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  Subjects -> PHYSICS (Total: 800 journals)
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PHYSICS (576 journals)

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Journal Cover Nature Communications
  [SJR: 6.539]   [H-I: 114]   [206 followers]  Follow
    
  This is an Open Access Journal Open Access journal
   ISSN (Online) 2041-1723
   Published by NPG Homepage  [135 journals]
  • The Chemical Fluctuation Theorem governing gene expression
    • The Chemical Fluctuation Theorem governing gene expression

      The Chemical Fluctuation Theorem governing gene expression, Published online: 19 January 2018; doi:10.1038/s41467-017-02737-0

      A unified framework to understand gene expression noise is still lacking. Here the authors derive a universal theorem relating the biological noise with dynamics of birth and death processes and present a model of transcription dynamics, allowing analytical prediction of the dependence of mRNA noise on mRNA lifetime variability.The Chemical Fluctuation Theorem governing gene expression, Published online: 2018-01-19; doi:10.1038/s41467-017-02737-02018-01-19
      DOI: 10.1038/s41467-017-02737-0
       
  • Direct cell–cell contact between mature osteoblasts and osteoclasts
           dynamically controls their functions in vivo
    • Direct cell–cell contact between mature osteoblasts and osteoclasts dynamically controls their functions in vivo

      Direct cell–cell contact between mature osteoblasts and osteoclasts dynamically controls their functions in vivo, Published online: 19 January 2018; doi:10.1038/s41467-017-02541-w

      Communication between osteoblasts and osteoclasts is essential for bone homeostasis, but the mode of interaction is unclear. The authors use intravital two-photon microscopy in mice to show that these cells directly interact, regulating activity of osteoclasts, and that the interaction is modulated by parathyroid hormone administration.Direct cell–cell contact between mature osteoblasts and osteoclasts dynamically controls their functions in vivo, Published online: 2018-01-19; doi:10.1038/s41467-017-02541-w2018-01-19
      DOI: 10.1038/s41467-017-02541-w
       
  • Binding of NUFIP2 to Roquin promotes recognition and regulation of
           ICOS mRNA
    • Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA

      Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA, Published online: 19 January 2018; doi:10.1038/s41467-017-02582-1

      The RNA-binding proteins Roquin-1 and Roquin-2 are essential for immune cell function and postnatal survival in mice. Here, the authors identify NUFIP2 as a cofactor of Roquin; Roquin binds and stabilizes NUFIP2 in cells while NUFIP2 regulates Roquin mRNA target recognition.Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA, Published online: 2018-01-19; doi:10.1038/s41467-017-02582-12018-01-19
      DOI: 10.1038/s41467-017-02582-1
       
  • PTRE-seq reveals mechanism and interactions of RNA binding proteins and
           miRNAs
    • PTRE-seq reveals mechanism and interactions of RNA binding proteins and miRNAs

      PTRE-seq reveals mechanism and interactions of RNA binding proteins and miRNAs, Published online: 19 January 2018; doi:10.1038/s41467-017-02745-0

      A large number of RNA binding proteins (RBPs) and miRNAs bind to the 3′ untranslated regions of mRNA, but methods to dissect their function and interactions are lacking. Here the authors introduce post-transcriptional regulatory element sequencing (PTRE-seq) to dissect sequence preferences, interactions and consequences of RBP and miRNA binding.PTRE-seq reveals mechanism and interactions of RNA binding proteins and miRNAs, Published online: 2018-01-19; doi:10.1038/s41467-017-02745-02018-01-19
      DOI: 10.1038/s41467-017-02745-0
       
  • Author Correction: Long-term carbon sink in Borneo’s forests halted by
           drought and vulnerable to edges
    • Author Correction: Long-term carbon sink in Borneo’s forests halted by drought and vulnerable to edges

      Author Correction: Long-term carbon sink in Borneo’s forests halted by drought and vulnerable to edges, Published online: 19 January 2018; doi:10.1038/s41467-018-02920-x

      Author Correction: Long-term carbon sink in Borneo’s forests halted by drought and vulnerable to edgesAuthor Correction: Long-term carbon sink in Borneo’s forests halted by drought and vulnerable to edges, Published online: 2018-01-19; doi:10.1038/s41467-018-02920-x2018-01-19
      DOI: 10.1038/s41467-018-02920-x
       
  • Environmental enrichment increases transcriptional and epigenetic
           differentiation between mouse dorsal and ventral dentate gyrus
    • Environmental enrichment increases transcriptional and epigenetic differentiation between mouse dorsal and ventral dentate gyrus

      Environmental enrichment increases transcriptional and epigenetic differentiation between mouse dorsal and ventral dentate gyrus, Published online: 19 January 2018; doi:10.1038/s41467-017-02748-x

      Environmental enrichment has functional and molecular effects on mammalian hippocampus. Here, Zhang and colleagues show that environmental enrichment of mice is correlated with dorsal-ventral asymmetry in transcription and DNA methylation of the dentate gyrus.Environmental enrichment increases transcriptional and epigenetic differentiation between mouse dorsal and ventral dentate gyrus, Published online: 2018-01-19; doi:10.1038/s41467-017-02748-x2018-01-19
      DOI: 10.1038/s41467-017-02748-x
       
  • BLM helicase suppresses recombination at G-quadruplex motifs in
           transcribed genes
    • BLM helicase suppresses recombination at G-quadruplex motifs in transcribed genes

      BLM helicase suppresses recombination at G-quadruplex motifs in transcribed genes, Published online: 18 January 2018; doi:10.1038/s41467-017-02760-1

      Bloom syndrome is characterized by high levels of sister chromatid exchanges (SCEs). Here, the authors use single-cell DNA template strand-sequencing to map SCEs in patient cells, and propose that the BLM helicase protects the genome against unwanted recombination at sites of G-quadruplex structures.BLM helicase suppresses recombination at G-quadruplex motifs in transcribed genes, Published online: 2018-01-18; doi:10.1038/s41467-017-02760-12018-01-18
      DOI: 10.1038/s41467-017-02760-1
       
  • A biosensor-based framework to measure latent proteostasis capacity
    • A biosensor-based framework to measure latent proteostasis capacity

      A biosensor-based framework to measure latent proteostasis capacity, Published online: 18 January 2018; doi:10.1038/s41467-017-02562-5

      A pool of quality control proteins (QC) maintains the protein-folding homeostasis in the cell, but its quantitative analysis is challenging. Here the authors develop a FRET sensor based on the protein barnase, able to quantify QC holdase activity and its ability to suppress protein aggregation.A biosensor-based framework to measure latent proteostasis capacity, Published online: 2018-01-18; doi:10.1038/s41467-017-02562-52018-01-18
      DOI: 10.1038/s41467-017-02562-5
       
 
 
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