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CHEMISTRY (593 journals)                  1 2 3 | Last

Showing 1 - 200 of 735 Journals sorted alphabetically
2D Materials     Hybrid Journal   (Followers: 8)
Accreditation and Quality Assurance: Journal for Quality, Comparability and Reliability in Chemical Measurement     Hybrid Journal   (Followers: 26)
ACS Catalysis     Full-text available via subscription   (Followers: 34)
ACS Chemical Neuroscience     Full-text available via subscription   (Followers: 18)
ACS Combinatorial Science     Full-text available via subscription   (Followers: 23)
ACS Macro Letters     Full-text available via subscription   (Followers: 23)
ACS Medicinal Chemistry Letters     Full-text available via subscription   (Followers: 39)
ACS Nano     Full-text available via subscription   (Followers: 233)
ACS Photonics     Full-text available via subscription   (Followers: 11)
ACS Synthetic Biology     Full-text available via subscription   (Followers: 21)
Acta Chemica Iasi     Open Access   (Followers: 2)
Acta Chimica Sinica     Full-text available via subscription   (Followers: 1)
Acta Chimica Slovaca     Open Access   (Followers: 1)
Acta Chromatographica     Full-text available via subscription   (Followers: 9)
Acta Facultatis Medicae Naissensis     Open Access  
Acta Metallurgica Sinica (English Letters)     Hybrid Journal   (Followers: 5)
Acta Scientifica Naturalis     Open Access   (Followers: 2)
adhäsion KLEBEN & DICHTEN     Hybrid Journal   (Followers: 5)
Adhesion Adhesives & Sealants     Hybrid Journal   (Followers: 7)
Adsorption Science & Technology     Full-text available via subscription   (Followers: 5)
Advanced Functional Materials     Hybrid Journal   (Followers: 50)
Advanced Science Focus     Free   (Followers: 3)
Advances in Chemical Engineering and Science     Open Access   (Followers: 55)
Advances in Chemical Science     Open Access   (Followers: 13)
Advances in Chemistry     Open Access   (Followers: 14)
Advances in Colloid and Interface Science     Full-text available via subscription   (Followers: 18)
Advances in Drug Research     Full-text available via subscription   (Followers: 22)
Advances in Enzyme Research     Open Access   (Followers: 9)
Advances in Fuel Cells     Full-text available via subscription   (Followers: 15)
Advances in Heterocyclic Chemistry     Full-text available via subscription   (Followers: 8)
Advances in Materials Physics and Chemistry     Open Access   (Followers: 19)
Advances in Nanoparticles     Open Access   (Followers: 15)
Advances in Organometallic Chemistry     Full-text available via subscription   (Followers: 15)
Advances in Polymer Science     Hybrid Journal   (Followers: 41)
Advances in Protein Chemistry     Full-text available via subscription   (Followers: 18)
Advances in Protein Chemistry and Structural Biology     Full-text available via subscription   (Followers: 19)
Advances in Quantum Chemistry     Full-text available via subscription   (Followers: 5)
Advances in Science and Technology     Full-text available via subscription   (Followers: 12)
African Journal of Bacteriology Research     Open Access  
African Journal of Chemical Education     Open Access   (Followers: 2)
African Journal of Pure and Applied Chemistry     Open Access   (Followers: 7)
Agrokémia és Talajtan     Full-text available via subscription   (Followers: 2)
Alkaloids: Chemical and Biological Perspectives     Full-text available via subscription   (Followers: 3)
AMB Express     Open Access   (Followers: 1)
Ambix     Hybrid Journal   (Followers: 3)
American Journal of Biochemistry and Biotechnology     Open Access   (Followers: 68)
American Journal of Biochemistry and Molecular Biology     Open Access   (Followers: 14)
American Journal of Chemistry     Open Access   (Followers: 26)
American Journal of Plant Physiology     Open Access   (Followers: 14)
American Mineralogist     Hybrid Journal   (Followers: 14)
Analyst     Full-text available via subscription   (Followers: 40)
Angewandte Chemie     Hybrid Journal   (Followers: 219)
Angewandte Chemie International Edition     Hybrid Journal   (Followers: 212)
Annales UMCS, Chemia     Open Access   (Followers: 1)
Annals of Clinical Chemistry and Laboratory Medicine     Open Access   (Followers: 2)
Annual Reports in Computational Chemistry     Full-text available via subscription   (Followers: 3)
Annual Reports Section A (Inorganic Chemistry)     Full-text available via subscription   (Followers: 4)
Annual Reports Section B (Organic Chemistry)     Full-text available via subscription   (Followers: 8)
Annual Review of Chemical and Biomolecular Engineering     Full-text available via subscription   (Followers: 12)
Annual Review of Food Science and Technology     Full-text available via subscription   (Followers: 15)
Anti-Infective Agents     Hybrid Journal   (Followers: 3)
Antiviral Chemistry and Chemotherapy     Hybrid Journal  
Applied Organometallic Chemistry     Hybrid Journal   (Followers: 7)
Applied Spectroscopy     Full-text available via subscription   (Followers: 23)
Applied Surface Science     Hybrid Journal   (Followers: 28)
Arabian Journal of Chemistry     Open Access   (Followers: 6)
ARKIVOC     Open Access   (Followers: 2)
