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Nature Communications

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Partially Free or Hybrid journal

Partially Free Journal
ISSN (Online) 2041-1723
Published by Nature Publishing Group

[134 journals]

Whole-community DNA barcoding reveals a spatio-temporal continuum of biodiversity at species and genetic levels
- Authors: Andrés Baselga|Tomochika Fujisawa|Alexandra Crampton-Platt|Johannes Bergsten|Peter G. Foster|Michael T. Monaghan|Alfried P. Vogler
  Abstract: A correlation between species and genetic diversity has been suggested. Here Baselga et al. provide evidence of a concordant decrease in beetle community similarity at species and genetic levels with geographic distance, suggesting a macroecological pattern which may follow neutral evolutionary processes.
  Citation: Nature Communications 4, 1892 (2013)
  PubDate: 2013-05-21
  DOI: 10.1038/ncomms2881
  Issue No: Vol. 4 (2013)
A new Late Triasssic phytogeographical scenario in westernmost Gondwana
- Authors: Silvia N Césari|Carina E Colombi
  Abstract: In the Late Triassic, southern Gondwanan flora is thought to have been dominated by endemic species mainly restricted to eastern areas with some mixing with northern species. In this study, pollen and spore assemblages from Argentina reveal the presence of these mixed flora in the westernmost Gondwana as well.
  Citation: Nature Communications 4, 1889 (2013)
  PubDate: 2013-05-21
  DOI: 10.1038/ncomms2917
  Issue No: Vol. 4 (2013)
Aurora-A controls pre-replicative complex assembly and DNA replication by stabilizing geminin in mitosis
- Authors: Takaaki Tsunematsu|Yoshihiro Takihara|Naozumi Ishimaru|Michele Pagano|Takashi Takata|Yasusei Kudo
  Abstract: Geminin blocks the inappropriate assembly of pre-replication complexes on DNA, and this activity is inhibited in G1 by its proteasomal degradation. Tsunematsu et al. demonstrate that geminin is stabilized during mitosis due to its phosphorylation by the mitotic kinase Aurora-A.
  Citation: Nature Communications 4, 1885 (2013)
  PubDate: 2013-05-21
  DOI: 10.1038/ncomms2859
  Issue No: Vol. 4 (2013)
Dehydrated hereditary stomatocytosis linked to gain-of-function mutations in mechanically activated PIEZO1 ion channels
- Authors: Juliette Albuisson|Swetha E Murthy|Michael Bandell|Bertrand Coste|Hélène Louis-dit-Picard|Jayanti Mathur|Madeleine Fénéant-Thibault|Gérard Tertian|Jean-Pierre de Jaureguiberry|Pierre-Yves Syfuss|Stuart Cahalan|Loic Garçon|Fabienne Toutain|Pierre Simon Rohrlich|Jean Delaunay|Véronique Picard|Xavier Jeunemaitre|Ardem Patapoutian
  Abstract: Dehydrated hereditary stomatocytosis is a genetic condition in which the permeability of red blood cells to cations in increased. Albuisson and colleagues find that mutations in the mechanically-activated PIEZO1 ion channel are the major cause of the disease and result in more slowly inactivating currents.
  Citation: Nature Communications 4, 1884 (2013)
  PubDate: 2013-05-21
  DOI: 10.1038/ncomms2899
  Issue No: Vol. 4 (2013)
PI 3-kinase-dependent phosphorylation of Plk1–Ser99 promotes association with 14-3-3γ and is required for metaphase–anaphase transition
- Authors: Kousuke Kasahara|Hidemasa Goto|Ichiro Izawa|Tohru Kiyono|Nobumoto Watanabe|Sabine Elowe|Erich A Nigg|Masaki Inagaki
  Abstract: Polo-like kinase 1 (Plk1) controls the transition between metaphase and anaphase during mitosis. Kasahara et al. show that Plk1 activity is regulated by phosphatidylinositide 3-kinase signalling through phosphorylation at a previously uncharacterized site.
  Citation: Nature Communications 4, 1882 (2013)
  PubDate: 2013-05-21
  DOI: 10.1038/ncomms2879
  Issue No: Vol. 4 (2013)
Mycobacterium tuberculosis is extraordinarily sensitive to killing by a vitamin C-induced Fenton reaction
- Authors: Catherine Vilchèze|Travis Hartman|Brian Weinrick|William R. Jacobs
  Abstract: New approaches to kill Mycobacterium tuberculosis are required to improve TB therapy. Vilchèze et al. now demonstrate that vitamin C-derived reactive oxygen species lead to sterilization of drug-susceptible and drug-resistant M. tuberculosis offering new possibilities for drug development.
  Citation: Nature Communications 4, 1881 (2013)
  PubDate: 2013-05-21
  DOI: 10.1038/ncomms2898
  Issue No: Vol. 4 (2013)
Dll1 maintains quiescence of adult neural stem cells and segregates asymmetrically during mitosis
- Authors: Daichi Kawaguchi|Shohei Furutachi|Hiroki Kawai|Katsuto Hozumi|Yukiko Gotoh
  Abstract: Neural stem cells in the adult brain maintain their pool size while producing new neurons. Kawaguchi et al. show that, during neural stem cell mitosis in the adult mouse subventricular zone, the Notch ligand Dll1 is asymmetrically segregated to one daughter cell, which undergoes differentiation.
  Citation: Nature Communications 4, 1880 (2013)
  PubDate: 2013-05-21
  DOI: 10.1038/ncomms2895
  Issue No: Vol. 4 (2013)
Advanced zinc-air batteries based on high-performance hybrid electrocatalysts
- Authors: Yanguang Li|Ming Gong|Yongye Liang|Ju Feng|Ji-Eun Kim|Hailiang Wang|Guosong Hong|Bo Zhang|Hongjie Dai
  First page: 1805
  Abstract: Metal-air batteries are promising for energy storage because of their high theoretical energy density, but their realization is hampered by the lack of efficient and robust air catalysts. Li et al. construct stable zinc-air batteries using novel catalysts for oxygen reduction and evolution reactions.
  Citation: Nature Communications 4, 1805 (2013)
  PubDate: 2013-05-07
  DOI: 10.1038/ncomms2812
  Issue No: Vol. 4 (2013)
Gene network reconstruction reveals cell cycle and antiviral genes as major drivers of cervical cancer
- Authors: Karina L. Mine|Natalia Shulzhenko|Anatoly Yambartsev|Mark Rochman|Gerdine F. O. Sanson|Malin Lando|Sudhir Varma|Jeff Skinner|Natalia Volfovsky|Tao Deng|Sylvia M. F. Brenna|Carmen R. N. Carvalho|Julisa C. L. Ribalta|Michael Bustin|Polly Matzinger|Ismael D. C. G. Silva|Heidi Lyng|Maria Gerbase-DeLima|Andrey Morgun
  First page: 1806
  Abstract: As cervical tumours become more invasive, levels of episomal human papillomavirus paradoxically tend to decrease. Here the authors identify a network of antiviral and cell cycle genes that is amplified by chromosomal aberrations and promotes cervical tumour progression.
  Citation: Nature Communications 4, 1806 (2013)
  PubDate: 2013-05-07
  DOI: 10.1038/ncomms2693
  Issue No: Vol. 4 (2013)
Establishment of a robust single axis of cell polarity by coupling multiple positive feedback loops
- Authors: Tina Freisinger|Ben Klünder|Jared Johnson|Nikola Müller|Garwin Pichler|Gisela Beck|Michael Costanzo|Charles Boone|Richard A. Cerione|Erwin Frey|Roland Wedlich-Söldner
  First page: 1807
  Abstract: A positive feedback loop which results in localized accumulation of the small GTPase Cdc42 generates cell polarity in budding yeast; however, such loops are inherently susceptible to noise. Here the authors demonstrate how two pathways that mediate Cdc42 recycling work together to ensure the robustness of symmetry breaking.
  Citation: Nature Communications 4, 1807 (2013)
  PubDate: 2013-05-07
  DOI: 10.1038/ncomms2795
  Issue No: Vol. 4 (2013)
Free-electron gas at charged domain walls in insulating BaTiO3
- Authors: Tomas Sluka|Alexander K. Tagantsev|Petr Bednyakov|Nava Setter
  First page: 1808
  Abstract: Although ferroelectrics are generally insulating, their domain walls can show electrical conductivity. Here Sluka et al. observe a highly conducting free-electron gas at charged domain walls in ferroelectric BaTiO3.
  Citation: Nature Communications 4, 1808 (2013)
  PubDate: 2013-05-07
  DOI: 10.1038/ncomms2839
  Issue No: Vol. 4 (2013)
Interspecific bacterial sensing through airborne signals modulates locomotion and drug resistance
- Authors: Kwang-sun Kim|Soohyun Lee|Choong-Min Ryu
  First page: 1809
  Abstract: Microbes use small molecules to sense and communicate with other cells and species. Kim et al. now demonstrate that volatile compounds emitted by Bacillus subtilis can affect Escherichia coli motility and antibiotic resistance through activation of a conserved regulatory mechanism.
  Citation: Nature Communications 4, 1809 (2013)
  PubDate: 2013-05-07
  DOI: 10.1038/ncomms2789
  Issue No: Vol. 4 (2013)
Characterization of salt-adapted secreted lignocellulolytic enzymes from the mangrove fungus Pestalotiopsis sp.
