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  Subjects -> PHYSICS (Total: 798 journals)
    - ELECTRICITY AND MAGNETISM (9 journals)
    - MECHANICS (19 journals)
    - NUCLEAR PHYSICS (49 journals)
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    - PHYSICS (581 journals)
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PHYSICS (581 journals)

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Journal Cover Nature Communications
  [SJR: 6.539]   [H-I: 114]   [122 followers]  Follow
    
  This is an Open Access Journal Open Access journal
   ISSN (Online) 2041-1723
   Published by NPG Homepage  [124 journals]
  • Total synthesis of feglymycin based on a linear/convergent hybrid approach
           using micro-flow amide bond formation
    • Total synthesis of feglymycin based on a linear/convergent hybrid approach using micro-flow amide bond formation

      Nature Communications, Published online: 28 November 2016; doi:10.1038/ncomms13491

      Feglymycin is a biologically active peptide but a challenging synthetic target due to the highly racemizable nature of the 3,5-dihydroxyphenylglycine groups. Here the authors report the synthesis of feglymycin using a microflow system, allowing amide bond formation without severe racemization.

      Nature Communications, Published online: 28 November 2016; doi:10.1038/ncomms134912016-11-28
      DOI: 10.1038/ncomms13491
       
  • Selective suppression of antisense transcription by Set2-mediated H3K36
           methylation
    • Selective suppression of antisense transcription by Set2-mediated H3K36 methylation

      Nature Communications, Published online: 28 November 2016; doi:10.1038/ncomms13610

      Maintenance of chromatin structure in coding regions is partially dependent on transcription, with histone methyltransferase Set2 playing a role in this process. Here, the authors provide evidence that Set2 regulates repression of a specific set of antisense RNAs embedded within the coding genes.

      Nature Communications, Published online: 28 November 2016; doi:10.1038/ncomms136102016-11-28
      DOI: 10.1038/ncomms13610
       
  • Modulation of mRNA and lncRNA expression dynamics by the Set2–Rpd3S
           pathway
    • Modulation of mRNA and lncRNA expression dynamics by the Set2–Rpd3S pathway

      Nature Communications, Published online: 28 November 2016; doi:10.1038/ncomms13534

      H3K36 methylation by Set2 targets Rpd3S histone deacetylase to transcribed mRNA genes, repressing internal cryptic promoters and modulating elongation. Here, the authors provide evidence that the Set2-Rpd3S pathway also regulates dynamic expression of mRNAs and lncRNAs.

      Nature Communications, Published online: 28 November 2016; doi:10.1038/ncomms135342016-11-28
      DOI: 10.1038/ncomms13534
       
  • IL-12 protects from psoriasiform skin inflammation
    • IL-12 protects from psoriasiform skin inflammation

      Nature Communications, Published online: 28 November 2016; doi:10.1038/ncomms13466

      IL-12 and IL-23 share the common p40 subunit yet have distinct immunological functions with IL-12 typically contributing to Th1 responses and IL-23 to Th17 responses. Here the authors show that current p40 based therapies for psoriasis are counterproductive owing to an IFN-γ-independent tissue protective function of IL-12 in skin.

      Nature Communications, Published online: 28 November 2016; doi:10.1038/ncomms134662016-11-28
      DOI: 10.1038/ncomms13466
       
  • Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases
           LDL-C and attenuates atherosclerosis
    • Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis

      Nature Communications, Published online: 28 November 2016; doi:10.1038/ncomms13457

      Statins are lipid-lowering drugs that prevent cardiovascular disease but tolerability is limited by severe side effects in muscles. Here the authors elucidate a liver-specific activation mechanism for bempedoic acid, a novel cholesterol-lowering drug, and show how it effectively reduces LDL-C and atherosclerotic burden in mice, but does not cause myotoxicty.

      Nature Communications, Published online: 28 November 2016; doi:10.1038/ncomms134572016-11-28
      DOI: 10.1038/ncomms13457
       
  • Amplification of USP13 drives ovarian cancer metabolism
    • Amplification of USP13 drives ovarian cancer metabolism

      Nature Communications, Published online: 28 November 2016; doi:10.1038/ncomms13525

      Cancer cells need to reprogramme their metabolism to allow rapid cell proliferation. Here, the authors show that USP13 is amplified in ovarian cancer and its protein product, a deubiquitinase, drives tumour progression by rewiring the metabolism of cancer cells by stabilising two critical metabolic enzymes.

      Nature Communications, Published online: 28 November 2016; doi:10.1038/ncomms135252016-11-28
      DOI: 10.1038/ncomms13525
       
  • Reconfigurable exciton-plasmon interconversion for nanophotonic circuits
    • Reconfigurable exciton-plasmon interconversion for nanophotonic circuits

      Nature Communications, Published online: 28 November 2016; doi:10.1038/ncomms13663

      Here the authors demonstrate functionality for on-chip optical communications via reconfigurable exciton-plasmon interconversion in 200 nm-diameter silver nanowires overlapping onto two-dimensional transition metal dichalcogenide transistors.

      Nature Communications, Published online: 28 November 2016; doi:10.1038/ncomms136632016-11-28
      DOI: 10.1038/ncomms13663
       
  • Atomistic characterization of the active-site solvation dynamics of a
           model photocatalyst
    • Atomistic characterization of the active-site solvation dynamics of a model photocatalyst

      Nature Communications, Published online: 28 November 2016; doi:10.1038/ncomms13678

      Interactions between reactive excited states of molecular photocatalysts and surrounding solvent can dictate reaction pathways, but are not readily accessible to conventional spectroscopic methods. Here the authors use diffuse X-ray scattering and theory to study the atomistic solvation dynamics of a photoexcited di-iridium complex in acetonitrile.

      Nature Communications, Published online: 28 November 2016; doi:10.1038/ncomms136782016-11-28
      DOI: 10.1038/ncomms13678
       
 
 
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