Subjects -> HEALTH AND SAFETY (Total: 1508 journals)
    - CIVIL DEFENSE (22 journals)
    - DRUG ABUSE AND ALCOHOLISM (86 journals)
    - HEALTH AND SAFETY (704 journals)
    - HEALTH FACILITIES AND ADMINISTRATION (385 journals)
    - OCCUPATIONAL HEALTH AND SAFETY (106 journals)
    - PHYSICAL FITNESS AND HYGIENE (123 journals)
    - WOMEN'S HEALTH (82 journals)

HEALTH AND SAFETY (704 journals)                  1 2 3 4 | Last

Showing 1 - 200 of 203 Journals sorted alphabetically
16 de Abril     Open Access   (Followers: 3)
Acta Informatica Medica     Open Access  
Acta Scientiarum. Health Sciences     Open Access   (Followers: 2)
Adultspan Journal     Hybrid Journal   (Followers: 1)
Advances in Child Development and Behavior     Full-text available via subscription   (Followers: 11)
Advances in Public Health     Open Access   (Followers: 27)
Adversity and Resilience Science : Journal of Research and Practice     Hybrid Journal   (Followers: 1)
African Health Sciences     Open Access   (Followers: 4)
African Journal for Physical, Health Education, Recreation and Dance     Full-text available via subscription   (Followers: 7)
African Journal of Health Professions Education     Open Access   (Followers: 6)
Afrimedic Journal     Open Access   (Followers: 2)
Ageing & Society     Hybrid Journal   (Followers: 43)
Air Quality, Atmosphere & Health     Hybrid Journal   (Followers: 6)
AJOB Empirical Bioethics     Hybrid Journal   (Followers: 3)
Akademika     Open Access  
American Journal of Family Therapy     Hybrid Journal   (Followers: 10)
American Journal of Health Economics     Full-text available via subscription   (Followers: 18)
American Journal of Health Education     Hybrid Journal   (Followers: 34)
American Journal of Health Promotion     Hybrid Journal   (Followers: 34)
American Journal of Health Sciences     Open Access   (Followers: 10)
American Journal of Health Studies     Full-text available via subscription   (Followers: 13)
American Journal of Preventive Medicine     Hybrid Journal   (Followers: 29)
American Journal of Public Health     Full-text available via subscription   (Followers: 264)
American Journal of Public Health Research     Open Access   (Followers: 27)
American Medical Writers Association Journal     Full-text available via subscription   (Followers: 6)
Analytic Methods in Accident Research     Hybrid Journal   (Followers: 6)
Annales des Sciences de la Santé     Open Access  
Annali dell'Istituto Superiore di Sanità     Open Access  
Annals of Global Health     Open Access   (Followers: 12)
Annals of Health Law     Open Access   (Followers: 6)
Annals of Tropical Medicine and Public Health     Open Access   (Followers: 14)
Applied Biosafety     Hybrid Journal   (Followers: 1)
Applied Research In Health And Social Sciences: Interface And Interaction     Open Access   (Followers: 4)
Apuntes Universitarios     Open Access   (Followers: 1)
Archive of Community Health     Open Access   (Followers: 1)
Archives of Community Medicine and Public Health     Open Access   (Followers: 1)
Archives of Medicine and Health Sciences     Open Access   (Followers: 4)
Archives of Suicide Research     Hybrid Journal   (Followers: 7)
Archivos de Prevención de Riesgos Laborales     Open Access   (Followers: 1)
Arquivos de Ciências da Saúde     Open Access  
Asia Pacific Journal of Counselling and Psychotherapy     Hybrid Journal   (Followers: 10)
Asia Pacific Journal of Health Management     Full-text available via subscription   (Followers: 4)
Asia-Pacific Journal of Public Health     Hybrid Journal   (Followers: 11)
Asian Journal of Gambling Issues and Public Health     Open Access   (Followers: 4)
Asian Journal of Medicine and Health     Open Access   (Followers: 1)
Atención Primaria     Open Access   (Followers: 2)
Atención Primaria Práctica     Open Access   (Followers: 1)
Australasian Journal of Paramedicine     Open Access   (Followers: 5)
Australian Advanced Aesthetics     Full-text available via subscription   (Followers: 4)
Australian Family Physician     Full-text available via subscription   (Followers: 3)
Australian Indigenous HealthBulletin     Free   (Followers: 6)
Autism & Developmental Language Impairments     Open Access   (Followers: 12)
Behavioral Healthcare     Full-text available via subscription   (Followers: 8)
Bijzijn     Hybrid Journal   (Followers: 1)
Bijzijn XL     Hybrid Journal  
Biomedical Safety & Standards     Full-text available via subscription   (Followers: 8)
