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Journal Cover Nature Communications
  [SJR: 5.682]   [H-I: 56]   [96 followers]  Follow
  This is an Open Access Journal Open Access journal
   ISSN (Online) 2041-1723
   Published by Nature Publishing Group Homepage  [117 journals]
  • Ultraflexible organic amplifier with biocompatible gel electrodes

    • Authors: Tsuyoshi Sekitani, Tomoyuki Yokota, Kazunori Kuribara, Martin Kaltenbrunner, Takanori Fukushima, Yusuke Inoue, Masaki Sekino, Takashi Isoyama, Yusuke Abe, Hiroshi Onodera, Takao Someya
      Abstract: Flexible electronics promise the opportunity to monitor biological activity via implanted devices. Here, the authors develop a biocompatible conductive carbon nanotube/gel composite and couple it with an ultrathin flexible amplifier, enabling in vivo measurement of epicardial electrocardiogram signals.
      Citation: Nature Communications
      PubDate: 2016-04-29|2016-04-29
      DOI: 10.1038/ncomms11425
  • Asparagine promotes cancer cell proliferation through use as an amino acid
           exchange factor

    • Authors: Abigail S. Krall, Shili Xu, Thomas G. Graeber, Daniel Braas, Heather R. Christofk
      Abstract: Cancer cells have been shown to be dependent upon glutamine for growth. Here, the authors show that intracellular asparagine, a glutamine-derived metabolite, is critical to cancer cell growth and can compensate glutamine deficiency by acting as an amino acid exchange factor.
      Citation: Nature Communications
      PubDate: 2016-04-29|2016-04-29
      DOI: 10.1038/ncomms11457
  • Mode engineering for realistic quantum-enhanced interferometry

    • Abstract: Quantum interferometry suffers from residual distinguishability between input photons. Here, the authors show theoretically and experimentally, in a two-photon measurement, how to overcome this by manipulating additional degrees of freedom.
      Citation: Nature Communications
      PubDate: 2016-04-29|2016-04-29
      DOI: 10.1038/ncomms11411
  • RhoA determines lineage fate of mesenchymal stem cells by modulating
           CTGF–VEGF complex in extracellular matrix

    • Authors: Changjun Li, Gehua Zhen, Yu Chai, Liang Xie, Janet L. Crane, Emily Farber, Charles R. Farber, Xianghang Luo, Peisong Gao, Xu Cao, Mei Wan
      Abstract: It is unclear what regulates the fate of mesenchymal stem cells (MSCs) in arterial repair following injury. Here, the authors show that MSC differentiation following injury is triggered by RhoA which in turn stimulates the release of connective tissue growth factor and vascular endothelial growth factor.
      Citation: Nature Communications
      PubDate: 2016-04-29|2016-04-29
      DOI: 10.1038/ncomms11455
  • Converging flow and anisotropy cause large-scale folding in Greenland's
           ice sheet

    • Authors: Paul D. Bons, Daniela Jansen, Felicitas Mundel, Catherine C. Bauer, Tobias Binder, Olaf Eisen, Mark W. Jessell, Maria-Gema Llorens, Florian Steinbach, Daniel Steinhage, Ilka Weikusat
      Abstract: A range of mechanisms has been proposed for large-scale folding in polar ice sheets. Here, using new three-dimensional reconstructions of such folds in the onset region of the Greenland Petermann Glacier, the authors show that these formed due to flow convergence and the high mechanical anisotropy of ice.
      Citation: Nature Communications
      PubDate: 2016-04-29|2016-04-29
      DOI: 10.1038/ncomms11427
  • Expression of a functional oxygen-labile nitrogenase component in the
           mitochondrial matrix of aerobically grown yeast

    • Abstract: The sensitivity of nitrogenase to oxygen is a major barrier to engineer biological nitrogen fixation into cereal crops by direct nif gene transfer. Here the authors use yeast to show that targeting nitrogenase Fe protein to the mitochondrial matrix overcomes the O 2 sensitivity impediment.
      Citation: Nature Communications
      PubDate: 2016-04-29|2016-04-29
      DOI: 10.1038/ncomms11426
  • Functionalization mediates heat transport in graphene nanoflakes

    • Abstract: The high thermal conductivity of graphene is considerably reduced when the two-dimensional material is in contact with a substrate. Here, the authors show that thermal management of a micro heater is improved using graphene-based films covalently bonded by amino-silane molecules to graphene oxide.
      Citation: Nature Communications
      PubDate: 2016-04-29|2016-04-29
      DOI: 10.1038/ncomms11281
  • Clks 1, 2 and 4 prevent chromatin breakage by regulating the Aurora
           B-dependent abscission checkpoint

