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  Subjects -> CHEMISTRY (Total: 881 journals)
    - ANALYTICAL CHEMISTRY (54 journals)
    - CHEMISTRY (616 journals)
    - CRYSTALLOGRAPHY (21 journals)
    - ELECTROCHEMISTRY (28 journals)
    - INORGANIC CHEMISTRY (43 journals)
    - ORGANIC CHEMISTRY (48 journals)
    - PHYSICAL CHEMISTRY (71 journals)

CHEMISTRY (616 journals)                  1 2 3 4 | Last

Showing 1 - 200 of 735 Journals sorted alphabetically
2D Materials     Hybrid Journal   (Followers: 14)
Accreditation and Quality Assurance: Journal for Quality, Comparability and Reliability in Chemical Measurement     Hybrid Journal   (Followers: 26)
ACS Catalysis     Hybrid Journal   (Followers: 43)
ACS Chemical Neuroscience     Hybrid Journal   (Followers: 21)
ACS Combinatorial Science     Hybrid Journal   (Followers: 23)
ACS Macro Letters     Hybrid Journal   (Followers: 25)
ACS Medicinal Chemistry Letters     Hybrid Journal   (Followers: 41)
ACS Nano     Hybrid Journal   (Followers: 279)
ACS Photonics     Hybrid Journal   (Followers: 14)
ACS Symposium Series     Full-text available via subscription  
ACS Synthetic Biology     Hybrid Journal   (Followers: 24)
Acta Chemica Iasi     Open Access   (Followers: 5)
Acta Chimica Slovaca     Open Access   (Followers: 2)
Acta Chimica Slovenica     Open Access   (Followers: 1)
Acta Chromatographica     Full-text available via subscription   (Followers: 9)
Acta Facultatis Medicae Naissensis     Open Access  
Acta Metallurgica Sinica (English Letters)     Hybrid Journal   (Followers: 7)
Acta Scientifica Naturalis     Open Access   (Followers: 3)
adhäsion KLEBEN & DICHTEN     Hybrid Journal   (Followers: 7)
Adhesion Adhesives & Sealants     Hybrid Journal   (Followers: 9)
Adsorption Science & Technology     Open Access   (Followers: 6)
Advanced Functional Materials     Hybrid Journal   (Followers: 57)
Advanced Science Focus     Free   (Followers: 5)
Advances in Chemical Engineering and Science     Open Access   (Followers: 67)
Advances in Chemical Science     Open Access   (Followers: 18)
Advances in Chemistry     Open Access   (Followers: 21)
Advances in Colloid and Interface Science     Full-text available via subscription   (Followers: 19)
Advances in Drug Research     Full-text available via subscription   (Followers: 24)
Advances in Environmental Chemistry     Open Access   (Followers: 5)
Advances in Enzyme Research     Open Access   (Followers: 10)
Advances in Fluorine Science     Full-text available via subscription   (Followers: 9)
Advances in Fuel Cells     Full-text available via subscription   (Followers: 16)
Advances in Heterocyclic Chemistry     Full-text available via subscription   (Followers: 11)
Advances in Materials Physics and Chemistry     Open Access   (Followers: 25)
Advances in Nanoparticles     Open Access   (Followers: 15)
Advances in Organometallic Chemistry     Full-text available via subscription   (Followers: 16)
Advances in Polymer Science     Hybrid Journal   (Followers: 44)
Advances in Protein Chemistry     Full-text available via subscription   (Followers: 18)
Advances in Protein Chemistry and Structural Biology     Full-text available via subscription   (Followers: 20)
Advances in Quantum Chemistry     Full-text available via subscription   (Followers: 6)
Advances in Science and Technology     Full-text available via subscription   (Followers: 12)
African Journal of Bacteriology Research     Open Access  
African Journal of Chemical Education     Open Access   (Followers: 3)
African Journal of Pure and Applied Chemistry     Open Access   (Followers: 7)
Agrokémia és Talajtan     Full-text available via subscription   (Followers: 2)
Al-Kimia : Jurnal Penelitian Sains Kimia     Open Access  
Alkaloids: Chemical and Biological Perspectives     Full-text available via subscription   (Followers: 2)
AMB Express     Open Access   (Followers: 1)
Ambix     Hybrid Journal   (Followers: 3)
American Journal of Biochemistry and Biotechnology     Open Access   (Followers: 65)
American Journal of Biochemistry and Molecular Biology     Open Access   (Followers: 20)
American Journal of Chemistry     Open Access   (Followers: 30)
American Journal of Plant Physiology     Open Access   (Followers: 11)
American Mineralogist     Hybrid Journal   (Followers: 15)
Analyst     Full-text available via subscription   (Followers: 38)
Angewandte Chemie     Hybrid Journal   (Followers: 167)
Angewandte Chemie International Edition     Hybrid Journal   (Followers: 244)
Annals of Clinical Chemistry and Laboratory Medicine     Open Access   (Followers: 5)
Annual Reports in Computational Chemistry     Full-text available via subscription   (Followers: 3)
Annual Reports Section A (Inorganic Chemistry)     Full-text available via subscription   (Followers: 4)
Annual Reports Section B (Organic Chemistry)     Full-text available via subscription   (Followers: 9)
Annual Review of Chemical and Biomolecular Engineering     Full-text available via subscription   (Followers: 12)
Annual Review of Food Science and Technology     Full-text available via subscription   (Followers: 13)
Anti-Infective Agents     Hybrid Journal   (Followers: 3)
Antiviral Chemistry and Chemotherapy     Open Access   (Followers: 2)
Applied Organometallic Chemistry     Hybrid Journal   (Followers: 9)
Applied Spectroscopy     Full-text available via subscription   (Followers: 23)
Applied Surface Science     Hybrid Journal   (Followers: 32)
Arabian Journal of Chemistry     Open Access   (Followers: 6)
ARKIVOC     Open Access   (Followers: 1)
Asian Journal of Biochemistry     Open Access   (Followers: 2)
Atomization and Sprays     Full-text available via subscription   (Followers: 4)
Australian Journal of Chemistry     Hybrid Journal   (Followers: 7)
Autophagy     Hybrid Journal   (Followers: 2)
Avances en Quimica     Open Access  
Biochemical Pharmacology     Hybrid Journal   (Followers: 10)
Biochemistry     Hybrid Journal   (Followers: 357)
Biochemistry Insights     Open Access   (Followers: 6)
Biochemistry Research International     Open Access   (Followers: 6)
BioChip Journal     Hybrid Journal  
Bioinorganic Chemistry and Applications     Open Access   (Followers: 10)
Bioinspired Materials     Open Access   (Followers: 5)
Biointerface Research in Applied Chemistry     Open Access   (Followers: 2)
Biointerphases     Open Access   (Followers: 1)
Biology, Medicine, & Natural Product Chemistry     Open Access   (Followers: 2)
Biomacromolecules     Hybrid Journal   (Followers: 21)
Biomass Conversion and Biorefinery     Partially Free   (Followers: 10)
Biomedical Chromatography     Hybrid Journal   (Followers: 7)
Biomolecular NMR Assignments     Hybrid Journal   (Followers: 3)
BioNanoScience     Partially Free   (Followers: 5)
Bioorganic & Medicinal Chemistry     Hybrid Journal   (Followers: 132)
Bioorganic & Medicinal Chemistry Letters     Hybrid Journal   (Followers: 87)
Bioorganic Chemistry     Hybrid Journal   (Followers: 10)
