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PHYSICS (554 journals)            First | 1 2 3 4 5 6 | Last

Optical Communications and Networking, IEEE/OSA Journal of     Hybrid Journal   (Followers: 4)
Optofluidics, Microfluidics and Nanofluidics     Open Access  
Organic Electronics     Hybrid Journal   (Followers: 3)
Organic Photonics and Photovoltaics     Open Access   (Followers: 2)
PAJ: A Journal of Performance and Art     Hybrid Journal   (Followers: 11)
Particle Physics Insights     Open Access   (Followers: 2)
Particuology     Hybrid Journal  
Pattern Recognition in Physics     Open Access   (Followers: 1)
Pergamon Materials Series     Full-text available via subscription  
Phase Transitions and Critical Phenomena     Full-text available via subscription   (Followers: 1)
Philosophical Magazine     Hybrid Journal   (Followers: 2)
Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences     Full-text available via subscription   (Followers: 5)
Philosophy and Foundations of Physics     Full-text available via subscription  
Physica B: Condensed Matter     Hybrid Journal   (Followers: 5)
physica status solidi (a)     Hybrid Journal   (Followers: 1)
physica status solidi (b)     Hybrid Journal   (Followers: 1)
physica status solidi (c)     Hybrid Journal   (Followers: 1)
Physica Status Solidi - Rapid Research Letters     Hybrid Journal   (Followers: 1)
Physical Communication     Hybrid Journal  
Physical Review C     Full-text available via subscription   (Followers: 18)
Physical Review Special Topics - Physics Education Research     Open Access   (Followers: 6)
Physical Review X     Open Access   (Followers: 5)
Physical Sciences Data     Full-text available via subscription   (Followers: 1)
Physics - spotlighting exceptional research     Full-text available via subscription   (Followers: 1)
Physics and Chemistry of Glasses - European Journal of Glass Science and Technology Part B     Full-text available via subscription   (Followers: 2)
Physics and Chemistry of Liquids: An International Journal     Hybrid Journal   (Followers: 2)
Physics and Chemistry of the Earth, Parts A/B/C     Hybrid Journal   (Followers: 3)
Physics and Materials Chemistry     Open Access  
Physics Essays     Full-text available via subscription  
Physics in Medicine & Biology     Full-text available via subscription   (Followers: 9)
Physics in Perspective     Hybrid Journal   (Followers: 1)
Physics International     Open Access   (Followers: 2)
Physics Letters A     Hybrid Journal   (Followers: 10)
Physics Letters B     Open Access   (Followers: 3)
Physics of Fluids     Hybrid Journal   (Followers: 24)
Physics of Life Reviews     Hybrid Journal   (Followers: 1)
Physics of Plasmas     Hybrid Journal   (Followers: 6)
Physics of the Dark Universe     Open Access  
Physics of the Solid State     Hybrid Journal   (Followers: 3)
Physics of Wave Phenomena     Hybrid Journal   (Followers: 1)
Physics Procedia     Partially Free   (Followers: 1)
Physics Reports     Full-text available via subscription   (Followers: 2)
Physics Research International     Open Access   (Followers: 1)
Physics Today     Hybrid Journal   (Followers: 20)
Physics World     Full-text available via subscription   (Followers: 3)
Physics-Uspekhi     Full-text available via subscription  
Physik in unserer Zeit     Hybrid Journal  
Physik Journal     Hybrid Journal  
Plasma Physics Reports     Hybrid Journal   (Followers: 2)
Pramana     Open Access   (Followers: 9)
Preview     Hybrid Journal  
Proceedings of the National Academy of Sciences     Full-text available via subscription   (Followers: 503)
Proceedings of the National Academy of Sciences, India Section A     Hybrid Journal   (Followers: 3)
Progress in Materials Science     Hybrid Journal   (Followers: 19)
Progress in Planning     Hybrid Journal   (Followers: 1)
Progress of Theoretical and Experimental Physics     Open Access  
Quantum Electronics     Full-text available via subscription   (Followers: 2)
Quantum Measurements and Quantum Metrology     Open Access  
Quarterly Journal of Mechanics and Applied Mathematics     Hybrid Journal   (Followers: 3)
Radiation Effects and Defects in Solids     Hybrid Journal   (Followers: 1)
Radiation Measurements     Hybrid Journal   (Followers: 2)
Radiation Physics and Chemistry     Hybrid Journal   (Followers: 1)
Radiation Protection Dosimetry     Hybrid Journal   (Followers: 2)
Radiation Research     Full-text available via subscription   (Followers: 3)
Radio Science     Full-text available via subscription   (Followers: 3)
Radiological Physics and Technology     Hybrid Journal   (Followers: 1)
Reflets de la physique     Full-text available via subscription  
Reports on Mathematical Physics     Full-text available via subscription  
Reports on Progress in Physics     Full-text available via subscription   (Followers: 2)
Research & Reviews : Journal of Physics     Full-text available via subscription  
Research in Drama Education     Hybrid Journal   (Followers: 11)
Research Journal of Physics     Open Access  
Results in Physics     Open Access   (Followers: 1)
Reviews in Mathematical Physics     Hybrid Journal  
Reviews of Accelerator Science and Technology     Hybrid Journal  
Reviews of Geophysics     Full-text available via subscription   (Followers: 19)
Reviews of Modern Physics     Full-text available via subscription   (Followers: 17)
Revista Colombiana de Física     Open Access  
Revista Mexicana de Astronomía y Astrofísica     Open Access  
Revista Mexicana de Física     Open Access  
Revista mexicana de física E     Open Access  
Rheologica Acta     Hybrid Journal   (Followers: 3)
Russian Journal of Mathematical Physics     Hybrid Journal  
Russian Journal of Nondestructive Testing     Hybrid Journal   (Followers: 1)
Russian Physics Journal     Hybrid Journal  
Samuel Beckett Today/Aujourd'hui     Full-text available via subscription   (Followers: 2)
Science and Technology of Nuclear Installations     Open Access   (Followers: 1)
Science China : Physics, Mechanics & Astronomy     Full-text available via subscription   (Followers: 1)
Science Foundation in China     Full-text available via subscription   (Followers: 2)
Scientific Journal of Physical Science     Open Access  
Scientific Reports     Open Access   (Followers: 11)
Selected Topics in Applied Earth Observations and Remote Sensing, IEEE Journal of     Hybrid Journal   (Followers: 16)
Sensor Letters     Full-text available via subscription   (Followers: 1)
Sensors and Actuators A: Physical     Hybrid Journal   (Followers: 34)
Services Computing, IEEE Transactions on     Hybrid Journal   (Followers: 3)
Shock and Vibration     Hybrid Journal   (Followers: 7)
Shock Waves     Hybrid Journal   (Followers: 4)
Small     Hybrid Journal   (Followers: 9)
Software Engineering, IEEE Transactions on     Hybrid Journal   (Followers: 20)
Solid State Physics     Full-text available via subscription  

  First | 1 2 3 4 5 6 | Last

Journal Cover Nature Communications     [SJR: 5.041]   [H-I: 34]
   [44 followers]  Follow    
   Hybrid Journal Hybrid journal (It can contain Open Access articles)
   ISSN (Online) 2041-1723
   Published by Nature Publishing Group Homepage  [110 journals]
  • Dppa3 expression is critical for generation of fully reprogrammed iPS
           cells and maintenance of Dlk1-Dio3 imprinting
    • Authors: Xingbo Xu, Lukasz Smorag, Toshinobu Nakamura, Tohru Kimura, Ralf Dressel, Antje Fitzner, Xiaoying Tan, Matthias Linke, Ulrich Zechner, Wolfgang Engel, D. V. Krishna Pantakani
      Abstract: Reprogramming of mouse somatic cells into iPSCs often generates pre-iPSCs, low-grade iPSCs that show abnormal Dlk1-Dio3 imprinting, and fully reprogrammed, high-grade iPSCs. Here, the authors show that germ-cell marker Dppa3 enhances reprogramming kinetics, critical for the maintenance of Dlk1-Dio3 imprinting and generation of fully reprogrammed iPSCs.
      Citation: Nature Communications
      PubDate: 2015-01-23|2015-01-23
      DOI: 10.1038/ncomms7008
  • Systems genetics identifies Sestrin 3 as a regulator of a proconvulsant
           gene network in human epileptic hippocampus
    • Authors: Michael R. Johnson, Jacques Behmoaras, Leonardo Bottolo, Michelle L. Krishnan, Katharina Pernhorst, Paola L. Meza Santoscoy, Tiziana Rossetti, Doug Speed, Prashant K. Srivastava, Marc Chadeau-Hyam, Nabil Hajji, Aleksandra Dabrowska, Maxime Rotival, Banafsheh Razzaghi, Stjepana Kovac, Klaus Wanisch, Federico W. Grillo, Anna Slaviero, Sarah R. Langley, Kirill Shkura, Paolo Roncon, Tisham De, Manuel Mattheisen, Pitt Niehusmann, Terence J. O’Brien, Slave Petrovski, Marec von Lehe, Per Hoffmann, Johan Eriksson, Alison J. Coffey, Sven Cichon, Matthew Walker, Michele Simonato, Bénédicte Danis, Manuela Mazzuferi, Patrik Foerch, Susanne Schoch, Vincenzo De Paola, Rafal M. Kaminski, Vincent T. Cunliffe, Albert J. Becker, Enrico Petretto
      Abstract: Neurological disorders such as temporal lobe epilepsy (TLE) are known to be regulated by gene networks. In this study, the authors describe a genome-wide approach that uses samples of hippocampal tissue from patients with TLE, to identify the gene Sestrin 3 ( SESN3 ) as a positive regulator of the disease.
