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  Subjects -> CHEMISTRY (Total: 846 journals)
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CHEMISTRY (597 journals)                  1 2 3 | Last

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        1 2 3 | Last

Journal Cover Advances in Heterocyclic Chemistry
  [SJR: 0.497]   [H-I: 31]   [8 followers]  Follow
    
   Full-text available via subscription Subscription journal
   ISSN (Print) 0065-2725
   Published by Elsevier Homepage  [3031 journals]
  • 2-Pyridone Methides (2-Methylene-1,2-dihydropyridines) and Benzo-Fused
           Analogs11Part 1 (Adv. Heterocycl. Chem., 122, 141 (2017)) contains
           Sections 1 and 2 (Introduction and Synthesis, resp.), including Schemes
           1–50 (Formulas 1–303) and Tables 1 and 2. Part 2: Structure,
           Reactivity, and Application
    • Authors: Gunther Fischer
      Abstract: Publication date: Available online 21 April 2017
      Source:Advances in Heterocyclic Chemistry
      Author(s): Gunther Fischer
      One main focus of the review (Part 2) is spectral and physicochemical properties of both N-unsubstituted methides and anhydrobases, including tautomerism and stability. In the sections on chemical reactivity, reactions upon the α-position as well as ring formation and transformation are dominant. Finally, recently published applications are reviewed.

      PubDate: 2017-04-24T20:45:29Z
       
  • Advances in Heterocyclic Chemistry
    • Abstract: Publication date: 2017
      Source:Advances in Heterocyclic Chemistry, Volume 123


      PubDate: 2017-04-03T16:58:05Z
       
  • Editorial Advisory Board
    • Abstract: Publication date: 2017
      Source:Advances in Heterocyclic Chemistry, Volume 123


      PubDate: 2017-04-03T16:58:05Z
       
  • The Literature of Heterocyclic Chemistry, Part XV, 2015
    • Authors: Leonid I. Belen'kii; Yulia B. Evdokimenkova
      Abstract: Publication date: Available online 23 March 2017
      Source:Advances in Heterocyclic Chemistry
      Author(s): Leonid I. Belen'kii, Yulia B. Evdokimenkova
      A systematized survey of reviews and monographs published in 2015 on all aspects of heterocyclic chemistry is given.

      PubDate: 2017-03-27T15:25:19Z
      DOI: 10.1016/bs.aihch.2017.02.001
       
  • Advances in Heterocyclic Chemistry
    • Abstract: Publication date: 2017
      Source:Advances in Heterocyclic Chemistry, Volume 122


      PubDate: 2017-03-20T13:54:36Z
       
  • Editorial Advisory Board
    • Abstract: Publication date: 2017
      Source:Advances in Heterocyclic Chemistry, Volume 122


      PubDate: 2017-03-20T13:54:36Z
       
  • Synthesis and Applications of Thiophene Derivatives as Organic Materials
    • Authors: G. Barbarella; M. Zangoli; F. Di Maria
      Abstract: Publication date: Available online 24 February 2017
      Source:Advances in Heterocyclic Chemistry
      Author(s): G. Barbarella, M. Zangoli, F. Di Maria
      Thiophene-based compounds have acquired increasing importance in materials science and technology, owing to their multiple functional properties, chemical robustness, and versatility. Research studies involving thiophene-based materials are highly interdisciplinary and range from organic electronics, in which the semiconducting properties of these materials are exploited in devices such as thin film field-effect transistors and solar cells, to bioimaging, in which their optical properties are exploited to monitor biological events involving proteins and DNA. Since all fields are concerned with the synthesis of new molecular structures, this chapter also deals with the most recent advances in the synthesis of oligo- and polythiophenes.

      PubDate: 2017-02-24T10:54:36Z
      DOI: 10.1016/bs.aihch.2017.01.001
       
  • Developments in Tetrazole Chemistry (2009–16)
    • Authors: V.A. Ostrovskii; E.A. Popova; R.E. Trifonov
      Abstract: Publication date: Available online 9 February 2017
      Source:Advances in Heterocyclic Chemistry
      Author(s): V.A. Ostrovskii, E.A. Popova, R.E. Trifonov
      This short review compiles the main results of the studies in tetrazole chemistry published in the period 2009–2016. Attention is directed to the structure, reactivity, synthetic problems, functionalization, and also to the application of derivatives of this class of polynitrogen heterocyclic compounds. New conditions are revealed of the tetrazole synthesis underpinned by the use of versatile catalytic systems, ionic liquids, superacids, microwave activation, microreactor techniques, etc. Main trends in the development of the tetrazole chemistry that are helping to focus the efforts of researchers on novel, important, and promising directions of study are considered.

