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PATHOLOGY (98 journals)

Showing 1 - 98 of 98 Journals sorted alphabetically
Academic Pathology     Open Access   (Followers: 5)
Acta Neuropathologica Communications     Open Access   (Followers: 1)
Advances in Anatomic Pathology     Hybrid Journal   (Followers: 21)
Advances in Molecular Pathology     Hybrid Journal   (Followers: 1)
Advances in Plant Pathology     Full-text available via subscription   (Followers: 6)
American Journal of Clinical Pathology     Full-text available via subscription   (Followers: 30)
American Journal of Dermatopathology     Hybrid Journal   (Followers: 17)
American Journal of Forensic Medicine and Pathology     Hybrid Journal   (Followers: 29)
American Journal of Pathology     Hybrid Journal   (Followers: 33)
American Journal of Surgical Pathology     Hybrid Journal   (Followers: 38)
Analytical Cellular Pathology     Open Access   (Followers: 3)
Annals of Cytology and Pathology     Open Access   (Followers: 1)
Annals of Diagnostic Pathology     Hybrid Journal   (Followers: 15)
Annals of Oral & Maxillofacial Surgery     Open Access   (Followers: 6)
Annals of Tropical Pathology     Open Access  
Annual Review of Pathology Mechanisms of Disease     Full-text available via subscription   (Followers: 7)
Archives of Pathology & Laboratory Medicine     Full-text available via subscription   (Followers: 31)
Assessment and Treatment of Child Psychopathology and Developmental Disabilities     Full-text available via subscription   (Followers: 4)
Basic and Applied Pathology     Open Access   (Followers: 3)
BMC Clinical Pathology     Open Access   (Followers: 7)
Brain Pathology     Hybrid Journal   (Followers: 5)
Brain Tumor Pathology     Hybrid Journal   (Followers: 6)
Bulletin de la Société de pathologie exotique     Hybrid Journal   (Followers: 1)
Cancer Cytopathology     Partially Free   (Followers: 22)
Cardiovascular Pathology     Hybrid Journal   (Followers: 4)
Case Reports in Pathology     Open Access   (Followers: 7)
Clinical Neuropathology     Full-text available via subscription   (Followers: 1)
Clinical Pathology     Open Access   (Followers: 3)
Comparative Clinical Pathology     Hybrid Journal   (Followers: 3)
Critical Values     Full-text available via subscription  
Cytopathology     Hybrid Journal   (Followers: 12)
Der Pathologe     Hybrid Journal   (Followers: 2)
Dermatopathology     Open Access   (Followers: 3)
Diagnostic Cytopathology     Hybrid Journal   (Followers: 13)
Diagnostic Histopathology     Full-text available via subscription   (Followers: 14)
Diagnostic Pathology     Open Access   (Followers: 13)
Egyptian Journal of Pathology     Partially Free   (Followers: 1)
Endocrine Pathology     Hybrid Journal   (Followers: 4)
Experimental and Molecular Pathology     Hybrid Journal   (Followers: 5)
Experimental and Toxicologic Pathology     Hybrid Journal   (Followers: 10)
Fetal and Pediatric Pathology     Hybrid Journal   (Followers: 4)
Folia Neuropathologica     Open Access  
Forensic Science, Medicine, and Pathology     Hybrid Journal   (Followers: 34)
Head and Neck Pathology     Hybrid Journal   (Followers: 7)
Hepatoma Research     Open Access   (Followers: 2)
Histopathology     Hybrid Journal   (Followers: 28)
Human Pathology     Hybrid Journal   (Followers: 30)
Indian Journal of Pathology and Microbiology     Open Access   (Followers: 3)
Inflammation and Cell Signaling     Open Access   (Followers: 3)
International Journal of Clinical and Experimental Pathology     Open Access   (Followers: 2)
International Journal of Experimental Pathology     Hybrid Journal   (Followers: 1)
International Journal of Gynecological Pathology     Hybrid Journal   (Followers: 9)
International Journal of Ophthalmic Pathology     Hybrid Journal   (Followers: 2)
International Journal of Oral & Maxillofacial Pathology     Open Access   (Followers: 8)
International Journal of Surgical Pathology     Hybrid Journal   (Followers: 9)
Iranian Journal of Pathology     Open Access  
Journal of Clinical & Experimental Pathology     Open Access   (Followers: 3)
Journal of Clinical Pathology     Hybrid Journal   (Followers: 13)
Journal of Clinical Pathology and Forensic Medicine     Open Access   (Followers: 9)
Journal of Comorbidity     Open Access  
Journal of Comparative Pathology     Hybrid Journal   (Followers: 5)
Journal of Cutaneous Pathology     Hybrid Journal   (Followers: 11)
Journal of Depression and Anxiety     Open Access   (Followers: 2)
Journal of Diagnostic Pathology     Open Access   (Followers: 9)
Journal of Hematopathology     Hybrid Journal   (Followers: 5)
Journal of Morphological Sciences     Open Access  
Journal of Neuropathology & Experimental Neurology     Hybrid Journal   (Followers: 1)
Journal of Oral and Maxillofacial Pathology     Open Access   (Followers: 3)
Journal of Oral Pathology & Medicine     Hybrid Journal   (Followers: 5)
Journal of Pathology     Hybrid Journal   (Followers: 13)
Journal of Pathology : Clinical Research     Open Access   (Followers: 1)
Journal of Pathology Informatics     Open Access   (Followers: 2)
Journal of Pathology of Nepal     Open Access   (Followers: 1)
Journal of Physiology and Pathophysiology     Open Access   (Followers: 1)
Modern Pathology     Hybrid Journal   (Followers: 32)
Molecular and Cellular Biomedical Sciences     Open Access   (Followers: 3)
Molecular Diagnosis & Therapy     Hybrid Journal   (Followers: 3)
Neuropathology     Hybrid Journal   (Followers: 1)
Neuropathology and Applied Neurobiology     Hybrid Journal  
Ocular Oncology and Pathology     Full-text available via subscription  
Open Journal of Bacteriology     Open Access   (Followers: 1)
Open Journal of Pathology     Open Access   (Followers: 3)
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology     Full-text available via subscription   (Followers: 9)
Pathogenesis     Open Access  
Pathology     Hybrid Journal   (Followers: 12)
Pathology & Oncology Research     Hybrid Journal   (Followers: 4)
Pathology - Research and Practice     Hybrid Journal   (Followers: 4)
Pathology and Laboratory Medicine International     Open Access   (Followers: 7)
Pathology International     Hybrid Journal   (Followers: 2)
Pathology Research International     Open Access   (Followers: 1)
Pediatric and Developmental Pathology     Hybrid Journal   (Followers: 4)
Revista de Patologia do Tocantins     Open Access  
Revista de Senología y Patología Mamaria     Full-text available via subscription  
Seminars in Diagnostic Pathology     Hybrid Journal   (Followers: 10)
Seminars in Immunopathology     Hybrid Journal   (Followers: 3)
Surgical Pathology Clinics     Full-text available via subscription   (Followers: 9)
Ultrastructural Pathology     Hybrid Journal   (Followers: 1)
Патологія     Open Access  
Similar Journals
Journal Cover
Journal of Hematopathology
Journal Prestige (SJR): 0.26
Number of Followers: 5  
 