- Authors: Yonathan Arfi|Didier Chevret|Bernard Henrissat|Jean-Guy Berrin|Anthony Levasseur|Eric Record
  First page: 1810
  Abstract: Fungi associated with the roots of mangroves are thought to turn-over significant quantities of organic matter including lignocellulose. Arfi et al. investigate the lignocellolytic potential of a fungal species isolated from mangrove roots and the adaptation of its enzymatic repertoire to a high salinity environment.
  Citation: Nature Communications 4, 1810 (2013)
  PubDate: 2013-05-07
  DOI: 10.1038/ncomms2850
  Issue No: Vol. 4 (2013)
Broadband high photoresponse from pure monolayer graphene photodetector
- Authors: By Yongzhe Zhang|Tao Liu|Bo Meng|Xiaohui Li|Guozhen Liang|Xiaonan Hu|Qi Jie Wang
  First page: 1811
  Abstract: Graphene holds great potential for use in photodetectors, owing to its ability to absorb light over a wide range of wavelengths. Here Zhang et al. report a large photoresponsivity of 8.6 AW-1 over a broad wavelength range in pure monolayer graphene.
  Citation: Nature Communications 4, 1811 (2013)
  PubDate: 2013-05-07
  DOI: 10.1038/ncomms2830
  Issue No: Vol. 4 (2013)
Transmission-blocking interventions eliminate malaria from laboratory populations
- Authors: A. M. Blagborough|T. S. Churcher|L. M. Upton|A. C. Ghani|P. W. Gething|R. E. Sinden
  First page: 1812
  Abstract: Transmission-blocking interventions aim to interrupt progression of Plasmodium parasites from the vertebrate host to the mosquito. Blagborough et al. demonstrate that only partially reducing transmission can be sufficient to eliminate experimental Plasmodium infection in successive mosquito and mice populations when biting rates are low.
  Citation: Nature Communications 4, 1812 (2013)
  PubDate: 2013-05-07
  DOI: 10.1038/ncomms2840
  Issue No: Vol. 4 (2013)
An isoform of retinoid-related orphan receptor β directs differentiation of retinal amacrine and horizontal interneurons
- Authors: Hong Liu|Soo-Young Kim|Yulong Fu|Xuefeng Wu|Lily Ng|Anand Swaroop|Douglas Forrest
  First page: 1813
  Abstract: Amacrine interneurons act as integrators of visual information in the retina; however the developmental mechanisms that determine this cell fate remain unclear. Liu et al. find that amacrine differentiation in the retina is driven by the transcription factor RORβ1.
  Citation: Nature Communications 4, 1813 (2013)
  PubDate: 2013-05-07
  DOI: 10.1038/ncomms2793
  Issue No: Vol. 4 (2013)
A sex-specific transcription factor controls male identity in a simultaneous hermaphrodite
- Authors: Tracy Chong|James J. Collins|John L. Brubacher|David Zarkower|Phillip A. Newmark
  First page: 1814
  Abstract: Hermaphrodites develop and maintain male and female reproductive organs in a single individual. Chong et al. show that a DM domain transcription factor is required for male germ cell regeneration and maintains ‘maleness’ in a hermaphrodite, the planarian flatworm Schmidtea mediterranea.
  Citation: Nature Communications 4, 1814 (2013)
  PubDate: 2013-05-07
  DOI: 10.1038/ncomms2811
  Issue No: Vol. 4 (2013)
Relation between the nodal and antinodal gap and critical temperature in superconducting Bi2212
- Authors: H. Anzai|A. Ino|M. Arita|H. Namatame|M. Taniguchi|M. Ishikado|K. Fujita|S. Ishida|S. Uchida
  First page: 1815
  Abstract: In conventional superconductors, the critical temperature is proportional to the superconducting energy gap, but this is not so in unconventional superconductors. Anzai et al. identify an alternative relationship involving nodal and antinodal gaps in an underdoped cuprate superconductor.
  Citation: Nature Communications 4, 1815 (2013)
  PubDate: 2013-05-07
  DOI: 10.1038/ncomms2805
  Issue No: Vol. 4 (2013)
A functional deficiency of TERA/VCP/p97 contributes to impaired DNA repair in multiple polyglutamine diseases
- Authors: Kyota Fujita|Yoko Nakamura|Tsutomu Oka|Hikaru Ito|Takuya Tamura|Kazuhiko Tagawa|Toshikazu Sasabe|Asuka Katsuta|Kazumi Motoki|Hiroki Shiwaku|Masaki Sone|Chisato Yoshida|Masahisa Katsuno|Yoshinobu Eishi|Miho Murata|J. Paul Taylor|Erich E. Wanker|Kazuteru Kono|Satoshi Tashiro|Gen Sobue|Albert R. La Spada|Hitoshi Okazawa
  First page: 1816
  Abstract: Mutations in polyglutamine proteins are implicated in neurodegenerative disorders. Okazawa and colleagues now demonstrate that mutant polyQ proteins interact directly with the ATPase TERA, resulting in reduced DNA double-strand break repair, which is a feature of neurodegenerative diseases.
  Citation: Nature Communications 4, 1816 (2013)
  PubDate: 2013-05-07
  DOI: 10.1038/ncomms2828
  Issue No: Vol. 4 (2013)
A reversible long-life lithium–air battery in ambient air
- Authors: Tao Zhang|Haoshen Zhou
  First page: 1817
  Abstract: Lithium air batteries have among the highest energy storage capacities, but their effective lifetime is short when using liquid electrolytes. Zhang et al. realize a lithium air battery with much improved cycling stability in ambient air by combining a solid electrolyte and a gel cathode.
  Citation: Nature Communications 4, 1817 (2013)
  PubDate: 2013-05-07
  DOI: 10.1038/ncomms2855
  Issue No: Vol. 4 (2013)
A versatile source of single photons for quantum information processing
- Authors: Michael Förtsch|Josef U. Fürst|Christoffer Wittmann|Dmitry Strekalov|Andrea Aiello|Maria V. Chekhova|Christine Silberhorn|Gerd Leuchs|Christoph Marquardt
  First page: 1818
  Abstract: High-quality narrow bandwidth single-photon states with tunable frequency are essential for quantum and atomic technologies. Using a whispering gallery mode resonator, Förtsch et al. build such a source with wavelength tuning across 100 nm and controllable narrow bandwidth.
  Citation: Nature Communications 4, 1818 (2013)
  PubDate: 2013-05-07
  DOI: 10.1038/ncomms2838
  Issue No: Vol. 4 (2013)
Polytype control of spin qubits in silicon carbide
- Authors: Abram L. Falk|Bob B. Buckley|Greg Calusine|William F. Koehl|Viatcheslav V. Dobrovitski|Alberto Politi|Christian A. Zorman|Philip X.-L. Feng|David D. Awschalom
  First page: 1819
  Abstract: Silicon carbide is a polymorphic material with over 250 known crystal structures. Here the authors show that such polymorphism can be used as a degree of freedom for engineering optically addressable and coherently interacting spin states, including many with room-temperature quantum coherence.
  Citation: Nature Communications 4, 1819 (2013)
  PubDate: 2013-05-07
  DOI: 10.1038/ncomms2854
  Issue No: Vol. 4 (2013)
Regulation of adipose oestrogen output by mechanical stress
- Authors: Sagar Ghosh|Keith Ashcraft|Md Jamiul Jahid|Craig April|Cyrus M. Ghajar|Jianhua Ruan|Howard Wang|Megan Foster|Daniel C. Hughes|Amelie G. Ramirez|Tim Huang|Jian-Bing Fan|Yanfen Hu|Rong Li
  First page: 1821
  Abstract: Aberrant production of oestrogens by adipose stromal cells is a driving factor in oestrogen receptor-positive breast cancer. Here the authors discover that oestrogen synthesis in adipose tissue is regulated by mechanical stress, and reveal how this effect is mediated.
  Citation: Nature Communications 4, 1821 (2013)
  PubDate: 2013-05-07
  DOI: 10.1038/ncomms2794
  Issue No: Vol. 4 (2013)
Proteolysis of MOB1 by the ubiquitin ligase praja2 attenuates Hippo signalling and supports glioblastoma growth
- Authors: Luca Lignitto|Antonietta Arcella|Maria Sepe|Laura Rinaldi|Rossella Delle Donne|Adriana Gallo|Eduard Stefan|Verena A. Bachmann|Maria A. Oliva|Clelia Tiziana Storlazzi|Alberto L'Abbate|Arturo Brunetti|Sara Gargiulo|Matteo Gramanzini|Luigi Insabato|Corrado Garbi|Max E. Gottesman|Antonio Feliciello
  First page: 1822
  Abstract: Tumour suppressors can be inactivated in cancer not only as a result of mutation, but also by proteolytic degradation. Here the authors show that, during glioma development, the accumulation of the ubiquitin ligase praja2 sustains tumour growth by degrading MOB1—a core component of the Hippo pathway.
  Citation: Nature Communications 4, 1822 (2013)
  PubDate: 2013-05-07
  DOI: 10.1038/ncomms2791
  Issue No: Vol. 4 (2013)
A universal description of ultraslow glass dynamics
- Authors: Julio Cesar Martinez-Garcia|Sylwester J. Rzoska|Aleksandra Drozd-Rzoska|Jorge Martinez-Garcia
  First page: 1823
  Abstract: The Vogel–Fulcher–Tamman equation is widely used to describe glass dynamics, but its validity below glass-transition temperature is still in debate. Martinez-Garcia et al. propose a critical-like parameterization to connect dynamics and local symmetry, which works for a broad range of glass formers.