Biopolymers     Hybrid Journal   (Followers: 18)
Biosensors     Open Access   (Followers: 2)
Biotechnic and Histochemistry     Hybrid Journal   (Followers: 2)
Bitácora Digital     Open Access  
Boletin de la Sociedad Chilena de Quimica     Open Access  
Bulletin of the Chemical Society of Ethiopia     Open Access   (Followers: 1)
Bulletin of the Chemical Society of Japan     Full-text available via subscription   (Followers: 24)
Bulletin of the Korean Chemical Society     Hybrid Journal   (Followers: 1)
C - Journal of Carbon Research     Open Access   (Followers: 3)
Cakra Kimia (Indonesian E-Journal of Applied Chemistry)     Open Access  
Canadian Association of Radiologists Journal     Full-text available via subscription   (Followers: 2)
Canadian Journal of Chemistry     Hybrid Journal   (Followers: 10)
Canadian Mineralogist     Full-text available via subscription   (Followers: 6)
Carbohydrate Research     Hybrid Journal   (Followers: 26)
Carbon     Hybrid Journal   (Followers: 70)
Catalysis for Sustainable Energy     Open Access   (Followers: 8)
Catalysis Reviews: Science and Engineering     Hybrid Journal   (Followers: 7)
Catalysis Science and Technology     Free   (Followers: 8)
Catalysis Surveys from Asia     Hybrid Journal   (Followers: 3)
Catalysts     Open Access   (Followers: 10)
Cellulose     Hybrid Journal   (Followers: 7)
Cereal Chemistry     Full-text available via subscription   (Followers: 4)
ChemBioEng Reviews     Full-text available via subscription   (Followers: 1)
ChemCatChem     Hybrid Journal   (Followers: 8)
Chemical and Engineering News     Free   (Followers: 20)
Chemical Bulletin of Kazakh National University     Open Access  
Chemical Communications     Full-text available via subscription   (Followers: 74)
Chemical Engineering Research and Design     Hybrid Journal   (Followers: 26)
Chemical Research in Chinese Universities     Hybrid Journal   (Followers: 3)
Chemical Research in Toxicology     Hybrid Journal   (Followers: 22)
Chemical Reviews     Hybrid Journal   (Followers: 190)
Chemical Science     Open Access   (Followers: 25)
Chemical Technology     Open Access   (Followers: 26)
Chemical Vapor Deposition     Hybrid Journal   (Followers: 5)
Chemie in Unserer Zeit     Hybrid Journal   (Followers: 56)
Chemie-Ingenieur-Technik (Cit)     Hybrid Journal   (Followers: 24)
ChemInform     Hybrid Journal   (Followers: 8)
Chemistry & Biodiversity     Hybrid Journal   (Followers: 7)
Chemistry & Biology     Full-text available via subscription   (Followers: 32)
Chemistry & Industry     Hybrid Journal   (Followers: 7)
Chemistry - A European Journal     Hybrid Journal   (Followers: 159)
Chemistry - An Asian Journal     Hybrid Journal   (Followers: 16)
Chemistry and Materials Research     Open Access   (Followers: 21)
Chemistry Central Journal     Open Access   (Followers: 4)
Chemistry Education Research and Practice     Free   (Followers: 5)
Chemistry in Education     Open Access   (Followers: 9)
Chemistry International     Open Access   (Followers: 2)
Chemistry Letters     Full-text available via subscription   (Followers: 43)
Chemistry of Materials     Hybrid Journal   (Followers: 259)
Chemistry of Natural Compounds     Hybrid Journal   (Followers: 9)
Chemistry World     Full-text available via subscription   (Followers: 19)
Chemistry-Didactics-Ecology-Metrology     Open Access   (Followers: 1)
ChemistryOpen     Open Access   (Followers: 1)
Chemkon - Chemie Konkret, Forum Fuer Unterricht Und Didaktik     Hybrid Journal  
Chemoecology     Hybrid Journal   (Followers: 4)
Chemometrics and Intelligent Laboratory Systems     Hybrid Journal   (Followers: 14)
Chemosensors     Open Access  
ChemPhysChem     Hybrid Journal   (Followers: 12)
ChemPlusChem     Hybrid Journal   (Followers: 2)
ChemTexts     Hybrid Journal  
CHIMIA International Journal for Chemistry     Full-text available via subscription   (Followers: 2)
Chinese Journal of Chemistry     Hybrid Journal   (Followers: 6)
Chinese Journal of Polymer Science     Hybrid Journal   (Followers: 11)
Chromatographia     Hybrid Journal   (Followers: 24)
Chromatography     Open Access   (Followers: 2)
Chromatography Research International     Open Access   (Followers: 6)
Clay Minerals     Full-text available via subscription   (Followers: 10)
Cogent Chemistry     Open Access   (Followers: 1)
Colloid and Interface Science Communications     Open Access  
Colloid and Polymer Science     Hybrid Journal   (Followers: 11)
Colloids and Interfaces     Open Access  
Colloids and Surfaces B: Biointerfaces     Hybrid Journal   (Followers: 6)
Combinatorial Chemistry & High Throughput Screening     Hybrid Journal   (Followers: 4)
Combustion Science and Technology     Hybrid Journal   (Followers: 22)
Comments on Inorganic Chemistry: A Journal of Critical Discussion of the Current Literature     Hybrid Journal   (Followers: 2)
Communications Chemistry     Open Access  
Composite Interfaces     Hybrid Journal   (Followers: 7)
Comprehensive Chemical Kinetics     Full-text available via subscription   (Followers: 1)
Comptes Rendus Chimie     Full-text available via subscription  
Comptes Rendus Physique     Full-text available via subscription   (Followers: 1)
Computational and Theoretical Chemistry     Hybrid Journal   (Followers: 9)
Computational Biology and Chemistry     Hybrid Journal   (Followers: 12)
Computational Chemistry     Open Access   (Followers: 2)
Computers & Chemical Engineering     Hybrid Journal   (Followers: 10)
Coordination Chemistry Reviews     Full-text available via subscription   (Followers: 4)
Copernican Letters     Open Access   (Followers: 1)
Corrosion Series     Full-text available via subscription   (Followers: 6)
Critical Reviews in Biochemistry and Molecular Biology     Hybrid Journal   (Followers: 6)
Croatica Chemica Acta     Open Access  
Crystal Structure Theory and Applications     Open Access   (Followers: 4)
CrystEngComm     Full-text available via subscription   (Followers: 13)
Current Catalysis     Hybrid Journal   (Followers: 2)
Current Chromatography     Hybrid Journal  
Current Green Chemistry     Hybrid Journal  
Current Metabolomics     Hybrid Journal   (Followers: 5)
Current Microwave Chemistry     Hybrid Journal  
Current Opinion in Colloid & Interface Science     Hybrid Journal   (Followers: 9)
Current Opinion in Molecular Therapeutics     Full-text available via subscription   (Followers: 14)
Current Research in Chemistry     Open Access   (Followers: 8)
Current Science     Open Access   (Followers: 69)
Current Trends in Biotechnology and Chemical Research     Open Access   (Followers: 3)
Dalton Transactions     Full-text available via subscription   (Followers: 23)
Detection     Open Access   (Followers: 2)
Developments in Geochemistry     Full-text available via subscription   (Followers: 2)
Diamond and Related Materials     Hybrid Journal   (Followers: 12)
Dislocations in Solids     Full-text available via subscription  
Doklady Chemistry     Hybrid Journal  

