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CHEMISTRY (601 journals)                  1 2 3 4 | Last

Showing 1 - 200 of 735 Journals sorted alphabetically
2D Materials     Hybrid Journal   (Followers: 11)
Accreditation and Quality Assurance: Journal for Quality, Comparability and Reliability in Chemical Measurement     Hybrid Journal   (Followers: 26)
ACS Catalysis     Full-text available via subscription   (Followers: 39)
ACS Chemical Neuroscience     Full-text available via subscription   (Followers: 19)
ACS Combinatorial Science     Full-text available via subscription   (Followers: 23)
ACS Macro Letters     Full-text available via subscription   (Followers: 24)
ACS Medicinal Chemistry Letters     Full-text available via subscription   (Followers: 40)
ACS Nano     Full-text available via subscription   (Followers: 258)
ACS Photonics     Full-text available via subscription   (Followers: 12)
ACS Synthetic Biology     Full-text available via subscription   (Followers: 24)
Acta Chemica Iasi     Open Access   (Followers: 2)
Acta Chimica Sinica     Full-text available via subscription   (Followers: 1)
Acta Chimica Slovaca     Open Access   (Followers: 1)
Acta Chimica Slovenica     Open Access  
Acta Chromatographica     Full-text available via subscription   (Followers: 9)
Acta Facultatis Medicae Naissensis     Open Access  
Acta Metallurgica Sinica (English Letters)     Hybrid Journal   (Followers: 5)
Acta Scientifica Naturalis     Open Access   (Followers: 2)
adhäsion KLEBEN & DICHTEN     Hybrid Journal   (Followers: 5)
Adhesion Adhesives & Sealants     Hybrid Journal   (Followers: 8)
Adsorption Science & Technology     Full-text available via subscription   (Followers: 5)
Advanced Functional Materials     Hybrid Journal   (Followers: 51)
Advanced Science Focus     Free   (Followers: 3)
Advances in Chemical Engineering and Science     Open Access   (Followers: 58)
Advances in Chemical Science     Open Access   (Followers: 13)
Advances in Chemistry     Open Access   (Followers: 15)
Advances in Colloid and Interface Science     Full-text available via subscription   (Followers: 18)
Advances in Drug Research     Full-text available via subscription   (Followers: 23)
Advances in Enzyme Research     Open Access   (Followers: 9)
Advances in Fuel Cells     Full-text available via subscription   (Followers: 16)
Advances in Heterocyclic Chemistry     Full-text available via subscription   (Followers: 9)
Advances in Materials Physics and Chemistry     Open Access   (Followers: 23)
Advances in Nanoparticles     Open Access   (Followers: 14)
Advances in Organometallic Chemistry     Full-text available via subscription   (Followers: 15)
Advances in Polymer Science     Hybrid Journal   (Followers: 41)
Advances in Protein Chemistry     Full-text available via subscription   (Followers: 18)
Advances in Protein Chemistry and Structural Biology     Full-text available via subscription   (Followers: 20)
Advances in Quantum Chemistry     Full-text available via subscription   (Followers: 6)
Advances in Science and Technology     Full-text available via subscription   (Followers: 12)
African Journal of Bacteriology Research     Open Access  
African Journal of Chemical Education     Open Access   (Followers: 2)
African Journal of Pure and Applied Chemistry     Open Access   (Followers: 7)
Agrokémia és Talajtan     Full-text available via subscription   (Followers: 2)
Al-Kimia : Jurnal Penelitian Sains Kimia     Open Access  
Alkaloids: Chemical and Biological Perspectives     Full-text available via subscription   (Followers: 3)
AMB Express     Open Access   (Followers: 1)
Ambix     Hybrid Journal   (Followers: 3)
American Journal of Biochemistry and Biotechnology     Open Access   (Followers: 68)
American Journal of Biochemistry and Molecular Biology     Open Access   (Followers: 15)
American Journal of Chemistry     Open Access   (Followers: 28)
American Journal of Plant Physiology     Open Access   (Followers: 14)
American Mineralogist     Hybrid Journal   (Followers: 15)
Analyst     Full-text available via subscription   (Followers: 39)
Angewandte Chemie     Hybrid Journal   (Followers: 168)
Angewandte Chemie International Edition     Hybrid Journal   (Followers: 237)
Annales UMCS, Chemia     Open Access   (Followers: 1)
Annals of Clinical Chemistry and Laboratory Medicine     Open Access   (Followers: 4)
Annual Reports in Computational Chemistry     Full-text available via subscription   (Followers: 3)
Annual Reports Section A (Inorganic Chemistry)     Full-text available via subscription   (Followers: 4)
Annual Reports Section B (Organic Chemistry)     Full-text available via subscription   (Followers: 9)
Annual Review of Chemical and Biomolecular Engineering     Full-text available via subscription   (Followers: 12)
Annual Review of Food Science and Technology     Full-text available via subscription   (Followers: 16)
Anti-Infective Agents     Hybrid Journal   (Followers: 3)
Antiviral Chemistry and Chemotherapy     Hybrid Journal   (Followers: 1)
Applied Organometallic Chemistry     Hybrid Journal   (Followers: 7)
Applied Spectroscopy     Full-text available via subscription   (Followers: 22)
Applied Surface Science     Hybrid Journal   (Followers: 28)
Arabian Journal of Chemistry     Open Access   (Followers: 6)
ARKIVOC     Open Access   (Followers: 2)
Asian Journal of Biochemistry     Open Access   (Followers: 1)
Atomization and Sprays     Full-text available via subscription   (Followers: 4)