    • Authors: Eleni Petsalaki, George Zachos
      Abstract: Cells delay completion of cytokinesis when chromatin is trapped at the intercellular bridge. Here, Petsalaki and Zachos report that Cdc-like kinases (Clks) 1, 2 and 4 localize to the midbody and phosphorylate the mitotic kinase Aurora B, imposing the abscission checkpoint to prevent premature abscission and chromatin breakage.
      Citation: Nature Communications
      PubDate: 2016-04-29|2016-04-29
      DOI: 10.1038/ncomms11451
  • Quantum Einstein-de Haas effect

    • Authors: Marc Ganzhorn, Svetlana Klyatskaya, Mario Ruben, Wolfgang Wernsdorfer
      Abstract: The Einstein-de Haas effect is a manifestation of the conservation of angular momentum, causing a magnetic object to rotate as its magnetization state is changed. Here, the authors demonstrate this effect at the single spin level for a molecular magnet suspended on a nanomechanical resonator.
      Citation: Nature Communications
      PubDate: 2016-04-29|2016-04-29
      DOI: 10.1038/ncomms11443
  • Myoscape controls cardiac calcium cycling and contractility via regulation
           of L-type calcium channel surface expression

    • Abstract: Heart failure is a major public health issue but due to our poor disease understanding the current therapies are symptomatic. Here the authors identify Myoscape as a novel cardiac protein regulating membrane localization of the L-type calcium channel and heart's contractile force, thus promising new therapeutic avenues for heart failure.
      Citation: Nature Communications
      PubDate: 2016-04-28|2016-04-28
  • Structural basis of oncogenic histone H3K27M inhibition of human polycomb
           repressive complex 2

    • Authors: Neil Justin, Ying Zhang, Cataldo Tarricone, Stephen R. Martin, Shuyang Chen, Elizabeth Underwood, Valeria De Marco, Lesley F. Haire, Philip A. Walker, Danny Reinberg, Jon R. Wilson, Steven J. Gamblin
      Abstract: Polycomb repressive complex 2 (PRC2) silences gene expression through trimethylation of K27 of histone H3 (H3K27Me). Here, the authors report the structure of the human PRC2 complex bound to the oncogenic H3K27M mutant, and suggest a mechanism for its potency in childhood brain cancers.
      Citation: Nature Communications
      PubDate: 2016-04-28|2016-04-28
      DOI: 10.1038/ncomms11316
  • Imaging large-scale cellular activity in spinal cord of freely behaving

    • Authors: Kohei J. Sekiguchi, Pavel Shekhtmeyster, Katharina Merten, Alexander Arena, Daniela Cook, Elizabeth Hoffman, Alexander Ngo, Axel Nimmerjahn
      Abstract: Imaging cellular activity in mouse spinal cord has been historically difficult. Here the authors develop cellular resolution fluorescence imaging approaches in the spinal cord of behaving mice, and report distinct activity patterns of neurons and astrocytes in response to different sensory inputs.
      Citation: Nature Communications
      PubDate: 2016-04-28|2016-04-28
      DOI: 10.1038/ncomms11450
  • DNMT3B isoforms without catalytic activity stimulate gene body methylation
           as accessory proteins in somatic cells

    • Authors: Christopher E. Duymich, Jessica Charlet, Xiaojing Yang, Peter A. Jones, Gangning Liang
      Abstract: De novo DNA methylation is carried out by DNA methyltransferase DNMT3A/B, although DNMT3B isoforms without active catalytic domains are widely expressed. Here, the authors show that DNMT3B isoforms stimulate gene body methylation and re-methylation independently of the isoforms' catalytic activity.
      Citation: Nature Communications
      PubDate: 2016-04-28|2016-04-28
      DOI: 10.1038/ncomms11453
  • An essential malaria protein defines the architecture of blood-stage and
           transmission-stage parasites

    • Authors: Sabrina Absalon, Jonathan A. Robbins, Jeffrey D. Dvorin
      Abstract: Blood-stage malaria parasites replicate through a specialised type of cell division known as schizogony. Here, Absalon et al . identify a parasite protein that is essential during schizogony for cytokinesis and formation of the inner membrane complex, the structural scaffold of daughter parasites.
      Citation: Nature Communications
      PubDate: 2016-04-28|2016-04-28
      DOI: 10.1038/ncomms11449
  • Trapping mammalian protein complexes in viral particles

    • Authors: Sven Eyckerman, Kevin Titeca, Emmy Van Quickelberghe, Eva Cloots, Annick Verhee, Noortje Samyn, Leentje De Ceuninck, Evy Timmerman, Delphine De Sutter, Sam Lievens, Serge Van Calenbergh, Kris Gevaert, Jan Tavernier
      Abstract: A large portion of the proteome carries out its cellular function as part of macromolecular complexes. Here the authors describe Virotrap, a novel lysis-free approach for the isolation and identification of biologically relevant protein-protein and small molecule-protein interactions.
      Citation: Nature Communications
      PubDate: 2016-04-28|2016-04-28
      DOI: 10.1038/ncomms11416
  • Polycomb repressive complex 2 structure with inhibitor reveals a mechanism
           of activation and drug resistance