        1 2 3 4 | Last

Journal Cover
Acta Chimica Slovenica
Journal Prestige (SJR): 0.274
Citation Impact (citeScore): 1
Number of Followers: 1  

  This is an Open Access Journal Open Access journal
ISSN (Online) 1580-3155
Published by Slovenian Chemical Society Homepage  [1 journal]
  • Dear readers of Acta Chimica Slovenica

    • Authors: Aleksander Pavko
      PubDate: 2018-03-20
      Issue No: Vol. 65, No. 1 (2018)
       
  • Recent Developments and Biological Activities of 2-Aminothiazole
           Derivatives

    • Authors: Mohamed Ezzat Khalifa
      Pages: 1 - 22
      Abstract: Aminothiazole nuclei and their various derivatives have been long used as precursors for the synthesis of biologically active molecules. As a typical heterocyclic amine, 2-aminothiazole is a cornerstone for the synthesis of many compounds, including sulfur drugs, biocides, fungicides, various types of dyes for synthetic fibers and chemical reaction accelerators and as intermediates in the synthesis of antibiotics, where a large number of 2-aminothiazoles have been substituted with different groups for various pharmaceutical purposes, besides their activity as corrosion inhibitors for mild steel protection as well. The synthetic utility of 2-amino-4-substituted-thiazoles, their reactions and biological activities have been surveyed and are presented in this review.
      PubDate: 2018-03-20
      DOI: 10.17344/acsi.2017.3547
      Issue No: Vol. 65, No. 1 (2018)
       
  • Društvene vesti in druge aktivnosti - Society news, announcements,
           activities

    • Authors: Stanislav Oražem
      Pages: 1 - 46
      PubDate: 2018-03-20
      Issue No: Vol. 65, No. 1 (2018)
       
  • B3LYP study of 3-hydroxynaphthalene-2-carboxanilide para-derivatives

    • Authors: Martin Michalík, Peter Poliak, Vladimír Lukeš
      Pages: 23 - 33
      Abstract: A systematic DFT investigation of 3-hydroxy-N-phenylnaphthalene-2-carboxamide and its sixteen para-derivatives is presented. The structural analysis showed that the energetically preferred conformation of all derivatives is practically planar and it is stabilised via intramolecular hydrogen bonds occurring between (C)O×××H(3)O atomic pairs. The quantum chemically evaluated partition coefficients logarithms correlate well with Quantitative Structure–Activity Relationship models as well as with experimentally determined isocratic retention factors logarithm. Theoretical gas-phase proton affinities of amido and hydroxyl group together with selected partial atomic charges reflect the terminal phenyl substitution effect. These quantities are linearly dependent on the in vitro activity against the Mycobacterium Kansasii. Obtained linear correlation functions based on quantum chemically evaluated microscopic properties and selected experimental data may serve as the effective tool in modern drug design for the description of substitution effect.
      PubDate: 2018-03-20
      DOI: 10.17344/acsi.2017.3371
      Issue No: Vol. 65, No. 1 (2018)
       
  • Synthesis and antiproliferative activity of 4H-chromonephenylhydrazones,
           1H-pyrazolecarboxylates and pyrazolylmethanones

    • Authors: China Raju Bhimapaka, Nageswara Rao Rayala, Rajkumar Kommera, Dayakar Cherupally, Ramalinga Murthy Thampunuri, V Kalivendi Shasi
      Pages: 34 - 49
      Abstract: Series of 4H-chromone-based hydrazones 3a–z, pyrazolecarboxylates 5a–x and pyrazolylmethanones 6a–u were prepared and screened for their anti-proliferative activity on A549, HeLa, DU145 and MDAMB 231 cell lines. The hydrazone compound 3s with a chloro substituent on the chromanone moiety and a methoxy group on the phenyl ring displayed promising activity on A549, HeLa and DU145 cell lines. The compound 5p with a bromo substituent on the chromanone moiety and a methyl group on the phenyl ring displayed potent activity on DU145. Furopyrazolecarboxylate 5w having a methyl substituent on the phenyl ring displayed potent activity on HeLa cell line. The pyrazolylmethanone 6e with a fluoro substituent on the phenyl ring and compound 6j having a methyl substituent on the chromanone moiety and a methoxy group on the phenyl ring have shown promising anti-proliferative activity on HeLa cell line.
      PubDate: 2018-03-20
      DOI: 10.17344/acsi.2017.3453
      Issue No: Vol. 65, No. 1 (2018)
       
  • Cis-dioxo-bis [3-methoxy-2,2-dimethylpropanediamine]
           molybdenum/Surfactant-Modified Electrode for Simultaneous sensing of
           Ascorbic Acid and Dopamine