Australian Journal of Chemistry     Hybrid Journal   (Followers: 7)
Autophagy     Hybrid Journal   (Followers: 2)
Avances en Quimica     Open Access   (Followers: 1)
Biochemical Pharmacology     Hybrid Journal   (Followers: 10)
Biochemistry     Full-text available via subscription   (Followers: 338)
Biochemistry Insights     Open Access   (Followers: 6)
Biochemistry Research International     Open Access   (Followers: 6)
BioChip Journal     Hybrid Journal  
Bioinorganic Chemistry and Applications     Open Access   (Followers: 9)
Bioinspired Materials     Open Access   (Followers: 5)
Biointerface Research in Applied Chemistry     Open Access   (Followers: 2)
Biointerphases     Open Access   (Followers: 1)
Biology, Medicine, & Natural Product Chemistry     Open Access   (Followers: 1)
Biomacromolecules     Full-text available via subscription   (Followers: 19)
Biomass Conversion and Biorefinery     Partially Free   (Followers: 10)
Biomedical Chromatography     Hybrid Journal   (Followers: 6)
Biomolecular NMR Assignments     Hybrid Journal   (Followers: 3)
BioNanoScience     Partially Free   (Followers: 5)
Bioorganic & Medicinal Chemistry     Hybrid Journal   (Followers: 121)
Bioorganic & Medicinal Chemistry Letters     Hybrid Journal   (Followers: 85)
Bioorganic Chemistry     Hybrid Journal   (Followers: 10)
Biopolymers     Hybrid Journal   (Followers: 18)
Biosensors     Open Access   (Followers: 2)
Biotechnic and Histochemistry     Hybrid Journal   (Followers: 1)
Bitácora Digital     Open Access  
Boletin de la Sociedad Chilena de Quimica     Open Access  
Bulletin of the Chemical Society of Ethiopia     Open Access   (Followers: 2)
Bulletin of the Chemical Society of Japan     Full-text available via subscription   (Followers: 24)
Bulletin of the Korean Chemical Society     Hybrid Journal   (Followers: 1)
C - Journal of Carbon Research     Open Access   (Followers: 3)
Cakra Kimia (Indonesian E-Journal of Applied Chemistry)     Open Access  
Canadian Association of Radiologists Journal     Full-text available via subscription   (Followers: 2)
Canadian Journal of Chemistry     Hybrid Journal   (Followers: 10)
Canadian Mineralogist     Full-text available via subscription   (Followers: 6)
Carbohydrate Research     Hybrid Journal   (Followers: 26)
Carbon     Hybrid Journal   (Followers: 68)
Catalysis for Sustainable Energy     Open Access   (Followers: 7)
Catalysis Reviews: Science and Engineering     Hybrid Journal   (Followers: 8)
Catalysis Science and Technology     Free   (Followers: 8)
Catalysis Surveys from Asia     Hybrid Journal   (Followers: 3)
Catalysts     Open Access   (Followers: 8)
Cellulose     Hybrid Journal   (Followers: 7)
Cereal Chemistry     Full-text available via subscription   (Followers: 5)
ChemBioEng Reviews     Full-text available via subscription   (Followers: 1)
ChemCatChem     Hybrid Journal   (Followers: 8)
Chemical and Engineering News     Free   (Followers: 16)
Chemical Bulletin of Kazakh National University     Open Access  
Chemical Communications     Full-text available via subscription   (Followers: 71)
Chemical Engineering Research and Design     Hybrid Journal   (Followers: 25)
Chemical Research in Chinese Universities     Hybrid Journal   (Followers: 3)
Chemical Research in Toxicology     Full-text available via subscription   (Followers: 22)
Chemical Reviews     Full-text available via subscription   (Followers: 186)
Chemical Science     Open Access   (Followers: 23)
Chemical Technology     Open Access   (Followers: 16)
Chemical Vapor Deposition     Hybrid Journal   (Followers: 5)
Chemical Week     Full-text available via subscription   (Followers: 8)
Chemie in Unserer Zeit     Hybrid Journal   (Followers: 56)
Chemie-Ingenieur-Technik (Cit)     Hybrid Journal   (Followers: 24)
ChemInform     Hybrid Journal   (Followers: 8)
Chemistry & Biodiversity     Hybrid Journal   (Followers: 7)
Chemistry & Biology     Full-text available via subscription   (Followers: 31)
Chemistry & Industry     Hybrid Journal   (Followers: 5)
Chemistry - A European Journal     Hybrid Journal   (Followers: 149)
Chemistry - An Asian Journal     Hybrid Journal   (Followers: 16)
Chemistry and Materials Research     Open Access   (Followers: 20)
Chemistry Central Journal     Open Access   (Followers: 4)
Chemistry Education Research and Practice     Free   (Followers: 5)
Chemistry in Education     Open Access   (Followers: 9)
Chemistry International     Hybrid Journal   (Followers: 2)
Chemistry Letters     Full-text available via subscription   (Followers: 42)
Chemistry of Materials     Full-text available via subscription   (Followers: 243)
Chemistry of Natural Compounds     Hybrid Journal   (Followers: 9)
Chemistry World     Full-text available via subscription   (Followers: 22)
Chemistry-Didactics-Ecology-Metrology     Open Access   (Followers: 1)
ChemistryOpen     Open Access   (Followers: 2)
Chemkon - Chemie Konkret, Forum Fuer Unterricht Und Didaktik     Hybrid Journal  
Chemoecology     Hybrid Journal   (Followers: 4)
Chemometrics and Intelligent Laboratory Systems     Hybrid Journal   (Followers: 14)
Chemosensors     Open Access  
ChemPhysChem     Hybrid Journal   (Followers: 11)
ChemPlusChem     Hybrid Journal   (Followers: 2)
ChemTexts     Hybrid Journal  
CHIMIA International Journal for Chemistry     Full-text available via subscription   (Followers: 2)
Chinese Journal of Chemistry     Hybrid Journal   (Followers: 6)
Chinese Journal of Polymer Science     Hybrid Journal   (Followers: 10)
Chromatographia     Hybrid Journal   (Followers: 24)
