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CHEMISTRY (597 journals)                  1 2 3 | Last

Showing 1 - 200 of 735 Journals sorted alphabetically
2D Materials     Hybrid Journal   (Followers: 7)
Accreditation and Quality Assurance: Journal for Quality, Comparability and Reliability in Chemical Measurement     Hybrid Journal   (Followers: 26)
ACS Catalysis     Full-text available via subscription   (Followers: 31)
ACS Chemical Neuroscience     Full-text available via subscription   (Followers: 17)
ACS Combinatorial Science     Full-text available via subscription   (Followers: 23)
ACS Macro Letters     Full-text available via subscription   (Followers: 22)
ACS Medicinal Chemistry Letters     Full-text available via subscription   (Followers: 39)
ACS Nano     Full-text available via subscription   (Followers: 217)
ACS Photonics     Full-text available via subscription   (Followers: 10)
ACS Synthetic Biology     Full-text available via subscription   (Followers: 20)
Acta Chemica Iasi     Open Access   (Followers: 2)
Acta Chimica Sinica     Full-text available via subscription  
Acta Chimica Slovaca     Open Access   (Followers: 1)
Acta Chromatographica     Full-text available via subscription   (Followers: 9)
Acta Facultatis Medicae Naissensis     Open Access  
Acta Metallurgica Sinica (English Letters)     Hybrid Journal   (Followers: 5)
Acta Scientifica Naturalis     Open Access   (Followers: 2)
adhäsion KLEBEN & DICHTEN     Hybrid Journal   (Followers: 5)
Adhesion Adhesives & Sealants     Hybrid Journal   (Followers: 7)
Adsorption Science & Technology     Full-text available via subscription   (Followers: 5)
Advanced Functional Materials     Hybrid Journal   (Followers: 48)
Advanced Science Focus     Free   (Followers: 3)
Advances in Chemical Engineering and Science     Open Access   (Followers: 53)
Advances in Chemical Science     Open Access   (Followers: 12)
Advances in Chemistry     Open Access   (Followers: 12)
Advances in Colloid and Interface Science     Full-text available via subscription   (Followers: 18)
Advances in Drug Research     Full-text available via subscription   (Followers: 22)
Advances in Enzyme Research     Open Access   (Followers: 10)
Advances in Fluorine Science     Full-text available via subscription   (Followers: 8)
Advances in Fuel Cells     Full-text available via subscription   (Followers: 14)
Advances in Heterocyclic Chemistry     Full-text available via subscription   (Followers: 8)
Advances in Materials Physics and Chemistry     Open Access   (Followers: 18)
Advances in Nanoparticles     Open Access   (Followers: 12)
Advances in Organometallic Chemistry     Full-text available via subscription   (Followers: 15)
Advances in Polymer Science     Hybrid Journal   (Followers: 40)
Advances in Protein Chemistry     Full-text available via subscription   (Followers: 18)
Advances in Protein Chemistry and Structural Biology     Full-text available via subscription   (Followers: 18)
Advances in Quantum Chemistry     Full-text available via subscription   (Followers: 5)
Advances in Science and Technology     Full-text available via subscription   (Followers: 10)
African Journal of Bacteriology Research     Open Access  
African Journal of Chemical Education     Open Access   (Followers: 2)
African Journal of Pure and Applied Chemistry     Open Access   (Followers: 7)
Agrokémia és Talajtan     Full-text available via subscription   (Followers: 2)
Alkaloids: Chemical and Biological Perspectives     Full-text available via subscription   (Followers: 3)
AMB Express     Open Access   (Followers: 1)
Ambix     Hybrid Journal   (Followers: 3)
American Journal of Biochemistry and Biotechnology     Open Access   (Followers: 65)
American Journal of Biochemistry and Molecular Biology     Open Access   (Followers: 14)
American Journal of Chemistry     Open Access   (Followers: 25)
American Journal of Plant Physiology     Open Access   (Followers: 13)
American Mineralogist     Full-text available via subscription   (Followers: 12)
Analyst     Full-text available via subscription   (Followers: 38)
Angewandte Chemie     Hybrid Journal   (Followers: 153)
Angewandte Chemie International Edition     Hybrid Journal   (Followers: 203)
Annales UMCS, Chemia     Open Access   (Followers: 1)