    • Authors: Ali Arjmandi, Hamid Reza Zare-Mehrjardi, Hadi Kargar
      Pages: 50 - 58
      Abstract: In this work, the carbon paste electrode (CPE) was modified using the cis-dioxo-bis[3-methoxy-2,2-dimethylpropanediamine] molybdenum(VI) complex and 1-octanaminium,N,N,N-trioctyl bromide. Using the modified electrode, the best separation of anodic peaks for ascorbic acid and dopamine was obtained in solutions with pH 5.0 and the linear range for ascorbic acid is acquired in the range from 3.0 × 10−6 to 6.0 × 10−3 M and for dopamine from 2.0 × 10−6 to 1.0 × 10−2 M. The limits of detection (S/N = 3) were 4 × 10−7 M and 5 × 10−7 M for dopamine and ascorbic acid, respectively. Surface regeneration and the very easy preparation of the modifiedCPE together with the very good peak resolution and sub-micromolar detection limits designate the prepared carbon paste electrode appropriate for simultaneous voltammetric determination of dopamine and ascorbic acid.
      PubDate: 2018-03-20
      DOI: 10.17344/acsi.2017.3463
      Issue No: Vol. 65, No. 1 (2018)
       
  • Prediction of in vivo Bioavailibility by in vitro Characterization of
           Ethylenediamine Dipropanoic Acid Derivatives with Cytotoxic Activity

    • Authors: Biljana Tubić, Sandra Vladimorov, Bojan Markovic, Tibor Sabo
      Pages: 59 - 64
      Abstract: O,O’-diethyl-(S,S)-ethylenediamine-N,N’-di-2-(3-cyclohexyl)propanoate (DE-EDCP) is novel substance with cytotoxic activity in human leukemic cells. The aim of this study has been to predict in vivo bioavailability of the DE-EDCP and its potential metabolite (S,S)-ethylenediamine-N,N’-di-2-(3-cyclohexyl)propanoic acid (EDCP) by in vitro characterization which includes determination of lipophilicity and passive membrane permeability. There has also been evaluated inter-laboratory reproducibility of the bio-analytical method which was previously developed and validated for non-clinical study of the DE-EDCP and EDCP.
      Distribution coefficient n-octanol/water was 1.68 and 0.03, and apparent permeability coefficient was 4 × 10–4 cm/s and 20 × 10–4 cm/s, for the DE-EDCP and EDCP, respectively.
      Observed results have shown that the DE-EDCP is more lipophilic with better membrane retention, but the EDCP has better pass through the membrane. Also, there has been demonstrated a reproducibility and robustness of the proposed bio-analytical method.
      PubDate: 2018-03-20
      DOI: 10.17344/acsi.2017.3477
      Issue No: Vol. 65, No. 1 (2018)
       
  • Evaluation of Jeffamine® core PAMAM dendrimers for simultaneous removal
           of divalent heavy metal ions from aqueous solutions by polymer assisted
           ultrafiltration

    • Authors: Ali Serol Ertürk, Mustafa Ulvi Gürbüz, Metin Tülü, Abdürrezzak Emin Bozdoğan
      Pages: 65 - 74
      Abstract: Different generations (G3-G4) of amine-terminated Jeffamine® T-403 core poly(amidoamine) PAMAM dendrimers (JCPDs) were used as new macromolecular heavy metal chelating agent templates in polymer assisted ultrafiltration (PAUF) for the investigation of their removal ability for some of the divalent metal ions: Cu, Co, Ni, Cd, and Zn from aqueous solutions under competitive conditions. The effects of pH and generation size of JCPDs were also investigated. Extent of binding (EOB) data can be appropriately expressed by a tetradentate coordination for JCPDs at pH 9 where the maximum removal of metal ions was observed. At pH 9.0, the affinity of both generations towards heavy metal ions was also observed in the decreasing order of Zn(II) > Co(II) > Ni(II) > Cu(II) > Cd(II). Results revealed that the highest total binding capacity was observed for G3-NH2 (262.79 ± 1.62 mg/g) as a little bit higher than that of G4-NH2 (257.27 ± 2.57 mg/g). EOB studies also proved the active contribution of amide groups to metal binding ability of PAMAMs. Both generations were selective towards Cu(II) ions at lower pH 5 and pH 7. From these results, it was concluded that studied JCPDs have the desired technical properties to be used for the removal of toxic metals from wastewaters. 
      PubDate: 2018-03-20
      DOI: 10.17344/acsi.2017.3485
      Issue No: Vol. 65, No. 1 (2018)
       
  • Polythiacalix[4]amides as a novel category of macromolecules; Synthesis,
           Antibacterial evaluation and Investigation on their Spectral and
           Thermophysical Characteristics

    • Authors: Hamed Tashakkorian, Moslem Mansour Lakouraj, Rahimeh Maldar, Zahra Moulana
      Pages: 75 - 85
      Abstract:  Polythiacalix[4]amides as a novel category of polyamides, with high sorption capability towards some environmentally hazardous metal cations, especially Hg2+, have been synthesized via direct polycondensation protocol using a thiacalix[4]arene dicarboxylic acid and commercial diamines. The polyamides were obtained in high yields and possess inherent viscosities in the range of 0.55–0.75 dl/g. The photophysical characteristic was studied by looking for the maximum absorption wavelength of each polymer using UV absorption spectroscopy. Thermogravimetric analysis displayed high thermal stability for these polyamides in range of 337 to 346 °C at the point of 10% weight loss, and their char yields were about 32.9–58.5% at 600 °C. Also, glass transition temperatures were between 157 and 178 °C. To survey on possible sorption capability of these polythiacalixamides, solid–liquid extraction of some toxic transition metal cations, such as Cu2+, Co2+, Cd2+, Pb2+ and Hg2+ from wastewater was performed. Antibacterial evaluation was conducted using Gram positive and Gram negative bacteria strains and some reliable results have been obtained. The results showed some promising features of their ability for being employed as possible ingredients of industrial antibacterial membranes.
      PubDate: 2018-03-20
      DOI: 10.17344/acsi.2017.3604
      Issue No: Vol. 65, No. 1 (2018)
       
  • Spectroscopic, Structural and Density Functional Theory (DFT) Studies of
           two Oxazol-5-one Derivatives