  Hybrid Journal Hybrid journal (It can contain Open Access articles)
ISSN (Print) 1868-9256 - ISSN (Online) 1865-5785
Published by Springer-Verlag Homepage  [2626 journals]
  • Therapeutic targets and microenvironment in sequential biopsies of
           classical Hodgkin lymphoma at diagnosis and relapse
    • Abstract: Abstract Classical Hodgkin lymphoma is dominated by the non-neoplastic microenvironment, while the neoplastic Hodgkin-Reed-Sternberg cells compose only a minority of cells in the lymphoma tissue. Both the Hodgkin-Reed-Sternberg cells due to their expression of CD30 and PD-L1 and the microenvironment with abundant T cells and expression of PD1 are specifically targeted by new treatment concepts. We aimed to understand the dynamics of therapeutic targets in patients treated with conventional chemotherapy. We analyzed sequential biopsy specimens obtained at diagnosis and at relapse from the same patient for morphology, immunophenotype, and microenvironmental components. The morphological subtype changed between primary and relapse biopsy in 20% of cases. The immunophenotype was stable with respect to CD30, CD3, and LMP1 but variable with respect to CD15 and CD20 expression. Gene expression revealed 8 upregulated and 20 downregulated genes at relapse (p ≤ 0.05) with a consistent logarithmic fold change direction in at least 75% of all cases. For PD1, we found discrepant results between gene expression analysis (decrease at relapse) and number of PD1-positive cells assessed by immunohistochemistry (unchanged at relapse). PD-L1 in the neoplastic cells appeared unchanged between primary diagnosis and relapse. The expression of the therapeutic targets CD30, PD1, and PD-L1 can reliably be assessed in tumor specimen at first diagnosis and is unchanged under conventional chemotherapy.
      PubDate: 2019-03-11
       
