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  Subjects -> NUTRITION AND DIETETICS (Total: 215 journals)
Showing 1 - 64 of 64 Journals sorted alphabetically
Acta Portuguesa de Nutrição     Open Access   (Followers: 1)
Advances in Digestive Medicine     Open Access   (Followers: 15)
Advances in Eating Disorders : Theory, Research and Practice     Hybrid Journal   (Followers: 20)
Advances in Food and Nutrition Research     Full-text available via subscription   (Followers: 73)
Advances in Nutrition     Hybrid Journal   (Followers: 64)
African Journal of Biomedical Research     Open Access   (Followers: 1)
African Journal of Food, Agriculture, Nutrition and Development     Open Access   (Followers: 27)
Aktuelle Ernährungsmedizin     Hybrid Journal   (Followers: 6)
Alimentos e Nutrição     Open Access   (Followers: 2)
American Journal of Botany     Full-text available via subscription   (Followers: 17)
American Journal of Clinical Nutrition     Hybrid Journal   (Followers: 242)
American Journal of Food and Nutrition     Open Access   (Followers: 60)
American Journal of Food Technology     Open Access   (Followers: 11)
Amerta Nutrition     Open Access  
Amino Acids     Hybrid Journal   (Followers: 8)
Annals of Nutrition and Metabolism     Full-text available via subscription   (Followers: 65)
Annual Review of Food Science and Technology     Full-text available via subscription   (Followers: 15)
Annual Review of Nutrition     Full-text available via subscription   (Followers: 43)
Appetite     Hybrid Journal   (Followers: 24)
Arab Journal of Nutrition and Exercise     Open Access   (Followers: 1)
Arbor Clinical Nutrition Updates     Full-text available via subscription   (Followers: 5)
Archive of Food and Nutritional Science     Open Access   (Followers: 2)
Archivos Latinoamericanos de Nutrición     Open Access   (Followers: 2)
Asia Pacific Journal of Clinical Nutrition     Full-text available via subscription   (Followers: 13)
Asian Journal of Clinical Nutrition     Open Access   (Followers: 14)
Australian Coeliac     Full-text available via subscription   (Followers: 2)
Bangladesh Journal of Nutrition     Open Access   (Followers: 7)
Better Nutrition     Full-text available via subscription   (Followers: 3)
Bioactive Carbohydrates and Dietary Fibre     Hybrid Journal   (Followers: 3)
Biomedicine & Preventive Nutrition     Partially Free   (Followers: 8)
BMC Nutrition     Open Access   (Followers: 11)
BMJ Nutrition, Prevention & Health     Open Access   (Followers: 5)
British Journal Of Nutrition     Hybrid Journal   (Followers: 102)
Cahiers de Nutrition et de Diététique     Full-text available via subscription   (Followers: 5)
Canadian Food Studies / La Revue canadienne des études sur l'alimentation     Open Access   (Followers: 1)
Canadian Journal of Dietetic Practice and Research     Full-text available via subscription   (Followers: 14)
Case Reports in Clinical Nutrition     Open Access   (Followers: 1)
Childhood Obesity     Hybrid Journal   (Followers: 24)
Clinical Nutrition     Hybrid Journal   (Followers: 96)
Clinical Nutrition ESPEN     Hybrid Journal   (Followers: 21)
Clinical Nutrition Experimental     Open Access   (Followers: 1)
Clinical Nutrition Insight     Full-text available via subscription   (Followers: 14)
Clinical Nutrition Supplements     Hybrid Journal   (Followers: 16)
Clinical Obesity     Hybrid Journal   (Followers: 19)
Comparative Exercise Physiology     Hybrid Journal   (Followers: 25)
Current Developments in Nutrition     Open Access   (Followers: 5)
Current Nutrition & Food Science     Hybrid Journal   (Followers: 28)
Current Nutrition Reports     Hybrid Journal   (Followers: 9)
Current Opinion in Clinical Nutrition & Metabolic Care     Hybrid Journal   (Followers: 23)
Current Research in Nutrition and Food Science     Open Access   (Followers: 6)
DEMETRA : Alimentação, Nutrição & Saúde     Open Access  
Diabetes, Metabolic Syndrome and Obesity     Open Access   (Followers: 50)
Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity     Hybrid Journal   (Followers: 24)