Asian Journal of Biochemistry     Open Access   (Followers: 1)
Atomization and Sprays     Full-text available via subscription   (Followers: 4)
Australian Journal of Chemistry     Hybrid Journal   (Followers: 7)
Autophagy     Hybrid Journal   (Followers: 2)
Avances en Quimica     Open Access   (Followers: 1)
Biochemical Pharmacology     Hybrid Journal   (Followers: 10)
Biochemistry     Full-text available via subscription   (Followers: 293)
Biochemistry Insights     Open Access   (Followers: 6)
Biochemistry Research International     Open Access   (Followers: 6)
BioChip Journal     Hybrid Journal  
Bioinorganic Chemistry and Applications     Open Access   (Followers: 9)
Bioinspired Materials     Open Access   (Followers: 5)
Biointerface Research in Applied Chemistry     Open Access   (Followers: 2)
Biointerphases     Open Access   (Followers: 1)
Biology, Medicine, & Natural Product Chemistry     Open Access   (Followers: 1)
Biomacromolecules     Full-text available via subscription   (Followers: 19)
Biomass Conversion and Biorefinery     Partially Free   (Followers: 10)
Biomedical Chromatography     Hybrid Journal   (Followers: 6)
Biomolecular NMR Assignments     Hybrid Journal   (Followers: 3)
BioNanoScience     Partially Free   (Followers: 4)
Bioorganic & Medicinal Chemistry     Hybrid Journal   (Followers: 119)
Bioorganic & Medicinal Chemistry Letters     Hybrid Journal   (Followers: 96)
Bioorganic Chemistry     Hybrid Journal   (Followers: 10)
Biopolymers     Hybrid Journal   (Followers: 18)
Biosensors     Open Access   (Followers: 2)
Biotechnic and Histochemistry     Hybrid Journal   (Followers: 1)
Bitácora Digital     Open Access  
Boletin de la Sociedad Chilena de Quimica     Open Access  
Bulletin of the Chemical Society of Ethiopia     Open Access   (Followers: 2)
Bulletin of the Chemical Society of Japan     Full-text available via subscription   (Followers: 24)
Bulletin of the Korean Chemical Society     Hybrid Journal   (Followers: 1)
C - Journal of Carbon Research     Open Access   (Followers: 3)
Cakra Kimia (Indonesian E-Journal of Applied Chemistry)     Open Access  
Canadian Association of Radiologists Journal     Full-text available via subscription   (Followers: 3)
Canadian Journal of Chemistry     Hybrid Journal   (Followers: 10)
Canadian Mineralogist     Full-text available via subscription   (Followers: 3)
Carbohydrate Research     Hybrid Journal   (Followers: 26)
Carbon     Hybrid Journal   (Followers: 66)
Catalysis for Sustainable Energy     Open Access   (Followers: 7)
Catalysis Reviews: Science and Engineering     Hybrid Journal   (Followers: 8)
Catalysis Science and Technology     Free   (Followers: 6)
Catalysis Surveys from Asia     Hybrid Journal   (Followers: 3)
Catalysts     Open Access   (Followers: 8)
Cellulose     Hybrid Journal   (Followers: 7)
Cereal Chemistry     Full-text available via subscription   (Followers: 4)
ChemBioEng Reviews     Full-text available via subscription   (Followers: 1)
ChemCatChem     Hybrid Journal   (Followers: 8)
Chemical and Engineering News     Free   (Followers: 13)
Chemical Bulletin of Kazakh National University     Open Access  
Chemical Communications     Full-text available via subscription   (Followers: 71)
Chemical Engineering Research and Design     Hybrid Journal   (Followers: 23)
Chemical Research in Chinese Universities     Hybrid Journal   (Followers: 3)
Chemical Research in Toxicology     Full-text available via subscription   (Followers: 19)
Chemical Reviews     Full-text available via subscription   (Followers: 174)
Chemical Science     Open Access   (Followers: 22)
Chemical Technology     Open Access   (Followers: 16)
Chemical Vapor Deposition     Hybrid Journal   (Followers: 5)
Chemical Week     Full-text available via subscription   (Followers: 8)
Chemie in Unserer Zeit     Hybrid Journal   (Followers: 57)
Chemie-Ingenieur-Technik (Cit)     Hybrid Journal   (Followers: 26)
ChemInform     Hybrid Journal   (Followers: 8)
Chemistry & Biodiversity     Hybrid Journal   (Followers: 6)
Chemistry & Biology     Full-text available via subscription   (Followers: 30)
Chemistry & Industry     Hybrid Journal   (Followers: 5)
Chemistry - A European Journal     Hybrid Journal   (Followers: 142)
Chemistry - An Asian Journal     Hybrid Journal   (Followers: 15)
Chemistry and Materials Research     Open Access   (Followers: 18)
Chemistry Central Journal     Open Access   (Followers: 4)
Chemistry Education Research and Practice     Free   (Followers: 5)
Chemistry in Education     Open Access   (Followers: 9)
Chemistry International     Hybrid Journal   (Followers: 2)
Chemistry Letters     Full-text available via subscription   (Followers: 45)
Chemistry of Materials     Full-text available via subscription   (Followers: 257)
Chemistry of Natural Compounds     Hybrid Journal   (Followers: 9)
Chemistry World     Full-text available via subscription   (Followers: 22)
Chemistry-Didactics-Ecology-Metrology     Open Access   (Followers: 1)
ChemistryOpen     Open Access   (Followers: 2)
Chemkon - Chemie Konkret, Forum Fuer Unterricht Und Didaktik     Hybrid Journal  
Chemoecology     Hybrid Journal   (Followers: 3)
Chemometrics and Intelligent Laboratory Systems     Hybrid Journal   (Followers: 15)