  • Keeping tabs on the mabs: a hematopathologist’s dilemma
    • PubDate: 2019-02-22
       
  • Characterization of a t(1;2)(p36;p21) involving the PRDM16 gene region by
           mate-pair sequencing (MPseq) in a patient with newly diagnosed acute
           myeloid leukemia with myelodysplasia-related changes
    • Abstract: Abstract Per the 2017 WHO, several translocations have been described that are sufficient for the diagnosis of acute myeloid leukemia with myelodysplasia-related changes (AML-MRC) (assuming no prior therapy and ≥ 20% myeloblasts present in blood or bone marrow), including the t(1;3)(p36;q21). This translocation juxtaposes the RPN1 gene (3q21.2) promoter upstream of the PRDM16 gene (1p36) resulting in PRDM16 overexpression. While uncommon, PRDM16 overexpression is considered an unfavorable prognostic finding in myeloid neoplasms. A variant PRDM16 rearrangement t(1;2)(p36;p21) has been rarely described in various hematologic neoplasms, including two cases of myelodysplastic syndrome and one case each of myelofibrosis and T-lymphoblastic leukemia. We describe the first case to our knowledge of t(1;2)(p36;p21) observed in AML-MRC. In addition, a next-generation sequencing strategy, mate-pair sequencing (MPseq) was performed and revealed the promoter 2 region of THADA (2p21) was juxtaposed upstream from PRDM16 which may be responsible for PRDM16 overexpression that has been reported in hematologic neoplasms harboring the t(1;2)(p36;p21).
      PubDate: 2019-02-21
       
  • Reviewers for Journal of Hematopathology in 2018
    • PubDate: 2019-02-20
       
  • Incorporation of digital gene expression profiling for cell-of-origin
           determination (Lymph2Cx testing) into the routine work-up of diffuse large
           B cell lymphoma
    • Abstract: Abstract Diffuse large B cell lymphomas (DLBCL) represent a clinically heterogeneous group of lymphomas that are classified together based on similarities in morphology and immunophenotype. Gene expression profiling further classifies DLBCL into distinct molecular subgroups based on cell-of-origin (COO), including germinal center B cell type, activated B cell type, and unclassified type. COO assignment of DLBCL has important biological and prognostic significance, as well as emerging therapeutic implications. Herein, we describe the first clinical validation of a digital gene expression-profiling assay (Lymph2Cx) to perform COO assignment in the routine work-up of DLBCL using formalin-fixed paraffin-embedded (FFPE) tissue sections and describe the results of 90 consecutive DLBCL cases analyzed prospectively by a College of American Pathologists/Clinical Laboratory Improvement Amendments (CAP/CLIA)-certified clinical molecular diagnostics laboratory.
      PubDate: 2019-02-14
       
  • Plasma cell leukemia masquerading as lymphoplasmacytic lymphoma: a
           diagnostic challenge
    • PubDate: 2019-02-07
       
