenols postpone starch digestion in vitro and
           in vivo
    • Abstract: Publication date: May 2019Source: Journal of Functional Foods, Volume 56Author(s): Dan Li, Lijun Sun, Yongli Yang, Zichao Wang, Xi Yang, Ting Zhao, Tian Gong, Li Zou, Yurong GuoType II diabetes is largely related with hyperglycemia that can be controlled through inhibition the activities of carbohydrate-hydrolyzing enzymes by dietary polyphenols. This study aims to explore the effects of young apple polyphenols (YAP) on starch digestion in vitro and in vivo by acute and 1-week intervention administrations using mice. It was found that YAP was able to inhibit the starch digestive enzymes including α-amylase and α-glucosidase, in which tannic acid and chlorogenic acid showed inhibition on α-amylase, and tannic acid and phlorizin showed inhibition on α-glucosidase. In addition, the levels of postprandial blood glucose and insulin were lowered by around 10% at a peak for the mice fed with combination of starch and YAP than that only fed with starch, which was observed for acute and 1-week administrations. Taken together, YAP may have potentials as a functional food in assisting prevention and alleviation of type II diabetes disease.Graphical abstractGraphical abstract for this article
       
  • Queen Garnet plum juice and raspberry cordial in mildly hypertensive obese
           or overweight subjects: A randomized, double-blind study
    • Abstract: Publication date: May 2019Source: Journal of Functional Foods, Volume 56Author(s): Maharshi Bhaswant, Lindsay Brown, Michael L. MathaiThe anthocyanin, cyanidin 3-glucoside, in Queen Garnet (QG) plums reduced cardiovascular parameters, obesity and inflammation in diet-induced metabolic syndrome in rats. We have now assessed whether QG juice improves cardiovascular and metabolic risk factors and markers of inflammation in mildly hypertensive overweight or obese humans. The 32 subjects were randomly divided into two groups consuming either QG juice or Placebo (raspberry cordial) drinks for 12 weeks. QG juice decreased systolic blood pressure by 12 ± 3 mmHg, diastolic blood pressure by 9 ± 2 mmHg, insulin by 6 ± 3 pmol/L, and leptin by 4 ± 2.5 ng/ml, and increased adiponectin by 3.62 ± 0.28 µg/ml. Cyanidin 3-glucoside is the likely active component of the plum juice, with possible additive effects of other flavonoids such as quercetin glycosides. Thus, QG juice decreased blood pressure and attenuated some risk factors of metabolic syndrome after 12 weeks suggesting that daily consumption could attenuate the development of cardiovascular and metabolic diseases.Graphical abstractGraphical abstract for this article
       
  • cAMP-PKA dependent ERK1/2 activation is necessary for vanillic acid
           potentiated glucose-stimulated insulin secretion in pancreatic β-cells
    • Abstract: Publication date: May 2019Source: Journal of Functional Foods, Volume 56Author(s): V.P. Mahendra, Devendra J. Haware, Ravi KumarVanillic acid (VA), a dietary phenolic compound is generally studied for its anti-oxidative and anti-inflammatory effects. However, the effect of VA on insulin secretion and its mechanism of action has never been explored. In this study, we report that VA augments glucose-stimulated insulin secretion (GSIS) in both insulin-secreting cell-line INS-1 and isolated rat pancreatic islets. Potentiation of GSIS is accompanied by a concurrent increase in 3′,5′-cyclic adenosine monophosphate (cAMP) and activation of protein kinase A (PKA) in INS-1 and rat islets. The activated cAMP-PKA pathway, in turn, phosphorylates extracellular signal-regulated kinases 1/2 (ERK1/2) in INS-1 cells. Pharmacological intervention with PKA and ERK1/2 inhibitors revealed that VA potentiated GSIS is primarily dependent on PKA mediated ERK1/2 activity. These findings demonstrated that VA directly acts on insulin-secreting pancreatic β-cells to exert its insulinotropic effect thereby providing a novel role of VA in the regulation of insulin secretion.Graphical abstractGraphical abstract for this article
       