      PubDate: 2017-02-10T13:10:10Z
      DOI: 10.1016/bs.aihch.2016.12.003
       
  • The Synthesis and Chemistry of Azolobenzodiazepines
    • Authors: Hemming
      Abstract: Publication date: Available online 8 February 2017
      Source:Advances in Heterocyclic Chemistry
      Author(s): K. Hemming
      Approaches to the synthesis and applications of the azolobenzodiazepines have been reviewed with a particular focus on the imidazo-, pyrrolo-, pyrazolo-, and triazolo-fused systems. The review covers N-arylation, metal-catalyzed coupling processes, radiolabeled synthesis, multicomponent reactions, and the synthesis of biologically active molecules. Key natural products covered are the fuligocandins, the circumdatins, and other pyrrolobenzodiazepines. The review also covers well-known pharmaceutical substances such as flumazenil, midazolam, SJG-136, and alprazolam.

      PubDate: 2017-02-10T13:10:10Z
       
  • Thiophene-Based Quinomethane Analogs
    • Authors: R.A. Aitken; A.D. Harper
      Abstract: Publication date: Available online 30 January 2017
      Source:Advances in Heterocyclic Chemistry
      Author(s): R.A. Aitken, A.D. Harper
      The chemistry of the stable thiophene-based quinomethane analogs, namely, 3-alkylidenethiophen-2-ones, 2-alkylidenethiophen-3-ones, and 5-alkylidenethiophen-2-ones, is reviewed up to late 2016 with 200 literature references. For each of the three ring systems, the properties, reactivity, synthesis, and applications are systematically covered.

      PubDate: 2017-02-05T12:01:02Z
      DOI: 10.1016/bs.aihch.2016.12.002
       
  • A Synopsis of the Properties and Applications of Heteroaromatic Rings in
           Medicinal Chemistry
    • Authors: N.A. Meanwell
      Abstract: Publication date: Available online 9 January 2017
      Source:Advances in Heterocyclic Chemistry
      Author(s): N.A. Meanwell
      Five- and six-membered heteroaromatic rings and their benzo-fused homologues are well established as important structural elements in drug design and are well represented in approved drugs. The key properties of these heterocycles that are of interest to medicinal chemists include lipophilicity, pK a, aromaticity, ionization potential, H-bond acceptor, and H-bond donor (NH, OH, CH) capability, electron withdrawing effects, dipole values, and bond angles. The judicious and productive application of azoles and azines in drug design requires an understanding of the intrinsic physical chemical properties of the individual heterocycles and how these interact with substituents. In this article, the key properties of azole and azine heterocycles are summarized followed by a synopsis of applications where some of these factors play a role in drug–target interactions and/or potency.

      PubDate: 2017-01-15T19:21:36Z
      DOI: 10.1016/bs.aihch.2016.11.002
       
  • Advances in Heterocyclic Chemistry
    • Abstract: Publication date: 2017
      Source:Advances in Heterocyclic Chemistry, Volume 121


      PubDate: 2017-01-06T17:19:45Z
       
  • Editorial Advisory Board
    • Abstract: Publication date: 2017
      Source:Advances in Heterocyclic Chemistry, Volume 121


      PubDate: 2017-01-06T17:19:45Z
       
  • Synthesis of Heterocycles From Amidrazones
    • Authors: A.A. Aly; M. Ramadan; H.M. Fatthy
      Abstract: Publication date: Available online 29 December 2016
      Source:Advances in Heterocyclic Chemistry
      Author(s): A.A. Aly, M. Ramadan, H.M. Fatthy
      Amidrazones have the structure R1NC(R2)=NNHR3. The ease of forming CN and CN bonds is reflected in their extensive use for the preparation of heterocycles. While the terminal nitrogen atom of the hydrazone moiety in amidrazones (CNNH2) is the most powerful nucleophilic center, the other two nitrogen atoms can also act as nucleophiles and thus complete cyclization processes. In this chapter, we update the utility of amidrazones in heterocycles synthesis.