  • Leukemic presentation of high-grade B cell lymphoma with MYC and BCL2
           rearrangement—a series of two cases and review of literature
    • Abstract: Abstract High-grade B cell lymphoma (HGBL) is a recently introduced category of aggressive mature B cell lymphoma which is clinically and biologically distinct from diffuse large B cell lymphoma (DLBCL), NOS, and Burkitt Lymphoma. HGBL consists of two categories; the first category includes HGBL with MYC and BCL2 and/or BCL6 rearrangement which is so-called double or triple hit lymphoma. The second category includes HGBL, NOS which lacks genetic double or triple hit; however, its morphology is intermediate between DLBCL and Burkitt lymphoma or appear blastoid. Clinically, patients present with advanced disease, bone marrow involvement, elevated lactate dehydrogenase (LDH), extranodal disease which includes CNS involvement and a high international prognostic index (IPI). Leukemic presentation has been described in various types of B and T cell non-Hodgkin lymphoma; however, peripheral blood involvement as an initial presentation is seldom described in the literature for HGBL with MYC and BCL2 rearrangement. Here, we report two cases of HGBL whose initial presentation was leukocytosis with peripheral blood involvement mimicking acute leukemia.
      PubDate: 2019-01-31
       
  • Mediastinal germ cell tumor with associated myeloid sarcoma: An
           exceptional co-occurrence
    • Abstract: Abstract The association of mediastinal germ cell tumor (GCT) and hematological malignancy is a well-documented but extremely rare phenomenon. This syndrome is characterized by the occurrence of nonseminomatous mediastinal germ cell tumor and an associated hematological neoplasm that usually involve the megakaryocytic lineage. The hematopoietic malignancies can involve the mediastinum or present as infiltration of bone marrow or lymphoid organs. In majority of cases, the hematological malignancy was detected in the bone marrow simultaneously or within 6 months after the detection of mediastinal germ cell tumor. There are very few limited case reports on the presence of hematopoietic or leukemic cells within the germ cell tumor itself and mass formation due to myeloid sarcoma is exceptionally rare. Herein we report the case of a 36-year-old male patient with a large mediastinal mass, excision biopsy of which showed areas of yolk sac tumor, immature teratoma and a separate round cell component. On immunohistochemical examination, the round cell component showed positivity for CD45 (dim), CD43, MPO, CD11c, and CD68 and were negative for CD117, CD20, CD5, CD34, Tdt, CD30, CD123, and CD61. A diagnosis of mediastinal germ cell tumor with yolk sac tumor and immature teratoma components and associated myeloid sarcoma was given. Peripheral smear and bone marrow examination showed no evidence of leukemic involvement.
      PubDate: 2019-01-28
       
  • When the diagnosis is difficult to digest: severe vitamin B 12 deficiency
           secondary to pernicious anemia mimicking life-threatening thrombotic
           thrombocytopenic purpura
    • Abstract: Abstract Thrombotic thrombocytopenic purpura (TTP) is an uncommon yet life-threatening condition, usually marked by a classic pentad of microangiopathic hemolytic anemia (MAHA), thrombocytopenia, acute kidney injury (AKI), neurological disturbances, and fevers. Prompt recognition and treatment is essential to reduce morbidity and mortality. The rarity and variability of presentations, however, makes this a difficult diagnosis to make reliably, and in many cases, treatment is initiated empirically before the appropriate diagnostic testing is completed. After TTP and other common causes of thrombotic microangiopathy (TMA) have been excluded, evaluation for causes of “pseudo”-thrombotic microangiopathy (“pseudo”-TMA) should be pursued. Herein, we present a case of a young man with a history of previously treated hepatitis C virus (HCV) infection presenting with a syndrome concerning for TTP: MAHA, thrombocytopenia, and dizziness with gait ataxia. Disseminated intravascular coagulation (DIC) and autoimmune hemolysis were quickly ruled out, and plasma exchange was emergently initiated. Further workup identified an undetectably low vitamin B12 level with profound elevations in both homocysteine and methylmalonic acid (MMA) levels. Folate and vitamin B12 were replenished, with a rapid resolution of hemolysis and improvement in both the platelet count and hemoglobin that allowed for plasma exchange to be permanently discontinued. Further workup identified positivity of both intrinsic factor and parietal cell autoantibodies, suggesting a diagnosis of pernicious anemia. He was determined to have “pseudo”-TMA secondary to critical vitamin B12 deficiency. The patient was safely discharged home with scheduled subcutaneous vitamin B12 injections along with outpatient follow-up with both Hematology and Gastroenterology.
      PubDate: 2019-01-11
       