Biosalud     Open Access   (Followers: 1)
Birat Journal of Health Sciences     Open Access  
BLDE University Journal of Health Sciences     Open Access  
BMC Oral Health     Open Access   (Followers: 7)
BMC Pregnancy and Childbirth     Open Access   (Followers: 22)
BMJ Simulation & Technology Enhanced Learning     Hybrid Journal   (Followers: 12)
Boletin Médico de Postgrado     Open Access  
Brazilian Journal of Medicine and Human Health     Open Access  
British Journal of Health Psychology     Hybrid Journal   (Followers: 49)
Buletin Penelitian Kesehatan     Open Access   (Followers: 2)
Buletin Penelitian Sistem Kesehatan     Open Access  
Bulletin of the World Health Organization     Open Access   (Followers: 21)
Cadernos de Educação, Saúde e Fisioterapia     Open Access   (Followers: 1)
Cadernos de Saúde     Open Access  
Cadernos Saúde Coletiva     Open Access   (Followers: 1)
Cambridge Quarterly of Healthcare Ethics     Hybrid Journal   (Followers: 12)
Canadian Family Physician     Partially Free   (Followers: 13)
Canadian Journal of Community Mental Health     Full-text available via subscription   (Followers: 11)
Canadian Journal of Human Sexuality     Hybrid Journal   (Followers: 2)
Canadian Journal of Public Health     Hybrid Journal   (Followers: 23)
Cannabis and Cannabinoid Research     Hybrid Journal   (Followers: 1)
Carta Comunitaria     Open Access  
Case Reports in Women's Health     Open Access   (Followers: 4)
Case Studies in Fire Safety     Open Access   (Followers: 23)
CASUS : Revista de Investigación y Casos en Salud     Open Access   (Followers: 1)
Central Asian Journal of Global Health     Open Access   (Followers: 2)
CES Medicina     Open Access  
CES Salud Pública     Open Access   (Followers: 1)
Child Abuse Research in South Africa     Full-text available via subscription   (Followers: 1)
Child's Nervous System     Hybrid Journal  
Childhood Obesity and Nutrition     Open Access   (Followers: 11)
Children     Open Access   (Followers: 2)
CHRISMED Journal of Health and Research     Open Access   (Followers: 2)
Christian Journal for Global Health     Open Access  
Ciência & Saúde Coletiva     Open Access   (Followers: 2)
Ciencia & Salud     Open Access  
Ciencia & Trabajo     Open Access   (Followers: 1)
Ciencia e Innovación en Salud     Open Access  
Ciencia y Cuidado     Open Access   (Followers: 1)
Ciencia y Salud     Open Access   (Followers: 3)
Ciencia y Salud Virtual     Open Access  
Ciencia, Tecnología y Salud     Open Access   (Followers: 2)
Cities & Health     Hybrid Journal   (Followers: 2)
Clinical and Experimental Health Sciences     Open Access   (Followers: 1)
ClinicoEconomics and Outcomes Research     Open Access   (Followers: 2)
Clocks & Sleep     Open Access   (Followers: 2)
CME     Hybrid Journal   (Followers: 2)
CoDAS     Open Access  
Community Health     Open Access   (Followers: 5)
Conflict and Health     Open Access   (Followers: 8)
Contraception and Reproductive Medicine     Open Access   (Followers: 2)
Cuaderno de investigaciones: semilleros andina     Open Access   (Followers: 2)
Cuadernos de la Escuela de Salud Pública     Open Access  
Curare     Open Access  
Current Opinion in Behavioral Sciences     Hybrid Journal   (Followers: 10)
Current Opinion in Environmental Science & Health     Hybrid Journal   (Followers: 1)
Day Surgery Australia     Full-text available via subscription   (Followers: 2)
Design for Health     Hybrid Journal  
Digital Health     Open Access   (Followers: 5)
Disaster Medicine and Public Health Preparedness     Hybrid Journal   (Followers: 15)
Diversity and Equality in Health and Care     Open Access   (Followers: 9)
Diversity of Research in Health Journal     Open Access  
Dramatherapy     Hybrid Journal   (Followers: 3)
Drogues, santé et société     Open Access   (Followers: 2)
Duazary     Open Access   (Followers: 1)
Düzce Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi / Journal of Duzce University Health Sciences Institute     Open Access  
Early Childhood Research Quarterly     Hybrid Journal   (Followers: 23)
East African Journal of Public Health     Full-text available via subscription   (Followers: 4)
Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity     Hybrid Journal   (Followers: 22)
EcoHealth     Hybrid Journal   (Followers: 5)
Education for Health     Open Access   (Followers: 8)
electronic Journal of Health Informatics     Open Access   (Followers: 6)
ElectronicHealthcare     Full-text available via subscription   (Followers: 3)