Chromatography     Open Access   (Followers: 2)
Clay Minerals     Full-text available via subscription   (Followers: 10)
Cogent Chemistry     Open Access  
Colloid and Interface Science Communications     Open Access  
Colloid and Polymer Science     Hybrid Journal   (Followers: 10)
Colloids and Surfaces B: Biointerfaces     Hybrid Journal   (Followers: 6)
Combinatorial Chemistry & High Throughput Screening     Hybrid Journal   (Followers: 4)
Combustion Science and Technology     Hybrid Journal   (Followers: 22)
Comments on Inorganic Chemistry: A Journal of Critical Discussion of the Current Literature     Hybrid Journal   (Followers: 2)
Composite Interfaces     Hybrid Journal   (Followers: 6)
Comprehensive Chemical Kinetics     Full-text available via subscription   (Followers: 2)
Comptes Rendus Chimie     Full-text available via subscription  
Comptes Rendus Physique     Full-text available via subscription   (Followers: 1)
Computational and Theoretical Chemistry     Hybrid Journal   (Followers: 9)
Computational Biology and Chemistry     Hybrid Journal   (Followers: 11)
Computational Chemistry     Open Access   (Followers: 2)
Computers & Chemical Engineering     Hybrid Journal   (Followers: 9)
Coordination Chemistry Reviews     Full-text available via subscription   (Followers: 3)
Copernican Letters     Open Access   (Followers: 1)
Corrosion Series     Full-text available via subscription   (Followers: 6)
Critical Reviews in Biochemistry and Molecular Biology     Hybrid Journal   (Followers: 5)
Croatica Chemica Acta     Open Access  
Crystal Structure Theory and Applications     Open Access   (Followers: 4)
CrystEngComm     Full-text available via subscription   (Followers: 13)
Current Catalysis     Hybrid Journal   (Followers: 2)
Current Chromatography     Hybrid Journal  
Current Green Chemistry     Hybrid Journal  
Current Metabolomics     Hybrid Journal   (Followers: 5)
Current Microwave Chemistry     Hybrid Journal  
Current Opinion in Colloid & Interface Science     Hybrid Journal   (Followers: 9)
Current Opinion in Molecular Therapeutics     Full-text available via subscription   (Followers: 18)
Current Research in Chemistry     Open Access   (Followers: 8)
Current Science     Open Access   (Followers: 64)
Dalton Transactions     Full-text available via subscription   (Followers: 23)
Detection     Open Access   (Followers: 2)
Developments in Geochemistry     Full-text available via subscription   (Followers: 2)
Diamond and Related Materials     Hybrid Journal   (Followers: 12)
Dislocations in Solids     Full-text available via subscription  
Doklady Chemistry     Hybrid Journal  
Drying Technology: An International Journal     Hybrid Journal   (Followers: 4)
Eclética Química     Open Access   (Followers: 1)
Ecological Chemistry and Engineering S     Open Access   (Followers: 3)
Ecotoxicology and Environmental Contamination     Open Access  

        1 2 3 4 | Last

Journal Cover BioNanoScience
  [SJR: 0.428]   [H-I: 10]   [5 followers]  Follow
   Partially Free Journal Partially Free Journal
   ISSN (Print) 2191-1630 - ISSN (Online) 2191-1649
   Published by Springer-Verlag Homepage  [2355 journals]
  • Antibacterial and Antibiofilm Potential of Green Synthesized Silver
           Nanoparticles against Imipenem Resistant Clinical Isolates of P.
    • Authors: Syed Ghazanfar Ali; Mohammad Azam Ansari; Haris M. Khan; Mohammad Jalal; Abbas Ali Mahdi; Swaranjit Singh Cameotra
      Abstract: Green chemistry is generating an increasing amount of interest for the synthesis of metal nanoparticles due to the cost-effectiveness and eco-friendly nature of the plants. The green approach of nanoparticle synthesis is a better substitute for the chemical and physical methods since there is no involvement of toxic chemicals. The objective of the present research was the synthesis of silver nanoparticles (AgNPs) using bark extract of the medicinal plant Holarrhena pubescens Wall ex G. Don (HP) and evaluating their antibacterial and antibiofilm properties against clinical isolates of P. aeruginosa. The HP-AgNPs were characterized by ultraviolet-visible spectroscopy, Fourier transform infra red, atomic force microscopy, and transmission electron microscopy (TEM). The synthesized HP-AgNPs were spherical in shape, and the average particle size as analyzed by TEM was 13.15 nm. The antibacterial potential of HP-AgNPs was evaluated by determining MIC (minimum inhibitory concentration) and MBC (minimum bactericidal concentration). The MIC was found to be in the range of 20–25 μg/ml. Further, the interaction of AgNPs with imipenem-resistant P. aeruginosa was analyzed by TEM. The rupturing of the cell membrane and cell wall was seen at the lethal concentration, and the nanoparticles entered the cell from the several sites that caused great damage to the cell which eventually led to cell death. The antibiofilm properties of HP-AgNPs against imipenem-resistant P. aeruginosa were demonstrated by CLSM (confocal laser scanning microscopy) using propidium iodide and ConA-FITC dye. CLSM images clearly show that as the concentration of HP-AgNPs increased, the number of biofilm-forming cells decreased due to the cell death. It was also observed that AgNPs inhibit or restrict the colonization and halts the formation of biofilm. The result obtained suggested that green-synthesized HP-AgNPs have great antibacterial and antibiofilm potential and could be used as an alternative agent to treat the infection caused by imipenem-resistant P. aeruginosa.