Ecology of Food and Nutrition     Hybrid Journal   (Followers: 9)
Egyptian Journal of Obesity, Diabetes and Endocrinology     Open Access   (Followers: 1)
Endocrinología y Nutrición     Full-text available via subscription   (Followers: 2)
Endocrinología y Nutrición (English Edition)     Full-text available via subscription   (Followers: 2)
Ernährung & Medizin     Hybrid Journal   (Followers: 4)
European Journal of Clinical Nutrition     Hybrid Journal   (Followers: 82)
European Journal of Nutrition     Hybrid Journal   (Followers: 41)
European Journal of Nutrition & Food Safety     Open Access   (Followers: 3)
Flavour     Open Access   (Followers: 3)
Food & Nutrition Research     Open Access   (Followers: 36)
Food and Environmental Virology     Hybrid Journal   (Followers: 1)
Food and Foodways: Explorations in the History and Culture of     Hybrid Journal   (Followers: 10)
Food and Health     Open Access   (Followers: 1)
Food and Nutrition Bulletin     Hybrid Journal   (Followers: 6)
Food and Waterborne Parasitology     Open Access  
Food Digestion     Hybrid Journal   (Followers: 5)
Food Quality and Safety     Open Access   (Followers: 1)
Food Science & Nutrition     Open Access   (Followers: 61)
Food, Culture and Society: An International Journal of Multidisciplinary Research     Full-text available via subscription   (Followers: 11)
Frontiers in Nutrition     Open Access   (Followers: 11)
Frontiers in Sustainable Food Systems     Open Access   (Followers: 1)
Functional Foods in Health and Disease     Open Access  
Gazi Sağlık Bilimleri Dergisi     Open Access  
Genes & Nutrition     Open Access   (Followers: 9)
Hacettepe University Faculty of Health Sciences Journal     Open Access  
Harran Tarım ve Gıda Bilimleri Dergisi     Open Access   (Followers: 1)
Indian Journal of Nutrition and Dietetics     Hybrid Journal   (Followers: 1)
Indonesian Food and Nutrition Progress     Open Access  
International Journal for Vitamin and Nutrition Research     Hybrid Journal   (Followers: 12)
International Journal of Behavioral Nutrition and Physical Activity     Open Access   (Followers: 30)
International Journal of Child Health and Nutrition     Hybrid Journal   (Followers: 7)
International Journal of Eating Disorders     Hybrid Journal   (Followers: 31)
International Journal of Food Safety, Nutrition and Public Health     Hybrid Journal   (Followers: 23)
International Journal of Food Science and Nutrition Engineering     Open Access   (Followers: 10)
International Journal of Food Sciences and Nutrition     Hybrid Journal   (Followers: 12)
International Journal of Nutrition and Metabolism     Open Access   (Followers: 24)
International Journal of Nutrition, Pharmacology, Neurological Diseases     Open Access   (Followers: 4)
International Journal of Nutrology     Open Access  
International Journal of Obesity     Hybrid Journal   (Followers: 94)
International Journal of Sport Nutrition & Exercise Metabolism     Hybrid Journal   (Followers: 88)
Intrinsically Disordered Proteins     Hybrid Journal  
Journal of Acupuncture and Herbs     Open Access   (Followers: 3)
Journal of Agriculture, Food Systems, and Community Development     Open Access   (Followers: 1)
Journal of Dietary Supplements     Hybrid Journal   (Followers: 11)
Journal of Eating Disorders     Open Access   (Followers: 11)
Journal of Ethnic Foods     Open Access   (Followers: 2)
Journal of Food & Nutritional Disorders     Hybrid Journal   (Followers: 2)
Journal of Food and Nutrition Research     Open Access   (Followers: 11)
Journal of Food Chemistry and Nutrition     Open Access   (Followers: 6)
Journal of Food Science and Nutrition Therapy     Open Access   (Followers: 2)
Journal of Health, Population and Nutrition     Open Access   (Followers: 10)
Journal of Human Nutrition and Dietetics     Hybrid Journal   (Followers: 51)
Journal of Hunger & Environmental Nutrition     Hybrid Journal   (Followers: 6)
Journal of Medical Nutrition and Nutraceuticals     Open Access   (Followers: 3)
Journal of Medicinal Herbs and Ethnomedicine     Open Access  
Journal of Muscle Foods     Hybrid Journal  
