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Showing 1401 - 1205 of 1205 Journals sorted alphabetically
Transportation Research Record : Journal of the Transportation Research Board     Full-text available via subscription   (Followers: 32)
Transportmetrica A : Transport Science     Hybrid Journal   (Followers: 8)
Trends in Applied Sciences Research     Open Access   (Followers: 1)
Tribology in Industry     Open Access   (Followers: 4)
Tribology International     Hybrid Journal   (Followers: 46)
Tribology Letters     Hybrid Journal   (Followers: 7)
Tribology Transactions     Hybrid Journal   (Followers: 35)
Trilogía     Open Access  
Turkish Journal of Engineering     Open Access  
Turkish Journal of Engineering and Environmental Sciences     Open Access   (Followers: 1)
Türkiye Arazi Yönetimi Dergisi     Open Access  
Türkiye Coğrafi Bilgi Sistemleri Dergisi     Open Access  
Türkiye Fotogrametri Dergisi     Open Access  
Türkiye İnsansız Hava Araçları Dergisi     Open Access  
U.Porto Journal of Engineering     Open Access  
UKH Journal of Science and Engineering     Open Access  
Ultramicroscopy     Hybrid Journal   (Followers: 4)
Uludağ University Journal of The Faculty of Engineering     Open Access  
Uluslararası Mühendislik ve Teknoloji Araştırmaları Dergisi / International Journal of Engineering and Technology Research     Open Access  
Universal Journal of Applied Science     Open Access   (Followers: 2)
Universal Journal of Engineering Science     Open Access   (Followers: 2)
Universidad, Ciencia y Tecnología     Open Access   (Followers: 1)
Usak University Journal of Engineering Sciences     Open Access  
Utilities Policy     Hybrid Journal   (Followers: 2)
Vacuum     Hybrid Journal   (Followers: 12)
Vestnik of Don State Technical University     Open Access  
Vibration     Open Access   (Followers: 16)
Virtual and Physical Prototyping     Hybrid Journal   (Followers: 4)
Visualization in Engineering     Open Access   (Followers: 1)
Walailak Journal of Science and Technology     Open Access  
Waste and Biomass Valorization     Hybrid Journal   (Followers: 3)
Waste Management Series     Full-text available via subscription   (Followers: 1)
Waves in Random and Complex Media     Hybrid Journal  
Waves, Wavelets and Fractals - Advanced Analysis     Open Access  
Wear     Hybrid Journal   (Followers: 27)
Welding in the World     Hybrid Journal   (Followers: 7)
West African Journal of Industrial and Academic Research     Open Access   (Followers: 2)
World Electric Vehicle Journal     Open Access  
World Journal of Engineering and Technology     Open Access  
World Journal of Environmental Engineering     Open Access   (Followers: 3)
World Pumps     Full-text available via subscription   (Followers: 2)
World Science and Technology     Full-text available via subscription  
Yugra State University Bulletin     Open Access   (Followers: 1)
ZDM     Hybrid Journal   (Followers: 1)
Zede Journal     Open Access   (Followers: 1)
Zeitschrift für Arbeitswissenschaft     Hybrid Journal  
Zeitschrift fur Energiewirtschaft     Hybrid Journal  
Вісник Приазовського Державного Технічного Університету. Серія: Технічні науки     Open Access  

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World Science and Technology
Number of Followers: 0  
 
  Full-text available via subscription Subscription journal
ISSN (Print) 1876-3553
Published by Elsevier Homepage  [3207 journals]
  • CDISC Standards and Clinical Research Data Standardization of Traditional
           Chinese Medicine
    • Abstract: Publication date: December 2012
      Source:World Science and Technology , Volume 14, Issue 6
      Author(s): Yanlan Li , Jingqing Hu , Baoyan Liu
      More and more attention has been paid to the standardization of clinical research data. International clinical data standards mainly include four categories, which are the File Format, Exchange Standard, Analysis Standard and Terminology Standard. Clinical Data Interchange Standards Consortium (CDISC) is the main criteria of exchanging standard and analyzing standard currently. Backwardness of quality and level of the data management have become one of the most important factors that affect the sustained, rapid and healthy development of domestic clinical trials. How to apply international standards of clinical data to narrow the gap of clinical research of Chinese medicine with the international advanced level is a topic which needs to be continuously explored. This paper firstly introduced the CDISC and its two standards, then analyzed the significance of data standardization in clinical research of traditional Chinese medicine (TCM), and finally discussed problems existed in the process of TCM clinical research using CDISC standards. It was suggested that the strengthening on research of relevant TCM semantic structure and its terminology standard is the key problem. The only way to solve this problem is to use the CDISC standards.

      PubDate: 2013-06-01T09:30:50Z
       
  • Study on Application of Medical Diagnosis by Electronic Nose
    • Abstract: Publication date: December 2012
      Source:World Science and Technology , Volume 14, Issue 6
      Author(s): Zhezhou Zheng , Xuejuan Lin
      In recent years, with the in-depth research of electronic nose technology, the bionic olfactory system has been widely applied in the medical field. This article elaborated basic components, working principle, recent achievements of electronic nose in the modern medical application. And it proposed a new mode about combination of the electronic nose technology with the dialectical thinking of traditional Chinese medicine (TCM).

      PubDate: 2013-06-01T09:30:50Z
       
  • Electronic Nose and Its Application in Chinese Materia Medica
    • Abstract: Publication date: December 2012
      Source:World Science and Technology , Volume 14, Issue 6
      Author(s): Huiqin Zou , Yu Han , Shu Xing , Queyue Lin , Zedong Wei , Yin Xiong , Yonghong Yan
      Electronic nose (E-nose) is a rapid, simple, sensitive and accurate technology for the quality evaluation of Chinese materia medica (CMM). In this paper, several CMM samples of different species, habitats, storage time, and so on were analyzed by E-nose. Based on experimental data, specific discrimination model was established according to specific research target using different pattern recognition algorithms including PCA, DFA, PLS, BP-ANN and so on. It showed that the models were reliable and stable. It was concluded that E-nose can be applied to effectively extract and analyze the odor traits of CMM. It is a unique and useful tool for research on the identification, quality control and validity evaluation of CMM.

      PubDate: 2013-06-01T09:30:50Z
       
  • Advances in Ginsenoside Rh2 and Its Derivatives
    • Abstract: Publication date: December 2012
      Source:World Science and Technology , Volume 14, Issue 6
      Author(s): Man Cao , Jie Zhang , Yang Zhao , Xinbo Song , Baiping Ma
      Ginsenoside Rh2, one of the characteristic components in red ginseng (roots steamed at 98-100 °C without peeling), is a rare ginsenoside with potential bioactivity. The preparation of ginsenoside Rh2 was studied by using acid hydrolysis, alkaline hydrolysis, synthesis and biotransformation techniques. Microbial and enzymatic transformations were regarded as the optimization methods of all these techniques, owing to their high specificity, yield and productivity. The pharmacological activities and pharmacokinetics of ginsenoside Rh2 and its derivatives were extensively researched. In this paper, their preparation and activities have been reviewed, which can provide information for the research and development of ginsenoside Rh2.

      PubDate: 2013-06-01T09:30:50Z
       
  • Latest Advancement for Detection Methods of Mycotoxins in Traditional
           Chinese Medicine
    • Abstract: Publication date: October 2012
      Source:World Science and Technology , Volume 14, Issue 5
      Author(s): Feng Xu , Kong Weijun , Yang Meihua , Ouyang Zhen
      Mycotoxins are secondary metabolites produced by certain fungi, which can trigger cancers, deformity and mutation, and are greatly harmful to cells, kidney, reproductive system and immune system. During harvesting, processing, transportation and storage of the plants, Chinese materia medica (CMM) can be easily contaminated by mycotoxins. Not only can it influence the quality and efficacy of CMM, but also do great harm to human body. Therefore, it seems important and necessary to establish sensitive and accurate methods to detect the mycotoxins in CMM. This paper reviewed the advancement of detection methods for mycotoxins in CMM to provide some references for related studies.