      Citation: Nature Communications
      PubDate: 2015-01-23|2015-01-23
      DOI: 10.1038/ncomms7031
  • Evidence for a small hole pocket in the Fermi surface of underdoped
    • Authors: N. Doiron-Leyraud, S. Badoux, S. René de Cotret, S. Lepault, D. LeBoeuf, F. Laliberté, E. Hassinger, B. J. Ramshaw, D. A. Bonn, W. N. Hardy, R. Liang, J.-H.. Park, D. Vignolles, B. Vignolle, L. Taillefer, C. Proust
      Abstract: Fully mapping the Fermi surface of a compound provides a clear picture of its fundamental properties. Through thermoelectric measurements of the underdoped cuprate YBa 2 Cu 3 O y , this study shows evidence for a second Fermi pocket, consistent with charge–density–wave Fermi surface reconstruction.
      Citation: Nature Communications
      PubDate: 2015-01-23|2015-01-23
      DOI: 10.1038/ncomms7034
  • An IL-27/NFIL3 signalling axis drives Tim-3 and IL-10 expression and
           T-cell dysfunction
    • Authors: Chen Zhu, Kaori Sakuishi, Sheng Xiao, Zhiyi Sun, Sarah Zaghouani, Guangxiang Gu, Chao Wang, Dewar J. Tan, Chuan Wu, Manu Rangachari, Thomas Pertel, Hyun-Tak Jin, Rafi Ahmed, Ana C. Anderson, Vijay K. Kuchroo
      Abstract: Tim-3 is an inhibitory molecule that suppresses T-cell responses. Here the authors show that the cytokine IL-27, acting through the transcription factor NFIL3, induces Tim-3 in vivo , and that IL-27-conditioned Th1 cells have poor effector function.
      Citation: Nature Communications
      PubDate: 2015-01-23|2015-01-23
      DOI: 10.1038/ncomms7072
  • Corrigendum: Identifying signatures of photothermal current in a
           double-gated semiconducting nanotube
    • Authors: G. Buchs, S. Bagiante, G. A. Steele
      Citation: Nature Communications
      PubDate: 2015-01-23|2015-01-23
      DOI: 10.1038/ncomms6463
  • UCHL1 provides diagnostic and antimetastatic strategies due to its
           deubiquitinating effect on HIF-1α
    • Authors: Yoko Goto, Lihua Zeng, Chan Joo Yeom, Yuxi Zhu, Akiyo Morinibu, Kazumi Shinomiya, Minoru Kobayashi, Kiichi Hirota, Satoshi Itasaka, Michio Yoshimura, Keiji Tanimoto, Masae Torii, Terumasa Sowa, Toshi Menju, Makoto Sonobe, Hideaki Kakeya, Masakazu Toi, Hiroshi Date, Ester M. Hammond, Masahiro Hiraoka, Hiroshi Harada
      Abstract: When stabilized, HIF-1 can activate adaptation to hypoxia and metastasis. Here the authors show that upregulation of Ubiquitin C-terminal hydrolase-L1 in human cancers promotes metastasis and correlates with poor prognosis because of its role in opposing ubiquitin-mediated degradation of HIF-1.
      Citation: Nature Communications
      PubDate: 2015-01-23|2015-01-23
      DOI: 10.1038/ncomms7153
  • Chromatin remodelling and autocrine TNFα are required for optimal
           interleukin-6 expression in activated human neutrophils
    • Authors: Maili Zimmermann, Francisco Bianchetto Aguilera, Monica Castellucci, Marzia Rossato, Sara Costa, Claudio Lunardi, Renato Ostuni, Giampiero Girolomoni, Gioacchino Natoli, Flavia Bazzoni, Nicola Tamassia, Marco A. Cassatella
      Abstract: How IL-6 expression is regulated in human neutrophils has remained unclear. Here the authors show, using highly purified neutrophils, that TLR8 or TLR4 signalling activates latent enhancers and cooperates with autocrine TNFα to induce IL-6 transcription.
      Citation: Nature Communications
      PubDate: 2015-01-23|2015-01-23
      DOI: 10.1038/ncomms7061
  • Site- and allele-specific polycomb dysregulation in T-cell leukaemia
    • Authors: Jean-Marc Navarro, Aurore Touzart, Lydie C. Pradel, Marie Loosveld, Myriam Koubi, Romain Fenouil, Sandrine Le Noir, Muhammad Ahmad Maqbool, Ester Morgado, Claude Gregoire, Sebastien Jaeger, Emilie Mamessier, Charles Pignon, Salima Hacein-Bey-Abina, Bernard Malissen, Marta Gut, Ivo G. Gut, Hervé Dombret, Elizabeth A. Macintyre, Steven J. Howe, H. Bobby Gaspar, Adrian J. Thrasher, Norbert Ifrah, Dominique Payet-Bornet, Estelle Duprez, Jean-Christophe Andrau, Vahid Asnafi, Bertrand Nadel
      Abstract: TAL1 is frequently deregulated in T-cell acute lymphoblastic leukaemias, but the mechanism remains largely unclear. Here the authors show that microinsertions upstream of TAL1 cause its epigenetic reactivation, and that the mode of TAL1 activation correlates with prognosis.
      Citation: Nature Communications
      PubDate: 2015-01-23|2015-01-23
      DOI: 10.1038/ncomms7094
  • A number-form area in the blind
    • Authors: Sami Abboud, Shachar Maidenbaum, Stanislas Dehaene, Amir Amedi
      Abstract: The human visual cortex includes areas with preference for various object categories. Here, Abboud et al . demonstrate using visual-to-music substitution, that the congenitally blind show a similar preference for numerals in the right inferior temporal cortex as sighted individuals, despite having no visual experience.
      Citation: Nature Communications
      PubDate: 2015-01-23|2015-01-23
      DOI: 10.1038/ncomms7026
  • Predicting oculomotor behaviour from correlated populations of posterior
           parietal neurons
    • Authors: Arnulf B. A. Graf, Richard A. Andersen
      Abstract: Cortical brain signals are often studied by predicting sensory inputs and behaviours from ensembles of neurons, but the uncertainty of these predictions is poorly understood. Graf and Andersen show that the level of uncertainty is reduced when populations of cortical neurons exhibit correlated variability.
      Citation: Nature Communications
      PubDate: 2015-01-23|2015-01-23
      DOI: 10.1038/ncomms7024
  • Gene therapy restores vision in rd1 mice after removal of a confounding
           mutation in Gpr179
    • Authors: Koji M. Nishiguchi, Livia S. Carvalho, Matteo Rizzi, Kate Powell, Sophia-Martha kleine Holthaus, Selina A. Azam, Yanai Duran, Joana Ribeiro, Ulrich F. O. Luhmann, James W. B. Bainbridge, Alexander J. Smith, Robin R. Ali
      Abstract: The rd1 mouse is the most widely used model to study retinal degeneration. Here, the authors identify a wide-spread mutation in these mice that may explain the failure of previous gene therapeutic approaches and show that long-lasting restoration of vision is possible in rd1 mice without this mutation.
      Citation: Nature Communications
      PubDate: 2015-01-23|2015-01-23
      DOI: 10.1038/ncomms7006
  • Fumarate induces redox-dependent senescence by modifying glutathione
    • Authors: Liang Zheng, Simone Cardaci, Livnat Jerby, Elaine D. MacKenzie, Marco Sciacovelli, T. Isaac Johnson, Edoardo Gaude, Ayala King, Joshua D. G. Leach, RuAngelie Edrada-Ebel, Ann Hedley, Nicholas A. Morrice, Gabriela Kalna, Karen Blyth, Eytan Ruppin, Christian Frezza, Eyal Gottlieb
      Abstract: Fumarate hydratase (FH) mutations are associated with renal cancer. Here, Zheng et al . use metabolomic and analytical chemistry approaches to reveal that fumarate accumulated due to FH loss covalently modifies intracellular glutathione, leading to oxidative stress and senescence.
      Citation: Nature Communications
      PubDate: 2015-01-23|2015-01-23
      DOI: 10.1038/ncomms7001
  • Different forms of effective connectivity in primate frontotemporal
    • Authors: Christopher I. Petkov, Yukiko Kikuchi, Alice E. Milne, Mortimer Mishkin, Josef P. Rauschecker, Nikos K. Logothetis
      Abstract: Neural pathways to frontal cortex areas of the brain enable communication, but their connectivity is unclear. Petkov et al . use electrical microstimulation and brain imaging to describe different forms of hierarchical effective connectivity that exist between the primate frontal and temporal cortex.