      PubDate: 2018-02-17
      DOI: 10.1007/s12668-018-0505-8
  • Morphological and Biomolecules Dynamics of Phytopathogenic Fungi Under
           Stress of Silver Nanoparticles
    • Authors: Magdah Ganash; T. M. Abdel Ghany; A. M. Omar
      Abstract: Antifungal impact of silver nanoparticles (AgNPs) was evaluated on the growth, morphological, and biomolecules dynamics of Fusarium culmorum and Alternaria alternata. It was revealed that the different concentrations of AgNPs caused inhibition of fungal growth and deformations of fungal structures especially at high concentrations 40 and 60 ppm of AgNPs. A. alternata conidiospores at 40 ppm of AgNPs was sharply deformed and their longitudinal sections disappeared. On the other hand, these fungi failed to produce conidiospores in the presence of 60 ppm of AgNPs but produced chlamydospores. The effect of AgNPs on amino and fatty acids of F. culmorum was investigated compared with the influence of silver nitrate (AgNO3). AgNPs at different applied concentrations stimulated the synthesis of the most detected amino acids including aspartic acid, threonine, serine, glutamic acid, glycine, alanine, valine, leucine, tyrosine, arginine, proline, and lysine. The concentration of detected amino acids increased with increasing AgNPs up to 60 ppm. Aspartic acid, serine, glycine, alanine, arginine, leucine, and proline concentrations were 11.52, 6.53, 21.51, 12.51, 27.34, 9.40, and 22.17 μg/ml compared with their concentrations 5.90, 0.34, 21.51, 12.51, 14.97, 6.86, and 9.91 μg/ml at 40 ppm of AgNPs and AgNO3, respectively. Numerous fatty acids were detected in low percentage in treated F. culmorum with AgNO3 or AgNPs compared with untreated (control). Only butyric was detected in high percentage (29.58 and 33.04% at 20 ppm of AgNPs and AgNO3, respectively) compared with their percentage 15.93% in control.
      PubDate: 2018-02-15
      DOI: 10.1007/s12668-018-0510-y
  • Antihepatotoxic Activity of Liposomal Silibinin
    • Authors: Sergey V. Lutsenko; Tatiana I. Gromovykh; Ivan I. Krasnyuk; Ivan A. Vasilenko; Nataliya B. Feldman
      Abstract: The liposomal form of silibinin was obtained, and its antihepatotoxic activity in mice was studied using a model of acute toxic hepatitis caused by injection of carbon tetrachloride or paracetamol. It was shown that the use of the drug in therapy or prevention regimens leads to normalization of levels of transaminases and total protein in the blood of experimental animals. The results of the study showed that liposomal silibinin when administered intravenously shows a more pronounced hepatoprotective effect compared to intragastric administration of free silibinin. Thus, the effectiveness of the therapeutic action of silibinin can be significantly increased by using its liposomal form. Liposomal drug, in contrast to native silibinin, can be injected directly into the blood that significantly increases its bioavailability.
      PubDate: 2018-02-09
      DOI: 10.1007/s12668-018-0512-9
  • Effect of Iron Oxide Nanoparticle Shape on Doxorubicin Drug Delivery
           Toward LNCaP and PC-3 Cell Lines
    • Authors: T. R. Nizamov; A. S. Garanina; I. S. Grebennikov; O. A. Zhironkina; O. S. Strelkova; I. B. Alieva; I. I. Kireev; M. A. Abakumov; A. G. Savchenko; A. G. Majouga
      Abstract: In this paper, we investigated the delivery efficiency of doxorubicin by magnetite nanoparticles with different shape to LNCaP and PC-3 prostate cancer cell lines. Cubic and spherical nanoparticles of magnetite were synthesized in organic medium and hydrophilized by non-ionic surfactant Pluronic F127—polyethylene-polypropylene oxide polymer. Doxorubicin was loaded into hydrophobic region of polymeric shell. We have observed that cytotoxicity and distribution of doxorubicin in cells changed significantly in case of drug loaded into nanoparticles in comparison with free doxorubicin. We have shown that this change is due to two main reasons: (1) slower internalization of nanoparticles by cells compared to free doxorubicin and (2) slow and incomplete release of doxorubicin from nanoparticle polymer shell. Interestingly, nanoparticle shape influenced cytotoxicity and the dynamics of drug accumulation inside cancer cells. We have found that doxorubicin-loaded cubic nanoparticles were more toxic for both cell lines compared to spherical ones. Moreover, doxorubicin from cubic nanoparticles accumulated in cells faster than the drug loaded in spherical nanoparticles. So, our work shows that for efficient drug delivery, not only size and coating should be taken into account but also the shape of initial core as it plays an important role in nanoparticle interaction with cells.
      PubDate: 2018-02-09
      DOI: 10.1007/s12668-018-0502-y
  • Efficiency of Kinesio Taping in Adolescents with Cervicogenic Headache: a
           Blind Placebo-Controlled Study
    • Authors: Oleg Radievich Esin; Ilshat Khamzovich Khairullin; Radiy Germanovich Esin
      Abstract: The research covered 101 adolescents aged 14–16 years with cervicogenic headache (CHA) caused by myogenic trigger zones (MTZ) in the neck muscles. The research aims at estimation of elastic kinesio taping effectiveness in the treatment of myogenic CHA in adolescents. Patients were divided into three groups: 34 teenagers (Group A) were treated with kinesio tapes, 34 teenagers (Group B) received placebo—the simulation of kinesio tapes with a non-elastic medical hypoallergenic plaster (similar to the width of elastic tapes), 33 teenagers (Group C) were prescribed physical exercises for 20 min for the formation of correct motor stereotype. All indicators were evaluated before treatment (Eval-1), immediately after 1 month of treatment (Eval-2) and 1 month after treatment (Eval-3). At Eval-2 in Group A, there were observed statistically significant decrease in the number of days with a headache and headache intensity, and also increase in pain thresholds. In Groups B and C, there were no statistically significant changes in the indices compared to the Eval-1. At Eval-3 in the Group A, there was recorded positive dynamics in the studied indicators. In Group C, there was a positive statically significant dynamics, in comparison with Eval-1. There were no statistically significant changes in the patients of Group B. Group A in all indicators was statistically significant superior to the results of B and C. The authors conclude that kinesio taping is effective in treating myogenic CHA in the presence of an upper cross syndrome of muscle imbalance in adolescents.