Chemosensors     Open Access  
ChemPhysChem     Hybrid Journal   (Followers: 9)
ChemPlusChem     Hybrid Journal   (Followers: 2)
ChemTexts     Hybrid Journal  
CHIMIA International Journal for Chemistry     Full-text available via subscription   (Followers: 2)
Chinese Journal of Chemistry     Hybrid Journal   (Followers: 6)
Chinese Journal of Polymer Science     Hybrid Journal   (Followers: 10)
Chromatographia     Hybrid Journal   (Followers: 24)
Clay Minerals     Full-text available via subscription   (Followers: 10)
Cogent Chemistry     Open Access  
Colloid and Interface Science Communications     Open Access  
Colloid and Polymer Science     Hybrid Journal   (Followers: 10)
Colloids and Surfaces B: Biointerfaces     Hybrid Journal   (Followers: 7)
Combinatorial Chemistry & High Throughput Screening     Hybrid Journal   (Followers: 4)
Combustion Science and Technology     Hybrid Journal   (Followers: 18)
Comments on Inorganic Chemistry: A Journal of Critical Discussion of the Current Literature     Hybrid Journal   (Followers: 2)
Composite Interfaces     Hybrid Journal   (Followers: 6)
Comprehensive Chemical Kinetics     Full-text available via subscription   (Followers: 2)
Comptes Rendus Chimie     Full-text available via subscription  
Comptes Rendus Physique     Full-text available via subscription   (Followers: 1)
Computational and Theoretical Chemistry     Hybrid Journal   (Followers: 9)
Computational Biology and Chemistry     Hybrid Journal   (Followers: 12)
Computational Chemistry     Open Access   (Followers: 2)
Computers & Chemical Engineering     Hybrid Journal   (Followers: 9)
Coordination Chemistry Reviews     Full-text available via subscription   (Followers: 2)
Copernican Letters     Open Access   (Followers: 1)
Critical Reviews in Biochemistry and Molecular Biology     Hybrid Journal   (Followers: 5)
Crystal Structure Theory and Applications     Open Access   (Followers: 3)
CrystEngComm     Full-text available via subscription   (Followers: 12)
Current Catalysis     Hybrid Journal   (Followers: 2)
Current Metabolomics     Hybrid Journal   (Followers: 5)
Current Opinion in Colloid & Interface Science     Hybrid Journal   (Followers: 9)
Current Research in Chemistry     Open Access   (Followers: 8)
Current Science     Open Access   (Followers: 58)
Dalton Transactions     Full-text available via subscription   (Followers: 22)
Detection     Open Access   (Followers: 2)
Developments in Geochemistry     Full-text available via subscription   (Followers: 2)
Diamond and Related Materials     Hybrid Journal   (Followers: 12)
Dislocations in Solids     Full-text available via subscription  
Doklady Chemistry     Hybrid Journal  
Drying Technology: An International Journal     Hybrid Journal   (Followers: 4)
Eclética Química     Open Access   (Followers: 1)
Ecological Chemistry and Engineering S     Open Access   (Followers: 4)
Ecotoxicology and Environmental Contamination     Open Access  
Educación Química     Open Access   (Followers: 1)
Education for Chemical Engineers     Hybrid Journal   (Followers: 5)
EJNMMI Radiopharmacy and Chemistry     Open Access  
Elements     Full-text available via subscription   (Followers: 2)
Environmental Chemistry     Hybrid Journal   (Followers: 8)
Environmental Chemistry Letters     Hybrid Journal   (Followers: 4)
Environmental Science & Technology Letters     Full-text available via subscription   (Followers: 5)
Environmental Science : Nano     Partially Free   (Followers: 1)
Environmental Toxicology & Chemistry     Hybrid Journal   (Followers: 17)

        1 2 3 | Last

Journal Cover BioNanoScience
  [SJR: 0.428]   [H-I: 10]   [4 followers]  Follow
   Partially Free Journal Partially Free Journal
   ISSN (Print) 2191-1630 - ISSN (Online) 2191-1649
   Published by Springer-Verlag Homepage  [2353 journals]
  • A Novel Silver Coating for Antigen-Microarray Preparation Suitable for
           Application on Antibody Recognition
    • Authors: Salvatore Petralia; Giorgio Ventimiglia; Stefano Ceschia; Maurizio Gasparin; Roberto Verardo
      Pages: 449 - 455
      Abstract: Abstract The present paper reports the development of a novel silver nanoparticles-derivatized polystyrene substrate useful for for protein microarray application. The silvered coating was prepared by a novel photochemical method. Various coatings were tested and characterized by means of chemical-physical methods. It was demonstrated that these methods are useful for the preparation of protein microarray for the analysis of human antibody by sandwich methods of fluorescence immunoassay (Alexa labeled). Comparative studies were carried out with different printing buffers and various surface derivatization to find the optimal conditions for antigen immobilization. Therein described assay, the human myeloperoxidase antigen (MPO) was quantitative detected directly from human serum. The cross-reactivity was here evaluated by reaction with recombinant human tissue transglutaminase antigen (htTG), a linearity response from 20 to 2000 ng/μl was investigated by human IgG probes. The data indicate an increase of both signal-to-noise ratio value and reproducibility for the silver nanoparticle coating respect the value obtained for the polystyrene commercial slides.