    • Abstract: Polycomb repressive complex 2 (PRC2) mediates gene silencing through chromatin reorganization by methylation of histone H3 lysine 27 (H3K27). Here, the authors present crystal structures of the inhibitor-bound wild-type and a mutant form of PRC2.
      Citation: Nature Communications
      PubDate: 2016-04-28|2016-04-28
      DOI: 10.1038/ncomms11384
  • A cell cycle kinase with tandem sensory PAS domains integrates cell fate

    • Authors: Thomas H. Mann, W. Seth Childers, Jimmy A. Blair, Michael R. Eckart, Lucy Shapiro
      Abstract: The membrane-bound kinase CckA controls the activity of the Caulobacter crescentus master regulator CtrA, which in turn coordinates asymmetric cell division. Here, the authors show that CckA contains two sensory domains that have distinct sensitivities to fluctuations in cyclic-di-GMP concentration and subcellular niche.
      Citation: Nature Communications
      PubDate: 2016-04-27|2016-04-27
      DOI: 10.1038/ncomms11454
  • NMDA receptors are selectively partitioned into complexes and
           supercomplexes during synapse maturation

    • Abstract: NMDARs and MAGUK proteins are capable of forming higher-order protein assemblies, however their organisation in the intact brain is unclear. Here, Frank et al . identify mouse and human supercomplexes and discover their mechanism of assembly using genetic tagging and affinity purification.
      Citation: Nature Communications
      PubDate: 2016-04-27|2016-04-27
      DOI: 10.1038/ncomms11264
  • Corrigendum: Growth of semiconducting single-wall carbon nanotubes with a
           narrow band-gap distribution

    • Authors: Feng Zhang, Peng-Xiang Hou, Chang Liu, Bing-Wei Wang, Hua Jiang, Mao-Lin Chen, Dong-Ming Sun, Jin-Cheng Li, Hong-Tao Cong, Esko I. Kauppinen, Hui-Ming Cheng
      Citation: Nature Communications
      PubDate: 2016-04-27|2016-04-27
      DOI: 10.1038/ncomms11563
  • Epigenetic profiles signify cell fate plasticity in unipotent
           spermatogonial stem and progenitor cells

    • Authors: Ying Liu, Eugenia G. Giannopoulou, Duancheng Wen, Ilaria Falciatori, Olivier Elemento, C. David Allis, Shahin Rafii, Marco Seandel
      Abstract: Spermatogonial stem cells (SSCs) spontaneously convert to multipotent adult spermatogonial-derived stem cells (MASCs). Here, the authors reveal the dynamics of bivalent histone H3-lysine4 and -lysine27 methylation signatures at somatic gene promoters in SSCs and ESC-like promoter chromatin states in MASCs.
      Citation: Nature Communications
      PubDate: 2016-04-27|2016-04-27
      DOI: 10.1038/ncomms11275
  • Homotypic cell competition regulates proliferation and tiling of zebrafish
           pigment cells during colour pattern formation

    • Abstract: Melanophores, iridophores and xanthophores are pigment-cell types that interact to form the stripes in zebrafish. Here, the authors study the interaction between cells of the same kind and show that each pigment-cell type covers the skin by contact based competition.
      Citation: Nature Communications
      PubDate: 2016-04-27|2016-04-27
      DOI: 10.1038/ncomms11462
  • Sn-doped Bi1.1Sb0.9Te2S bulk crystal topological insulator with excellent

    • Abstract: An ideal topological insulator possesses an insulating bulk and a unique conducting surface however such behaviour is typically inhibited by bulk conduction due to defects. Here, the authors show that Sn-doped Bi 1.1 Sb 0.9 Te 2 S grown by the vertical Bridgman technique might overcome this hurdle.
      Citation: Nature Communications
      PubDate: 2016-04-27|2016-04-27
      DOI: 10.1038/ncomms11456
  • Identification of four novel susceptibility loci for oestrogen receptor
           negative breast cancer

    • Abstract: Oestrogen negative breast cancer is associated with a poor prognosis. In this study, the authors perform a meta-analysis of 11 breast cancer genome-wide association studies and identify four new loci associated with oestrogen negative breast cancer risk. These findings may aid in stratifying patients in the clinic.
      Citation: Nature Communications
      PubDate: 2016-04-27|2016-04-27
      DOI: 10.1038/ncomms11375
  • Optical painting and fluorescence activated sorting of single adherent
           cells labelled with photoswitchable Pdots