      Citation: Nature Communications
      PubDate: 2015-01-23|2015-01-23
      DOI: 10.1038/ncomms7000
  • DNA sequencing using polymerase substrate-binding kinetics
    • Authors: Michael John Robert Previte, Chunhong Zhou, Matthew Kellinger, Rigo Pantoja, Cheng-Yao Chen, Jin Shi, BeiBei Wang, Amirali Kia, Sergey Etchin, John Vieceli, Ali Nikoomanzar, Erin Bomati, Christian Gloeckner, Mostafa Ronaghi, Molly Min He
      Abstract: Next-generation sequencing technologies vary in performance, which is often measured by metrics such as sequencing speed, accuracy and read length. Here, the authors present a new sequencing by synthesis method that monitors polymerase binding to DNA, and suggest that this method has the potential to generate longer and faster reads.
      Citation: Nature Communications
      PubDate: 2015-01-23|2015-01-23
      DOI: 10.1038/ncomms6936
  • Gd-metallofullerenol nanomaterial as non-toxic breast cancer stem
           cell-specific inhibitor
    • Authors: Ying Liu, Chunying Chen, Pengxu Qian, Xuefei Lu, Baoyun Sun, Xiao Zhang, Liming Wang, Xingfa Gao, Han Li, Zhiyun Chen, Jinglong Tang, Weijie Zhang, Jinquan Dong, Ru Bai, Peter E. Lobie, Qingfa Wu, Suling Liu, Huafeng Zhang, Feng Zhao, Max S. Wicha, Tao Zhu, Yuliang Zhao
      Abstract: A metallofullerenol nanomaterial, Gd@C 82 (OH) 22 , was shown to inhibit growth of several solid cancers in preclinical models and yet exhibit low toxicity. Herein the authors show that Gd@C 82 (OH) 22 functions as an inhibitor of breast cancer stem cell function via blocking TGF-β and HIF-1α signalling, while sparing normal tissue.
      Citation: Nature Communications
      PubDate: 2015-01-23|2015-01-23
      DOI: 10.1038/ncomms6988
  • Autophagy enhances NFκB activity in specific tissue macrophages by
           sequestering A20 to boost antifungal immunity
    • Authors: Masashi Kanayama, Makoto Inoue, Keiko Danzaki, Gianna Hammer, You-Wen He, Mari L. Shinohara
      Abstract: Immune activation must be carefully tuned to respond to infection and restrained to prevent tissue damage. Here the authors show that autophagy has a role in the immune response to Candida albicans , activating NFκB in macrophages by sequestering the NFκB inhibitor A20.
      PubDate: 2015-01-22|2015-01-22
      DOI: 10.1038/ncomms6779
  • Ferroelectrically driven spatial carrier density modulation in graphene
    • Authors: Christoph Baeumer, Diomedes Saldana-Greco, John Mark P. Martirez, Andrew M. Rappe, Moonsub Shim, Lane W. Martin
      Abstract: The non-volatile modulation of charge carriers in graphene could be useful for future electronic devices. Here, the authors demonstrate that fields arising from ferroelectric polarization in periodically poled LiNbO 3 substrates can lead to a carrier modulation in adjacent graphene films.
      PubDate: 2015-01-22|2015-01-22
      DOI: 10.1038/ncomms7136
  • Organization of the mitochondrial translation machinery studied in situ by
           cryoelectron tomography
    • Authors: Stefan Pfeffer, Michael W. Woellhaf, Johannes M. Herrmann, Friedrich Förster
      Abstract: While the cytosolic translation machinery is well characterized, the mitochondrial translation system remains largely elusive. Using cryo-electron tomography, Pfeffer et al . describe the ordered organization of mitochondrial polysomes in which each ribosome is tethered to the inner membrane by two defined contacts on the large subunit in situ .
      PubDate: 2015-01-22|2015-01-22
      DOI: 10.1038/ncomms7019
  • Climate variation explains a third of global crop yield variability
    • Authors: Deepak K. Ray, James S. Gerber, Graham K. MacDonald, Paul C. West
      Abstract: Agricultural crops are closely linked to the climate in which they grow, but the extent to which variability in weather influences yield is not well characterized. Here, Ray et al . find that climatic variation explains around a third of the variation in global crop yields, with important regional variations.
      PubDate: 2015-01-22|2015-01-22
      DOI: 10.1038/ncomms6989
  • MazF ribonucleases promote Mycobacterium tuberculosis drug tolerance and
           virulence in guinea pigs
    • Authors: Prabhakar Tiwari, Garima Arora, Mamta Singh, Saqib Kidwai, Om Prakash Narayan, Ramandeep Singh
      Abstract: Mycobacterium tuberculosis possesses several toxin–antitoxin systems of the MazEF family. Here, Tiwari et al . show that these systems contribute to stress adaptation, antibiotic tolerance and virulence.
      PubDate: 2015-01-22|2015-01-22
      DOI: 10.1038/ncomms7059
  • Mutual information reveals multiple structural relaxation mechanisms in a
           model glass former
    • Authors: Andrew J. Dunleavy, Karoline Wiesner, Ryoichi Yamamoto, C. Patrick Royall
      Abstract: One mystery of glass transition from supercooled liquid is the lack of apparent change in structure, which is in contrast to a large change in dynamics. Here Dunleavy et al . provide a possible solution to this discrepancy by simulating dynamic correlation using a mutual information approach.
      PubDate: 2015-01-22|2015-01-22
      DOI: 10.1038/ncomms7089
  • Evidence for an oxygen evolving iron–oxo–cerium intermediate
           in iron-catalysed water oxidation
    • Authors: Zoel Codolà, Laura Gómez, Scott T. Kleespies, Lawrence Que Jr, Miquel Costas, Julio Lloret-Fillol
      Abstract: Non-haeme iron complexes are known to be competent catalysts for chemically driven water oxidation. Here, the authors provide evidence for the formation of an inner-sphere iron(IV)- oxygen-cerium(IV) intermediate that may provide mechanistic insight into the naturally occurring oxygen evolving complex.
      PubDate: 2015-01-22|2015-01-22
      DOI: 10.1038/ncomms6865
  • Whole-exome sequencing reveals the mutational spectrum of testicular germ
           cell tumours
    • Authors: Kevin Litchfield, Brenda Summersgill, Shawn Yost, Razvan Sultana, Karim Labreche, Darshna Dudakia, Anthony Renwick, Sheila Seal, Reem Al-Saadi, Peter Broderick, Nicholas C. Turner, Richard S. Houlston, Robert Huddart, Janet Shipley, Clare Turnbull
      Abstract: Testicular germ cell tumour (TGCT) is the most common cancer in young men. Here, the authors sequence the whole exomes of 42 TGCTs, and characterize the mutational profile of this tumour type.
      PubDate: 2015-01-22|2015-01-22
      DOI: 10.1038/ncomms6973
  • Tropical Atlantic temperature seasonality at the end of the last
    • Authors: Thomas Felis, Cyril Giry, Denis Scholz, Gerrit Lohmann, Madlene Pfeiffer, Jürgen Pätzold, Martin Kölling, Sander R. Scheffers
      Abstract: The last interglacial has been suggested as a test bed for models developed for future climate prediction, yet many climatic parameters remain unknown. Here, the authors present a precisely dated fossil coral and show that temperature seasonality in the southern Caribbean Sea 118 ka was similar to today.
      PubDate: 2015-01-22|2015-01-22
      DOI: 10.1038/ncomms7159
  • A proteomic approach reveals integrin activation state-dependent control
           of microtubule cortical targeting
    • Authors: Adam Byron, Janet A. Askari, Jonathan D. Humphries, Guillaume Jacquemet, Ewa J. Koper, Stacey Warwood, Colin K. Choi, Matthew J. Stroud, Christopher S. Chen, David Knight, Martin J. Humphries
      Abstract: Integrins are activated by many extracellular cues and respond by assembling diverse signalling complexes. Byron et al. use activation state-specific antibodies to proteomically characterize these complexes, and provide insight into integrin-dependent microtubule stabilization.
      PubDate: 2015-01-22|2015-01-22
      DOI: 10.1038/ncomms7135
  • Osmotic pressure induced tensile forces in tendon collagen
    • Authors: Admir Masic, Luca Bertinetti, Roman Schuetz, Shu-Wei Chang, Till Hartmut Metzger, Markus J. Buehler, Peter Fratzl
      Abstract: Water is an important component of collagen in tendons, bone and extracellular matrix, but its role in the mechanical function of protein is poorly understood. Here, the authors study the effects of osmotic pressure on contraction in collagen, suggesting that collagen could function as a mechanical actuator.
      PubDate: 2015-01-22|2015-01-22
      DOI: 10.1038/ncomms6942
  • Structural analysis of herpes simplex virus by optical super-resolution
    • Authors: Romain F. Laine, Anna Albecka, Sebastian van de Linde, Eric J. Rees, Colin M. Crump, Clemens F. Kaminski
      Abstract: Herpes simplex virus type-1 (HSV-1) is a widespread human pathogen, the structure of which is not yet fully characterized. Here, the authors apply d STORM super-resolution microscopy in combination with advanced data analysis tools to locate the position of four key protein layers in HSV-1 with unprecedented precision.