Elsevier Ergonomics Book Series     Full-text available via subscription   (Followers: 5)
Emergency Services SA     Full-text available via subscription   (Followers: 2)
Ensaios e Ciência : Ciências Biológicas, Agrárias e da Saúde     Open Access  
Environmental Disease     Open Access   (Followers: 4)
Environmental Sciences Europe     Open Access   (Followers: 2)
Epidemics     Open Access   (Followers: 5)
Epidemiologic Perspectives & Innovations     Open Access   (Followers: 6)
Epidemiology, Biostatistics and Public Health     Open Access   (Followers: 20)
EsSEX : Revista Científica     Open Access   (Followers: 1)
Estudios sociales : Revista de alimentación contemporánea y desarrollo regional     Open Access   (Followers: 1)
Ethics & Human Research     Hybrid Journal   (Followers: 3)
Ethics, Medicine and Public Health     Full-text available via subscription   (Followers: 6)
Ethiopian Journal of Health Development     Open Access   (Followers: 7)
Ethiopian Journal of Health Sciences     Open Access   (Followers: 8)
Ethnicity & Health     Hybrid Journal   (Followers: 14)
Eurasian Journal of Health Technology Assessment     Open Access  
EUREKA : Health Sciences     Open Access   (Followers: 2)
European Journal of Investigation in Health, Psychology and Education     Open Access   (Followers: 4)
European Medical, Health and Pharmaceutical Journal     Open Access   (Followers: 1)
Evaluation & the Health Professions     Hybrid Journal   (Followers: 10)
Evidence-based Medicine & Public Health     Open Access   (Followers: 9)
Evidência - Ciência e Biotecnologia - Interdisciplinar     Open Access  
Expressa Extensão     Open Access  
Face à face     Open Access   (Followers: 1)
Families, Systems, & Health     Full-text available via subscription   (Followers: 9)
Family & Community Health     Hybrid Journal   (Followers: 14)
Family Medicine and Community Health     Open Access   (Followers: 10)
Family Relations     Partially Free   (Followers: 14)
Fatigue : Biomedicine, Health & Behavior     Hybrid Journal   (Followers: 2)
Finnish Journal of eHealth and eWelfare : Finjehew     Open Access  
Food and Public Health     Open Access   (Followers: 17)
Food Quality and Safety     Open Access   (Followers: 1)
Frontiers in Digital Health     Open Access  
Frontiers in Public Health     Open Access   (Followers: 8)
Frontiers of Health Services Management     Partially Free   (Followers: 2)
Gaceta Sanitaria     Open Access   (Followers: 3)
Galen Medical Journal     Open Access   (Followers: 1)
Ganesha Journal     Open Access  
Gazi Sağlık Bilimleri Dergisi     Open Access  
Geospatial Health     Open Access  
Gestão e Desenvolvimento     Open Access  
Gesundheitsökonomie & Qualitätsmanagement     Hybrid Journal   (Followers: 9)
Giornale Italiano di Health Technology Assessment     Full-text available via subscription  
Global Advances in Health and Medicine     Open Access  
Global Challenges     Open Access  
Global Health : Science and Practice     Open Access   (Followers: 7)
Global Health Journal     Open Access   (Followers: 1)
Global Health Promotion     Hybrid Journal   (Followers: 17)
Global Journal of Health Science     Open Access   (Followers: 10)
Global Journal of Public Health     Open Access   (Followers: 13)
Global Medical & Health Communication     Open Access   (Followers: 2)
Global Mental Health     Open Access   (Followers: 9)
Global Reproductive Health     Open Access  
Global Security : Health, Science and Policy     Open Access   (Followers: 1)
Global Transitions     Open Access   (Followers: 1)
Globalization and Health     Open Access   (Followers: 8)
Hacia la Promoción de la Salud     Open Access  
Hastane Öncesi Dergisi     Open Access  
Hastings Center Report     Hybrid Journal   (Followers: 4)
HCU Journal     Open Access  
HEADline     Hybrid Journal  
Health & Place     Hybrid Journal   (Followers: 19)
Health & Justice     Open Access   (Followers: 6)
Health : An Interdisciplinary Journal for the Social Study of Health, Illness and Medicine     Hybrid Journal   (Followers: 13)
Health and Human Rights     Open Access   (Followers: 10)
Health and Social Care Chaplaincy     Hybrid Journal   (Followers: 10)
Health and Social Work     Hybrid Journal   (Followers: 69)
Health Behavior and Policy Review     Full-text available via subscription   (Followers: 3)
Health Care Analysis     Hybrid Journal   (Followers: 16)
Health Equity     Open Access  
Health Inform     Full-text available via subscription  