      PubDate: 2013-06-01T09:30:50Z
       
  • Analysis of Anti-cancer Traditional Chinese Medicine Injections based on
           Market Performance
    • Abstract: Publication date: October 2012
      Source:World Science and Technology , Volume 14, Issue 5
      Author(s): Yunfeng Lai , Jinjian Lu , Xiuping Chen , Hao Hu , Yitao Wang
      Traditional Chinese medicine injections (TCMIs) have played vital roles in the treatment of cancer, cardiovascular diseases, virus and so on. This article analyzed the market of anti-cancer TCMIs in China, with special emphasis on Kang'ai Injection, Shenqi Fuzheng Injection, Aidi Injection, Lentinan Injection and Compound Kushen Injection, which presented excellent market performances. An analysis on the technical features and clinical applications of these five anti-cancer TCMIs was also conducted. Finally, we pointed out constraints and possible solutions to the development of anti-cancer TCMIs.

      PubDate: 2013-06-01T09:30:50Z
       
  • Research on No-Reflow Phenomenon after PCI and the Open and Close of
           Xuanfu
    • Abstract: Publication date: October 2012
      Source:World Science and Technology , Volume 14, Issue 5
      Author(s): Shichao Lv , Junping Zhang
      No-Reflow (NR) is the common complication after percutaneous coronary intervention (PCI). It has a complex pathogenesis. Modern medicine has no ideal prevention and treatment method. Through systematic literature review, in the Xuanfu (mysterious mansion) theory, NR is due to the reason that Qi and blood cannot moisten and nourish myocardium. The key is dysfunction of Xuanfu. Xuanfu is both the gate of Qi ascending, descending, exiting and entering movement and the channel of body fluid circulation. The basic pathogenesis of NR is the blockage of Xuanfu. We propose that the method of dredging Xuanfu can be used in the treatment of NR. It is a new thought for the prevention and treatment of NR. It has a significant meaning for increasing the treatment effect of PCI.

      PubDate: 2013-06-01T09:30:50Z
       
  • Experience of Professor Shen Shu-wen in the Treatment of Migraine
    • Abstract: Publication date: October 2012
      Source:World Science and Technology , Volume 14, Issue 5
      Author(s): Zhihong Yang , Shuwen Shen , Yahuan Yuwen
      Professor Shen Shu-wen is the national traditional Chinese medicine (TCM) academic expert of the fourth and the fifth batch of the experience inheritance of famous and veteran doctors of TCM in China. He is specialized in the treatment of rare illness of internal medicine. He emphasizes on the clinical efficacy in the process of innovation. This paper introduced his clinical experiences on the treatment of migraine briefly.

      PubDate: 2013-06-01T09:30:50Z
       
  • Thought and Practice of Study of Tumor Treatments by Traditional Chinese
           Medicine Based on Collection and Analysis Platform of Known TCM Veteran
           Physicians
    • Abstract: Publication date: August 2012
      Source:World Science and Technology , Volume 14, Issue 4
      Author(s): Zhang Runshun , Zhou Xuezhong , Wang Yinghui , Liu Baoyan , Zheng Honggang , Wu Jie , Li Daorui
      This paper describes the use of information collection and the analysis and mining platform of famous traditional Chinese medicine (TCM) doctors in carrying out the study of syndromes, characteristics, and treatment methods of tumors in different periods, core herbal formulas, drug addition, subtraction and other research. It is conducive to summarize the tumor syndrome differentiations and treatments systematically, and to promote the heritage of the experience of known veteran TCM doctors.

      PubDate: 2013-04-18T08:02:34Z
       
  • Optimization Mode of Innovative Chinese Medicine Formulations Based on
           Traditional Chinese Medicine Hospital Preparations
    • Abstract: Publication date: August 2012
      Source:World Science and Technology , Volume 14, Issue 4
      Author(s): Tian Yuanxiang , Lei Yan , Cao Hongxin , Weng Weiliang
      This study was aimed at investigating the optimization model of innovative Chinese medicine formulations based on traditional Chinese medicine (TCM) hospital preparations. A literature review was conducted to analyze the importance and characteristics of TCM hospital preparations. Then, the optimization process and methods of hospital preparations were summarized and explored. The results showed that hospital preparation is an important and fundamental resource of new drug development, with characteristics of abundant clinical experience, multiple formulations, multiple dosage forms, well-established efficacy and reliable safety. Hospital preparations may provide a rich material foundation for the screening of new drug development, which can shorten the development cycle and reduce research cost. However, there is still a gap between hospital preparations and innovative drugs. Based on our optimization work experiences, the optimization of hospital preparations should comply with the general principles and process of optimizing innovative Chinese medicine formulations, which can be divided into three parts, i.e., optimization of component formulation, optimization of clinical trial protocols and assessment before and after clinical trials. The optimization process should be well focused, so as to facilitate comprehensive optimization. Before optimization, the investigational prescription should undergo qualitative and quantitative evaluation for the first time. Based on the sponsor's final revision, the second qualitative and quantitative evaluation should be performed before the initiation of clinical trials. After clinical trials, the prescription should undergo qualitative and quantitative evaluation for the third time according to the findings of clinical trials. It was concluded that it is possible to provide an optimization model of innovative Chinese medicine formulations based on TCM hospital preparations.

      PubDate: 2013-04-18T08:02:34Z
       
  • Behavioral Observation and Analysis of PMS Liver-qi Depression Rat Model
           Established by Chronic Restraint Stress and Resident-Intruder Paradigm
    • Abstract: Publication date: August 2012
      Source:World Science and Technology , Volume 14, Issue 4
      Author(s): Wei Sheng , Wang Haiping , Qiao Mingqi
      This study was aimed at investigating the feasibility of establishing premenstrual syndrome (PMS) liver-qi depression rat model with resident-intruder paradigm compared to chronic restraint stress. The PMS liver-qi depression rat model was prepared with chronic restraint stress and resident-intruder paradigm. The effect was systematically evaluated through behavioral methods such as open-field test and tail suspension test. Then, results from both groups were compared. The results showed that both chronic restraint stress and resident-intruder paradigm can effectively simulate the state of premenstrual depression and postmenstrual disappearance. The results of the open-field test suggested that there was no significant difference between these two methods (P > 0.05). It was concluded that as a social psychological stress method the resident-intruder paradigm can preferably simulate the process of clinical PMS liver-qi depression caused by emotional abnormality and overcome the disadvantage of obvious body stress of the chronic restraint stress method. But the success ratio was too low, and further inspection was needed to examine its stability.

      PubDate: 2013-04-18T08:02:34Z
       
  • Influence of Three Kinds of Traditional Chinese Therapies on Airway
           Remodeling in Asthmatic Rats
    • Abstract: Publication date: August 2012
      Source:World Science and Technology , Volume 14, Issue 4
      Author(s): Xu Zhaoxia , Li Xueliang , Qian Peng , Li Na , Wang Yiqin , Yan Haixia , Guo Rui , Hao Yiming
      This paper was aimed at observing the protective effects of traditional Chinese medicine (TCM) varying in therapeutic methods on airway remodeling in bronchial asthma. Three TCM decoctions, representing body resistance-strengthening therapy, lung-diffusing therapy, and combination therapy, were prepared and administrated peroral to asthmatic rats induced by ovalbumin. Eosinophils (EOS) were counted in bronchoalveolar lavage fluid (BALF), and levels of matrix metalloproteinase (MMP-9) and tissue inhibitors of metalloproteinase (TIMP)-1 were detected in serum by ELISA. The results showed that compared with the control group administration of TCM recipes is significantly effective in reducing EOS infiltration into BALF; there was a drop in MMP-1 level and a rise in TIMP-1 level. It was concluded that the three TCM therapies exerted similar protective effects against bronchial asthma. The improvement in airway remodeling can be attributed in part to the inhibiting infiltration of EOS, down-regulating MMP-9 expression and up-regulating TIMP-1 expression.