  • Anti-pancreatic cancer activity of Z-ajoene from garlic: An inhibitor of
           the Hedgehog/Gli/FoxM1 axis
    • Abstract: Publication date: May 2019Source: Journal of Functional Foods, Volume 56Author(s): Hwa Jin Lee, Ji Hye Jeong, Jae-Ha RyuOverexpression of glioma-associated oncogene (Gli), a transcription factor at the final step of Hedgehog (Hh) pathway, is involved in pancreatic cancer development. Therefore, inhibition of Gli can be a therapeutic strategy to treat pancreatic cancer. The objective of this study was to determine effects of Z-ajoene from garlic, on Gli-mediated transcription and proliferation of pancreatic cancer cells. We found that Z-ajoene could inhibit Gli transcriptional activity in Sonic Hedgehog (Shh) stimulated C3H10T1/2 mesenchymal stem cells. Z-Ajoene suppressed Gli transcriptional activity and Gli-target protein expressions in PANC-1 human pancreatic cancer cells. Z-Ajoene also reduced expression of FoxM1, one of Gli-target proteins, and subsequently down-regulated expressions of cell cycle-related proteins. Moreover, Z-ajoene reduced cell proliferation and increased G2/M phase of PANC-1 cells. These results suggest that Z-ajoene can repress pancreatic cancer cell proliferation by inhibiting Gli signaling. Thus, Z-ajoene might be a lead compound for the development of anti-pancreatic cancer agent.Graphical abstractGraphical abstract for this article
       
  • The effects of supplementation with blueberry, cyanidin-3-O-β-glucoside,
           yoghurt and its peptides on obesity and related comorbidities in a
           diet-induced obese mouse model
    • Abstract: Publication date: May 2019Source: Journal of Functional Foods, Volume 56Author(s): Min Shi, Michael L. Mathai, Guoqin Xu, Andrew J. McAinch, Xiao Q. SuIt is widely acknowledged that type 2 diabetes mellitus (T2DM) is associated with obesity, insulin resistance and hypertension. Cyanidin-3-O-β-glucoside (C3G), an anthocyanin in blueberry, and peptides with angiotensin converting enzyme (ACE) inhibitory activity derived from yoghurt are potentially beneficial for numerous health conditions including improving insulin resistance and glucose intolerance. In this study, the synergistic/additive effects of combined supplementations with blueberry and yoghurt, and C3G and peptides were determined. Blueberry and yoghurt alone, and the combination of C3G and peptides significantly reduced both systolic and diastolic blood pressure in diet-induced obese mice. Yoghurt supplementation significantly reduced body weight, percentage body fat and improved intraperitoneal glucose tolerance. Furthermore, peptides and the combination of peptides and C3G resulted in a significant reduction of percentage body fat and improved intraperitoneal glucose tolerance. As widely available, safe and nutritious foods, blueberry and yoghurt showed therapeutic potential in the treatment of obesity, diabetes and hypertension.Graphical abstractThe effects of blueberry and fermented yoghurt and their bioactive components [Cyanidin-3-O-β-glucoside (C3G) and peptides with angiotensin converting enzyme inhibitory activity] on obesity and its related comorbidities in high-fat-high-carbohydrate-diet (HFHC) induced obese mice. All results in supplementation groups were compared with the HFHC control group.Graphical abstract for this article
       
  • A lactate-based compound containing caffeine in addition to voluntary
           running exercise decreases subcutaneous fat mass and improves glucose
           metabolism in obese rats
    • Abstract: Publication date: May 2019Source: Journal of Functional Foods, Volume 56Author(s): Takeshi Hashimoto, Takumi Yokokawa, Ryoko Narusawa, Yoko Okada, Rika Kawaguchi, Kazuhiko HigashidaWe examined the effect of a lactate-based compound containing caffeine with voluntary running exercise on fat loss and metabolic improvement in diet-induced obese (DIO) rats. The rats treated with exercise training (Ex) and the compound (i.e., 1000 mg/kg body weight of sodium lactate and 36 mg/kg body weight of caffeine) with exercise training (ExLC) for 5 weeks showed decreased epididymal and scapular fat mass compared to the sedentary (S) rats, while LC rats displayed significantly decreased scapular fat mass compared to the Ex rats. The area under the curve for the LC rats during an oral glucose tolerance test was significantly lower compared with the S and Ex rats. Thus, administration of a lactate-based compound containing caffeine can effectively decrease fat mass and improve glucose tolerance even with low volume exercise training in DIO rats.Graphical abstractGraphical abstract for this article
       
