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  Subjects -> HEALTH AND SAFETY (Total: 1304 journals)
    - CIVIL DEFENSE (19 journals)
    - DRUG ABUSE AND ALCOHOLISM (87 journals)
    - HEALTH AND SAFETY (532 journals)
    - HEALTH FACILITIES AND ADMINISTRATION (377 journals)
    - OCCUPATIONAL HEALTH AND SAFETY (106 journals)
    - PHYSICAL FITNESS AND HYGIENE (101 journals)
    - WOMEN'S HEALTH (82 journals)

HEALTH AND SAFETY (532 journals)                  1 2 3 | Last

Showing 1 - 200 of 203 Journals sorted alphabetically
16 de Abril     Open Access  
A Life in the Day     Hybrid Journal   (Followers: 10)
Acta Informatica Medica     Open Access   (Followers: 1)
Acta Scientiarum. Health Sciences     Open Access  
Adultspan Journal     Hybrid Journal  
Advances in Child Development and Behavior     Full-text available via subscription   (Followers: 10)
Advances in Public Health     Open Access   (Followers: 23)
African Health Sciences     Open Access   (Followers: 2)
African Journal for Physical, Health Education, Recreation and Dance     Full-text available via subscription   (Followers: 6)
African Journal of Health Professions Education     Open Access   (Followers: 6)
Afrimedic Journal     Open Access   (Followers: 2)
Air Quality, Atmosphere & Health     Hybrid Journal   (Followers: 3)
AJOB Primary Research     Partially Free   (Followers: 3)
American Journal of Family Therapy     Hybrid Journal   (Followers: 11)
American Journal of Health Economics     Full-text available via subscription   (Followers: 13)
American Journal of Health Education     Hybrid Journal   (Followers: 31)
American Journal of Health Promotion     Hybrid Journal   (Followers: 24)
American Journal of Health Sciences     Open Access   (Followers: 6)
American Journal of Health Studies     Full-text available via subscription   (Followers: 11)
American Journal of Preventive Medicine     Hybrid Journal   (Followers: 26)
American Journal of Public Health     Full-text available via subscription   (Followers: 240)
American Journal of Public Health Research     Open Access   (Followers: 29)
American Medical Writers Association Journal     Full-text available via subscription   (Followers: 2)
Analytic Methods in Accident Research     Hybrid Journal   (Followers: 4)
Annals of Global Health     Open Access   (Followers: 9)
Annals of Health Law     Open Access   (Followers: 3)
Annals of Tropical Medicine and Public Health     Open Access   (Followers: 15)
Applied Biosafety     Hybrid Journal  
Applied Research In Health And Social Sciences : Interface And Interaction     Open Access   (Followers: 2)
Archive of Community Health     Open Access  
Archives of Medicine and Health Sciences     Open Access   (Followers: 3)
Arquivos de Ciências da Saúde     Open Access  
Asia Pacific Journal of Counselling and Psychotherapy     Hybrid Journal   (Followers: 8)
Asia Pacific Journal of Health Management     Full-text available via subscription   (Followers: 3)
Asia-Pacific Journal of Public Health     Hybrid Journal   (Followers: 8)
Asian Journal of Gambling Issues and Public Health     Open Access   (Followers: 3)
Association of Schools of Allied Health Professions     Full-text available via subscription   (Followers: 6)
Atención Primaria     Open Access   (Followers: 1)
Australasian Journal of Paramedicine     Open Access   (Followers: 3)
Australian Advanced Aesthetics     Full-text available via subscription   (Followers: 4)
Australian Family Physician     Full-text available via subscription   (Followers: 3)
Australian Indigenous HealthBulletin     Free   (Followers: 6)
Autism & Developmental Language Impairments     Open Access   (Followers: 6)
Behavioral Healthcare     Full-text available via subscription   (Followers: 6)
Best Practices in Mental Health     Full-text available via subscription   (Followers: 8)
Bijzijn     Hybrid Journal   (Followers: 2)
Bijzijn XL     Hybrid Journal   (Followers: 1)
Biomedical Safety & Standards     Full-text available via subscription   (Followers: 8)
BLDE University Journal of Health Sciences     Open Access  
BMC Oral Health     Open Access   (Followers: 5)
BMC Pregnancy and Childbirth     Open Access   (Followers: 20)
BMJ Simulation & Technology Enhanced Learning     Full-text available via subscription   (Followers: 8)
Brazilian Journal of Medicine and Human Health     Open Access  
Buletin Penelitian Kesehatan     Open Access   (Followers: 2)
Buletin Penelitian Sistem Kesehatan     Open Access  
Bulletin of the World Health Organization     Open Access   (Followers: 17)
Cadernos de Educação, Saúde e Fisioterapia     Open Access   (Followers: 1)
Cadernos Saúde Coletiva     Open Access   (Followers: 1)
Canadian Family Physician     Partially Free   (Followers: 12)