Journal of Nutraceuticals and Herbal Medicine     Open Access   (Followers: 4)
Journal of Nutrition     Hybrid Journal   (Followers: 40)
Journal of Nutrition & Food Sciences     Open Access   (Followers: 6)
Journal of Nutrition & Intermediary Metabolism     Open Access  
Journal of Nutrition and Metabolism     Open Access   (Followers: 17)
Journal of Nutrition Education and Behavior     Hybrid Journal   (Followers: 21)
Journal of Nutrition in Gerontology and Geriatrics     Hybrid Journal   (Followers: 15)
Journal of Nutrition, Health and Aging     Hybrid Journal   (Followers: 31)
Journal of Nutritional & Environmental Medicine     Full-text available via subscription   (Followers: 2)
Journal of Nutritional Biochemistry     Hybrid Journal   (Followers: 8)
Journal of Nutritional Disorders & Therapy     Open Access  
Journal of Nutritional Ecology and Food Research     Full-text available via subscription  
Journal of Nutritional Science     Open Access   (Followers: 3)
Journal of Nutritional Therapeutics     Hybrid Journal   (Followers: 2)
Journal of Obesity     Open Access   (Followers: 27)
Journal of Parenteral and Enteral Nutrition     Hybrid Journal   (Followers: 33)
Journal of Pediatric Gastroenterology and Nutrition (JPGN)     Hybrid Journal   (Followers: 50)
Journal of Pharmacy and Nutrition Sciences     Open Access   (Followers: 8)
Journal of Probiotics & Health     Open Access   (Followers: 1)
Journal of Renal Nutrition     Hybrid Journal   (Followers: 28)
Journal of Renal Nutrition and Metabolism     Open Access   (Followers: 1)
Journal of Sensory Studies     Hybrid Journal   (Followers: 4)
Journal of Spices and Aromatic Crops     Open Access  
Journal of the Academy of Nutrition and Dietetics     Full-text available via subscription   (Followers: 60)
Journal of the American College of Nutrition     Hybrid Journal   (Followers: 8)
Journal of the American Dietetic Association     Full-text available via subscription   (Followers: 27)
Journal of the Australasian College of Nutritional and Environmental Medicine     Full-text available via subscription  
Jurnal Gizi dan Dietetik Indonesia : Indonesian Journal of Nutrition and Dietetics     Open Access   (Followers: 4)
Jurnal Gizi dan Pangan     Open Access   (Followers: 2)
Jurnal Gizi Indonesia / The Indonesian Journal of Nutrition     Open Access   (Followers: 3)
Jurnal Gizi Klinik Indonesia     Open Access   (Followers: 1)
Jurnal Penelitian Gizi dan Makanan     Open Access   (Followers: 4)
Jurnal Riset Kesehatan     Open Access  
La Ciencia al Servicio de la Salud y Nutrición     Open Access   (Followers: 1)
Lifestyle Genomics     Open Access   (Followers: 4)
Lifestyle Journal     Open Access   (Followers: 1)
Maternal & Child Nutrition     Hybrid Journal   (Followers: 13)
Médecine & Nutrition     Full-text available via subscription  
Media Gizi Indonesia     Open Access   (Followers: 1)
Metabolism and Nutrition in Oncology     Open Access   (Followers: 4)
Molecular Nutrition & Food Research     Hybrid Journal   (Followers: 8)
NFS Journal     Open Access  
Nigerian Food Journal     Full-text available via subscription   (Followers: 2)
Nigerian Journal of Nutritional Sciences     Full-text available via subscription  
Nutrafoods     Hybrid Journal  
Nutrición Hospitalaria     Open Access   (Followers: 4)
Nutridate     Full-text available via subscription   (Followers: 1)
Nutrients     Open Access   (Followers: 11)
Nutrire     Hybrid Journal   (Followers: 2)
Nutrition     Hybrid Journal   (Followers: 22)
Nutrition & Diabetes     Open Access   (Followers: 21)
Nutrition & Dietetics     Hybrid Journal   (Followers: 29)
Nutrition & Metabolism     Open Access   (Followers: 13)
Nutrition - Science en évolution     Full-text available via subscription   (Followers: 2)
Nutrition : X     Open Access   (Followers: 1)
Nutrition Action Health Letter     Free   (Followers: 3)
Nutrition and Cancer     Hybrid Journal   (Followers: 11)
Nutrition and Dietary Supplements     Open Access   (Followers: 14)
Nutrition and Health     Hybrid Journal   (Followers: 9)