      PubDate: 2017-09-01
      DOI: 10.1007/s12668-017-0398-y
      Issue No: Vol. 7, No. 3 (2017)
  • A Facile Method of Preparation of Polymer-Stabilized Perfluorocarbon
           Nanoparticles with Enhanced Contrast for Molecular Magnetic Resonance
    • Authors: Lev L. Gervits; Andrey V. Shibaev; Mikhail V. Gulyaev; Vyacheslav S. Molchanov; Nikolai V. Anisimov; Yury A. Pirogov; Alexei R. Khokhlov; Olga E. Philippova
      Pages: 456 - 463
      Abstract: Abstract We present a new efficient method of incorporation of gadolinium chelates into polymeric shell surrounding liquid nanoparticles of perfluorotributylamine, which does not degrade the particles stability. The payload reaches ca. 105 Gd ions per nanoparticle giving large local concentration of contrast agent. The relaxivity of Gd-loaded nanoparticles estimated by magnetic resonance imaging at 7 T magnetic field is as high as 105–106 mM−1 s−1. These nanoparticles are promising for dual-mode imaging simultaneously on two nuclei 1H and 19F, thus enhancing the quality of visualization.
      PubDate: 2017-09-01
      DOI: 10.1007/s12668-017-0400-8
      Issue No: Vol. 7, No. 3 (2017)
  • Modeling of Blood Flow Through a Bifurcated Artery Using Nanofluid
    • Authors: D. Srinivasacharya; G. Madhava Rao
      Pages: 464 - 474
      Abstract: Abstract A mathematical model for blood flow through a bifurcated artery with mild stenosis in its parent artery is presented by taking blood as a copper suspended nanofluid with water as base fluid. The boundary of bifurcated artery is converted into a well-organized boundary using suitable transformations. The numerical solutions for temperature profiles, flow rate, impedance, and shear stress are found by using the finite difference method. The influence of admissible parameters on physical quantities on both sides of the apex is discussed graphically. It has been noticed that flow rate and impedance have been changed suddenly with the pertinent parameters on both sides of the apex. This occurs because of the backflow of the streaming blood at the onset of the lateral junction and secondary flow near the apex. All these observations on blood flow through bifurcated artery are of medical interest.
      PubDate: 2017-09-01
      DOI: 10.1007/s12668-017-0402-6
      Issue No: Vol. 7, No. 3 (2017)
  • A Novel High Linear CMOS Fully Integrated PA for the Design of Zigbee
    • Authors: H. Thabet; S. Meillère; M. Masmoudi; J.-L. Seguin; H. Barthelemy; K. Aguir
      Pages: 475 - 484
      Abstract: Abstract This paper describes a 863–870-MHz transmitter for wireless sensor applications. The fully integrated designed circuit is based on AMS 0.35-μm CMOS standard technology. The transmitter presented is composed by four stages: quadrature voltage-controlled ring oscillator (QVCO) controlled by a voltage (V CTRL), two passive switch mixers, two combiners (a substractor and an adder), and a novel high linear power amplifier (PA). Combiners and the PA has the distinction of being based on CMOS inverter circuit. The post-layout simulation of the fully differential transmitter, at the desired oscillation frequency and under a supply voltage of 3.3 V, shows that proposed circuits satisfy specifications desired especially the output power level and PA linearity.
      PubDate: 2017-09-01
      DOI: 10.1007/s12668-017-0405-3
      Issue No: Vol. 7, No. 3 (2017)
  • Magnetic Beads Compatibility as DNA Hybridization Labels in Integrated
           Thermal-Magnetic Biosensor
    • Authors: Salvatore Petralia; Maria Eloisa Castagna; Angela Beninato; Valentina Sinatra; Salvatore Baglio; Sabrina Conoci
      Pages: 485 - 491
      Abstract: Abstract In this paper, we investigated the applicative using of thermal-magnetic biosensor (TMAGS) for DNA detection. TMAGS is a planar device composed by a primary microcoil able to generate a magnetic field which induces a voltage equal and opposite on two secondary coils. The presence of magnetic material on one of the two secondary coils causes a variation of induced magnetic field especially in the area where the magnetic material is located. In particular, here, we studied the compatibility of two different typologies of beads (MNB1 and MNB2) as magnetic labels towards DNA hybridization process in TMAGS device. These two types of beads differ in size (1 and 0.1 μm), magnetic material location (core or shell), and chemical surface proprieties (electrostatic or covalent bonds possible). In particular, in the first part of the work, we investigate the response of the TMAGS architectures versus the two-bead topology and we found MNB1 exhibits a better output voltage signal (on average 30% higher than the voltage signal of MNB2). On the contrary, when they are employed as magnetic label in a real DNA hybridization process in TMAGS device, only MNB2 typology gives positive results. We ascertain that both the size of the bead and the nature of the chemical bond between the magnetic label (beads) and the DNA target, that must be a covalent bond, play a key role on the success of hybridization reaction. Therefore, a compromise between magnetic content (bead size) and nature of bead-target chemical bond must be selected for the future employment of these devices in molecular detection.