Annals of Clinical Chemistry and Laboratory Medicine     Open Access   (Followers: 1)
Annual Reports in Computational Chemistry     Full-text available via subscription   (Followers: 3)
Annual Reports Section A (Inorganic Chemistry)     Full-text available via subscription   (Followers: 3)
Annual Reports Section B (Organic Chemistry)     Full-text available via subscription   (Followers: 7)
Annual Review of Chemical and Biomolecular Engineering     Full-text available via subscription   (Followers: 12)
Annual Review of Food Science and Technology     Full-text available via subscription   (Followers: 14)
Anti-Infective Agents     Hybrid Journal   (Followers: 3)
Antiviral Chemistry and Chemotherapy     Hybrid Journal  
Applied Organometallic Chemistry     Hybrid Journal   (Followers: 6)
Applied Spectroscopy     Full-text available via subscription   (Followers: 22)
Applied Surface Science     Hybrid Journal   (Followers: 26)
Arabian Journal of Chemistry     Open Access   (Followers: 6)
ARKIVOC     Open Access   (Followers: 2)
Asian Journal of Biochemistry     Open Access   (Followers: 1)
Atomization and Sprays     Full-text available via subscription   (Followers: 3)
Australian Journal of Chemistry     Hybrid Journal   (Followers: 7)
Autophagy     Hybrid Journal   (Followers: 2)
Avances en Quimica     Open Access   (Followers: 1)
Biochemical Pharmacology     Hybrid Journal   (Followers: 9)
Biochemistry     Full-text available via subscription   (Followers: 277)
Biochemistry Insights     Open Access   (Followers: 5)
Biochemistry Research International     Open Access   (Followers: 6)
BioChip Journal     Hybrid Journal  
Bioinorganic Chemistry and Applications     Open Access   (Followers: 9)
Bioinspired Materials     Open Access   (Followers: 3)
Biointerface Research in Applied Chemistry     Open Access   (Followers: 2)
Biointerphases     Open Access   (Followers: 1)
Biology, Medicine, & Natural Product Chemistry     Open Access  
Biomacromolecules     Full-text available via subscription   (Followers: 18)
Biomass Conversion and Biorefinery     Partially Free   (Followers: 10)
Biomedical Chromatography     Hybrid Journal   (Followers: 6)
Biomolecular NMR Assignments     Hybrid Journal   (Followers: 3)
BioNanoScience     Partially Free   (Followers: 4)
Bioorganic & Medicinal Chemistry     Hybrid Journal   (Followers: 107)
Bioorganic & Medicinal Chemistry Letters     Hybrid Journal   (Followers: 99)
Bioorganic Chemistry     Hybrid Journal   (Followers: 10)
Biopolymers     Hybrid Journal   (Followers: 18)
Biosensors     Open Access   (Followers: 2)
Biotechnic and Histochemistry     Hybrid Journal   (Followers: 1)
Bitácora Digital     Open Access  
Boletin de la Sociedad Chilena de Quimica     Open Access  
Bulletin of the Chemical Society of Ethiopia     Open Access   (Followers: 2)
Bulletin of the Chemical Society of Japan     Full-text available via subscription   (Followers: 24)
Bulletin of the Korean Chemical Society     Hybrid Journal   (Followers: 1)
C - Journal of Carbon Research     Open Access   (Followers: 2)
Canadian Association of Radiologists Journal     Full-text available via subscription   (Followers: 2)
Canadian Journal of Chemistry     Full-text available via subscription   (Followers: 10)
Canadian Mineralogist     Full-text available via subscription   (Followers: 3)
Carbohydrate Research     Hybrid Journal   (Followers: 26)
Carbon     Hybrid Journal   (Followers: 67)
Catalysis for Sustainable Energy     Open Access   (Followers: 6)
Catalysis Reviews: Science and Engineering     Hybrid Journal   (Followers: 8)
Catalysis Science and Technology     Free   (Followers: 6)
Catalysis Surveys from Asia     Hybrid Journal   (Followers: 3)
Catalysts     Open Access   (Followers: 7)
Cellulose     Hybrid Journal   (Followers: 7)
Cereal Chemistry     Full-text available via subscription   (Followers: 4)
ChemBioEng Reviews     Full-text available via subscription   (Followers: 1)
ChemCatChem     Hybrid Journal   (Followers: 8)
Chemical and Engineering News     Free   (Followers: 12)
Chemical Bulletin of Kazakh National University     Open Access  
Chemical Communications     Full-text available via subscription   (Followers: 69)
Chemical Engineering Research and Design     Hybrid Journal   (Followers: 23)