    • Authors: Chun-Ting Kuo, Alison M. Thompson, Maria Elena Gallina, Fangmao Ye, Eleanor S. Johnson, Wei Sun, Mengxia Zhao, Jiangbo Yu, I-Che Wu, Bryant Fujimoto, Christopher C. DuFort, Markus A. Carlson, Sunil R. Hingorani, Amy L. Paguirigan, Jerald P. Radich, Daniel T. Chiu
      Abstract: Isolation of individual cells from mixed populations is desirable for many biomedical applications. Here the authors use photoswitchable Pdots to allow 'optical painting', where cells of interest are marked based on their visual characteristics, and can then be isolated by fluorescence activated cell sorting.
      Citation: Nature Communications
      PubDate: 2016-04-27|2016-04-27
      DOI: 10.1038/ncomms11468
  • Exosomal microRNA miR-92a concentration in serum reflects human brown fat

    • Authors: Yong Chen, Joschka J. Buyel, Mark J. W. Hanssen, Franziska Siegel, Ruping Pan, Jennifer Naumann, Michael Schell, Anouk van der Lans, Christian Schlein, Holger Froehlich, Joerg Heeren, Kirsi A. Virtanen, Wouter van Marken Lichtenbelt, Alexander Pfeifer
      Abstract: Exosomes are RNA-containing lipid vesicles with roles in inter-tissue crosstalk. Here the authors show that exosome release from brown adipocytes is increased upon thermogenic activation, both in vitro and in vivo , and demonstrate that serum levels of exosomal miR-92 reflect brown fat activity in humans.
      Citation: Nature Communications
      PubDate: 2016-04-27|2016-04-27
      DOI: 10.1038/ncomms11420
  • Line tension at lipid phase boundaries as driving force for HIV fusion
           peptide-mediated fusion

    • Authors: Sung-Tae Yang, Volker Kiessling, Lukas K. Tamm
      Abstract: HIV preferentially fuses with lipid membranes at the interface between ordered and disordered domains, but the mechanistic basis for this observation is not known. Here Yang et al . show that line tension at the lipid boundary contributes considerable energy to drive gp41 fusion peptide-mediated fusion.
      Citation: Nature Communications
      PubDate: 2016-04-26|2016-04-26
      DOI: 10.1038/ncomms11401
  • Highly selective hydrogenation of arenes using nanostructured ruthenium
           catalysts modified with a carbon–nitrogen matrix

    • Abstract: The selective reduction of arenes is important in organic synthesis and also valorization of biomass. Here, the authors report the use of ruthenium-based nanoparticles, which display high activity in arene reduction and preferentially hydrogenate aromatic rings rather than cleaving etheric C-O bonds.
      Citation: Nature Communications
      PubDate: 2016-04-26|2016-04-26
      DOI: 10.1038/ncomms11326
  • Protein-directed self-assembly of a fullerene crystal

    • Authors: Kook-Han Kim, Dong-Kyun Ko, Yong-Tae Kim, Nam Hyeong Kim, Jaydeep Paul, Shao-Qing Zhang, Christopher B. Murray, Rudresh Acharya, William F. DeGrado, Yong Ho Kim, Gevorg Grigoryan
      Abstract: Self-assembly enables complex structures to be fabricated from a few relatively simple components, but requires a detailed understanding of how the constituents may interact. Here, the authors report the rational assembly and crystallographic characterization of a fullerene-protein superstructure.
      Citation: Nature Communications
      PubDate: 2016-04-26|2016-04-26
      DOI: 10.1038/ncomms11429
  • Elasticity-induced force reversal between active spinning particles in
           dense passive media

    • Authors: J. L. Aragones, J. P. Steimel, A. Alexander-Katz
      Abstract: Physics out-of-equilibrium is necessary to understand a variety of interactions, for example in biological systems. Here, the authors show that the interactions between non-Brownian active spinning particles can change from repulsive to attractive depending on the properties of the surrounding passive medium.
      Citation: Nature Communications
      PubDate: 2016-04-26|2016-04-26
      DOI: 10.1038/ncomms11325
  • All-optical design for inherently energy-conserving reversible gates and

    • Authors: Eyal Cohen, Shlomi Dolev, Michael Rosenblit
      Abstract: Reversible gates, like Fredkin gates, may be useful for energy conservation efforts. Cohen et al . present a formalism that may be used to produce any reversible logic. This method is implemented over an optical design of the Fredkin gate which utilizes only optical elements that inherently conserve energy.
      Citation: Nature Communications
      PubDate: 2016-04-26|2016-04-26
      DOI: 10.1038/ncomms11424
  • Diverse human extracellular RNAs are widely detected in human plasma