      PubDate: 2015-01-22|2015-01-22
      DOI: 10.1038/ncomms6980
  • Proteasome assembly from 15S precursors involves major conformational
           changes and recycling of the Pba1–Pba2 chaperone
    • Authors: Malte Kock, Maria M. Nunes, Matthias Hemann, Sebastian Kube, R. Jürgen Dohmen, Franz Herzog, Paula C. Ramos, Petra Wendler
      Abstract: The barrel-shaped 20S proteasome core particle assembles via 15S intermediates through the action of Ump1 and Pba1–Pba2 chaperones. Using structural approaches, Kock et al . reveal conformational changes occurring upon formation of the nascent 20S particle leading to ejection of Pba1–Pba2.
      PubDate: 2015-01-22|2015-01-22
      DOI: 10.1038/ncomms7123
  • PD-L1hi B cells are critical regulators of humoral immunity
    • Authors: Adnan R. Khan, Emily Hams, Achilleas Floudas, Tim Sparwasser, Casey T. Weaver, Padraic G. Fallon
      Abstract: Follicular helper T cells promote antibody production by B cells, and regulatory B cells, in turn, can restrain T cell activation. Here, Khan et al . show that PD-L1 plays a critical role in regulatory B cell function, curbing excessive immune responses by engaging the PD-1 receptor on follicular helper T cells.
      PubDate: 2015-01-22|2015-01-22
      DOI: 10.1038/ncomms6997
  • Mechanics of epithelial closure over non-adherent environments
    • Authors: Sri Ram Krishna Vedula, Grégoire Peyret, Ibrahim Cheddadi, Tianchi Chen, Agustí Brugués, Hiroaki Hirata, Horacio Lopez-Menendez, Yusuke Toyama, Luís Neves de Almeida, Xavier Trepat, Chwee Teck Lim, Benoit Ladoux
      Abstract: Closure of epithelial gaps such as wounds is thought to involve contraction of an actomyosin ‘purse-string’. By creating non-adherent gaps to exclude contributions of adhesive protrusion, the authors find that large-scale tension, more than purse-string contraction, mediates closure.
      PubDate: 2015-01-22|2015-01-22
      DOI: 10.1038/ncomms7111
  • Multi-channel electronic and vibrational dynamics in polyatomic resonant
           high-order harmonic generation
    • Authors: A. Ferré, A. E. Boguslavskiy, M. Dagan, V. Blanchet, B. D. Bruner, F. Burgy, A. Camper, D. Descamps, B. Fabre, N. Fedorov, J. Gaudin, G. Geoffroy, J. Mikosch, S. Patchkovskii, S. Petit, T. Ruchon, H. Soifer, D. Staedter, I. Wilkinson, A. Stolow, N. Dudovich, Y. Mairesse
      Abstract: Strong-field ionization in molecules is more complex than in atoms with multiple channel dynamics and a coherent superposition of electronic states. Here, Ferré et al . develop multi-modal spectroscopy to measure those dynamics and reveal a resonant to non-resonant high-harmonic generation transition.
      PubDate: 2015-01-22|2015-01-22
      DOI: 10.1038/ncomms6952
  • Structure and boosting activity of a starch-degrading lytic polysaccharide
    • Authors: Leila Lo Leggio, Thomas J. Simmons, Jens-Christian N. Poulsen, Kristian E. H. Frandsen, Glyn R. Hemsworth, Mary A. Stringer, Pernille von Freiesleben, Morten Tovborg, Katja S. Johansen, Leonardo De Maria, Paul V. Harris, Chee-Leong Soong, Paul Dupree, Theodora Tryfona, Nicolas Lenfant, Bernard Henrissat, Gideon J. Davies, Paul H. Walton
      Abstract: Lytic polysaccharide monooxygenases (LPMOs) are industrially important enzymes that oxidatively deconstruct polysaccharides. Here, Lo Leggio et al . report the activity, spectroscopy and three-dimensional structure of a LPMO of the new CAZy AA13 family active on recalcitrant-retrograded starch.
      PubDate: 2015-01-22|2015-01-22
      DOI: 10.1038/ncomms6961
  • The epigenetic modifier EZH2 controls melanoma growth and metastasis
           through silencing of distinct tumour suppressors
    • Authors: Daniel Zingg, Julien Debbache, Simon M. Schaefer, Eylul Tuncer, Sandra C. Frommel, Phil Cheng, Natalia Arenas-Ramirez, Jessica Haeusel, Yudong Zhang, Mario Bonalli, Michael T. McCabe, Caretha L. Creasy, Mitchell P. Levesque, Onur Boyman, Raffaella Santoro, Olga Shakhova, Reinhard Dummer, Lukas Sommer
      Abstract: The epigenetic modifier EZH2 is highly expressed in melanoma but its role in cancer initiation and progression is still unclear. Here the authors use mouse models and human cell lines to show that EZH2 has an essential role in melanoma progression and metastasis, thus highlighting its potential as a therapeutic target.
      PubDate: 2015-01-22|2015-01-22
      DOI: 10.1038/ncomms7051
  • Chromatin decompaction by the nucleosomal binding protein HMGN5 impairs
           nuclear sturdiness
    • Authors: Takashi Furusawa, Mark Rochman, Leila Taher, Emilios K. Dimitriadis, Kunio Nagashima, Stasia Anderson, Michael Bustin
      Abstract: Whether heterochromatin affects the physical properties of the nucleus is not known. Here, Furusawa et al . show that chromatin decompaction decreases the sturdiness of the nucleus in cultured cells and leads to lamina disruption and cardiac abnormalities in adult mice, suggesting a structural, non-genetic function for heterochromatin.
      PubDate: 2015-01-22|2015-01-22
      DOI: 10.1038/ncomms7138
  • Genome-wide meta-analysis in alopecia areata resolves HLA associations and
           reveals two new susceptibility loci
    • Authors: Regina C. Betz, Lynn Petukhova, Stephan Ripke, Hailiang Huang, Androniki Menelaou, Silke Redler, Tim Becker, Stefanie Heilmann, Tarek Yamany, Madeliene Duvic, Maria Hordinsky, David Norris, Vera H. Price, Julian Mackay-Wiggan, Annemieke de Jong, Gina M. DeStefano, Susanne Moebus, Markus Böhm, Ulrike Blume-Peytavi, Hans Wolff, Gerhard Lutz, Roland Kruse, Li Bian, Christopher I. Amos, Annette Lee, Peter K. Gregersen, Bettina Blaumeiser, David Altshuler, Raphael Clynes, Paul I. W. de Bakker, Markus M. Nöthen, Mark J. Daly, Angela M. Christiano
      Abstract: Alopecia areata (AA) is a common autoimmune disease with a known genetic component. Here, the authors analyse 3,253 AA patients and 7,543 healthy controls, and identify two new risk loci and disrupted immune response pathways associated with the disease.
      PubDate: 2015-01-22|2015-01-22
      DOI: 10.1038/ncomms6966
  • Massive parallel sequencing uncovers actionable FGFR2–PPHLN1 fusion
           and ARAF mutations in intrahepatic cholangiocarcinoma
    • Authors: Daniela Sia, Bojan Losic, Agrin Moeini, Laia Cabellos, Ke Hao, Kate Revill, Dennis Bonal, Oriana Miltiadous, Zhongyang Zhang, Yujin Hoshida, Helena Cornella, Mireia Castillo-Martin, Roser Pinyol, Yumi Kasai, Sasan Roayaie, Swan N. Thung, Josep Fuster, Myron E. Schwartz, Samuel Waxman, Carlos Cordon-Cardo, Eric Schadt, Vincenzo Mazzaferro, Josep M. Llovet
      Abstract: Intrahepatic cholangiocarcinoma is an aggressive cancer of the bile duct with few treatment options and a below 10% five-year survival rate. Here Sia et al . show a novel FGFR2–PPHLN1 fusion and ARAF mutations that may represent future potential therapeutic targets.
      PubDate: 2015-01-22|2015-01-22
      DOI: 10.1038/ncomms7087
  • Interfering with stem cell-specific gatekeeper functions controls tumour
           initiation and malignant progression of skin tumours
    • Authors: Monika Petersson, Karen Reuter, Heike Brylka, Andreas Kraus, Peter Schettina, Catherin Niemann
      Abstract: The presence of multiple stem and progenitor cells in the skin has a major impact on the formation of different epidermal tumours. Here the authors identify bulge stem cells as the cells of origin of sebaceous tumours through genetic lineage tracing and molecular studies in a mouse model.
      PubDate: 2015-01-22|2015-01-22
      DOI: 10.1038/ncomms6874
  • A minimal physical model captures the shapes of crawling cells
    • Authors: E. Tjhung, A. Tiribocchi, D. Marenduzzo, M. E. Cates
      Abstract: How living cells move around is crucial for the understanding of their biological functions. Here, Tjhung et al . reproduce cellular motility via a minimal physical model, whereby a cell in three-dimensions is represented as a droplet of active polar fluid constrained by interfacial tension.