Canadian Journal of Community Mental Health     Full-text available via subscription   (Followers: 12)
Canadian Journal of Human Sexuality     Hybrid Journal   (Followers: 1)
Canadian Journal of Public Health     Full-text available via subscription   (Followers: 20)
Case Reports in Women's Health     Open Access   (Followers: 3)
Case Studies in Fire Safety     Open Access   (Followers: 13)
Central Asian Journal of Global Health     Open Access   (Followers: 2)
Central European Journal of Public Health     Full-text available via subscription   (Followers: 4)
CES Medicina     Open Access  
Child Abuse Research in South Africa     Full-text available via subscription   (Followers: 1)
Child's Nervous System     Hybrid Journal  
Childhood Obesity and Nutrition     Open Access   (Followers: 10)
Children     Open Access   (Followers: 2)
CHRISMED Journal of Health and Research     Open Access  
Christian Journal for Global Health     Open Access  
Ciência & Saúde Coletiva     Open Access   (Followers: 2)
Ciencia y Cuidado     Open Access   (Followers: 1)
Ciencia, Tecnología y Salud     Open Access  
ClinicoEconomics and Outcomes Research     Open Access   (Followers: 2)
CME     Hybrid Journal   (Followers: 1)
CoDAS     Open Access  
Community Health     Open Access   (Followers: 2)
Conflict and Health     Open Access   (Followers: 8)
Contraception and Reproductive Medicine     Open Access  
Curare     Open Access  
Current Opinion in Behavioral Sciences     Hybrid Journal   (Followers: 3)
Day Surgery Australia     Full-text available via subscription   (Followers: 2)
Digital Health     Open Access   (Followers: 3)
Dramatherapy     Hybrid Journal   (Followers: 2)
Drogues, santé et société     Full-text available via subscription  
Duazary     Open Access   (Followers: 1)
Early Childhood Research Quarterly     Hybrid Journal   (Followers: 16)
East African Journal of Public Health     Full-text available via subscription   (Followers: 3)
Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity     Hybrid Journal   (Followers: 18)
EcoHealth     Hybrid Journal   (Followers: 4)
Education for Health     Open Access   (Followers: 5)
electronic Journal of Health Informatics     Open Access   (Followers: 6)
ElectronicHealthcare     Full-text available via subscription   (Followers: 4)
Elsevier Ergonomics Book Series     Full-text available via subscription   (Followers: 5)
Emergency Services SA     Full-text available via subscription   (Followers: 2)
Ensaios e Ciência: Ciências Biológicas, Agrárias e da Saúde     Open Access  
Environmental Disease     Open Access   (Followers: 2)
Environmental Sciences Europe     Open Access   (Followers: 2)
Epidemics     Open Access   (Followers: 4)
Epidemiologic Perspectives & Innovations     Open Access   (Followers: 5)
Epidemiology, Biostatistics and Public Health     Open Access   (Followers: 19)
Ethics, Medicine and Public Health     Full-text available via subscription   (Followers: 3)
Ethiopian Journal of Health Development     Open Access   (Followers: 8)
Ethiopian Journal of Health Sciences     Open Access   (Followers: 7)
Ethnicity & Health     Hybrid Journal   (Followers: 13)
European Journal of Investigation in Health, Psychology and Education     Open Access   (Followers: 2)
European Medical, Health and Pharmaceutical Journal     Open Access  
Evaluation & the Health Professions     Hybrid Journal   (Followers: 10)
Evidence-based Medicine & Public Health     Open Access   (Followers: 6)
Evidência - Ciência e Biotecnologia - Interdisciplinar     Open Access  
Expressa Extensão     Open Access  
Face à face     Open Access   (Followers: 1)
Families, Systems, & Health     Full-text available via subscription   (Followers: 8)
Family & Community Health     Partially Free   (Followers: 12)
Family Medicine and Community Health     Open Access   (Followers: 6)
Family Relations     Partially Free   (Followers: 11)
Fatigue : Biomedicine, Health & Behavior     Hybrid Journal   (Followers: 2)
Food and Public Health     Open Access   (Followers: 11)
Frontiers in Public Health     Open Access   (Followers: 7)
Gaceta Sanitaria     Open Access   (Followers: 3)
Galen Medical Journal     Open Access  
Geospatial Health     Open Access  
Gesundheitsökonomie & Qualitätsmanagement     Hybrid Journal   (Followers: 9)
Giornale Italiano di Health Technology Assessment     Full-text available via subscription  
Global Health : Science and Practice     Open Access   (Followers: 5)
Global Health Promotion     Hybrid Journal   (Followers: 16)
Global Journal of Health Science     Open Access   (Followers: 9)
Global Journal of Public Health     Open Access   (Followers: 12)
Global Medical & Health Communication     Open Access   (Followers: 1)