    • Authors: Jane E. Freedman, Mark Gerstein, Eric Mick, Joel Rozowsky, Daniel Levy, Robert Kitchen, Saumya Das, Ravi Shah, Kirsty Danielson, Lea Beaulieu, Fabio C. P. Navarro, Yaoyu Wang, Timur R. Galeev, Alex Holman, Raymond Y. Kwong, Venkatesh Murthy, Selim E. Tanriverdi, Milka Koupenova-Zamor, Ekaterina Mikhalev, Kahraman Tanriverdi
      Abstract: Extracellular miRNAs are present in a variety of bodily fluids. Here, Freedman et al . analysed plasma-derived RNA by RNA-seq from 40 people followed by targeted RT-qPCR in an additional 2,763 people, and report over 1,000 extracellular RNAs including microRNAs, piwi-interacting RNA and small nucleolar RNAs.
      Citation: Nature Communications
      PubDate: 2016-04-26|2016-04-26
      DOI: 10.1038/ncomms11106
  • Erratum: Oxygen depletion recorded in upper waters of the glacial Southern

    • Authors: Zunli Lu, Babette A. A. Hoogakker, Claus-Dieter Hillenbrand, Xiaoli Zhou, Ellen Thomas, Kristina M. Gutchness, Wanyi Lu, Luke Jones, Rosalind E. M. Rickaby
      Citation: Nature Communications
      PubDate: 2016-04-26|2016-04-26
      DOI: 10.1038/ncomms11531
  • Strong nonlinear terahertz response induced by Dirac surface states in
           Bi2Se3 topological insulator

    • Authors: Flavio Giorgianni, Enrica Chiadroni, Andrea Rovere, Mariangela Cestelli-Guidi, Andrea Perucchi, Marco Bellaveglia, Michele Castellano, Domenico Di Giovenale, Giampiero Di Pirro, Massimo Ferrario, Riccardo Pompili, Cristina Vaccarezza, Fabio Villa, Alessandro Cianchi, Andrea Mostacci, Massimo Petrarca, Matthew Brahlek, Nikesh Koirala, Seongshik Oh, Stefano Lupi
      Abstract: The terahertz response of topological insulator surface states, in which relativistic electrons are protected from backscattering, possesses potential optic and plasmonic applications. Here, the authors demonstrate a nonlinear absorption response of Bi 2 Se 3 to terahertz electric fields.
      Citation: Nature Communications
      PubDate: 2016-04-26|2016-04-26
      DOI: 10.1038/ncomms11421
  • Neural substrates of cognitive biases during probabilistic inference

    • Authors: Alireza Soltani, Peyman Khorsand, Clara Guo, Shiva Farashahi, Janet Liu
      Abstract: Humans are often biased in estimating the precise influence of probabilistic events on their decisions. Here, Khorsand and colleagues report a behavioural task that produces these biases in inference and describe a biophysically-plausible model that captures these behavioural deviations from optimal decision making.
      Citation: Nature Communications
      PubDate: 2016-04-26|2016-04-26
      DOI: 10.1038/ncomms11393
  • miR-22 has a potent anti-tumour role with therapeutic potential in acute
           myeloid leukaemia

    • Authors: Xi Jiang, Chao Hu, Stephen Arnovitz, Jason Bugno, Miao Yu, Zhixiang Zuo, Ping Chen, Hao Huang, Bryan Ulrich, Sandeep Gurbuxani, Hengyou Weng, Jennifer Strong, Yungui Wang, Yuanyuan Li, Justin Salat, Shenglai Li, Abdel G. Elkahloun, Yang Yang, Mary Beth Neilly, Richard A. Larson, Michelle M. Le Beau, Tobias Herold, Stefan K. Bohlander, Paul P. Liu, Jiwang Zhang, Zejuan Li, Chuan He, Jie Jin, Seungpyo Hong, Jianjun Chen
      Abstract: Mir-22 has been shown to be an oncogenic microRNA in breast cancer and myelodysplastic syndrome. Here, the authors show that mir-22 functions as a tumour suppressor in de novo acute myeloid leukaemia by inhibiting the expression of several oncogenes and that restoring mir-22 expression suppresses AML progression.
      Citation: Nature Communications
      PubDate: 2016-04-26|2016-04-26
      DOI: 10.1038/ncomms11452
  • An inhibitor of chondroitin sulfate proteoglycan synthesis promotes
           central nervous system remyelination

    • Authors: Michael B. Keough, James A. Rogers, Ping Zhang, Samuel K. Jensen, Erin L. Stephenson, Tieyu Chen, Mitchel G. Hurlbert, Lorraine W. Lau, Khalil S. Rawji, Jason R. Plemel, Marcus Koch, Chang-Chun Ling, V. Wee Yong
      Abstract: Chondroitin sulfate proteoglycans (CSPGs) secreted by astrocytes are known to inhibit OPC differentiation and remyelination. Here, the authors identify a novel CSPG synthesis inhibitor and find it can rescue OPC differentiation in vitro and accelerate remyelination in mice following focal demyelination.
      Citation: Nature Communications
      PubDate: 2016-04-26|2016-04-26
      DOI: 10.1038/ncomms11312
  • Network dynamics in nanofilled polymers

