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  Subjects -> ENGINEERING (Total: 2462 journals)
    - CHEMICAL ENGINEERING (209 journals)
    - CIVIL ENGINEERING (212 journals)
    - ELECTRICAL ENGINEERING (116 journals)
    - ENGINEERING (1290 journals)
    - ENGINEERING MECHANICS AND MATERIALS (398 journals)
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ENGINEERING (1290 journals)                  1 2 3 4 5 6 7 | Last

Showing 1 - 200 of 1205 Journals sorted alphabetically
3 Biotech     Open Access   (Followers: 8)
3D Research     Hybrid Journal   (Followers: 20)
AAPG Bulletin     Hybrid Journal   (Followers: 8)
AASRI Procedia     Open Access   (Followers: 15)
Abstract and Applied Analysis     Open Access   (Followers: 3)
Aceh International Journal of Science and Technology     Open Access   (Followers: 5)
ACS Nano     Hybrid Journal   (Followers: 300)
Acta Geotechnica     Hybrid Journal   (Followers: 7)
Acta Metallurgica Sinica (English Letters)     Hybrid Journal   (Followers: 7)
Acta Polytechnica : Journal of Advanced Engineering     Open Access   (Followers: 3)
Acta Scientiarum. Technology     Open Access   (Followers: 3)
Acta Universitatis Cibiniensis. Technical Series     Open Access  
Active and Passive Electronic Components     Open Access   (Followers: 7)
Adaptive Behavior     Hybrid Journal   (Followers: 10)
Adıyaman Üniversitesi Mühendislik Bilimleri Dergisi     Open Access  
Adsorption     Hybrid Journal   (Followers: 4)
Advanced Engineering Forum     Full-text available via subscription   (Followers: 9)
Advanced Journal of Graduate Research     Open Access  
Advanced Nonlinear Studies     Hybrid Journal  
Advanced Science     Open Access   (Followers: 6)
Advanced Science Focus     Free   (Followers: 5)
Advanced Science Letters     Full-text available via subscription   (Followers: 11)
Advanced Science, Engineering and Medicine     Partially Free   (Followers: 7)
Advanced Synthesis & Catalysis     Hybrid Journal   (Followers: 17)
Advances in Calculus of Variations     Hybrid Journal   (Followers: 4)
Advances in Catalysis     Full-text available via subscription   (Followers: 5)
Advances in Complex Systems     Hybrid Journal   (Followers: 7)
Advances in Engineering Software     Hybrid Journal   (Followers: 28)
Advances in Fuel Cells     Full-text available via subscription   (Followers: 16)
Advances in Fuzzy Systems     Open Access   (Followers: 5)
Advances in Geosciences (ADGEO)     Open Access   (Followers: 14)
Advances in Heat Transfer     Full-text available via subscription   (Followers: 23)
Advances in Human Factors/Ergonomics     Full-text available via subscription   (Followers: 22)
Advances in Magnetic and Optical Resonance     Full-text available via subscription   (Followers: 8)
Advances in Natural Sciences: Nanoscience and Nanotechnology     Open Access   (Followers: 29)
Advances in Nonlinear Analysis     Hybrid Journal  
Advances in Operations Research     Open Access   (Followers: 12)
Advances in OptoElectronics     Open Access   (Followers: 6)
Advances in Physics Theories and Applications     Open Access   (Followers: 16)
Advances in Polymer Science     Hybrid Journal   (Followers: 45)
Advances in Porous Media     Full-text available via subscription   (Followers: 5)
Advances in Remote Sensing     Open Access   (Followers: 49)
Advances in Science and Research (ASR)     Open Access   (Followers: 6)
Aerobiologia     Hybrid Journal   (Followers: 3)
African Journal of Science, Technology, Innovation and Development     Hybrid Journal   (Followers: 6)
AIChE Journal     Hybrid Journal   (Followers: 35)
Ain Shams Engineering Journal     Open Access   (Followers: 5)
Akademik Platform Mühendislik ve Fen Bilimleri Dergisi     Open Access   (Followers: 1)
Al-Nahrain Journal for Engineering Sciences     Open Access  
Alexandria Engineering Journal     Open Access   (Followers: 1)
AMB Express     Open Access   (Followers: 1)
American Journal of Applied Sciences     Open Access   (Followers: 27)
American Journal of Engineering and Applied Sciences     Open Access   (Followers: 10)
American Journal of Engineering Education     Open Access   (Followers: 11)
American Journal of Environmental Engineering     Open Access   (Followers: 16)
American Journal of Industrial and Business Management     Open Access   (Followers: 25)
Annals of Combinatorics     Hybrid Journal   (Followers: 4)
Annals of Pure and Applied Logic     Open Access   (Followers: 3)
Annals of Regional Science     Hybrid Journal   (Followers: 7)
Annals of Science     Hybrid Journal   (Followers: 7)
Antarctic Science     Hybrid Journal   (Followers: 1)
Applicable Algebra in Engineering, Communication and Computing     Hybrid Journal   (Followers: 2)
Applicable Analysis: An International Journal     Hybrid Journal   (Followers: 1)
Applied Catalysis A: General     Hybrid Journal   (Followers: 6)
Applied Catalysis B: Environmental     Hybrid Journal   (Followers: 20)
Applied Clay Science     Hybrid Journal   (Followers: 6)
Applied Computational Intelligence and Soft Computing     Open Access   (Followers: 13)
Applied Magnetic Resonance     Hybrid Journal   (Followers: 4)
Applied Nanoscience     Open Access   (Followers: 8)
Applied Network Science     Open Access   (Followers: 3)
Applied Numerical Mathematics     Hybrid Journal   (Followers: 5)
Applied Physics Research     Open Access   (Followers: 6)
Applied Sciences     Open Access   (Followers: 3)
Applied Spatial Analysis and Policy     Hybrid Journal   (Followers: 5)
Arab Journal of Basic and Applied Sciences     Open Access  
Arabian Journal for Science and Engineering     Hybrid Journal   (Followers: 5)
Archives of Computational Methods in Engineering     Hybrid Journal   (Followers: 5)
Archives of Foundry Engineering     Open Access  
Archives of Thermodynamics     Open Access   (Followers: 9)
Arkiv för Matematik     Hybrid Journal   (Followers: 1)
ASEE Prism     Full-text available via subscription   (Followers: 3)
Asia-Pacific Journal of Science and Technology     Open Access  
Asian Engineering Review     Open Access  
Asian Journal of Applied Science and Engineering     Open Access   (Followers: 1)
Asian Journal of Applied Sciences     Open Access   (Followers: 2)
Asian Journal of Biotechnology     Open Access   (Followers: 9)
Asian Journal of Control     Hybrid Journal  
Asian Journal of Current Engineering & Maths     Open Access  
Asian Journal of Technology Innovation     Hybrid Journal   (Followers: 8)
Assembly Automation     Hybrid Journal   (Followers: 2)
at - Automatisierungstechnik     Hybrid Journal   (Followers: 1)
ATZagenda     Hybrid Journal  
ATZextra worldwide     Hybrid Journal  
Australasian Physical & Engineering Sciences in Medicine     Hybrid Journal   (Followers: 1)
Australian Journal of Multi-Disciplinary Engineering     Full-text available via subscription   (Followers: 2)
Automotive Experiences     Open Access  
Autonomous Mental Development, IEEE Transactions on     Hybrid Journal   (Followers: 8)
Avances en Ciencias e Ingeniería     Open Access  
Balkan Region Conference on Engineering and Business Education     Open Access   (Followers: 1)
Bangladesh Journal of Scientific and Industrial Research     Open Access  
Basin Research     Hybrid Journal   (Followers: 5)
Batteries     Open Access   (Followers: 6)
Bautechnik     Hybrid Journal   (Followers: 1)
Bell Labs Technical Journal     Hybrid Journal   (Followers: 28)
Beni-Suef University Journal of Basic and Applied Sciences     Open Access   (Followers: 4)
BER : Manufacturing Survey : Full Survey     Full-text available via subscription   (Followers: 1)
BER : Motor Trade Survey     Full-text available via subscription  
BER : Retail Sector Survey     Full-text available via subscription   (Followers: 1)
BER : Retail Survey : Full Survey     Full-text available via subscription   (Followers: 1)
BER : Survey of Business Conditions in Manufacturing : An Executive Summary     Full-text available via subscription   (Followers: 3)
BER : Survey of Business Conditions in Retail : An Executive Summary     Full-text available via subscription   (Followers: 3)
Beyond : Undergraduate Research Journal     Open Access  
Bhakti Persada : Jurnal Aplikasi IPTEKS     Open Access  
Bharatiya Vaigyanik evam Audyogik Anusandhan Patrika (BVAAP)     Open Access   (Followers: 1)
Bilge International Journal of Science and Technology Research     Open Access  
Biofuels Engineering     Open Access   (Followers: 1)
Biointerphases     Open Access   (Followers: 1)
Biomaterials Science     Full-text available via subscription   (Followers: 11)
Biomedical Engineering     Hybrid Journal   (Followers: 16)
Biomedical Engineering     Hybrid Journal   (Followers: 1)
Biomedical Engineering and Computational Biology     Open Access   (Followers: 13)
Biomedical Engineering Letters     Hybrid Journal   (Followers: 5)
Biomedical Engineering, IEEE Reviews in     Full-text available via subscription   (Followers: 20)
Biomedical Engineering, IEEE Transactions on     Hybrid Journal   (Followers: 35)
Biomedical Engineering: Applications, Basis and Communications     Hybrid Journal   (Followers: 5)
Biomedical Microdevices     Hybrid Journal   (Followers: 8)
Biomedical Science and Engineering     Open Access   (Followers: 4)
Biomicrofluidics     Open Access   (Followers: 5)
BioNanoMaterials     Open Access   (Followers: 2)
Biotechnology Progress     Hybrid Journal   (Followers: 41)
Bitlis Eren University Journal of Science and Technology     Open Access  
Boletin Cientifico Tecnico INIMET     Open Access  
Botswana Journal of Technology     Full-text available via subscription   (Followers: 1)
Boundary Value Problems     Open Access   (Followers: 1)
Brazilian Journal of Science and Technology     Open Access   (Followers: 2)
Broadcasting, IEEE Transactions on     Hybrid Journal   (Followers: 12)
Bulletin of Canadian Petroleum Geology     Full-text available via subscription   (Followers: 13)
Bulletin of Engineering Geology and the Environment     Hybrid Journal   (Followers: 14)
Bulletin of the Crimean Astrophysical Observatory     Hybrid Journal  
Cahiers Droit, Sciences & Technologies     Open Access  
Calphad     Hybrid Journal   (Followers: 2)
Canadian Geotechnical Journal     Hybrid Journal   (Followers: 31)
Canadian Journal of Remote Sensing     Full-text available via subscription   (Followers: 43)
Carbon Resources Conversion     Open Access   (Followers: 1)
Case Studies in Engineering Failure Analysis     Open Access   (Followers: 6)
Case Studies in Thermal Engineering     Open Access   (Followers: 6)
Catalysis Communications     Hybrid Journal   (Followers: 6)
Catalysis Letters     Hybrid Journal   (Followers: 2)
Catalysis Reviews: Science and Engineering     Hybrid Journal   (Followers: 7)
Catalysis Science and Technology     Free   (Followers: 8)
Catalysis Surveys from Asia     Hybrid Journal   (Followers: 3)
Catalysis Today     Hybrid Journal   (Followers: 7)
CEAS Space Journal     Hybrid Journal   (Followers: 2)
Cellular and Molecular Neurobiology     Hybrid Journal   (Followers: 3)
Central European Journal of Engineering     Hybrid Journal  
Chaos : An Interdisciplinary Journal of Nonlinear Science     Hybrid Journal   (Followers: 3)
Chaos, Solitons & Fractals     Hybrid Journal   (Followers: 3)
Chinese Journal of Catalysis     Full-text available via subscription   (Followers: 2)
Chinese Journal of Engineering     Open Access   (Followers: 2)
Chinese Science Bulletin     Open Access   (Followers: 1)
Ciencia e Ingenieria Neogranadina     Open Access  
Ciencia en su PC     Open Access   (Followers: 1)
Ciencia y Tecnología     Open Access  
Ciencias Holguin     Open Access   (Followers: 3)
CienciaUAT     Open Access   (Followers: 1)
Cientifica     Open Access  
CIRP Annals - Manufacturing Technology     Full-text available via subscription   (Followers: 11)
CIRP Journal of Manufacturing Science and Technology     Full-text available via subscription   (Followers: 13)
City, Culture and Society     Hybrid Journal   (Followers: 22)
Clean Air Journal     Full-text available via subscription   (Followers: 1)
Clinical Science     Hybrid Journal   (Followers: 9)
Coal Science and Technology     Full-text available via subscription   (Followers: 3)
Coastal Engineering     Hybrid Journal   (Followers: 11)
Coastal Engineering Journal     Hybrid Journal   (Followers: 6)
Coatings     Open Access   (Followers: 4)
Cogent Engineering     Open Access   (Followers: 3)
Cognitive Computation     Hybrid Journal   (Followers: 4)
Color Research & Application     Hybrid Journal   (Followers: 3)
COMBINATORICA     Hybrid Journal  
Combustion Theory and Modelling     Hybrid Journal   (Followers: 14)
Combustion, Explosion, and Shock Waves     Hybrid Journal   (Followers: 15)
Communications Engineer     Hybrid Journal   (Followers: 1)
Communications in Information Science and Management Engineering     Open Access   (Followers: 4)
Communications in Numerical Methods in Engineering     Hybrid Journal   (Followers: 2)
Components, Packaging and Manufacturing Technology, IEEE Transactions on     Hybrid Journal   (Followers: 28)
Composite Interfaces     Hybrid Journal   (Followers: 7)
Composite Structures     Hybrid Journal   (Followers: 294)
Composites Part A : Applied Science and Manufacturing     Hybrid Journal   (Followers: 227)
Composites Part B : Engineering     Hybrid Journal   (Followers: 266)
Composites Science and Technology     Hybrid Journal   (Followers: 203)
Comptes Rendus Mécanique     Full-text available via subscription   (Followers: 2)
Computation     Open Access   (Followers: 1)
Computational Geosciences     Hybrid Journal   (Followers: 17)
Computational Optimization and Applications     Hybrid Journal   (Followers: 8)
Computational Science and Discovery     Full-text available via subscription   (Followers: 2)
Computer Applications in Engineering Education     Hybrid Journal   (Followers: 8)
Computer Science and Engineering     Open Access   (Followers: 19)
Computers & Geosciences     Hybrid Journal   (Followers: 31)
Computers & Mathematics with Applications     Full-text available via subscription   (Followers: 9)
Computers and Electronics in Agriculture     Hybrid Journal   (Followers: 5)

        1 2 3 4 5 6 7 | Last

Journal Cover
Beni-Suef University Journal of Basic and Applied Sciences
Number of Followers: 4  

  This is an Open Access Journal Open Access journal
ISSN (Print) 2314-8535
Published by Elsevier Homepage  [3162 journals]
  • Cultural Optimization of a New Exopolysaccharide Producer “Micrococcus
           Roseus”

    • Abstract: Publication date: Available online 7 July 2018Source: Beni-Suef University Journal of Basic and Applied SciencesAuthor(s): Faten hereher, Amira ElFallal, Mohammed Abou-Dobara The ability to produce polysaccharides is widely spread among bacteria. The usefulness of EPS molecules makes development of new strategies for improved synthesis of EPS is a necessity. A novel EPS Producer promisingly was obtained from a culture of Micrococcus roseus. In the present investigation, two screening steps for exopolysaccharide production were done using 9 strains and 7 isolates of different taxonomic bacterial groups isolated from different soil samples together with bacterial strains obtained from culture collections. The first screening for EPS-production was done on solid basal media based on the mucous aspect of colonies. The slimiest and mucous bacterial strains were again screened for EPS production in liquid cultures. Comparative data of the eleven bacterial strains showed that Micrococcus roseus proved to produce the maximum EPS in shacked culture and the maximum EPS production was amounting to 1.805 g EPS/l. An attempt was made to optimize and maximize the production of EPS by M. roseus. Maximum EPS production of 800 mg/100 ml observed after 96 h incubation at 25 ◦C using 4.5 % and 0.02% of sucrose and ammonium sulphate concentration respectively at pH 7.0. A preliminary structural elucidation of the exopolysaccharide of M. roseus was done using spectroscopic technique FTIR and showed a characteristic band attributed to (1-3) β glucan linkage. The monomeric composition was glucose, galactose and rhmnose with two carbohydrate and protein portions 91.3 % and 8.7 % respectively.
       