Chemical Research in Chinese Universities     Hybrid Journal   (Followers: 3)
Chemical Research in Toxicology     Full-text available via subscription   (Followers: 19)
Chemical Reviews     Full-text available via subscription   (Followers: 165)
Chemical Science     Open Access   (Followers: 21)
Chemical Technology     Open Access   (Followers: 15)
Chemical Vapor Deposition     Hybrid Journal   (Followers: 4)
Chemical Week     Full-text available via subscription   (Followers: 7)
Chemie in Unserer Zeit     Hybrid Journal   (Followers: 55)
Chemie-Ingenieur-Technik (Cit)     Hybrid Journal   (Followers: 25)
ChemInform     Hybrid Journal   (Followers: 7)
Chemistry & Biodiversity     Hybrid Journal   (Followers: 6)
Chemistry & Biology     Full-text available via subscription   (Followers: 30)
Chemistry & Industry     Hybrid Journal   (Followers: 5)
Chemistry - A European Journal     Hybrid Journal   (Followers: 136)
Chemistry - An Asian Journal     Hybrid Journal   (Followers: 15)
Chemistry and Materials Research     Open Access   (Followers: 17)
Chemistry Central Journal     Open Access   (Followers: 4)
Chemistry Education Research and Practice     Free   (Followers: 5)
Chemistry in Education     Open Access   (Followers: 9)
Chemistry International     Hybrid Journal   (Followers: 2)
Chemistry Letters     Full-text available via subscription   (Followers: 43)
Chemistry of Materials     Full-text available via subscription   (Followers: 189)
Chemistry of Natural Compounds     Hybrid Journal   (Followers: 9)
Chemistry-Didactics-Ecology-Metrology     Open Access  
ChemistryOpen     Open Access   (Followers: 2)
Chemkon - Chemie Konkret, Forum Fuer Unterricht Und Didaktik     Hybrid Journal  
Chemoecology     Hybrid Journal   (Followers: 2)
Chemometrics and Intelligent Laboratory Systems     Hybrid Journal   (Followers: 15)
Chemosensors     Open Access  
ChemPhysChem     Hybrid Journal   (Followers: 8)
ChemPlusChem     Hybrid Journal   (Followers: 2)
ChemTexts     Hybrid Journal  
CHIMIA International Journal for Chemistry     Full-text available via subscription   (Followers: 2)
Chinese Journal of Chemistry     Hybrid Journal   (Followers: 6)
Chinese Journal of Polymer Science     Hybrid Journal   (Followers: 10)
Chromatographia     Hybrid Journal   (Followers: 23)
Chromatography Research International     Open Access   (Followers: 7)
Clay Minerals     Full-text available via subscription   (Followers: 9)
Cogent Chemistry     Open Access  
Colloid and Interface Science Communications     Open Access  
Colloid and Polymer Science     Hybrid Journal   (Followers: 10)
Colloids and Surfaces B: Biointerfaces     Hybrid Journal   (Followers: 8)
Combinatorial Chemistry & High Throughput Screening     Hybrid Journal   (Followers: 3)
Combustion Science and Technology     Hybrid Journal   (Followers: 18)
Comments on Inorganic Chemistry: A Journal of Critical Discussion of the Current Literature     Hybrid Journal   (Followers: 2)
Composite Interfaces     Hybrid Journal   (Followers: 6)
Comprehensive Chemical Kinetics     Full-text available via subscription   (Followers: 2)
Comptes Rendus Chimie     Full-text available via subscription  
Comptes Rendus Physique     Full-text available via subscription   (Followers: 1)
Computational and Theoretical Chemistry     Hybrid Journal   (Followers: 9)
Computational Biology and Chemistry     Hybrid Journal   (Followers: 12)
Computational Chemistry     Open Access   (Followers: 2)
Computers & Chemical Engineering     Hybrid Journal   (Followers: 9)
Coordination Chemistry Reviews     Full-text available via subscription   (Followers: 2)
Copernican Letters     Open Access  
Critical Reviews in Biochemistry and Molecular Biology     Hybrid Journal   (Followers: 5)
Crystal Structure Theory and Applications     Open Access   (Followers: 3)
CrystEngComm     Full-text available via subscription   (Followers: 10)
Current Catalysis     Hybrid Journal   (Followers: 2)
Current Metabolomics     Hybrid Journal   (Followers: 4)
Current Opinion in Colloid & Interface Science     Hybrid Journal   (Followers: 9)
Current Research in Chemistry     Open Access   (Followers: 8)
Current Science     Open Access   (Followers: 48)
Dalton Transactions     Full-text available via subscription   (Followers: 18)