      PubDate: 2017-01-06T17:19:45Z
      DOI: 10.1016/bs.aihch.2016.11.001
       
  • Diketene as Privileged Synthon in the Syntheses of Heterocycles Part 1:
           Four- and Five-Membered Ring Heterocyclesa
    • Authors: M.M. Heravi; B. Talaei
      Abstract: Publication date: Available online 30 November 2016
      Source:Advances in Heterocyclic Chemistry
      Author(s): M.M. Heravi, B. Talaei
      4-Methyleneoxetan-2-one (Diketene or DK) consists of a four-membered lactone ring adjacent to a methylene function. It can be used as a versatile precursor for the syntheses of wide range of heterocycles including fused and spiral biheterocycles. In this chapter, we try to cover the structural features and reactivity of DK, and underscore its applications as a flexible and useful synthon in the syntheses of four- and five-membered heterocycles as well as a wide variety of fused or spiro heterocycles. This chapter as part 1 is divided in accordance with the ring sizes and subdivided according to types, numbers, and arrangements of heteroatoms.

      PubDate: 2016-12-05T16:58:07Z
      DOI: 10.1016/bs.aihch.2016.10.003
       
  • The Literature of Heterocyclic Chemistry, Part XIV, 2014
    • Authors: Leonid I. Belen'kii; Yu B. Evdokimenkova
      Abstract: Publication date: Available online 21 November 2016
      Source:Advances in Heterocyclic Chemistry
      Author(s): Leonid I. Belen'kii, Yu B. Evdokimenkova
      This bibliographic survey is a sequel to 13 already published in Advances in Heterocyclic Chemistry between 1966 and 2015. It includes monographs and reviews published during 2014 as well as some published earlier, but omitted in Part XIII.

      PubDate: 2016-11-27T15:28:49Z
      DOI: 10.1016/bs.aihch.2016.09.002
       
  • Recent Developments in the Chemistry of 3-Arylisoxazoles and
           3-Aryl-2-isoxazolines
    • Authors: P. Vitale; A. Scilimati
      Abstract: Publication date: Available online 16 November 2016
      Source:Advances in Heterocyclic Chemistry
      Author(s): P. Vitale, A. Scilimati
      3-Arylisoxazoles and 3-aryl-2-isoxazolines are versatile building blocks in organic chemistry. They are components of a wide number of pharmaceutical products and biologically active molecules. This chapter describes developments in the chemistry of these heterocycles, focusing on synthetic methods and reactivity studies published in the years 2005–2016. Particular attention is given to the regioselectivity of synthetic methods and their application to the preparation of pharmacological active compounds.

      PubDate: 2016-11-20T13:13:08Z
      DOI: 10.1016/bs.aihch.2016.10.001
       
  • Synthesis of Piperidines and Dehydropiperidines: Construction of the
           Six-Membered Ring
    • Authors: M.M. Nebe; T. Opatz
      Abstract: Publication date: Available online 16 November 2016
      Source:Advances in Heterocyclic Chemistry
      Author(s): M.M. Nebe, T. Opatz
      The present review focuses on strategies for the construction of piperidines and dehydropiperidines, which have appeared in the literature since 2003/2004 through mid-2016. Synthetic methods involving the construction of the six-membered ring from essentially acyclic starting materials in intra- or intermolecular will be highlighted and discussed. In contrast, methods using only the decoration or modification of previously generated pyridines or piperidines will not be part of this review. The published syntheses will be categorized based on the topology of the bond forming events generating the piperidine core.