  • Pathogenicity of Escherichia coli O157 in commercial broiler chickens

    • Abstract: Publication date: Available online 5 July 2018Source: Beni-Suef University Journal of Basic and Applied SciencesAuthor(s): Azza. A. EL-Sawah, ALHussien M. Dahshan, El-Shaymaa El-NAHASS, A.I.Abd El-Mawgoud Broiler chickens are frequently infected with Escherichia coli (E.coli), which often results in disease and high economic losses. The most affected ages to infections with E.coli are chickens from 4-5 weeks. Several studies show that poultry are already and persistently infected by E.coli O157. The current study aimed to determine the pathogenicity of E.coli serogroup O157 in broiler chicks, a trial of prevention and treatment using probiotic and/or antibiotic. The chicks were divided into five groups including control negative, control positive, probiotic treated group, probiotic and antibiotic treated group and finally antibiotic treated group. The clinical signs, mortality, performance parameters, postmortem examination, re-isolation and E. coli count as well as the pathological changes in liver and intestine were recorded. The probiotic group gave the best results in controlling infection by E.coli O157 followed by probiotic and antibiotic and finally antibiotic. In conclusion, the E.coli O157 serogroup was pathogenic to chicks when experimentally inoculated, so particular attention must be directed toward E.coli O157 not only as a pathogen infecting bird but also of great public health impact. Also probiotics was of great value in protection against the E.coli infection and improve the performance parameters of chicks.
       
  • Evaluation of optimization parameters in microwave reflux extraction of
           peperine-oleoresin from black pepper (piper nigrum)

    • Abstract: Publication date: Available online 5 July 2018Source: Beni-Suef University Journal of Basic and Applied SciencesAuthor(s): Olusegun Abayomi Olalere, Nour Hamid Abdurahman, Rosli bin Mohd Yunus, Oluwaseun Ruth Alara, Sweeter Akbari Black pepper is a functional plant with nutritional and medicinal benefits. Piperine being the major bioactive compound in black pepper has been applied for the treatment of many free radical-related diseases. This study determined a combination of operating parameters that optimize the microwave extraction of the piperine oil. The effect of irradiation time, microwave power level, feed particle size and feed-solvent ratio on piperine content and absorbed microwave energy were tested using a three-level L9-Taguchi parametric design. The results obtained placed the optimum extraction condition at 90 min of irradiation time, 350 W of microwave power, 0.1 mm of particle size and 1:12 of feed-solvent ratio. Under this optimal condition the optimal piperine oil and absorbed microwave energy of 5.64 w/w and 84.17 J/min were obtained, respectively. The optimal conditions can therefore be employed to design extraction process with higher efficiency and productivity.
       
  • Two spectrophotometric methods for quantitative determination of some
           pesticides applied for cucumber in Egypt

    • Abstract: Publication date: Available online 4 July 2018Source: Beni-Suef University Journal of Basic and Applied SciencesAuthor(s): Amira M. Hegazy, Rehab M. Abdelfatah, Hamada M. Mahmoud, Mohamed A. Elsayed Specific spectroscopic techniques were validated for assay of four pesticides applied for cucumber in Egypt; mandipropamid (MAN), metalaxyl (MET), thiophenate methyl (THO) and carbendazim (CAR). First method is derivative method for the quaternary mixture of the studied pesticides; by using the first derivative THO was assayed at 281 nm, while MAN and CAR were assayed using second derivative at 236.4 and 256.2 nm, respectively and MET was assayed using third derivative at 221.6 nm. Second method is double divisor ratio spectrum derivative method that used for assay of MAN at 289 nm and MET at 233.2 nm using a double divisor of 30 μg mL−1 of each of THO and CAR, then both THO and CAR were determined at 259 and 267.4 nm, respectively, using a double divisor of 4 μg mL−1 of each of MAN and MET. The obtained results were within the acceptable range regarding to the Egyptian committee of agricultural recommendations.
       
  • Comparative morphological study of three species of Saraca L. (Fabaceae)
           by the statistical approach to find out the logic of potent morphological
           markers

    • Abstract: Publication date: Available online 3 July 2018Source: Beni-Suef University Journal of Basic and Applied SciencesAuthor(s): Sujit Sil, Tanmoy Mallick, Kalyan Kumar De, Arabinda Pramanik, Asok Ghosh The genus Saraca L. (Fabaceae s.l.) has 11 species among which three are distributed in India. This study is done for these three species as S. indica L., S. declinata (Jack) Miq., and S. thaipingensis Cantley ex Prain which are taxonomically recognized and identified by morphological characters, both of vegetative and reproductive. As a common trend of taxonomic study key to the identification of taxa is based on contrast pairs of lead characters considering as good characters to the taxonomic work when these characters are different in different taxa. The present study is emphasized here again to find out the marker characters for identity with the approach of preparation of ternary plot considering 82 characters through statistical method. Morphological characters like the texture of ovary, the presence of hood on anther and distribution of hairs on anther, bract and stigma morphology, shape and size of the seed, pollen surface etc. are found to be potent morphological markers for these three species of Saraca. The marker character to prepare a better key of identity is also established by this method. Earlier works on taxonomy also support this finding. The results show the relationship and character correlation amongst the species as S. declinata is more close to S. thaipingensis than S. indica. This work approaches a basis to strengthen a part of classical taxonomy.
       
  • A novel chalcone derivative from Punica granatum peel inhibits
           LOX/COX enzyme activity

    • Abstract: Publication date: Available online 3 July 2018Source: Beni-Suef University Journal of Basic and Applied SciencesAuthor(s): Sudheesh S., Soumya K., Jesna James The present study evaluates the Lipoxygenase (LOX) and cyclooxygenase (COX) inhibitory activity of a flavonoid isolated from Punica granatum peel. The molecular structure and chemical bonds were analyzed using UV–Visible, FT-IR, 1H NMR and Mass spectra. The structure of the compound was identified as a novel derivative of chalcone. The isolated compound was interpreted as (2E)-3-(4-hydroxy-3-pentylphenyl)-1-(2-hydroxy-4,5-di((E)-prop-1-enyl)phenyl)prop-2-en-1-one. A prominent inhibition on LOX and COX was observed. The in vitro study indicates the potential of isolated compound to use as an anti-inflammatory agent.
       
  • Clerodendrum volubile P. Beauv (Lamiaceae), an underutilized indigenous
           vegetable of utmost nutritive and pharmacological importance

    • Abstract: Publication date: Available online 2 July 2018Source: Beni-Suef University Journal of Basic and Applied SciencesAuthor(s): Abdulwakeel Ayokun-nun Ajao, Michael Ojo Oseni, Olaniran Temitope Oladipo, Yusuf Agbomekhe Adams, Yusuf Ola Mukaila, Abdulwadud Abiodun Ajao Clerodendrum volubile is an underutilized vegetable native to West Africa most especially Nigeria. The plant is used traditionally in the treatment of arthritis, diabetes, dropsy, gout rheumatism, dropsy, swellings, oedema, and analgesic. The ethnopharmacological potential of C. volubile through its phytochemistry, biological activities, and proximate analysis was reviewed for the first time. Published articles on C. volubile were sourced from scientific data bases such as Google Scholar, Medicine, PubMed, Science Direct, and Scopus. C. volubile contains appreciable quantity of phytochemicals and compounds such as ajugoside, pectolinarigenin, protocatechuic acid, biochanin, and 5, 7,4'-Trimethoxykaempferol. It also elicited wide range of biological activities such as antidiabetic, antihyperlipidemic, anti-hypertension, antioxidant, anticancer, anti-inflammatory, hepatoprotective, antimicrobial, and analgesic. C. volubile is a potential pharmaceutical agent especially in the treatment of cancer due to the ability of its extracts to scavenge reactive oxygen species. Future research should focus on isolation of bioactive compounds responsible for elicited activities and mechanism of action of the bioactivities through in vivo studies.
       
  • Assessment of proliferative index in different grades of breast cancers
           using AgNOR (Agyrophilic Nuclear Organizer Region) expression

    • Abstract: Publication date: Available online 30 June 2018Source: Beni-Suef University Journal of Basic and Applied SciencesAuthor(s): Williams Kweku Darkwah, Gideon Aidoo, Yanhui Ao, Kwabena Owusu Danquah, Ernest Adjei, Ernest Adankwah, Alhassan Kadri Nucleolar organiser regions (NORs) are loops of DNA which are responsible for ribosomal RNA (rRNA) transcription in the nucleus of cells. NORs can be selectively stained by silver methods. The NORs agyrophilia is due to a group of nucleolar proteins, which have affinity for silver (Agyrophilic Nucleolar Organizer Regions, AgNOR proteins). The aim of the present study is to assess proliferative index in different grades of invasive ductal carcinoma (IDC) by using AgNOR as a marker. A total of 18 formalin fixed paraffin-embedded breast tissue blocks were retrieved from the archives of the histopathology department of the Komfo Anokye Teaching Hospital, Ghana. The tissue blocks included 17 IDC, (with 8 as grade 2 IDC, 9 as grade 3 IDC) and 1 normal breast tissues. Tissue sections were diagnosed and graded following haematoxylin and eosin (H&E) staining. Silver staining was used to demonstrate the presence of AgNOR. The AgNOR dots were manually counted in 50 and 100 cells. The mean AgNOR count (mAgNOR) and proliferative index, (pAgNOR, percentage of cells with ≥5 AgNOR dots per nucleus), significantly increased with increasing grade of IDC. The mAgNOR and pAgNOR were low in normal breast, (at p-value less than 0.05). There was no significant difference in the mAgNOR and pAgNOR score for counting 50 and 100 cells (at a p-value of 0.01). mAgNOR and pAgOR increases with increase in grade of IDC and hence can be used to assess proliferative index of IDC.
       
  • Synthesis, characterization and the role of ionic radii on the mechanistic
           of solvothermal for polyazine PtIV complexes: reduction PtIV to PtII, DFT,
           x-ray single crystal and anticancer studies

    • Abstract: Publication date: Available online 28 June 2018Source: Beni-Suef University Journal of Basic and Applied SciencesAuthor(s): Waleed H. Al-Assy, Said A.I. Mahmoud, Dalal Z. Husein, Mohsen M. Mostafa _________________________________________________________________________Polypyridyl based on triazine and pyrazine rings with Pt4+, including 2,4,6-tris(2-pyridyl)-1,3,5-triazine (TPT, L1) and 2,3,5,6-tetra(2-pyridyl)-1,4-triazine (TPP, L2), was reported. [Pt34+ (TPT)2Cl8]Cl4.2H2O (1) and [Pt4+(TPP)Cl3]Cl.3H2O (2) were synthesized and characterized. Comparative studies of the solvothermal of Pt4+ complexes and the stability studies of triazine and pyrazine moieties were investigated. Pt2+ complex, [PtII(bpca)Cl], resulted from the metal-promoted solvolysis of L1 to bis-(2-pyridylcarbonyl) amide anion (bpca) and 2-picolinamide, gives yellow single crystal, C12H8ClN3O2Pt (3). The effect of ionic radii of the metal ions has a vital role in solvolysis process. The single crystal shows a square-planar around the Pt2+ ion (3). Crystal data of 3: space group; a = 7.5263 (2) b = 14.1846 (4) c = 22.6884 (7) Å, α = β = γ = 90o, V = 2422.16 (12) Å3, Z = 8. The DFT parameters were calculated to confirm the geometry of complexes. Anticancer activity of complexes was measured.
       
  • Response surface optimization and effects of agricultural wastes on total
           petroleum hydrocarbon degradation

    • Abstract: Publication date: Available online 28 June 2018Source: Beni-Suef University Journal of Basic and Applied SciencesAuthor(s): Kingsley Amechi Ani, Ebere Ochin This study was carried out to investigate the effects of Goat manure (GM) and Palm oil mill effluent (POME) on total petroleum hydrocarbons (TPHs) degradation. Microbial respiration rates (CO2 evolution) were investigated. TPHs degradation rate constants were estimated using the first-order kinetics model. Scanning electron microscope (SEM) and infrared spectroscopy (FT-IR) were used to investigate the surface morphologies and functional groups in GM and POME. The CO2 evolution rates in TPH contaminated soil treated with GM (TPHCS-GM), TPH contaminated soil treated with POME (TPHCS-POME), and the untreated TPH contaminated soil (UTPHCS) were 497 mg/g, 440 mg/g, and 296 mg/g, respectively. TPHCS-GM showed higher TPH degradation rate with corresponding lower half-lives. Results from the physiochemical characterization indicated that GM performed better in restoring the scarce nutrient in the TPH contaminated soil. 58% and 39% of TPH were degraded at pH 8 and 4 in TPHCS-GM and TPHCS-POME, respectively. The response surface optimization process indicated the accuracy of the quadratic model (R2 value of 0.9891) in predicting TPH degradation (76.59%) with optimum independence variables of initial TPH concentration (300 g/L) and pH (6). The results obtained from this work showed the positive prospects of GM and POME as organic nutrients in TPH contaminated soil.
       
  • A review on Adenium obesum: A potential endemic medicinal plant
           in Oman

    • Abstract: Publication date: Available online 25 June 2018Source: Beni-Suef University Journal of Basic and Applied SciencesAuthor(s): Md. Amzad Hossain Medicinal plants have played a vital role in the treatment of various human diseases and development of the society since the ancient times. Medicinal plants are the only safe sources for new drugs to treat curable and incurable diseases. About 25% of the prescription drugs available worldwide are derived from natural resources. Adenium obesum (AO) is one of the rare endemic medicinal plants in Oman and it belongs to family Apocynaceae. A biochemical investigation of the local AO species showed that the selected plant contained different groups of chemical compounds such as carbohydrate, cardiac glycoside, flavonoid, prenylated flavonoids, terpenoids, pregnanes etc. In addition, the pharmacological activities on the selected Omani species showed significant antimicrobial, antioxidant, anticancer, antiviral and immune modulatory activities. Only a few scientific research has been performed on the indigenous AO plant species. For this reason, it is mandatory for human, mainly the young generation to be aware of the toxicity, biochemical and pharmacological activities of the selected AO plant species. This comprehensive review report of the selected medicinal plant includes taxonomy, biological activity, phytochemicals, and potential uses. The study concludes that the plant extracts or isolated phytochemicals might be used as safe novel medicine in the near future for therapy and prevention of different diseases in the near future.
       