Nutrition and Metabolic Insights     Open Access   (Followers: 4)
Nutrition Bulletin     Hybrid Journal   (Followers: 8)
Nutrition Bytes     Open Access   (Followers: 6)
Nutrition in Clinical Practice     Hybrid Journal   (Followers: 43)
Nutrition Journal     Open Access   (Followers: 8)
Nutrition Research     Hybrid Journal   (Followers: 21)
Nutrition Research Reviews     Hybrid Journal   (Followers: 13)
Nutrition Reviews     Hybrid Journal   (Followers: 33)
Nutrition Today     Hybrid Journal   (Followers: 12)
Nutrition, Metabolism and Cardiovascular Diseases     Hybrid Journal   (Followers: 12)
Nutritional Neuroscience : An International Journal on Nutrition, Diet and Nervous System     Hybrid Journal   (Followers: 8)
Obésité     Hybrid Journal   (Followers: 1)
Obesity     Hybrid Journal   (Followers: 58)
Obesity Facts     Open Access   (Followers: 9)
Obesity Reviews     Hybrid Journal   (Followers: 26)
Open Food Science Journal     Open Access  
Open Nutrition Journal     Open Access   (Followers: 1)
Open Obesity Journal     Open Access   (Followers: 1)
Pakistan Journal of Nutrition     Open Access   (Followers: 2)
Pediatric Obesity     Hybrid Journal   (Followers: 9)
Perspectivas en Nutrición Humana     Open Access   (Followers: 1)
PharmaNutrition     Hybrid Journal   (Followers: 1)
Plant Foods for Human Nutrition     Hybrid Journal   (Followers: 5)
Plant Production Science     Open Access  
Procedia Food Science     Open Access  
Proceedings of the Nutrition Society     Hybrid Journal   (Followers: 8)
Progress in Nutrition     Open Access   (Followers: 1)
Public Health Nutrition     Hybrid Journal   (Followers: 28)
RBNE - Revista Brasileira de Nutrição Esportiva     Open Access   (Followers: 1)
RBONE - Revista Brasileira de Obesidade, Nutrição e Emagrecimento     Open Access  
Recent Patents on Food, Nutrition & Agriculture     Hybrid Journal  
Revista Chilena de Nutricion     Open Access   (Followers: 2)

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Lifestyle Genomics
Journal Prestige (SJR): 0.614
Citation Impact (citeScore): 2
Number of Followers: 4  

  This is an Open Access Journal Open Access journal
ISSN (Print) 2504-3161 - ISSN (Online) 2504-3188
Published by Karger Homepage  [120 journals]
  • Analysis of the Interaction between Polygenic Risk Score and Calorie
           Intake in Obesity in the Korean Population

    • Abstract: Introduction: Obesity results from an imbalance in the intake and expenditure of calories that leads to lifestyle-related diseases. Although genome-wide association studies (GWAS) have revealed many obesity-related genetic factors, the interactions of these factors and calorie intake remain unknown. This study aimed to investigate interactions between calorie intake and the polygenic risk score (PRS) of BMI. Methods: Three cohorts, i.e., from the Korea Association REsource (KARE; n = 8,736), CArdioVAscular Disease Association Study (CAVAS; n = 9,334), and Health EXAminee (HEXA; n = 28,445), were used for this study. BMI-related genetic loci were selected from previous GWAS. Two scores, PRS, and association (a)PRS, were used; the former was determined from 193 single-nucleotide polymorphisms (SNPs) from 5 GWAS datasets, and the latter from 62 SNPs (potentially associated) from 3 Korean cohorts (meta-analysis, p #x3c; 0.01). Results: PRS and aPRS were significantly associated with BMI in all 3 cohorts but did not exhibit a significant interaction with total calorie intake. Similar results were obtained for obesity. PRS and aPRS were significantly associated with obesity but did not show a significant interaction with total calorie intake. We further analyzed the interaction with protein, fat, and carbohydrate intake. The results were similar to those for total calorie intake, with PRS and aPRS found to not be associated with the interaction of any of the 3 nutrition components for either BMI or obesity. Discussion: The interaction of BMI PRS with calorie intake was investigated in 3 independent Korean cohorts (total n = 35,094) and no interactions were found between PRS and calorie intake for obesity.