    • Authors: Guilhem P. Baeza, Claudia Dessi, Salvatore Costanzo, Dan Zhao, Shushan Gong, Angel Alegria, Ralph H. Colby, Michael Rubinstein, Dimitris Vlassopoulos, Sanat K. Kumar
      Abstract: The mixture of nanoparticles and polymers can dramatically alter the dynamics of the resulting system, but the detail is still under debate. Here, Baeza et al . show the formation of a percolated network by polymer bridging between adjacent nanoparticles as nanoparticle concentration increases.
      Citation: Nature Communications
      PubDate: 2016-04-25|2016-04-25
      DOI: 10.1038/ncomms11368
  • Dysregulation of miRNAs-COUP-TFII-FOXM1-CENPF axis contributes to the
           metastasis of prostate cancer

    • Authors: Shih-Chieh Lin, Chung-Yang Kao, Hui-Ju Lee, Chad J. Creighton, Michael M. Ittmann, Shaw-Jenq Tsai, Sophia Y. Tsai, Ming-Jer Tsai
      Abstract: The orphan nuclear receptor COUP-TFII is highly expressed in metastatic prostate cancers and its overexpression accelerates prostate tumour progression in mouse models. Here, the author show that that loss of miR-101 and miR-27a in prostate cancer cells can lead to COUP-TFII expression which in turn directly regulates FOXM1 and CENPF favouring prostate cancer metastasis.
      Citation: Nature Communications
      PubDate: 2016-04-25|2016-04-25
      DOI: 10.1038/ncomms11418
  • Contrasting effects of defaunation on aboveground carbon storage across
           the global tropics

    • Authors: Anand M. Osuri, Jayashree Ratnam, Varun Varma, Patricia Alvarez-Loayza, Johanna Hurtado Astaiza, Matt Bradford, Christine Fletcher, Mireille Ndoundou-Hockemba, Patrick A. Jansen, David Kenfack, Andrew R. Marshall, B. R. Ramesh, Francesco Rovero, Mahesh Sankaran
      Abstract: Defaunation is linked to the decline of tree species that depend on large animals for seed dispersal, but it is unclear if this affects carbon storage. Here the authors show that defaunation effects on carbon storage vary across continents, driven by relationships between seed dispersal strategies and adult tree size.
      Citation: Nature Communications
      PubDate: 2016-04-25|2016-04-25
      DOI: 10.1038/ncomms11351
  • Phosphotransferase-dependent accumulation of (p)ppGpp in response to
           glutamine deprivation in Caulobacter crescentus

    • Abstract: The small molecule (p)ppGpp is commonly produced by bacteria as a signal of nutrient starvation. Here, Ronneau et al . show that (p)ppGpp accumulation in the model bacterium Caulobacter crescentus is modulated by a nitrogen-related phosphotransferase system in response to glutamine deprivation.
      Citation: Nature Communications
      PubDate: 2016-04-25|2016-04-25
      DOI: 10.1038/ncomms11423
  • Insights into the activation mechanism of class I HDAC complexes by
           inositol phosphates

    • Authors: Peter J. Watson, Christopher J. Millard, Andrew M. Riley, Naomi S. Robertson, Lyndsey C. Wright, Himali Y. Godage, Shaun M. Cowley, Andrew G. Jamieson, Barry V. L. Potter, John W. R. Schwabe
      Abstract: Class I histone deacetylase complexes can be activated by inositol phosphates. Here, the authors investigate the stereochemical requirements for activation; use the crystal structure to understand substrate recognition, and suggest an entropically driven mechanism of allostery.
      Citation: Nature Communications
      PubDate: 2016-04-25|2016-04-25
      DOI: 10.1038/ncomms11262
  • miRNA863-3p sequentially targets negative immune regulator ARLPKs and
           positive regulator SERRATE upon bacterial infection

    • Authors: Dongdong Niu, Yifan E. Lii, Padmanabhan Chellappan, Lei Lei, Karl Peralta, Chunhao Jiang, Jianhua Guo, Gitta Coaker, Hailing Jin
      Abstract: Small RNA plays an important role in regulating the plant defence against bacterial pathogens. Here the authors propose that miR863-3p acts to fine-tune the timing of defence responses by sequentially silencing negative and positive regulators of the plant immune response.
      Citation: Nature Communications
      PubDate: 2016-04-25|2016-04-25
      DOI: 10.1038/ncomms11324
  • The obesity-induced transcriptional regulator TRIP-Br2 mediates visceral
           fat endoplasmic reticulum stress-induced inflammation