      PubDate: 2017-09-01
      DOI: 10.1007/s12668-017-0410-6
      Issue No: Vol. 7, No. 3 (2017)
  • Influence of Molecular Characteristics of Chitosan on Properties of In
           situ Formed Scaffolds
    • Authors: T. E. Grigoriev; Y. D. Zagoskin; S. I. Belousov; A. V. Vasilyev; T. B. Bukharova; G. E. Leonov; E. V. Galitsyna; D. V. Goldshtein; S. N. Chvalun; A. A. Kulakov; M. A. Paltsev
      Pages: 492 - 495
      Abstract: Abstract Effects of molecular weight and degree of deacetylation of chitosan on the properties of chitosan/beta-glycerophosphate situ forming gel were investigated. Storage modulus grows with a decrease of the degree of deacetylation of the chitosan whereas molecular weight has not so strong influence on storage modulus. Higher molecular weight chitosans showed lower cytotoxicity.
      PubDate: 2017-09-01
      DOI: 10.1007/s12668-017-0411-5
      Issue No: Vol. 7, No. 3 (2017)
  • Influence of Thermal Separation of Oleic Acid on the Properties of Quantum
           Dots Solutions and Optoelectronic of Their Langmuir Monolayers
    • Authors: Ammar J Al-Alwani; A. S. Chumakov; I. A. Gorbachev; Nikolai Kuznetsov; A. A. Kletsov; E. G. Glukhovskoy
      Pages: 496 - 500
      Abstract: Abstract This article presents a description of a method of oleic acid separation from quantum dot (QD) solution. The oleic acid is a good stabilizer for CdSe/CdS/ZnS QD solution. QDs are an interesting material for fabricating the optoelectronic devices. The main disadvantage in QDs’ presence is an excess unbounded surfactant of the oleic acid. Oleic acid ligands have some defect on the morphology and modify the electronic structure of thin film QDs. One of the methods that allow to remove this excess surfactant is a separation by using high-density polyethylene (HDPE) membrane with thermal treatment. The thermal treatment has an effect on the separation of surfactants and the period of process. The changing in the number of surfactants in QD solution during various conditions is recorded by Langmuir-Blodgett (LB) technique. The QD monolayers are deposited on solid substrate by using Langmuir-Schaefer method. The changing in morphology is studied by atomic force microscopy (AFM). Photoluminescence (PL) spectra and photoconductivity properties of QDs are studied. The change in the surface pressure during separation was recorded. The conductivity enhancement and shifting of PL spectra were observed. It is related to decreasing number of an excess surfactant and changing structure of QDs’ outer shell.
      PubDate: 2017-09-01
      DOI: 10.1007/s12668-017-0412-4
      Issue No: Vol. 7, No. 3 (2017)
  • Bioactivity of Ag Nanoclusters Capped with Crude Protein Extracts from the
           Sea Anemone Heteractis magnifica
    • Authors: Rafael A. Espiritu; Princess Bea Clyde R. Rebustillo
      Pages: 501 - 507
      Abstract: Abstract Novel protein-based nanomaterials are gaining much interest in recent years due in large part to their more environment-friendly preparation schemes coupled with promising biological activities. Although nanoparticles synthesized from protein sources are not new, various researches are still continuously investigating other potential templates and sources of new protein-based materials. In this study, Ag nanoclusters capped with crude protein extracts from the sea anemone Heteractis magnifica (H. magnifica) were prepared via one-pot, green synthesis, and subjected to preliminary biological activity testing. Fourier transform infrared spectroscopy (FTIR) analysis indicated successful capping of the nanoclusters, consistent with previous reports utilizing similar synthetic protocols, while scanning electron microscopy (SEM) revealed the presence of more aggregates on the surface of the prepared nanoclusters. Formation of the nanoclusters resulted in a slight to moderate antibacterial, but not antifungal, activity, although the material also showed a concentration-dependent hemolytic action. In contrast, the unmodified extract did not show any antimicrobial action while being more hemolytic as well. These results demonstrate the potential of these protein-capped Ag nanoclusters as antibacterial agents, although its unwanted hemolytic side effect will have to be reduced for it to have any therapeutic potential.
      PubDate: 2017-09-01
      DOI: 10.1007/s12668-017-0414-2
      Issue No: Vol. 7, No. 3 (2017)
  • Chitosan-Gellan Gum Bipolymeric Nanohydrogels—a Potential Nanocarrier
           for the Delivery of Epigallocatechin Gallate
    • Authors: Shakti Dahiya; Ruma Rani; Sandeep Kumar; Dinesh Dhingra; Neeraj Dilbaghi
      Pages: 508 - 520
      Abstract: Abstract Encapsulation of a hydrophilic drug into a polymeric matrix always remains a challenging process due to poor loading and retention capacity. A novel nanoscale drug delivery system, i.e., nanohydrogels, has been developed by virtue of combination of ionotropic gelation and polyelectrolyte complexation technique for the delivery of a popular hydrophilic drug, (−)-epigallocatechin gallate (EGCG). EGCG is one of the popular bioactive compounds present in green tea. Chitosan and gellan gum were used as cationic and anionic polysaccharides, and magnesium chloride was used as cross-linking agent for the synthesis of nanohydrogels in the present study. Effects of polymers and cross-linker were optimized using a three-level two-factor central composite Design-Expert Software. The final optimized EGCG-loaded nanohydrogels were evaluated for particle size, encapsulation efficiency, stability, and morphological and drug release studies. Comparative antioxidant and antibacterial potentials of EGCG-loaded nanohydrogels and EGCG were examined. EGCG-loaded nanohydrogels show more antioxidant and antibacterial potential at the same dose level as compared to the pure EGCG. Therefore, advanced nanoscale drug delivery systems with a reduced dose level and significant effectiveness over the conventional systems may increase their use in the near future for the betterment of healthcare applications.