  • Mangifera indica leaves extract and mangiferin modulate CB1 and PPARγ
           receptors and others markers associated with obesity
    • Abstract: Publication date: May 2019Source: Journal of Functional Foods, Volume 56Author(s): Larissa Froede Brito, Douglas Costa Gontijo, Renata Celi Lopes Toledo, Rafael Mazioli Barcelos, Alaíde Braga de Oliveira, Geraldo Célio Brandão, Lirlândia Pires de Sousa, Sônia Machado Rocha Ribeiro, João Paulo Viana Leite, Luciano Gomes Fietto, José Humberto de QueirozThis study aimed phytochemical characterization (UPLC-DAD-MS/MS) of ethanolic extract of the leaves from Mangifera indica (EMI) and Mangiferin (MAN), analysis of the cytotoxic (MTT) and anti-inflammatory potential (expression of TNF-α) of EMI and MAN in vitro. In addition, was evaluate the effect on the mRNA expression of genes (CB1, PPARγ, adiponectin, resistin and leptin) associated with adipogenesis in adipose tissue of rats fed a cafeteria diet. Thus, wistar rats were treated by gavage with EMI and MAN for several days (according to the post and co-treatments). The adipose tissue was weighed and checked the expression of different markers by RT-PCR. The presence of MAN as major compound in EMI was verified. Both EMI and MAN were not cytotoxic, with lower EMI expression of TNF-α. Furthermore, EMI and MAN had proadipogenic action on post-treatment, while in the co-treatment, EMI attenuated the effect of adipogenesis and MAN increased the adipogenic process.Graphical abstractGraphical abstract for this article
       
  • Encapsulation and stability of a phenolic-rich extract from mango peel
           within water-in-oil-in-water emulsions
    • Abstract: Publication date: May 2019Source: Journal of Functional Foods, Volume 56Author(s): Gustavo R. Velderrain-Rodríguez, Alejandra Acevedo-Fani, Gustavo A. González-Aguilar, Olga Martín-BellosoMango peel is an excellent source of compounds with nutritional and functional properties, especially phenolic compounds (PC). However, it is usually discarded due to its unpleasant taste and its difficulty to be added to food products. As a solution, we evaluated the feasibility of encapsulating a phenolic-rich extract from mango peel (MPPE) within water-in-oil-in-water (W1/O/W2) emulsions, using different surfactants (Tween 20, Tween 80 and lecithin). Time and amplitude conditions of ultrasound treatment were evaluated to form the MPPE loaded water-in-oil (W/O) emulsions, using polyglycerol polyricinoleate (PGPR) as a surfactant. Regarding of W1/O/W2 emulsions, the highest encapsulation efficiency (EE) was observed in those with Tween 20 and lecithin (98.65 ± 1.14% and 96.11 ± 1.37%, respectively). However, emulsions with Tween 80 had the best physical and encapsulation stability (ES) during storage. These results demonstrate that PC can be successfully encapsulated within efficient and stable emulsion-based systems by selecting the appropriate surfactants.Graphical abstractGraphical abstract for this article
       
  • Protective mechanism of punicalagin against endoplasmic reticulum stress
           in the liver of mice with type 2 diabetes mellitus
    • Abstract: Publication date: May 2019Source: Journal of Functional Foods, Volume 56Author(s): Fang-fang Mo, Bo-han Lv, Tian An, Jia-nan Miao, Jia-xian Liu, Jing Zhang, Zhi-yong Zhang, Meng-hua Ma, Xiu-yan Yang, Dan-dan Zhao, Dong-wei Zhang, Si-hua Gao, Guang-jian JiangTo develop a more effective and safer drug for the treatment of type 2 diabetes mellitus (T2DM)-induced liver damage, we investigated the protective effects of punicalagin, a major component in pomegranate peel, on the liver of mice with T2DM. After five weeks of punicalagin treatment, blood and liver samples were obtained for the subsequent analyses. Western blotting, reverse transcription polymerase chain reaction, and immunohistochemical staining were performed to determine the expression of endoplasmic reticulum (ER) stress markers in the liver tissue. The results showed that punicalagin alleviated glucose and insulin resistance, increased insulin sensitivity, and reduced serum free fatty acids levels and hepatic steatosis in the mice with T2DM. Furthermore, punicalagin down-regulated the elevated mRNA expression of the ER stress markers eIF2α, GRP78, ATF4, and CHOP in the liver of mice with T2DM. Our results suggest that punicalagin is a potential natural agent for the prevention of T2DM-induced liver damage.Graphical abstractGraphical abstract for this article
       