      Lifestyle Genomics
      PubDate: Thu, 10 Dec 2020 10:43:02 +010
  • Quantile-Dependent Expressivity and Gene-Lifestyle Interactions Involving
           High-Density Lipoprotein Cholesterol

    • Abstract: Background: The phenotypic expression of a high-density lipoprotein (HDL) genetic risk score has been shown to depend upon whether the phenotype (HDL-cholesterol) is high or low relative to its distribution in the population (quantile-dependent expressivity). This may be due to the effects of genetic mutations on HDL-metabolism being concentration dependent. Method: The purpose of this article is to assess whether some previously reported HDL gene-lifestyle interactions could potentially be attributable to quantile-dependent expressivity. Summary:Seventy-three published examples of HDL gene-lifestyle interactions were interpreted from the perspective of quantile-dependent expressivity. These included interactive effects of diet, alcohol, physical activity, adiposity, and smoking with genetic variants associated with the ABCA1, ADH3, ANGPTL4, APOA1, APOA4, APOA5, APOC3, APOE, CETP, CLASP1, CYP7A1, GALNT2, LDLR, LHX1, LIPC, LIPG, LPL, MVK-MMAB, PLTP, PON1, PPARα, SIRT1, SNTA1,and UCP1genes. The selected examples showed larger genetic effect sizes for lifestyle conditions associated with higher vis-à-vis lower average HDL-cholesterol concentrations. This suggests these reported interactions could be the result of selecting subjects for conditions that differentiate high from low HDL-cholesterol (e.g., lean vs. overweight, active vs. sedentary, high-fat vs. high-carbohydrate diets, alcohol drinkers vs. abstainers, nonsmokers vs. smokers) producing larger versus smaller genetic effect sizes. Key Message: Quantile-dependent expressivity provides a potential explanation for some reported gene-lifestyle interactions for HDL-cholesterol. Although overall genetic heritability appears to be quantile specific, this may vary by genetic variant and environmental exposure.
      Lifestyle Genomics
      PubDate: Wed, 09 Dec 2020 09:36:56 +010
  • Acknowledgement to Reviewers

    • Abstract:
      Lifestyle Genomics 2020;13:187
      PubDate: Tue, 24 Nov 2020 10:32:32 +010
  • A Metabolically Unhealthy Phenotype Is Associated with ADIPOQ Genetic
           Variants and Lower Serum Adiponectin Levels

    • Abstract: Background: Even though excessive adipose tissue is related to chronic metabolic disturbances, not all subjects with excess weight (EW) display metabolic alterations, and not all normal-weight (NW) subjects have a metabolically healthy (MH) phenotype, probably due to gene-environment interactions. The aim of this study was to investigate the interaction effects of ADIPOQ and PPARG genetic variants in NW and EW individuals with different metabolic phenotypes. Methods: Data on 345 adults from western Mexico were analyzed. The individuals were classified into NW and EW groups according to body mass index, and were categorized as MH or metabolically unhealthy (MUH), considering homeostatic model assessment insulin resistance (HOMA-IR) and National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) cut-off points for glucose, triglycerides, high-density lipoprotein cholesterol, and blood pressure. Subjects with ≤1 altered parameter were classified as MH. The single nucleotide polymorphisms (SNPs) –11377C#x3e;G, –11391G#x3e;A, +45T#x3e;G, and +276G#x3e;T for ADIPOQ and Pro12Ala for PPARG were analyzed by allelic discrimination. High-molecular-weight adiponectin isoform levels were measured by ELISA. Results: Lower serum adiponectin levels were associated with the MUH phenotype in EW subjects. NW subjects with the GG or TG genotype for the +45T#x3e;G SNP had reduced odds of the MUH phenotype. Individuals who carried two copies of the GG haplotype at the –11391G#x3e;A and –11377C#x3e;G SNPs for ADIPOQ had lower serum adiponectin levels than those with zero copies. Conclusion: In this population, lower serum adiponectin levels were found in the EW-MUH phenotype, and no differences were observed between the NW-MH and the EW-MH phenotype. In addition, the +45T#x3e;G SNP was associated with reduced odds of the MUH phenotype.