  Citation: Nature Communications 4, 1823 (2013)
  PubDate: 2013-05-07
  DOI: 10.1038/ncomms2797
  Issue No: Vol. 4 (2013)
SMRT compounds abrogate cellular phenotypes of ataxia telangiectasia in neural derivatives of patient-specific hiPSCs
- Authors: Peiyee Lee|Nathan T. Martin|Kotoka Nakamura|Soheila Azghadi|Mandana Amiri|Uri Ben-David|Susan Perlman|Richard A. Gatti|Hailiang Hu|William E. Lowry
  First page: 1824
  Abstract: Ataxia telangiectasia is a genetic disease that results in various pathological disorders. In this study, the authors develop an in vitro model of Ataxia telangiectasia using human induced pluripotent stem cells, and find that physiological defects can be alleviated by small molecule read-through compounds.
  Citation: Nature Communications 4, 1824 (2013)
  PubDate: 2013-05-07
  DOI: 10.1038/ncomms2824
  Issue No: Vol. 4 (2013)
Select interneuron clusters determine female sexual receptivity in Drosophila
- Authors: Akira Sakurai|Masayuki Koganezawa|Kei-ichiro Yasunaga|Kazuo Emoto|Daisuke Yamamoto
  First page: 1825
  Abstract: The protein spinster is implicated in Drosophila courtship behaviour. Sakurai and colleagues identify two clusters of spinster-expressing interneurons, and show that these cells are required for female receptivity to male advances.
  Citation: Nature Communications 4, 1825 (2013)
  PubDate: 2013-05-07
  DOI: 10.1038/ncomms2837
  Issue No: Vol. 4 (2013)
Engineering fluid flow using sequenced microstructures
- Authors: Hamed Amini|Elodie Sollier|Mahdokht Masaeli|Yu Xie|Baskar Ganapathysubramanian|Howard A. Stone|Dino Di Carlo
  First page: 1826
  Abstract: A versatile strategy is needed to engineer fluid streams in channels for different purposes. Amini et al. develop an approach to decompose complicated fluid motion into an ensemble of fluid transformations around individual cylindrical pillars, which allows control without simulations.
  Citation: Nature Communications 4, 1826 (2013)
  PubDate: 2013-05-07
  DOI: 10.1038/ncomms2841
  Issue No: Vol. 4 (2013)
Genomic islands of divergence are not affected by geography of speciation in sunflowers
- Authors: S. Renaut|C. J. Grassa|S. Yeaman|B. T. Moyers|Z. Lai|N. C. Kane|J. E. Bowers|J. M. Burke|L. H. Rieseberg
  First page: 1827
  Abstract: Differentiated genomic regions among conserved loci, known as speciation islands, are believed to form because of reduced inter-population gene flow near loci under divergent selection. Renault et al. show that reduced recombination, rather than slower gene flow, accounts for the formation of these regions in sunflowers.
  Citation: Nature Communications 4, 1827 (2013)
  PubDate: 2013-05-07
  DOI: 10.1038/ncomms2833
  Issue No: Vol. 4 (2013)
The oldest North American pachycephalosaurid and the hidden diversity of small-bodied ornithischian dinosaurs
- Authors: David C. Evans|Ryan K. Schott|Derek W. Larson|Caleb M. Brown|Michael J. Ryan
  First page: 1828
  Abstract: Fossils of small dinosaurs are less common than their large-bodied counterparts, but whether this relates to preservational biases remains unclear. Evans et al. describe a new pachycephalosaur and provide the first evidence that small-bodied dinosaur diversity is strongly underestimated.
  Citation: Nature Communications 4, 1828 (2013)
  PubDate: 2013-05-07
  DOI: 10.1038/ncomms2749
  Issue No: Vol. 4 (2013)
The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43
- Authors: Ikuo Kimura|Kentaro Ozawa|Daisuke Inoue|Takeshi Imamura|Kumi Kimura|Takeshi Maeda|Kazuya Terasawa|Daiji Kashihara|Kanako Hirano|Taeko Tani|Tomoyuki Takahashi|Satoshi Miyauchi|Go Shioi|Hiroshi Inoue|Gozoh Tsujimoto
  First page: 1829
  Abstract: The gut microbiota produces metabolites such as short-chain fatty acids (SCFAs), which can influence the development of obesity. Here Kimura et al. show that SCFAs act via the receptor GPR43, which acts as a sensor for excessive dietary energy and controls body energy utilization as well as metabolic homoeostasis.
  Citation: Nature Communications 4, 1829 (2013)
  PubDate: 2013-05-07
  DOI: 10.1038/ncomms2852
  Issue No: Vol. 4 (2013)
GANP regulates recruitment of AID to immunoglobulin variable regions by modulating transcription and nucleosome occupancy
- Authors: Shailendra Kumar Singh|Kazuhiko Maeda|Mohammed Mansour Abbas Eid|Sarah Ameen Almofty|Masaya Ono|Phuong Pham|Myron F. Goodman|Nobuo Sakaguchi
  First page: 1830
  Abstract: The affinity of antibodies for their targets is enhanced by somatic hypermutation, in which the cytidine deaminase AID is recruited to immunoglobulin variable region genes in B cells. Here the authors show that the nuclear protein GANP has an important role in this process by modifying chromatin structure and enhancing AID recruitment.
  Citation: Nature Communications 4, 1830 (2013)
  PubDate: 2013-05-07
  DOI: 10.1038/ncomms2823
  Issue No: Vol. 4 (2013)
Deletion of cavin genes reveals tissue-specific mechanisms for morphogenesis of endothelial caveolae
- Authors: Carsten Gram Hansen|Elena Shvets|Gillian Howard|Kirsi Riento|Benjamin James Nichols
  First page: 1831
  Abstract: Cavin proteins are key components of mammalian caveolae and are expressed from four genes in a tissue-specific manner. Gram Hansen et al. demonstrate that caveolae in the endothelia of different tissues are remarkably heterogeneous, and reveal a role for cavin 2 in determining the apparent size of cavin complexes.
  Citation: Nature Communications 4, 1831 (2013)
  PubDate: 2013-05-07
  DOI: 10.1038/ncomms2808
  Issue No: Vol. 4 (2013)
ALKBH4-dependent demethylation of actin regulates actomyosin dynamics
- Authors: Ming-Ming Li|Anja Nilsen|Yue Shi|Markus Fusser|Yue-He Ding|Ye Fu|Bo Liu|Yamei Niu|Yong-Sheng Wu|Chun-Min Huang|Maria Olofsson|Kang-Xuan Jin|Ying Lv|Xing-Zhi Xu|Chuan He|Meng-Qiu Dong|Jannie M. Rendtlew Danielsen|Arne Klungland|Yun-Gui Yang
  First page: 1832
  Abstract: The division of a single eukaryotic cell into two requires actomyosin-dependent contraction. Here the authors show that lysine methylation of actin inhibits contractility during cytokinesis by blocking its association with myosin, and this modification is reversed at the contractile ring by the demethylase ALKBH4.
  Citation: Nature Communications 4, 1832 (2013)
  PubDate: 2013-05-14
  DOI: 10.1038/ncomms2863
  Issue No: Vol. 4 (2013)
Toll-like receptor 3 recognizes incomplete stem structures in single-stranded viral RNA
- Authors: Megumi Tatematsu|Fumiko Nishikawa|Tsukasa Seya|Misako Matsumoto
  First page: 1833
  Abstract: Toll-like receptor 3 is a sensor of viral infection and sterile tissue necrosis, and is known to be activated by double-stranded RNA. Tatematsu et al. demonstrate that TLR3 also recognizes incomplete stem structures that form in single-stranded poliovirus RNA.
  Citation: Nature Communications 4, 1833 (2013)
  PubDate: 2013-05-14
  DOI: 10.1038/ncomms2857
  Issue No: Vol. 4 (2013)
Spatial segregation of polarity factors into distinct cortical clusters is required for cell polarity control
- Authors: James Dodgson|Anatole Chessel|Miki Yamamoto|Federico Vaggi|Susan Cox|Edward Rosten|David Albrecht|Marco Geymonat|Attila Csikasz-Nagy|Masamitsu Sato|Rafael E. Carazo-Salas
  First page: 1834
  Abstract: Cell polarity is generated and maintained by the spatial accumulation of polarity factors. By imaging fission yeast cells ‘end-on’, the authors show that the polarity factors Tea1 and Tea3 segregate into distinct clusters, and that surprisingly, their segregation is critical for cell polarization.
  Citation: Nature Communications 4, 1834 (2013)
  PubDate: 2013-05-14
  DOI: 10.1038/ncomms2813
  Issue No: Vol. 4 (2013)
Measurement of the first ionization potential of astatine by laser ionization spectroscopy
- Authors: S. Rothe|A. N. Andreyev|S. Antalic|A. Borschevsky|L. Capponi|T. E. Cocolios|H. De Witte|E. Eliav|D. V. Fedorov|V. N. Fedosseev|D. A. Fink|S. Fritzsche|L. Ghys|M. Huyse|N. Imai|U. Kaldor|Yuri Kudryavtsev|U. Köster|J. F. W. Lane|J. Lassen|V. Liberati|K. M. Lynch|B. A. Marsh|K. Nishio|D. Pauwels|V. Pershina|L. Popescu|T. J. Procter|D. Radulov|S. Raeder|M. M. Rajabali|E. Rapisarda|R. E. Rossel|K. Sandhu|M. D. Seliverstov|A. M. Sjödin|P. Van den Bergh|P. Van Duppen|M. Venhart|Y. Wakabayashi|K. D. A. Wendt
  First page: 1835
  Abstract: The application of astatine, one of the rarest elements on the earth, in the treatment of cancer requires a better understanding of its chemistry. Rothe et al. report the first measurement of the ionization potential of astatine, against which high-level quantum calculations are benchmarked.