Global Security : Health, Science and Policy     Open Access  
Globalization and Health     Open Access   (Followers: 5)
Hacia la Promoción de la Salud     Open Access  
Hastings Center Report     Hybrid Journal   (Followers: 3)
HEADline     Hybrid Journal  
Health & Place     Hybrid Journal   (Followers: 16)
Health & Justice     Open Access   (Followers: 5)
Health : An Interdisciplinary Journal for the Social Study of Health, Illness and Medicine     Hybrid Journal   (Followers: 7)
Health and Human Rights     Free   (Followers: 9)
Health and Social Care Chaplaincy     Hybrid Journal   (Followers: 7)
Health and Social Work     Hybrid Journal   (Followers: 55)
Health Behavior and Policy Review     Full-text available via subscription   (Followers: 2)
Health Care Analysis     Hybrid Journal   (Followers: 14)
Health Inform     Full-text available via subscription  
Health Information Management Journal     Hybrid Journal   (Followers: 16)
Health Issues     Full-text available via subscription   (Followers: 2)
Health Notions     Open Access  
Health Policy     Hybrid Journal   (Followers: 41)
Health Policy and Technology     Hybrid Journal   (Followers: 3)
Health Professional Student Journal     Open Access   (Followers: 2)
Health Promotion International     Hybrid Journal   (Followers: 21)
Health Promotion Journal of Australia : Official Journal of Australian Association of Health Promotion Professionals     Full-text available via subscription   (Followers: 10)
Health Promotion Practice     Hybrid Journal   (Followers: 15)
Health Prospect     Open Access   (Followers: 1)
Health Psychology     Full-text available via subscription   (Followers: 49)
Health Psychology Research     Open Access   (Followers: 19)
Health Psychology Review     Hybrid Journal   (Followers: 41)
Health Renaissance     Open Access  
Health Research Policy and Systems     Open Access   (Followers: 12)
Health SA Gesondheid     Open Access   (Followers: 2)
Health Science Reports     Open Access  
Health Sciences and Disease     Open Access   (Followers: 2)
Health Services Insights     Open Access   (Followers: 2)
Health Systems     Hybrid Journal   (Followers: 3)
Health Voices     Full-text available via subscription  
Health, Culture and Society     Open Access   (Followers: 13)
Health, Risk & Society     Hybrid Journal   (Followers: 11)
Healthcare     Open Access   (Followers: 1)
Healthcare in Low-resource Settings     Open Access   (Followers: 1)
Healthcare Quarterly     Full-text available via subscription   (Followers: 9)
Healthy-Mu Journal     Open Access  
HERD : Health Environments Research & Design Journal     Full-text available via subscription  
Highland Medical Research Journal     Full-text available via subscription  
Hispanic Health Care International     Full-text available via subscription  
HIV & AIDS Review     Full-text available via subscription   (Followers: 11)
Home Health Care Services Quarterly     Hybrid Journal   (Followers: 6)
Hong Kong Journal of Social Work, The     Hybrid Journal   (Followers: 2)
Hospitals & Health Networks     Free   (Followers: 4)
IEEE Journal of Translational Engineering in Health and Medicine     Open Access   (Followers: 3)
IMTU Medical Journal     Full-text available via subscription  
Indian Journal of Health Sciences     Open Access   (Followers: 2)
Indonesian Journal for Health Sciences     Open Access   (Followers: 1)
Inmanencia. Revista del Hospital Interzonal General de Agudos (HIGA) Eva Perón     Open Access  
Innovative Journal of Medical and Health Sciences     Open Access  
Institute for Security Studies Papers     Full-text available via subscription   (Followers: 5)
interactive Journal of Medical Research     Open Access  
International Health     Hybrid Journal   (Followers: 5)
International Journal for Equity in Health     Open Access   (Followers: 7)
International Journal for Quality in Health Care     Hybrid Journal   (Followers: 34)
International Journal of Applied Behavioral Sciences     Open Access   (Followers: 2)
International Journal of Behavioural and Healthcare Research     Hybrid Journal   (Followers: 8)
International Journal of Circumpolar Health     Open Access   (Followers: 1)
International Journal of Community Medicine and Public Health     Open Access   (Followers: 5)
International Journal of E-Health and Medical Communications     Full-text available via subscription   (Followers: 2)
International Journal of Environmental Research and Public Health     Open Access   (Followers: 20)
International Journal of Evidence-Based Healthcare     Hybrid Journal   (Followers: 8)
International Journal of Food Safety, Nutrition and Public Health     Hybrid Journal   (Followers: 16)
International Journal of Health & Allied Sciences     Open Access   (Followers: 3)