      PubDate: 2017-09-01
      DOI: 10.1007/s12668-017-0416-0
      Issue No: Vol. 7, No. 3 (2017)
  • Efficient, Green and One Pot Synthesis of Sodium Acetate Functionalized
    • Authors: Munish Kumar; Rajni Bala; Vijay Singh Gondil; D. V. S. Jain; Sanjay Chhibber; Rohit K Sharma; Nishima Wangoo
      Pages: 521 - 529
      Abstract: Abstract Silver nanoparticles have received a lot of attention in the past decade as efficient antimicrobial agents. However, their use as food preservatives is still limited. Keeping this in mind, in this study, we report the synthesis of silver nanoparticles by a cost effective and green approach using sodium acetate (a well-known low cost food preservative) as reducing/capping agent. The synthesized silver nanoparticles were thoroughly characterized using UV-Visible absorption spectroscopy, dynamic light scattering, zeta potential, fourier transform infrared (FT-IR) spectroscopy, proton nuclear magnetic resonance (1H NMR) spectroscopy, and transmission electron microscopy (TEM). The morphology of the synthesized silver nanoparticles was found to be spherical in nature and the size was approximately 20 ± 2 nm as confirmed through TEM images. Further, in order to explore the potential application of sodium acetate capped silver nanoparticles as food preservatives, the antimicrobial activity of these nanoparticles was tested on different bacteria like Escherichia coli, methicillin-resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosa, and Klebsiella pneumoniae. The results show that the synthesized nanoparticles are highly active on the listed bacterial strains even at very low concentrations, confirming their potential as efficient food preservatives.
      PubDate: 2017-09-01
      DOI: 10.1007/s12668-017-0417-z
      Issue No: Vol. 7, No. 3 (2017)
  • Biosynthesis of Zinc Oxide Nanoparticles Using Plant Extracts of Aloe vera
           and Hibiscus sabdariffa : Phytochemical, Antibacterial, Antioxidant and
           Anti-proliferative Studies
    • Authors: D. Mahendiran; G. Subash; D. Arumai Selvan; Dilaveez Rehana; R. Senthil Kumar; A. Kalilur Rahiman
      Pages: 530 - 545
      Abstract: Abstract The zinc oxide (ZnO) nanoparticles were successfully synthesized by using aqueous extracts of Aloe vera gel/leaf and Hibiscus sabdariffa leaf, and characterized by FT IR, UV-Vis, XRD, SEM, and EDX techniques. For comparison purposes, ZnO nanoparticles was also synthesized by chemical method. Phytochemical screening of the A. vera gel and leaf and H. sabdariffa leaf extracts showed the presence of alkaloids, carbohydrates, flavonoids, gums and mucilages, saponins, phenolic compounds, tannins, and terpenoids. FT IR spectra showed the presence of functional groups and protein as the stabilizing agent surrounding the ZnO nanoparticles. UV-Vis spectra of ZnO nanoparticles exhibit the characteristic absorption band in the range of 344–360 nm, which can be assigned to the intrinsic bandgap absorption of ZnO due to the electron transitions from the valence band to the conduction band. Powder XRD patterns confirmed the hexagonal wurtzite structure. Further, the SEM analysis also indicates the hexagonal rod shape structure of the ZnO nanoparticles. EDX spectra confirmed the chemical composition of the ZnO nanoparticles synthesized by both biological and chemical methods. In vitro antibacterial activity of ZnO nanoparticles synthesized by both biological and chemical methods were performed on three Gram (−ve) (Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa) and one Gram (+ve) (Staphylococcus aureus) bacteria, in which the ZnO nanoparticles obtained by biological method showed excellent bactericidal activity over that obtained by chemical method. All the ZnO nanoparticles showed promising antioxidant activity determined by five different methods such as 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS); 2,2′-diphenyl-1-picrylhydrazyl (DPPH); hydrogen peroxide (H2O2); superoxide radical scavenging; and hydroxyl radical scavenging assays. In vitro cytotoxicity of the ZnO nanoparticles were tested against three cancerous cell lines such as human breast adenocarcinoma (MCF-7), cervical (HeLa) and epithelioma (Hep-2), and one normal human dermal fibroblasts (NHDF) cell lines by MTT assay. Apoptosis induction was further confirmed by flow cytometry and cell cycle arrest. The ZnO nanoparticles obtained by biological method display remarkable cytotoxicity against the MCF-7 cell line, and found to be more potent than the widely used drug cisplatin.