      PubDate: 2015-01-21|2015-01-21
      DOI: 10.1038/ncomms6420
  • An ultra-low-input native ChIP-seq protocol for genome-wide profiling of
           rare cell populations
    • Authors: Julie Brind’Amour, Sheng Liu, Matthew Hudson, Carol Chen, Mohammad M. Karimi, Matthew C. Lorincz
      Abstract: Standard ChIP-seq protocols require large numbers of cells for high-quality datasets, limiting the application of this technique on rare cell types. Here, Brind’Amour et al . introduce an ultra-low-input ChIP-seq protocol to generate maps of covalent histone marks from as few as 1,000 cells.
      PubDate: 2015-01-21|2015-01-21
      DOI: 10.1038/ncomms7033
  • Self-assembly and electrostriction of arrays and chains of hopfion
           particles in chiral liquid crystals
    • Authors: Paul J. Ackerman, Jao van de Lagemaat, Ivan I. Smalyukh
      Abstract: Topological defects can be spontaneously generated to thermodynamically stabilize a variety of peculiar condensed matter phases for technological applications. Here, Ackerman et al . show electrically controllable self-assembly of knotted defects into periodic arrays in chiral liquid crystals.
      PubDate: 2015-01-21|2015-01-21
      DOI: 10.1038/ncomms7012
  • Uncovering the spatial structure of mobility networks
    • Authors: Thomas Louail, Maxime Lenormand, Miguel Picornell, Oliva García Cantú, Ricardo Herranz, Enrique Frias-Martinez, José J. Ramasco, Marc Barthelemy
      Abstract: The availability of pervasive data has opened up possibilities for quantitative approaches to many phenomena, but extracting useful information from huge datasets is difficult. Here, Louail et al . propose a method to extract a coarse-grained signature of large weighted networks and apply it to mobility networks.
      PubDate: 2015-01-21|2015-01-21
      DOI: 10.1038/ncomms7007
  • Upward electrical discharges observed above Tropical Depression Dorian
    • Authors: Ningyu Liu, Nicholas Spiva, Joseph R. Dwyer, Hamid K. Rassoul, Dwayne Free, Steven A. Cummer
      Abstract: Upward electrical discharges from thunderstorms were discovered recently, and only a very limited set of observations exist because they are rare and unpredictable. Here, the authors present recordings of different types of the discharge above a storm, which contradict current theories of their origins.
      PubDate: 2015-01-21|2015-01-21
      DOI: 10.1038/ncomms6995
  • Sequencing of first-strand cDNA library reveals full-length transcriptomes
    • Authors: Saurabh Agarwal, Todd S. Macfarlan, Maureen A. Sartor, Shigeki Iwase
      Abstract: Strand-specific RNA-seq (ssRNA-seq) data often lack information on 5′ and 3′ ends of transcripts. Here the authors present a novel method for ssRNA-seq that enables the simultaneous profiling of gene expression, TSSs and polyadenylation sites at near-base resolution with a single library.
      PubDate: 2015-01-21|2015-01-21
      DOI: 10.1038/ncomms7002
  • Numerical chromosomal instability mediates susceptibility to radiation
    • Authors: Samuel F. Bakhoum, Lilian Kabeche, Matthew D. Wood, Christopher D. Laucius, Dian Qu, Ashley M. Laughney, Gloria E. Reynolds, Raymond J. Louie, Joanna Phillips, Denise A. Chan, Bassem I. Zaki, John P. Murnane, Claudia Petritsch, Duane A. Compton
      Abstract: Ionizing radiations (IRs) cause widespread genomic damage and can, through unknown mechanisms, lead to changes in chromosome numbers by perturbing the cells undergoing mitosis. Here, the authors investigate the potential mechanism behind the increased susceptibility of mitotic cells to IRs.
      PubDate: 2015-01-21|2015-01-21
      DOI: 10.1038/ncomms6990
  • Sub-50-nm self-assembled nanotextures for enhanced broadband
           antireflection in silicon solar cells
    • Authors: Atikur Rahman, Ahsan Ashraf, Huolin Xin, Xiao Tong, Peter Sutter, Matthew D. Eisaman, Charles T. Black
      Abstract: Broadband light antireflection materials have numerous applications as highly transparent window, for broadband applications thin-film multilayers have been considered. Here, Rahman et al . demonstrate broadband antireflection enhancement in silicon solar cells using a self-assembled, nanostructured copolymer.
      PubDate: 2015-01-21|2015-01-21
      DOI: 10.1038/ncomms6963
  • An iron-based green approach to 1-h production of single-layer graphene
    • Authors: Li Peng, Zhen Xu, Zheng Liu, Yangyang Wei, Haiyan Sun, Zheng Li, Xiaoli Zhao, Chao Gao
      Abstract: Oxidants currently used in the preparation of graphene oxide (GO) require long reaction times, relatively high temperatures and costly waste treatment. Here, the authors propose the use of a strong green oxidant, K2FeO4, establishing a fast, safe, toxicity-free route to GO production.
      PubDate: 2015-01-21|2015-01-21
      DOI: 10.1038/ncomms6716
  • IL-10 engages macrophages to shift Th17 cytokine dependency and
           pathogenicity during T-cell-mediated colitis
    • Authors: Bofeng Li, Prajwal Gurung, R. K. Subbarao Malireddi, Peter Vogel, Thirumala-Devi Kanneganti, Terrence L. Geiger
      Abstract: The pro-inflammatory cytokine IL-1ß promotes the accumulation of pathologic Th17 lymphocytes that contribute to colitis. Here the authors show that the critical role of IL-10 in colitis suppression can be explained by its inhibition of IL-1ß production in macrophages.
      PubDate: 2015-01-21|2015-01-21
      DOI: 10.1038/ncomms7131
  • Imperceptible magnetoelectronics
    • Authors: Michael Melzer, Martin Kaltenbrunner, Denys Makarov, Dmitriy Karnaushenko, Daniil Karnaushenko, Tsuyoshi Sekitani, Takao Someya, Oliver G. Schmidt
      Abstract: Birds and many other animals can sense the Earth’s magnetic field, but not human beings. Here, Melzer et al . develop a type of artificial skin based on giant magnetoresistive sensor foils with micrometre thickness, which can be stretched up to >250% without sacrifices in device performance.
      PubDate: 2015-01-21|2015-01-21
      DOI: 10.1038/ncomms7080
  • The adhesion G protein-coupled receptor GPR56 is a cell-autonomous
           regulator of oligodendrocyte development
    • Authors: Stefanie Giera, Yiyu Deng, Rong Luo, Sarah D. Ackerman, Amit Mogha, Kelly R. Monk, Yanqin Ying, Sung-Jin Jeong, Manabu Makinodan, Allison R. Bialas, Bernard S. Chang, Beth Stevens, Gabriel Corfas, Xianhua Piao
      Abstract: Mutations in GPR56, a member of the adhesion G protein-coupled receptor family, cause a specific human brain malformation and myelination defects but the cellular causes remain unclear. Here the authors show that loss of Gpr56 in mice leads to decreased oligodendrocyte precursor cell proliferation and diminished levels of active RhoA.
      PubDate: 2015-01-21|2015-01-21
      DOI: 10.1038/ncomms7121
  • Regulation of T-cell activation and migration by the kinase TBK1 during
    • Authors: Jiayi Yu, Xiaofei Zhou, Mikyoung Chang, Mako Nakaya, Jae-Hoon Chang, Yichuan Xiao, J. William Lindsey, Stephanie Dorta-Estremera, Wei Cao, Anna Zal, Tomasz Zal, Shao-Cong Sun
      Abstract: T cells that are activated by self-antigens in the periphery can migrate into the brain causing neuroinflammatory disease. Here the authors show that TBK1 is necessary for activated T-cell egress from the lymph node, and blocking TBK1 ameliorates autoimmunity in a mouse model of multiple sclerosis.
      PubDate: 2015-01-21|2015-01-21
      DOI: 10.1038/ncomms7074
  • Interplay of weak interactions in the atom-by-atom condensation of xenon
           within quantum boxes
    • Authors: Sylwia Nowakowska, Aneliia Wäckerlin, Shigeki Kawai, Toni Ivas, Jan Nowakowski, Shadi Fatayer, Christian Wäckerlin, Thomas Nijs, Ernst Meyer, Jonas Björk, Meike Stöhr, Lutz H. Gade, Thomas A. Jung
      Abstract: Condensation in the regime of weakly interactions is of fundamental importance. Here, the authors study the condensation process one atom at a time, showing the forces driving the behaviour of xenon atoms as they condense into aggregate structures in nanoscale pores.
      PubDate: 2015-01-21|2015-01-21
      DOI: 10.1038/ncomms7071
  • The phase diagram of electron-doped La2−xCexCuO4−δ
    • Authors: H. Saadaoui, Z. Salman, H. Luetkens, T. Prokscha, A. Suter, W. A. MacFarlane, Y. Jiang, K. Jin, R. L. Greene, E. Morenzoni, R. F. Kiefl
      Abstract: The relationship between superconductivity and antiferromagnetism is an unresolved question in electron-doped high- T c superconductors. Saadaoui et al . perform low-energy muon spin relaxation measurements to study the phase diagram of La 2−x Ce x CuO 4−δ at the magnetic-superconducting transition region.