      PubDate: 2018-02-05
      DOI: 10.1007/s12668-018-0506-7
  • The Langmuir Technique Applied to the Study of Natural Tears
    • Authors: E. Guaus; J. Torrent-Burgués
      Abstract: As a new proposal, natural tears collected from the Schirmer strips were studied using surface pressure-area, π-A, isotherms obtained with the Langmuir technique. Parameters such as limit surface pressure, πlimit, elastic modulus at the maximum, CS−1max, and surface pressure at the maximum, πmax, were correlated with clinical tests, such as the Schirmer (SCH) and the tear film breakup-time (TFBUT) tests. The analysis from the chi-square test indicates dependence between the SCH test and the type of isotherms with a value of P < 0.05. A moderate Pearson correlation coefficient with statistical significance (P < 0.05) between the values of the SCH test and the πlimit was obtained. On the other hand, a low Pearson correlation coefficient with no statistical significance (P > 0.05) between the values of the TFBUT test and the πlimit was obtained. Additionally, considering only the isotherms classified as good, moderate Pearson correlation coefficients with statistical significance (P < 0.05) between the values of the TFBUT test and πlimit or πmax can be obtained. This study shows that the isotherms obtained with the Langmuir technique correlate well with the tear secretion, and when the later is moderate or good, the isotherm parameters afford information about the tear film stability and the behaviour of the tear lipids.
      PubDate: 2018-01-26
      DOI: 10.1007/s12668-018-0509-4
  • Treatment of Tension-Type Headaches in Adolescents (14–15 Years Old):
           the Efficacy of Aminophenylbutyric Acid Hydrochloride
    • Authors: Oleg Radievich Esin
      Abstract: The paper represents a modern view on the problem of tension-type headache (TTH) in adolescents, which is caused by the following factors: information overload and other types of stress, sleep deprivation, and physical activity deficiency, impaired posture with myogenic trigger points developing. The research covered 64 adolescents aged 14–15 with tension-type headaches: 33 boys and 42 girls (11 boys and 20 girls with frequent episodic tension-type headache (ETTH) and 12 boys and 21 girls with chronic tension-type headache (CTTH)). We assessed accompanying symptoms over the last 6 months according to the Likert scale. All children were prescribed GABA receptor agonist—aminophenylbutyric acid hydrochloride 250 mg three times a day for 3 weeks. The reduction of tension-type headache intensity was assessed by 3-grade scale: “no change,” “significantly reduced,” and “completely stopped”: 0—no, 1—very seldom, 2—often, and 3—permanently. ETTH/CTTH associated symptoms are as follows: (1) difficulty of falling asleep and restless sleep (0.91 ± 0.83/1.54 + 1.26), (2) difficulty of concentrating during the day (0.61 + 0.92/2.04 + 1.21), (3) morning sickness (0.32 + 0.87/1.81 + 1.29), (4) feeling ill in the morning with improvement in the second half of the day (0.17 + 0.57/1 95 + 0.95), (5) meteosensitivity (0.58 + 1.01/1.59 + 1.22), and (6) decrease in physical capability (0.20 + 0.64/1.72 + 0.82). After 3 weeks, the pain in ETTH subgroup completely stopped in 27 children (79%) and significantly reduced in 7 (21%). In CTTH subgroup, the pain completely stopped in 9 children (41%) and significantly reduced in 13 (59%). Associated symptoms of ETTH/CTTH are as follows: (1) difficulty of falling asleep and restless sleep (0.26 + 0.44, p = 0.000093/0.45 + 0.80, p = 0.000224), (2) difficulty of concentrating during the day (0.17 + 0.38, p = 0.003707/0.54 + 0.85; p = 0.000007), (3) morning sickness (0.08 + 0.28, p = 0. 058101/0.77 + 1.06, p = 0.001682), (4) feeling ill in the morning with improvement in the second half of the day (0.08 + 0.28, p = 0.083119/0.27 + 0.45; p = 0.000000), (5) meteosensitivity (0.32 + 0.63, p = 0.010304/1.36 + 1.09, p = 0.021450), and (6) decrease in physical capability (0.058 + 0 23; p = 0.133706 / 0.95 + 1.04, p = 0.005055). Aminophenylbutyric acid hydrochloride (GABA receptor agonist) reduces the intensity of tension-type headache and has a positive effect on associated symptoms. It can be recommended for inclusion into the scheme of tension-type headache treatment in schoolchildren.
      PubDate: 2018-01-24
      DOI: 10.1007/s12668-018-0507-6
  • Green Synthesis of Copper Oxide Nanoparticles Using Ixiro coccinea Plant
           Leaves and its Characterization
    • Authors: Kiran Vishveshvar; M. V. Aravind Krishnan; K. Haribabu; S. Vishnuprasad
      Abstract: A green method using biological dependable processes has been established for the synthesis of CuO nanoparticles. Synthesis of CuO nanoparticles were done using an environmental friendly method by taking aqueous solution of copper(II) sulfate and leaf extract of Ixoro coccinea. Characterization of the synthesized CuO nanoparticles was done using instruments such as UV-visible spectrophotometer, scanning electron microscopy, transmission electron microscopy, and Fourier-transform infrared spectroscopy. The existence of peaks obtained in FTIR confirms CuO nanoparticles. A visible change was observed in the solution prepared as it changed from light blue to light brown to dark brown once the extract was added to the copper sulfate solution. An average size of 300 nm was obtained during SEM analysis due to the formation of nanoparticle clusters. The TEM images of CuO nanoparticles separated after ultrasonication of the dispersion show that they possess an average size of 80–110 nm. It was found that the ultrasonication increases the distribution of nanoparticles in a fluid by preventing the formation of clusters. It was found that Ixiro coccinea plant leaves are a suitable alternative for the easy and green synthesis of CuO nanoparticles.