    • Abstract: Visceral and subcutaneous fat are associated with different metabolic risk, but mediators of such depot specific effects are not very well known. Here the authors identify the transcriptional regulator, TRIP-Br2, as a regulator of endoplasmic reticulum (ER) stress-induced inflammatory responses specifically in visceral fat.
      Citation: Nature Communications
      PubDate: 2016-04-25|2016-04-25
      DOI: 10.1038/ncomms11378
  • Mechanical cell competition kills cells via induction of lethal p53 levels

    • Abstract: Cell competition is a quality control mechanism to eliminate unfit cells. Here the authors show that physical compaction of less fit cells surrounded by healthy neighbours leads to increased expression of tumour suppressor p53 in the compacted cells, causing cell death.
      Citation: Nature Communications
      PubDate: 2016-04-25|2016-04-25
      DOI: 10.1038/ncomms11373
  • Arabidopsis PROTEASOME REGULATOR1 is required for auxin-mediated
           suppression of proteasome activity and regulates auxin signalling

    • Authors: Bao-Jun Yang, Xin-Xin Han, Lin-Lin Yin, Mei-Qing Xing, Zhi-Hong Xu, Hong-Wei Xue
      Abstract: Plant responses to auxin require proteasome-mediated degradation of Aux/IAA transcriptional repressor proteins. Here, Yang et al . show that auxin suppresses proteasome activity in a manner dependent on the proteasome regulator PTRE1 and propose a mechanism for fine tuning Aux/IAA homoeostasis.
      Citation: Nature Communications
      PubDate: 2016-04-25|2016-04-25
      DOI: 10.1038/ncomms11388
  • Thiol reductive stress induces cellulose-anchored biofilm formation in
           Mycobacterium tuberculosis

    • Authors: Abhishek Trivedi, Parminder Singh Mavi, Deepak Bhatt, Ashwani Kumar
      Abstract: When grown in the lab, Mycobacterium tuberculosis can form pellicle biofilms. Here, Trivedi et al . show that thiol reductive stress (induced by dithiothreitol) triggers rapid formation of thicker biofilms containing cellulose as well as antibiotic-tolerant, metabolically active bacteria.
      Citation: Nature Communications
      PubDate: 2016-04-25|2016-04-25
      DOI: 10.1038/ncomms11392
  • Host gene constraints and genomic context impact the expression and
           evolution of human microRNAs

    • Abstract: Recent miRNAs tend to emerge within coding genes. Here, by analysing miRNA expression data from six species and comparing genomes from 13 species, the authors report that host genes may provide stronger expression constraints to intragenic miRNAs in the long run.
      Citation: Nature Communications
      PubDate: 2016-04-25|2016-04-25
      DOI: 10.1038/ncomms11438
  • Spontaneous formation and base pairing of plausible prebiotic nucleotides
           in water

    • Authors: Brian J. Cafferty, David M. Fialho, Jaheda Khanam, Ramanarayanan Krishnamurthy, Nicholas V. Hud
      Abstract: One of the questions for prebiotic chemistry is the formation of complementary base pairing systems. Here, the authors show that plausible two prebiotic heterocycles can form glycosidic bonds with ribose in water and that these spontaneously base-pair in aqueous solution.
      Citation: Nature Communications
      PubDate: 2016-04-25|2016-04-25
      DOI: 10.1038/ncomms11328
  • Single-cell RNA-seq reveals cell type-specific transcriptional signatures
           at the maternal–foetal interface during pregnancy

    • Authors: Andrew C. Nelson, Arne W. Mould, Elizabeth K. Bikoff, Elizabeth J. Robertson
      Abstract: The zinc finger transcriptional repressor Prdm1 /Blimp1 is essential for remodelling maternal blood vessels in a subset of trophoblast cells. Here, the authors perform single-cell RNA-seq analysis on this Blimp1+ lineage, identifying functionally distinct cell types present at the maternal–foetal interface.
      Citation: Nature Communications
      PubDate: 2016-04-25|2016-04-25
      DOI: 10.1038/ncomms11414
  • Enhanced nonlinear interactions in quantum optomechanics via mechanical

    • Authors: Marc-Antoine Lemonde, Nicolas Didier, Aashish A. Clerk
      Abstract: Optomechanics harnesses the interaction between mechanical resonators and light, but weak matter–single-photon interactions limit studies to the linear regime. Here, the authors show that the interaction can be enhanced by modulating the spring constant of the resonator.
      Citation: Nature Communications
      PubDate: 2016-04-25|2016-04-25
      DOI: 10.1038/ncomms11338
  • Foldamer-mediated manipulation of a pre-amyloid toxin

    • Authors: Sunil Kumar, Melissa Birol, Diana E. Schlamadinger, Slawomir P. Wojcik, Elizabeth Rhoades, Andrew D. Miranker
      Abstract: Intrinsically disordered proteins that form amyloid fibrils are hard to target with traditional therapeutic approaches. Here, the authors report on an oligoquinoline derivative that binds the human islet amyloid polypeptide, stabilising an alpha-helical structure that reduces its cellular toxicity.
      Citation: Nature Communications
      PubDate: 2016-04-25|2016-04-25
      DOI: 10.1038/ncomms11412
  • A genetic basis for the variation in the vulnerability of cancer to DNA