      PubDate: 2015-01-21|2015-01-21
      DOI: 10.1038/ncomms7041
  • The 40-residue insertion in Vibrio cholerae FadR facilitates binding
           of an additional fatty acyl-CoA ligand
    • Authors: Wei Shi, Gabriela Kovacikova, Wei Lin, Ronald K. Taylor, Karen Skorupski, F. Jon Kull
      Abstract: FadR is a regulator of fatty acid metabolism in bacteria, and contains a binding site for acyl-CoA. Here, Shi et al . present a structure of V. cholerae FadR and show that a unique C-terminal extension comprises a second acyl-CoA binding site, perhaps rendering V. cholerae FadR a more efficient regulator.
      PubDate: 2015-01-21|2015-01-21
      DOI: 10.1038/ncomms7032
  • Discovery of optimal zeolites for challenging separations and chemical
           transformations using predictive materials modeling
    • Authors: Peng Bai, Mi Young Jeon, Limin Ren, Chris Knight, Michael W. Deem, Michael Tsapatsis, J. Ilja Siepmann
      Abstract: Zeolites are industrially important materials, functioning as separation media and catalyst supports. Here, the authors use a large-scale, multi-step computational screening process to identify promising zeolites for challenging separations, namely ethanol purification and alkane adsorption.
      PubDate: 2015-01-21|2015-01-21
      DOI: 10.1038/ncomms6912
  • Northern-hemispheric differential warming is the key to understanding the
           discrepancies in the projected Sahel rainfall
    • Authors: Jong-Yeon Park, Jürgen Bader, Daniela Matei
      Abstract: Rainfall in the Sahel region has a decadal variability related to tropical sea-surface temperatures; however, models disagree regarding future changes in rainfall. Here the authors suggest that differential warming in the northern hemisphere is key to understanding this discrepancy.
      PubDate: 2015-01-21|2015-01-21
      DOI: 10.1038/ncomms6985
  • The adhesion GPCR Gpr56 regulates oligodendrocyte development via
           interactions with Gα12/13 and RhoA
    • Authors: Sarah D. Ackerman, Cynthia Garcia, Xianhua Piao, David H. Gutmann, Kelly R. Monk
      Abstract: The adhesion class of G protein-coupled receptors (aGPCRs) is essential for peripheral nervous system myelination, but functions in central nervous system myelination are less understood. Here the authors show that the aGPCR Gpr56 plays a role in the development of myelinating oligodendrocytes and that this function is mediated by Gα12/13 proteins and Rho activation.
      PubDate: 2015-01-21|2015-01-21
      DOI: 10.1038/ncomms7122
  • Corrigendum: The adipokine Retnla modulates cholesterol homeostasis in
           hyperlipidemic mice
    • Authors: Mi-Ran Lee, Chae-ji Lim, You-Han Lee, Jong-Gil Park, Seong Keun Sonn, Mi-Ni Lee, In-Hyuk Jung, Se-Jin Jeong, Sejin Jeon, Myoungsook Lee, Ki Sook Oh, Young Yang, Jae Bum Kim, Hueng-Sik Choi, Woojin Jeong, Tae-Sook Jeong, Won Kee Yoon, Hyoung Chin Kim, Jae-Hoon Choi, Goo Taeg Oh
      PubDate: 2015-01-21|2015-01-21
      DOI: 10.1038/ncomms7076
  • Selecting core-hole localization or delocalization in CS2 by
           photofragmentation dynamics
    • Authors: R. Guillemin, P. Decleva, M. Stener, C. Bomme, T. Marin, L. Journel, T. Marchenko, R. K. Kushawaha, K. Jänkälä, N. Trcera, K. P. Bowen, D. W. Lindle, M. N. Piancastelli, M. Simon
      Abstract: Molecular core levels are localized around a single atomic site, but for indistinguishable atoms, photoionised core-holes can either be seen as localized or delocalized. Using a prototypical symmetric system, CS 2 , Guillemin et al . show that these states can be disentangled by fragmentation dynamics.
      PubDate: 2015-01-21|2015-01-21
      DOI: 10.1038/ncomms7166
  • Synthesis of large single-crystal hexagonal boron nitride grains on
           Cu–Ni alloy
    • Authors: Guangyuan Lu, Tianru Wu, Qinghong Yuan, Huishan Wang, Haomin Wang, Feng Ding, Xiaoming Xie, Mianheng Jiang
      Abstract: High nucleation density has thus far limited the quality and grain size of CVD-grown hexagonal boron nitride. Here, by optimizing the Ni ratio in Cu–Ni substrates, the authors successfully reduce nucleation density and report single-crystal hexagonal boron nitride grains up to 7500 μm 2 .
      PubDate: 2015-01-21|2015-01-21
      DOI: 10.1038/ncomms7160
  • Internalization and vacuolar targeting of the brassinosteroid hormone
           receptor BRI1 are regulated by ubiquitination
    • Authors: Sara Martins, Esther M. N. Dohmann, Anne Cayrel, Alexander Johnson, Wolfgang Fischer, Florence Pojer, Béatrice Satiat-Jeunemaître, Yvon Jaillais, Joanne Chory, Niko Geldner, Grégory Vert
      Abstract: Ubiquitination of cargo proteins regulates endocytosis in yeast and mammalian cells, however the extent to which this applies to plants is less clear. Martins et al . show that both internalization and vacuolar targetting of the Arabidopsis brassinosteroid receptor BRI1 are regulated by ubiquitination.
      PubDate: 2015-01-21|2015-01-21
      DOI: 10.1038/ncomms7151
  • Interaction between emotional state and learning underlies mood
    • Authors: Eran Eldar, Yael Niv
      Abstract: Whether emotional state affects the perception of outcomes, and the possible consequences of this interaction remain unclear. Here the authors use behavioural tests and brain imaging to study the bidirectional interaction between emotional state and learning in humans and find that this interaction may play a role in mood instability.
      PubDate: 2015-01-21|2015-01-21
      DOI: 10.1038/ncomms7149
  • Whole-exome sequencing identifies somatic ATRX mutations in
           pheochromocytomas and paragangliomas
    • Authors: Lauren Fishbein, Sanika Khare, Bradley Wubbenhorst, Daniel DeSloover, Kurt D’Andrea, Shana Merrill, Nam Woo Cho, Roger A. Greenberg, Tobias Else, Kathleen Montone, Virginia LiVolsi, Douglas Fraker, Robert Daber, Debbie L. Cohen, Katherine L. Nathanson
      Abstract: Pheochromocytomas and paragangliomas (PCC/PGL) are tumours of the autonomic nervous system. Here, the authors identify ATRX mutations in PCC/PGL and suggest that ATRX loss is important for tumorigenesis in a subset of PCC/PGL.
      PubDate: 2015-01-21|2015-01-21
      DOI: 10.1038/ncomms7140
  • Intracellular CD24 disrupts the ARF–NPM interaction and enables
           mutational and viral oncogene-mediated p53 inactivation
    • Authors: Lizhong Wang, Runhua Liu, Peiying Ye, Chunshu Wong, Guo-Yun Chen, Penghui Zhou, Kaoru Sakabe, Xincheng Zheng, Wei Wu, Peng Zhang, Taijiao Jiang, Michael F. Bassetti, Sandro Jube, Yi Sun, Yanping Zhang, Pan Zheng, Yang Liu
      Abstract: P53 is a tumour suppressor that is frequently mutated or downregulated in cancer. Here, Wang et al . show that CD24, a molecule frequently overexpressed in cancer, promotes p53 degradation by disrupting a regulatory ARF–MDM2 interaction, and silencing CD24 prevents the downregulation of p53.
      PubDate: 2015-01-20|2015-01-20
      DOI: 10.1038/ncomms6909
  • Femtosecond all-optical synchronization of an X-ray free-electron laser
    • Authors: S. Schulz, I. Grguraš, C. Behrens, H. Bromberger, J. T. Costello, M. K. Czwalinna, M. Felber, M. C. Hoffmann, M. Ilchen, H. Y. Liu, T. Mazza, M. Meyer, S. Pfeiffer, P. Prędki, S. Schefer, C. Schmidt, U. Wegner, H. Schlarb, A. L. Cavalieri
      Abstract: Few-femtosecond synchronization at free-electron lasers is key for nearly all experimental applications, stable operation and future light source development. Here, Schulz et al . demonstrate all-optical synchronization of the soft X-ray FEL FLASH to better than 30 fs and illustrate a pathway to sub-10 fs.
      PubDate: 2015-01-20|2015-01-20
      DOI: 10.1038/ncomms6938
  • Using carbon dioxide as a building block in organic synthesis
    • Authors: Qiang Liu, Lipeng Wu, Ralf Jackstell, Matthias Beller
      Abstract: Carbon dioxide is an abundant and easily available source of carbon, produced as a waste product in large quantities worldwide. Here, the authors review recent work on activating and reacting carbon dioxide for use as a building block in organic synthesis.
      PubDate: 2015-01-20|2015-01-20
      DOI: 10.1038/ncomms6933
  • Total synthesis of periploside A, a unique pregnane hexasaccharide with
           potent immunosuppressive effects
    • Authors: Xiaheng Zhang, Yu Zhou, Jianping Zuo, Biao Yu
      Abstract: Periploside A is a natural pregnane glycoside with promising immunosuppressive properties, but the presence of a seven-membered formyl acetal bridged orthoester makes it difficult to chemically synthesize. Here, the authors present a 76-step total synthesis of periploside A.