      PubDate: 2013-04-18T08:02:34Z
       
  • Exploration of Action Patterns and Mechanisms of Traditional Chinese
           Medicine Incompatibility of Qi–Qing Antagonism and Mutual
           Inhibition/Restraint based on Drug Interaction
    • Abstract: Publication date: June 2012
      Source:World Science and Technology , Volume 14, Issue 3
      Author(s): Duan Jin'ao , Su Shulan , Fan Xinsheng , Qian Dawei , Tang Yuping , Shang Erxin , Guo Jianming , Liu Pei
      This paper proposes three kinds of action patterns of traditional Chinese medicine (TCM) incompatibility based on the theories of Seven Ways of Compatibility and Drug Interaction. These are toxification and potential toxicity action pattern embodied in the characteristic of antagonism, efficiency reduction, and decrease in effect—patterns reflected by the characteristics of mutual inhibition/restraint and toxic-effect multiple action patterns embodying the complex characteristics of antagonism and mutual inhibition/restraint. In addition, we put forward eight possible mechanisms of TCM incompatibility. They are potential toxicity by promoting the release of toxic substances, potential toxicity by producing new toxic components, potential toxicity because of increased toxic components resulting from mutual transformation of chemical constituents, efficiency reduction through inhibiting the dissolving of active components, efficiency reduction through inactivating the active components, toxification that results from toxic metabolites generated in vivo based on drug interaction, adverse effects caused by affecting the physiological disposition of incompatibility combinations, and adverse effects caused by regulating and controlling the drug metabolic enzymes. Furthermore, the authors discussed the correlations between the different action patterns and mechanisms and relationships of the seven ways of compatibility. These opinions would provide references for understanding and researching the essences of TCM incompatibility.

      PubDate: 2013-04-18T08:02:34Z
       
  • Further Study of Indicated Pharmacokinetics of Traditional Chinese
           Medicine
    • Abstract: Publication date: June 2012
      Source:World Science and Technology , Volume 14, Issue 3
      Author(s): Liu Jianxun , Lin Li , Zhang Ying , Li Xinzhi , Lin Chengren , Fu Jianhua
      The efficacious material basis of Chinese formulations is one of the key scientific study aspects in the modernization of Chinese Material Media (CMM). On the basis of the previous work, this paper raises a new concept of “indicated pharmacokinetics of traditional Chinese medicine (TCM)” and analyzes its scientific connotation, research thoughts and data processing method. This study supplies a new method for Pharmacokinetic/Pharmacodynamic (PK-PD) research of TCM. This study explains the efficacious material basis and the compatibility law of Chinese formulations.

      PubDate: 2013-04-18T08:02:34Z
       
  • Decade Research Progress and Development Trend of Complex Prescription
           Compatibility of Traditional Chinese Medicine
    • Abstract: Publication date: June 2012
      Source:World Science and Technology , Volume 14, Issue 3
      Author(s): Ge Yingli , Lu Yanliu , Yang Ming , Song Haiyan , Liu Ping , Ji Guang
      Complex prescription is the primary therapeutic method of traditional Chinese medicine (TCM). It is a key influencing factor in prescription compatibility. During the past decade, researchers have carried out explorations on the compound compatibility law through aspects of pharmacodynamics (PD), pharmacokinetics (PK) and the combination of PD and PK (PD-PK) and achieved significant success. However, a TCM prescription contains various components. The functions of components and the complex interactions among the different components and their metabolic changes in the body have not been well understood. By far, reasonable and standard methods are still lacking in the study of component compatibility of TCM complex prescription. Based on a summary of recent studies of complex prescription, we put forward the new research method of complex prescription compatibility through multi-index comprehensive evaluation for PD-PK indexes of the efficacious components compatibility law.

      PubDate: 2013-04-18T08:02:34Z
       
  • Effect of Glytan on Liver Fibrosis in Portal Hypertensive Rats
    • Abstract: Publication date: June 2012
      Source:World Science and Technology , Volume 14, Issue 3
      Author(s): Du Qinghong , Han Lin , Jiang Junjie , Li Pengtao , Wang Xinyue , Jia Xu
      The aim of this research was to observe the effect of Glytan on rat liver fibrosis and to investigate the mechanism of portal hypertension (PHT). SD male rats with weight between 240 g and 260 g were randomly divided into a sham group, model group, propranolol group, and Glytan group, according to their weight. PHT and liver fibrosis were induced by common bile duct ligation. After 2 and 4 weeks, the hydroxyproline (Hyp) content of liver tissues was tested by spectrophotometer. The collagen formation was evaluated by Masson staining and ultrastructural changes were evaluated by transmission electron microscopy (TEM). The results showed that Glytan inhibited the Hyp production at 2 weeks and 4 weeks. Masson staining revealed the same results with Hyp. Glytan inhibited the pseudolobule formation. TEM showed swelling sinusoid endothelial cells (SEC), reduced fenestra between the SEC, widened Disse's space, and reduced hepatocyte microvilli in the model group rats. At 4 weeks, loss of the hepatocyte microvilli and the basement membrane were clearly seen. Glytan promoted degeneration of the matrix and restoration of the SEC at 2 weeks and 4 weeks. It was concluded that Glytan inhibited collagen formation and ameliorated sinusoidal capillarization. This is one of the mechanisms of Glytan used to decrease the portal venous pressure. The results provided precise and reliable proof to develop new treatments for PHT.

      PubDate: 2013-04-18T08:02:34Z
       
  • Preliminary Analysis of the Discipline from Yan Zhenghua's Prescription
           for the Treatment of Stomach Pain Based on Natural Medicine Combination
           Modes
    • Abstract: Publication date: June 2012
      Source:World Science and Technology , Volume 14, Issue 3
      Author(s): Li Meng , Gu Hao , Zhai Huaqiang , Xiao Bin , Wang Yun
      Medicinal prescription is one of the important criteria for the compatibility of Chinese medicine. This article analyzes the herbal medicine combination prescribed by Prof. Yan Zhenghua, a national Chinese medicine expert, for the treatment of stomach pain. Prof. Yan has explored research methods for the compatibility of Chinese medicine based on the natural medicine combination modes. The corresponding prescription database of existing prescriptions has been established. Algorithms for association rules were used in the analysis of combination modes of Yan Zhenghua's prescription for the treatment of stomach pain. The results revealed the prescription characteristics of Yan Zhenghua's treatment of stomach pain. This study puts forward new ideas based on the prominent doctor's academic views.

      PubDate: 2013-04-18T08:02:34Z
       
  • Correction
    • Abstract: Publication date: June 2012
      Source:World Science and Technology , Volume 14, Issue 3


      PubDate: 2013-04-18T08:02:34Z
       
  • Discussion on Establishment of Brain Interstitial Fluid Pharmacology based
           on Microdialysis
    • Abstract: April 2012
      Publication year: 2012
      Source:World Science and Technology , Volume 14, Issue 2

      Brain interstitial fluid (BIF) is a biological matrix of cerebral neurons. The medicine composition that is permeated into the brain and the endogenous substances released into synaptic space are available in BIF, which make it an ideal vehicle for research on drug targeting and an efficacious mechanism of neuroprotective medicine. Based on the microdialysis sampling technique, BIF can be used in not only in vivo studies but also in vitro experiments. On the basis of serum pharmacology, the concept of BIF pharmacology was proposed by our team. This article also discusses the feasibility and advantages of BIF pharmacology application in Chinese medicine prescription. This new mode of study serves as a creative attempt of facilitating the international orientation of Chinese medicine.