    • Authors: Brian D. Yard, Drew J. Adams, Eui Kyu Chie, Pablo Tamayo, Jessica S. Battaglia, Priyanka Gopal, Kevin Rogacki, Bradley E. Pearson, James Phillips, Daniel P. Raymond, Nathan A. Pennell, Francisco Almeida, Jaime H. Cheah, Paul A. Clemons, Alykhan Shamji, Craig D. Peacock, Stuart L. Schreiber, Peter S. Hammerman, Mohamed E. Abazeed
      Abstract: The variability in patient response to radiation treatment is difficult to predict. Here, using more than 500 cell lines the authors measure response to radiation exposure and a large panel of compounds, and show that response can be predicted by genetic alterations of the cells.
      Citation: Nature Communications
      PubDate: 2016-04-25|2016-04-25
      DOI: 10.1038/ncomms11428
  • Identifying genetically driven clinical phenotypes using linear mixed

    • Authors: Jonathan D. Mosley, John S. Witte, Emma K. Larkin, Lisa Bastarache, Christian M. Shaffer, Jason H. Karnes, C. Michael Stein, Elizabeth Phillips, Scott J. Hebbring, Murray H. Brilliant, John Mayer, Zhan Ye, Dan M. Roden, Joshua C. Denny
      Abstract: Use of general linear mixed models (GLMMs) in genetic variance analysis can quantify the relative contribution of additive effects from genetic variation on a given trait. Here, Jonathan Mosley and colleagues apply GLMM in a phenome-wide analysis and show that genetic variations in the HLA region are associated with 44 phenotypes, 5 phenotypes which were not previously reported in GWASes.
      Citation: Nature Communications
      PubDate: 2016-04-25|2016-04-25
      DOI: 10.1038/ncomms11433
  • Retroviral intasomes search for a target DNA by 1D diffusion which rarely
           results in integration

    • Authors: Nathan D. Jones, Miguel A. Lopez Jr, Jeungphill Hanne, Mitchell B. Peake, Jong-Bong Lee, Richard Fishel, Kristine E. Yoder
      Abstract: Retroviral Integration into the host DNA is a rare event with evidence suggesting that it relies on DNA topology and sequence. Here the authors present single molecule evidence that shows the retroviral integration machinery vigorously scans the target DNA by 1D-diffusion but infrequently integrates.
      Citation: Nature Communications
      PubDate: 2016-04-25|2016-04-25
      DOI: 10.1038/ncomms11409
  • A modular design of molecular qubits to implement universal quantum gates

    • Abstract: The physical implementation of quantum information processing requires individual qubits and entangling gates. Here, the authors demonstrate a modular implementation through chemistry, assembling molecular {Cr 7 Ni} rings acting as qubits, with supramolecular structures realizing gates by choice of the linker.
      Citation: Nature Communications
      PubDate: 2016-04-25|2016-04-25
      DOI: 10.1038/ncomms11377
  • Comparative analysis of ear-hole closure identifies epimorphic
           regeneration as a discrete trait in mammals

    • Authors: Thomas R. Gawriluk, Jennifer Simkin, Katherine L. Thompson, Shishir K. Biswas, Zak Clare-Salzler, John M. Kimani, Stephen G. Kiama, Jeramiah J. Smith, Vanessa O. Ezenwa, Ashley W. Seifert
      Abstract: The extent to which mammals and other vertebrates share similar mechanisms of tissue regeneration is unclear. Here, the authors use an ear punch assay in spiny mice, which regenerate fully, to show blastema formation and mesenchymal cell proliferation as cell cycle regulators p21 and p27 remain cytoplasmic.
      Citation: Nature Communications
      PubDate: 2016-04-25|2016-04-25
      DOI: 10.1038/ncomms11164
  • The HSP70 co-chaperone DNAJC14 targets misfolded pendrin for
           unconventional protein secretion

    • Authors: Jinsei Jung, Jiyoon Kim, Shin Hye Roh, Ikhyun Jun, Robert D. Sampson, Heon Yung Gee, Jae Young Choi, Min Goo Lee
      Abstract: Mutations in pendrin, a plasma membrane transporter, lead to Pendred syndrome, which is associated with hearing loss. Here, Jung et al . show that cell-surface expression of a mutated form of pendrin can be restored by blocking ER-to-Golgi traffic and triggering a DNAJC14 dependent unconventional secretion pathway.
      Citation: Nature Communications
      PubDate: 2016-04-25|2016-04-25
      DOI: 10.1038/ncomms11386
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