        1 2 3 4 | Last

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CES Medicina
Number of Followers: 0  

  This is an Open Access Journal Open Access journal
ISSN (Print) 0120-8705 - ISSN (Online) 2215-9177
Published by SciELO Homepage  [912 journals]
  • Nueva clasificación en Publindex y Redalyc

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  • Evaluation of the bone marrow in cytopenic patients infected with human
           immunodeficiency virus type 1 in a third level Colombian hospital

    • Abstract: Resumen Objetivo: describir los hallazgos en el estudio de medula ósea de los pacientes con infección por virus de inmunodeficiencia humana que presentaron algún tipo de citopenia. Materiales y métodos: estudio descriptivo retrospectivo con 37 pacientes adultos con infección confirmada por el virus de inmuno deficiencia humana que presentaron algún tipo de citopenia, durante enero 2011 a diciembre de 2014 en el Hospital Universitario Hernando Moncaleano Perdomo de Neiva. Resultados: la mediana de edad fue 35 años, el 59 % fueron hombres; en el 48,6 % el tiempo de diagnóstico de la infección fue inferior a un año y el 59 % no recibían terapia antiretroviral al momento de ingreso. La mediana de recuento leucocitario de 2 400 células/mm3, neutró filos de 1 400 células/mm3 y de linfocitos CD4 de 43 células/mm3. El estudio de medula ósea fue positivo en el 27 %, encontrando infección oportunista diseminada en seis pacientes; dos con neoplasias, además de uno con hipo plasia medular y otro con anemia megaloblástica. Conclusión: el estudio de medula ósea en los pacientes con infección por virus de inmunodeficiencia humana es una herramienta útil y se debe realizar a todos los pacientes con enfermedad avanzada en el estudio de citopenia asociada o no a fiebre.Abstract Objective: To describe the findings in the study of bone marrow of patients with human immunodeficiency virus (HIV) infection who present some type of cytopenia in a highly complex hospital in southern Colombia. Materials and methods: Retrospective descriptive study of case series. All adult pa tients with confirmed HIV infection who presented some type of cytopenia during January 2011 to December 2014 at the University Hospital Hernando Moncaleano Perdomo de Neiva, were included. A total of 37 patients com pleted the inclusion criteria. Results: the median age was 35 years, 59 % men; in 48.6 % of the individuals, the time of diagnosis by HIV was less than one year and 59 % did not receive antiretroviral therapy at the time of admission. A median was found in a leukocyte count of 2400 cells / mm3, neutrophils of 1400 cells / mm3, CD4 lymphocytes of 43 cells / mm3. The bone marrow study was positive in 27 % of the cases (10 patients), finding disseminated opportunistic infection in six patients; two neoplasms, plus a medullar hypoplasia and a case of megaloblastic anemia. Conclusion: The study of bone marrow in patients with HIV infection is a useful tool and should be performed in all patients with HIV infection with advanced disease in the study of cytopenia associated or not with fever.
       