Detection     Open Access   (Followers: 2)
Developments in Geochemistry     Full-text available via subscription   (Followers: 2)
Diamond and Related Materials     Hybrid Journal   (Followers: 11)
Dislocations in Solids     Full-text available via subscription  
Doklady Chemistry     Hybrid Journal  
Drying Technology: An International Journal     Hybrid Journal   (Followers: 3)
Eclética Química     Open Access   (Followers: 1)
Ecological Chemistry and Engineering S     Open Access   (Followers: 4)
Ecotoxicology and Environmental Contamination     Open Access  
Educación Química     Open Access   (Followers: 1)
Education for Chemical Engineers     Hybrid Journal   (Followers: 5)
EJNMMI Radiopharmacy and Chemistry     Open Access  
Elements     Full-text available via subscription   (Followers: 2)
Environmental Chemistry     Hybrid Journal   (Followers: 8)
Environmental Chemistry Letters     Hybrid Journal   (Followers: 4)
Environmental Science & Technology Letters     Full-text available via subscription   (Followers: 5)
Environmental Science : Nano     Partially Free   (Followers: 1)
Environmental Toxicology & Chemistry     Hybrid Journal   (Followers: 19)

        1 2 3 | Last

Journal Cover BioNanoScience
  [SJR: 0.428]   [H-I: 10]   [4 followers]  Follow
   Partially Free Journal Partially Free Journal
   ISSN (Print) 2191-1630 - ISSN (Online) 2191-1649
   Published by Springer-Verlag Homepage  [2329 journals]
  • Common Causes of Vertigo and Dizziness in Different Age Groups of Patients
    • Authors: M. V. Zamergrad; V. A. Parfenov; N. N. Yakhno; O. A. Melnikov; L. M. Antonenko; L. V. Nefedovskaya; N. V. Lebedeva
      Pages: 259 - 262
      Abstract: Abstract Dizziness and vertigo are among the most common symptoms occurring in clinical practice. However, the data on the main causes of dizziness and vertigo remain contradictory. We have analyzed the causes of dizziness in 590 outpatients who were referred to the neurologist. The most common causes of vertigo and dizziness in outpatient practice were benign paroxysmal positional vertigo (BPPV) (33.9 %), phobic postural vertigo (PPV) (21.4 %), Ménière’s disease/delayed endolymphatic hydrops (20 %), vestibular neuronitis/labyrinthitis (8.1 %), and vestibular migraine (4.1 %). Stroke as a cause of vertigo or dizziness was diagnosed only in 0.8 % of patients. Peripheral vestibular disorders were the most frequent cause of vertigo and dizziness in all age groups of patients: in patients younger than 45 years they were diagnosed in 57 % and in patients older than 60 years in 63.3 % of cases. PPV was the second most common cause of dizziness in patients younger than 45 years (37.4 %) but was established only in 7.6 % of patients older than 60 years. Most of the causes of vertigo and dizziness can be reliably diagnosed with bedside examination while laboratory investigation can be considered as an important but complementary entity.
      PubDate: 2017-06-01
      DOI: 10.1007/s12668-016-0351-5
      Issue No: Vol. 7, No. 2 (2017)
  • In Vitro Recombinant Expression of Novel Protective Protein Highly
           Accumulated in Dry State in an Anhydrobiotic Insect
    • Authors: Hagiwara-Komoda Yuka; Oleg Gusev; Elena Shagimardanova; Takahiro Kikawada
      Pages: 263 - 264
      Abstract: Abstract Recent intensive studies showed that ability of several groups of organisms to withstand complete desiccation (anhydrobiosis state) is largely based on the activity of several groups of key proteins, including representatives of intrinsically disordered ones. In the largest known anhydrobiotic animal, the sleeping chironomid, both proteomic and genome-wide/targeted mRNA expression analysis suggest that several groups of the novel proteins greatly contribute to the formation of the molecular shield. Among them, 114 aa-long protein, dryporin. Being one of the most abundant in the desiccated larvae on protein level and showing one of the highest expression on mRNA level, this protein shows lack of the obvious homology with other known proteins. In this study, we successfully produced recombinant dryporin protein using BY-2 cell free lysate and showed the evidence of post-translational modification of the protein in the anhydrobiotic larvae.