      PubDate: 2018-01-22
      DOI: 10.1007/s12668-018-0508-5
  • Positively Charged Gold Nanoparticles for Hydrogen Peroxide Detection
    • Authors: Mohammad Mansoob Khan; Moo Hwan Cho
      Abstract: This paper reports the synthesis of positively charged gold nanoparticles [(+)AuNPs] for the colorimetric detection of hydrogen peroxide (H2O2). (+)AuNPs were synthesized using an electrochemically active biofilm in an aqueous solution, which is a novel, simple, and green approach. The as-synthesized (+)AuNPs were characterized by ultraviolet-visible (UV-Vis) spectroscopy, dynamic light scattering (DLS), X-ray diffraction (XRD), transmission electron microscopy (TEM), and high-resolution TEM (HRTEM). UV-Vis spectroscopy confirmed the synthesis of AuNPs and DLS showed that the as-synthesized AuNPs had a charge of +32.72 mV. XRD confirmed the formation of AuNPs as well as the purity, crystallinity, and fcc structure. TEM and HRTEM showed that (+)AuNPs were 15–21 nm in size and spherical in shape. The as-synthesized (+)AuNPs were used for the colorimetric detection of H2O2 using 3,3,5,5-tetramethylbenzidine dihydrochoride. This study provides a simple, fast, and sensitive colorimetric method for the detection of H2O2 in the linear range from 1.0 × 10−3 to 2.5 × 10−3 M. The (+)AuNPs possessed extraordinary intrinsic peroxidase-like activity (peroxidase mimic) compared to citrate-capped negatively charged AuNPs. This approach to the colorimetric detection of H2O2 is novel and simple because it uses positively charged gold nanoparticles, which may provide new areas for further research.
      PubDate: 2018-01-20
      DOI: 10.1007/s12668-018-0503-x
  • Early Diagnosis of Breast Cancer: Public Health and Mammographic Screening
    • Authors: Rinat Gamirov; Ludmila Komarova; Rustem Khasanov; Regina Gamirova
      Abstract: Malignant breast tumors are the leading oncological pathology (after skin cancer) in the female population all over the world (more than 20%). According to American Cancer Society, breast cancer is expected to account for 30% of all new cancer cases among women in 2017 (Simon, 2017). The research in the sphere of the timely diagnosis of malignant neoplasms led to the development and further widespread implementation of screening programs, which help to reveal the disease before the onset of symptoms or signs of illness. The paper discusses different scientific approaches to mass screening, various opinions concerning the real impact of screening and contemporary treatment into breast cancer mortality decrease, and presents the results of a breast screening program in the Republic of Tatarstan (Russian Federation). The results showed the effectiveness of this diagnostic method: in 59,000 women aged 50–69 years in total, there were revealed 373 cases of breast cancer (0.63%), in which breast cancer of the I–II stage was 80%. Of the histological forms, 45.4% in the detected malignant neoplasms were presented by invasive ductal cancer, 24.8%—by invasive lobular carcinoma, and the proportion of non-invasive cancer was 4%. Cancer without metastatic involvement of lymphatic nodes (T1–4N0) occurred in 63% of cases. The paper discusses such negative factors of mass mammographic screening as overdiagnosis, false-positive results, and overtreatment. The analyses of existing research all over the world show that since the problem has been actively studied all over the world, the approach to the analysis of screening results has changed to the prevalence of individual approach to each case, the number of cases connected with overdiagnosis is constantly reduced, and the quality of visualization is rapidly improving due to the success of interdisciplinary research and rapid technical progress.
      PubDate: 2018-01-18
      DOI: 10.1007/s12668-018-0504-9
  • Prediction of Aromatic Hydroxylation Sites for Human CYP1A2 Substrates
           Using Condensed Graph of Reactions
    • Authors: T. I. Madzhidov; A. A. Khakimova; R. I. Nugmanov; C. Muller; G. Marcou; A. Varnek
      Abstract: In this paper, support vector machine and condensed graph of reaction (CGR) approaches have been used to predict the regioselectivity of aromatic hydroxylation for human CYP1A2 substrates. Experimental data on aromatic hydroxylation for human cytochrome CYP1A2 (observed molecular or “real” transformations) used in the modeling were extracted from the Metabolite database and the XenoSite database. In addition, all potential but unobserved (“unreal”) transformations were generated. The dataset containing “real” and “unreal” transformations was converted into an ensemble of CGRs representing pseudomolecules with conventional (single, double, aromatic, etc.) bonds and dynamic bonds characterizing chemical transformations. ISIDA fragment descriptors generated for CGRs were used for the modeling. The models have been validated in three times repeated fivefold cross-validation on the training set and then on an external set. The final model was constructed by consensus over models built on different descriptors sets. Predictive performance of our model on the external test set was similar to that of XenoSite and Way2Drug tools. Unlike previously used atom labeling-based approaches, the proposed CGR-based representation of metabolic transformations could be applied to different types of reactions catalyzed by the same enzyme and therefore, it is more suitable for automatized handling of metabolic data.