  • Autoimmune hemolytic anemia: an uncommon cause of elevated fetal
           hemoglobin
    • PubDate: 2019-01-08
       
  • CD38 negative anaplastic plasma cell myeloma with (14;16) translocation: a
           diagnostic dilemma for highly aggressive neoplasm: case report
    • Abstract: Abstract Anaplastic plasma cell myeloma (PCM) is an aggressive morphological variant of myeloma characterized by involvement of extramedullary sites and extremely poor prognosis. Moreover, anaplastic PCM is frequently associated with high frequency of 17p(p53) deletions, 1q21(CKS1B) amplifications and immunoglobulin A (IgA) isotype. It usually manifests as an adverse progression of previously treated conventional plasma cell myeloma. However, the anaplastic morphology can be encountered in newly diagnosed cases and might pose a major diagnostic challenge. Herein, we present a rare case of anaplastic plasma cell myeloma with (14;16) translocation which was diagnosed initially as a non-hematopoietic malignancies due to its unusual clinicopathological profile comprising acute presentation, extremely anaplastic morphology, and negative staining of CD38 immunohistochemical marker. In view of lack of clinical suspicion of plasma cell myeloma, no serological investigations for myeloma had been requested initially. In fact, high index of suspicion of myeloma arose only when results of MRI and CT scan came out revealing bony lytic lesions and collapsed vertebrae. Subsequently, bone marrow biopsy was repeated and revealed an extensive infiltration with sheets of neoplastic plasma cells which were strongly positive for CD138, KAPPA, and CD56 IHC markers.
      PubDate: 2019-01-02
       
  • Nodal mesenteric marginal zone lymphoma with amyloid deposits,
           calcification, and ossification
    • Abstract: Abstract Marginal zone lymphomas (MZLs) are rarely associated with amyloid deposits, calcification, and ossification. Herein, we describe a case of a MZL with a primary nodal mesenteric presentation, associated with amyloid deposits, calcification, and ossification, highlighting its clinicopathological features, based on our findings, but also on a brief review of the literature.
      PubDate: 2018-12-18
       
  • Nonconventional morphology in plasma cell leukemia
    • Abstract: Abstract Plasma cell leukemia is a rare malignancy with a poor outcome. Nonconventional morphology of circulating plasma cells is rare, but few case reports do exist. We present such a case that emphasizes the importance of integrating flow cytometric immunophenotyping to confirm the diagnosis.
      PubDate: 2018-12-01
       
  • Primary spinal T cell/histiocyte-rich large B cell lymphoma (THRLBCL)—a
           rare diagnosis at a rare site
    • Abstract: Abstract T cell/histiocyte-rich large B cell lymphoma (THRLBCL) is an unusual variant of diffuse large B cell lymphoma with poor prognosis. We describe a case of THRLBCL with an uncommon isolated spinal involvement. A 37-year-old male came to the neurosurgery outpatient department with weakness of both upper and lower limbs. Histopathology and immunohistochemistry revealed features consistent with THRLBCL. The patient was treated with D5-D6 laminectomy followed by six cycles of chemotherapy (CHOP; cyclophosphamide, hydroxydaunorubicin, oncovin, prednisolone) and was disease free for 5 years until he had relapse of disease at the same location in 2016 for which he is receiving palliative radiation therapy. Isolated spinal involvement as the first or only manifestation of THRLBCL is very rare and has been described very occasionally in the literature. It is important to correctly diagnose this entity and differentiate it from its mimics because of different prognostic and therapeutic implications.
      PubDate: 2018-12-01
       