      PubDate: 2016-11-20T13:13:08Z
      DOI: 10.1016/bs.aihch.2016.10.002
       
  • Green Syntheses of Heterocycles of Industrial Importance.
           5-Hydroxymethylfurfural as a Platform Chemical
    • Authors: J.G. de Vries
      Abstract: Publication date: Available online 5 October 2016
      Source:Advances in Heterocyclic Chemistry
      Author(s): J.G. de Vries
      The dwindling supply of fossil resources makes it interesting to find renewable resources for our everyday chemicals. 5-Hydroxymethylfurfural (HMF) is easily produced from fructose, although its isolation is not easy in view of its poor stability. More stable equivalents are its ethers or esters or 5-chloromethylfurfural. In this review, we discuss all products that have been made from HMF in the period 2013–2016. Practically in all transformations, catalysis played a major role. One major product obtained by catalyzed oxidation of HMF is 2,5-furandicarboxylic acid, that is touted as a replacement of phthalic acid in polymers. Other compounds that have been made from HMF via hydrogenation and that could find use as monomers are 2,5-furandimethanol, 2,5-tetrahydrofurandimethanol, 1,2,6-hexanetriol, 1,6-hexanediol, 5-hydroxymethyl-2-furanoic acid, and 2,5-diaminomethylfuran. Another interesting oxidation product is 2,5-diformylfuran. Also the nylon intermediates caprolactam, adipic acid, and hexamethylenediamine have been made from HMF. Hydrogenation of HMF in water under slightly acidic conditions gives 1-hydroxy-2,5-hexanedione, which can be cyclized to a cyclopentenone derivative. Acyloin condensation gives the dimeric product, which can be hydrogenated to a diesel fuel substitute. Carbon–carbon bond formation has been performed both by Diels–Alder reaction on the furan as well as by condensation on the aldehyde and/or alcohol functionalities. Hydrogenolysis of the side chains leads to formation of 2,5-dimethylfuran, which has been proposed as fuel additive. Oxidation of HMF to butenolides, maleic acid, and anhydride as well as succinic acid has been reported. Various other transformations are also described. It is expected that HMF will be increasingly important in the direct future and, indeed, commercial production of HMF and some of its derivatives has already commenced.

      PubDate: 2016-10-10T16:49:39Z
      DOI: 10.1016/bs.aihch.2016.09.001
       
  • 2-Pyridone Methides (2-Methylene-1,2-dihydropyridines) and Benzo-Fused
           Analogs—Part 1: Synthesis
    • Authors: Fischer
      Abstract: Publication date: Available online 30 August 2016
      Source:Advances in Heterocyclic Chemistry
      Author(s): G. Fischer
      The review (Part 1) deals with the synthesis of 2-pyridone methides and benzo-fused analogs. Methides that are unsubstituted at the nitrogen atom are mainly synthesized from the corresponding pyridine bases by reactions at o- or α-positions, from N-oxides or by ring formation or transformation. N-Substituted so-called anhydrobases mostly originate from quaternary salts either by deprotonation or by reactions at o- or α-positions.

      PubDate: 2016-09-02T19:45:40Z
       
  • The Evolving Landscape of Heterocycles in Drugs and Drug Candidates
    • Authors: Tony Y. Zhang
      Abstract: Publication date: Available online 8 August 2016
      Source:Advances in Heterocyclic Chemistry
      Author(s): Tony Y. Zhang
      Substructure analysis of approved drugs and drug candidates in clinical trials was performed to illustrate the evolving roles of heterocycles in pharmaceutical research. The increasing representation of biaryls and heteroaromatics is noted and attributed predominantly to their better accessibility brought upon by advances in metal catalyzed cross-coupling and hetero-coupling reactions. Possible future focus of academic research is proposed for improving structural diversity and probability of success for drug research, and enhancing the impact of heterocyclic chemistry to the development of new medicines.

      PubDate: 2016-08-13T10:07:30Z
      DOI: 10.1016/bs.aihch.2016.05.001
       
  • Advances in Heterocyclic chemistry
    • Abstract: Publication date: 2016
      Source:Advances in Heterocyclic Chemistry, Volume 120


      PubDate: 2016-07-23T03:39:00Z
       
  • Editorial Advisory Board
    • Abstract: Publication date: 2016
      Source:Advances in Heterocyclic Chemistry, Volume 120


      PubDate: 2016-07-23T03:39:00Z
       
  • Heterocyclic Building Blocks for Organic Semiconductors
    • Authors: Xikang Zhao; Saadia T. Chaudhry; Jianguo Mei
      Abstract: Publication date: Available online 29 June 2016
      Source:Advances in Heterocyclic Chemistry
      Author(s): Xikang Zhao, Saadia T. Chaudhry, Jianguo Mei
      Organic semiconductors are an important class of functional materials. Numerous molecular and polymeric organic semiconductors have been developed for their great potentials in next generation flexible and printed electronics. In this chapter, the authors review some of the most popular heterocyclic building blocks and their chemistry. These building blocks are organized based on the heteroatom(s) that are present in their structures, including sulfur-, nitrogen-, silicon-, phosphorus-, and boron-containing heterocycles.