      PubDate: 2012-12-15T09:54:02Z
       
  • Research Thoughts and Methods on Concise Prescriptions of Chinese Medicine
           for Prevention and Treatment of Alzheimer's Disease based on Various Kinds
           of Animal Models
    • Abstract: April 2012
      Publication year: 2012
      Source:World Science and Technology , Volume 14, Issue 2

      In the theory of traditional Chinese medicine (TCM), the key pathogenesis of Alzheimer's disease (AD) was kidney-essence deficiency, and this resulted in phlegm stasis. So, in clinical practice, concise prescriptions that consist of herbs, which reinforce kidney qi, activate blood circulation, and detoxicate, exert a good effect on the AD treatment. Based on various kinds of animal models, this article discussed the pharmacological effects of concise prescriptions of Chinese medicine on AD prevention and treatment. The preparation technology and composition of concise prescriptions of Chinese medicine were determined based on the combination of Chinese medicine preparation technology and the efficacy evaluation of the drugs. According to the complex pathogenesis of AD, we developed a basic research method using concise prescriptions prepared by different technologies and various animal models of AD. Changes in some advanced indicators were observed as reflecting the pathological and physiological characteristics of AD and the pharmacodynamic effects of prescriptions. The formation of a safe and effective concise prescription is able to comprehensively reflect the pathogenesis and characteristics of AD based on various kinds of animal models.

      PubDate: 2012-12-15T09:54:02Z
       
  • Complex Systems Entropy Network and Its Application in Data Mining for
           Chinese Medicine Tumor Clinics
    • Abstract: April 2012
      Publication year: 2012
      Source:World Science and Technology , Volume 14, Issue 2

      This study was aimed at investigating the method of data mining for complex Chinese medicine tumor clinical data. This article introduces a complex systems entropy network for data mining in tumor clinics. A mutual information algorithm based on the random permutation test was proposed for assessing the correlation of multi-variables, and a complex network was established. Based on the tumor clinical data (718 cases) collected, data mining was performed with the help of the statistical information of the complex network. The results showed that interaction effects among multi-variables were discovered by a complex systems entropy network. A total of 116 pairs of synergy variables and 14 core synergy cliques, 82 pairs of antagonistic variables and 7 core antagonistic cliques were found after 718 cases of data mining. The results, for the most part, correspond with the actual clinics. It was concluded that the complex systems entropy network is suitable for the analysis of interaction effects among multi-variables and also for data mining in complex Chinese medicine clinics.

      PubDate: 2012-12-15T09:54:02Z
       
  • Establishment of Disease-syndrome Combination Rat Model of Rheumatoid
           Arthritis with Spleen Deficiency
    • Abstract: April 2012
      Publication year: 2012
      Source:World Science and Technology , Volume 14, Issue 2

      This study was aimed at establishing a disease-syndrome combination rat model of rheumatoid arthritis (RA) with spleen deficiency. A group of 60 six-week-old SpragueDawley rats were randomly divided into normal control group and reserpine (RSP) group. Spleen deficiency model rat groups were made by an intraperitoneal injection of RSP. After 14 days, rats of RSP groups were subcutaneously injected with collagen type II protein to induce arthritis. The incidence of the model was observed, and the mechanism was analyzed by enzyme-linked immunosorbent assay (ELISA). The results showed that compared with the collagen-induced arthritis (CIA) group, the degree of joint swelling and joint damage was significantly increased in the RSP CIA model. The RSP CIA model rats were observed as exhibiting spleen deficiency syndrome that was similar to clinical symptoms, such as appearing apathetic, squinting, a sparse dry dull coat, a bowed back, a swollen ankle, fatigue, lazy movement, getting together, eating less, weight loss, and loose stools. Compared with the CIA control rats, spleen deficiency impaired the function of intestinal mucosa by disordering the intestinal villi, covering a large amount of goblet cells in the epithelium, and inducing exfoliation, degeneration, and necrosis fluff pieces. The content of anti-type II collagen antibody, IL-6, IL-10, and IFN-γ was increased. It was concluded that the rat model of rheumatoid arthritis with spleen deficiency syndrome by an intraperitoneal injection of reserpine has both obvious spleen deficiency syndrome and characteristics of RA. It can provide successful experiences for the rat model of rheumatoid arthritis with spleen deficiency syndrome. Spleen deficiency plays a vital role in RA.

      PubDate: 2012-12-15T09:54:02Z
       
  • Development of Mesoscopic Simulation Studies on Nonionic Block Copolymer
           Surfactants
    • Abstract: April 2012
      Publication year: 2012
      Source:World Science and Technology , Volume 14, Issue 2

      Nonionic block copolymer surfactants, possessing a low stimulation and a low toxicity, have been widely used as pharmaceutical excipients. Studies are conducted on surfactants mainly through experiments. However, through this method, it is difficult to study the solubilization mechanism of surfactants. Mesoscopic simulation, with a shorter period and a lower cost, was beneficial for the study of mechanisms; provided guidelines for experiments and applications; and was, thus, favored by researchers. In recent years, numerous studies have been carried out on nonionic block copolymer surfactants. This article reviewed the effect of mesoscopic simulations on nonionic block copolymer surfactants, aiming at providing an effective method for the study on the mechanism and application of nonionic block copolymer surfactants.

      PubDate: 2012-12-15T09:54:02Z
       
  • Effect of Shear Rate on the Aggregation Behavior of Self-Aggregated
           Glycyrrhizin Micelles by MesoDyn
    • Abstract: February 2012
      Publication year: 2012
      Source:World Science and Technology , Volume 14, Issue 1

      MesoDyn has been carried out to elaborate the micellar properties of natural surfactant glycyrrhizin which is frequently used in traditional Chinese medicine (TCM). The effect of shear rate on the aggregation behavior of glycyrrhizin has been investigated. The results showed that the critical micelle concentration (CMC) of glycyrrhizin increased with the addition of shear rate. And the glycyrrhizin aggregation transformed from spherical micelle to cylindrical micelle as the increase of shear rate. Furthermore, the aggregation behavior of the as-formed micelle was not stable to the change of shear rate. Removal of shear rate was unable to recover the micelle completely in the changing process of shear rate. The simulation results provide mesoscopic information for the solubilization of poorly water-soluble drug, and at the same time provide guidance for high efficient experiments.

      PubDate: 2012-12-15T09:54:02Z
       
  • Pharmacokinetics of Isofraxidin in Extracellular Fluids of Striatum in
           Rats Using Microdialysis-UPLC Method
    • Abstract: February 2012
      Publication year: 2012
      Source:World Science and Technology , Volume 14, Issue 1

      This study aimed to observe the pharmacokinetic characteristics of isofraxidin in extracellular fluids of striatum in rats after oral administration of isofraxidin. Microdialysis and UPLC-MS analytical technology were used in this study to detect the concentration of isofraxidin in microdialysis dialysate of extracellular fluids of striatum in rats, within 60 min after a single oral administration, with isofraxidin of 10 and 20 mg/kg, respectively. The results were revised by relative recovery in vivo. The pharmacokinetic parameters were calculated through noncompartment model method with software of WINONLIN 6.1 program. The main pharmacokinetic parameters of isofraxidin in extracellular fluids of striatum in rats after a single oral administration of isofraxidin at 10 mg/kg and 20 mg/kg were AUC0-∞ (13973.88 ± 1582.984) and (28059.76 ± 4207.66) ng·min/mL; t1/2 (16.68 ± 0.49) and (17.41 ± 2.88) min; Cmax(498.87 ± 64.36) and (899.81 ± 133.22) ng/mL. The tmax of both two groups was 15 min. Both the Cmax and tmax were measured. It was concluded that isofraxidin quickly permeates the bloodbrain barrier and reaches the striatum. The maximal concentration of isofraxidin is 15 min after oral administration. And then the concentration decreases at a faster rate. It showed a significant dose-dependent phenomenon of the concentration of isofraxidin in extracellular fluids of striatum in rats.