  • Distribution of lymphomas in Mexico: a multicenter descriptive study
    • Abstract: Abstract Epidemiology of lymphoma is not well described in Mexico. We determined the frequencies and subtypes of the main non-Hodgkin’s and Hodgkin’s lymphomas in the Mexican population. Files for tissue samples for lymphomas stored in five different hospitals in Mexico City were retrieved for re-analysis and further immunostaining. The most common mature B cell, T cell/NK cell, Hodgkin’s, and precursor lymphoid neoplasms were identified according to the 2008 WHO classification of tumors. All stains were performed in the same laboratory and interpreted by three pathologists. Five thousand seven hundred seventy-two neoplasms were included. Of these, 4213 were mature B cell neoplasms (73%; 95% CI 71.83–74.12), 888 Hodgkin’s lymphomas (HLs) (15%; 95% CI 14.48–16.34), 496 mature T cell/NK neoplasms (9%; 95% CI 7.89–9.34), and 175 precursor lymphoid neoplasms (3%; 95% CI 2.62–3.5). Neoplasms had an even distribution between sexes. Main mature B cell lymphomas were diffuse large B cell lymphoma (DLBCL) (56%; 95% CI 54.39–57.39) and follicular lymphoma (FL) (20%; 95% CI 18.92–21.34). Hodgkin’s lymphomas were also classified into five main subtypes, with nodular sclerosis (47%; 95% CI 44.14–50.7) and mixed cellularity (38%; 95% CI 34.49–40.85) being the most common. The most common mature T cell/NK neoplasm was peripheral T cell lymphoma NOS/anaplastic large cell lymphoma ALK negative (44%; 95% CI 39.85–48.84). This is the first descriptive study in Mexico with a large sample of lymphomas classified according to the 2008 WHO classification. The results obtained are in keeping with the numbers described in other populations.
      PubDate: 2018-12-01
       
  • Synchronous discordant Epstein-Barr virus (EBV)–positive nodal T/NK-cell
           lymphoma and EBV-positive diffuse large B cell lymphoma in a patient with
           a history of EBV-positive Burkitt lymphoma
    • Abstract: Abstract In rare cases, patients present with multiple simultaneous lymphomas at one or more anatomic sites. These may be described as composite (occurring at one anatomic site) or discordant (occurring at different anatomic sites). Although the Epstein-Barr virus (EBV) is often implicated in the development of composite lymphoma, its role in the pathogenesis of discordant lymphoma is less clear. We report a case of discordant Epstein-Barr virus–associated lymphoma consisting of nodal T/NK-cell lymphoma and diffuse large B cell lymphoma in a patient with a history of EBV-positive Burkitt lymphoma post treatment. Simultaneous biopsies of the left and right femoral lymph nodes showed a synchronous nodal T/NK-cell lymphoma (left) and diffuse large B cell lymphoma (right). The nodal T/NK-cell lymphoma was morphologically and immunohistochemical distinct from the diffuse large B cell. Both the T/NK-cell component and the B cell component showed bright nuclear positivity with in situ hybridization for EBER. Molecular studies for C-myc were negative. The role played by the Epstein-Barr virus (EBV) in the pathogenesis of discordant T cell and B cell lymphoma is uncertain but may be clinically significant, particularly in the setting of prior EBV-positive lymphoma. Additional testing for immunodeficiency should be considered in these patients.
      PubDate: 2018-12-01
       
  • Post-transplant CD4+ non-cytotoxic γδ T cell lymphoma with lymph
           node involvement
    • Abstract: Abstract Gamma delta T cells represent a minor subset of the normal lymphocyte component of the human immune system, largely inhabiting mucosal surfaces. Gamma delta T cell lymphomas (γδ TCLs) are thought to be derived from these cells and are rare, extremely aggressive lymphomas that typically exhibit a cytotoxic phenotype and often present in extranodal sites, most commonly as cutaneous or hepatosplenic subtypes. The immunophenotype usually lacks both CD4 and CD8 expression, but occasional cases express CD8. CD4 expression in γδ TCLs is exceedingly rare. The few reported cases tend to show a non-cytotoxic phenotype with preferential involvement of the lymph nodes. Cases showing cutaneous presentation or with an immunosuppressive clinical history, while relatively common among typical γδ TCLs, are even rarer among this unusual CD4+ subset. While this very small group appears to have an equally dismal prognosis to other types of γδ TCL, little else is known as to how they may differ biologically and whether they should be treated as a separate entity. We report a unique case of CD4-positive gamma delta T cell lymphoma with skin and systemic lymph node involvement in the post-transplant setting.
      PubDate: 2018-12-01
       