  • Effect of piceatannol on circadian Per2 expression in
           vitro
    and in vivo
    • Abstract: Publication date: May 2019Source: Journal of Functional Foods, Volume 56Author(s): Takayuki Yamamoto, Shiho Iwami, Shinya Aoyama, Hiroko Maruki-Uchida, Sadao Mori, Rina Hirooka, Kengo Takahashi, Minoru Morita, Shigenobu ShibataIn addition to the development of chrononutrition, food ingredients have been demonstrated to contribute to expression changes in the peripheral clock genes responsible for circadian rhythms. Passion fruit seeds extract (PFSE) contains a high concentration of piceatannol that exhibits many physiological activities; however, whether PFSE and piceatannol affect clock genes is not known with certainty. In this study, we evaluated the effects of PFSE and piceatannol on the rhythm of PER2 using bioluminescence in mPer2Luc knock-in mice and their embryonic fibroblasts. Piceatannol was demonstrated to advance and delay the phase of PER2::LUC oscillation owing to differences in timing of treatment in vitro. In the in vivo imaging system, oral administration of piceatannol significantly advanced the luminescence rhythm of PER2::LUC in peripheral organs. Furthermore, piceatannol recovered the phase change of PER2::LUC disturbed by high-fat diet intake. These findings indicate that piceatannol affects peripheral clock gene expression and may prevent circadian disturbance.Graphical abstractGraphical abstract for this article
       
  • Daily consumption of a dark-roast coffee for eight weeks improved plasma
           oxidized LDL and alpha-tocopherol status: A randomized, controlled human
           intervention study
    • Abstract: Publication date: May 2019Source: Journal of Functional Foods, Volume 56Author(s): Christina M. Hochkogler, Kerstin Schweiger, Petra Rust, Marc Pignitter, Johanna Rathmayr, Sebastian Bayer, Christina Chmelirsch, Leonie Hüller, Doris Marko, Roman Lang, Thomas Hofmann, Andrea Christina Kurz, Gerhard Bytof, Ingo Lantz, Dorothea Schipp, Veronika SomozaScopeCoffee consumption is widely recognized to improve the antioxidant status. We hypothesized a dark-roast coffee to reduce plasma oxidized LDL (oxLDL) and to improve alpha-tocopherol concentrations.Methods and resultsAfter a 4 week, coffee-free run-in period, 86 healthy, randomized volunteers completed either a control (CTRL) or coffee (COFF) intervention in which either 750 mL water (CTRL) or coffee (COFF) were consumed daily for 8 weeks. Blood samples were taken at the begin and after the intervention. Mean changes in oxidized LDL concentrations after coffee consumption (−0.47 ± 15.4 U/L) differed from those of the CTRL-G (5.69 ± 18.8 U/L, p 
       
  • Oat fiber inhibits atherosclerotic progression through improving lipid
           metabolism in ApoE−/− mice
    • Abstract: Publication date: May 2019Source: Journal of Functional Foods, Volume 56Author(s): Shufen Han, Ru Zhang, Hui Gao, Jing Yang, Weiguo Zhang, Liqiang QinCardiovascular diseases caused by atherosclerosis have become one of the leading cause of death. The aim of the present study was to explore how oat fiber regulated lipid metabolism and to elucidate its anti-atherosclerotic potential in ApoE−/− mice. Animals were daily fed a high-fat diet without or with 0.8% oat fiber for 18 weeks. Both serum total cholesterol and low-density cholesterol levels decreased in mice received oat fiber administration than those without Oat fiber inhibited hepatic lipid accumulation by downregulating SREBP-1 expression and accelerated clearance of intestinal cholesterol by upregulating SREBP-2 expression. In addition, oat fiber activated cholesterol sensors LXRα, and then strengthened hepatic and intestinal cholesterol efflux by increasing ATP-binding cassette A1 and G1, and decreased intestinal cholesterol absorption by inhibiting Niemann pick C 1 like 1. The findings implicated that oat fiber had an anti-atherosclerotic potential via mechanisms of activating the SREBPs/LXRα pathway and improving lipid metabolism.Graphical abstractGraphical abstract for this article
       