      PubDate: 2012-12-15T09:54:02Z
       
  • Study on Preparation and in Vitro Sustained Release of Bu-Yang-Huan-Wu
           Sustained-Release Tablet
    • Abstract: February 2012
      Publication year: 2012
      Source:World Science and Technology , Volume 14, Issue 1

      Aim of this study was to prepare Bu-Yang-Huan-Wu (BYHW) elementary osmotic pump sustained-release tablets and to investigate the situation of its main effective components of “synchronous control and sustained release.” The releasing similarity of chromatographic fingerprints of BYHW in vitro dissolution was evaluated. The results showed that BYHW elementary osmotic pump sustained-release tablet was prepared and the chromatographic fingerprints were extracted. And data of its release similarity was also obtained. It was concluded that BYHW elementary osmotic pump sustained-release tablet can achieve the synchronous control and sustained release of many ingredient. It is also fit for the characteristic of Chinese herbal medicine compound.

      PubDate: 2012-12-15T09:54:02Z
       
  • Exploring the Rules of Chinese and Western Medicine Used in the Treatment
           of Osteoporosis by Text Mining
    • Abstract: February 2012
      Publication year: 2012
      Source:World Science and Technology , Volume 14, Issue 1

      This study was aimed at exploring the rules of Chinese patent medicine and Western medicine, as well as their combination rules used in the treatment of osteoporosis by text mining. Data on osteoporosis were queried and downloaded from SinoMed in March 2011. After transferring semi-structured data into the Microsoft SQL Server, the algorithm of data slicing based on frequency analysis was applied. A few simple, meaningful networks were achieved. The data of these networks were imported into Cytoscape and visualized. The results showed that in the treatment of osteoporosis, Chinese patent medicines, such as Zuogui pills, Liuwei Dihuang pills, Gusongbao granules, Yougui pills, and Shengu capsules, are widely used in the clinical practice. Chinese herbal medicines, such as Herba Epimedii, Radix Rehmannia, Radix Astragali, Rhizoma Drynariae, Salvia Miltiorrhiza, Fructus Psoraleae, Radix Puerariae, Radix Angelica, and Cortex Eucommiae, are frequently dealt with in articles on osteoporosis. Herba Epimedii and Radix Rehmannia are major herbal medicines that are most frequently used in the herbal combination. The most important treatment method of treating osteoporosis is by strengthening the kidney and spleen by activating and nourishing blood. Among all Western medicines, estrogen agents, Vitamin D, calcium, and thyrocalcitonin are the most frequently used in the treatment of osteoporosis. In this article, the rules pertaining to Chinese patent medicine and Western medicine used in the treatment of osteoporosis were described. The combination of Chinese patent medicine and Western medicine was also calculated for the clinical application and basic research reference.

      PubDate: 2012-12-15T09:54:02Z
       
  • Clinical Research on TCM Syndrome Differentiation of 218 Patients with
           Postoperative Colorectal Cancer
    • Abstract: December 2011
      Publication year: 2011
      Source:World Science and Technology , Volume 13, Issue 6

      This study aimed at providing objective and scientific evidence in the treatment determination of postoperative colorectal cancer based on the pathogenesis obtained through traditional Chinese medicine (TCM) syndrome differentiation. The symptoms and signs of postoperative early metaphase colorectal cancer were objectively summarized and differentiated by TCM syndrome differentiation. Mathematical statistics and multivariate analysis were applied in the clinical research. A total of 218 patients with postoperative early metaphase colorectal cancer were investigated in both Beijing and Shanghai. The contents included common data, TNM staging, the grade of oncopathology, previous treatment, symptoms, physical signs, and the TCM syndrome differentiation pattern. The database was established and managed with EPIdata 3.1. The data were entered twice in the auditing. The main statistical method employed was multivariate analysis, including cluster analysis and factor analysis. Regular TCM syndrome patterns of postoperative early metaphase colorectal cancer were objectively summarized by mathematical statistics and in combination with clinical practice. Through a clinical investigation and mathematical statistics, the diagnostic criteria of the TCM syndrome differentiation of postoperative early metaphase colorectal cancer were initially made. The seven determined TCM syndrome patterns are the syndrome of dryness of the intestine, the syndrome of insufficiency of the spleen and stomach, the syndrome of deficiency and exhaustion of spleen-qi, the syndrome of deficiency and exhaustion of liver-yin and endoretention of damp heat, the syndrome of inco-ordination between the liver and stomach, the syndrome of deficiency and exhaustion of kidney-qi, and the syndrome of yang asthenia and phlegmatic hygrosis. Meanwhile, the major as well as minor symptoms were also defined in each of these seven patterns. It is concluded that according to the results of mathematical statistics in combination with TCM theories, there are rules in the TCM syndrome patterns of postoperative early metaphase colorectal cancer. Further studies should be conducted in this area.

      PubDate: 2012-12-15T09:54:02Z
       
  • Kappa Analysis on the Application of Selecting Traditional Chinese
           Medicine Five-Element Music under Syndrome Differentiation
    • Abstract: December 2011
      Publication year: 2011
      Source:World Science and Technology , Volume 13, Issue 6

      The quality of traditional Chinese medicine (TCM) five-element music was evaluated and selected under syndrome differentiation by using the Kappa test. Two different Kappa values between the physician and the cancer patient were compared in order to analyze the interconsistency of TCM five-element music selection. A total of 73 hospitalized cancer patients were allocated to receive TCM five-element music. The results of a single tune selection showed that a Kappa value greater than 0.4 for four modals, with moderate degree of consistency and statistical consistent for each other. However, there was neither consistent measurement nor statistical consistency for the Zhi tune. Multi-modal music selection showed that a Kappa value greater than 0.4 was related to heart-kidney deficiency, heart-spleen deficiency, liver-kidney deficiency, lung-kidney deficiency, and lung-spleen deficiency in modal choice. There was a moderate degree of statistical consistency. It was concluded that a consistency of TCM five-element music selection was observed between physician and patient by using the Kappa analysis. The study laid a good foundation for TCM five-element music for cancer patients.

      PubDate: 2012-12-15T09:54:02Z
       
  • Influencing Factor Analysis on Hospitalization Costs of 3046 Cases with
           Colorectal Cancer on Basic Medical Insurance in Beijing
    • Abstract: December 2011
      Publication year: 2011
      Source:World Science and Technology , Volume 13, Issue 6

      The hospitalization cost of patients with colorectal cancer was studied to reveal influencing factors to explore traditional Chinese medicine (TCM) hospital performance characteristics, distribution law of factors affecting costs, and proposal of reducing medical costs. Retrospective analysis was conducted on the data of 3046 cases with colorectal cancer on basic medical insurance in Beijing in 2008. Factors of medical quality and costs were investigated by single and multivariate analysis. The relation of different factors and hospitalization cost was discussed. The results showed that major factors influencing hospitalization costs were hospitalization days, hospital category, main diag- nosis, hospital rank, operation or not, combination with cardiocerebral diseases, etc. It was concluded that hospitalization costs can be reduced by promoting applied rate of TCM, shortening hospitalization duration, promoting level of diagnosis and treatment, and service quality.

      PubDate: 2012-12-15T09:54:02Z
       
  • Research Status and Methods of Rationality of Daily Oral Administration
           Times of Traditional Chinese Medicine Preparations
    • Abstract: December 2011
      Publication year: 2011
      Source:World Science and Technology , Volume 13, Issue 6

      The rationality of daily oral administration times of traditional Chinese medicine (TCM) is a key scientific problem on its safety and efficacy in clinical application. In this article, the current research situation and essentiality of daily oral administration times of TCM were stated. One evaluation pattern was put forward on the basis of pharmacodynamic/pharmacokinetic (PD-PK) and mainly on the basis of pharmacodynamic biomarkers (PD-Markers).