    • Authors: İbrahim Hanif Nazlı, Duygu Barut Celepci, Gül Yakalı, Derya Topkaya, Muhittin Aygün, Serap Alp
      Pages: 86 - 96
      Abstract: In this study, two oxazol-5-one derivatives, C20H20N2O2 (1) and C21H22N2O2 (2), were synthesized by getting condensed p-N,N-diethylaminobenzaldehyde with two presented hippuric acid derivatives and in further studies they were analysed spectrochemically. Molecular and crystal structures of the compounds were determined by single-crystal X-ray diffraction and the results revealed that the molecular packing of the crystal structures were stabilized by weak intra- and intermolecular interactions also with C–O∙∙∙π, C–H∙∙∙π and π∙∙∙π stacking interactions. Computational studies were also performed using DFT method at B3LYP/6-311G(d,p) level of theory. Vibrational modes and chemical shifts were calculated and compared with the experimental data. In addition, frontier molecular orbitals and molecular electrostatic potential surfaces were simulated. The calculated results show that the optimized geometries can well reproduce the crystal structure. Purpose of this study was to survey the effects of the reactants, which were condensed with each other to produce oxazol-5-one, upon the characteristic properties and crystal forms of the final oxazol-5-one.
      PubDate: 2018-03-20
      DOI: 10.17344/acsi.2017.3613
      Issue No: Vol. 65, No. 1 (2018)
       
  • Development of new bexarotene-loaded mesoporous silica systems for topical
           pharmaceutical formulations

    • Authors: Aurelia Vasile, Maria Ignat, Mirela Fernanda Zaltariov, Liviu Sacarescu, Iulian Stoleriu, Dan Draganescu, Mihai Dumitras, Lacramioara Ochiuz
      Pages: 97 - 107
      Abstract: The present study reports the first time use of MCM-41 mesoporous silica as highly efficient carrier for bexarotene - an antineoplastic agent specific for cutaneous T-cell lymphoma treatment. Bexarotene is highly toxic and poor-water soluble, having low bioavailability in the conventional pharmaceutical forms. Comparative uptake of bexarotene on amino-functionalized silica host at various functionalization degrees is discussed in details taking into account all structural features, of matrix as well as properties of the drug molecules. The obtained results proved a successful bexarotene loading on amino-functionalized MCM-41 silica. The bexarotene molecules are adsorbed on the active centers in non-crystalline state proving the major role of the silica amino-functionalization for the drug solubility and bioavailability enhancing. In vitro dissolution tests showed a prolonged release of bexarotene during 12 h, reaching 50% release of loaded active molecules. The prolonged release has been demonstrated to be a result of the presence of aminopropyl groups on the silica pore walls.
      PubDate: 2018-03-20
      DOI: 10.17344/acsi.2017.3641
      Issue No: Vol. 65, No. 1 (2018)
       
  • Synthesis and in vitro bio-activity evaluation of N4-benzyl substituted
           5-chloroisatin-3-thiosemicarbazones as urease and glycation inhibitors

    • Authors: Humayun Pervez, Nazia Khan, Jamshed Iqbal, Sumera Zaib, Muhammad Yaqub, Muhammad Moazzam Naseer
      Pages: 108 - 118
      Abstract: A series of fifteen N4-benzyl substituted 5-chloroisatin-3-thiosemicarbazones 5a–o were synthesized and screened mainly for their antiurease and antiglycation effects. Lemna aequinocitalis growth and Artemia salina assays were carried out to determine their phytotoxicity and cytotoxicity potential. All the compounds proved to be extremely effective urease inhibitors, demonstrating enzyme inhibition much better than the reference inhibitor, thiourea (IC50 values 1.31 ± 0.06 to 3.24 ± 0.15 vs. 22.3 ± 1.12 μM). On the other hand, eight out of fifteen compounds tested, i.e. 5b, 5c, 5h–k, 5m and 5n were found to be potent glycation inhibitors. Of these, five viz. 5c, 5h–j and 5n proved to be exceedingly efficient, displaying glycation inhibition greater than the reference inhibitor, rutin (IC50 values 114.51 ± 1.08 to 229.94 ± 3.40 vs. 294.5 ± 1.5 μM).
      PubDate: 2018-03-20
      DOI: 10.17344/acsi.2017.3649
      Issue No: Vol. 65, No. 1 (2018)
       
  • The effect of adenine adsorption on Zn (II) electroreduction in acetate
           buffer.

    • Authors: Dorota Gugała-Fekner
      Pages: 119 - 126
      Abstract: The paper presents the thermodynamic analysis of adenine adsorption on a mercury electrode in an acetate buffer at pH 3 and pH 4. Adsorption energy and constants were determined using the Frumkin isotherm and the virial isotherm. Stronger adsorption in the buffer at pH 3 was observed in comparison to the buffer at pH 4. Using cyclic voltammetry and Faraday impedance measurement, an inhibitory effect of adenine on the kinetics of Zn(II) ion electro-reduction was observed. 
      PubDate: 2018-03-20
      DOI: 10.17344/acsi.2017.3652
      Issue No: Vol. 65, No. 1 (2018)
       
  • Thermochemical properties and regularities of amides, anilides, and amidic
           acids

    • Authors: Alma Kairlapovna Ryskaliyeva, Murat Ergalievich Baltabayev, Aigul Moldakhmetovna Zhubatova
      Pages: 127 - 130
      Abstract: The thermodynamic properties of carbamide and its alkyl substituted were studied insufficiently. In this article, the enthalpies of combustion of ΔсН of some amides, anilides and amidic acids have been determined experimentally; their standard enthalpies of formation have been calculated. Linear dependences between the average atomic enthalpy of combustion of ΔcH amides and their basicity constants in acidic aqueous solutions of pKBH+have been established; a correlation that relates the enthalpies of combustion of amides and the corresponding amidic acids has been found.
      PubDate: 2018-03-20
      DOI: 10.17344/acsi.2017.3683
      Issue No: Vol. 65, No. 1 (2018)
       
  • Effect of fluorinated ligand on structural, electronic and DNA-binding
           properties of copper paddlewheel complex: synthesis, structure and
           properties

    • Authors: Muhammad Iqbal, Saqib Ali, Muhammad Nawaz Tahir
      Pages: 131 - 137
      Abstract: This paper presents synthesis, structural description and properties of a binuclear paddlewheel copper(II) carboxylate complex with formula [(py)Cu(μ-L)4Cu(py)], where py = pyridine and L =  4-fluorophenylacetate. Structural characteristics, electronic absorption and DNA-binding properties of the synthesized complex have been compared to those of the non-fluorinated analogues (where F is replaced by H, –CH3 and –OCH3) already reported and the modifications successfully ascribed to fluorine. The complex exhibits typical paddlewheel structure and there are two crystallographically independent molecules in the unit cell. The electronic absorption spectrum of complex is also different and the mode and extent of DNA-binding ability of complex are significantly altered owing to the presence of suitably substituted fluorine. The effect of fluorine is clearly manifested in the modified properties of synthesized complex.
      PubDate: 2018-03-20
      DOI: 10.17344/acsi.2017.3702
      Issue No: Vol. 65, No. 1 (2018)
       