  Citation: Nature Communications 4, 1835 (2013)
  PubDate: 2013-05-14
  DOI: 10.1038/ncomms2819
  Issue No: Vol. 4 (2013)
PAD4 regulates proliferation of multipotent haematopoietic cells by controlling c-myc expression
- Authors: Katsuhiko Nakashima|Satoko Arai|Akari Suzuki|Yuko Nariai|Takeshi Urano|Manabu Nakayama|Osamu Ohara|Ken-ichi Yamamura|Kazuhiko Yamamoto|Toru Miyazaki
  First page: 1836
  Abstract: Histone citrullination by peptidylarginine deiminase 4 (PAD4) regulates transcription but its physiological role is unclear. Here Nakashima et al. show that PAD4 controls proliferation of multipotent haematopoietic cells by modulating c-myc expression.
  Citation: Nature Communications 4, 1836 (2013)
  PubDate: 2013-05-14
  DOI: 10.1038/ncomms2862
  Issue No: Vol. 4 (2013)
Calfacilitin is a calcium channel modulator essential for initiation of neural plate development
- Authors: Costis Papanayotou|Irene De Almeida|Ping Liao|Nidia M. M. Oliveira|Song-Qing Lu|Eleni Kougioumtzidou|Lei Zhu|Alex Shaw|Guojun Sheng|Andrea Streit|Dejie Yu|Tuck Wah Soong|Claudio D. Stern
  First page: 1837
  Abstract: Calcium signalling has been implicated in neural induction in the embryo. The authors identify Calfacilitin as a regulator of CaV1.2 calcium channels, which is required for induction of the pre-neural specifiers Geminin and Sox2 in the early chick embryo.
  Citation: Nature Communications 4, 1837 (2013)
  PubDate: 2013-05-14
  DOI: 10.1038/ncomms2864
  Issue No: Vol. 4 (2013)
Anisotropic two-dimensional electron gas at the LaAlO3/SrTiO3 (110) interface
- Authors: A. Annadi|Q. Zhang|X. Renshaw Wang|N. Tuzla|K. Gopinadhan|W. M. Lü|A. Roy Barman|Z. Q. Liu|A. Srivastava|S. Saha|Y. L. Zhao|S. W. Zeng|S. Dhar|E. Olsson|B. Gu|S. Yunoki|S. Maekawa|H. Hilgenkamp|T. Venkatesan|Ariando
  First page: 1838
  Abstract: Although LaAlO3 and SrTiO3 are both insulators, when they are brought together at a (100) interface, a highly conducting two-dimensional electron gas forms between them. Annandi et al. show that this also happens at a (110) interface, counter to expectations that it should not.
  Citation: Nature Communications 4, 1838 (2013)
  PubDate: 2013-05-14
  DOI: 10.1038/ncomms2804
  Issue No: Vol. 4 (2013)
Separation of neutral and charge modes in one-dimensional chiral edge channels
- Authors: E. Bocquillon|V. Freulon|J-.M Berroir|P. Degiovanni|B. Plaçais|A. Cavanna|Y. Jin|G. Fève
  First page: 1839
  Abstract: The Coulomb force between charges has a much greater influence on the electronic characteristics of 1D conductors than it does in 3D. Bocquillon et al. identify the separation of neutral and charged 1D edge modes, driven by Coulomb interactions in a quantum Hall system.
  Citation: Nature Communications 4, 1839 (2013)
  PubDate: 2013-05-14
  DOI: 10.1038/ncomms2788
  Issue No: Vol. 4 (2013)
Dendrogenin A arises from cholesterol and histamine metabolism and shows cell differentiation and anti-tumour properties
- Authors: Philippe de Medina|Michael R. Paillasse|Gregory Segala|Maud Voisin|Loubna Mhamdi|Florence Dalenc|Magali Lacroix-Triki|Thomas Filleron|Frederic Pont|Talal Al Saati|Christophe Morisseau|Bruce D. Hammock|Sandrine Silvente-Poirot|Marc Poirot
  First page: 1840
  Abstract: It has been hypothesized that the steroidal alkaloid dendrogenin A (DDA) is a natural metabolite. de Medina et al. show that DDA is produced in mammalian tissues from 5,6α-epoxy-cholesterol and histamine metabolism, and that the compound displays cell differentiation and anti-tumour activities.
  Citation: Nature Communications 4, 1840 (2013)
  PubDate: 2013-05-14
  DOI: 10.1038/ncomms2835
  Issue No: Vol. 4 (2013)
Quantum Faraday and Kerr rotations in graphene
- Authors: R. Shimano|G. Yumoto|J. Y. Yoo|R. Matsunaga|S. Tanabe|H. Hibino|T. Morimoto|H. Aoki
  First page: 1841
  Abstract: Graphene exhibits interesting optical and electronic properties, resulting from a Dirac dispersion of electrons. Shimano et al. observe quantum magneto-optical Faraday and Kerr effects in the terahertz regime, where plateaus are observed at the quantum-Hall steps.
  Citation: Nature Communications 4, 1841 (2013)
  PubDate: 2013-05-14
  DOI: 10.1038/ncomms2866
  Issue No: Vol. 4 (2013)
Photoconductive response in organic charge transfer interfaces with high quantum efficiency
- Authors: Helena Alves|Rui M. Pinto|Ermelinda S. Maçôas
  First page: 1842
  Abstract: Single-crystal organic semiconductors are potential materials for electronic applications, for example, as field-effect transistors. Here, the authors demonstrate photoconductivity of single-crystal charge-transfer interfaces, suggesting that they may also be used for photonic applications.
  Citation: Nature Communications 4, 1842 (2013)
  PubDate: 2013-05-14
  DOI: 10.1038/ncomms2890
  Issue No: Vol. 4 (2013)
Constitutively active Foxo3 in oocytes preserves ovarian reserve in mice
- Authors: Emanuele Pelosi|Shakib Omari|Marc Michel|Jun Ding|Tomokazu Amano|Antonino Forabosco|David Schlessinger|Chris Ottolenghi
  First page: 1843
  Abstract: The number of primordial follicles, which constitute the ovarian reserve, decreases with age. By overexpressing a constitutively active version of the transcription factor FOXO3, the authors increase the ovarian reserve and fertility in aging female mice.
  Citation: Nature Communications 4, 1843 (2013)
  PubDate: 2013-05-14
  DOI: 10.1038/ncomms2861
  Issue No: Vol. 4 (2013)
GATA simple sequence repeats function as enhancer blocker boundaries
- Authors: Ram P. Kumar|Jaya Krishnan|Narendra Pratap Singh|Lalji Singh|Rakesh K. Mishra
  First page: 1844
  Abstract: GATA simple sequence repeats (SSRs) are located throughout vertebrate genomes in a non-random fashion. The authors show that these act as enhancer blocker elements in both human cells and Drosophila, indicating a conserved function of GATA SSRs.
  Citation: Nature Communications 4, 1844 (2013)
  PubDate: 2013-05-14
  DOI: 10.1038/ncomms2872
  Issue No: Vol. 4 (2013)
Casimir forces on a silicon micromechanical chip
- Authors: J. Zou|Z. Marcet|A. W. Rodriguez|M. T. H. Reid|A. P. McCauley|I. I. Kravchenko|T. Lu|Y. Bao|S. G. Johnson|H. B. Chan
  First page: 1845
  Abstract: The Casimir effect is based on quantum electrodynamical effects between two electrically neutral objects in close proximity. Here Zou et al. observe the Casimir effect between two silicon components on a single micromechanical chip, allowing for an on-chip exploitation of the Casimir force.
  Citation: Nature Communications 4, 1845 (2013)
  PubDate: 2013-05-14
  DOI: 10.1038/ncomms2842
  Issue No: Vol. 4 (2013)
Prions disturb post-Golgi trafficking of membrane proteins
- Authors: Keiji Uchiyama|Naomi Muramatsu|Masashi Yano|Takeshi Usui|Hironori Miyata|Suehiro Sakaguchi
  First page: 1846
  Abstract: Prion protein accumulation in endosomal vesicles has been implicated in the progression of prion diseases. Uchiyama and colleagues infect neuronal cells with prion proteins and find that this delays post-Golgi vesicular trafficking of membrane proteins and impairs insulin signalling.
  Citation: Nature Communications 4, 1846 (2013)
  PubDate: 2013-05-14
  DOI: 10.1038/ncomms2873
  Issue No: Vol. 4 (2013)
InVERT molding for scalable control of tissue microarchitecture
- Authors: K. R. Stevens|M. D. Ungrin|R. E. Schwartz|S. Ng|B. Carvalho|K. S. Christine|R. R. Chaturvedi|C. Y. Li|P. W. Zandstra|C S Chen|S N Bhatia
  First page: 1847
  Abstract: Artificially engineered tissues may be useful for regenerative therapies but their fabrication tends to be complicated. Stevens et al. present a technique for the precise organization of microstructurally complex tissues that works with a variety of cell types and does not require sophisticated equipment.