      PubDate: 2012-12-15T09:54:02Z
       
  • Effects of Zibu Piyin Recipe on Endoplasmic Reticulum Stress in the Brain
           Tissue of Spleen-Yin Deficiency Alzheimer's Disease Rats
    • Abstract: December 2011
      Publication year: 2011
      Source:World Science and Technology , Volume 13, Issue 6

      The effects of Chinese herbs for Zibu Piyin Recipe (ZBPYR) on spleen-Yin deficiency Alzheimer's Disease (AD) rats were investigated. A new rat model was established based on both AD and the spleen-Yin deficiency syndrome. Then, expressions of glucose- regulated protein78 (GRP78), CCAAT/EBP homologous protein (CHOP) in the hippocampus (CA1, CA3, and DAG regions) and cerebral cortex that were correlated to endoplasmic reticulum stress were determined. The results showed that in contrast to the Spleen-Yin Deficiency AD groups, the expression of the GRP78 protein was obviously upregulated (P < 0.05) in the ZBPYR group; whereas the expression of the CHOP protein was obviously downregulated (P < 0.05). It is concluded that Chinese herbs for ZBPYR improve the ability of learning and memory by reinforcing the survival pathway of ERS, and inhibiting the apoptosis pathway of ERS.

      PubDate: 2012-12-15T09:54:02Z
       
  • Thoughts on Sustainable Development of Chinese Medicine Industry in
           “High Concept” Era
    • Abstract: October 2011
      Publication year: 2011
      Source:World Science and Technology , Volume 13, Issue 5

      With a rapid shift from the “Information Age” to the “Conceptual Age,” creative thinking in the “High Concept” era has been advocated for the human society. The large Chinese medicine industry, as the most original thought, is an integral part of Chinese medicine. The question of the entire industry is how to adapt it to time and achieve sustainable development. According to the requirements for sustainable development of Chinese medicine industry in the era of “High Concept,” eight measures have been proposed. The strategies are as follows: to rationalize the standard management system and increase industry consolidation layout; to intensify policy support, strengthen and expand its Chinese brand; to speed up basic medical research and promote traditional Chinese medicine (TCM); to enhance cultivation of leading enterprises and strengthen TCM industry; to speed up innovations in order to guide and promote effective transformation of technical results; to develop conservation strategies and deal with the impact of “foreign Chinese medicines”; to promote multidisciplinary consortium and play advantage of talent from overseas; to encourage enterprises in the international market and enhance international competitiveness of Chinese medicine.

      PubDate: 2012-12-15T09:54:02Z
       
  • Discussion on the Laws of Traditional Chinese Medical Treatment of H1N1
           Influenza Based on a Cohort Study
    • Abstract: October 2011
      Publication year: 2011
      Source:World Science and Technology , Volume 13, Issue 5

      This article was aimed at discussing the laws of compound medicine application of traditional Chinese medicine (TCM) in the treatment of influenza A (H1N1). Data on 4037 influenza A (H1N1) cases were collected in a multicenter cohort study using compound TCM treatment during the influenza A (H1N1) outbreak in Guangzhou from December 2009 to April 2010. The laws of TCM compound medicine application were summarized based on syndrome differentiation. The results showed that 156 kinds of Chinese herbs were used: heat-clearing and detoxifying medicinal, cough-suppressing, phlegm-relieving and panting-calming medicinal, wind-cold dispersing medicinal, wind-heat dispersing medicinal, heat-clearing and fire-purging medicinal. These medicinal occupy 51.90% in the prescription. Twenty-eight kinds of TCM medicinals were commonly used. The channel tropism involved 12 channels. The main channels were the Lung meridian, Stomach meridian, Heart meridian, and Liver meridian. The proportion of these medicinals occupies 78.71%, and all medicinals cover 7 kinds of tastes. The top three tastes are bitter, sweet, and pungent. Their proportion was 99.57%. The top 10 commonly used TCM medicinals (except for RADIX GLYCYRRHIZAE) were RADIX PLATYCODONIS, FRUCTUS FRUCTUS FORSYTHIAEE, FLOS LONICERAE, FOLIUM MORI, RHIZOMA PHRAGMITIS, HERBA MENTHAE, FLOS CHRYSANTHEMI, HERBA LOPHATHERI, FRUCTUS ARCTII, and SEMEN ARMENIACAE AMARUM. The most frequently used prescription in the group of expelling exogenous wind heat was Yin-Qiao Powder. The prescription of expelling exogenous wind cold was Jing-Fang-Bai-Du Powder. The frequency of using Ma-Xing-Shi-Gan Decoction to remove toxic heat blocking in the lungs was approximately 100%. It is concluded that the efficacy, taste, channel tropism, and compatibility of the TCM medicinals used in the treatment of H1N1 flu were closely related to the etiological factor and the pathogenesis of Influenza A (H1N1).

      PubDate: 2012-12-15T09:54:02Z
       
  • Quantum Chemistry Calculation on Demethylated Metabolites of Aconitine
    • Abstract: October 2011
      Publication year: 2011
      Source:World Science and Technology , Volume 13, Issue 5

      This study was aimed at evaluating the metabolites of aconitine by quantum chemistry calculation. The geometries of possible metabolites were optimized by using the density functional theory at B3LYP/6-31G(d) level. The energies of possible metabolites and hydrolysis reactions were obtained. Solvation effects were calculated by using IEFPCM. A comparison among the four possible reaction energies showed that the metabolites of aconitine were identified as 16-O-demethylaconitine and 16-O-demethylbenzoylaconine. The energy difference of possible metabolites was increased in the aqueous solution. It was concluded that the metabolites identified by quantum chemistry calculation are the same as those deduced by fragmentation regularity of mass spectrometry. Metabolites of aconitine can be studied by a combination of HPLC-MSn and quantum chemistry calculation.

      PubDate: 2012-12-15T09:54:02Z
       
  • Association Analysis on Pulse Graph Characters of Coronary Heart Disease
           and Its Blood-Fat and Thrombin
    • Abstract: October 2011
      Publication year: 2011
      Source:World Science and Technology , Volume 13, Issue 5

      The study was aimed at exploring the relationship between pulse graph characters and its blood-fat and thrombin among coronary heart disease (CHD) patients. Pathological and physiological indexes had been searched for correlation with pulse graph parameters. Pulse detection system was applied in the collection of pulse graph among CHD patients, and pulse characters were analyzed with time domain method. Blood-fat and thrombin indexes were checked. Canonical correlation was used in the analysis of relationship between pulse graph characters and its blood-fat and thrombin in CHD patients. The results showed that, among the ingredients of blood-fat, change in low-density lipoprotein was closely related to t and t5/t4 of pulse graph in CHD. They were positively correlated. There was no obvious correlation between pulse graph characters and thrombin indexes. However, it was concluded that some correlation exists between the parameters of pulse graph and blood-fat indexes.

      PubDate: 2012-12-15T09:54:02Z
       
  • Study on the Effects of Curculigoside on Proliferation, Differentiation,
           and Calcification of Mouse Osteoblastic MC3T3-E1 Cells
    • Abstract: October 2011
      Publication year: 2011
      Source:World Science and Technology , Volume 13, Issue 5

      This study was aimed at evaluating the effects of Curculigoside (CCG) on the proliferation, differentiation, and calcification of mouse osteoblastic MC3T3-E1 cells. MTT assay was applied in the evaluation of MC3T3-E1 cell proliferation with CCG at different doses for different incubation periods. Alizarin red staining method was applied to observe the effect of CCG on the bone nodule formation of cells. The differentiating effects of CCG with different concentrations in cells were evaluated through the examination of alkaline phosphatase (ALP) activities by PNPP. The results showed that CCG is effective in promoting the proliferation of MC3T3-E1 cells cultured for 24 h, 48 h, and 72 h at doses ranging from 10−4 mol·L−1 to 10−8 mol·L−1. CCG at the concentration of 10−9 mol·L−1 remarkably increased the bone nodule formation of cells. The activity of ALP was stimulated by CCG at doses of 10−7 mol·L−1 and 10−9 mol·L−1 after 96 h of incubation. It was concluded that CCG has effects on stimulating the proliferation, differentiation, and calcification of MC3T3-E1 cells.