      Lifestyle Genomics
      PubDate: Mon, 02 Nov 2020 14:12:00 +010
  • Genetic Variants in Lipid Metabolism Pathways Interact with Diet to
           Influence Blood Lipid Concentrations in Adults with Overweight and Obesity

    • Abstract: Introduction: The effect of various types of dietary fat on cardiometabolic health continues to be debated, due in part to the high heterogeneity of results following clinical trials investigating the effects of saturated (SFA) and unsaturated fat intake. This variability may be due to genetic differences. Individuals with obesity are at an increased risk for adverse cardiometabolic health and dyslipidemia, and often present with the combined phenotype of elevated triglyceride (TG) and decreased high-density lipoprotein (HDL) cholesterol concentrations. Studying genetic variants relevant to lipid and lipoprotein metabolism can elucidate the mechanisms by which diet might interact with genotype to influence these phenotypes. The objective of this study was to determine relationships of genetic variation, dietary fat intake, and blood lipid concentrations in adults with overweight and obesity. Methods: Genomic DNA, blood lipid concentrations (HDL and TG), and 7-day diet records were obtained from 101 adults (25–45 years of age) with overweight or obesity. Resting energy expenditure (REE) was measured using indirect calorimetry and used to determine implausible intakes using a modified Goldberg method (kilocalories/REE). Genetic variants included 23 single-nucleotide polymorphisms (SNPs) from 15 genes in lipid metabolism pathways. Variants were analyzed with dietary fat intake (total fat, SFA, monounsaturated fat [MUFA], and polyunsaturated fat [PUFA]) via regression analyses. All models were adjusted for age, sex, ancestry, visceral adipose tissue mass, and total kilocalorie intake. The Bonferroni correction was applied for multiple comparisons. Results: Two interactions were detected for TG concentrations. Five gene-diet interactions were associated with HDL concentrations. There was a significant interaction detected between the rs5882 variant of cholesterol-esterase transfer protein (CETP) and MUFA intake to associate with TG concentrations (interaction p = 0.004, R2 = 0.306). Among carriers of the CETP-rs5882 major allele (G), TG concentrations were significantly lower in individuals consuming more than the median MUFA intake (31 g/day) than in those with an intake below the median. Total dietary fat intake interacted with the rs13702 polymorphism of lipoprotein lipase (LPL) to associate with HDL concentrations (interaction p = 0.041, R2 = 0.419), by which individuals with the risk allele (G) had significantly higher HDL concentrations when consuming a higher-fat diet (#x3e;92 g/day) than those with a lower-fat diet (56 ± 3 vs. 46 ± 2 mg/dL, p = 0.033). Conclusions: Interactions between dietary intake and genes in lipid metabolism pathways were found to be associated with blood lipid concentrations in adults with overweight and obesity. Fatty acid intake may not modulate blood lipid concentrations uniformly across all individuals. Additional research is needed to determine the biological causes of individual variability in response to dietary intake. Understanding the influence of nutrigenetic interactions on dyslipidemia can aid in the development and implementation of personalized dietary strategies to improve health.