  • Unusual morphology of multiple myeloma
    • Abstract: Abstract Multiple myeloma can have plasma cells with unusual morphology and a high index of suspicion is required to diagnose multiple myeloma with atypical morphology.
      PubDate: 2018-09-01
       
  • Immunophenotypic and cytogenetic evolution patterns of the neoplastic
           plasma cells in multiple myeloma relapsed after stem cell transplant
    • Abstract: Abstract Multiple myeloma (MM) is a neoplasm characterized by proliferation of clonal plasma cells (PCs) and a combination of clinical manifestations. Flow cytometry is an important method for diagnosing and monitoring of MM. Cytogenetic profiling of neoplastic PCs provides important prognostic information. Although stem cell transplantation (SCT) has significantly improved the overall survival of patients with MM, most SCT recipients relapse. We have studied the immunophenotypic and cytogenetic dissimilarities in the neoplastic PCs before SCT and after relapse in patients with initial complete remission, and investigated a possible influence of such dissimilarities on the patients’ survival. We retrospectively reviewed results of flow cytometric studies of bone marrow specimens from 46 patients with MM who underwent SCT, demonstrated a complete initial response, but subsequently relapsed. In nine of these patients, fluorescence in situ hybridization (FISH) studies were performed both pre-SCT and post-relapse. We have shown a significant flow cytometric and cytogenetic diversity of the neoplastic PCs in relapsed MM post-SCT. Such changes were detected in a considerable number of cases (47.8% and 44.4%, respectively). The most frequent cytogenetic changes indicate an emergence of possibly a more aggressive PC clone, known to be associated with worse prognosis and poorer outcome. Our study has demonstrated that the acquisition of immunophenotypic changes predicts worse overall survival.
      PubDate: 2018-09-01
       
  • Adult T cell leukemia/lymphoma complicated by proliferation of large B
           cells: a diagnostic dilemma
    • Abstract: Abstract Peripheral T cell lymphomas are clinically and pathologically complex and generally associated with overall poor prognosis and aggressive clinical course. In recent years, there is a greater recognition of abnormal B cell expansion as a component of T cell lymphomas especially those derived from follicular helper T cells. Most of these B cells are EBV positive and show a wide range of morphology which includes large mononuclear cells and Hodgkin-like cells. The number of the abnormal B cells can also vary. It is possible to misdiagnose this entity as a B cell lymphoma, Hodgkin lymphoma, composite lymphoma, or reactive lymphoid proliferation based on the number and morphology of the proliferating B cells. Herein, we report the case of an 82-year-old woman who presented with cervical lymphadenopathy, excision biopsy of which showed diffusely arranged atypical small- to medium-sized cells with irregular nuclei admixed with large number of immunoblast-like large cells. Immunophenotyping showed the small- to medium-sized cells to be CD20 negative, CD3 positive, and CD5 positive and showed downregulation of CD7. These cells were CD25 positive and showed a high MIB 1 labelling index. The large cells were CD20 positive and CD30 positive and showed EBV-encoded small nuclear RNA (EBER) positivity. Serum HTLV-1 estimation was positive. Molecular studies showed TCR gene rearrangement and a polyclonal population of B cells. Based on morphology, immunoprofile, and molecular studies, a diagnosis of adult T cell leukemia/lymphoma complicated by proliferation of large B cells was given. The presence of large B cell proliferation in adult T cell leukemia/lymphoma is an exceptionally rare phenomenon.
      PubDate: 2018-09-01
       
 
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