      PubDate: 2015-01-20|2015-01-20
      DOI: 10.1038/ncomms6879
  • DNase II-dependent DNA digestion is required for DNA sensing by TLR9
    • Authors: Mei Po Chan, Masahiro Onji, Ryutaro Fukui, Kohki Kawane, Takuma Shibata, Shin-ichiroh Saitoh, Umeharu Ohto, Toshiyuki Shimizu, Glen N. Barber, Kensuke Miyake
      Abstract: Discrimination between self and microbial DNA by innate receptors such as TLR9 relies on intracellular compartmentalization to increase specificity. Chan et al . show that activation of TLR9 by DNA ligands requires their processing by endolysosomal DNase II, restricting TLR9 activation to this organelle.
      PubDate: 2015-01-20|2015-01-20
      DOI: 10.1038/ncomms6853
  • ANKS6 is the critical activator of NEK8 kinase in embryonic situs
           determination and organ patterning
    • Authors: Peter G. Czarnecki, George C. Gabriel, Danielle K. Manning, Mikhail Sergeev, Kristi Lemke, Nikolai T. Klena, Xiaoqin Liu, Yu Chen, You Li, Jovenal T. San Agustin, Maija K. Garnaas, Richard J. Francis, Kimimasa Tobita, Wolfram Goessling, Gregory J. Pazour, Cecilia W. Lo, David R. Beier, Jagesh V. Shah
      Abstract: Protein kinase NEK8 is important for cilliary function, but the mechanism by which it acts is unknown. Czarnecki et al . identify the cilliary protein ANKS6 as a target and crucial activator of NEK8 and describe the importance of this protein interaction in embryonic development and organogenesis.
      PubDate: 2015-01-20|2015-01-20
      DOI: 10.1038/ncomms7023
  • Phase evolution in single-crystalline LiFePO4 followed by in situ scanning
           X-ray microscopy of a micrometre-sized battery
    • Authors: Nils Ohmer, Bernhard Fenk, Dominik Samuelis, Chia-Chin Chen, Joachim Maier, Markus Weigand, Eberhard Goering, Gisela Schütz
      Abstract: The phase transformation of LiFePO 4 /FePO 4 is an intriguing problem in lithium-ion battery research. Here, the authors use scanning transmission X-ray microscopy to reveal in-situ phase evolution of LiFePO 4 /FePO 4 in a micrometer scale battery cell with well characterised single-crystalline electrodes.
      PubDate: 2015-01-20|2015-01-20
      DOI: 10.1038/ncomms7045
  • A molecular pathway for CO2 response in Arabidopsis guard cells
    • Authors: Wang Tian, Congcong Hou, Zhijie Ren, Yajun Pan, Jinjin Jia, Haiwen Zhang, Fenglin Bai, Peng Zhang, Huifen Zhu, Yikun He, Shenglian Luo, Legong Li, Sheng Luan
      Abstract: Carbon dioxide influences plant–water relations and gas exchange by regulating stomatal aperture. Here, Tian et al . characterize RHC1, a MATE family transporter that under elevated carbon dioxide concentrations promotes stomatal closure via activation of the SLAC1 anion channel.
      PubDate: 2015-01-20|2015-01-20
      DOI: 10.1038/ncomms7057
  • Comprehensive bioimaging with fluorinated nanoparticles using breathable
    • Authors: Michael E. Kurczy, Zheng-Jiang Zhu, Julijana Ivanisevic, Adam M. Schuyler, Kush Lalwani, Antonio F. Santidrian, John M. David, Anand Giddabasappa, Amanda J. Roberts, Hernando J. Olivos, Peter J. O’Brien, Lauren Franco, Matthew W. Fields, Liliana P. Paris, Martin Friedlander, Caroline H. Johnson, Adrian A. Epstein, Howard E. Gendelman, Malcolm R. Wood, Brunhilde H. Felding, Gary J. Patti, Mary E. Spilker, Gary Siuzdak
      Abstract: Perfluorinated organic molecules have shown many uses, including as imaging agents. Here, the authors report that fluorinated gold nanoparticles offer an effective means of mass spectrometry tissue imaging, in addition to facilitating X-ray analysis providing complementary information to mass spectral images.
      PubDate: 2015-01-20|2015-01-20
      DOI: 10.1038/ncomms6998
  • Coupling unstable agents in biological control
    • Authors: Theresa Wei Ying Ong, John H. Vandermeer
      Abstract: Control of pests in agriculture by introduced natural enemies may be hampered because of unstable oscillations in the dynamics of the two populations. Here, the authors show that stable conditions can be maintained by combining two unstable systems utilizing different biological control agents.
      PubDate: 2015-01-20|2015-01-20
      DOI: 10.1038/ncomms6991
  • A dynamically coupled allosteric network underlies binding cooperativity
           in Src kinase
    • Authors: Zachariah H. Foda, Yibing Shan, Eric T. Kim, David E. Shaw, Markus A. Seeliger
      Abstract: Protein tyrosine kinases are subject to multiple regulatory mechanisms. Foda et al . show that reactants and products of the tyrosine kinase Src bind its catalytic domain with opposite cooperativity, and identify an allosteric network of dynamically coupled amino acids that underlie this behaviour.
      PubDate: 2015-01-20|2015-01-20
      DOI: 10.1038/ncomms6939
  • Vaginal type-II mucosa is an inductive site for primary CD8+ T-cell
           mucosal immunity
    • Authors: Yichuan Wang, Yongjun Sui, Shingo Kato, Alison E. Hogg, Jason C. Steel, John C. Morris, Jay A. Berzofsky
      Abstract: Priming of naïve T cells is thought to occur in tissue-draining lymph nodes. Here Wang et al . show that vaginal mucosa, despite lacking structured lymphoid organs, can support priming of naïve CD8 T-cell responses and activation of memory CD8 T cells.
      PubDate: 2015-01-20|2015-01-20
      DOI: 10.1038/ncomms7100
  • Origins of multicellular evolvability in snowflake yeast
    • Authors: William C. Ratcliff, Johnathon D. Fankhauser, David W. Rogers, Duncan Greig, Michael Travisano
      Abstract: The first steps in the transition to multicellularity remain poorly understood. Here, the authors demonstrate that disrupting a single gene in yeast results in multicellular clusters that develop clonally and possess a high degree of multicellular heritability, predisposing them to multicellular adaptation.
      PubDate: 2015-01-20|2015-01-20
      DOI: 10.1038/ncomms7102
  • Growth of high-density horizontally aligned SWNT arrays using Trojan
    • Authors: Yue Hu, Lixing Kang, Qiuchen Zhao, Hua Zhong, Shuchen Zhang, Liangwei Yang, Zequn Wang, Jingjing Lin, Qingwen Li, Zhiyong Zhang, Lianmao Peng, Zhongfan Liu, Jin Zhang
      Abstract: Single-walled carbon nanotube arrays have been proposed for use in electronics, but getting the tubes aligned and in high density is a very challenging task. Hu et al . show that catalyst particles dissolved in a substrate can slowly be brought to the surface, allowing continued controlled growth of nanotubes.
      PubDate: 2015-01-20|2015-01-20
      DOI: 10.1038/ncomms7099
  • Flooding disturbances increase resource availability and productivity but
           reduce stability in diverse plant communities
    • Authors: Alexandra J. Wright, Anne Ebeling, Hans de Kroon, Christiane Roscher, Alexandra Weigelt, Nina Buchmann, Tina Buchmann, Christine Fischer, Nina Hacker, Anke Hildebrandt, Sophia Leimer, Liesje Mommer, Yvonne Oelmann, Stefan Scheu, Katja Steinauer, Tanja Strecker, Wolfgang Weisser, Wolfgang Wilcke, Nico Eisenhauer
      Abstract: Most studies investigating the biodiversity–stability hypothesis have focused on disturbances that induce productivity losses. Using data from a 200–year flood event in a grassland biodiversity experiment, Wright et al . show that disturbances that increase productivity can also drive decreased stability.
      PubDate: 2015-01-20|2015-01-20
      DOI: 10.1038/ncomms7092
  • Forbidden atomic transitions driven by an intensity-modulated laser trap
    • Authors: Kaitlin R. Moore, Sarah E. Anderson, Georg Raithel
      Abstract: Atomic spectroscopy is typically based on multipole atom-field interactions that obey established selection rules. Using Rydberg atoms as an example, Moore et al . show that the quadratic (ponderomotive) interaction can provide both more flexible selection rules and greater spatial addressability.
      PubDate: 2015-01-20|2015-01-20
      DOI: 10.1038/ncomms7090
  • Probing the limits of gate-based charge sensing
    • Authors: M. F. Gonzalez-Zalba, S. Barraud, A. J. Ferguson, A. C. Betz
      Abstract: Reading out the state of quantum bits is an essential requirement that any quantum computer implementation must satisfy. Gonzalez-Zalba et al . now show that in situ resonant gate-based detection can be a more sensitive approach than external electrometers while reducing the qubit architecture’s complexity.