        1 2 3 | Last

Journal Cover Galen Medical Journal
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   ISSN (Print) 2228-5423 - ISSN (Online) 2322-2379
   Published by Shiraz University Homepage  [14 journals]
  • Medical Ethics According to Avicenna's Stance: A Synopsis

    • Authors: Mojtaba Heydari, Sajad Azmand
      Abstract: Medical ethics has been contemplated upon by practitioners since ancient times. Avicenna's notes on medical ethics are presented in the third chapter of the manuscript “Fi Bayan al-hajat Ela al-Teb va al-Atteba va Vasayahom” [meaning: “on needs to medicine and physicians and their recommendations”]by Qutb al-Din Shirazi’s (1236-1311 CE) , one of the main commentators on Avicenna Canon of Medicine. Avicenna refers to several ethical subjects which can be expressed in three main domains: considering patient interests, communication skills, and adhering to the characteristics of professional excellence. Although there are similarities between the classical medical ethics recommendations and ethics recommendations raised by Avicenna, significant moral differences can be considered between the two views, especially in the field of ideology. These differences sometimes lead to difference or even to conflicts in the ethical recommendations.
      PubDate: 2017-12-29
      Issue No: Vol. 6, No. 4 (2017)
       
  • Plant-Based Recombinant Vaccine: Fact or Fiction'

    • Authors: Amir Ghaffar Shahriari, Maziar Habibi-Pirkoohi
      Abstract:  In the era of recombinant DNA technology, production of recombinant vaccines in green plants has emerged as an effective approach addressing the problems of traditional vaccine production. Various antigens expressed in different plant species have been so far tested for the production of efficient oral vaccines against human and livestock diseases. However, recombinant vaccines have not yet found a prominent place in pharmaceutical market. There are still many challenges to be addressed to pave the road for commercial production of plant-based recombinant vaccines. Regarding increasing growth in laboratory studies and field trials for development of plant-based vaccines, this review paper provides a comprehensive overview on the topic of plant-derived vaccines and related issues. [GMJ.2017;In press:In press]

      PubDate: 2017-12-29
      Issue No: Vol. 6, No. 4 (2017)
       
  • A Review of Herbal Medicines for Nausea and Vomiting of Pregnancy in
           Traditional Persian Medicine