  • Uranium potentiality mapping of G-V occurrence at Gabal Gattar area, North
           Eastern Desert, Egypt, using GIS approach

    • Abstract: Publication date: Available online 21 June 2018Source: Beni-Suef University Journal of Basic and Applied SciencesAuthor(s): Mohamed A. El Zalaky Delineation and evaluation of mineral resources are major exploration parameters required for investment decisions. Identifying the best probable sites for uranium mineralization in terrains of lack subsurface penetrations is a challenging task. In northern part of Egyptian Eastern Desert, the uranium occurrences of Gabal Gattar area are among the most important source of uranium mineralization. Gattar-V (G-V) uranium occurrence considered as the most important uranium locality in the northern parts of Gabal Gattar area. The well-known uranium mineralization in this occurrence is restricted to the geological contact zone between the Hammamat sedimentary rocks and the G. Gattar Alkali feldspar granite. The lithological units and their alteration zones that are associated with the uranium mineralization and the ground spectrometric measurements data are identified and delineated throughout the field work of the geological investigation. In addition to the delineation of visible uranium mineralized zones, useful aid for the location of uranium promising zones is provided. Uranium potential (UP) mapping is a systematic tools that considers the main controlling factors which influence the localization of uranium mineralization within their host rocks. The present study aims to highlight, identify, model and map uranium promising zones in G-V uranium occurrence by using Geographic Information System (GIS) to construct multiple geological thematic maps such as different kind of alteration, contact zone, radiometric measurement and secondary zones of uranium mineralization. The constructed thematic maps of the different controlling factors of U-mineralization are assigned with a fixed score, weight, and calculated using a linear equation approach. Each weighted thematic map is statistically calculated to produce a uranium potential levels map of the investigated area. The uranium potential areas thus obtained were classified into four classes of potentiality (very high, high, moderate and low). The obtained an integrated uranium potential map of the investigated area will be a useful guide in the mining planning activity and create a good decision for better planning and management of uranium resource.
       
  • Plackett-Burman design for screening of process components and their
           effects on production of lactase by newly isolated Bacillus sp. VUVD101
           strain from Dairy effluent

    • Abstract: Publication date: Available online 21 June 2018Source: Beni-Suef University Journal of Basic and Applied SciencesAuthor(s): Abraham Peele Karlapudi, S. Krupanidhi, Rajeswara Reddy E., Indira M., N. Bobby Md., Venkateswarulu T.C. In the present investigation, a low-cost fermentation medium was designed to achieve the maximum production of lactase from the Bacillus sp. VUVD101 strain through the screening of different nutritional and physical variables, using the Plackett-Burman design. Fourteen variables of the fermentation process were selected: incubation time, temperature, pH, RPM, DO, inoculum size, inoculum age, MgSO4, l-Cysteine, KH2PO4, CaCl2, K2PHO4, corn steep liquor and lactose. The selected variables were evaluated through statistical analysis, based on their significance, coefficient value and standard effect plot. The results suggested that six variables, namely, corn steep liquor, lactose, MgSO4, temperature, pH and RPM, had influence with high confidence levels, while the remaining eight variables did not show a significant effect on production. The analysis of the variance value R2 (0.96) also showed the model used for prediction to be significant (p less than 0.05). The plot for the standard effect for each component and its traits provided accurate data by which to select well-suited variables for further optimization. In comparison with the basal medium, 68% higher enzyme activity was achieved from the model of the optimized medium, and lactase activity was found to be 18.31 U/ml.
       
  • Effect of intranasal insulin on peripheral glucose profile in
           dexamethasone-induced insulin resistance in Wistar rats

    • Abstract: Publication date: Available online 7 June 2018Source: Beni-Suef University Journal of Basic and Applied SciencesAuthor(s): Anoka A. Njan, Chloe O. Fatigun, Abdul-Musawwir Alli-Oluwafuyi, Olufunke E. Olorundare, Olarenwaju S. Afolabi, Olugbenga Akinola, Abdulbasit Amin This study evaluates the therapeutic potential of intranasal insulin (INI) in dexamethasone-induced insulin resistance in Wistar rats. In the first phase of the study, thirteen, healthy, untreated male Wistar rats were divided into 2 groups and administered either vehicle (0.9% Normal saline, 20 µl) or insulin (2 IU) intranasally to assess intranasal delivery of insulin in brain. In the second phase of experiments, to evaluate the acute effects of intranasal insulin on peripheral blood glucose, intranasal or intraperitoneal insulin was co-administered with or without dexamethasone 10 mg/kg to 26 male Wistar rats and blood glucose monitored. To evaluate effect of intranasal insulin in peripheral metabolic disease model, insulin or vehicle was administered via intranasal or intraperitoneal (IP) route to control or dexamethasone (Dex)-treated (0.5 mg/kg, IP) female Wistar rats for seven consecutive days. Twenty-four hours after last dose, trunk blood was collected via cardiac puncture. Biochemical assay of glucose, lipid and insulin was performed on serum while enzyme activity – glucokinase and glucose-6-phosphatase (G6Pase) or lactate dehydrogenase (LDH) and glucose-6-phosphate dehydrogenase (G6PDH) were assayed from liver and brain homogenates respectively. Acute intranasal but not intraperitoneal insulin elevated brain insulin after 30 min. In animals administered single dose of 10 mg/kg dexamethasone, intranasal and intraperitoneal insulin lowered blood glucose within one hour. However, only the former’s effect was maintained at the 3rd and fourth hour. Dex-induced hyperglycemia was associated with increased hepatic glucose-6-phosphatase activity and decreased high-density lipoprotein (HDL), these effect were attenuated by subchronic (INI) administration. Also INI did not induce oxidative stress in the brain which suggests no brain damage during the period of study. Subchronic administration of INI was able to reduce the effect of Dex-induced hyperglycemia that is associated with increased hepatic glucose-6-phosphatase activity and decreased high-density lipoprotein (HDL) without damage to the brain. We demonstrate the potential of brain targeting with intranasal insulin in a rat model of insulin resistance and peripheral metabolic disease.
       
  • Evaluation of terpene-rich extract of Lantana camara L. leaves for
           antimicrobial activity against mycobacteria using Resazurin Microtiter
           Assay (REMA)

    • Abstract: Publication date: Available online 7 June 2018Source: Beni-Suef University Journal of Basic and Applied SciencesAuthor(s): Shriniwas P. Patil, Subhash T. Kumbhar BackgroundLantana camara L. (Verbenaceae) is notorious weed, leaves of which are rich in terpenes, in the form of essential oil. Terpenes have potent antimicrobial and antimycobacterial activities. Depending upon saponification characteristic of lipids and waxes; unsaponified petroleum ether extract which contain only terpenes, can be prepared. Terpene-rich extract (TRE) of L. camara L. leaves has exhibited higher antioxidant and antimicrobial activities as compared to any solvent extract.AimPresent attempt was aimed towards preparation of terpene-rich extract (TRE) of L. camara L. leaves; its phytochemical analysis by NMR and evaluation of its anti-mycobacterial activity.MethodsIn order to retain only terpenes in extract, in present study, petroleum ether extract of L. camara L. leaves was saponified using aqueous potassium hydroxide and remaining unsaponified extract (TRE) was phytochemically analyzed using chromatographic and NMR techniques. Further, TRE was screened for its anti-mycobacterial potential against Mycobacterium tuberculosis (H37Ra) by Resazurin Microtiter Assay (REMA) method.ResultsDetail phytochemical analysis reflected successful preparation of extract rich in terpenes. H1-NMR analysis proved the presence of various terpenes and triterpenoids, reported earlier for their presence in the plant. TRE was then found to have significant anti-mycobacterial activity with MIC90 value up to 50 µg/ml.ConclusionTRE contains different terpenes in specific proportion which makes it significantly potent antimycobacterial with minimum MIC90 value up to 50 µg/ml. REMA found to be economic and easier as compared to other techniques.Graphical abstractGraphical abstract for this article
       
  • Molecular detection of integron and antimicrobial resistance genes in
           multidrug resistant Salmonella isolated from poultry, calves and human in
           Beni-Suef governorate, Egypt

    • Abstract: Publication date: Available online 7 June 2018Source: Beni-Suef University Journal of Basic and Applied SciencesAuthor(s): Sahar A. Abdel Aziz, Gihan K. Abdel-Latef, Salama A.S. Shany, Sherin R. Rouby Antibiotic resistant Salmonella represent a public health threat worldwide. The current study was delineated to determine Salmonella spp. prevalent in poultry droppings (N: 14 flocks), calves feces (N: 90) and human stool samples (N: 80) from live-stock contacts as well as poultry handler in Beni-Suef governorate, Egypt. Phenotypic and genotypic screening for the presence of antimicrobial resistance was applied. Isolation rates were 57.1%, 5.6% and 2.5% for poultry, calves and humans, respectively. S. Megherafelt. S. Kentucky, S. Amsterdam, S. Nigeria, S. Paratyphi: B2, S. Alamo, S. Madras and S. Haifa were the predominant serovars in poultry flocks under investigation. The predominant serovar from calves’ samples was S. Kentucky while S. Infantis and S. Paratyphi: B2 were detected in human samples. The results of antimicrobial disc diffusion revealed the presence of multiple drug resistance (MDR) in100% of Salmonella isolates. PCR confirmed the existence of class 1 integron and the following gene cassettes in the resistant strains, blaTEM and blaSHV for β-lactams, aadA2 for aminoglycosides (streptomycin), tetA and tetB for tetracycline, sull for Sulfamethoxazole, dfrA for trimethoprim, floR for chloramphenicol and mphA for macrolides.
       
  • An analytical study of the performance indices of air spring suspensions
           over the passive suspension

    • Abstract: Publication date: Available online 7 June 2018Source: Beni-Suef University Journal of Basic and Applied SciencesAuthor(s): M.M. Moheyeldein, Ali M. Abd-El-Tawwab, K.A. Abd El-gwwad, M.M.M. Salem In terms of vehicle dynamics aspects, the suspension system should maintain good ride quality and road holding performance against the road irregularities especially in the case of high driving speeds. In this paper, two different air spring models (classic air spring; dynamic air spring model) are presented. Thereafter, both the dynamic air spring suspension and the passive suspension are compared in terms of RMS of body acceleration, suspension travel, and dynamic tire force. Based on that, a 2-DOF quarter mathematical model is implemented in MATLAB/Simulink platform. The ride quality and road handling responses are evaluated considering a vehicle speed of 20 m/s and road Class C. Besides, a parametric analysis is conducted to investigate the influences of the air spring model parameters on the vehicle dynamics. Then, the results are analyzed and compared for both the classic and dynamic air spring models showing the improvements over the passive suspensions. Furthermore, time domain and frequency domain analysis are then presented for the proposed suspensions. The obtained results indicated that, for the dynamic air spring model, the body acceleration, suspension travel and dynamic tire load improved by 27%, 10%, and 20%, respectively, which provides more comfort and easy handling performances comparing to the passive suspension.
       
  • Genotyping of β-lactams resistant staphylococci isolated from bovine
           subclinical mastitis

    • Abstract: Publication date: Available online 5 June 2018Source: Beni-Suef University Journal of Basic and Applied SciencesAuthor(s): Ahmed H. Abed, Al Sayed R. Attia, Ahmed A. Atia Staphylococci are one of the most significant causative mastitis pathogens in both clinical and subclinical cases. The present study aimed to study the prevalence of staphylococcal subclinical mastitis studying their antibiogram and detection of the prevalence mecA and blaZ genes in β-lactams resistant isolates using polymerase chain reaction (PCR). A total of 433 Staphylococcus species were recovered from 493 subclinically mastitic quarters with a prevalence of 87.8%. S. aureus were the most prevalent isolates as 237 isolates (48%). Also, 196 Coagulase-Negative Staphylococci (CNS) isolates (39.8%); representing 8 species, were recovered of which S. xylosus was the most predominant (36.7%), followed by S. epidermidis (14.8%), S. chromogenes (13.3%), S. haemolyticus (11.2%) and S. saprophyticus (9.7%). Results of antimicrobial susceptibility testing showed high resistances against ampicillin and cefoxitin while a moderate resistance was recorded against amoxicillin. PCR was applied on 40 β-lactam resistant Staphylococcus isolates (20 S. aureus and 20 CNS) for detection of mecA and blaZ genes. The two genes were detected in 75% and 65% of S. aureus isolates as well as in 70% and 55% of CNS isolates, respectively.
       
  • Mellein, a dihydroisocoumarin with bioherbicidal activity from a new
           strain of Lasiodiplodia pseudotheobromae C1136

    • Abstract: Publication date: Available online 4 June 2018Source: Beni-Suef University Journal of Basic and Applied SciencesAuthor(s): Charles Oluwaseun Adetunji, Julius Kola Oloke, Mishra Pradeep, A. Peter Oluyori, Ravinder Singh Jolly, Oluwasesan Micheal Bello The use of synthetic herbicides poses a serious threat to environment, health and food safety. The development of safe and effective bioherbicides for selective control of weeds is thus the primary concern in crop production around the world. Efforts are being made to investigate the use of a safe, ecofriendly and highly selective herbicides from biological origin. Coumarin and its derivatives are natural compounds renowned for their phytotoxic potential.Mellein, a dihydroisocoumarin designated as (R)-8-hydroxy-3-methylisochroman-1-one was isolated as an active metabolite from the broth of a new strain (this strain is one of the best among phytopathogenic strains collected) of Lasiodiplodia pseudotheobromae. The structural characterization of the compound was achieved by using combined spectroscopic analysis i.e. 1D and 2D NMR and LC–MS. The host range study was carried-out against plants from Cucurbitaceae, Solanaceae and Leguminosae, Poaceae and Valerianaceae families, the isolated phytotoxic metabolite from Lasiodiplodia pseudotheobromae at a concentration 10 µg/µl showed selective inhibition at 56%–66% against the latter two families only when inoculated.Hence, purified compound from Lasiodiplodia pseudotheobromae is recommended for large scale production of bioherbicides for the management of weeds in conventional farming to improve yield and enhance food security.
       
  • Molecular docking and quantitative structure-activity relationship study
           of anticonvulsant activity of aminobenzothiazole derivatives

    • Abstract: Publication date: June 2018Source: Beni-Suef University Journal of Basic and Applied Sciences, Volume 7, Issue 2Author(s): Usman Abdulfatai, Adamu Uzairu, Sani Uba In silico studies which include Quantitative structure-activity relationship (QSAR) and molecular docking studies were carried out on the 37 amino-benzothiazole derivatives (anticonvulsant agents). Genetic function approximation (GFA) of Material studio software version 8 was used to perform the QSAR study while Autodock vina version 4.0 of Pyrx software was used to perform the molecular docking of all the anticonvulsant agents. The high value of the correlation coefficient (R2) of 0.961 and the R2pred = 0.925 indicated that the model was satisfactory. Molecular docking analyses with Gamma-aminobutyric acid aminotransferases (GABAAT) revealed that aminobenzothiazole derivatives (anticonvulsant agents) with the best binding affinity was found to be −9.1 kcal/mol. The proposed model has good stability, robustness, and predictability on verifying with internal and external validation. The physicochemical parameters are to be considered when improving the inhibitory activities of the aminobenzothiazole derivatives against an enzyme that causes epilepsy (GABAAT).
       
  • Effect of health teaching on post partum minor discomfort

    • Abstract: Publication date: June 2018Source: Beni-Suef University Journal of Basic and Applied Sciences, Volume 7, Issue 2Author(s): Heba Talla El Ashmawy Shabaan, Yousria Ahmed El Sayed, Gehan Ghonemy BackgroundPostpartum period is a time of vast change for women both physically and psychologically. During this period, women needed to information regarding minor discomforts and how to deal with them.AimEvaluate the effect of health teaching on women experience of minor discomfort during postpartum period.DesignQuesi experimental (pre and posttest one group) design was selected for this study.SampleA convenience sample of 150 subjects was selected according to certain criteria.SettingPostpartum unit at Maternity University Hospital, Cairo Governorate.ToolSemi-structured Interviewing sheet, maternal knowledge regarding postpartum minor discomforts follow up tool.ResultsSubjects age ranged from 20 to 40 years with 44% completed secondary school education, 9.3% reached high level of education, also, the study conveyed a level of improvement regarding breast engorgement, after pain, urinary retention, constipation and episiotomy pain. Sixty-four point seven of subjects mention that they weren’t aware of expected minor discomforts during postpartum period before health teaching was given. After the teaching, only 0.7% of subjects were not aware of postpartum minor discomforts.ConclusionTeaching helped to improve the women’s knowledge regarding postpartum discomforts.RecommendationsHealth educational package on postpartum discomforts should be given on discharge should be written in clear and comprehensive explanation supported by drawing pamphlets especially for illiterate one.
       