  Citation: Nature Communications 4, 1847 (2013)
  PubDate: 2013-05-14
  DOI: 10.1038/ncomms2853
  Issue No: Vol. 4 (2013)
Picosecond pulses from wavelength-swept continuous-wave Fourier domain mode-locked lasers
- Authors: Christoph M. Eigenwillig|Wolfgang Wieser|Sebastian Todor|Benjamin R. Biedermann|Thomas Klein|Christian Jirauschek|Robert Huber
  First page: 1848
  Abstract: Ultrafast lasers are important in many fields of science, but they typically have high power consumption. Here Eigenwillig et al. realize picosecond laser pulses directly from a semiconductor-based laser. Due to the low repetition rate, high-energy pulses are generated at low average power.
  Citation: Nature Communications 4, 1848 (2013)
  PubDate: 2013-05-14
  DOI: 10.1038/ncomms2870
  Issue No: Vol. 4 (2013)
Coordinated activation of the Rac-GAP β2-chimaerin by an atypical proline-rich domain and diacylglycerol
- Authors: Alvaro Gutierrez-Uzquiza|Francheska Colon-Gonzalez|Thomas A. Leonard|Bertram J. Canagarajah|HongBin Wang|Bruce J. Mayer|James H. Hurley|Marcelo G. Kazanietz
  First page: 1849
  Abstract: Chimaerins are small GTPase-activating proteins that regulate Rac signalling in response to diacylglycerol. Here the authors discover that activation of β2-chimaerin requires an additional stimulus, in the form of an atypical interaction with the adaptor protein Nck.
  Citation: Nature Communications 4, 1849 (2013)
  PubDate: 2013-05-14
  DOI: 10.1038/ncomms2834
  Issue No: Vol. 4 (2013)
SUMO2/3 modification of cyclin E contributes to the control of replication origin firing
- Authors: Catherine Bonne-Andrea|Malik Kahli|Francisca Mechali|Jean-Marc Lemaitre|Guillaume Bossis|Olivier Coux
  First page: 1850
  Abstract: The organized initiation of DNA replication at sites throughout the genome must be carefully choreographed to maintain genome stability. Bonne-Andrea and colleagues show that protein SUMOylation controls the density of origin firing, and identify cyclin E as an important substrate in this context.
  Citation: Nature Communications 4, 1850 (2013)
  PubDate: 2013-05-14
  DOI: 10.1038/ncomms2875
  Issue No: Vol. 4 (2013)
An information-theoretic principle implies that any discrete physical theory is classical
- Authors: Corsin Pfister|Stephanie Wehner
  First page: 1851
  Abstract: Quantum mechanics dictates that the act of obtaining information about a system must disturb the system. Pfister and Wehner show that if the converse is also true—that no information gain implies no disturbance—then state space can only be discrete if it is classical.
  Citation: Nature Communications 4, 1851 (2013)
  PubDate: 2013-05-14
  DOI: 10.1038/ncomms2821
  Issue No: Vol. 4 (2013)
High doses of CpG oligodeoxynucleotides stimulate a tolerogenic TLR9–TRIF pathway
- Authors: Claudia Volpi|Francesca Fallarino|Maria T. Pallotta|Roberta Bianchi|Carmine Vacca|Maria L. Belladonna|Ciriana Orabona|Antonella De Luca|Louis Boon|Luigina Romani|Ursula Grohmann|Paolo Puccetti
  First page: 1852
  Abstract: CpG oligodeoxynucleotides stimulate innate immune signalling and are of significant interest as therapeutics. Here the authors show that at high doses, these molecules induce an opposite, tolerogenic effect, acting through a previously uncharacterized Toll-like receptor-dependent pathway.
  Citation: Nature Communications 4, 1852 (2013)
  PubDate: 2013-05-14
  DOI: 10.1038/ncomms2874
  Issue No: Vol. 4 (2013)
Primary tumours modulate innate immune signalling to create pre-metastatic vascular hyperpermeability foci
- Authors: Sachie Hiratsuka|Sachie Ishibashi|Takeshi Tomita|Akira Watanabe|Sachiko Akashi-Takamura|Masato Murakami|Hiroshi Kijima|Kensuke Miyake|Hiroyuki Aburatani|Yoshiro Maru
  First page: 1853
  Abstract: Tumours are thought to pave the way for metastases to distant organs by secreting factors create regions of increased vascular permeability. Hiratsuka et al. identify innate immune pathways that underlie this process in the pre-metastatic lungs of tumour-bearing mice and patients.
  Citation: Nature Communications 4, 1853 (2013)
  PubDate: 2013-05-14
  DOI: 10.1038/ncomms2856
  Issue No: Vol. 4 (2013)
Single-cell and metagenomic analyses indicate a fermentative and saccharolytic lifestyle for members of the OP9 lineage
- Authors: Jeremy A. Dodsworth|Paul C. Blainey|Senthil K. Murugapiran|Wesley D. Swingley|Christian A. Ross|Susannah G. Tringe|Patrick S. G. Chain|Matthew B. Scholz|Chien-Chi Lo|Jason Raymond|Stephen R. Quake|Brian P. Hedlund
  First page: 1854
  Abstract: OP9 is a yet-uncultivated bacterial lineage found in anaerobic environments. Dodsworth et al. use single-cell genomics and metagenomics to construct two near-complete OP9 genomes, revealing a fermentative metabolism and supporting the designation of OP9 as candidate phylum 'Atribacteria'.
  Citation: Nature Communications 4, 1854 (2013)
  PubDate: 2013-05-14
  DOI: 10.1038/ncomms2884
  Issue No: Vol. 4 (2013)
Selective isolation of gold facilitated by second-sphere coordination with α-cyclodextrin
- Authors: Zhichang Liu|Marco Frasconi|Juying Lei|Zachary J. Brown|Zhixue Zhu|Dennis Cao|Julien Iehl|Guoliang Liu|Albert C. Fahrenbach|Youssry Y. Botros|Omar K. Farha|Joseph T. Hupp|Chad A. Mirkin|J. Fraser Stoddart
  First page: 1855
  Abstract: Currently, gold recovery from waste materials requires inorganic cyanides and more environmentally benign methods are required. Here, the authors report that host–guest interactions between α-cyclodextrin and gold lead to the precipitation of one-dimensional superstructures, offering a selective and green alternative.
  Citation: Nature Communications 4, 1855 (2013)
  PubDate: 2013-05-14
  DOI: 10.1038/ncomms2891
  Issue No: Vol. 4 (2013)
A mutation in the receptor Methoprene-tolerant alters juvenile hormone response in insects and crustaceans
- Authors: Hitoshi Miyakawa|Kenji Toyota|Ikumi Hirakawa|Yukiko Ogino|Shinichi Miyagawa|Shigeto Oda|Norihisa Tatarazako|Toru Miura|John K. Colbourne|Taisen Iguchi
  First page: 1856
  Abstract: Juvenile hormone (JH) is a key regulator of development both in insects and the crustacea Daphnia pulex and D. magna. Here, Miyakawa et al. investigate the evolutionary significance of a single amino-acid variation between crustacea and insects in the JH receptor gene, Methoprene-tolerant.
  Citation: Nature Communications 4, 1856 (2013)
  PubDate: 2013-05-14
  DOI: 10.1038/ncomms2868
  Issue No: Vol. 4 (2013)
Periodic Wnt1 expression in response to ecdysteroid generates twin-spot markings on caterpillars
- Authors: Junichi Yamaguchi|Yutaka Banno|Kazuei Mita|Kimiko Yamamoto|Toshiya Ando|Haruhiko Fujiwara
  First page: 1857
  Abstract: Among various pigmentation patterns on caterpillars, sequential spot markings are often used for aposematic colouration. Fujiwara et al. show using genetic and functional analyses that periodic upregulation of Wnt1 in response to ecdysteroid causes twin-spot markings on lepidopteran larvae.
  Citation: Nature Communications 4, 1857 (2013)
  PubDate: 2013-05-14
  DOI: 10.1038/ncomms2778
  Issue No: Vol. 4 (2013)
Draft genome sequence of the Tibetan antelope
- Authors: Ri-Li Ge|Qingle Cai|Yong-Yi Shen|A San|Lan Ma|Yong Zhang|Xin Yi|Yan Chen|Lingfeng Yang|Ying Huang|Rongjun He|Yuanyuan Hui|Meirong Hao|Yue Li|Bo Wang|Xiaohua Ou|Jiaohui Xu|Yongfen Zhang|Kui Wu|Chunyu Geng|Weiping Zhou|Taicheng Zhou|David M. Irwin|Yingzhong Yang|Liu Ying|Haihua Bao|Jaebum Kim|Denis M. Larkin|Jian Ma|Harris A. Lewin|Jinchuan Xing|Roy N. Platt|David A. Ray|Loretta Auvil|Boris Capitanu|Xiufeng Zhang|Guojie Zhang|Robert W. Murphy|Jun Wang|Ya-Ping Zhang|Jian Wang
  First page: 1858
  Abstract: The endemic Tibetan antelope is adapted to high-altitude environments with low partial pressure of oxygen and high level of ultraviolet radiation. Here Ge et al. report a draft genome of this species and by comparison with other mammals, present possible genetic bases of highland adaptation.
  Citation: Nature Communications 4, 1858 (2013)
  PubDate: 2013-05-14
  DOI: 10.1038/ncomms2860
  Issue No: Vol. 4 (2013)
Flexible polymer transistors with high pressure sensitivity for application in electronic skin and health monitoring
- Authors: Gregor Schwartz|Benjamin C.-K. Tee|Jianguo Mei|Anthony L. Appleton|Do Hwan Kim|Huiliang Wang|Zhenan Bao
  First page: 1859
  Abstract: Flexible pressure sensors may be key in realising biomedical prostheses and robots that can interact with their environment. Here, Schwartz et al. report an organic thin film pressure sensing device that combines fast response times with low power consumption and cyclic stability.