    • Authors: Shahrbanoo Abdolhosseini, Fataneh Hashem Dabaghian, Mitra Mehrabani, Roshanak Mokaberinejad
      Abstract: Nausea and vomiting of pregnancy (NVP) is one of the prevalent pregnancy complaints. This study was conducted to review the medicinal plants mentioned in Traditional Persian Medicine (TPM) for the treatment of NVP. A literature research was conducted on a number of main references of TPM, including the books of al-Qanun fī al-Teb, Zakhireye Kharazmshahi, Tadbir-al-Habali al- Atfal al-Sabiban and Makhzan-al-Adviah. Then, medicinal plants mentioned in TPM for treatment of NVP were determined and searched in electronic databases, including PubMed and Google Scholar to find studies that confirmed their efficacy. The search terms were ‘‘vomiting’’ or ‘‘nausea’’ or "emesis" and "pregnancy" and the name of each herb. Data were collected for the years 1990–2016. The findings included 10 plants. Citrus limon (Lemon), Citrus medica L. (Citron), Cydonia oblonga (Quince), Elletaria cardamomum (Cardamom), Mentha spicata L. (Spearmint), Menatha piperita (Mint), Myristica fragrans Houtt (Nutmeg), Pistacia lentiscus Linn. (Mastic), Punica granatum L. (Pomegranate), Malus domestica Borkh (Apple), and Piper cubeba L. are the most recommended medications for NVP. There is evidence in human studies for some of these medicinal plants (Mentha Piperita L., Citrus limon, Elletaria cardamom, and Cydonia oblonga Mill). The other mentioned herbs have not been evaluated during pregnancy. There is limited evidence to safely recommend these plants for NVP. Although some human studies have suggested the antiemetic effects of TPM remedies, their safety is not sufficiently documented in modern literature. Scientific studies on these medicinal plants during pregnancy are warranted to determine their safety. [GMJ.2017;In press:In press]
      PubDate: 2017-12-29
      Issue No: Vol. 6, No. 4 (2017)
       
  • Efficacy and Safety of Iranian Poly Herbal Formulation (Compound Honey
           Syrup) in Pediatric Patients with Mild to Moderate Asthma: A Randomized
           Clinical Trial

    • Authors: Saeed Sadr, Shahpar Kaveh, Rasool Choopani, Houman Bayat, Mahmoud Mosaddegh
      Abstract: Background: Asthma is a chronic relapsing airways disease that represents a major public health problem worldwide. With the high incidence of asthma, there has been a surge in the use of complementary therapies, such as compound honey syrup in Traditional Persian Medicine, in the treatment of asthma. The aim of this study was to evaluate the efficacy and safety of Iranian poly herbal formulation (compound honey syrup) in the treatment of mild to moderate pediatric asthma. Materials and Methods: The study was a randomized clinical trial that was conducted on 80 patients with mild to moderate asthma assigned to two groups (n=40 for each group) for eight weeks. Control and experimental groups received classical treatment of asthma with fluticasone spray; in case of worsening of symptoms, salbutamol spray was used for short term. The experimental group also received compound honey syrup (the combination of honey and an extract of the following five medicinal plants: ginger, cinnamon, saffron, cardamom, and galangal). Asthma Control Questionnaire (ACQ) items and total scores of ACQ were evaluated before and after treatment. Results: To this end, 72 patients completed this study. There was no significant difference between the experimental and the control groups in baseline data such as age, sex, body mass index, ACQ items, and ACQ scores. Total scores and all items of ACQ, with the exception of forced expiratory volume in one second (FEV1%), were significant between groups (P<0.05). No serious adverse effects were observed in the two groups. Conclusions: The results of this study reveal that compound honey syrup can be a safe and effective complementary drug for the treatment of pediatric asthma. [GMJ.2017;In press:In press]
      PubDate: 2017-12-29
      Issue No: Vol. 6, No. 4 (2017)
       
  • The Development and Validation of Sexual Health Education Needs Assessment
           Questionnaire of Iranian Engaged couples