  • Natural infection of Aedes aegypti, Ae. albopictus and Culex spp. with
           Zika virus in Medellin, Colombia

    • Abstract: Abstract Introduction: The Zika virus has generated serious epidemics in the different countries where it has been reported and Colombia has not been the exception. Although in these epidemics Aedes aegypti traditionally has been the primary vector, other species could also be involved in the transmission. Methods: Mosquitoes were captured with entomological aspirators on a monthly ba sis between March and September of 2017, in four houses around each of the 250 entomological surveillance traps installed by the Secretaria de Sa lud de Medellin (Colombia). Additionally, 70 Educational Institutions and 30 Health Centers were visited each month. Results: 2 504 mosquitoes were captured and grouped into 1045 pools to be analyzed by RT-PCR for the detection of Zika virus. Twenty-six pools of Aedes aegypti, two pools of Ae. albopictus and one for Culex quinquefasciatus were positive for Zika virus. Conclusion: The presence of this virus in the three species and the abundance of these species in the different sectors of the city, suggests that the control strategies should be addressed to all species that could be potential vec tors until the vectorial role of Ae. albopictus and Culex quinquefasciatus is completely elucidated in the transmission of the Zika virus.Resumen Introducción: El virus Zika ha generado serias epidemias en los diferentes países en donde se ha reportado, Colombia no ha sido la excepción. Aunque en estas epidemias el vector presuntamente involucrado ha sido Aedes aegypti, otras especies también podrían estar implicadas en su transmisión. Meto dología: en el marco del Programa de vigilancia virológica en mosquitos de la Secretaría de Salud de Medellín (Colombia). Resultados: entre marzo y septiembre de 2017 se capturaron 2 504 mosquitos en predios visitados durante los levantamientos de índices entomológicos. El material entomo lógico fue agrupado en 1 045 pooles para ser analizados por RT-PCR para la detección de virus Zika. Resultaron positivos para virus Zika 26 pooles de Aedes aegypti, dos pooles de Ae. albopictus y uno para Culex quinquefasciatus. Conclusión: la presencia de este virus en las tres especies y su abundancia en los distintos sectores de la ciudad sugieren que las estrategias de control deban dirigirse a todos los potenciales vectores, hasta tanto no se dilucide comple tamente el papel vectorial de Ae. albopictus y Cx. quinquefasciatus en la transmisión del virus Zika.
       
  • Effects of nervous system injuries on the physiology of urination

    • Abstract: Resumen La disfunción neurogénica del tracto urinario inferior abarca una amplia variedad de trastornos que se caracterizan por una disfunción de la fisio logía de la micción. Muchas veces su diagnóstico no suele ser fácil y suele primero diagnosticarse la disfunción del tracto urinario y posteriormente encontrar el diagnóstico del trastorno neurológico que lo ocasiona. Todos estos trastornos terminan afectando gravemente la calidad de vida de las pacientes, por sus complicaciones propias y las derivadas de la condición. Algunas de estas complicaciones son infecciones urinarias recurrentes, incontinencia urinaria, disfunción del vaciamiento vesical, estenosis uretral y enfermedad renal progresiva con daño irreversible. Los objetivos de esta revisión son exponer las diferentes alteraciones neurológicas según la cla sificación SALE y describir cómo afectan la fisiología de la micción.Abstract Neurogenic dysfunction of the lower urinary tract encompasses a wide variety of disorders, which are characterized by a dysfunction of the urination physiology. In many times the diagnosis of this type of pathologies is usually not so easy, and the urinary tract dysfunc tion can be diagnosed first and secondarily find the diagnosis of the neurological disorder that causes it. All these disorders end up se riously affecting the quality of life of these patients, due to their own complications and the complications derived from the condition. Some of the associated complications are recurrent urinary tract infections, urinary incontinence and bladder emptying dysfunction, urethral stricture and progressive kidney disease with irreversible damage. The location of the neurological lesion does not always de termine the type of inferior urinary dysfunction. The objective of this review is to expose the different neurological alterations according to the SALE classification and describe how they affect the physiol ogy of urination.
       