  • Preconcentration and determination of trace vanadium(V) in beverages by
           combination of ultrasound assisted-cloud point extraction with
           spectrophotometry

    • Authors: Nuket Kartal Temel, Ramazan Gürkan
      Pages: 138 - 149
      Abstract: A novel ultrasound assisted-cloud point extraction method was developed for preconcentration and determination of V(V) in beverage samples. After complexation by pyrogallol in presence of safranin T at pH 6.0, V(V) ions as ternary complex are extracted into the micellar phase of Triton X-114. The complex was monitored at 533 nm by spectrophotometry. The matrix effect on the recovery of V(V) from the spiked samples at 50 µg L-1 was evaluated. In optimized conditions, the limits of detection and quantification of the method, respectively, was 0.58 and 1.93 µg L-1 in linear range of 2-500 µg L-1 with sensitivity enhancement and preconcentration factors of 47.7 and 40 for preconcentration from 15 mL of sample solution. The recoveries from spiked samples were in range of 93.8-103.2% with a relative standard deviation ranging from 2.6% to 4.1% (25, 100 and 250 µg L-1, n: 5). The accuracy was verified by analysis of two certified samples, and the results were in a good agreement with the certified values. The intra-day and inter-day precision were tested by reproducibility (as 3.3-3.4%) and repeatability (as 3.4-4.1%) analysis for five replicate measurements of V(V) in quality control samples spiked with 5, 10 and 15 µg L-1. Trace V(V) contents of the selected beverage samples by the developed method were successfully determined.
      PubDate: 2018-03-20
      DOI: 10.17344/acsi.2017.3724
      Issue No: Vol. 65, No. 1 (2018)
       
  • Development of a cotton smart textile with medicinal properties using lime
           oil microcapsules

    • Authors: Piyumi B. Wijesirigunawardana, B Gayani K Perera
      Pages: 150 - 159
      Abstract: The present study focused on using microencapsulation technique to develop an antioxidant and antibacterial active smart cotton fabric using encapsulated lime oil (LO). LO microcapsules were prepared via the complex coacervation method using chitosan and gum arabic wall materials. UV-Visible and FTIR spectrometry verified the successful encapsulation of LO. The synthesized LO microcapsules were irregular in shape and differed in size between 15-160 µm according to the optical and SEM images. The loading of the microcapsules was found to be 2943±128 µL/g with a loading efficiency of 82±4%. The antioxidant activity of the LO microcapsules was 1336±17 µg PGE/g (Folin-Ciocalteu assay). Brine shrimp lethality assay indicated that the cytotoxicity of LO was minimized upon microencapsulation. Succinic acid was used as the binder to incorporate the LO microcapsules on to the cotton fabric. The SEM images confirmed the steady attachment of LO microcapsules to the cotton fibres. The cotton fabric containing LO microcapsules displayed significant antibacterial activity against four bacterial species prior to and after subjecting the fabric to wash conditions.
      PubDate: 2018-03-20
      DOI: 10.17344/acsi.2017.3727
      Issue No: Vol. 65, No. 1 (2018)
       
  • Effect of chemical pre-treatments on bioethanol production from Chlorella
           minutissima

    • Authors: Burcu Şerbetçioğlu Sert, Benan İnan, Didem Özçimen
      Pages: 160 - 165
      Abstract: In recent years, algal bioethanol production comes into prominence as a trend towards sustainable development. Due to being sustainable energy source and environmental friendly, bioethanol production from algae is becoming increasingly popular all over the world. However, yield of bioethanol production from algae is lower than first generation feedstock’s currently, and needs to be improved. In order to increase bioethanol yield, pre-treatments should be performed as cell disruption process on algal biomass. For this reason, researchers investigate the most appropriate pre-treatment method and its parameters for high yield bioethanol production from algae. In this study, cultivated Chlorella minutissima was utilized for bioethanol production. Effects of pre-treatment method (dilute acid and alkaline), chemical concentration, pre-treatment temperature and pre-treatment time on bioethanol yield were investigated. It was found that, the highest bioethanol yield was obtained as 18.52% with acid pre-treatment at pre-treatment temperature of 100°C and pre-treatment time of 60 minutes. 
      PubDate: 2018-03-20
      DOI: 10.17344/acsi.2017.3728
      Issue No: Vol. 65, No. 1 (2018)
       
  • A comparative study on a cationic dye removal through homogeneous and
           heterogeneous Fenton oxidation systems

    • Authors: Sima Rahim Pouran, Abolfazl Bayrami, Mohammad Saleh Shafeeyan, Abdul Aziz Abdul Raman, Wan Mohd Ashri Wan Daud
      Pages: 166 - 171
      Abstract: Oxidative treatment of a cationic dye solution, methylene blue, was investigated using magnetite nanoparticles and goethite in heterogeneous Fenton-like reaction, and ferrous ions in homogeneous Fenton-reaction. The aim was to compare the degradation efficiencies of the studied catalysts for decolorization of methylene blue solution as the model organic pollutant. Response surface methodology (RSM) was applied to determine the optimal operational conditions for magnetite/H2O2 and goethite/H2O2 systems. The [H2O2] of 0.2 M, catalyst dosage of 1 g/L, pH  9.0 and reaction time of 5h were chosen by RSM. The pH value of 3.0 was used in the case of   Fe+2/H2O2 system. The experimental results showed that homogeneous Fenton oxidation system was the most effective system under both acidic and neutral conditions but decreased at pH value of 9.0 due to the decrease in available Fe2+ ions in the solution and generation of ferric hydroxide sludge. Fe3O4/H2O2 system represented better removal efficiency than FeO(OH)/H2O2 system that could be attributed to the presence of FeII cations in magnetite structure and its larger surface area.
      PubDate: 2018-03-20
      DOI: 10.17344/acsi.2017.3732
      Issue No: Vol. 65, No. 1 (2018)
       
  • Antioxidative Activity of Methanolic and Water Extracts from the
           Hyperthermophilic Archaeon Aeropyrum pernix K1

    • Authors: Natasa Poklar Ulrih, Mihaela Skrt, Polona Jamnik
      Pages: 172 - 182
      Abstract: The hyperthermophilic archaeon Aeropyrum pernix has adapted to optimal growth under high temperatures in saline environments and under oxidizing conditions. In the present study, we focused on the antioxidative activity of proteins from A. pernix K1. Following high temperature methanol and water extractions of the protein from the biomass of A. pernix K1, the total sulphydryl groups and radical scavenging activities were investigated. The total protein in the methanolic extract was 36% lower and showed 10% fewer sulphydryl groups than that from the water extract. However, the radical scavenging activity of the water extract was four-fold greater than for the methanolic extract. The proteins of both of these extracts were separated by two-dimensional electrophoresis, and selected proteins were identified using mass spectrometry. The majority of these identified proteins were intracellular proteins, such as those involved in oxidative stress responses and osmotic stress responses, and proteins with hydrolase and dehydrogenase activities. These proteins are also common to most organisms, and included putative uncharacterized proteins.
      PubDate: 2018-03-20
      DOI: 10.17344/acsi.2017.3765
      Issue No: Vol. 65, No. 1 (2018)
       
  • Understanding the Inhibition of Mild Steel Corrosion by dianiline Schiff
           bases: a DFT investigation.