    • Authors: zahra Bostani khalesi, Masoumeh Simbar, Seyed Ali Azin
      Abstract: Background: Knowledge about sexual health is one of the basic needs of young couples. The present study aimed to develop and validate the Sexual Health Education Needs Assessment Questionnaire (SHENAQ). This study was a sequential exploratory mixed method.Method: In the qualitative phase, In-depth interviews were conducted with 38 engaged and married men and women and 9 key informants. After a literature review, in the quantitative phase, validity properties of the SHENAQ were assessed.Results: Sexual health education needs consists of 4 themes "Suitable content for education ","Characteristics of competent educators", "Appropriate technologies in education" and" Educational convenient features”. The content validity ratio (CVR) and content validity index (CVI) of the instrument were 0.91 and0.83 respectively. SHENAQ was designed with 46 items. The instrument's internal consistency was confirmed by alpha coefficient 0.863 and stability assessment through the test-retest was 0.824.Conclusions: SHENAQ is culturally sensitive with satisfactory validity and reliability and could be used to increase the effectiveness of premarital education.
      PubDate: 2017-12-29
      Issue No: Vol. 6, No. 4 (2017)
       
  • Chicory Aroma Water for Neonatal Jaundice: A Randomized Clinical Trial

    • Authors: Mohsen Manouchehrian, Mehrdad Shakiba, Mamak Shariat, Mohammad Kamalinejad, Mehdi Pasalar, Ali Akbar Jafarian, Mohammad Hassan Lotfi, Naeimeh Keighobady
      Abstract: Background: Although neonatal jaundice occurs in 60% of term infants, very little evidence is available on how to prevent it. Given the ethnomedical use of chicory aroma water (CAW) for the management of jaundice by Iranian pregnant women, this study was intended to evaluate whether the frequent CAW consumption was associated with fewer jaundice symptoms after 40 days.Materials and Methods: A single blind randomized controlled trial was designed to enroll participants from Lolagar Hospital, Tehran, Iran. Pregnant women (n=80) were randomly divided into two groups. The trial group was provided with common diet and an instruction to consume CAW. The control group was maintained on common diet. The proportion of phototherapy and mean value of bilirubin were measured to be compared between the two groups.Results: There was no statistically significant difference in the mean value of bilirubin between those women with frequent CAW consumption as compared with the control. Also, the intake of CAW was not associated with a marked improvement in the need for phototherapy (p > 0.05). Conclusions: The findings of this study highlighted that intakes of CAW by pregnant women failed to ameliorate the neonatal jaundice.
      PubDate: 2017-12-29
      Issue No: Vol. 6, No. 4 (2017)
       
  • The effect of oral administration of Hypericum perforatum on serum glucose
           and lipids, hepatic enzymes and lipid peroxidation in
           streptozotocin-diabetic rats

    • Authors: MohammadHassan Ghosian Moghadam, Iman Ansari, Mehrdad Roghani, Ali Ghanem, Neda Mehdizade
      Abstract: Objective: In this research, the beneficial effects of oral administration of Hypericum perforatum (HP) on serum glucose and lipids, hepatic enzymes and the amount of malondialdehyde in streptozotocin-induced diabetic rats are studied.Materials and Methods: In this experimental study, 32 male rats where randomly divided into 4 groups of control, treatment-control, diabetic and treatment-diabetic. HP was orally administered to treatment groups over a period of 6 weeks. Serum glucose levels, triglyceride, total cholesterol along with HDL and LDL were all evaluated prior to initiation of the treatment, and at 3rd and 6th (last) week of treatment initiation, and in the end of the treatment, malondialdehyde and aminotransferase enzymes of the liver were evaluated.Results: regarding serum glucose levels and body weight measured in the 3rd and 6th week, the treatment-diabetic group didn’t show a significant change compared to the diabetic group, regarding serum total cholesterol and LDL levels, a significant decrease was observed and regarding serum HDL, a significant increase was documented. Furthermore, treating the treatment-diabetic group with HP did not result in any significant decrease in serum triglyceride, malondialdehyde or alanine aminotransferase but, in fact, did cause a significant decrease in aspartate aminotransferase.Conclusions: Oral administration of HP did in fact have a beneficial effect on lowering serum levels of total cholesterol, LDL and the hepatic enzyme aspartate aminotransferase and on raising the levels of HDL in diabetized rats with streptozotocin.
      PubDate: 2017-12-29
      Issue No: Vol. 6, No. 4 (2017)
       