  • Apoptotic efficiency of aqueous extracts of turmeric, garlic and their
           active compounds in combination with Tamoxifen in lung and oral cancers: A
           comparative study

    • Abstract: Publication date: June 2018Source: Beni-Suef University Journal of Basic and Applied Sciences, Volume 7, Issue 2Author(s): Satish Kumar Vemuri, Rajkiran Reddy Banala, Subbaiah GPV, Gurva Reddy AV, Malarvili Thekkumalai Anticancer treatment against oral and lung cancers has caught the eye of oncologist and researchers worldwide as most common cause deaths in India and worldwide is due to these cancers and most of the treatment strategies employed are not showing any effectiveness against neoplastic ability of the cancers. One of the reasons for cancer deaths could be because of poor prognosis and associated therapies. The existing cancer agents are being re-evaluated and development of new mechanisms of treatment being explored continuously, but it’s inadequate in offering treatment. Therefore, endeavors for new anticancer agents with high efficacy and considerable side effects still going on. The literature reviews shows numerous medicinal plants exhibiting anti-proliferative, pro-apoptotic, anti-metastatic and anti-angiogenic properties and these effects were reported by conducting both in vitro experiments and animal studies. Use of natural phytochemical compounds in cancer chemoprevention is an emerging strategy to forestall the cancer progression or cure cancer.In the present study we have attempted to evaluate the efficacy of Curcumin longa and Allium sativum aqueous extracts individually and in combination with its active compounds (Curcumin and Quercetin) and also with Tamoxifen hydrochloride. Our results suggest that aqueous extracts of Curcumin longa and Allium sativum were effective in inducing apoptosis and cell death in two immortal cell lines i.e. A549 and SCC-9 (Adeno carcinoma of lung, squamous cell carcinoma of tongue), but there was no apoptosis or cell senescence in normal cell line (HEK 293). There was significant increase in apoptosis and cell senescence in combination therapy. Hence a combination of natural extracts along with Tamoxifen can be considered an alternate in cancer treatments but this requires more research.
       
  • Discovery of potential visfatin activators using in silico docking and
           ADME predictions as therapy for type 2 diabetes

    • Abstract: Publication date: June 2018Source: Beni-Suef University Journal of Basic and Applied Sciences, Volume 7, Issue 2Author(s): Olusola Olalekan Elekofehinti, Oluwamodupe Cecilia Ejelonu, Jean Paul Kamdem, Oluwaseun Benedicta Akinlosotu, Ayodeji Famuti, Damilare Desmond Adebowale, Opeyemi Iwaloye, Yetunde Irinyemi Bulu, Ige Joseph Kade, Joao Batista Teixeira Rocha Visfatin (Nicotinamide phosphoribosyltransferase) is an adipokine implicated in mediating insulin resistance and exhibiting insulin mimetic effect and therefore represents a druggable target for diabetes therapy. About 3,844 peroxisome proliferator activated receptor gamma (PPARγ) agonists documented in Chembl database were docked with PPARγ and those with binding energy of>−9 kcal/mol having experimental EC50 of 0.1 to 1 nM were selected. The candidate compounds (27) were thereafter docked with visfatin (PDB ID: 4WQ6) using AutodockVina out of which eight compounds that ranked highest in binding energy (when compared with the co-crystallized ligand of visfatin: 3TQ) were selected. Compound 25 exhibited favorable ligand-protein molecular interaction and respected Lipinski’s rule of five and interestingly from the absorption, distribution, metabolism and excretion (ADME)-Toxicity analysis the compound have enhanced pharmacological properties than the current ligand of visfatin.
       
  • Effect of DPI's training-device on inhalation technique and clinical
           efficacy in asthmatics

    • Abstract: Publication date: June 2018Source: Beni-Suef University Journal of Basic and Applied Sciences, Volume 7, Issue 2Author(s): Mina Nicola, Ahmed A. Elberry, Ossama M. Sayed, Raghda R.S. Hussein, Mohamed E.A. Abdelrahim The aim of this work was to study the effect of using training device (In-Check DIAL) along with traditional dry powder inhaler (DPI) counseling on inhalation technique and pulmonary functions test (PFT) in asthmatics.Adult asthmatics>18 years old were recruited in 3months study of investigation and training. They were divided into control and investigation groups.DPI inhalation technique was checked and mistakes were noted and corrected at every monthly visit. Their peak expiratory flow and forced expiratory volume in 1second as percentage of forced vital capacity were checked at each visit followed by showing patients the correct inhalation technique and how to use In-Check DIAL (investigation group).29 patients (14 females) and 57 patients (30 females) in control and investigation groups respectively completed the study. Mean number of mistakes was significantly decreased (p 
       
  • Epidemiological determinants correlating hepatitis C and Schistosomiasis
           mansoni in one of Upper Egypt governorates

    • Abstract: Publication date: June 2018Source: Beni-Suef University Journal of Basic and Applied Sciences, Volume 7, Issue 2Author(s): Samah S. Abdel Gawad, Enas Yahia Abu-Sarea, Lamiaa Saleh Schistosomiasis and hepatitis C virus (HCV) are endemic diseases with high prevalence in Africa especially in Egypt. Many sociodemographic and behavioral related determinants were implicated to be associated with schistosomiasis, HCV or coinfection. Recently, polymerase chain reaction (PCR) is used as a diagnostic tool as it is a sensitive and a specific method especially in early stage of infection. But, diagnosis of S. mansoni is depending on microscopic examination remains the most widely used direct diagnostic method in endemic area. The current study was carried out to determine the prevalence of schistosomiasis mansoni, HCV and confection if any among the studied population, to identify any associated factors for schistosomiasis mansoni, HCV or coinfection if any.A descriptive cross sectional study was conducted on 400 participants, inhabitants in Beni-Suef Governorate, Upper Egypt. The studied population was screened for both schistosomiasis mansoni and HCV. They were subjected to fulfill a well-structured field tested interviewing questionnaire focusing on many suspected associated factors. Moreover, testing the performance characteristics of the used techniques was determined. The prevalence of schistosomiasis mansoni was (2.8%) and HCV was (42.5%) among the studied subjects. The study highlights on many behavioral and sociodemographic determinants significantly associated with HCV infection such as home crowding index, shaving at the community barber, sharing razors within the family, delivery at home and circumcision outside the health settings. Also, the study revealed that there are certain determinants associated with both schistosomiasis mansoni and HCV infection such as blood transfusion and liver cirrhosis. Studying the linked determinates with schistosomisis and HCV is the cornerstone to plan and implement a preventive strategy in the Upper Egypt. Thus, further studying the associated environmental determinants in relation to schistosoimasis, HCV and coinfection is recommended in the Upper Egypt.
       
  • Clinico-radiographic and histopathologic evaluation of iliac shaft
           fracture in dogs (an experimental study)

    • Abstract: Publication date: June 2018Source: Beni-Suef University Journal of Basic and Applied Sciences, Volume 7, Issue 2Author(s): M.Z. Fathy, G.H. Ragab, M.M. Seif, S.M. Gadallah, Salah Deeb, Nesreen M. Safwat The pelvic region has a great importance as it is the connecting ring between the hind limbs and the trunk as well as having special shape. The present study was conducted on 15 adult, mongrel male dogs aged 2–3 years and weighted 15–20 kg. Iliac shaft fracture was induced experimentally, and the fractured ilium was fixed by Dynamic Compatable Plate (DCP). Fracture healing was evaluated clinically, radiologically and histopahologically. The animals were partially-weight bearing on the limb of operated side 4th day post-operatively and they were full-weight bearing within 17th days post-operatively. The gait was varied from occasional lameness to full function at the 21–28th post-operatively. The results of this study was conducted along 16 weeks confirmed that the internal fixation for fractured ilium using a bone plate and screws had a good fixation and healing and all animals returned to normal gait within short time.
       
  • Isolation and molecular characterization of antifungal metabolite
           producing actinomycete from mangrove soil

    • Abstract: Publication date: June 2018Source: Beni-Suef University Journal of Basic and Applied Sciences, Volume 7, Issue 2Author(s): Mary Sulakshana Palla, Girija Shankar Guntuku, Murali Krishna Kumar Muthyala, Sirisha Pingali, Prafulla Kumar Sahu The main object of the present study is to isolate and characterize the actinomycetes from Koringa mangrove soil samples near Kakinada, Andhra Pradesh, India. Isolated actinomycetes were assessed for antagonistic activity against various bacteria and fungi. The potent strain KMFA-1 having activity against dermatophytes Candida albicans and Pectinotrichum llanense was characterized. Based on physiological, morphological characteristics and 16s rRNA gene sequencing the isolated strain was identified as Streptomyces hydrogenans. Extraction was done with different solvents and the activity was evaluated for each solvent extract. The antibiotic that is responsible for activity is found to be highly water soluble. The bioactive metabolite present in crude supernatant was found to be stable at 80 °C for 1 h, 90% activity was retained after boiling at 100 °C for 1 h, but 53.4% activity was reduced after autoclaving (at 121 °C for 15 min). The activity was not lost when the crude supernatant was subjected to wide range of pH (2–10). Furthermore, analytical techniques must be employed to isolate the molecule of interest. The result of present study revealed that the Streptomyces hydrogenans produced an interesting antifungal metabolite.
       
  • Development and screening of mutants from Monascus sanguineus for
           secondary metabolites production

    • Abstract: Publication date: June 2018Source: Beni-Suef University Journal of Basic and Applied Sciences, Volume 7, Issue 2Author(s): Rashmi Dikshit, Padmavathi Tallapragada Present study was carried out to develop a potent mutant for enhancing secondary metabolite production from Monascus sanguineus. Ultraviolet (UV) treatment as physical and Ethyl methane sulphonate (EMS) as chemical mutagen was used to cultivate the mutants. All obtained mutants were screened for growth and pigment yield on three different synthetic media namely; potato dextrose agar (PDA), malt glucose peptone agar (MGPA) and Czapek Dox yeast extract Agar (CDYA). MGPA media was found suitable for pigment yield whereas appreciable growth was observed with CDYA. Highest pigment yield was obtained for mutants developed at EMS concentration of 0.6 μg/μL (EMS-3) and UV exposed for seven minutes (UV-4). Exposure to UV for 11 min suppressed the pigment production. However this exposed strain (albino) was found to be an efficient producer of lovastatin with no traces of citrinin alike parental strain. Both EMS-3 and UV-4 mutants had synthesized negligible amount of citrinin, well below regulatory toxic levels. Significant variation was also noticed on the spore morphology of tested strains. Aleuroconidia was observed with albino strain whereas clestothesium along with pigmented ascospores were noticed with UV-4 and EMS-3 mutants. In a nutshell, these strains can be endorsed as nontoxic and safe for human consumption.
       
  • In vitro and in vivo anthelmintic activity of pumpkin seeds and
           pomegranate peels extracts against Ascaridia galli

    • Abstract: Publication date: June 2018Source: Beni-Suef University Journal of Basic and Applied Sciences, Volume 7, Issue 2Author(s): Amer R. Abdel Aziz, Mahmoud R. AbouLaila, Mohammad Aziz, Mosaab A. Omar, Khaled Sultan Pumpkin seeds (Cucurbita pepo) and Pomegranate peel (Punica granatum) have anthelmintic properties. The aim of this study was to compare the anthelmintic efficacy of pumpkin seeds ethanolic extract and pomegranate peel aqueous extract against Ascaridia galli in vitro and in vivo in Baladi chicks. On adult worms, the extracts of the two herbs were compared in vitro at concentrations of 25, 50, and 75 mg/ml with fenbendazole at a concentration of 5 mg/ml. Chicks were infected with Ascaridia galli eggs containing second stage larva and treated with 2000 mg/kg of each of the extracts compared with 100 mg/kg fenbendazole. In vitro, all concentrations of pumpkin seed extract and the concentration of 75 mg/ml pomegranate peel extract exhibited a nearly similar effect to fenbendazole. In vivo, the mortality rate of the worms extracted from the 2000 mg/kg pumpkin seeds extract-treated chicken was non-significantly different from that of fenbendazole for 48 h. While pomegranate peels extract exhibited a lower lethal effect than fenbendazole. The anthelmintic efficacy was dependent on time and concentration. The study presented the anthelmintic efficacy of the pumpkin seeds and pomegranate peel extracts on Ascaridia galli. Pumpkin seed extract was more effective than pomegranate peel extract. Future studies to determine the optimal dose to maximize their effectiveness especially for pumpkin seeds as anthelmintic therapeutic are required.
       
  • The protective effect of grape seed and Ginkgo biloba against
           hepatotoxicity induced by the antidysrhythmic drug “amiodarone” in
           male albino rats

    • Abstract: Publication date: June 2018Source: Beni-Suef University Journal of Basic and Applied Sciences, Volume 7, Issue 2Author(s): Manal Abdul-Hamid, Sanaa Reda Galaly, Hanaa Mahmoud, Fatma Mostafa Amiodarone was an orally effective antiarrhythmic drug widely used throughout the world, had long-term administration side effects such as hepatotoxicity. The actions of two antioxidants; grape seed and Ginkgo biloba on the extent of tissue damage in amiodarone-induced hepatotoxicity were elucidated in this study. We equally divided thirty-six albino rats into six groups given doses by gastric tube daily for 8 weeks as follow; the 1st group (G1) served as an untreated control group under the same laboratory conditions and was given distilled water, the 2nd group (G2) grape seed-treated group that received (100 mg/kg/day), the 3rd group (G3)Ginkgo biloba-treated group that received (100 mg/kg/day), the 4th group (G4) amiodarone-treated group that received (40 mg/kg/day), the 5th group (G5) received amiodarone parallel with grape seed at the same time and the 6th group (G6) received amiodarone parallel with Ginkgo biloba at the same time. The current histological study revealed that amiodarone caused marked change in the liver including degeneration, proliferation of bile duct, inflammatory cells infiltration and fatty changes of hepatocytes in addition to deposition of collagen fibers in the hepatic tissue moreover, ultra-structural observations in the liver including vacuolation, fibrosis and pyknotic nuclei. In addition, histochemical study revealed depletion of glycogen and comet assay revealed marked of DNA damage.Treatment with the two used antioxidants reduced the extent of liver damage induced by amiodarone as indicated by decreased Aspartate aminotransferase (AST) and Alanine aminotransferase (ALT) activities. These antioxidants ameliorated the histopathological, histochemical and ultrastructure alternations of the liver tissue. In conclusion, grape seed was markedly effective than Ginkgo biloba in protecting rats against amiodarone.
       
  • Uncommon clinical presentation of oral malignant melanoma

    • Abstract: Publication date: June 2018Source: Beni-Suef University Journal of Basic and Applied Sciences, Volume 7, Issue 2Author(s): Maha M Mahmoud, Marwa Madi, Raneem Gamal Malignant melanoma is one of the most lethal skin cancer due its high capability for metastasis. Its incidence has shown a dramatic increase over the past few decades. Primary oral melanoma is uncommon neoplasm, it can be present at any site in the oral cavity, with more frequent occurrence at the hard palate and maxillary alveolar mucosa. The prognosis of primary oral melanoma is extremely poor especially in advanced stage. The case presented here provides an example of how dental clinician have a major role in identifying malignant melanoma in any suspicious proliferating interdentally originated mass with partially pigmented area.
       