      Lifestyle Genomics
      PubDate: Mon, 26 Oct 2020 07:56:44 +010
  • Serum Lipid and Adiponectin Improvements after a Mediterranean Dietary
           Pattern in Non-G-Allele Carriers of the Variant rs3774261

    • Abstract: Background: The role of adiponectin (ADIPOQ) polymorphisms in weight loss and serum lipid changes following different dietary interventions remain unclear. The Mediterranean dietary pattern has been associated with improved cardiovascular risk factors in different studies. Objective: Our aim was to analyze the effects of a hypocaloric diet with a Mediterranean dietary pattern on the metabolic response and adiposity parameters, taking into account the 712 G/A rs3774261 polymorphisms in ADIPOQ. Design: A population of 135 obese patients was enrolled. Anthropometric and serum parameters (lipid profile, insulin, homeostasis model assessment for insulin resistance [HOMA-IR], glucose, C-reactive protein [CRP], adiponectin, resistin, and leptin levels) were measured before and after the dietary intervention (12 weeks). All of the patients were genotyped for the rs3774261 polymorphism. Results: The genotype distribution of this population was 36 patients with AA (26.7%), 68 patients with AG (50.4%), and 31 patients with GG (22.9%). After the dietary intervention and in both genotypes, BMI, weight, fat mass, systolic blood pressure, waist circumference, glucose, insulin, HOMA-IR, and leptin levels all decreased. After the dietary intervention with secondary weight loss and in non-G-allele carriers (AA vs. AG+GG), total cholesterol (Δ = –15.7 ± 3.9 vs. –4.9 ± 2.9 mg/dL; p = 0.02), LDL cholesterol (Δ = –15.3 ± 3.8 vs. –1.7 ± 1.9 mg/dL; p = 0.01), triglyceride levels (Δ = –23.4 ± 5.6 vs. 2.3 ± 2.3 mg/dL; p = 0.01), and CRP (Δ = –1.1 ± 0.1 vs. –0.4 ± 0.2 mg/dL; p = 0.01) decreased. Adiponectin levels (Δ = 7.2 ± 2.1 vs. –0.4 ± 0.3 ng/dL; p = 0.02) increased. Notably, G-allele carriers did not show this improvement. Conclusion: Non-G-allele carriers of the ADIPOQ variant (rs3774261) showed significant improvement in serum levels of adiponectin, lipid profiles, and CRP in response to a hypocaloric diet with a Mediterranean dietary pattern.
      Lifestyle Genomics
      PubDate: Mon, 19 Oct 2020 11:22:57 +020
  • Can a Lifestyle Genomics Intervention Motivate Patients to Engage in
           Greater Physical Activity than a Population-Based Intervention'
           Results from the NOW Randomized Controlled Trial

    • Abstract: Background: Lifestyle genomics (LGx) is a science that explores interactions between genetic variation, lifestyle components such as physical activity (PA), and subsequent health- and performance-related outcomes. The objective of this study was to determine whether an LGx intervention could motivate enhanced engagement in PA to a greater extent than a population-based intervention. Methods: In this pragmatic randomized controlled trial, participants received either the standard, population-based Group Lifestyle BalanceTM (GLB) program intervention or the GLB program in addition to the provision of LGx information and advice (GLB + LGx). Participants (n = 140) completed a 7-day PA recall at baseline, 3, 6, and 12 months. Data from the PA recalls were used to calculate metabolic equivalents (METs), a measure of energy expenditure. Statistical analyses included split plot analyses of covariance and binary logistic regression (generalized linear models). Differences in leisure time PA weekly METs, weekly minutes of moderate + high-intensity PA, and adherence to PA guidelines were compared between groups (GLB and GLB + LGx) across the 4 time points. Results: Weekly METs were significantly higher in the GLB + LGx group (1,114.7 ± 141.9; 95% CI 831.5–1,397.8) compared to the standard GLB group (621.6 ± 141.9 MET/week; 95% CI 338.4–904.8) at the 6-month follow-up (p = 0.01). All other results were non-significant. Conclusions: The provision of an LGx intervention resulted in a greater weekly leisure time PA energy expenditure after the 6-month follow-up. Future research should determine how this could be sustained over the long-term. Clinical Trial Registration: NCT03015012.