  Citation: Nature Communications 4, 1859 (2013)
  PubDate: 2013-05-14
  DOI: 10.1038/ncomms2832
  Issue No: Vol. 4 (2013)
The genomics of selection in dogs and the parallel evolution between dogs and humans
- Authors: Guo-dong Wang|Weiwei Zhai|He-chuan Yang|Ruo-xi Fan|Xue Cao|Li Zhong|Lu Wang|Fei Liu|Hong Wu|Lu-guang Cheng|Andrei D. Poyarkov|Nikolai A. Poyarkov JR|Shu-sheng Tang|Wen-ming Zhao|Yun Gao|Xue-mei Lv|David M. Irwin|Peter Savolainen|Chung-i Wu|Ya-ping Zhang
  First page: 1860
  Abstract: Dogs may have been domesticated much earlier than previously thought, perhaps by initially scavenging with humans. Here Zhang et al. present genetic evidence that genes positively selected during dog domestication show extensive parallelism with human analogues.
  Citation: Nature Communications 4, 1860 (2013)
  PubDate: 2013-05-14
  DOI: 10.1038/ncomms2814
  Issue No: Vol. 4 (2013)
A European population in Minoan Bronze Age Crete
- Authors: Jeffery R. Hughey|Peristera Paschou|Petros Drineas|Donald Mastropaolo|Dimitra M. Lotakis|Patrick A. Navas|Manolis Michalodimitrakis|John A. Stamatoyannopoulos|George Stamatoyannopoulos
  First page: 1861
  Abstract: 5,000 years ago, the Minoans established the first advanced civilization of Europe, but their origin remains unclear. Here the authors show that the Minoans were a European population, genetically similar to other ancient European populations and to the present inhabitants of the island of Crete.
  Citation: Nature Communications 4, 1861 (2013)
  PubDate: 2013-05-14
  DOI: 10.1038/ncomms2871
  Issue No: Vol. 4 (2013)
Clusterin and LRP2 are critical components of the hypothalamic feeding regulatory pathway
- Authors: So Young Gil|Byung-Soo Youn|Kyunghee Byun|Hu Huang|Churl Namkoong|Pil-Geum Jang|Joo-Yong Lee|Young-Hwan Jo|Gil Myoung Kang|Hyun-Kyong Kim|Mi-Seon Shin|Claus U. Pietrzik|Bonghee Lee|Young-Bum Kim|Min-Seon Kim
  First page: 1862
  Abstract: Clusterin is widely distributed in tissues and body fluids, and is implicated in various physiological processes. In this study the authors investigate the role of hypothalamic clusterin, and find that clusterin regulates energy metabolism and body weight through the lipoprotein receptor LRP2.
  Citation: Nature Communications 4, 1862 (2013)
  PubDate: 2013-05-14
  DOI: 10.1038/ncomms2896
  Issue No: Vol. 4 (2013)
A protein phosphatase 2A complex spatially controls plant cell division
- Authors: Lara Spinner|Astrid Gadeyne|Katia Belcram|Magali Goussot|Michaël Moison|Yann Duroc|Dominique Eeckhout|Nancy De Winne|Estelle Schaefer|Eveline Van De Slijke|Geert Persiau|Erwin Witters|Kris Gevaert|Geert De Jaeger|David Bouchez|Daniël Van Damme|Martine Pastuglia
  First page: 1863
  Abstract: Spatial positioning of the division plane in plant cells is determined premitotically by the preprophase band of microtubules. Spinner et al. show that its formation in Arabidopsis requires a PP2A complex containing FASS and TON1 which is recruited to cortical microtubules by the TRM protein family.
  Citation: Nature Communications 4, 1863 (2013)
  PubDate: 2013-05-14
  DOI: 10.1038/ncomms2831
  Issue No: Vol. 4 (2013)
Transcription factor binding kinetics constrain noise suppression via negative feedback
- Authors: Andreas Grönlund|Per Lötstedt|Johan Elf
  First page: 1864
  Abstract: Live cell imaging have recently revealed that transcription factors spend up to 4 min to find and bind their chromosomal binding site. Grönlund et al. show that this slow search process leads to tradeoffs between strength and speed of negative autoregulation for effective noise suppression.
  Citation: Nature Communications 4, 1864 (2013)
  PubDate: 2013-05-14
  DOI: 10.1038/ncomms2867
  Issue No: Vol. 4 (2013)
Controlled formation and reflection of a bright solitary matter-wave
- Authors: A. L. Marchant|T. P. Billam|T. P. Wiles|M. M. H. Yu|S. A. Gardiner|S. L. Cornish
  First page: 1865
  Abstract: Bright solitary waves in Bose–Einstein condensates are analogues of solitons in conventional wave systems, and may enable interesting tests of many-body quantum systems. Using 85Rb, Marchant et al. show the controlled formation of bright solitary matter-waves, and their reflection from a repulsive barrier.
  Citation: Nature Communications 4, 1865 (2013)
  PubDate: 2013-05-14
  DOI: 10.1038/ncomms2893
  Issue No: Vol. 4 (2013)
Magnetically ultraresponsive nanoscavengers for next-generation water purification systems
- Authors: Mingliang Zhang|Xing Xie|Mary Tang|Craig S. Criddle|Yi Cui|Shan X. Wang
  First page: 1866
  Abstract: Silver nanoparticles are useful antimicrobial agents in water purification systems. Here the fabrication of silver nanoparticles that include a magnetic layer could lead to improved purification systems as it allows the recovery of the nanoparticles by magnetic fields.
  Citation: Nature Communications 4, 1866 (2013)
  PubDate: 2013-05-14
  DOI: 10.1038/ncomms2892
  Issue No: Vol. 4 (2013)
Delivery of therapeutic agents by nanoparticles made of grapefruit-derived lipids
- Authors: Qilong Wang|Xiaoying Zhuang|Jingyao Mu|Zhong-Bin Deng|Hong Jiang|Xiaoyu Xiang|Baomei Wang|Jun Yan|Donald Miller|Huang-Ge Zhang
  First page: 1867
  Abstract: Nanoparticles released from living cells can be used as drug delivery vehicles, but scaling up their production is challenging. Here, Wang and colleagues create nanoparticles from natural lipids contained in grapefruit juice that can encapsulate various types of therapeutics and deliver them to cells in vitro and in vivo.
  Citation: Nature Communications 4, (2013)
  PubDate: 2013-05-21
  DOI: 10.1038/ncomms2886
  Issue No: Vol. 4 (2013)
Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model
- Authors: Baohua Liu|Zimei Wang|Le Zhang|Shrestha Ghosh|Huiling Zheng|Zhongjun Zhou
  First page: 1868
  Abstract: Accelerated cellular ageing in patients with progeria can be caused by the accumulation of nuclear lamins, leading to DNA damage and histone methylation. Here Liu et al. show that the metyltransferase SUV39H1 regulates lamin A stability, and that SUV39H1 depletion extends lifespan in a progeria mouse model.
  Citation: Nature Communications 4, 1868 (2013)
  PubDate: 2013-05-21
  DOI: 10.1038/ncomms2885
  Issue No: Vol. 4 (2013)
Focusing light with a flame lens
- Authors: Max M. Michaelis|Cosmas Mafusire|Jan-Hendrik Grobler|Andrew Forbes
  First page: 1869
  Abstract: Lenses are well-understood optical instruments to focus light. The flame lens realized here by Michaelis et al. offers light focusing with a damage threshold several orders of magnitude higher than that of most conventional lenses.
  Citation: Nature Communications 4, 1869 (2013)
  PubDate: 2013-05-21
  DOI: 10.1038/ncomms2894
  Issue No: Vol. 4 (2013)
Direct atomic-scale confirmation of three-phase storage mechanism in Li4Ti5O12 anodes for room-temperature sodium-ion batteries
- Authors: Yang Sun|Liang Zhao|Huilin Pan|Xia Lu|Lin Gu|Yong-Sheng Hu|Hong Li|Michel Armand|Yuichi Ikuhara|Liquan Chen|Xuejie Huang
  First page: 1870
  Abstract: The development of suitable anode materials for room-temperature sodium-ion batteries remains a challenging issue. Sun et al. show that the well-known zero-strain Li4Ti5O12 anode for lithium storage is capable of reversibly hosting sodium ions via a three-phase storage mechanism.
  Citation: Nature Communications 4, 1870 (2013)
  PubDate: 2013-05-21
  DOI: 10.1038/ncomms2878
  Issue No: Vol. 4 (2013)
Tribbles 3 mediates endoplasmic reticulum stress-induced insulin resistance in skeletal muscle
- Authors: Ho-Jin Koh|Taro Toyoda|Michelle M. Didesch|Min-Young Lee|Mark W. Sleeman|Rohit N. Kulkarni|Nicolas Musi|Michael F Hirshman|Laurie J. Goodyear
  First page: 1871
  Abstract: Endoplasmic reticulum (ER) stress is observed in diabetes and has been linked to insulin resistance in various tissues. Here, Koh and colleagues show the protein Tribbles 3, which is induced by ER stress and obesity in mice and humans, is an inhibitor of insulin signalling in skeletal muscle.