    • Authors: Salah Eddine Hachani, Zelikha Necira, Djamel Eddine Mazouzi, Nadia Nebbache
      Pages: 183 - 190
      Abstract: Quantum chemical calculations at DFT/B3LYP level of theory with 6-31G, 6-311G, and 6-311G(d,p) basis sets were done to correlate the inhibition of mild steel corrosion in 1 M H2SO4 by four dianiline Schiff bases namely N,N’-Bis(benzylidene)-4,4’-dianiline (DAA), N,N’-Bis (benzylidene)-4,4’-methylenedianiline (MDAA), N,N’ Bis(benzylidene)-4,4’-sulphonyldianiline (SDAA) and N,N’-Bis(benzylidene)-4,4’-oxydianiline (ODAA) with their electronic and structural properties. Quantum chemical parameters such as the EHOMO, ELUMO, energy gap (∆E), dipole moment (µ), global softness (σ), and global hardness (η) were calculated and discussed to provide valuable explanations for the reactivity and selectivity of the studied inhibitors. The results obtained showed a certain relationship to the experimental inhibition efficiency results earlier reported.
      PubDate: 2018-03-20
      DOI: 10.17344/acsi.2017.3803
      Issue No: Vol. 65, No. 1 (2018)
       
  • Diaquabis(2,2’-dipyridylamine)M(II) terephthalate dihydrates, M(II) =
           Ni, Co: synthesis, crystal structures, thermal and magnetic properties

    • Authors: Lidija Radovanović, Jelena Rogan, Dejan Poleti, Marko V Rodić, Zvonko Jagličić
      Pages: 191 - 198
      Abstract: Two new isostructural M(II) (M = Ni, Co) complexes with 2,2’-dipyridylamine (dipya) and dianion of terephthalic acid (H2tpht), [M(dipya)2(H2O)2](tpht)∙2H2O, have been synthesized by ligand exchange reaction and characterized by single-crystal X-ray diffraction, FTIR spectroscopy, TG/DSC analysis and magnetic measurements. The crystal structures of [M(dipya)2(H2O)2](tpht)∙2H2O consist of discrete complex units in which M(II) adopts deformed octahedral geometries. Two dipya ligands and two water molecules are coordinated to M(II) atom, tpht acts as a counter ion, while additional two water molecules remained uncoordinated. By numerous hydrogen bonds, all structural fragments are connected in three different chains which extend along [100], [010] and [001] directions, giving as a result a complex 3D network. The stabilization of 3D structure is accomplished by non-covalent face to face π-π interactions among pyridyl ring of dipya and benzene ring of tpht from adjacent chains. Towards the applied magnetic field, the both complexes exhibited almost perfect paramagnetic behavior.
      PubDate: 2018-03-20
      DOI: 10.17344/acsi.2017.3813
      Issue No: Vol. 65, No. 1 (2018)
       
  • Synthesis and antibacterial evaluation of some new 1,4-dihydropyridines in
           the presence of Fe3O4@silica sulfonic acid nanocomposite as catalyst

    • Authors: Mohammad Ali Ghasemzadeh, Seyed Mostafa Hasan Nasrollahi, Mohammad Reza Zolfaghari
      Pages: 199 - 207
      Abstract: The synthesis of heterocyclic compounds has been a topic of significant interest because of their broad applications. In this research an effective and eco-friendly approach for the synthesis 1,4-dihydropyridines has been developed via the four-component reactions of arylamines, acetylenedicarboxylates, aromatic aldehydes and ethyl acetoacetate in the presence of Fe3O4@SiO2@OSO3H nanocomposite under solvent-free conditions. The advantages of this method involve the green reaction conditions, simple workup, broad substrates, excellent yields and the reuse of the nanocatalyst. One of the indicators to measure antimicrobial activity is Minimum Inhibitory Concentrations (MIC) that this measure and heterocyclic compounds synthesis inhibition zone diameter was measured on examined bacteria using well diffusion, disc diffusion and determination of antibiotic susceptibility. The results of all three methods suggested the susceptibility of Staphylococcus aureus to synthesized heterocyclic compounds. It can be concluded from the results that these compounds have high antibiotic properties and can be useful in other research and biomedical applications.
      PubDate: 2018-03-20
      DOI: 10.17344/acsi.2017.3820
      Issue No: Vol. 65, No. 1 (2018)
       
  • The Cl functionalized aluminum nitride (AlN) and aluminum phosphide (AlP)
           nanocone sheets as hydrogen selenide (H2Se) sensor: A density functional
           investigation

    • Authors: Seyyed Milad Abrishamifar, Negar Heidari, Razieh Razavi, Milad Janghorban Lariche, Meysam Najafi
      Pages: 208 - 212
      Abstract: The adsorption of H2Se molecule on AlN-NCS and AlP-NCS surfaces were investigated by using of DFT calculations. The potentials of Cl-functionalized AlN-NCS and AlP-NCS for H2Se adsorption were examined. All processes of H2Se-adsorption on considered nanocone sheets were exothermic reactions. The calculated Ead amount of complex H2Se with AlP-NCS was higher than AlN-NCS. The functionalization of considered nanocone sheets with Cl atom increase Ead amount of H2Se. Results reveal that, obtained Ead amounts of considered nanocone sheets have linear relationships with corresponding orbital energy amounts. Finally, the novel nanocone sheets with higher efficiency to adsorption of H2Se can be proposed.
      PubDate: 2018-03-20
      DOI: 10.17344/acsi.2017.3826
      Issue No: Vol. 65, No. 1 (2018)
       
  • Study on the Chelate Formation and the Ion-association of Anionic Chelate
           of Molybdenum(VI) with 3,5-Dinitrocatechol and Monotetrazolium Cation