      PubDate: 2017-06-01
      DOI: 10.1007/s12668-016-0356-0
      Issue No: Vol. 7, No. 2 (2017)
  • Myogenic Trigger Zone of Trapezius Muscle Increases the Tone of the Middle
           Cerebral Artery
    • Authors: Oleg Esin; Radiy Esin; Ilshat Khairullin
      Pages: 300 - 301
      Abstract: Abstract A myogenic trigger zone (MTZ) has been shown to affect the tone of the surface arteries of the head and lower limbs. However, it remains largely unknown whether the tone of the intracranial arteries is regulated by MTZ. The aim of the present study was to investigate the effect of MTZ in trapezius muscle on the tone of the middle cerebral artery. Using ultrasound measurements of the peak velocity of blood flow and the Lindegaard index (LI), we found that the presence of an active MTZ in a trapezius muscle was per se associated with an increased LI values and that pressure stimulation of the MTZ further increases LI. When MTZ was eliminated by means of manual therapy, the indices of blood flow and LI returned to normal values. We conclude that the reflex spasm of the middle cerebral artery can occur in the presence of an active MTZ-TM and that this phenomenon contributes to the pathogenesis and the clinical symptoms associated with the cervicogenic and tension headaches.
      PubDate: 2017-06-01
      DOI: 10.1007/s12668-016-0344-4
      Issue No: Vol. 7, No. 2 (2017)
  • Liver Cells Proliferation and Apoptosis in Patients with Alcoholic Liver
           Disease After Autologous Hematopoietic Stem Cell Transplantation
    • Authors: Guzel Burganova; Sayar Abdulkhakov; Ilnaz Gazizov; Anisa Gumerova; Marina Titova; Alfiya Odintcova; Andrey Kiassov
      Pages: 302 - 305
      Abstract: Abstract Alcoholic liver disease is a huge medical and social problem that leads to liver fibrosis, cirrhosis, and hepatocellular carcinoma. Unfortunately, the last stages of the disease do not have efficient treatment, except liver transplantation, and require development of new therapeutical approaches. Transplantation of stem cells might be the most promising approach. In our research, we studied transplantation of autologous hematopoietic stem cells (HSC) into the celiac trunk of patients with alcoholic liver cirrhosis. In this article, we pay particular attention to proliferation and apoptosis—two fundamental processes, which determine the fate of regeneration. Liver biopsy specimens before treatment, 3 and 12 months after transplantation of HSC, were stained immunohistochemically with antibodies against PCNA and Bcl-2. The results showed that treatment was safe and effective, hepatocytes increased proliferation, and inflammatory cells decreased antiapoptotic activity, signifying improvement in liver regeneration. However, effect of treatment after 12 months decreases and requires repeated HSC transplantation.
      PubDate: 2017-06-01
      DOI: 10.1007/s12668-016-0354-2
      Issue No: Vol. 7, No. 2 (2017)
  • Genetic Characterization of Small (s)-Segment Genome Puumala Virus Strain
    • Authors: E. Kabwe; N. Y. Davidyuk; S. P. Morzunov; V. G. Shakirova; V. A Anokhin; G. S. Isaeva; R. K. Ismagilova; S. F. Khaiboullina; A. A. Rizvanov
      Pages: 316 - 319
      Abstract: Abstract The Republic of Tatarstan is one of the most active endemic regions for nephropathia epidemica (NE) in the Russian Federation. Annually, over 1000 cases of NE are registered, with an average mortality rate of 0.43 %. NE is a zoonosis where human become infected by inhaling a hantavirus-contaminated aerosol. Puumala virus is commonly detected in NE cases. Although NE cases have been registered in the region since 1958, little is known about the genetic variability of Puumala virus circulating in Tatarstan. We conducted phylogenetic analysis of the full length (1828 nt) small (S) segment genome sequence of Puumala virus RNA isolated from four bank voles (Myodes glareolus) captured during the 2014 outbreak. These virus sequences were compared to known sequences of Puumala viruses from nearby regions such as Samara and the Republic of Bashkortostan, as well as to European isolates. We found that there was over 89 % nucleotide identity between Puumala virus sequences isolated from the bank voles captured in Tatarstan. Sequence identity between Puumala viruses from the Tatarstan bank voles and the sequences from Republic of Bashkortostan and the Samara region were 90–95 %. Less similarity was found between Tatarstan sequences and Puumala strains circulating in Europe (79.7–87.7 %). Taken together, these data suggest that Puumala viruses circulating within the bank vole population in the Republic of Tatarstan are phylogenetically closer to the viruses circulating in neighboring regions of Russia.
