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PHYSICS (578 journals)

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Journal Cover Nature Communications
  [SJR: 6.539]   [H-I: 114]   [166 followers]  Follow
    
  This is an Open Access Journal Open Access journal
   ISSN (Online) 2041-1723
   Published by NPG Homepage  [123 journals]
  • Synthesis of spiro quasi[1]catenanes and quasi[1]rotaxanes via a templated
           backfolding strategy
    • Synthesis of spiro quasi[1]catenanes and quasi[1]rotaxanes via a templated backfolding strategy

      Nature Communications, Published online: 25 May 2017; doi:10.1038/ncomms15392

      Spiro compounds contain two or more rings linked together through one common atom. Here the authors provide a method to backfold both rings, producing spiro quasi[1]catenanes, via a strategy of temporarily linking the linear intermediates with covalent bonds.

      Nature Communications, Published online: 25 May 2017; doi:10.1038/ncomms153922017-05-25
      DOI: 10.1038/ncomms15392
       
  • High pressure synthesis of a hexagonal close-packed phase of the
           high-entropy alloy CrMnFeCoNi
    • High pressure synthesis of a hexagonal close-packed phase of the high-entropy alloy CrMnFeCoNi

      Nature Communications, Published online: 25 May 2017; doi:10.1038/ncomms15634

      High-entropy alloys represent a new strategy for the design of materials with properties superior to those of conventional alloys, but are largely limited to simple phases of cubic symmetry. By applying high pressures on CrMnFeCoNi, here authors demonstrate synthesis of a hexagonal close-packed phase.

      Nature Communications, Published online: 25 May 2017; doi:10.1038/ncomms156342017-05-25
      DOI: 10.1038/ncomms15634
       
  • A reaction mode of carbene-catalysed aryl aldehyde activation and induced
           phenol OH functionalization
    • A reaction mode of carbene-catalysed aryl aldehyde activation and induced phenol OH functionalization

      Nature Communications, Published online: 25 May 2017; doi:10.1038/ncomms15598

      Selective functionalization of aromatic compounds is important in synthetic chemistry. Here the authors report an N-heterocyclic carbene-catalysed approach for enantioselectively converting ortho-hydroxyaldehydes to cyclic products, via activation of both phenol and aldehyde groups.

      Nature Communications, Published online: 25 May 2017; doi:10.1038/ncomms155982017-05-25
      DOI: 10.1038/ncomms15598
       
  • The long noncoding RNA lnc-EGFR stimulates T-regulatory cells
           differentiation thus promoting hepatocellular carcinoma immune evasion
    • The long noncoding RNA lnc-EGFR stimulates T-regulatory cells differentiation thus promoting hepatocellular carcinoma immune evasion

      Nature Communications, Published online: 25 May 2017; doi:10.1038/ncomms15129

      The role of long noncoding RNAs in regulating T-cell differentiation within the tumour microenvironment is unclear. Here the authors identify a lncRNA that, through direct interactions with EGFR, promotes T-regulatory cell differentiation within the microenvironment of hepatocellular carcinoma, thus promoting tumour growth via immune suppression.

      Nature Communications, Published online: 25 May 2017; doi:10.1038/ncomms151292017-05-25
      DOI: 10.1038/ncomms15129
       
  • Digital logic circuits in yeast with CRISPR-dCas9 NOR gates
    • Digital logic circuits in yeast with CRISPR-dCas9 NOR gates

      Nature Communications, Published online: 25 May 2017; doi:10.1038/ncomms15459

      The leakiness of commonly used genetic components can make the construction of complex synthetic circuits difficult. Here the authors construct NOR gate architecture, using dCas9 fused to the chromatin remodeller Mxi1, that can be wired together into complex circuits.

      Nature Communications, Published online: 25 May 2017; doi:10.1038/ncomms154592017-05-25
      DOI: 10.1038/ncomms15459
       
  • Coordination of cortical and thalamic activity during non-REM sleep in
           humans
    • Coordination of cortical and thalamic activity during non-REM sleep in humans

      Nature Communications, Published online: 25 May 2017; doi:10.1038/ncomms15499

      During non-REM sleep, the thalamus produces spindles and the cortex produces downstates, but the interaction between these two areas in these sleep phenomena is not understood. Here, authors describe the dynamic loop between the thalamus and cortex that organizes the production of spindles and downstates in the human brain.

      Nature Communications, Published online: 25 May 2017; doi:10.1038/ncomms154992017-05-25
      DOI: 10.1038/ncomms15499
       
  • Impaired prosaposin lysosomal trafficking in frontotemporal lobar
           degeneration due to progranulin mutations
    • Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations

      Nature Communications, Published online: 25 May 2017; doi:10.1038/ncomms15277

      Mutations in the granulin gene are associated with frontotemporal lobe dementia (FTLD) and a lysosomal storage disease. The authors show that reduced progranulin levels leads to impaired neuronal uptake and lysosomal delivery of prosaposin, and that decreased prosaposin expression in mice leads to FTLD-like behaviour.

      Nature Communications, Published online: 25 May 2017; doi:10.1038/ncomms152772017-05-25
      DOI: 10.1038/ncomms15277
       
  • Modeling the process of human tumorigenesis
    • Modeling the process of human tumorigenesis

      Nature Communications, Published online: 25 May 2017; doi:10.1038/ncomms15422

      A better understanding of the earliest stages of human cancer formation can enable future improvements in early detection, diagnosis and treatment. In this review, the authors summarize the methods enabling de novo tumorigenesis protocols to be applied to human cells and the insights derived from them to date, as well as the exciting and relevant technical developments anticipated to extend even further the utility of these strategies.

      Nature Communications, Published online: 25 May 2017; doi:10.1038/ncomms154222017-05-25
      DOI: 10.1038/ncomms15422
       
 
 
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