      PubDate: 2016-07-11T21:23:33Z
      DOI: 10.1016/bs.aihch.2016.04.009
       
  • Thiazole and Isothiazole Ring–Containing Compounds in Crop
           Protection
    • Authors: Peter Maienfisch; Andrew J.F. Edmunds
      Abstract: Publication date: Available online 21 June 2016
      Source:Advances in Heterocyclic Chemistry
      Author(s): Peter Maienfisch, Andrew J.F. Edmunds
      Organic compounds containing five-membered aromatic heterocyclic rings play an important role in life science. Among them thiazole and isothiazole heterocycles are present in many pharmaceutical drugs and crop protection compounds and have sparked over past years an enormous interest on these scaffolds. In agrochemicals these moieties are found in 11 commercial products as well as in two development compounds. A thiazole moiety is present in nine currently marketed agrochemicals, namely the insecticides thiamethoxam and clothianidin; the fungicides thiabendazole, thifluzamide, ethaboxam, benthiavalicarb, and oxathiapiprolin; the nematicide fluensulfone; as well as in the development compound dicloromezotiaz. One compound, the fungicide isotianil, contains an isothiazole ring; two compounds a benzothiazole ring, namely the herbicides methabenzthiazuron and mefenacet; and one compound, the former nematicide development compound benclothiaz, contains a benzisothiazole ring. Interestingly thiazole and isothiazole heterocycles are much less frequently found in agrochemicals than pyridine and pyrazole despite their bioisosteric relationship, which may indicate that these heterocycles have still not been explored to their full scope in crop protection lead discovery and optimization. Detailed information on the discovery, synthesis, and the structure–activity relationships of thiazole- and isothiazole-containing agrochemicals is provided in this review.

      PubDate: 2016-07-11T21:23:33Z
      DOI: 10.1016/bs.aihch.2016.04.010
       
  • Saturated Heterocycles with Applications in Medicinal Chemistry
    • Authors: Charles M. Marson
      Abstract: Publication date: Available online 17 May 2016
      Source:Advances in Heterocyclic Chemistry
      Author(s): Charles M. Marson
      In recent years, the advantages of incorporating saturated heterocyclic rings in therapeutic agents have become increasingly apparent, as compared to using only aromatic and heteroaromatic ring systems. In particular, saturated heterocyclic ring systems play a central role in medicinal chemistry; frequent advantages include improved aqueous solubility and lower toxicity of metabolites, as well as the potential for greater diversity partly through stereoisomerism. This review illustrates examples of saturated heterocycles with relevance to medicinal chemistry as published in the years 2013–2015. The three main categories discussed are small and medium ring systems containing one heteroatom, spiroheterocyclic ring systems, and heterobicyclo systems.

      PubDate: 2016-05-19T18:38:13Z
      DOI: 10.1016/bs.aihch.2016.03.004
       
  • Palladium-Catalyzed Carbonylative Synthesis of Heterocycles
    • Authors: Jian-Bo Feng; Xiao-Feng Wu
      Abstract: Publication date: Available online 17 May 2016
      Source:Advances in Heterocyclic Chemistry
      Author(s): Jian-Bo Feng, Xiao-Feng Wu
      Palladium-catalyzed carbonylative coupling reactions have been a powerful method in organic synthesis. The importance and significance have been described abundantly. Moreover, with the rapid development of palladium-catalyzed coupling reactions, various elegant methodologies for palladium-catalyzed carbonylative synthesis of heterocycles have been developed. In this chapter, the main achievements from 2013 to the middle 2015 are discussed.