      PubDate: 2017-09-01
      DOI: 10.1007/s12668-017-0418-y
      Issue No: Vol. 7, No. 3 (2017)
  • Soxhlet Extraction of Neem Pigment to Synthesize Iron Oxide Nanoparticles
           and Its Catalytic and Adsorption Activity for Methylene Blue Removal
    • Authors: Priyabrata Pal; Salma S. Syed; Fawzi Banat
      Pages: 546 - 553
      Abstract: Abstract Green synthesis of iron oxide nanoparticles is gaining importance recently due to its cost-effectivity and ecofriendly treatment technique. The aim of the present study is to concentrate neem (Azadirachta indica) leaf pigment using Soxhlet extraction and to synthesize iron oxide nanoparticles and to check its efficacy in degrading methylene blue dye in aqueous solution. Characterization of the synthesized iron oxide nanoparticles is carried out using X-ray diffraction (XRD), Fourier Transform Infrared (FTIR) spectroscopy, Scanning Electron Microscopy (SEM) equipped with Energy Dispersive X-ray (EDX) spectroscopy, Transmission Electron Microscopy (TEM), and Vibrating Sample Magnetometer (VSM) analysis. The characterization results confirm the formation of iron oxide (α-Fe2O3) nanoparticles. Obtained nanoparticles were evaluated for degradation and adsorption of methylene blue (MB) dye. It enhanced the degradation of methylene blue dye to 95.93% in the presence of 0.1 (N) sodium hydroxide solution (82.69% in the absence of α-Fe2O3). The maximum uptake capacity of MB was increased from 64.1 to 99.0 mg/g using native calcium alginate hydrogel and calcium alginate impregnated with produced iron oxide nanoparticle composite hydrogel, respectively. Thus, extraction of pigment from neem leaves and synthesized iron oxide nanoparticles showed satisfactory results.
      PubDate: 2017-09-01
      DOI: 10.1007/s12668-017-0420-4
      Issue No: Vol. 7, No. 3 (2017)
  • Erratum to: A Review on Mycosynthesis, Mechanism, and Characterization of
           Silver and Gold Nanoparticles
    • Authors: Kangkana Banerjee; V. Ravishankar Rai
      PubDate: 2017-09-11
      DOI: 10.1007/s12668-017-0448-5
  • Production and Characterization of Antimicrobial Electrospun Nanofibers
           Containing Polyurethane, Zirconium Oxide and Zeolite
    • Authors: Mehmet Onur Aydogdu; Alexandra Elena Oprea; Roxana Trusca; Adrian Vasile Surdu; Anton Ficai; Alina Maria Holban; Florin Iordache; Andrei Viorel Paduraru; Diana Georgiana Filip; Esra Altun; Nazmi Ekren; Faik Nuzhet Oktar; Oguzhan Gunduz
      Abstract: Abstract In this study, electrospinning technique has been utilized to prepare composite nanofiber mats of polyurethane (PU)/zirconium dioxide (ZrO2) and PU/zeolite, consisted by antimicrobial properties. Tensile strength measurement test was performed for the mechanical analysis of the nanofibers. Scanning electron microscopy (SEM) were performed for displaying the morphological features of the fiber structure. XRD tests were performed for revealing the chemical structure. Antimicrobial tests were also performed to display antimicrobial effects of the produced materials. In vitro test was also performed to determine cytotoxicity and biocompatibility. The present PU/ZrO2 and PU/zeolite composite nanofibers resulted with improved mechanical properties and good antimicrobial properties against either their pure forms or other studies. Cell proliferation and viability also increased significantly with increase in zeolite and ZrO2 ratio. It is concluded that this composition provides a novel alternative as an antimicrobial material which can be suitable as a wound dressing or a coating material for various healthcare engineering applications.
      PubDate: 2017-09-07
      DOI: 10.1007/s12668-017-0443-x
  • PEG-Coated Superparamagnetic Dysprosium-Doped Fe 3 O 4 Nanoparticles for
           Potential MRI Imaging
    • Authors: Timur Sh. Atabaev
      Abstract: Abstract In recent years, superparamagnetic nanoparticles (NPs) have attracted considerable attention due to their high potential for biomedical applications. This study describes a facile preparation method of superparamagnetic polyethylene glycol (PEG)-coated dysprosium-doped Fe3O4 NPs for potential magnetic resonance imaging (MRI) applications. The structure, morphology, and magnetic properties of the dysprosium-doped Fe3O4 NPs were analyzed by X-ray diffraction (XRD), transmission electron microscopy (TEM), and quantum design vibrating sample magnetometer (QD-VSM), respectively. The MRI imaging ability of the dysprosium-doped Fe3O4 NPs was assessed using a 1.5-T small animal MRI scanner. In addition, pilot studies were performed to examine the toxicity of the PEG-coated dysprosium-doped Fe3O4 NPs. The obtained results suggested that prepared NPs could be used for potential T2-weighted MRI imaging.
      PubDate: 2017-08-30
      DOI: 10.1007/s12668-017-0447-6
  • Hyperfibrinogenemia and Increased Stiffness of Plasma Clots in the Active
           Systemic Lupus Erythematosus
    • Authors: L. D. Zubairova; R. M. Nabiullina; M. A. Shakurova; T. B. Sibgatullin; A. N. Maksudova; R. I. Litvinov
      Abstract: Abstract Systemic lupus erythematosus (SLE) is an autoimmune disease associated with an increased risk of thrombosis. We hypothesized that inflammation-associated hyperfibrinogenemia can contribute to the prothrombotic phenotype of fibrin clots by changing their mechanical properties. Twenty-eight SLE patients were categorized based on their disease activity scores (SLEDAI) into the groups with inactive (SLEDAI < 4, n = 14) and active (SLEDAI > 4, n = 14) forms of the disease. Clots from individual platelet-free plasma samples were probed using shear rheometry and viscoelastic properties of the fibrin gels were determined as the storage (G′) and loss (G″) moduli. A significant increase of G′ was revealed in the clots from the plasma of active SLE patients over inactive SLE, which correlated with elevated fibrinogen levels. Clots from the plasma of inactive SLE patients had the elasticity and fibrinogen levels indistinguishable from those in control plasma from healthy subjects. Thus, inflammatory hyperfibrinogenemia in the active SLE form makes fibrin clots stiffer which has been previously shown to be associated with a higher incidence of thrombotic disorders.