      PubDate: 2012-12-15T09:54:02Z
       
  • Design and Development of Pharmaceutical Excipients Database
    • Abstract: August 2011
      Publication year: 2011
      Source:World Science and Technology , Volume 13, Issue 4

      Pharmaceutical excipients database (PED) was established on the basis of MDL ISIS/Base Database Management System (DMS). Currently, 270 pharmaceutical excipients were included. The pharmaceutical excipients database consists of three tables. The first table is basic information that contains 17 attributes in total, such as Chinese and English names of excipients and so on. The second table is the basic property table that contains physical and chemical properties and so on. There are 11 attributes in total. The third table is the computed property that was calculated by the Synthia module of Materials Studio 4.1. The PED not only provides great convenience for the query of pharmaceutical excipients, but also serves as a data mining platform for the pharmaceutical excipients.

      PubDate: 2012-12-15T09:54:02Z
       
  • Study on Proteinum in Clear Supernatant Liquid of Tongue Coating of
           Chronic Renal Failure Based on Protein Chip
    • Abstract: August 2011
      Publication year: 2011
      Source:World Science and Technology , Volume 13, Issue 4

      This study aimed at screening proteinum markers of tongue coating related to chronic renal failure (CRF) and at establishing the predictive model by comparing differences of protein spectrum expression in clear supernatant liquid of tongue coating between CRF patients and normal controls in order to explore the significance of proteinum in clear supernatant liquid in the diagnosis of CRF. Clear supernatant liquid of tongue-coating samples collected from 67 CRF patients and 38 normal controls was used in the study. The proteinum markers of tongue coating were selected according to CRF with the SELDI-TOF-MS technique. The predictive model was established and verified by bioinformatics analysis. The tongue-coating samples of the 67 CRF patients and 38 normal samples in the control group were determined by the SELDI-TOF-MS technique. All 242 proteinum peaks were detected at 1000–20000 e/m. Overall, 13 distinct mass spectrum peaks were analyzed by bioinformatics and displayed statistical significance (P < 0.01). Seven distinct mass spectrum peaks, such as M/Z1092.68 and M/Z1508.26, show high expression in the CRF group. Six distinct mass spectrum peaks, such as M/Z13302.5 and M/Z14330.7, show low expression in the CRF group. Fuzzy-grouping algorithm was used in the fuzzy-grouping analysis and principal component analysis (PCA) between the CRF group and normal control group. The result showed discrimination, but was partly overlapping. The predictive model of CRF was analyzed and established by bioinformatics with biological markers that comprise seven distinct mass spectrum peaks, such as M/Z1049.61, M/Z1076.94, M/Z15295.7, and so on. The predictive model can be used in the sample classification between the CRF group and normal control group (The sensitivity of the predictive model is 61.4%; the specificity is 57.3%; and the predictive exactitude rate is 64.4%). It can be concluded that using the SELDI-TOF-MS technique, the proteinum markers of tongue coating of CRF have been preliminarily screened. The established predictive model provides objective evidence for the study on CRF diagnosis.

      PubDate: 2012-12-15T09:54:02Z
       
  • Study on the Nature of Spleen Qi Deficiency Based on Metabonomics
    • Abstract: August 2011
      Publication year: 2011
      Source:World Science and Technology , Volume 13, Issue 4

      This study aimed at analyzing small molecule metabolites c in plasma in order to find the spectra of plasma in metabolic syndromes (MS) of spleen qi deficiency, which is different from other kinds of deficiency. The basic documents related to subjects were collected in combination with the diagnostic criteria of metabolic syndrome and spleen qi deficiency. UPLC-Q-TOF-MS was used in the separation of plasma metabolites. The results showed that the spectrum of plasma in MS of the spleen qi deficiency is different from healthy subjects in metabonomics (P < 0.05). It is concluded that three compounds are possibly the latent markers of MS; another three compounds may be the potential markers of the spleen qi deficiency.

      PubDate: 2012-12-15T09:54:02Z
       
  • Experiments on Antitumor Activity and Immunological Mechanisms of
           Scutellaria Barbata Polysaccharides
    • Abstract: August 2011
      Publication year: 2011
      Source:World Science and Technology , Volume 13, Issue 4

      This research aimed at studying the antitumor activity and immunological mechanisms of Scutellaria barbata polysaccharides (SBPS). Hepatocarcinoma H22-bearing mice were randomly divided into negative control group, SPS group, and polyporus polysaccharide group. After the drug administration for 10 consecutive days, the inhibitory rate of tumors, thymus index, and spleen index, and the phagocytic function of macrophages were observed. ELISA method was used in the determination of the serum level of IL-2. The comparison was made among the groups. The results showed that SPS can effectively inhibit the growth of HepA. The inhibitory rate of tumors was 34.35%. The weight of immune organs was also increased among HepA-bearing mice. The serum level of IL-2 and the phagocytic function of macrophages were also increased. Thus, it can be concluded that SPS has obvious antitumor activity. The mechanism is due to the enhancement of the immune function.

      PubDate: 2012-12-15T09:54:02Z
       
  • Determination of Anthraquinones by UPLC Method in Patient with
           Craniocerebral Injuries after Oral Administration of Rhubarb
    • Abstract: August 2011
      Publication year: 2011
      Source:World Science and Technology , Volume 13, Issue 4

      Ultra-high performance liquid chromatography (UPLC) method was developed for determining anthraquinones in plasma of patient with craniocerebral injuries after administration of Rhubarb. Chromatographic separation was performed on an Acquity UPLC BEH C18 column (2.1 mm × 100 mm, 1.7 μm) with methanol-0.5% aqueous acetic acid (12:82) as mobile phase at a flow rate of 0.5 mL·min−1. The wavelength was set at 254 nm. The operating temperature was maintained at 25°C and the sample volume injected was 5 μL. Linear range was satisfactory for determination of rhein in human plasma with the concentration ranging from 0.42 to 13.429 μg·mL−1. Four other anthraquinones were not detected using UPLC method. Recovery rate of this method was within the range of 97.2%−103.11%. The relative standard deviation of intra- and inter-day was less than 6%. The concentration of rhein in plasma after 1 hour administration from five TBI patients was 7.93±1.94 μg·mL−1. The UPLC is a method with good precision, high recovery rate, simple operation, innocuity, and good reproducibility.

      PubDate: 2012-12-15T09:54:02Z
       
  • Analysis and Thinking on the Current Status of Traditional Chinese
           Medicine Standardization
    • Abstract: June 2011
      Publication year: 2011
      Source:World Science and Technology , Volume 13, Issue 3

      Standard is one of basic elements that constitutes core competitive power of a country. It is also an important technical system for normalizing economy and social development. This study emphasizes on the importance of enforcing traditional Chinese medicine (TCM) standardization, and summarizes the achievement, analyzes the problems, and provides the corresponding measures for settling the problems.

      PubDate: 2012-12-15T09:54:02Z
       
  • New Problems of Intellectual Property during Innovation of Traditional
           Chinese Medicine
    • Abstract: June 2011
      Publication year: 2011
      Source:World Science and Technology , Volume 13, Issue 3

      Innovation of Traditional Chinese medicine (TCM) was proposed under market economy conditions. Hence, not only rules of market economy but also intellectual property law must be complied with. Innovation of TCM can be divided into two parts. One is the self innovation of TCM and the other is innovation based on knowledge and techniques of TCM. Both innovations have been presented with different questions of intellectual property derived from past events. Under market economy conditions where private rights are legitimate and interests must be maximized, a proper intellectual property legal system should be established for the innovation of TCM to protect and maintain this superior domain of China.