  • Preliminary cephalometric study of the relationship between facial
           morphology and sex

    • Abstract: Publication date: June 2018Source: Beni-Suef University Journal of Basic and Applied Sciences, Volume 7, Issue 2Author(s): Alhassan Kadri, Williams Kweku Darkwah, Abaidoo Chrissie Stassie, Gideon Aidoo, Atuahene Ohene-Djan Morphology of the face depends on many factors, such as sex, ethnicity, race, climate, nutrition, genetic constitution and socio-economic status. In the developed countries, there is well established database on facial anthropometry and for the purpose of identification. In Ghana however, there is very little documented information on cephalometric indices for biometric and forensic purposes. This study therefore, aimed at establishing baseline data to assess the relationship between sex using upper, lower and total cephalometric indices. One hundred participants made up of sixty males and forty females from KNUST were recruited for the study. Linear facial anthropometry were taken using calibrated Shahe digital calipers whiles participants sat with head in natural position. The facial anthropometric measurements were generally higher in males than in females. Upper facial height, facial width, nasal width, biocular diameter, lower facial height, lip length and total facial height were statistically significant and (p 
       
  • Production of new rhamnolipids Rha C16-C16 by Burkholderia sp. through
           biodegradation of diesel and biodiesel

    • Abstract: Publication date: Available online 24 May 2018Source: Beni-Suef University Journal of Basic and Applied SciencesAuthor(s): A.B. Abeer Mohammed, Ahmed A. Tayel, Nihal M. Elguindy Burkholderia sp. C3 was previously isolated from polycyclic aromatic hydrocarbons (PAH) contaminated soil; it was evaluated for the ability to utilize a range of diesel and biodiesel as sole carbon sources. Burkholderia sp. C3 could degrade 99% of diesel and biodiesel supplemented at 2% (v/v) in a basal mineral medium within 3 days of incubation at 30 °C. The produced rhamnolipids (RL), from diesel degrading bacteria, were characterized by Orcinol test and Mass spectrometry (MS). The MS confirmed that RLs structure compounds had a mixture of mono-rhamno-mono-lipidic, mono-rhamno-di-lipidic and di-rhamno-di-lipidic congeners. Burkholderia sp. produced a mixture of rhamnolipid homologues, as identified by mass spectrometry, while the composition of rhamnolipids depended upon the carbon substrates. The homologues rhamnolipid Rha-Rha-C10-C10, Rha-C10-C10 and Rha-Rha-C12-C12 were the predominant structures. Rha-C12-C14, Rha-C10-C12, Rha-Rha-C10-C12, and Rha-Rha-C12-C14 were detected as minor components. The efficient employment of Burkholderia sp., for the bioremediation of diesel contamination and production of RLs from it, could be recommended from this study.
       
  • Effect of different sterilization methods on physicochemical and
           microbiological properties of rice wine during the preservation

    • Abstract: Publication date: Available online 9 May 2018Source: Beni-Suef University Journal of Basic and Applied SciencesAuthor(s): Tie-Yan Jin, Kandasamy Saravanakumar, Myeong-Hyeon Wang The present study investigated the effect of three different sterilization methods (high hydrostatic pressure sterilization, ultraviolet sterilization and ultra-high temperature sterilization) on changes of physicochemical and microbiological properties of rice wine Makgeolli during the preservation at 15°C for 20 weeks. The results indicated that pH, titratable acidity, color, contents of reducing sugar and alcohol were not significantly varied between different sterilization methods but microbial counts and sensory evaluation were exhibited the significant differences. The microbial counts of the sterilized Makgeolli were significantly lower than that in unsterilized one after 20 weeks of storage. Sensory profiles were markedly dependent on the sterilization methods. This work inferred, the high hydrostatic pressure treatment as the suitable method of sterilization for improving the shelf life of rice wine Makgeolli.
       
  • Biological and phytochemical studies of different leaves extracts of
           Pteropyrum scoparium

    • Abstract: Publication date: Available online 8 May 2018Source: Beni-Suef University Journal of Basic and Applied SciencesAuthor(s): Afaf Mohammed Weli, Samiya Al-Salmi, Horiya Al Hoqani, Mohammad Amzad Hossain Pteropyrum scoparium (P. scoparium, Sidaf) is a medicinally important plant available in most of the tropical countries including Sultanate of Oman and locally it is used to treat dyspepsia and blood purifying agent. The aim of the present study is to prepare leave extracts of different polarities and to evaluate their phytochemicals, total phenols content, antioxidant and antimicrobial activities. The leaves of the plant were extracted with absolute ethanol by maceration method at ambient temperature for one week. The extract was filtered and evaporated to dryness by using rotary evaporator. The residue was suspended in equal volume of ethanol: water and fractionation with hexane, chloroform, and butanol, respectively. The total phenols content, antioxidant and antimicrobial activities of four prepared extracts were evaluated by Folin-Ciocalteu reagent (FCR), 2,2-diphenyl-1-picrylhydrazyl (DPPH) and agar disc diffusion methods. The highest amount of phenols content was found in hydro alcoholic extract and the lowest content was in hexane to be in the order of hydro alcohol > butanol > chloroform > hexane extract. The main antioxidant activity was found in residue from butanol and the minimum activity was in that from chloroform, the order of antioxidant activity; butanol > hydro alcoholic > hexane > chloroform extract. The antibacterial activity of ethanol extract and its derived fractions of the plant against one Gram-positive Staphylococcus aureus (S. aureus) and one Gram-negative Escherichia coli (E. coli) bacteria strains were qualitatively assessed by the presence or absence of inhibition zones. All the extracts of the selected plant at most of the concentrations did not exhibit potent antibacterial activity. The phytochemical studies of the prepared extracts, showed that all the extract contains saponins, steroids, and terpenoids. In addition to that, the chloroform, butanol and hydro-alcohol extract contains tannins and glycoside. In conclusion, all the crude extracts showed significant antioxidant activity. It could be used as natural antioxidant instead of synthetic one.
       
  • Spectrophotometric and tandem mass spectroscopic analysis of Indian borage
           (Plectranthus amboinicus (Lour.) Spreng.) for its polyphenolics
           characterization

    • Abstract: Publication date: Available online 26 April 2018Source: Beni-Suef University Journal of Basic and Applied SciencesAuthor(s): C.T. Sulaiman, M. Deepak, Indira Balachandran Plectranthus amboinicus (Lour.) Spreng. has been used for the treatment of many diseases in traditional Indian systems of medicine. In the present study, Polyphenolic profiling was carried out in leaves of P. amboinicus using spectrophotometric and mass spectroscopic analyses. The total Polyphenolics of different extracts such as ethanol, acetone and n-butanol were estimated spectrophotometrically and major phenolic compounds of ethanol extract was characterized by HPLC coupled tandem mass spectroscopic analysis.
       
  • Central composite design for optimization of preparation conditions and
           characterization of hydroxyapatite produced from catfish bones

    • Abstract: Publication date: Available online 26 April 2018Source: Beni-Suef University Journal of Basic and Applied SciencesAuthor(s): Farombi Abolaji Grace, Amuda Omotayo Sarafadeen, Alade Abass Olanrewaju, Okoya Aderonke, Olayiwola Olusegun Akeem, Adebisi Segun Akanmu Hydroxyapatite (HAP) was prepared from catfish bones at optimized conditions by employing Central Composite Design (CCD) under Response Surface Methodology (RSM). The temperature of preparation ranges between 300 and 1000 °C and time was varied between 1 and 2 h. The software gave thirteen (13) runs experiment within the conditions. 10 g of treated catfish bones inside crucible was calcined in the furnace at the temperatures and times suggested by the software. The yield percentages were determined and a standard method of pore size estimation Methylene Blue Number Method was used to estimate the adsorption capacity of the calcined catfish bones (CFHAP). Hence, the optimized conditions for adsorption were deduced. Characterization of the catfish bones before and after calcinations was studied by using Scanning Electron Microscopy (SEM); Fourier Transform Infrared Spectroscopy (FTIR;) Energy Dispersive X –ray Spectroscopy (EDX) and Brunaver-Emmett-Teller (BET). The results confirmed that the product is hydroxyapatite.
       
  • l-cysteine+derivatives+as+multi-target-directed+ligands+for+the+treatment+of+neurodegenerative+diseases&rft.title=Beni-Suef+University+Journal+of+Basic+and+Applied+Sciences&rft.issn=2314-8535&rft.date=&rft.volume=">Design synthesis in silico in vitro and in vivo evaluation of novel
           l-cysteine derivatives as multi-target-directed ligands for the treatment
           of neurodegenerative diseases

    • Abstract: Publication date: Available online 19 April 2018Source: Beni-Suef University Journal of Basic and Applied SciencesAuthor(s): Vadivel Kannan, Manohar Babu Sitty, Muthusamy Periyannan There are four major molecular mechanisms involved in the neuronal cell death are excitotoxicity, neuroinflammation, apoptosis and oxidative stress. Our objective is to explore in silico, in vitro and in vivo evaluation of neuroprotective potential of novel l-Cysteine derivatives as multi-target-directed drugs to manage neurodegenerative diseases. Fifty molecules were designed and included in the in silico analysis to evaluate their druglikeness and binding affinities towards the selected target proteins using various pharmacokinetic and docking software. Based on in silico results and synthetic feasibility, nine compounds were selected for synthesis, spectral analysis, in vitro and in vivo neuroprotective evaluation on neuroblastoma cell line and aluminium induced neurotoxicity in rats. Selected compounds gained best docking score and obey Lipinski’s rule of five. In vitro results showed that the compound 1a and 1b significantly increased the percentage viability (81.03 ± 4.78 and 76.1 ± 1.99) of human neuroblastoma cells at concentration of 100 µg. Mean retention latencies and oxidative stress were significantly decreased (P 
       
  • Three-dimensional finite element analysis of a porcelain crowned tooth

    • Abstract: Publication date: Available online 17 April 2018Source: Beni-Suef University Journal of Basic and Applied SciencesAuthor(s): Bankole.I. Oladapo, S. Abolfazl Zahedi, F. Vahidnia, O.M. Ikumapayi, Muhammad U. Farooq The restoration of endodontically treated teeth is one of the main challenges in restorative dentistry since the weakened tooth structure is more prone to biomechanical failures due to significant tooth loss. The aim of this paper is to computational analysis of prepared crowned tooth in order to differentiate the possibility of using porcelain material for typical clinical condition and masticatory load by using the three-dimensional finite element method (3D FEM). In order to have an accurate geometry of tooth model, a coordinate measuring machine (CMM) is proposed to scan the tooth. The obtained scanned contours exported to ABAQUS FE package for computational stress analysis. The prosthodontics crown FEM has been created and put on simulated chewing stresses. The model is composed of four different materials, namely; prepared tooth, luting cement, substructure (IPS Empress Core), and Ingot (IPS Empress Layer). The generated FEM run and the stress distributions of the crowned tooth is thoroughly investigated. The developed model is extremely useful for indicating tooth biomechanics and has the tendency to deliver a better understanding to designers in the biomedical engineering field and dentistry.
       
  • Microwave-assisted extraction and characterization of fatty acid from eel
           fish (Monopterus albus)

    • Abstract: Publication date: Available online 17 April 2018Source: Beni-Suef University Journal of Basic and Applied SciencesAuthor(s): Haruna Kolawole Afolabi, Siti Kholijah Abdul Mudalip, Oluwaseun Ruth Alara Eel fish (Monopterus albus) is a functional food that has shown remarkable effects on a range of diseases, which include inflammatory diseases, type 2 diabetes and cancer. This study emphasized on the use of microwave-assisted extraction (MAE) technique in studying the effects of three MAE parameters (irradiation time, microwave temperature and microwave power) to obtain extract from eel fish using ethanol as the extracting solvent. The free fatty acid (FFA), acid value, fatty acid contents, and functional groups in the extract were also examined. More so, the maximum extraction yield of 16.13% w/w was obtained at a microwave power of 800 W, FFA and acid value of 1.35 and 2.69 mg KOH/g, respectively confirmed good quality of the obtained extract. In addition, the major fatty acid contents in the extract using gas chromatography-mass spectrometry (GC-MS) analysis were arachidonic acid, linolenic acid, myristic acid, oleic acid, palmitic acid, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA). Consequently, the Fourier transform infrared spectrometry (FTIR) analysis confirmed the presence of different functional groups in the extract. Therefore, this study divulged that MAE is an efficient and reliable technique for extracting high yields of fatty acids from M. albus fish with a notable potential for industrial applications.
       
  • An evidence of fungal derived 1-aminocyclopropane-1-carboxylate deaminase
           promoting the growth of mangroves

    • Abstract: Publication date: Available online 7 April 2018Source: Beni-Suef University Journal of Basic and Applied SciencesAuthor(s): Kandasamy Saravanakumar, Davoodbasha MubarakAli, Kandasamy Kathiresan, Myeong-Hyeon Wang The present study reports the enzyme 1-aminocyclopropane-1-carboxylate deaminase (ACCD) from Trichoderma strains TSK8 and SKS1 enhance the growth mangroves (Rhizophora) evidenced by primary enzyme quantification followed by greenhouse experiments. The results indicated that ACCD enzyme activity about 20% higher in strain SKS1 than that of strain TSK8. In the greenhouse study, we analyzed the effect of Trichoderma treatment on physiological and biochemical characteristics of mangrove seedlings. The results demonstrated that SKS1 significantly enhanced the growth of mangroves (Rhizophora apiculata and Rhizophora mucronata) as compared to control (untreated). The strain TSK8 and SKS1 increased the plant total biomass by 43.26% and 41.23% respectively in R. mucronata. Particularly, SKS1 showed the 70.8% biomass increase in R. apiculata. The growth was investigated with and without the addition of soluble phosphate were investigated. Thusly, the fungal strains SKS1 and TSK8 derived ACCD has potency on the mangroves growth enhancement. Thus present work provided the platform for the development of Trichoderma sp. based biofertilizer for a promising approach for the restoration of aquatic plants.
       
  • Design regulatory interaction network for anxiety disorders using R: A
           bioinformatics approach

    • Abstract: Publication date: Available online 6 April 2018Source: Beni-Suef University Journal of Basic and Applied SciencesAuthor(s): Nahida Habib, Bikash Kumar Paul, Md. Shadidul Islam, Kawsar Ahmed Bio-informatics research fields are progressively growing enriched with the incremental use of R tools. Anxiety Disorders can be defined as one of the most common mental disorders. They are tangible psychiatric disorders or a group of mental illnesses thought to be caused by either genetic vulnerability or environmental susceptibility factors. Several studies have revealed that anxiety is associated with an increased risk of Angina, Asthma, Diabetes, Heart Attack and High Blood Pressure. Thus, these five anxiety disorders must have some genetic association among them. Finding the genetic relationship among the above diseases will help to understand the gene linkage and connection association among them which leads to the way to common drug design. Here, after investigating the genetic association of Angina, Asthma, Diabetes, Heart Attack and High Blood Pressure a Regulatory Interaction Network is designed using R. The investigated diseases genes are collected, preprocessed, processed, mined and optimized using R. This research aimed to create a new dimension in the field of drug design.
       
  • Efficient extraction of antioxidants from Vernonia cinerea leaves:
           Comparing response surface methodology and artificial neural network

    • Abstract: Publication date: Available online 28 March 2018Source: Beni-Suef University Journal of Basic and Applied SciencesAuthor(s): Oluwaseun Ruth Alara, Nour Hamid Abdurahman, Haruna Kolawole Afolabi, Olusegun Abayomi Olalere Despite response surface methodology (RSM) has been the most preferred statistical tool for optimizing extraction processes, artificial neural network (ANN) has been one of the most effective tools used for optimization and empirical modelling since the last two decades, most especially for non-linear equations. Thus, this study was carried out to compare the performance of RSM and ANN in optimizing the extraction yield and antioxidant capability of extract from Vernonia cinerea leaves using microwave-assisted extraction (MAE) techniques. The responses (extraction yield and antioxidant capabilities) were modelled and optimized as functions of four independent MAE parameters (irradiation time, microwave power level, ethanol concentration, and feed-to-solvent ratio) using RSM and ANN. The coefficient of determination (R2), root mean square error (RMSE) and absolute average deviation (AAD) were employed to compare the performance of both modelling tools. ANN model has a higher predictive potential compared to RSM model with higher correlation coefficients of 0.9912, 0.9928 and 0.9944 for extraction yield, DPPH and ABTS scavenging activities, respectively. Thus, ANN model could be a better alternative in data fitting for the MAE of antioxidants from Vernonia cinerea leaves.
       