      PubDate: 2017-06-01
      DOI: 10.1007/s12668-016-0338-2
      Issue No: Vol. 7, No. 2 (2017)
  • Improved Recordings of the Optical Intrinsic Signals in the Neonatal Rat
           Barrel Cortex
    • Authors: M. Sintsov; D. Suchkov; R. Khazipov; M. Minlebaev
      Pages: 333 - 337
      Abstract: Abstract Optical imaging of intrinsic signals (OIS) is widely used for the functional cortical mapping in vivo. Recently, OIS is also implemented for the functional mapping in the neonatal rat barrel cortex. However, the OIS is characterized by relatively low signal to noise ratio (SNR). Here, we determined parameters for post hoc data analysis that allowed improving OIS mapping and analysis in the developing rat barrel cortex in vivo. We found that application of spatial Gaussian filtering with sigma of 1 px increases the OIS SNR almost twofold. Additional light correction and low-pass temporal filtering with 1 s window size resulted in further improvement of the OIS SNR. Thus, the proposed digital filtering can substantially improve quality of the OIS recordings in the developing somatosensory cortex.
      PubDate: 2017-06-01
      DOI: 10.1007/s12668-016-0359-x
      Issue No: Vol. 7, No. 2 (2017)
  • Pharmacological Correction of Hypoxic Conditions by Complexes of Zinc with
    • Authors: S. A. Shakhmardanova; M. L. Maximov; L. N. Parshina; B. A. Trofimov; V. V. Tarasov; V. N. Chubarev; S. S. Arkhipova; S. S. Sologova
      Pages: 338 - 339
      Abstract: Abstract The discovery and development of effective antihypoxic drugs is an important issue in modern experimental and clinical pharmacology. Complexes of zinc containing imidazole cycles as ligands are promising candidates for the design of novel drugs, including pharmacotherapeutic tools for patient’s protection under conditions of oxygen deficiency. Herein, we report antihypoxic activity of zinc complexes with N-alkenylimidazoles, and, specifically, a novel drug Acyzol, which can be used as efficient antidote after poisoning by carbon monoxide and other combustion products.
      PubDate: 2017-06-01
      DOI: 10.1007/s12668-016-0322-x
      Issue No: Vol. 7, No. 2 (2017)
  • Effect of Solid Dispersions on the Dissolution of Ampicillin
    • Authors: I. I. Krasnyuk; A. V. Beliatskaya; I. I. Krasnyuk; O. I. Stepanova; L. A. Korol; A. M. Valeeva; V. V. Grikh; L. V. Ovsyannikova; T. M. Kosheleva
      Pages: 340 - 344
      Abstract: Abstract In this work, we studied water solubility of ampicillin trihydrate and its solid dispersions (SD) with polyethylene glycol-1500, polyvinylpyrrolidone-10000, and β-cyclodextrin. It was found that SD formation increases the solubility by a factor of 1.34–1.73 and the rate of ampicillin dissolution by a factor of 3.43–7.40. The results of complex physicochemical studies suggest that the improved release of ampicillin from SD is due to its micronization and solubilization by the polymer.
      PubDate: 2017-06-01
      DOI: 10.1007/s12668-016-0342-6
      Issue No: Vol. 7, No. 2 (2017)
  • Selective Extracellular Stimulation of Pharmacologically Distinct CCK/CB1R
           Positive Interneuron to Pyramidal Cell Perisomatic Inhibitory Synapses
    • Authors: Fliza Valiullina; David Jappy; Andrei Rozov
      Pages: 345 - 348
      Abstract: Abstract During prolonged whole cell recording, the intracellular contents are progressively dialyzed with the pipette solution; this often leads to significant changes in synaptic efficacy. To overcome this problem, we developed an approach allowing reliable extracellular stimulation of perisomatic synapses formed by CCK+/CB1+ interneurons onto CA1 pyramidal cells. Functional identification of this input was based on the unique features of CCK+/CB1+ terminals: long-lasting asynchronous transmitter release following high-frequency stimulation and exclusive expression of CB1R. Asynchronous release was used as an indication of proper positioning of the theta glass stimulation pipettes. We found that all extracellularly stimulated inputs with characteristic asynchronous release undergo robust DSI in response to 5-s depolarization and could also be almost entirely blocked by application of the CB1R agonist CP55940, which were similar to the data obtained with paired recordings from connected CB1+ and CA1 pyramidal cells. Thus, we have developed an approach allowing the selective and reliable extracellular stimulation of a subtype of hippocampal perisomatic inhibitory synapses.