  • Quercetin confers protection of murine sepsis by inducing macrophage M2
           polarization via the TRPM2 dependent calcium influx and AMPK/ATF3
           activation
    • Abstract: Publication date: May 2019Source: Journal of Functional Foods, Volume 56Author(s): Yuanfeng Zhu, Shijun Fan, Yongling Lu, Yan Wei, Ju Tang, Yongjun Yang, Fangfang Li, Qian Chen, Jiang Zheng, Xin LiuM2 macrophage polarization plays a crucial role in counteracting inflammatory disorders such as sepsis. Quercetin is a dietary flavonoid that possesses robust anti-inflammatory properties. However, it is not known whether quercetin takes effects by directly promoting M2 polarization in macrophages. In this study, we observed that quercetin enhanced macrophage M2 polarization and exerted anti-inflammatory activity in LPS stimulated murine peritoneal macrophages. Moreover, quercetin triggered TRPM2 dependent calcium influx and induced calcium dependent activation of AMPKα and ATF3, both were required to mediate M2 macrophage polarization and facilitate the anti-inflammatory activity by quercetin. In a murine endotoxaemia model, quercetin improved survival and ameliorated acute lung injury. Quercetin also induced AMPKα phosphorylation, upregulated ATF3 expression and promoted M2 macrophage polarization in model mice. In conclusion, our results suggest that quercetin promotes macrophage M2 polarization and confers protection of murine sepsis by inducing calcium dependent activation of the AMPK-ATF3 pathway.Graphical abstractGraphical abstract for this article
       
  • Medicinal importance of mushroom mycelium: Mechanisms and applications
    • Abstract: Publication date: May 2019Source: Journal of Functional Foods, Volume 56Author(s): Himanshi Rathore, Shalinee Prasad, Mandira Kapri, Abhay Tiwari, Satyawati SharmaMushroom fruiting bodies have been used as food and food-flavouring materials for centuries for their unique and subtle flavour. However, the whole cycle from mycelium colonization to the fruit-body formation is time-consuming and involves extensive labour. Submerged cultivation of fungi can be a promising alternative for obtaining potent substances for successful utilization in the composition of functional foods. Submerged culture is a speedy process that yields quality mushroom mycelia, considering the alternative of cultivation that takes much more time to produce fruiting bodies. Moreover, the culturing of mycelia on synthetic media is a convenient approach to obtain fungal biomass. Presence of bioactive components in mushroom mycelium makes it an attractive ingredient that is now used as dietary supplements or nutraceuticals. This review focuses on the optimum growth conditions required by mycelia for enhanced quality and yield prospects along with the biological mechanisms responsible for their therapeutic properties and their applications.Graphical abstractGraphical abstract for this article
       
  • Design of low glycemic response foods using polyphenols from seaweed
    • Abstract: Publication date: May 2019Source: Journal of Functional Foods, Volume 56Author(s): Javier Parada, José R. Pérez-Correa, Jara Pérez-JiménezSeveral aspects of foods affect starch digestion and glycemic response, including food’s physical/chemical structure and the presence of anti-enzymatic compounds. The complex relationship between food properties, metabolism and diseases implies that designing foods with a consistent lower glycemic response turn challenging. Edible seaweeds are rich in several bioactive compounds -particularly polyphenols-, which can be used to develop new low glycemic response foods. This paper reviews what is known about functional ingredients found in seaweeds that may help to design lower glycemic response foods through mainly the inhibition of digestive enzymes related with the breakdown of glycemic carbohydrates. A global viewpoint is exposed, covering aspects related with seaweed’s polyphenols composition and application of such compounds to design new products.Graphical abstractGraphical abstract for this article
       
  • Lactobacillus fermentum and its potential immunomodulatory
           properties
    • Abstract: Publication date: May 2019Source: Journal of Functional Foods, Volume 56Author(s): Yan Zhao, Kan Hong, Jianxin Zhao, Hao Zhang, Qixiao Zhai, Wei ChenLactobacillus fermentum has been used in industrial processes and food fermentation for a long time. Because it is of human origin, non-pathogenic, has high resistance to passing through the intestine, prevents pathogenic insults and promotes the maturation of the immune system, it has been identified as a potential probiotic. L. fermentum has been shown to interact with human immune cells and to modulate specific pathways involved in innate and adaptive immune processes in diverse inflammatory diseases. This review summarizes the immunomodulatory properties and regulatory mechanisms of L. fermentum identified in isolated immune cells, animal models and the human body in recent studies.Graphical abstractL. fermentum participates in immune regulation.Many L. fermentum have demonstrated capacity to promote a Th1 response and participated in the regulation of a series of inflammatory cytokines in inflammatory diseases. Immunomodulatory properties are strain-dependent, and further evidence is needed in order to give to each L. fermentum a specific immune response in the intestinal mucosa.Graphical abstract for this article
       
 
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