  • Immunology of leptospirosis

    • Abstract: Resumen Leptospirosis es una enfermedad re-emergente de distribución mundial ocasionada por espiroquetas patogénicas del género Leptospira que afectan humanos, animales domésticos o silvestres. Las manifestaciones clínicas de la enfermedad son diversas y son el resultado de la interacción de la respuesta inmune del hospedador y las condiciones de virulencia propias de las especies patógenas. Aunque se desconocen muchos aspectos de la inmunidad en la infección por Leptospira spp, es reconocido que los hospe deros susceptibles presentan diferencias en su respuesta inmune, como la activación/evasión del sistema del complemento, la activación de sub poblaciones celulares, la producción de citoquina y el desarrollo de anti cuerpos. El estudio del perfil inmunológico en pacientes con leptospirosis ha sido documentado y contribuye en la identificación de biomarcadores asociados con severidad. Esta revisión presenta algunos de los eventos relacionados con la respuesta inmune desde el ingreso de la bacteria en la fase inicial de la infección hasta su multiplicación y generación de enfer medad en el humano.Abstract Leptospirosis is a re-emergent disease of worldwide distribution caused by pathogenic spirochetes of the Leptospira genus that affect humans, do mestic and wild animals. The clinical manifestations of the disease are diverse and are the result of the interaction of the immune response of the host and the virulence conditions of the pathogenic species. Although many aspects of immunity in infection with Leptospira spp are unknown, it is recognized that susceptible hosts show differences in their immune res ponse, such as activation / evasion of the complement system, activation of cellular subpopulations, production of cytokines, development of anti bodies. Study of the immunological profile in patients with leptospirosis has been documented and contributes in the identification of bio-markers associated with severity. This review presents updated events related to the immune response from the entry of the bacteria in the initial phase of the infection to its multiplication and generation of human disease.
       
  • Glucantime and QTc interval prolongation: A fatal combination

    • Abstract: Resumen La leishmaniosis cutánea es una enfermedad causada por un parásito pro tozoo intracelular; el glucantime es una opción terapéutica, aunque está asociado con alteraciones cardiovasculares, siendo la más frecuente la prolongación del intervalo QTc que se presenta entre el 17,8 % y 19 % de los pacientes. Si este efecto no es detectado a tiempo puede causar una arritmia fatal por torsade de pointes. Se presenta el caso de una paciente de 77 años quien se encontraba en tratamiento con glucantime intramus cular como tratamiento de leishmaniosis cutánea e ingresó por un cuadro clínico de hipocalemia severa refractaria y episodios de torsade de pointes; posteriormente, presentó fibrilación ventricular que no respondió a des fibrilación y reanimación. Las alteraciones en la repolarización cardiaca producidas por este medicamento se consideran secundarias a la acu mulación de compuestos pentavalentes y trivalentes en el miocardio. No existe tratamiento específico para esta situación, pero siempre se debe realizar manejo de soporte, evitar fármacos que prolonguen el intervalo QT, normalizar los niveles de potasio y de magnesio, elevar la frecuencia cardiaca con isoproterenol e implantar marcapaso transvenoso para lograr sobre-estimulación y reducción de los periodos refractarios.Abstract Cutaneous leishmaniasis is a disease caused by an intracellular protozoan parasite; Glucantime is a therapeutic option, although it is associated with cardiovascular alterations, the most frequent being the prolongation of the QTc interval, that occurs between 17.8% and 19% of patients. If this effect is not early recognized, it can cause a fatal arrhythmia due to torsade de pointes. The case of a 77-year-old patient who was receiving intramuscu lar glucantime as treatment for cutaneous leishmaniasis is presented, the patient was admitted with severe refractory hypokalemia and episodes of torsade de pointes; subsequently, presented ventricular fibrillation that did not respond to defibrillation and resuscitation. The alterations in cardiac repolarization produced by this medicine are considered secondary to the accumulation of pentavalent and trivalent compounds in the myocardium. There is no specific treatment for this situation, but supportive manage ment should always be performed, avoid drugs that prolong the QT inter val, normalize potassium and magnesium levels, raise the heart rate with isoproterenol and implant transvenous pacemaker to achieve over-stimulation and reduction of refractory periods.
       
  • Opsoclonus-mioclonus-ataxia syndrome associated with a mature ovarian
           teratoma in a pediatric patient

    • Abstract: Resumen El síndrome de opsoclonus-mioclonus-ataxia es una entidad rara que cursa con síntomas motores, neurocognitivos y psiquiátricos, con frecuencia marcadamente debilitantes. El síndrome se reporta con mayor frecuencia en adultos que en niños, la etiología es variada, pero en pediatría se presenta en la mayoría de los casos como un síndrome paraneoplásico. En este contexto la neoplasia más frecuentemente asociada es el neuroblastoma. La evidencia actual apoya la tesis de que este es un síndrome mediado inmunológicamente al haberse identificado una serie de auto-anticuerpos en los pacientes afectados, y a que muchos de ellos responden a terapia inmunosupresora. La importancia del reconocimiento de este síndrome radica en que existe tratamiento médico y quirúrgico que podría mejorar el pronóstico neurológico y psiquiátrico. Presentamos el caso de una paciente que se presentó con este síndrome en nuestra institución.Abstract The opsoclonus-myoclonus-ataxia syndrome is a rare entity that presents with motor, neurocognitive and psychiatric symptoms, often markedly de bilitating. The syndrome is reported more frequently in adults than in chil dren, the etiology is varied, but in pediatrics it occurs in most cases as a paraneoplastic syndrome. In this context, the most frequently associated neoplasm is neuroblastoma followed by gynecological tumors. The current evidence supports the thesis that this is an immune-mediated syndrome because a series of circulating autoantibodies has been described in the affected patients, in addition to many of them responding to immuno suppressive therapy. The importance of recognizing this syndrome is that there is medical/surgical treatment available that could improve the neu rological and psychiatric prognosis. Next, we present the case of a patient who presented with this syndrome in our institution.
       