      Lifestyle Genomics
      PubDate: Thu, 01 Oct 2020 09:19:05 +020
  • Alpinia zerumbet and Its Potential Use as an Herbal Medication for
           Atherosclerosis: Mechanistic Insights from Cell and Rodent Studies

    • Abstract: Background/Aims: Alpinia zerumbet (Pers.) Burtt. et Smith has been used as a flavor additive in food and a traditional medicine for centuries, especially in Guizhou Province, China, and it prolongs people’s lives with multiple beneficial effects. Thus, one of the aims of this review was to expound the chemical constituents of this plant, especially its fruits. Since cardiovascular diseases, including atherosclerosis, pose a health threat to humans, another aim was to expound the possible mechanisms of its potential use as an herbal medication for atherosclerosis. Methods: In this study, 10 reports are cited to expound the potential bioactive compounds. Moreover, 33 reports explain the antihypertensive and antiatherosclerotic effects of the plant by ameliorating inflammation and endothelial dysfunction, increasing vasodilation, improving hyperlipidemia, downgrading the glucose status, and working as an antioxidant. Results: A. zerumbetis rich in terpenes, essential oils, flavonoids, polyphenolics, and sterols. Pharmacological experiments showed that A. zerumbet has antioxidative and anti-inflammatory effects on the NF-κB signaling pathway and can ameliorate oxidative stress in the NOS-NO signaling pathway. Moreover, A. zerumbet demonstrates antihypertensive effects by accelerating vasorelaxant response and increasing 3T3-L1 intracellular cAMP, which has promising antiobesity properties, as well as hypolipidemic and anti-diabetic complication effects. Conclusions: A. zerumbet has potential functions and applications in the prevention of atherosclerosis, but further studies are required before clinical trials.
      Lifestyle Genomics
      PubDate: Thu, 03 Sep 2020 11:18:41 +020
  • Investigation of the Causal Association between Long-Chain n-6
           Polyunsaturated Fatty Acid Synthesis and the Risk of Type 2 Diabetes: A
           Mendelian Randomization Analysis

    • Abstract: Background: Globally, 1 in 11 adults has diabetes mellitus, and most of these cases are type 2 diabetes (T2D). The risk of T2D is influenced by many factors, including diet. The synthesis of long-chain n-6 polyunsaturated fatty acids (LC n-6 PUFA) has been posited as a risk factor for T2D; however, its causal role is uncertain. Aim: To test the causal effect of LC n-6 PUFA synthesis on insulin resistance and transgenerational T2D risk in a large cohort of men and women. Methods: Two-sample mendelian randomization (MR) was conducted to evaluate the effect of low or high levels of LC n-6 PUFA synthesis on glycemia and development of T2D in the UK Biobank (n = 463,010) and Meta-Analysis of Glucose- and Insulin-Related Traits Consortium (MAGIC; n = 5,130) cohorts. The increased likelihood of a predisposition to low or high LC n-6 PUFA synthesis and the risk of T2D was also investigated using the participants’ siblings and parents. In MR-Base, 4 genetic variants associated with LC n-6 PUFA synthesis were found (p #x3c; 10–8). After pruning, 1 variant (rs174547) on the FADS1 gene was retained. Results: Lower LC n-6 PUFA synthesis and abundance (per % unit decrease) are associated with small reductions in the insulin disposition index (–0.038 ± 0.012 mM–1; p = 0.002) within MAGIC. In the UK Biobank, we report negligible effects of low n-6 PUFA synthesis on the odds of T2D (OR #x3c;1%; p #x3c; 0.05). Additionally, reduced LC n-6 PUFA synthesis does not appear to be a contributor to familial T2D risk. No significant association was observed between LC n-6 PUFA synthesis and BMI. Conclusion: In a primarily white European population, LC n-6 PUFA synthesis is not a major contributor to T2D risk.
      Lifestyle Genomics
      PubDate: Thu, 13 Aug 2020 15:21:13 +020
  • The Covid-19 Global Pandemic: A Natural Experiment in the Making

    • Abstract:
      Lifestyle Genomics
      PubDate: Fri, 07 Aug 2020 07:10:16 +020
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