    • Authors: Kirila Stojnova, Vidka Divarova, Petya Racheva, Kristina Bozhinova, Vanya Lekova
      Pages: 213 - 220
      Abstract: The equilibria of the chelate formation and ion-association in the liquid-liquid extraction system Mo(VI)‒3,5-DNC‒INT‒H2O‒CHCl3 were studied by spectrophotometry. The optimum conditions for the chelate formation and extraction of the ion-associated complex formed between the anionic chelate of Mo(VI)‒3,5-dinitrocatechol (3,5-DNC) and the cation of 2-(4-iodophenyl)-3-(4-nitrophenyl)-5-phenyl-2H-tetrazolium chloride (INT) were established. The validity of Beer’s law was checked and some analytical characteristics were calculated. The effect of various co-existing ions and reagents on the process of complex formation was investigated. The molar ratio of the components in the ternary ion-associated complex Mo(VI)–3,5-DNC–INT was determined by independent methods. The association process in aqueous phase and the extraction equilibria were investigated and quantitatively characterized. The following key constants of the processes were calculated: association constant, distribution constant, extraction constant and recovery factor. Based on this, a reaction scheme, a general formula and a structure of the complex were suggested.
      PubDate: 2018-03-20
      DOI: 10.17344/acsi.2017.3860
      Issue No: Vol. 65, No. 1 (2018)
       
  • Biosorption of 2,4,6-trichlorophenol from aqueous medium using agro-waste:
           Pine (Pinus densiflora Sieb) bark powder

    • Authors: Nadavala Siva Kumar, Mohammad Asif, Mansoor I Al-Hazzaa, Ahmed A. Ibrahim
      Pages: 221 - 230
      Abstract: Most industrial waste discharges are often contaminated with phenolic compounds, which constitute a major source of water pollution owing to their toxicity and low biodegradability. Development of cost-effective treatment of such industrial wastewater is therefore of paramount importance. Towards this end, we explore the efficacy of Pine bark powder (PBP), which is an agricultural solid waste material, as a low-cost biosorbent without any pre-treatment, for the adsorptive removal of 2,4,6-trichlorophenol (2,4,6-TCP) from aqueous media. The PBP was thoroughly characterized and the effect of important adsorption parameters were examined in the present investigation. The batch equilibrium data were analyzed using well-known isotherm models. Freundlich isotherm model provided the best description of the equilibrium biosorption behavior. At 25 ± 1°C, the maximum biosorption capacity (qmax) was 289.09 mg/g, which is higher than most biosorbents reported in the literature while the removal as high as 97% was obtained. Moreover, the biosorption process was fast, attaining equilibrium in less than 120 min of contact. The Elovich model accurately described the kinetics data. In view of high biosorption capacity and fast removal rates, PBP can be used for an efficient and cost-effective treatment of 2,4,6-TCP contaminated wastewater. 
      PubDate: 2018-03-20
      DOI: 10.17344/acsi.2017.3886
      Issue No: Vol. 65, No. 1 (2018)
       
  • Binding Sites of Deprotonated Citric Acid and Ethylenediaminetetraacetic
           Acid in the Chelation With Ba2+, Y3+, and Zr4+ and Their Electronic
           Properties: A Density Functional Theory Study

    • Authors: Nor Ain Fathihah Abdullah, Lee Sin Ang
      Pages: 231 - 238
      Abstract: Density functional calculations were performed on the metal complexes formed during the synthesis of barium zirconate (BZY). This compound has been synthesized previously, but the molecular interactions present during the formation of the ligand–metal complexes are unknown. In this study, calculations were carried out to determine the preferred coordination sites for the metal complexes. The cations Ba2+, Y3+, and Zr4+ were modeled to interact with two deprotonated chelating agents (citric acid [CA] and ethylenediaminetetraacetic acid [EDTA]) at strategic positions. Density functional theory (DFT) at the B3LYP level of theory with basis set 6-31G* and Universal Gaussian Basis Set (UGBS) was used. The relevant geometries, binding energies, and charge distributions of the complexes are reported. It was found that both CA and EDTA can bind the metal cations investigated in this study. Metal cations prefer to form bonds at the electron-rich sites of the chelating agents. Of the three metal cations considered, Zr4+ was found to possess the strongest bonds to deprotonated CA and EDTA, followed by Y3+ and then Ba2+.
      PubDate: 2018-03-20
      DOI: 10.17344/acsi.2017.3890
      Issue No: Vol. 65, No. 1 (2018)
       
  • Investigation of Mechanistic Pathway for Trimethyl borate mediated
           Amidation of (R)-Mandelic Acid for the Synthesis of Mirabegron, an
           Antimuscarinic Agent

    • Authors: Vijayavitthal Thippannachar Mathad, Dattatray G. Deshmukh, Mukund N. Bangal, Mukunda R. Patekar, Vijay J. Medhane
      Pages: 239 - 245
      Abstract: The present work describes investigation of mechanistic pathway for trimethyl borate mediated amidation of (R)-mandelic acid (3) with 4-nitophenylethylamine (2) to provide  (R)-2-hydroxy-N-[2-(4-nitrophenyl)ethyl]-2-phenylacetamide (4) during mirabegron synthesis.Plausible reaction mechanism is proposedby isolating and elucidating the active α-hydroxy ester intermediate 16 from the reaction mass. Trimethylborate mediated approach proved to be selective in providing 4 without disturbing α-hydroxyl group and stereochemistry of chiral center, and is also a greener, economic and production friendly over the reported methods. The developed approach is rapid and efficient for the preparation of4with an overall yield of 85-87% and around 99.0% purity by HPLC at scale.
      PubDate: 2018-03-20
      DOI: 10.17344/acsi.2017.3632
      Issue No: Vol. 65, No. 1 (2018)
       
  • Ultrasound assisted 1,4-diazabicyclo[2.2.2]octaniumdiacetate
           multicomponent synthesis of benzodiazepines: A novel, highly efficient and
           green protocol

    • Authors: Leila Zare Fekri, Shahriar Sarhandi, Esmaila Vessally
      Pages: 246 - 252
      Abstract: A simple and efficient method is presented for the synthesis of benzodiazepines through the multicomponent reaction of o-phenylenediamine, various aldehydes and 5,5-dimethylcyclohexane-1,3-dione (dimedone) in the presence of the acidic bis ionic liquid 1,4-diazabicyclo[2.2.2]octanium diacetate under ultrasound irradiation. The ionic liquid used is recoverable and reusable. This procedure is simple and environmentally friendly, and offers easy work-up, mild conditions and excellent yield in a short reaction time. All of the synthesized compounds were characterized by IR, 1H NMR, mass spectrometry and elemental analysis.
      PubDate: 2018-03-20
      DOI: 10.17344/acsi.2017.3723
      Issue No: Vol. 65, No. 1 (2018)
       
 
 
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