      PubDate: 2018-01-16
      DOI: 10.1007/s12668-017-0499-7
  • Fourier Transform Infrared Spectroscopy Analysis of Human Osteosarcoma
           Bone Tissue
    • Authors: Vitaly V. Chasov; Ivan S. Raginov; Svetlana N. Medvedeva; Il’dar Safin; Albert A. Rizvanov
      Abstract: Since the middle of the XXth century, Fourier transform infrared (FT-IR) spectroscopy has been employed as a nondestructive, label-free, highly sensitive, and specific analytical method with many potential applications in different fields of biomedical research and in particular cancer research and diagnosis. In this study, infrared spectra of normal human bone and tumor tissue of osteosarcoma were analyzed using FT-IR spectroscopy in the range of 800–1800 cm−1. The results revealed that some of the spectral characteristics varied significantly between normal and malignant tissues, that is, IR peak positions, and the spectral intensities. The main changes in the spectral features of tissues were observed in the phosphate ν1, ν3 contour (950–1200 cm−1) and Amide I (1620–1680 cm−1) and II (1520–1570 cm−1) bands. The molecular interpretation of the differences between normal and pathological states of bone tissues may indicate the changes in hydroxyapatite mineralization and collagen structure of the malignant tissue. The most important application of this technique is evaluation of the disease states and the results of therapeutic intervention under the medical treatment.
      PubDate: 2018-01-16
      DOI: 10.1007/s12668-018-0500-0
  • Nucleotide Polymorphism in the Iron Utilization System Gene isdB NEAT
           Domain Affects Heme-Binding Ability of IsdB Protein in Various Human
           Strains of Staphylococcus aureus
    • Authors: Yuriy Aleksandrovich Tyurin; S. A. Lysovskaya; S. N. Kulikov; I. D. Reshetnikova; Guzel Shavhatovna Isaeva; Sergey P. Morzunov
      Abstract: Genetic heterogeneity of the isdB gene fragment encoding one of two heme-binding NEAr Transporter (NEAT) domains pfam05031 in different isolates of Staphylococcus aureus from the healthy carriers and the risk group patients (chronic inflammatory infections of the upper respiratory tract and middle ear) was investigated. All S. aureus strains included in the current study differed phenotypically from one another by degree of affinity to polystyrene with immobilized human hemoglobin. The isolates that displayed low affinity to hemoglobin were found to have more mutations within the isdB gene fragment which encodes one of the IsdB protein domains containing heme-binding sites.
      PubDate: 2018-01-15
      DOI: 10.1007/s12668-018-0501-z
  • Effects of Serotonin Receptor Antagonist Methiothepin on Membrane
           Potential of Premotor Interneurons of Naïve and Learned Snails
    • Authors: Vyatcheslav V. Andrianov; Tatiana Kh. Bogodvid; Irina B. Deryabina; Aleksandra N. Golovchenko; Lyudmila N. Muranova; Khalil L. Gainutdinov
      Abstract: It was shown that the application of methiothepin, the antagonist of serotonin (5-HT) receptors, caused a decrease in the membrane potential of the high-threshold premotor interneurons LPa3 and RPa3 of the intact snails and its increase to the previous level after the subsequent application of 5-HT in vitro. The application of methiothepin also led to a decrease in the membrane potential of these neurons, but the subsequent application of 5-HT did not lead to the return of the membrane potential to the previous level in animals trained in defensive reflex. It can be assumed that conditioning of the defensive reflex causes a state change of the 5-HT receptor system of premotor interneurons of defensive behavior.
      PubDate: 2018-01-13
      DOI: 10.1007/s12668-017-0498-8
  • Preventing Common Hereditary Disorders through Time-Separated Twinning
    • Authors: Alexander Churbanov; Levon Abrahamyan
      Abstract: Biomedical advances have led to a relaxation of natural selection in the human population of developed countries. In the absence of strong purifying selection, spontaneous and frequently deleterious mutations tend to accumulate in the human genome and gradually increase the genetic load; that is, the frequency of potentially lethal genes in the gene pool. Gradual increase in incidence of many complex disorders suggests deleterious impact of the genetic load on human well-being. Recent advances in in vitro fertilization (IVF) combined with artificial twinning and transgenerational embryo cryoconservation offer the possibility of preventing significant accumulation of genetic load and reducing the incidence of hereditary disorders. Many complex diseases such as type 1 and 2 diabetes, autism, bipolar disorder, allergies, Alzheimer’s disease, and some cancers show significantly higher concordance in monozygotic (MZ) twins than in fraternal twins (dizygotic, DZ) or parent-child pairs, suggesting their etiology is strongly influenced by genetics. Preventing these diseases based on genetic data alone is frequently impossible due to the complex interplay between genetic and environmental factors. We hypothesize that the incidence of complex diseases could be significantly reduced in the future through a strategy based on time-separated twinning. This strategy involves the collection and fertilization of human oocytes followed by several rounds of artificial twinning. If preimplantation genetic screening (PGS) reports no aneuploidy or known Mendelian disorders, one of the MZ siblings would be implanted and the remaining embryos cryoconserved. Once the good health of the adult MZ sibling(s) is established, subsequent parenthood with the cryoconserved co-twins could substantially lower the incidence of hereditary disorders with complex etiology and virtually eradicate simple Mendelian disorders. The proposed method of artificial twinning has the potential to alleviate suffering and reduce the negative social impact induced by dysgenic effects associated with known and unknown genetic factors. Time-separated twinning has the capacity to prevent further accumulation of the genetic load and to provide source of isogenic embryonic stem cells for future regenerative therapies.
      PubDate: 2018-01-13
      DOI: 10.1007/s12668-017-0488-x
  • Whether Medical Schools in Russia Are Ready to Develop Successfully in the
           Twenty-first Century
    • Authors: Andrey Kiassov; Anisa Gumerova; Sayar Abdulkhakov; Rashat Faizullin; Marat Mrasov; Lenar Rashitov; Raushania Gaifullina; Rezeda Khasanova; Julia Oslopova; Albert Rizvanov
      Abstract: The main purpose of this work was to analyze the situation of the readiness of Russian medical schools to develop and implement new technologies such as bionanotechnology and technologies born as the result of the genome and the fourth industrial revolutions, which are at the intersection of various sciences and can become a breakthrough in the development of future medicine. The development of medical schools in Russia, special features of Russian medical education, types of medical schools, and their effectiveness at the present time are considered in the paper. However, the most interesting development of new technologies is that of the “fundamental specialties” of training in higher education—medical biochemistry, medical biophysics, and medical cybernetics. We assert that Russian medical schools attached to large, traditional universities, thanks to multidisciplinarity and convergence in scientific research and in education, are the most prepared to solve the tasks posed by the global challenges of our time.