  • Assessment of the Protective Impact of Vitamin E on Sex Hormones and Sperm
           

    • Authors: Hassan Moladoust, Ebrahim Nasiri, Rouhollah Gazor, Tolue Mahdavi, Reza Ghorbani, Mohammad Rostampour
      Abstract: Background: Lifestyle factors including environmental and occupational exposure have a key role in reproductive health status and may impact fertility. Formaldehyde (FA) is a suspected reproductive toxicant, which may cause significant adverse effects on reproductive system. Objectives: This study was aimed at detecting the impact of FA and possible protective role of vitamin E (VE) on male rat reproductive system. Materials and Methods: Thirty-two adult male Wistar rats were randomly divided into 4 groups: control rats, rats treated with vehicle (corn-oil), rats treated with 10 mg/kg/day FA (FAt), and rats treated with FA plus 30 mg/kg/day VE plus vehicle (FAt+VE) groups for 2 weeks. After the treatment, sex hormones were examined by ELISA. More over the count, morphology and motility of sperms, were observed. Results: The sperm count and the percentage of rapid progressive sperms were significantly decreased in rats in FAt group compared with those in the control and vehicle-treated group (p<0.05). VE treatment significantly improved the criteria in FAt+VE group (29.85±8.62 vs. 10.04±4.79 for sperm count and 60.50±5.67 vs. 42.19±8.02 for sperm motility). Moreover, the serum follicle-stimulating hormone (FSH) levels mildly decreased in the formaldehyde exposure group; however, the difference was not statistically significant (p>0.05). Conclusion: The findings of this study revealed that formaldehyde exposure can cause negative impact on sperm parameters and some reproductive hormones in rats and vitamin E can attenuate the deleterious impact of FA on the reproductive system of adult male rats.
      PubDate: 2017-12-29
      Issue No: Vol. 6, No. 4 (2017)
       
  • Expression analysis of miRNAs targeting PIK3CA and AKT1 genes of PI3K
           signaling pathway in breast cancer cells.

    • Authors: Javad Razaviyan, Razie Hadavi, Samira Mohammadi-Yeganeh
      Abstract: Introduction:miRNAs are key gene regulators that are involved in many biological and pathological processes including  breast cancer. Breast cancer is the most common form of malignancies in women and requires new therapies and biomarkers. Different signaling pathway such as PI3K signaling pathway are involved in breast cancer and can be a target for targeted therapies based on miRNAs. Furthermore, the aim of this study was to analyze the expression of bioinformatically predicted miRNAs targeting PIK3CA and AKT1 genes of PI3K cascade in breast cancer.Material and method:Bioinformatic software and tools were applied for prediction of miRNAs which target PIK3CA and AKT1 genes. MCF-7 and MCF-10A were cultured as breast cancer and control cell lines, respectively. RNA extraction, cDNA synthesis, and quantitative real-time PCR were performed. REST 2009® was utilized to analyze the expression of miRNAs and their target genes.Results:The results of our bioinformatic predictions indicated that miR-576-5p, miR-501-3p and miR-3143 can be the first candidate miRNAs targeting PI3K signaling pathway. Data analysis demonstrated that PIK3CA and AKT1 genes were up-regulated while all bioinformatically predicted miRNAs were down-regulated in MCF-7 cell line compared to the normal cells.Discussion:The results of our study demonstrated that PIK3CA and AKT1 can be targeted by miR-567-5p and miR-501-3p, respectively and miR-3143 can target mRNAs of both genes. Since these miRNAs target oncogenes, they can propose for complementary targeted therapies in breast cancer patients.
      PubDate: 2017-12-29
      Issue No: Vol. 6, No. 4 (2017)
       
  • Identifying Factors Affecting the Pharmaceutical Supply Chain Management
           in Iran