  • Design and assessment of pulsatile technology based chronomodulated
           delivery systems of nifedipine

    • Abstract: Publication date: Available online 26 March 2018Source: Beni-Suef University Journal of Basic and Applied SciencesAuthor(s): Sowjanya Battu, Prasanna Raju Yalavarthi, G.V. Subba Reddy, V. Uma Maheswara Rao, K. Jyothshna Devi, Harini Chowdary Vadlamudi Nifedipine has poor aqueous solubility which limits its oral absorption as unit formulation. This limitation was acted through multiparticulate pulsatile systems for the treatment of angina pectoris. Initially, solid dispersions of nifedipine (NF) using sodium starch glycolate (SSG) and guar gum (GG) in 1:1 and 1:2 ratios were processed by kneading technique. Solution layering technique was employed to coat the solid dispersions on non-pareil sugar spheres (∼450 µm) to obtain immediate (NMP 1 and 2) and controlled release pellets (NMP-3 and 4). Controlled release pellets were further coated with Eudragit L100 and RS100 to achieve pulsatile pellets (NMPP-1 to 5). Pellets were subjected to saturation solubility, FTIR, DSC, micromeritics, SEM, drug content, drug release, pharmacokinetic and stability studies. By means of solid dispersions, solubility of NF was increased by 130-folds due to encompassing ordered interparticle mixing of NF and carriers. Significant interactions between NF and carriers were not demonstrated in FTIR spectra as well as in DSC thermograms. Fluidization process again proved its supremacy in producing defined spherical shaped pellets with desired micromeritics. Solution layering process resulted with high drug content (81–94.2%) and maximum drug was released by end of 12 h with 6 h lag phase. Suitable pharmacokinetic parameters were moderated by immediate (NMP) and pulsatile pellets (NMPP) as Cmax of 820 ng/mL for NMP-2 and 360.8 ng/mL for NMPP-5 at 5 and 16 h respectively. Increased pharmacokinetics and bioavailability were the result of linear increase in solubility of NF with solid dispersions. The pulsatile formulations were physicochemically intact over a period of time. Thus, multiparticulate systems of NF had demonstrated their applicability in chronotherapy of circadian based ailments.
       
  • Interplay of electrically conducting and non conducting walls on
           magnetohydrodynamic mixed convection flow in vertical permeable
           micro-channel in existence of induced magnetic field

    • Abstract: Publication date: Available online 26 March 2018Source: Beni-Suef University Journal of Basic and Applied SciencesAuthor(s): Basant K. Jha, Babatunde Aina In this article, flow formation of fully developed mixed convection flow of an incompressible, viscous and electrically conducting fluid in vertical permeable micro-channel in presence of induced magnetic field is analyzed. The effects of velocity slip and temperature jump are taken into account. The influence of induced magnetic field arising due to the motion of an electrically conducting fluid in the presence of transverse magnetic field is taken into consideration. The governing equations of the motion are a set of simultaneous ordinary differential equations and their exact solutions in dimensionless form have been obtained for the velocity field, the induced magnetic field and the temperature field. The expressions for the induced current density and skin friction have also been obtained. Numerical procedures are examined for various active parameters namely: suction/injection, rarefaction, fluid wall interaction, mixed convection, Hartmann number and the magnetic Prandtl number. Results revealed that, increase in Hartmann number and magnetic Prandtl number causes a pronounced reduction in skin friction.
       
  • Optimization of the anticonvulsant activity of
           2-acetamido-N-benzyl-2-(5-methylfuran-2-yl) acetamide using QSAR modeling
           and molecular docking techniques

    • Abstract: Publication date: Available online 24 March 2018Source: Beni-Suef University Journal of Basic and Applied SciencesAuthor(s): Oluwaseye Adedirin, Adamu Uzairu, Gideon A. Shallangwa, Stephen E. Abechi Chemometric descriptors were used to analyze quantitatively the anticonvulsant activity of ninety propanamide derivatives. Molecular geometries of the data set were optimized with B3LYP/6-31G∗∗ quantum mechanical method and chemometric descriptors were calculated from the optimized structure. Linear QSAR models were developed using genetic function algorithm. Predictive capabilities of the models were evaluated using various internal and external validation techniques. The best three models proposed were octa-parametric equation with good statistical quality: R2 (0.898–0.918); Q2 (0.865–0.893); R2pred (0.746–0.772) and F (66.657–88.036). 2-acetamido-N-benzyl-2-(5-methylfuran-2-yl) acetamide a member of the data set was chosen as scaffold for in silico design. Using the information afforded by the models, several attempts were made to optimize the scaffold by introducing various modifications. Potential derivatives with higher predicted activity values than the template were identified and a detailed analysis on the models applicability domain defined the designed compounds, whose estimations can be accepted with confidence. Some of the designed compounds docked with γ-aminobutyrate aminotransferase (PBD: 1OHV) (target) showed better binding affinity for the target when compare with 4-aminohex-5-enoic acid (vigabatrin) (a known inhibitor of the target).
       
  • Morphological, histological and ultrastructural studies on the exocrine
           pancreas of goose

    • Abstract: Publication date: Available online 22 March 2018Source: Beni-Suef University Journal of Basic and Applied SciencesAuthor(s): Rasha Ragab Beheiry, Waheed Abdel-Azeem Abdel-Raheem, Ahmed Mostafa Balah, Hoda Foad Salem, Mayada Wahid Karkit The present work was aimed to study the morphological and histological features of goose pancreas and to investigate the ultrastructure of pancreatic acini. This study was conducted on the pancreas of ten healthy mature birds of goose. The pancreas was excised from the duodenum rapidly after slaughter of the birds. The specimens were fixed in 10% buffered neutral formalin then processed for light and electron microscopic study. The macroscopic observations revealed that goose pancreas was located in the right side of the abdomen between the ascending and descending loops of duodenum. It was formed from dorsal, splenic, ventral and third lobes. The histological observations revealed that the pancreas was formed of lobules of serous acini. The secretory acinus unit was appearing as a single spherical mass composed of many serous cells surrounding narrow lumen. The pyramidal acinar cells appeared bizonal structure; the basal basophilic cytoplasm and apical acidophilic cytoplasm. Centroacinar cells were slightly smaller cells that appeared brighter than the acinar cells and were located in the center of the lumen of the acinus. The duct system was well developed began with the centroacinar cells. Underneath electron microscope, the acinar cells have been two kinds, the electron dense acinar cells with electron dense cytoplasm and heterochromatic nuclei and the electron lucent acinar cells, which characterized by means of electron lucent cytoplasm, and their nuclei had considerable euchromatin, abundant endoplasmic reticulum, mitochondria and numerous zymogen granules, and considered active cells.
       
  • Variation in seasonal prevalence and intensity of progenetic metacercariae
           of Clinostomum complanatum infection in Trichogaster fasciatus fish

    • Abstract: Publication date: Available online 19 March 2018Source: Beni-Suef University Journal of Basic and Applied SciencesAuthor(s): Shabnam Khan, Sakil Ahmed, M. Serajuddin, Mohammad Khalid Saifullah A total of 1242 out of 1484 Trichogaster fasciatus fish were found to be infected with metacercarial stage of Clinostomum complanatum where 14,258 parasites were recorded mainly from the peritoneal cavity, gills and viscera during five years of study period. The seasonal variations in prevalence, intensity and abundance of the parasitic infection were assessed. The maximum and minimum values of prevalence of metacercarial infection of C. complanatum in the fish were 92.40% and 70.40% during summer and winter respectively. Similarly, intensity and abundance of the parasite were maximum during summer as compared to winter and rainy seasons. The high prevalence of infection of the parasite during summer may be because of the time of emergence of cercariae in high temperature from snail vector and the environment.
       
  • Water demand and waste management with respect to projected urban growth
           of Gurugram city in Haryana

    • Abstract: Publication date: Available online 17 March 2018Source: Beni-Suef University Journal of Basic and Applied SciencesAuthor(s): Anil Kumar Misra, Misbah Masoodi, Rohith P. Poyil, Naval Kishore Tewari Gurugram city (Haryana state) has witnessed unprecedented urban growth over the past two decades, owing to the escalation in population, immigration and unorganized expansion. Present study examines the spatial determinants and different features of urban growth till 2011 in the Gurugram city and based on the growth rates and probable demands, land use pattern changes for 2031, 2041 and 2051 have been projected. Using photogrammetric analysis, orthoimage of Gurugram city was prepared and through visual image interpretation land use map of Gurugram city was generated. The population escalation was calculated using population estimation method and land use pattern of Gurugram city was predicted for 2031, 2041 and 2051. Based on the land cover and land use pattern changes, strategies for managing the water resource and solid waste management have been proposed. Probable future changes in land cover patterns, urban growth and land use patterns are very useful for urban planning and managing the natural resources. The results of the study could help in understanding the urban growth processes and their patterns, and facilitate urban planners and policy makers to deal with rapid urban agglomeration processes and associated problems.
       
  • Amelioration of DENA-induced oxidative stress in rat kidney and brain by
           the essential oil of Elettaria cardamomum

    • Abstract: Publication date: Available online 15 March 2018Source: Beni-Suef University Journal of Basic and Applied SciencesAuthor(s): Nihal M. Elguindy, Galila A. Yacout, Eman F. El Azab The goal of the present work was to study the protective role of the essential oil of Elettaria cardamomum (cardamom) against diethylnitrosamine (DENA)-induced oxidative stress in the kidney and brain of rats in comparison with geraniol, a pure compound as one of the main components of cardamom essential oil. Geraniol or cardamom essential oil was orally administered every day (100 and 200 mg/kg) for 1 week before DENA administration and continuously administered for 26 weeks. The levels of brain and kidney ornithine decarboxylase (ODC), brain acetylcholinesterase (AChE) and renal markers such as urea and creatinine were elevated after DENA administration. However, cardamom and geraniol administration decreased kidney and brain oxidative stress and lowered the activity of ODC in brain and kidney and the activity of AChE in brain. Cardamom or geraniol had significantly reduced the level of lipid peroxidation to almost half the value in DENA group and enhanced glutathione level by double its values in brain and kidney compared to glutathione levels in DENA treated-rats. In addition, geraniol or oil of cardamom improved the activities of the antioxidant markers; catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase, and glutathione-S transferase in the brain and kidneys of DENA-treated rats. The results support the chemopreventive, antioxidant, neuroprotective and anticancer effects of the essential oil of cardamom, which are mediated through its inhibition of ODC and AChE activities and activation of antioxidant markers.
       
  • Seasonal and spatial variation of aquatic macrophytes and phytoplankton
           community at El-Quanater El-Khayria River Nile, Egypt

    • Abstract: Publication date: Available online 15 March 2018Source: Beni-Suef University Journal of Basic and Applied SciencesAuthor(s): Mostafa M. El-Sheekh, Amany M. Haroon, Soad Sabae In this study, the phytoplankton biomass and species composition in El-Quanater El-Khayria (River Nile, Egypt) was analyzed at four sampling sites on a program of a seasonally sampling and supported by measurements of different water variables as well as biomass production of most common aquatic macrophytes. The major species of aquatic macrophytes were two submerged species (Ceratophyllum demersum and Ceratophyllum submersum), two emergent (Polygonum tomentosum and spontaneum), and one free floating aquatic macrophyte (Eichhornia crassipes). Considerable seasonal variations in water quality as well as macrophytes biomass were found in the studied areas, which result in a variation of phytoplankton flora. A total of 235 phytoplankton species belonging to 7 classes was recorded, with higher numbers in autumn and winter compared to spring and summer. The maximum number of phytoplankton (7238 × 104 L−1 cells) was recorded in winter, however, the lowest one (96 × 104 L−1 cells) recorded in spring. Chlorophyceae was the dominant group, forming 56.96% of the total phytoplankton biomass followed by Bacillariophyceae (34.82%), Cyanophyceae (7.99%), Cryptophyceae (0.10%), Dinophyceae (0.096%), Chrysophyceae (0.03%) and Euglenophyceae (0.02%). Chlorophyll a values ranged from 9.77 µg L−1 to 69.81 µg L−1, with a considerable seasonal and spatial variation. All phytoplankton classes as well as, chlorophyll a was negatively correlated with all aquatic macrophytes species except for C. submersum which correlated positively with chlorophyll a and Cyanophyceae. In addition, it was positively correlated with pH, conductivity and dissolved oxygen.
       
  • BNP as a promising marker in prediction of malignant arrhythmias in pts
           with LV systolic dysfunction after an acute MI

    • Abstract: Publication date: Available online 10 March 2018Source: Beni-Suef University Journal of Basic and Applied SciencesAuthor(s): Ahmed Yassin, MohamedAbo Hamila, Ahmed Battah, Amal Rizk, SheriefMokhtar
       
  • New insights into the medicinal importance, physiological functions and
           bioanalytical aspects of an important bioactive compound of foods
           ‘Hyperin’: Health benefits of the past, the present, the future

    • Abstract: Publication date: March 2018Source: Beni-Suef University Journal of Basic and Applied Sciences, Volume 7, Issue 1Author(s): Kanika Patel, Vikas Kumar, Mahfoozur Rahman, Amita Verma, Dinesh Kumar Patel Herbal medicines have been used for the treatment of various disorders in the world since very early age. A large number of phytochemicals have been derived from the natural sources in the form of food supplement, neutraceuticals, oils and colour pigments. Flavonoids are a widely distributed group of phytochemicals having benzo-pyrone nucleus. Till so far more than 4000 different types of flavonoids have been described and categorized into different groups like flavonols, flavones, flavanones, isoflavones, catechins and anthocyanidins. Flavonoids have an attractive candidate in the food industry as natural colorants due to its health beneficial effect and safety issue. Hyperin, an important flvonoid were found in the different plants have various pharmacological activities like antioxidant, anti-inflammatory, anticancer, antiviral, antibacterial, antiparasitic, cardioprotective, hepatoprotective and antispasmodic. The aim of this review is to collect all the valuable scientific information of hyperin regarding its medicinal importance, pharmacological activities, isolation and analytical techniques. From the presented data’s in this review it will be beneficial to the scientific person, pharmaceutical manufacturer and consumers in order to it health beneficial effect of hyperin. Thus this valuable information will be helpful to the researchers for developing alternative methods of treatment for different diseases.Graphical abstractGraphical abstract for this article
       
  • Vernonia amygdalina: A folkloric herb with anthelminthic
           properties

    • Abstract: Publication date: March 2018Source: Beni-Suef University Journal of Basic and Applied Sciences, Volume 7, Issue 1Author(s): Ifeoluwa T. Oyeyemi, Akinbiyi A. Akinlabi, Aderiike Adewumi, Abimbola O. Aleshinloye, Oyetunde T. Oyeyemi Vernonia amygdalina, a widely grown shrub plant in Africa is consumed as vegetable and has high medicinal value. It has gained wide application in the treatment and management of various diseases. The leaves are useful components for herbal medicine constitution. The plant’s activities is a result of diverse bioactive compounds isolated from the different parts of the plant. These metabolites have specifically been efficacious against parasites especially worms. The mechanisms of activities include paralysis of worm, interference with energy generation and impairment with nutrient absorption, motility, and reproduction. The lack of considerable toxicity associated with the plant makes it a choice for further drug discovery. Effort should be made towards standardizing the extract(s) of V. amygdalina for use in alternative medicine for treatment of helminth-related diseases.
       