      PubDate: 2017-08-28
      DOI: 10.1007/s12668-017-0445-8
  • Target Cells for Stem Cell Factor in the Adult Islets of Langerhans,
           Simultaneously Synthesizing Glucagon and Insulin
    • Authors: Maxim Kaligin; Dina Andreeva; Angelina Titova; Marina Titova; Anisa Gumerova; Andrey Kiyasov
      Abstract: Abstract C-kit—a stem cell receptor, or CD117, is one of the markers of human pancreatic endocrinocyte progenitor cells. Its important role in the proliferation and differentiation of pancreatic endocrine cells during human prenatal development has already been proven. However, the presence and role of c-kit-positive cells in adult pancreatic islets remains unclear. The purpose of our study was to establish the presence of c-kit-positive cells in the adult pancreatic islets and to assess whether they retain the ability to proliferate during a lifetime. We studied pancreatic autopsies of adults aged 50 to 70 years, which were obtained in pathology departments of Kazan hospitals. Samples of the pancreas were embedded in paraffin using standard techniques. Paraffin sections of the pancreas were stained immunohistochemically with commercial antibodies against c-kit, insulin, glucagon, and Ki-67. Few c-kit-positive cells simultaneously secreting insulin or glucagon were detected in all samples studied. These data suggest that such cells are in a state of differentiation into endocrinocytes, but no proliferation of c-kit-positive cells was observed.
      PubDate: 2017-08-21
      DOI: 10.1007/s12668-017-0444-9
  • Generation and Characterization of Cell-Derived Microvesicles from HUVECs
    • Authors: Solène Cherre; Mathilde Granberg; Ole Østergaard; Niels H. H. Heegaard; Noemi Rozlosnik
      Abstract: Abstract Microvesicles (MVs) are of great interest for the biomedical field as novel diagnostics biomarkers. MV research, however, is still impaired by the lack of standardization of the analysis methods. In this study, our goals were to develop a method for the reproducible generation of an MV population from cell culture, to compare the sizing of MVs by atomic force microscopy (AFM) and nanoparticle tracking analysis (NTA) and to develop an MV array allowing the sizing and phenotyping of MVs simultaneously with the AFM as a read-out. MVs were isolated from apoptotic human umbilical vein endothelial cells (HUVECs) and had a mean size of 115 nm as measured by AFM and of 197 nm as measured by NTA. MVs isolated from apoptotic and control HUVECs could not be distinguished by their size (p > 0.05). HUVECs and their released MVs shared the same phenotype (positive for endothelial markers CD31 and CD146 and negative for platelet marker CD42b). Our method generated MVs with a concentration which was reproducible within a range of 20%. This is a relevant model system for medical applications. The size of the MVs was larger as measured using NTA compared to that using AFM. The MV array was efficient to characterize the surface markers of MVs and has the potential to identify the cellular origins of MVs in patient samples.
      PubDate: 2017-08-15
      DOI: 10.1007/s12668-017-0438-7
  • Cloning and Expression of a Metalloprotease Gene from Morganella morganii
           Strain ZM
    • Authors: Leyla Minnullina; Margarita Sharipova; Ayslu Mardanova
      Abstract: Abstract Morganella morganii is an opportunistic pathogen which causes a wide range of clinical infections. It is well known that metalloproteases synthesized by pathogenic microorganisms play an important role as virulence factors. In this work, we have conducted bioinformatic analysis, sequencing, and cloning of the gene encoding a putative metalloprotease from M. morganii (AN CP004345.1, MU9_1718). We detected that the amino acid sequence of putative metalloprotease from M. morganii strain KT has 37% identity to actin-specific metalloproteases grimelysin and protealysin from Serratia grimesii and Serratia proteamaculans, respectively. Based on ORF MU9_1718 sequence, we have identified a metalloprotease gene in the genome of clinical isolate M. morganii ZM. The gene was cloned under the control of arabinose promoter into pBAD/Myc-His expression vector, and Escherichia coli DH5α cells were subsequently transformed by this vector. We also provide data indicating that the metalloprotease was overexpressed in E. coli DH5α cells as a 35 kDa protein.
      PubDate: 2017-08-14
      DOI: 10.1007/s12668-017-0439-6
  • Structural Alterations of Monocytes in Systemic Lupus Erythematosus
    • Authors: I. A. Andrianova; A. A. Ponomareva; R. I. Litvinov
      Abstract: Abstract Systemic lupus erythematosus (SLE) is an autoimmune disease in which the immune system mistakenly attacks multiple organs and tissues of the body. To elucidate the involvement of blood cells in the pathogenesis of SLE, we used transmission electron microscopy to study ultrastructure of monocytes isolated from the blood of SLE patients. We found that in the SLE patients, a substantial fraction of monocytes had abnormal morphology that corresponded to the structural signs of either necrosis or apoptosis. The number of altered monocytes in the SLE patients was significantly higher than in healthy subjects and related directly with the level of anti-dsDNA autoantibodies in the blood. Our results suggest that monocytes are involved in the pathogenesis of SLE and undergo adverse necrotic and/or apoptotic changes, likely induced by autoantibodies.
      PubDate: 2017-08-12
      DOI: 10.1007/s12668-017-0441-z
School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
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