  • Osteogenesis imperfecta type IV originated in a rare variant of change of
           direction in COL1A2

    • Abstract: Resumen La osteogénesis imperfecta es una rara anomalía genética que se carac teriza por una baja masa ósea y susceptibilidad aumentada a fracturas. La mayoría de los casos se asocian a variantes en los genes COL1A1 y COL1A2 que codifican para el colágeno tipo I. Se ha clasificado en cua tro tipos, siendo el tipo IV el menos frecuente. Se presenta un caso de osteogénesis imperfecta tipo IV en una niña de seis meses, quien tenía escleras azules y acortamiento bilateral del fémur y desviación en varo de la tibia. Las radiografías mostraron desproporción craneofacial y hue sos wormianos, fusión atlanto-odontoidea; luxación coxo-femoral bila teral congénita, acortamiento y desviación del fémur bilateral, fractura antigua en fémur derecho y osteopenia generalizada. Se realizó panel molecular que incluyó los genes ALPL, COL1A1, COL1A2 e IFITM5, mos trando en COL1A2 una transición en heterocigosis de guanina a adenina (c.2531G>A), cambio asociado con osteogénesis imperfecta. El objetivo de este reporte es brindar información sobre la presentación clínica, los métodos diagnósticos y las posibilidades terapéuticas de una rara enfer medad genética.Abstract Osteogenesis imperfecta is a rare genetic anomaly characterized by low bone mass and increased susceptibility to fractures. The majority of cases are associated with variants in the COL1A1 and COL1A2 genes that code for type I collagen. It has been classified into four types, with type IV being the least frequent. We present a case of osteogenesis imperfecta type IV in a six-month-old girl, who had blue scleras and bilateral shortening of the femur and varus deviation of the tibia. X-rays showed craniofacial disproportion and wormian bones, atlanto-odontoid fusion; bilateral congenital bilateral coxo-femoral dislocation, shortening and deviation of the bilateral femur, old fracture in the right femur and generalized osteopenia. A molecular panel was carried out that included the ALPL, COL1A1, COL1A2 and IFITM5 genes, showing in COL1A2 a transition in guanine to adenine heterozygosis (c.2531G>A), a change associated with osteogenesis imperfecta. The objective of this report is to provide information on the clinical presentation, diagnostic methods and therapeutic possibilities of a rare genetic disease.
       
  • Ileotransverse intussusception due to intraluminal lipoma

    • Abstract: Resumen La intususcepción intestinal consiste en la introducción o invaginación de un segmento del intestino dentro de la luz del segmento adyacente. Una parte del intestino se pliega como un telescopio y penetra dentro de otra. La ma yoría de los casos se producen durante los primeros cinco años de vida y la mitad de estos durante el primer año. En los niños mayores y en los adultos frecuentemente es el resultado de lesiones tumorales intraluminales como lipomas, carcinoma, pólipos fibroides inflamatorios o linfoma maligno. Se presenta el caso clínico de una paciente de 45 años con cuadro de dolor ab dominal originado por intususcepción ileotransversa causada por un lipoma intraluminal, el cual fue resuelto exitosamente mediante cirugía.Abstract Intussusception involves the introduction or invagination of a segment of the intestine within the lumen of the adjacent segment. A part of the intes tine folds like a telescope and penetrates into another. Most cases occur during the first five years of life and half of these during the first year. In older children and adults are the result of intraluminal tumor lesions such as lipomas, carcinoma, inflammatory fibroid polyps or malignant lymphoma. We present the clinical case of a 45-year-old patient with abdominal pain caused by ileotransverse intussusception caused by an intraluminal lipoma, which was successfully resolved by surgery.
       