  • Antileishmanial potential of medicinal plant extracts from the North-West
           of Morocco

    • Abstract: Publication date: March 2018Source: Beni-Suef University Journal of Basic and Applied Sciences, Volume 7, Issue 1Author(s): Abdelhakim Bouyahya, Abdeslam Et-Touys, Nadia Dakka, Hajiba Fellah, Jamal Abrini, Youssef Bakri The aim of this study is to evaluate the antileishmanial activity of selected medicinal plants from the North-West of Morocco. Plant extracts were prepared by maceration using methanol, ethanol, and n-hexane. The antileishmanial activity was evaluated against Leishmania major, Leishmania tropica, and Leishmania infantum using MTT (3-(4.5-dimethylthiazol-2yl)-2.5-diphenyltetrazolium bromide) assay. All plant extracts showed a reducing in cell promastigotes viability with variability depending on tested strains and type of extracts. The n-hexane extract showed the highest antileishmanial activity and L. infantum was the most sensitive parasite. The best growth inhibition was observed with Cistus crispus n-hexane extract against L. major (IC50 = 47.29 ± 2.25 μg/mL), Arbutus unedo n-hexane extract against L. infantum (IC50 = 64.05 ± 1.44 μg/mL) and Arbutus unedo n-hexane extract against L. tropica (IC50 = 79.57 ± 2.66 μg/mL). Considering these results, medicinal plants from the North-West of Morocco could constitute a promoter source for antileishmanial compounds.
       
  • Development and functionalization of magnetic nanoparticles as powerful
           and green catalysts for organic synthesis

    • Abstract: Publication date: March 2018Source: Beni-Suef University Journal of Basic and Applied Sciences, Volume 7, Issue 1Author(s): Ahmed M. Abu-Dief, Shimaa Mahdy Abdel-Fatah Magnetic nanoparticles are a highly worthy reactant for the correlation of homogeneous inorganic and organic containing catalysts. This review deals with the very recent main advances in the development of various nano catalytic systems by the immobilization of homogeneous catalysts onto magnetic nanoparticles. Catalytic fields include the use of mainly cobalt, nickel, copper, and zinc ferrites, as well as their mixed-metal combinations with Cr, Cd, Mn and sometimes some lanthanides. The ferrite nanomaterials are obtained mainly by co-precipitation and hydrothermal methods, sometimes by the sonochemical technique, micro emulsion and flame spray synthesis route. Catalytic processes with application of ferrite nanoparticles include degradation (in particular photocatalytic), reactions of dehydrogenation, oxidation, alkylation, C–C coupling, among other processes. Ferrite nano catalysts can be easily recovered from reaction systems and reused up to several runs almost without loss of catalytic activity. Finally, we draw conclusions and present a futurity outlook for the further development of new catalytic systems which are immobilized onto magnetic nanoparticles.
       
  • Antimicrobial and cytotoxic comparative study of different extracts of
           Omani and Sudanese Gum acacia

    • Abstract: Publication date: March 2018Source: Beni-Suef University Journal of Basic and Applied Sciences, Volume 7, Issue 1Author(s): Said Musallam Al Alawi, Mohammad Amzad Hossain, Ahmed A. Abusham Gum acacia, known as Gum Arabic in Oman is widely grown all over the tropical countries including Gulf region. The antimicrobial and cytotoxic activities of different polarity organic extracts of Omani and Sudanese Gum acacia latex has been investigated in this study using maceration method. Both Omani and Sudanese Gum acacia latex samples were used to prepare different fractions using various organic solvents. The antimicrobial activity of different organic extracts was determined through disc diffusion method against clinically isolated bacterial strains. The isolated pathogenic bacterial strain are Gram (+) Staphylococcus aureus (S. aureus, Code No. 659), Gram (−) Escherichia coli (E. coli, Code No. 846), Gram (−) Escherichia coli (E. coli, Code No. 683) and Gram (−) Klebsiella pneumoniae (Code No. 684). The antibiotic levofloxacin and dimethyl sulphoxide (DMSO) were used as positive and negative controls. The cytotoxic activity of the above mentioned organic extracts was determined by brine shrimp lethality method (BSL). Both latex samples of various polarity organic extracts at different concentrations showed antimicrobial activity against the isolated human bacterial strains with an inhibition range of 0–15 mm. However, both latex samples did not reveal a significant cytotoxic activity at any concentration. In conclusion, the organic extracts from both types of Gum acacia (Omani and Sudanese) represent a good source of natural antibiotic for the treatment of various infectious diseases.
       
  • A fuzzy logic based PROMETHEE method for material selection problems

    • Abstract: Publication date: March 2018Source: Beni-Suef University Journal of Basic and Applied Sciences, Volume 7, Issue 1Author(s): Muhammet Gul, Erkan Celik, Alev Taskin Gumus, Ali Fuat Guneri Material selection is a complex problem in the design and development of products for diverse engineering applications. This paper presents a fuzzy PROMETHEE (Preference Ranking Organization Method for Enrichment Evaluation) method based on trapezoidal fuzzy interval numbers that can be applied to the selection of materials for an automotive instrument panel. Also, it presents uniqueness in making a significant contribution to the literature in terms of the application of fuzzy decision-making approach to material selection problems. The method is illustrated, validated, and compared against three different fuzzy MCDM methods (fuzzy VIKOR, fuzzy TOPSIS, and fuzzy ELECTRE) in terms of its ranking performance. Also, the relationships between the compared methods and the proposed scenarios for fuzzy PROMETHEE are evaluated via the Spearman’s correlation coefficient. Styrene Maleic Anhydride and Polypropylene are determined optionally as suitable materials for the automotive instrument panel case. We propose a generic fuzzy MCDM methodology that can be practically implemented to material selection problem. The main advantages of the methodology are consideration of the vagueness, uncertainty, and fuzziness to decision making environment.
       
  • Prevalence of porcine reproductive and respiratory syndrome virus and
           porcine parvovirus antibodies in commercial pigs, southwest Nigeria

    • Abstract: Publication date: March 2018Source: Beni-Suef University Journal of Basic and Applied Sciences, Volume 7, Issue 1Author(s): Comfort O. Aiki-Raji, Adebowale I. Adebiyi, John O. Abiola, Daniel O. Oluwayelu Porcine reproductive and respiratory syndrome virus (PRRSV) and porcine parvovirus (PPV) infections cause significant economic losses to the pig industry and are considered the most economically important viral diseases of intensive swine production. Despite numerous reports on both diseases in several countries worldwide, the status of PRRSV and PPV in Nigeria remains largely unknown. Thus, a serological survey was conducted to determine the prevalence of PRRSV and PPV infections in pigs in Southwest Nigeria. Using commercial ELISA kits, 368 pig sera were screened for antibodies against PRRSV (types I and II) and PPV. Significantly higher antibody prevalence was obtained for PRRSV (53.8%) compared to PPV (36.1%). Since there is no vaccination against both diseases in the country, the findings of this study suggest that PRRSV and PPV are present in the pig population in southwest Nigeria. There should be continuous monitoring of pigs for these diseases in Nigeria since both viruses are associated with major economic losses in the swine industry, affecting all stages of production. This will help to ascertain the actual burden and increase awareness of both diseases to facilitate early detection in order to institute appropriate control measures in the country.
       
  • In silico binding affinity studies of N-9 substituted
           6-(4-(4-propoxyphenyl)piperazin-1-yl)-9H-purine derivatives-Target for
           P70-S6K1 & PI3K-δ kinases

    • Abstract: Publication date: March 2018Source: Beni-Suef University Journal of Basic and Applied Sciences, Volume 7, Issue 1Author(s): Manjunath G. Sunagar, P. Aravind, Supreet Gaonkar, K.S. Devaraju, Shrinivas D. Joshi, Sheshagiri R. Dixit, B.M. Harish, Imtiyaz Ahmed M. Khazi P70-S6K1 & PI3K-δ kinases are identified to be involved in many physiological processes associated with cancer, therefore many of the inhibitors being designed to target these kinases are in clinical trials. In the current study we have exploited the N-9 substituted 6-(4-(4-propoxyphenyl) piperazin-1-yl)-9H-purine derivatives for their inhibitory properties with the above kinases. We have used an in silico docking study with seventeen purine derivatives for their binding affinity calculations. The binding affinities of these small molecules with P70-S6K1 & PI3K-δ were performed using AutoDock Vina. Among all the compounds, PP16 showed highest binding affinity of −14.7 kcal/mol with P70-S6K1 kinase & −17.2 kcal/mol with PI3K-δ kinases as compared to the molecules under clinical trials (PF-4708671 & IC-87114). Docking studies revealed that N-9 coumarine substituted purine derivative could be one of the potential ligands for the inhibition of P70-S6K1 & PI3K-δ kinases. Hence, this compound can be further investigated by in vitro and in vivo experiments for further validation.Graphical abstractGraphical abstract for this article
       
  • Detection of methicillin resistant and toxin-associated genes in
           Staphylococcus aureus

    • Abstract: Publication date: March 2018Source: Beni-Suef University Journal of Basic and Applied Sciences, Volume 7, Issue 1Author(s): Cajethan Ezeamagu, Irene Imanatue, Margaret Dosunmu, Adebola Odeseye, Glory Baysah, Daniel Aina, Foluke Odutayo, Grace Mensah-Agyei Methicillin-resistant Staphylococcus aureus is a problem in both healthcare institutions and community settings. This is due to its multi-drug resistant challenges. Hence, this study assessed the prevalence of methicillin resistant gene (mecA), exfoliative toxin (eta and etb) and toxic shock syndrome (tsst-1) genes in S. aureus isolated from clinical samples. A total of 120 clinical samples of patients (urine, high vagina swab (HVS), semen, wound swab, sputum and urethral swab) from a hospital laboratory were obtained. S. aureus was isolated and then identified with API-staph kit. Antibiotic susceptibility of the isolates was determined by agar diffusion while PCR was used to detect the presence of mecA and toxin-associated genes. Fifty S. aureus isolates were obtained at frequencies of 26(52%), 12(24%), 4(8%), 3(6%), 3(6%) and 2(4%) from the HVS, urine, semen, wound, sputum and urethral swab samples respectively. All the isolates of S. aureus were resistant to the antibiotics used in this study. MecA, tsst-1, eta and etb were detected in 19(38%), 7(14%), 3(6%) and 2(4%) of the isolates respectively. The prevalence of MRSA and its resistance pattern observed in this study was a signal that the health-care workers and the general public are at risk.
       
  • Role of marine macroalgae in plant protection & improvement for
           sustainable agriculture technology

    • Abstract: Publication date: March 2018Source: Beni-Suef University Journal of Basic and Applied Sciences, Volume 7, Issue 1Author(s): Seham M. Hamed, Amal A. Abd El-Rhman, Neveen Abdel-Raouf, Ibraheem B.M. Ibraheem Marine macroalgae are plant-like organisms with simple internal structures that generally live in coastal areas. They mainly include different communities of red, brown and green macroalgae. Marine macroalgae commonly occupy intertidal and sublittoral-to-littoral zones on rocks and other hard substrata. They are considered to be an excellent natural biosource in different aspects of agricultural fields. They have great proficiency in improving soil physical and chemical properties. Marine macroalgae are also characterized by producing a large array of biologically active biocidal substances against plant-infecting pathogens. Unfortunately, most available literatures on marine macroalgae and their derivatives mainly focused on their pharmaceutical applications but their potential utilization in sustainable agriculture development is still often regarded as a secondary goal. However, a relatively considerable dataset on marine macroalgae showed that they could play a major role in plant protection and improvement. This review summarizes different aspects of potential macroalgal applications in agriculture. Commercial production and exploitation of specific compounds with interesting biotechnological importance from marine macroalgae including microbicides, nematicides, insecticides, biofertilizers, biostimulators and soil conditioners are highlighted and discussed in detail. Bioactive compounds like fatty acids (in particular polyunsaturated fatty acids (PUFAs), proteins (amino acids), bioflavonoids, sulfated polysaccharides, carotenoids, polyphenols and carbohydrates are considered to have bactericidal, antiviral and fungicidal effects against some plant-infecting pathogens. These biocontrol agents provide multiple benefits and act as useful pointers for improving cultivation practices in diverse habitats. Marine macroalgae can be generally considered as promising multifunctional bioinoculants and ecofriendly environmental tools in recent trends of organic farming.
       
  • Synergistic effect of ACE and AGT genes in coronary artery disease

    • Abstract: Publication date: March 2018Source: Beni-Suef University Journal of Basic and Applied Sciences, Volume 7, Issue 1Author(s): Ibrahim H. Borai, Nahla S. Hassan, Olfat G. Shaker, Esmat Ashour, Mohammed E.l. Badrawy, Olfat M. Fawzi, Lamiaa Mageed Polymorphisms of the renin-angiotensin system genes influence the pathogenesis of atherosclerosis and are connected with heart diseases. We explore the potential associations of ACE (I/D) and AGT (M235T) gene polymorphisms with coronary artery disease (CAD). A total of one hundred and twenty Egyptian patients (Sixty with CAD and sixty without CAD) and fifty healthy control subjects were included in the study. Genotyping of ACE (I/D) and AGT (M235T) were analyzed by the polymerase chain reaction (PCR) technique. Serum lipid profiles (total cholesterol, triglyceride, HDL-C) were measured by the enzymatic colorimetric method. Our data showed that the ACE D allele frequency (P 
       
  • Design of twisted tape turbulator at different entrance angle for heat
           transfer enhancement in a solar heater

    • Abstract: Publication date: March 2018Source: Beni-Suef University Journal of Basic and Applied Sciences, Volume 7, Issue 1Author(s): Suvanjan Bhattacharyya, Himadri Chattopadhyay, Ayan Haldar Numerical investigation of heat transfer characteristics in a tube fitted with inserted twisted tape swirl generator is performed. The twisted tapes are separately inserted from the tube wall. The configuration parameters include the, entrance angle (α) and pitch (H). Investigations have been done in the range of α = 180°, 160° and 140° with Reynolds number varying between 100 and 20,000. In this paper, transition – SST model which can predict the transition of flow regime from laminar through intermittent to turbulent has been utilized for numerical simulations. The computational results are in good agreement with experimental data. The results show that higher entrance angle yields a higher heat transfer value. The using of single twist twisted tape supplies considerable increase on heat transfer and pressure drop when compared with the conventional twisted tapes. A large data set has been generated for heat transfer and thermal-hydraulic performance which is useful for the design of solar thermal heaters and heat exchangers.
       
  • Amelioration of anaphylaxis, mast cell degranulation and bronchospasm by
           Euphorbia hirta L. extracts in experimental animals

    • Abstract: Publication date: March 2018Source: Beni-Suef University Journal of Basic and Applied Sciences, Volume 7, Issue 1Author(s): Ghanshyam Parmar, Kilambi Pundarikakshudu, R. Balaraman, Girish Sailor The current investigation was aimed to assess anti-anaphylactic, mast cell stabilizing and anti-asthmatic activity of methanol and aqueous extract of Euphorbia hirta L. (Euphorbiaceae) on experimental animals. Anaphylaxis was induced by administration of horse serum and triple antigen vaccine subcutaneously in albino Wistar rats. Extracts of E. hirta (EH) were administered to the rats in dose of 250 and 500 mg/kg b.w. orally for 14 days. At the end of treatment, asthma score was measured and various blood parameters like differential count (DC), total WBC count and IgE were estimated. Interleukin (IL)-4, IL-5 and tumour necrosis factor (TNF)-α were measured by ELISA commercial kit from Broncho alveolar lavage fluid (BALF). Histopathological changes of lungs were observed. Anti-asthmatic activity of extracts of EH was also studied on histamine-induced bronchospasm in guinea pigs. In vitro mast cell stabilizing activity of extracts was evaluated on compound 48/80 challenged rat intestinal mesenteric mast cells. The treatment with extracts of EH produced significant decrease in asthma score and they also brought to normalcy the increased total WBC, DC counts, serum IgE, TNF-α, IL-4 and IL-5 in BALF. The histopathological study further supported the protective effect of EH extracts. The pre-treatment with extracts of EH displayed significant reduction in degranulation of mesenteric mast cell numbers. The treatment with extracts of EH significantly increased in time of pre-convulsive dyspnoea (PCD). Thus, these findings concluded that E. hirta could be effectively used in the treatment of anaphylaxis and asthma.
       