      PubDate: 2015-01-20|2015-01-20
      DOI: 10.1038/ncomms7084
  • Nacre-mimetics with synthetic nanoclays up to ultrahigh aspect ratios
    • Authors: Paramita Das, Jani-Markus Malho, Khosrow Rahimi, Felix H. Schacher, Baochun Wang, Dan Eugen Demco, Andreas Walther
      Abstract: Nacre-mimetics hold great promise as high-performance, functional materials. Here, the authors use synthetic nanoclays and demonstrate tuneable mechanical properties by varying the nanoclay aspect ratio, and suggest a transparent gas barrier application.
      PubDate: 2015-01-20|2015-01-20
      DOI: 10.1038/ncomms6967
  • Deviation from high-entropy configurations in the atomic distributions of
           a multi-principal-element alloy
    • Authors: Louis J. Santodonato, Yang Zhang, Mikhail Feygenson, Chad M. Parish, Michael C. Gao, Richard J.K. Weber, Joerg C Neuefeind, Zhi Tang, Peter K Liaw
      Abstract: Alloys containing multiple elements of equal distributions are known to show enhanced properties as they tend to form single phases. Here, the authors demonstrate that even in cases of elemental segregation and chemical ordering, these alloys can still maintain enhanced properties.
      PubDate: 2015-01-20|2015-01-20
      DOI: 10.1038/ncomms6964
  • Abundance of live 244Pu in deep-sea reservoirs on Earth points to rarity
           of actinide nucleosynthesis
    • Authors: A. Wallner, T. Faestermann, J. Feige, C. Feldstein, K. Knie, G. Korschinek, W. Kutschera, A. Ofan, M. Paul, F. Quinto, G. Rugel, P. Steier
      Abstract: The build-up of short-lived nuclides in the interstellar medium tells us about production frequency and yield of heavy elements by nucleosynthesis. Wallner et al . find a low abundance of live interstellar 244Pu detected from the deep-sea floor, suggesting a rarity for r-process nucleosynthesis sites.
      PubDate: 2015-01-20|2015-01-20
      DOI: 10.1038/ncomms6956
  • PFKFB4 controls embryonic patterning via Akt signalling independently of
    • Authors: Caterina Pegoraro, Ana Leonor Figueiredo, Frédérique Maczkowiak, Celio Pouponnot, Alain Eychène, Anne H. Monsoro-Burq
      Abstract: PFKFB4 is an enzyme known to regulate glycolysis. The authors reveal a surprising new role for this protein in global patterning of dorsal ectoderm in frogs that is mediated by Akt signalling and independent of glycolysis.
      PubDate: 2015-01-20|2015-01-20
      DOI: 10.1038/ncomms6953
  • The mitochondrial uniporter controls fight or flight heart rate increases
    • Authors: Yuejin Wu, Tyler P. Rasmussen, Olha M Koval, Mei-ling A. Joiner, Duane D. Hall, Biyi Chen, Elizabeth D. Luczak, Qiongling Wang, Adam G. Rokita, Xander H.T. Wehrens, Long-Sheng Song, Mark E. Anderson
      Abstract: Animals react to threats by increasing their heart rate. Wu et al . show that mitochondrial calcium uptake via a highly selective ion channel, the mitochondrial calcium uniporter, stimulates metabolism in cardiac pacemaker cells and is essential for physiological pulse acceleration but not resting heart rate.
      PubDate: 2015-01-20|2015-01-20
      DOI: 10.1038/ncomms7081
  • Revealing letters in rolled Herculaneum papyri by X-ray phase-contrast
    • Authors: Vito Mocella, Emmanuel Brun, Claudio Ferrero, Daniel Delattre
      Abstract: The explosion of Vesuvius in 79 AD carbonized a library of papyrus scrolls, namely Herculaneum papyri, the contents of which are thus still largely unknown. Here, Mocella et al. show the capability of X-ray phase-contrast tomography to read letters in these scrolls without the need to unroll them first.
      PubDate: 2015-01-20|2015-01-20
      DOI: 10.1038/ncomms6895
  • Clustering of CARMA1 through SH3–GUK domain interactions is required
           for its activation of NF-κB signalling
    • Authors: Hiromitsu Hara, Tadashi Yokosuka, Hideki Hirakawa, Chitose Ishihara, Shinsuke Yasukawa, Masanori Yamazaki, Haruhiko Koseki, Hiroki Yoshida, Takashi Saito
      Abstract: Activating mutations in the NF-κB regulator CARMA1 are associated with a form of B-cell lymphoma. Hara et al . show that both physiological and oncogenic CARMA1 signalling can be inhibited by preventing its activation-induced clustering, which is mediated by its SH3 and GUK domains.
      PubDate: 2015-01-20|2015-01-20
      DOI: 10.1038/ncomms6555
  • A vlincRNA participates in senescence maintenance by relieving
           H2AZ-mediated repression at the INK4 locus
    • Authors: Sandra Lazorthes, Céline Vallot, Sébastien Briois, Marion Aguirrebengoa, Jean-Yves Thuret, Georges St. Laurent, Claire Rougeulle, Philipp Kapranov, Carl Mann, Didier Trouche, Estelle Nicolas
      Abstract: Senescence is associated with chromatin reorganization in heterochromatin foci. Here the authors show that VAD , a very long intergenic non-coding RNA activated by senescence, inhibits the incorporation of the repressive histone variant H2A.Z to INK4 promoters in senescent cells.
      PubDate: 2015-01-20|2015-01-20
      DOI: 10.1038/ncomms6971
  • Three-dimensionally bonded spongy graphene material with super compressive
           elasticity and near-zero Poisson’s ratio
    • Authors: Yingpeng Wu, Ningbo Yi, Lu Huang, Tengfei Zhang, Shaoli Fang, Huicong Chang, Na Li, Jiyoung Oh, Jae Ah Lee, Mikhail Kozlov, Alin C. Chipara, Humberto Terrones, Peishuang Xiao, Guankui Long, Yi Huang, Fan Zhang, Long Zhang, Xavier Lepró, Carter Haines, Márcio Dias Lima, Nestor Perea Lopez, Lakshmy P. Rajukumar, Ana L. Elias, Simin Feng, Seon Jeong Kim, N. T. Narayanan, Pulickel M. Ajayan, Mauricio Terrones, Ali Aliev, Pengfei Chu, Zhong Zhang, Ray H. Baughman, Yongsheng Chen
      Abstract: The incorporation of the desirable properties of graphene into three-dimensional materials remains challenging. Here, the authors report the scalable self-assembly of graphene sheets into spongy materials with very low densities, and near-zero and largely strain-independent Poisson's ratios in all directions.
      PubDate: 2015-01-20|2015-01-20
      DOI: 10.1038/ncomms7141
  • Reputation can enhance or suppress cooperation through positive feedback
    • Authors: John M. McNamara, Polly Doodson
      Abstract: When individuals differ in their cooperative behaviour, it pays to take a partner’s reputation into account when deciding one's own levels of cooperation. Here the authors use game theory to analyse how this feeds back to change levels of cooperation as individuals change their reputation so as to change the behaviour of future partners.
      PubDate: 2015-01-20|2015-01-20
      DOI: 10.1038/ncomms7134
  • Graphene-modified nanostructured vanadium pentoxide hybrids with
           extraordinary electrochemical performance for Li-ion batteries
    • Authors: Qi Liu, Zhe-Fei Li, Yadong Liu, Hangyu Zhang, Yang Ren, Cheng-Jun Sun, Wenquan Lu, Yun Zhou, Lia Stanciu, Eric A. Stach, Jian Xie
      Abstract: Vanadium pentoxide is considered a promising lithium battery electrode, but suffers from poor rate capability and cyclability. Here, the authors synthesize graphene-modified nanostructured vanadium pentoxide and show significant improvement in rate performance and cycle life.
      PubDate: 2015-01-20|2015-01-20
      DOI: 10.1038/ncomms7127
  • Dynamical phases in quenched spin–orbit-coupled degenerate Fermi gas
    • Authors: Ying Dong, Lin Dong, Ming Gong, Han Pu
      Abstract: Spin–orbit-coupled Fermi gases have been shown to support exotic topological quantum states. Here, the authors investigate quench dynamics of these gases in two dimensions, and find that three different phases with different topological properties emerge depending on the behaviour of the order parameter.
      PubDate: 2015-01-20|2015-01-20
      DOI: 10.1038/ncomms7103
  • The unexpected role of polyubiquitin chains in the formation of fibrillar
    • Authors: Daichi Morimoto, Erik Walinda, Harumi Fukada, Yu-Shin Sou, Shun Kageyama, Masaru Hoshino, Takashi Fujii, Hikaru Tsuchiya, Yasushi Saeki, Kyohei Arita, Mariko Ariyoshi, Hidehito Tochio, Kazuhiro Iwai, Keiichi Namba, Masaaki Komatsu, Keiji Tanaka, Masahiro Shirakawa
      Abstract: Ubiquitin is a stable and soluble protein, but it is commonly found in inclusion bodies in neurodegenerative disorders and cancer. Here, Morimoto et al . report that increasing ubiquitin chain length leads to the formation of amyloid-like fibrils, which are degraded by an autophagy mechanism.
      PubDate: 2015-01-20|2015-01-20
      DOI: 10.1038/ncomms7116
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