  • Classical extragonadal seminoma in stage III

    • Abstract: Resumen Histológicamente, los tumores testiculares de células germinales pueden clasificarse como tumores de tipo no seminoma y seminoma. De este último se reconocen tres variantes: “anaplásica”, “espermatocítica” y “clásica”, la cual puede ser gonadal o extragonadal. En este subtipo el tumor tiene origen en las células germinales, aunque no inicia en las gónadas sino en otras regiones anatómicas como el mediastino o el retroperitoneo. Presentamos el caso de un paciente de 19 años quien inicialmente presentó un cuadro clínico compatible con síndrome de vena cava superior y trombosis yugular. El diagnóstico de la neoplasia se obtuvo mediante biopsia por toracotomía.Abstract Histologically, germ cell testicular tumors can be classified as nonseminoma and seminoma tumors. Of the latter, three variants are recognized: “ana plastic”, “spermatocytic” and “classical”, which may be gonadal or extrago nadal. In this subtype, the tumor originates in the germ cells, although it does not start in the gonads but in other anatomical regions such as the mediastinum or the retroperitoneum. We present a case of a 19-year-old patient who initially presented clinical sintomatology compatible with su perior vena cava syndrome and jugular thrombosis. The diagnosis of the neoplasm was obtained by thoracotomy biopsy.
       
  • Mediastinal parathyroid adenoma as a cause of primary hyperparathyroidism

    • Abstract: Resumen Las glándulas paratiroides participan en la regulación de las concentraciones de calcio al producir parathormona como respuesta a la hipocalcemia. Los adenomas paratiroideos, que rara vez se encuentran en mediastino, son la causa más importante de hiperparatiroidismo primario, una enfermedad rara con manifestaciones clínicas graves y que se diagnostica por la com binación de concentraciones elevadas de calcio sérico y paratohormona. Se considera que el adenoma paratiroideo ectópico se deriva de la migra ción de las glándulas paratiroides al mediastino y se conoce como una causa importante del fracaso de la exploración primaria del hiperparatiroi dismo primario. Se presenta un caso de adenoma paratiroideo mediastíni co en una mujer de 48 años que llevó a la aparición de hiperparatiroidismo primario. El adenoma se extirpó mediante esternotomía media total.Abstract Parathyroid glands participate in regulation of calcium concentrations by producing parathormone in response to hypocalcemia. Parathyroid adeno mas, which are rarely found in the mediastinum, are the most important cause of primary hyperparathyroidism, which is a rare disease with serious clinical manifestations and is diagnosed by combination of high concentrations of serum calcium and parathormone. It is considered that ectopic parathyroid adenoma is derived from the migration of the parathyroid glands to the mediastinum and is known as an important cause of the failure of primary exploration of primary hyperparathyroidism. We present a case of medias tinal parathyroid adenoma in a 48-year-old woman that led to appearance of primary hyperparathyroidism. Adenoma was removed by total median sternotomy.
       
  • Ophidic accident by Bothrops atrox in a minor of Ucayali, Peru

    • Abstract: Resumen El género Bothrops se encuentra ampliamente distribuido en la Amazonía peruana, siendo el responsable de más del 70 % de los casos de envenena miento por mordedura de serpiente. En el Perú se estima que ocurren 2 150 casos de mordedura de serpiente al año; no obstante, este número podría ser mucho mayor debido a una baja notificación. Se describe el caso de un menor de edad de la zona rural de Ucayali quien había sido mordido por un jergón “Bothrops atrox” y presentaba plaquetopenia, marcado edema cerca de la zona de la mordedura y dificultad para orinar, evolución tórpida a pesar de la terapia implementada y culminando en su deceso. El presente caso pone énfasis en el buen manejo terapéutico y la prontitud de su imple mentación para evitar complicaciones y desenlaces fatales.Abstract The genus Bothorops is widely distributed in the Peruvian Amazon, being responsible for more than 70 % of cases of snake bite poisoning. In Perú it is estimated that 2150 cases of snakebite occur each year; however, this number could be much higher due to low notification. We describe the case of a minor, who reports having been bitten by a “Bothrops” in a rural area in the Ucayali region, with presence of thrombocytopenia, marked edema near the area of the bite and difficulty urinating with a torpid evolution despite the therapy implemented, culminating in the death of the patient. The present case emphasizes good therapeutic management and the promptness of its implementation to avoid complications and other fatal outcomes.
       
 
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