  • Adulticidal and repellent activities of some botanical oils against
           malaria mosquito: Anopheles gambiae (Diptera: Culicidae)

    • Abstract: Publication date: March 2018Source: Beni-Suef University Journal of Basic and Applied Sciences, Volume 7, Issue 1Author(s): Olajide J. Afolabi, Iyabo A. Simon-Oke, Oluwadoyinsolami O. Elufisan, Mobolanle O. Oniya The study is undertaken to determine the adulticidal efficacy and repellent activity of different solvent extracts of Ocimum caninum, Ocimum gratissimum, Chromolaena odorata and Datura stramonium against adult Anopheles gambiae. The extracts showed adulticidal activity at LC50 (0.82–4.58 mg/l) and LC90 (2.38–8.33 mg/l). The highest mortality was observed in Ocimum gratissimum and Datura stramonium with the LC50 and LC90 values of 2.35 mg/l, 4.75 ml/l and 0.82 mg/l, 2.38 mg/l respectively. Meanwhile, the lowest adulticidal activity was recorded in Chromolaena odorata with the lowest LC50 (4.52 mg/l) and LC90 (8.32 mg/l). The repellent efficacy was determined against the mosquitoes at five concentrations viz 1.0, 2.0, 3.0, 4.0 and 5.0 mg/l under laboratory condition (28 ± 2 °C, 75 ± 5% RH, 12L: 12D photoperiod). The results showed complete protections of 90 min for Ocimum caninum, 120 min for Ocimum gratissimum, 30 min for Chromolaena odorata and 120 min for Datura stramonium at 5 mg/l of the extracts respectively. It was observed that D. stramonium and O. gratissimum provided highest protection (120 min) against Anopheles gambiae while the least protection (30 s) was observed in Chromolaena odorata at 5 mg/l. The results of the study showed that all the crude extracts with the exception of Chromolaena odorata were potential botanicals for confirming protection on the exposed parts of human body against Anopheles gambiae for at least 90 min and as such can be included in integrated vector management to reduce malaria infection in endemic areas.
       
  • Interactive Approach for Multi-Level Multi-Objective Fractional
           Programming Problems with Fuzzy Parameters

    • Abstract: Publication date: March 2018Source: Beni-Suef University Journal of Basic and Applied Sciences, Volume 7, Issue 1Author(s): M.S. Osman, O.E. Emam, M.A. Elsayed In this paper, an interactive approach for solving multi-level multi-objective fractional programming (ML-MOFP) problems with fuzzy parameters is presented. The proposed interactive approach makes an extended work of Shi and Xia (1997). In the first phase, the numerical crisp model of the ML-MOFP problem has been developed at a confidence level without changing the fuzzy gist of the problem. Then, the linear model for the ML-MOFP problem is formulated. In the second phase, the interactive approach simplifies the linear multi-level multi-objective model by converting it into separate multi-objective programming problems. Also, each separate multi-objective programming problem of the linear model is solved by the ∊-constraint method and the concept of satisfactoriness. Finally, illustrative examples and comparisons with the previous approaches are utilized to evince the feasibility of the proposed approach.
       
  • Rapid biosynthesis of silver nanoparticles using the marine red alga
           Laurencia catarinensis and their characterization

    • Abstract: Publication date: March 2018Source: Beni-Suef University Journal of Basic and Applied Sciences, Volume 7, Issue 1Author(s): Neveen Abdel-Raouf, Reem Mohammed Alharbi, Nouf Mohammed Al-Enazi, Manal Mohammed Alkhulaifi, Ibraheem Borie Mohammad Ibraheem Bio-synthesis of AgNPs (silver nanoparticles) by using of the dry and solvent extract of red marine alga Laurencia catarinensis was conducted in the present work. Characterizations of the formed AgNPs was approved by UV–Visible Spectroscopy, Transmission Electron Microscopy, Dynamic Light Scattering and finally by Fourier Transform Infrared spectroscopy. We achieved the synthesis of AgNPs by the reduction of aqueous solutions of AgNO3 with the powder and extract of Laurencia catarinensis. Bio-synthesis of Ag nanoparticles was confirmed by visual inspection. The obtained algal nanoparticles were characterized by highly stable formation, short time of the biogenic process (2 min-3 h), small size (39.41–77.71 nm) with several shapes (spherical, triangular, rectangle, polyhedral and hexagonal).
       
  • Antibacterial and anti-hyperlipidemic activities of the green alga
           Cladophora koeiei

    • Abstract: Publication date: March 2018Source: Beni-Suef University Journal of Basic and Applied Sciences, Volume 7, Issue 1Author(s): Neveen Abdel-Raouf, Nouf Mohammed Al-Enazi, Ibraheem Borie Mohammad Ibraheem, Reem Mohammed Alharbi, Manal Mohammed Alkhulaifi In the present investigation, an antihyperlipidemic activity of Cladophora koeiei ethanol extract against six pathogenic bacteria was conducted. Also, we evaluate the activity of the alga extract against hyperlipedemia in the administrated albino rates through measuring the blood lipid profiles [triglycerides (TG), total cholesterol (TC), low-density lipoprotein (LDL-C), high-density lipoprotein cholesterol (HDL-C), cholesterol] and induced hepatic damage by measuring the contents of creatinine, total proteins, blood urea nitrogen (BUN), albumin and globulin and diagnostic marker enzymes such as aspartate aminotransaminase (AST) and alanine aminotransaminase (ALT). Alga extract proved efficient activity against the tested bacteria ranged between medium and high suppression action. Results revealed also, the efficiency of C. koeiei extract in the decreasing the triglycerides (TG), total cholesterol (TC), low-density lipoproteins (LDL-C), blood urea nitrogen (BUN) and creatinine caused by alcohol. However, the treatment by alga extract exhibits high-density of lipoproteins (HDL-C) (beneficial), total protein, albumin, and globulins. Also, the algal treatments masking the lethal effects caused by harmful alcohol from raising the rate of enzymes ALT, AST, which returned to the normal state in the groups treated with alga extract. Our findings provide the evidence that new natural antioxidant substances can be present in the C. koeiei extract and hence this alga proves to be effective as a source for therapeutic agents.
       
  • The heat transfer enhancement techniques and their Thermal Performance
           Factor

    • Abstract: Publication date: March 2018Source: Beni-Suef University Journal of Basic and Applied Sciences, Volume 7, Issue 1Author(s): Chirag Maradiya, Jeetendra Vadher, Ramesh Agarwal Heat transfer devices have been used for conversion and recovery of heat in many industrial and domestic applications. Over five decades, there has been concerted effort to develop design of heat exchanger that can result in reduction in energy requirement as well as material and other cost saving. Heat transfer enhancement techniques generally reduce the thermal resistance either by increasing the effective heat transfer surface area or by generating turbulence. Sometimes these changes are accompanied by an increase in the required pumping power which results in higher cost. The effectiveness of a heat transfer enhancement technique is evaluated by the Thermal Performance Factor which is a ratio of the change in the heat transfer rate to change in friction factor. Various types of inserts are used in many heat transfer enhancement devices. Geometrical parameters of the insert namely the width, length, twist ratio, twist direction, etc. affect the heat transfer. For example counter double twisted tape insert has TPF of more than 2 and combined twisted tape insert with wire coil can give a better performance in both laminar and turbulent flow compared to twisted tape and wire coil alone. In many cases, roughness gives better performance than the twisted tape as seen in case of flow with large Prandtl Number. The artificial roughness can be developed by employing a corrugated surface which improves the heat transfer characteristics by breaking and destabilizing the thermal boundary layer. This paper provides a comprehensive review of passive heat transfer devices and their relative merits for wide variety of industrial applications.
       
  • Evaluation of the epidural analgesic effect of Nalbuphine, Lidocaine and
           Nalbuphine-Lidocaine combination in bucks

    • Abstract: Publication date: March 2018Source: Beni-Suef University Journal of Basic and Applied Sciences, Volume 7, Issue 1Author(s): G.A. Ragab, M.Z. Fathy Nalbuphine is a lipophilic opioid which could be used subcutaneously, intramuscularly, intravenously and epidurally in human, dogs and equine but not used in bucks until yet. The aim of the existing study was to compare the analgesic effect of Nalbuphine, Lidocaine and Nalbuphine-Lidocaine combination injected epidurally in bucks. Fifteen adult apparently healthy bucks were used. The animals were randomly divided into three groups (five animals in each one); group (1) was injected with Nalbuphine HCl at a dose 3 mg/kg, group (2) was injected with Lidocaine HCl 2% at a dose 2.5 mg/kg. Finally, group (3) was injected with Nalbuphine-Lidocaine combination at a dose (1.5 mg/kg and 1.25 mg kg, resp.) to evaluate the analgesic effect of each treatment. Onset and duration of analgesia were recorded after each treatment. Respiratory rate, heart rate, rectal temperature and biochemical parameters were recorded for each treatment. The results revealed that, the onset and duration of analgesia respectively were 12 ± 2 min and 200 ± 4 min in group (1), 6 ± 1 min and 80 ± 3 min in group (2) and 8 ± 2 min and 120 ± 5 min in group (3). In Nalbuphine group, No ataxia was observed while mild ataxia was observed in Nalbuphine-Lidocaine combination group but in Lidocaine treated group, sever ataxia was recorded. Heart rate increased at 90–120 and respiratory rate rectal temperature had no any significantly differentiation from baseline of any treatment. Biochemical parameters returned to basal levels through three hours after all treatments. In conclusion, Nalbuphine-Lidocaine combination is useful to perform surgical operations of long duration and had effective analgesia in bucks.
       
  • Synthesis, spectroscopy characterization and biological activities of some
           novel 1-(3-(N,N-dimethylamino)-1-(5-substituted thiophene-2-yl)
           propylidene semicarbazone Mannich base derivatives

    • Abstract: Publication date: Available online 22 February 2018Source: Beni-Suef University Journal of Basic and Applied SciencesAuthor(s): Chandravadivelu Gopi, Magharla Dasaratha Dhanaraju The main aim of this work was to synthesise a novel 1-(3-(N,N-dimethylamino)-1-(5-substituted thiophene-2-yl)propylidene semicarbazone Mannich base derivatives and examine the anti-diabetic and anti-inflammatory activities using alloxan-induced diabetic and carrageenan-induced paw oedema methods. These analogues were prepared by performing a condensation reaction between 1-(thiophen 2-yl) ethanone, formaldehyde, N,N-dimethyl amine hydrochloride and semicarbazide. The prepared analogues were characterised by FT-IR, 1H NMR, 13C NMR, mass spectroscopy and elemental analysis. The result reveals that most of the compounds were significantly reduced in the blood glucose level and inflammation of paw volume of experimental animals as compared to the standard drugs.
       
  • Di-(2-ethylhexyl) Phthalate, a major bioactive metabolite with
           antimicrobial and cytotoxic activity isolated from River Nile derived
           fungus Aspergillus awamori

    • Abstract: Publication date: Available online 6 February 2018Source: Beni-Suef University Journal of Basic and Applied SciencesAuthor(s): Momen M. Lotfy, Hossam M. Hassan, Mona H. Hetta, Ahmed O. El-Gendy, Rabab Mohammed The main objective of this study is to investigate the still unexplored River Nile habitat since it was found little information on the chemistry and biology of the River Nile derived microorganisms. Therefor it was claimed to isolate a number of microorganisms, identify them and test their antimicrobial activities. On the other hand isolation of at least one bioactive metabolite from isolated fungus grown under static condition. A number of microorganisms has been isolated using three different media; TSA (Trypton Soya Agar), SDA (Sabroud Dextrose Agar) and ISP4 (International Streptomyces Project 4), their antimicrobial activities were studied using two agar diffusion methods; cup and modified agar disc methods. Chromatographic techniques were used for isolation of one compound which also tested for its antimicrobial and cytotoxic activity. Thirty-four versatile isolates were recovered, related to Gram positive bacteria, Gram negative bacteria, fungi and actinomycetes. The antimicrobial screening showed varying activities against tested strains in both methods. Isolation of Di-(2-ethylhexyl) Phthalate (DEHP) compound from fungus Aspergillus awamori had been succeeded, it is the first report for its isolation from the titled fungus, DEHP exhibited activity against Candida albicans fungus and the Gram positive bacteria Sarcina lutea, also DEHP showed cytotoxic activity against some carcinoma cell lines. It can be concluded that the River Nile could be a tremendous resource for production of bioactive metabolites.
       
  • Wheat germ and vitamin E decrease BAX/BCL-2 ratio in rat kidney treated
           with gentamicin

    • Abstract: Publication date: Available online 5 February 2018Source: Beni-Suef University Journal of Basic and Applied SciencesAuthor(s): Mohamed A.M. Kandeil, Kamel M.A. Hassanin, Eman T. Mohammed, Ghada M. Safwat, Doaa Sh. Mohamed The intracellular accumulation of gentamicin acts on mitochondria directly (by increasing oxidative stress) and indirectly (by increasing the proapoptotic BAX gene expression levels) and thus activates intrinsic pathway of apoptosis. This study intended to investigate the probable prophylactic effect of wheat germ as a nephro-protective agent in relation to vitamin E as a well-known natural antioxidant on a nephrotoxic model induced by gentamicin. Forty male Sprague Dawley rats were divided randomly into four groups; of 10 rats each: control group, gentamicin group (120 mg/kg/day i.p. for 15 days), vitamin E group (200 mg/kg orally for 45 days) and wheat germ group (20% of the diet for 45 days). Gentamicin injection was started on the 30th day for both groups (3) and (4). It was noticed that wheat germ significantly decreased BAX/BCL-2 ratio. The significant decrement in MDA level and the significant increment in total antioxidant capacity (TAC) level and catalase (CAT) activity of wheat germ treated rats reflecting its antioxidant activity. Additionally, the wheat germ succeeded in improvement of the kidney function of rats of this group which was manifested by amelioration of deteriorated serum creatinine, urea, sodium and potassium levels. In conclusion, the efficacy of wheat germ as anti-apoptotic and antioxidant was higher than that of vitamin E and it effectively protected against the direct and indirect toxic effects of gentamicin on kidney through regulation of BAX-BCL-2 gene expressions and further inhibition of mitochondrial cytochrome c translocation into cytosol.
       
  • Biochemical and Apoptotic Biomarkers of Experimentally Induced Traumatic
           Brain Injury: In Relation to Time since Death

    • Abstract: Publication date: Available online 31 January 2018Source: Beni-Suef University Journal of Basic and Applied SciencesAuthor(s): Amany Abdel-Rahman Mohamed, Khlood M. Elbohi, Nabela I. El Sharkawy, Mona A. Hassan The present study declares the relationship between the cause of death and postmortem biochemical marker alterations in CSF, serum and plasma. In addition, immunohistochemical and microarchitecture examination of brain tissue of White New Zealand rabbits at different PMI after traumatized death. Thirty adult male White New Zealand rabbits were divided into two main equal groups; the first was physically killed by cervical dislocation and the second through head trauma. Each group was subdivided into three PMIs (zero, 6, and 12hrs PM). CSF was used to detect the levels of K+, Na+, Ca++, albumin While, lactic acid, hypoxanthine, ammonia and uric acid concentrations were measured in plasma. Estimation of HMGB1, IL-1β and TNF-α were assessed in serum. In addition to immunohistochemical observations of Bcl-2 and P53 apoptotic proteins in brain tissue. The results revealed that some of the examined parameters as K+, Na+, albumin, ammonia, hypoxanthine and HMGB1 had the potential role in estimation of PMI at examined time periods in physical and traumatized death. Traumatic death induced severe cerebral hemorrhages and necrosis of cerebral parenchyma than physical death. Immunohistochemical results of P53 and Bcl-2 in brain tissue declared focal positive reactions of some neurons, astrocytes and microglia in different degrees with time since death. It was concluded that biochemical analysis of some body fluids, tissue pathological changes and apoptotic markers are applicable tools for assessing accurate PMI after traumatic brain injury and could have a crucial role in legal medicine
       
 
 
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