      PubDate: 2012-12-15T09:54:02Z
       
  • Effect of Zhichan Decoction on Neural Stem Cell Differentiation in
           Parkinson's Disease Model Rats
    • Abstract: June 2011
      Publication year: 2011
      Source:World Science and Technology , Volume 13, Issue 3

      This study was aimed at discussing the effect of Zhichan decoction (ZCD) on neural stem cell (NSC) differentiation in Parkinson's disease (PD) model rats. PD model rats were divided into four groups. In the normal group and model group, 0.9% normal saline was administered intragastrically. Normal culture medium was transplanted in the brain. ZCD was administered intragastrically in the treatment group after NSC transplantation. TH protein was checked with the immunohistochemical method, and mRNA expression of Ptx3, Nurrl, and Shh was checked with RT-PCR from brain slices on 7 d, 14 d, and 28 d, respectively. The results showed that TH protein was significantly increased in the treatment group on 7 d and 14 d as compared with the control group. The mRNA expression of Ptx3 and Shh was significantly increased at some time points. It is concluded that ZCD has the effect of promoting NSC differentiation in PD model rats.

      PubDate: 2012-12-15T09:54:02Z
       
  • Empirical Study of Proteome of Hippocampus from A Rat Model with
           Alzheimer's Disease with Spleen Deficiency Syndrome Effected by Zibu Piyin
           Recipe
    • Abstract: June 2011
      Publication year: 2011
      Source:World Science and Technology , Volume 13, Issue 3

      The article is aimed at investigating Alzheimer's disease (AD) with spleen yin deficiency syndrome and identifying the effective therapeutic targets of Zibu Piyin Recipe (ZBPYR) at whole cell protein levels. The rat model of spleen yin deficiency syndrome was set up through combination with improper diet, overstrain, and consumption of body fluid. Then, the polymerized β-amyloid 1–40 was injected into both hippocampi of the rats. The treated group was administered with ZBPYR. Taking the control group as a standard, the changes of proteins in the hippocampus were compared between the model group of AD with spleen yin deficiency syndrome and ZBPYR-treated group by two-dimensional gel electrophoresis. The altered protein spots were analyzed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS). Compared with the control group, 9 protein spots of the hippocampus in the model group of AD with spleen yin deficiency syndrome and 2 spots in ZBPYR-treated group were found to be changed totally. The differential protein spots were identified by MALDI-TOF-MS. The results showed that in the model group of AD with spleen yin deficiency syndrome, the level of annexin III was higher, but the levels of tubulin beta chain 15, dihydropyrimidinase-like 2, and guanine nucleotide-binding protein beta-1 subunit were lower than that of the control group. These differential proteins did not show significant changes between the ZBPYR-treated group and the control group. It is concluded that changes of several proteins in the hippocampus may involve in the pathogenesis of AD with spleen yin deficiency syndrome together. Annexin III, tubulin beta chain 15, dihydropyrimidinase-like 2, and guanine nucleotide-binding protein beta-1 subunit are possibly related to pathological changes of the hippocampus in AD with spleen yin deficiency syndrome. ZBPYR may produce its effects by regulating these proteins in the hippocampus.

      PubDate: 2012-12-15T09:54:02Z
       
  • Effects of Tongluo-Jiunao Injection on Cerebral Ischemia–Reperfusion
           Injury Rats
    • Abstract: June 2011
      Publication year: 2011
      Source:World Science and Technology , Volume 13, Issue 3

      The aim of this study was to investigate the protective effects of Tongluo-Jiunao (TLJN) injection on brain tissues of focal cerebral ischemia-reperfusion injury rats. Cerebral ischemia-reperfusion injury rat model was established by middle cerebral artery occlusion. All animal models were divided into the following four groups: sham, model, TLJN, and edaravone groups. The brain infarct volume, concentration of IGF-1 in brain tissues and serum were detected at 24 h, 3 d, and 7 d after cerebral ischemia-reperfusion injury. The results showed that compared to the model group, the brain infarct volume of TLJN group was significantly reduced, and the expression of IGF-1 of cerebral cortex was upregulated in TLJN group. It was concluded that TLJN has significant protective effects on brain tissues in focal cerebral ischemia-reperfusion injury rat, and the IGF-1 may play an important role in the protective effects of brain tissues.

      PubDate: 2012-12-15T09:54:02Z
       
  • Role of Platelet-Monocyte Aggregation in the Onset of Acute Cardiovascular
           and Cerebrovascular Diseases
    • Abstract: June 2011
      Publication year: 2011
      Source:World Science and Technology , Volume 13, Issue 3

      Atherosclerosis is the main pathological basis of cardiovascular and cerebrovascular diseases. Adhesion and aggregation of platelet and monocyte play an important role in patients with acute cardiovascular and cerebrovascular diseases. This article reviews the molecular mechanism of aggregation formation, mechanism of inducing plaque rupture, pathogenesis of impacting acute cardiovascular and cerebrovascular disease occurrence, targets of Chinese medicine and western medicine, corresponding monoclonal antibodies and gene knockout, etc. Problems that existed in the current study are also analyzed to arouse the attention of fellow researchers.

      PubDate: 2012-12-15T09:54:02Z
       
  • Gut Microbiota-targeted, Whole-Body Systems Biology for Understanding
           Traditional Chinese Medicine
    • Abstract: April 2011
      Publication year: 2011
      Source:World Science and Technology , Volume 13, Issue 2

      Traditional Chinese medicine (TCM) is a medical system with its own theoretical framework focusing on functions at the whole-body level, and it has accumulated abundant clinical experience. However, TCM approaches are empirical, and the manifestations that it reads in human bodies can hardly be communicated in molecular language with modern medicine. Whole-body systems biology considers the human body as a “superorganism,” which consists of cells of both human and symbiotic microorganisms. Taking advantage of “-omic” technologies, biological information in urine, fecal, and blood samples can be profiled as emergent functions of the complex human system for understanding its dynamics in disease and health. This top-down systems biology approach emphasizes the functions of gut microbiota in human health. It is a holistic approach similar to TCM, but it assesses human health with molecular-marker-based methods; therefore, it can serve as a bridge between TCM and western medical science. This article summarizes the concepts, methodologies, clinical applications, and advantages of “functional metagenomics,” a whole-body systems-biology platform, as a new research strategy for modernization of TCM.

      PubDate: 2012-12-15T09:54:02Z
       
  • Brain Smooth Muscle Axis: A Hypothesis and Its Interrelation with Comorbid
           Depression or Traditional Chinese Medicine Theory of Gan-Shicangxue and
           -Shishuxie
    • Abstract: April 2011
      Publication year: 2011
      Source:World Science and Technology , Volume 13, Issue 2

      Brain-smooth muscle (BSM) axis refers to a bidirectionally influencial and modulatory pathway between the encephalic region and smooth muscle. Via a local cytochrome P450 enzyme and an endogenous active material, stress reaction between the brain and vascular or visceral smooth muscle was modulated, specially implicated depressive comorbidities. Evidence provided by publications and recent experiments of this research group showed that firstly, 40%–50% depression is comorbidity of functional gastrointestinal disorders; a frequent comordibity of functional hypothalamus amenorrhea and depression; depression increases 3- to 6-fold of nocturia than in healthy people; myocardial and cerebral ischemia induce depression. Comorbidity just mentioned especially refers to simultaneous disorders of the brain and vascular or visceral smooth muscle. Secondly, a traditional Chinese medicine formula is as effective as an anti-depressive, prokinetic and vasoactive, which highlights the therapeutic mechanism of modern anti-depressive serotonin and noradrenaline reuptake inhibitors. Absorbed bioactive compounds in hippocampus, intestine and vessel wall were detected after oral administration of the formula and forced swimming rat. Thirdly, both sides of the BSM axis are the same, suggesting the common pathophysiological mechanism. Among the four axes, only “brain”, one side of the axis, is the same and the other sides are different. Fourthly, the pivotal role is that one of the important pathogenetic mechanisms involved in liver visceral manifestation of TCM theory and stress disease is the disorder of the BSM axis. The validation and improvement of the BSM axis hypothesis contribute much to the study of depression, stress diseases and liver visceral manifestation in TCM.

      PubDate: 2012-12-15T09:54:02Z
       
 
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