    • Authors: Yaser Esmaeillou, Iravan Masoudi Asl, Seyed Jamalleddin Tabibi, Abdol majid Cheraghali
      Abstract: Background:This study has been conducted with the aim to identify factors affecting the management of pharmaceutical supply chain in Iran. Materials and Methods:This study was of a combined(quantity–quality)type. The assessment tool was a Likert scale-based five-option questionnaire. Content validity assessment was obtained at 0.89 according to the CVR, and construct validity was at 0.971 using factor analysis.KMO statistics was very high and indicative of a correlation of scale items.In terms of reliability of assessment in researcher-made tools, the selected items were analysed, and the results obtained showed that the applied scales enjoyed significant reliability.The sample for the survey was100experts in the pharmaceutical system of the country’s Food and Drug Administration, pharmaceutical companies, technical officer of pharmacies and the ministry of health and medical education. They were selected by purposive stratified non-random sampling and snowball methods. The data was analysed by exploratory factor analysis using SPSS and LISREL.Results:The results of the current study indicated a pattern with significant and direct relationship between independent and dependent variables of medicine supply chain management. The most important indicators of medicine supply chain management in order of priority were distribution management with impact factor, IT management, pharmaceutical structure, pharmaceutical structure programming, coordination, enterprise resource planning, logistics management, knowledge management, financial management, globalization, customer relationship management, and medical insurance system. Conclusions:According to the patterning indexes, it can be mentioned that the representative model has had a good fit, and a desirable compliance between a structural model with experimental data and expert opinion has been provided.
      PubDate: 2017-12-29
      Issue No: Vol. 6, No. 4 (2017)
       
  • Cardiac infertility in Persian Medicine: Avicenna’s view

    • Authors: Babak Daneshfard, Amir-Mohammad Jaladat Jaladat, Mohammad Reza Sanaye Sanaye, Behnam Dalfardi
      Abstract: Dear Editor Sexual activity makes up a significant portion of anybody’s life: it plays a crucial role when it comes to having full physical, mental, and psychological health.  This part of life-style has been emphasized as an essential need in Persian Medicine (PM) literature [1]. PM sages –such as Rhazes (865-925 AD)– have discussed different types of sexual disorders in their books, offering their own therapeutic methods [2]. Nevertheless, the recent increasing trend of sexual disorders and related complications e.g., infertility, has posed a serious challenge to the physicians and a growing burden to health care systems.Putting emphasis on having a healthy sex life, PM underlines proper regimen and normal digestive system without which negative consequences on both potency and fertility may occur [3]. Moreover, accomplishment of sexual desire and normal sexual function is conditioned upon the well-being of vital organs i.e., heart, brain, liver, and genital system. Not only in traditional literature but also in current studies the relation between cardiovascular diseases and sexual disorders has been mentioned [4].Avicenna (980-1037 AD) (Figure 1), the great Persian scholar of the Islamic Golden Age, is known as one of the pioneers of modern science of cardiology. He has discussed sexual disorders in the third volume of his masterpiece, Canon of Medicine.In the chapter on “noghsan-e-bah” (sexuality weakness), Avicenna discusses different sexual disorders and their proper remedies. For instance, he goes on to cover erectile dysfunction, mentioning its cardiovascular origin [5]. Avicenna precisely describes the clinical features of impotence/infertility with cardiovascular origin: “…If the decrease in the stamina of intercourse is from a cardiac origin, erection would happen less, and ejaculation may occur in a non-erectile state. The pulse would be soft and weak –body temperature drops under the normal degree…” [6].Avoidance of grief and improving body weakness using meat juice are the basic treating approaches in this case. As for the pharmacotherapy, application of fragrant herbs such as sandalwood, rose, and musk has been emphasized. Apple, lemon balm, and borage drinks are repeated prescriptions of Iranian physicians in this regard. In addition, pearls, amber, coral, silk, cloves, white behen, mastic, valerian, and cinnamon are the most common components that are used in combination forms for treating cardiogenic infertility/impotency [7].Establishing such a link in between cardiac diseases and infertility in PM is not far from the current evidence. For instance, it has been revealed that serum testosterone level is significantly decreased in men with chronic heart failure [8]; this could inevitably pose negative effects on fertility. On the other hand, some clinical evidences have shown that using a formulation (Loboob) which increases the cardiac [and other vital organs’] stamina is effective in treatment of infertility [9]. In addition, at least some –if not all– of the medicinal plants used for managing sperm abnormalities in PM have cardiotonic properties [10]. With this regard, we suggest more rigorous investigations to well understand the concept of cardiac infertility and its underlying mechanisms.
      PubDate: 2017-12-29
      Issue No: Vol. 6, No. 4 (2017)
       
 
 
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