      PubDate: 2018-01-06
      DOI: 10.1007/s12668-017-0495-y
  • Design of Dual Band Wireless Power and Data Through RF Transmission for
           Biomedical Implants
    • Authors: Dhoha Daoud; Maissa Daoud; Mohamed Ghorbel; Ahmed Ben Hamida
      Abstract: In this paper, a new data and power recovery architecture for biomedical microsystem implants is proposed. Our contribution aims to overcome problems resulted by the trade-off between transmission data rate and power consumption for systems using the same or the separate inductive link to transmit data and power to the implanted part. The dual separate channels of RF powering and data recovery parts are designed to achieve the back telemetry data and power supply. The RF power recovery system is based on a 4-MHz RF link signal. It provides a regulated 3.3 V for the stimulating stage and 0.9 V for data recovery stage. The receiver based on a non-coherent topology consists of a 3–5-GHz low-noise amplifier (LNA), a squarer, an integrator, and a high-speed decision stage. The LNA of cascaded by cascode inductive source degenerative approach is proposed to decrease the noise figure when respecting linearity and stability conditions. It dissipates 8.89 mA from the 0.9-V power supply. The pulse generator produces an output signal with a maximum power spectral density (PSD) of − 66 dBm/MHz. The power consumption of the data transmission system is approximately equal to 0.664 mW for the emitter and 9.17 mW for the receiver. Simulation results show that this configuration can achieve a 125-Mbps data rate and − 82 dBm at 125-Mbps receiving sensitivity. This topology was designed in 0.18-μm RF-CMOS technology.
      PubDate: 2018-01-06
      DOI: 10.1007/s12668-017-0472-5
  • Analysis of Apparent Catalytic Parameters of Multiple Molecular Forms of
           Human Plasma Butyrylcholinesterase by Activity Gel-Scanning Following
           Non-denaturing Electrophoresis
    • Authors: Patrick Masson; Sofya Lushchekina
      Abstract: Butyrylcholinesterase (BChE) in human plasma is composed of four molecular forms: C1 (monomer); C2, covalent conjugate between BChE monomer and albumin; C3, dimer; and C4, tetramer, the major form. Catalytic parameters of molecular forms were estimated at high substrate concentration after non-denaturing polyacrylamide gel electrophoresis by activity gel-scanning densitometry, using a chromogenic substrate (butyrylthiocholine (BTC)). Though catalytic parameters Kss (dissociation of enzyme substrate complex at high substrate concentration) and catalytic constants are apparent (phenomenological) parameters, results indicate that the four molecular forms of human BChE do not display significant differences in their catalytic behavior at high BTC concentration.
      PubDate: 2018-01-05
      DOI: 10.1007/s12668-017-0489-9
  • Approximation of the Dependency of Trace Elements Concentrations in
           Internal Media upon their Contents in Environment Objects
    • Authors: Tunakova Yulia Alekseevna; Novikova Svetlana Vladimirovna; Faizullin Rashat Iskanderovich; Valiev Vsevolod Sergeevich
      Abstract: Models that demonstrate the dependency of a trace element content in the internal milieu of an organism upon that in external media objects of the environment were developed to identify dominant factors in ecology-mediated microelement imbalance in a human body. Based on the sets of experimental data obtained on trace element concentrations in the internal milieu (fluids) of a human body (blood) and accumulating media (hair), external fluids (drinking water), and deposit media (soil and snow cover), the degree of approximation of dependencies captured with different models was estimated, with the most adequate ones chosen. Linear, cubic, logistic, sigmoidal, parabolic functions, a polynomial of the fourth and fifth degrees, the Nelder–Mead optimization algorithm, and a Boltzmann function were applied to evaluate the approximation degree by different models. The selection of internal and external media demonstrating the best approximation results is justified.
      PubDate: 2018-01-04
      DOI: 10.1007/s12668-017-0487-y
  • Intravenous Transplantation of Human Umbilical Cord Blood Mononuclear
           Cells Overexpressing Nerve Growth Factor Improves Spatial Memory in
           APP/PS1 Transgenic Mice with a Model of Alzheimer’s Disease
    • Authors: M. A. Mukhamedyarov; A. V. Leushina; A. E. Tikhonova; E. O. Petukhova; E. E. Garanina; R. Ben Taleb; M. S. Kaligin; Y. O. Mukhamedshina; A. A. Rizvanov; A. L. Zefirov; R. R. Islamov
      Abstract: Alzheimer’s disease is a progressive incurable neurodegenerative disease manifested by dementia and other cognitive disorders. Gene-cell therapy is one of the most promising trends in the development of treatment for Alzheimer’s disease. The study was aimed to evaluate the therapeutic potential of intravenous transplantation of human umbilical cord blood mononuclear cells (UCBMCs) transduced with adenoviral vectors overexpressing nerve growth factor (NGF) for the treatment of Alzheimer’s disease in an APP/PS1 transgenic mice model. The transplantation of NGF-expressing UCBMCs was found to improve spatial memory and decrease anxiety in APP/PS1 mice. Grafted cells and their expression of NGF were detected in the cortex and hippocampus of transgenic mice in the period up to 90 days after transplantation. Thus, gene-cell therapy based on the use of NGF-overexpressing UCBMCs is a promising approach for the development of Alzheimer’s disease treatments.
      PubDate: 2017-12-29
      DOI: 10.1007/s12668-017-0497-9
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