  Citation: Nature Communications 4, 1871 (2013)
  PubDate: 2013-05-21
  DOI: 10.1038/ncomms2851
  Issue No: Vol. 4 (2013)
The pore of voltage-gated potassium ion channels is strained when closed
- Authors: Philip W. Fowler|Mark S. P. Sansom
  First page: 1872
  Abstract: Voltage-gated potassium channels open and close in response to changes in transmembrane potential, but their opening mechanism is poorly understood. Here, free energy molecular dynamics simulations show that strain accumulates as the pore closes, which subsequently drives opening.
  Citation: Nature Communications 4, 1872 (2013)
  PubDate: 2013-05-21
  DOI: 10.1038/ncomms2858
  Issue No: Vol. 4 (2013)
Controlled multi-vinyl monomer homopolymerization through vinyl oligomer combination as a universal approach to hyperbranched architectures
- Authors: Tianyu Zhao|Yu Zheng|Julien Poly|Wenxin Wang
  First page: 1873
  Abstract: Hyperbranched polymers have desirable properties as novel materials, and may be synthesized from homopolymerization of multi-vinyl momomers, although this can form insoluble products at low conversions. Here, the authors produce hyperbranched polymers in high yield owing to a kinetic control mechanism.
  Citation: Nature Communications 4, 1873 (2013)
  PubDate: 2013-05-21
  DOI: 10.1038/ncomms2887
  Issue No: Vol. 4 (2013)
Stimuli-responsive selection of target DNA sequences by synthetic bZIP peptides
- Authors: Jesús Mosquera|Adrián Jiménez-Balsa|Verónica I Dodero|M Eugenio Vázquez|José L Mascareñas
  First page: 1874
  Abstract: The expression of specific genes can be controlled by the combination of DNA-binding proteins, which determines their binding site selectivity. Here, simplified synthetic basic region leucine zipper-based peptides are induced to dimerize either through their C- or N-terminus, and thus are targeted to different DNA sequences.
  Citation: Nature Communications 4, 1874 (2013)
  PubDate: 2013-05-21
  DOI: 10.1038/ncomms2825
  Issue No: Vol. 4 (2013)
Assembly of a π–π stack of ligands in the binding site of an acetylcholine-binding protein
- Authors: Mariano Stornaiuolo|Gerdien E. De Kloe|Prakash Rucktooa|Alexander Fish|René van Elk|Ewald S. Edink|Daniel Bertrand|August B. Smit|Iwan J. P. de Esch|Titia K. Sixma
  First page: 1875
  Abstract: AChBP is used as a structurally accessible prototype for studying ligand binding to nicotinic acetylcholine receptors. Stornaiuolo et al. report that a small molecule binds AChBP in an ordered p–p stack of three molecules per binding site, which may lead to new approaches in drug design.
  Citation: Nature Communications 4, 1875 (2013)
  PubDate: 2013-05-21
  DOI: 10.1038/ncomms2900
  Issue No: Vol. 4 (2013)
Distinct pathways mediate axon degeneration during apoptosis and axon-specific pruning
- Authors: Corey L. Cusack|Vijay Swahari|W. Hampton Henley|J. Michael Ramsey|Mohanish Deshmukh
  First page: 1876
  Abstract: Recent studies suggest that there is an overlap between neuronal apoptosis and axon-specific degeneration. Cusack and colleagues show that the caspase-dependent pathways mediating axon degeneration during apoptosis are distinct from those mediating localized axon pruning.
  Citation: Nature Communications 4, 1876 (2013)
  PubDate: 2013-05-21
  DOI: 10.1038/ncomms2910
  Issue No: Vol. 4 (2013)
MicroRNA-135b promotes lung cancer metastasis by regulating multiple targets in the Hippo pathway and LZTS1
- Authors: Ching-Wen Lin|Yih-Leong Chang|Yu-Chiuan Chang|Jau-Chen Lin|Chun-Chi Chen|Szu-Hua Pan|Chen-Tu Wu|Hsuan-Yu Chen|Shuenn-Chen Yang|Tse-Ming Hong|Pan-Chyr Yang
  First page: 1877
  Abstract: Lung cancers have a high potential to become metastatic, which is a major cause of treatment failure. Here, the authors identify a microRNA that is upregulated in non-small-cell lung cancer and is associated with Hippo pathway modulation metastasis and poor clinical outcome.
  Citation: Nature Communications 4, 1877 (2013)
  PubDate: 2013-05-21
  DOI: 10.1038/ncomms2876
  Issue No: Vol. 4 (2013)
Direct imaging of single UvrD helicase dynamics on long single-stranded DNA
- Authors: Kyung Suk Lee|Hamza Balci|Haifeng Jia|Timothy M. Lohman|Taekjip Ha
  First page: 1878
  Abstract: Tracking single molecules on long stretches of single-stranded DNA poses technical challenges due to its propensity to form hairpin structures. To solve this problem, the authors combine TIRF microscopy with optical tweezers to stretch the DNA and capture the dynamics of DNA unwinding by UvrD DNA helicase.
  Citation: Nature Communications 4, 1878 (2013)
  PubDate: 2013-05-21
  DOI: 10.1038/ncomms2882
  Issue No: Vol. 4 (2013)
Taller plants have lower rates of molecular evolution
- Authors: Robert Lanfear|Simon Y. W. Ho|T. Jonathan Davies|Angela T. Moles|Lonnie Aarssen|Nathan G. Swenson|Laura Warman|Amy E. Zanne|Andrew P. Allen
  First page: 1879
  Abstract: Rates of molecular evolution vary significantly between species, but the reasons behind this variation remain unclear. Lanfear et al. show that height accounts for one-fifth of the rate variation measured in plant genomes, and suggest that is because taller plants copy their genomes less frequently.
  Citation: Nature Communications 4, 1879 (2013)
  PubDate: 2013-05-21
  DOI: 10.1038/ncomms2836
  Issue No: Vol. 4 (2013)
Formin mDia1 senses and generates mechanical forces on actin filaments
- Authors: Antoine Jégou|Marie-France Carlier|Guillaume Romet-Lemonne
  First page: 1883
  Abstract: Formins are a family of protein complexes that accelerate actin filament nucleation and elongation. Jegou et al. show that the formin mDia1 can generate mechanical tension in actin filaments, while conversely, pulling forces applied by viscous drag increase formin elongation activity.
  Citation: Nature Communications 4, 1883 (2013)
  PubDate: 2013-05-21
  DOI: 10.1038/ncomms2888
  Issue No: Vol. 4 (2013)
Distinct bone marrow-derived and tissue-resident macrophage lineages proliferate at key stages during inflammation
- Authors: Luke C. Davies|Marcela Rosas|Stephen J. Jenkins|Chia-Te Liao|Martin J. Scurr|Frank Brombacher|Donald J. Fraser|Judith E. Allen|Simon A. Jones|Philip R. Taylor
  First page: 1886
  Abstract: Monocytes are recruited to sites of damage or infection where they differentiate into inflammatory macrophages. Here the authors demonstrate that, contrary to the prevailing model, these differentiated cells are able to proliferate at sites of inflammation.
  Citation: Nature Communications 4, 1886 (2013)
  PubDate: 2013-05-21
  DOI: 10.1038/ncomms2877
  Issue No: Vol. 4 (2013)
Ice nucleation at the nanoscale probes no man’s land of water
- Authors: Tianshu Li|Davide Donadio|Giulia Galli
  First page: 1887
  Abstract: Nucleation and growth of ice in small droplets are strongly size dependent, but direct experimental evidence is rare. Li et al. demonstrate computationally that the nucleation is substantially suppressed in nanosized droplets, which is caused by increased pressure at the curved liquid–vapour interface.
  Citation: Nature Communications 4, 1887 (2013)
  PubDate: 2013-05-21
  DOI: 10.1038/ncomms2918
  Issue No: Vol. 4 (2013)
Crystal structures of interleukin 17A and its complex with IL-17 receptor A
- Authors: Shenping Liu|Xi Song|Boris A. Chrunyk|Suman Shanker|Lise R. Hoth|Eric S. Marr|Matthew C. Griffor
  First page: 1888
  Abstract: Interleukin-17A homodimers preferentially interact with heterodimeric IL-17 receptors. By solving the crystal structure of an IL-17A homodimer in complex with a single IL-17RA receptor subunit, the authors reveal conformational changes in IL-17A that lead to exclusion of a second IL-17RA subunit.
  Citation: Nature Communications 4, 1888 (2013)
  PubDate: 2013-05-21
  DOI: 10.1038/ncomms2880
  Issue No: Vol. 4 (2013)
NMR structure of human restriction factor APOBEC3A reveals substrate binding and enzyme specificity
- Authors: In-Ja L. Byeon|Jinwoo Ahn|Mithun Mitra|Chang-Hyeock Byeon|Kamil Hercík|Jozef Hritz|Lisa M. Charlton|Judith G. Levin|Angela M. Gronenborn
  First page: 1890
  Abstract: The cytidine deaminase APOBEC3A has potent antiviral activity, degrading foreign DNA, and inhibiting viral replication, retrotransposition and reverse transcription. Byeon et al. present the solution structure of APOBEC3A, and reveal insights into its substrate specificity.
  Citation: Nature Communications 4, 1890 (2013)
  PubDate: 2013-05-21
  DOI: 10.1038/ncomms2883
  Issue No: Vol. 4 (2013)
Mechanistic and environmental control of the prevalence and lifetime of amyloid oligomers
- Authors: Ryan J. Morris|Kym Eden|Reuben Yarwood|Line Jourdain|Rosalind J. Allen|Cait E. MacPhee
  First page: 1891
  Abstract: Amyloid fibrils are implicated in a number of diseases but the origin of their length distributions is poorly understood. Here, evidence is presented to support a structural transition at a critical mass concentration, above which fragmentation of fibrils is suppressed.