      PubDate: 2016-05-19T18:38:13Z
      DOI: 10.1016/bs.aihch.2016.04.003
       
  • Heterogeneously Catalyzed Synthesis of Heterocyclic Compounds
    • Authors: Colin H. McAteer; Ramiah Murugan; Yarlagadda V. Subba Rao
      Abstract: Publication date: Available online 17 May 2016
      Source:Advances in Heterocyclic Chemistry
      Author(s): Colin H. McAteer, Ramiah Murugan, Yarlagadda V. Subba Rao
      This chapter covers the synthesis of heterocyclic compounds using heterogeneous catalysts from the perspective of practicing industrial chemists. Before discussing the synthesis of various heterocycles using heterogeneous catalysts a brief discussion on catalyst choice and classification of reaction chemistry is provided. Next, the synthesis of commercially important heterocycles from acyclic precursors is provided starting with the three-membered aziridines and epoxides. For the four-membered heterocycles, propiolactone synthesis is discussed followed by the five-membered pyrroles, furans, and thiophenes. Within the five-membered ring category of heterocycles, the benz-fused pyrrole, indole and rings with more than one heteroatom such as pyrazoles, imidazoles, thiazoles, oxa- and thio-diazoles synthesis are also discussed. Similar to the five-membered ring heterocycles, the six-membered heterocycle syntheses discussed are pyridines, picolines, quinolines, acridines, pyrimidines, pyrazines, triazines, coumarins, etc. Finally a small section on process and economics consideration is provided along with final comments.

      PubDate: 2016-05-19T18:38:13Z
      DOI: 10.1016/bs.aihch.2016.03.003
       
  • Nitrogen-Rich Azoles as High Density Energy Materials: Reviewing the
           Energetic Footprints of Heterocycles
    • Authors: Ping Yin; Jean'ne M. Shreeve
      Abstract: Publication date: Available online 17 May 2016
      Source:Advances in Heterocyclic Chemistry
      Author(s): Ping Yin, Jean'ne M. Shreeve
      In this contribution, recent developments of azole-based high energy density materials are reviewed. A variety of azoles, e.g., pyrazole, imidazole, triazole, and tetrazole, were used as nitrogen-rich backbones and were functionalized with explosophores. The synthetic methods, experimental properties, and theoretical calculations are discussed leading to panoramas of these promising energetic materials.

      PubDate: 2016-05-19T18:38:13Z
      DOI: 10.1016/bs.aihch.2016.04.004
       
  • SF5-Substituted Aromatic Heterocycles
    • Authors: Oleksandr S. Kanishchev; William R. Dolbier
      Pages: 1 - 42
      Abstract: Publication date: Available online 17 May 2016
      Source:Advances in Heterocyclic Chemistry
      Author(s): Oleksandr S. Kanishchev, William R. Dolbier
      The review contains a comprehensive analysis of all examples related to the synthesis, reactions, and biological assay of SF5-substituted aromatic heterocycles that were available in scientific literature and patents through the end of 2015. The review is divided into three major sections with each representing one of the three known methods for the synthesis of SF5-substituted heterocycles—starting from SF5-substituted benzenes, from SF5Cl (SF5Br) or by oxidative fluorination of heterocyclic sulfur substituent.

      PubDate: 2016-05-19T18:38:13Z
      DOI: 10.1016/bs.aihch.2016.03.008
       
  • Synthesis of Aromatic Heterocycles Using Ring-Closing Metathesis
    • Authors: Harish K. Potukuchi; Ignacio Colomer; Timothy J. Donohoe
      Pages: 43 - 65
      Abstract: Publication date: Available online 19 May 2016
      Source:Advances in Heterocyclic Chemistry
      Author(s): Harish K. Potukuchi, Ignacio Colomer, Timothy J. Donohoe
      Ring-closing metathesis (RCM) is one of the most widely applied methods for the synthesis of a range of ring systems. Highlighting seminal examples from literature, this chapter, on the synthesis of aromatic heterocycles using RCM, discusses contributions from the Donohoe group. This chapter is divided into various sections based on the type of aromatic heterocycle synthesized. Application of the developed methodologies toward the synthesis of natural products is also elaborated.

      PubDate: 2016-05-19T18:38:13Z
      DOI: 10.1016/bs.aihch.2016.04.006
       
 
 
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