  Citation: Nature Communications 4, 1891 (2013)
  PubDate: 2013-05-21
  DOI: 10.1038/ncomms2909
  Issue No: Vol. 4 (2013)
Amorphous nickel hydroxide nanospheres with ultrahigh capacitance and energy density as electrochemical pseudocapacitor materials
- Authors: H. B. Li|M. H. Yu|F. X. Wang|P. Liu|Y. Liang|J. Xiao|C. X. Wang|Y. X. Tong|G. W. Yang
  First page: 1894
  Abstract: Nickel hydroxide is a promising material for capacitor electrodes and most research has focussed on the crystalline form. Here, the authors report that amorphous nickel hydroxide nanospheres, which may be synthesized relatively easily, also exhibit excellent integrated electrochemical performance.
  Citation: Nature Communications 4, 1894 (2013)
  PubDate: 2013-05-21
  DOI: 10.1038/ncomms2932
  Issue No: Vol. 4 (2013)
Gravity-induced encapsulation of liquids by destabilization of granular rafts
- Authors: Manouk Abkarian|Suzie Protière|Jeffrey M. Aristoff|Howard A. Stone
  First page: 1895
  Abstract: Removing oil from the top of water in an efficient way remains a technical challenge in various environmental settings. Abkarian et al. show an approach to cover oil droplets with natural sands driven by gravity, which leads to a spontaneous separation of oil from water.
  Citation: Nature Communications 4, 1895 (2013)
  PubDate: 2013-05-21
  DOI: 10.1038/ncomms2869
  Issue No: Vol. 4 (2013)
High-performance rechargeable lithium-iodine batteries using triiodide/iodide redox couples in an aqueous cathode
- Authors: Yu Zhao|Lina Wang|Hye Ryung Byon
  First page: 1896
  Abstract: Aqueous lithium batteries can store more energy because of their high ionic conductivity compared with the all-solid-state or non-aqueous electrolyte based counterparts. Zhao et al. report a large energy storage density by using safe and low-cost triiodide/iodide redox reaction in an aqueous cathode.
  Citation: Nature Communications 4, 1896 (2013)
  PubDate: 2013-05-21
  DOI: 10.1038/ncomms2907
  Issue No: Vol. 4 (2013)
Influence of microstructure on superconductivity in KxFe2−ySe2 and evidence for a new parent phase K2Fe7Se8
- Authors: Xiaxin Ding|Delong Fang|Zhenyu Wang|Huan Yang|Jianzhong Liu|Qiang Deng|Guobin Ma|Chong Meng|Yuhui Hu|Hai-Hu Wen
  First page: 1897
  Abstract: The structure of the superconducting phase of iron-based superconductor KxFe2−ySe2 is difficult to determine because it coexists with an predominant insulating phase. Ding et al. identify the superconducting filaments that provide clues to the structure of the parent phase of superconductivity.
  Citation: Nature Communications 4, 1897 (2013)
  PubDate: 2013-05-21
  DOI: 10.1038/ncomms2913
  Issue No: Vol. 4 (2013)
R-Spondin 2 signalling mediates susceptibility to fatal infectious diarrhoea
- Authors: Olivier Papapietro|Sarah Teatero|Ajitha Thanabalasuriar|Kyoko E. Yuki|Eduardo Diez|Lei Zhu|Eugene Kang|Sandeep Dhillon|Aleixo M. Muise|Yves Durocher|Martin M. Marcinkiewicz|Danielle Malo|Samantha Gruenheid
  First page: 1898
  Abstract: Citrobacter rodentium is an intestinal pathogen of mice widely used to model enteropathogenic E. coli infection in humans. Using a forward genetic approach, Papapietro and colleagues identify R-Spondin 2 expression and resulting Wnt signalling activation as a major regulator of C. rodentium-induced colitis.
  Citation: Nature Communications 4, 1898 (2013)
  PubDate: 2013-05-21
  DOI: 10.1038/ncomms2816
  Issue No: Vol. 4 (2013)
Structural phase transformations in metallic grain boundaries
- Authors: Timofey Frolov|David L. Olmsted|Mark Asta|Yuri Mishin
  First page: 1899
  Abstract: Grain boundaries have an important role in determining the properties of polycrystalline materials but little has been known about changes in their atomic structure. Timofey Frolov and colleagues show that variations in atomic density in a boundary can produce different and unexpected boundary structures.
  Citation: Nature Communications 4, 1899 (2013)
  PubDate: 2013-05-21
  DOI: 10.1038/ncomms2919
  Issue No: Vol. 4 (2013)
An influenza virus-inspired polymer system for the timed release of siRNA
- Authors: Nghia P Truong|Wenyi Gu|Indira Prasadam|Zhongfan Jia|Ross Crawford|Yin Xiao|Michael J Monteiro
  First page: 1902
  Abstract: Small interfering RNA is degraded by plasma and can’t cross the cell membrane due to its negative charge. Here, the authors present an influenza inspired polymer carrier, capable of local RNA delivery, which degrades to a non-toxic by-product, and is thus suitable for multiple doses.
  Citation: Nature Communications 4, 1902 (2013)
  PubDate: 2013-05-21
  DOI: 10.1038/ncomms2905
  Issue No: Vol. 4 (2013)
Thermally assisted quantum annealing of a 16-qubit problem
- Authors: N G Dickson|M W Johnson|M H Amin|R Harris|F Altomare|A J Berkley|P Bunyk|J Cai|E M Chapple|P Chavez|F Cioata|T Cirip|P deBuen|M Drew-Brook|C Enderud|S Gildert|F Hamze|J P Hilton|E Hoskinson|K Karimi|E Ladizinsky|N Ladizinsky|T Lanting|T Mahon|R Neufeld|T Oh|I Perminov|C Petroff|A Przybysz|C Rich|P Spear|A Tcaciuc|M C Thom|E Tolkacheva|S Uchaikin|J Wang|A B Wilson|Z Merali|G Rose
  First page: 1903
  Abstract: Quantum annealing is one strategy that may enable quantum computations that are robust to noise, despite the system’s interaction with the environment. Dickson et al. explore quantum annealing for a 16-qubit system and find that for a small energy-gap avoided crossing, it can be robust against thermal noise.
  Citation: Nature Communications 4, 1903 (2013)
  PubDate: 2013-05-21
  DOI: 10.1038/ncomms2920
  Issue No: Vol. 4 (2013)
Monodisperse silicon nanocavities and photonic crystals with magnetic response in the optical region
- Authors: Lei Shi|Justin T Harris|Roberto Fenollosa|Isabelle Rodriguez|Xiaotang Lu|Brian A Korgel|Francisco Meseguer
  First page: 1904
  Abstract: Metamaterials offer optical functionality, such as cloaking, that is impossible to achieve with natural bulk materials. Here, Shi and colleagues fabricate colloidal metamaterials made from silicon whose magneto-optical response considerably exceeds that of related bulk materials.
  Citation: Nature Communications 4, 1904 (2013)
  PubDate: 2013-05-21
  DOI: 10.1038/ncomms2934
  Issue No: Vol. 4 (2013)
Development of Middle Stone Age innovation linked to rapid climate change
- Authors: Martin Ziegler|Margit H. Simon|Ian R. Hall|Stephen Barker|Chris Stringer|Rainer Zahn
  First page: 1905
  Abstract: The South African archaeological record contains evidence of the early flourishing of the human mind. Ziegler et al. provide new paleoclimate reconstructions, which suggest that rapid fluctuations in global climate have played a key role in the evolution of these early human cultures.
  Citation: Nature Communications 4, 1905 (2013)
  PubDate: 2013-05-21
  DOI: 10.1038/ncomms2897
  Issue No: Vol. 4 (2013)
Prothymosin α overexpression contributes to the development of pulmonary emphysema
- Authors: Bing-Hua Su|Yau-Lin Tseng|Gia-Shing Shieh|Yi-Cheng Chen|Ya-Chieh Shiang|Pensee Wu|Kuo-Jung Li|Te-Hsin Yen|Ai-Li Shiau|Chao-Liang Wu
  First page: 1906
  Abstract: Pulmonary emphysema obstruct airflow in the lung and often develop in smokers. Here Su et al. show that prothymosin α contributes to emphysema development through alterations in the acetylation of histones and the transcription factor NF-κB, and that exposure to cigarette smoke increases prothymosin α expression.
  Citation: Nature Communications 4, 1906 (2013)
  PubDate: 2013-05-21
  DOI: 10.1038/ncomms2906
  Issue No: Vol. 4 (2013)
Crocodylian diversity peak and extinction in the late Cenozoic of the northern Neotropics
- Authors: T. M. Scheyer|O. A. Aguilera|M. Delfino|D. C. Fortier|A. A. Carlini|R. Sánchez|J. D. Carrillo-Briceño|L. Quiroz|M. R. Sánchez-Villagra
  First page: 1907
  Abstract: Modern crocodylian diversity is in decline and sympatry is rare, with usually no more than two or three species occurring in the same geographic area. Here Scheyer et al. identify a diversity peak in sympatric occurrence of at least seven new and previously characterized crocodylian species during the Miocene in South America.
  Citation: Nature Communications 4, 1907 (2013)
  PubDate: 2013-05-21
  DOI: 10.1038/ncomms2940
  Issue No: Vol. 4 (2013)