      PubDate: 2017-06-01
      DOI: 10.1007/s12668-016-0310-1
      Issue No: Vol. 7, No. 2 (2017)
  • Population Dynamics of MafA-Positive Cells During Ontogeny of Human
    • Authors: Maxim Kaligin; Aleksandra Pliushkina; Angelina Titova; Marina Titova; Anisa Gumerova; Andrei Kiassov
      Pages: 352 - 359
      Abstract: Abstract Diverse transcription factors influencing cell differentiation are often chosen as markers of β cell progenitors. One of these transcription factors is MafA, which according to data in literature activates the expression of insulin gene in β cells. Other data support the hypothesis that MafA is required solely for the regulation of insulin secretion by β cells of adult islets and is not involved in the development of islet cells. In this paper, we study the role of MafA through both examination of human pancreas ontogeny and comparison of these data with dynamic changes in the population of insulin-positive and glucagon-positive cells. The aim of this research was the immunohistochemical analysis of MafA, insulin, and glucagon expression during human pancreas ontogeny. The research was conducted on whole embryos and isolated human fetal organs, obtained as a result of either miscarriage or legal medical abortion with voluntary consent of patients, and also on autopsy material from infant and adult human pancreas. As a result of this study, it was found that, during the ontogeny of human pancreas, the first MafA-positive cells appear in the islets at 12.5 weeks of gestation, that is, later than both insulin-positive cells (11.5 weeks of gestation) and glucagon-positive cells (8.5 weeks of gestation). No MafA-positive cells were found in the epithelium of pancreatic ducts. The number of MafA-positive cells in the islets increases during pancreatic organogenesis. The results of our research do not allow us to regard MafA as a marker of undifferentiated progenitors of islet cells. Based on this, we believe that the results obtained in this study are a supplementary contribution to the hypothesis that relates MafA to the markers of adult β cells.
      PubDate: 2017-06-01
      DOI: 10.1007/s12668-016-0369-8
      Issue No: Vol. 7, No. 2 (2017)
  • The Nature of Regulatory Autoantibody Changes Among Pregnant Women with
           Intrauterine Growth Restriction
    • Authors: R. S. Zamaleeva; N. A. Cherepanova; A. V. Frizina; N. Y. Chistiakova
      Pages: 373 - 375
      Abstract: Abstract Anenzyme-linked immunosorbent assay known as ELI-TEST was applied in 388 pregnant women in the gestational complication risk group who were 11– 4 weeks into pregnancy for the purpose of determining the serum content of Ig G class/that bind to double-stranded DNA, β2-glycoprotein I (β2 GP), total phospholipids (TFL), HCG vasculopathy markers (ANCA), collagen (Coll), PAPP-A, and insulin (Ins). After standardizing groups, 80 pregnant women with intrauterine growth restriction (IUGR) were selected for analysis. Characteristic changes in the levels of autoantibodies accompanying IUGR of varying severity were identified which not only gives a more accurate understanding of the pathogenesis of the disease but also enables one to define IUGR risk groups in the early stages of pregnancy.
      PubDate: 2017-06-01
      DOI: 10.1007/s12668-016-0365-z
      Issue No: Vol. 7, No. 2 (2017)
  • The Effects of Fluoxetine on Sensory-Evoked Responses in the Neonatal Rat
           Barrel Cortex
    • Authors: Daria Vinokurova; Andrey Zakharov; Dinara Akhmetshina; Azat Nasretdinov; Guzel Valeeva; Roustem Khazipov
      Pages: 378 - 381
      Abstract: Abstract Inhibition of serotonin uptake disrupts the development of thalamocortical barrel maps in neonatal rodents. Previous studies, using the selective serotonin reuptake inhibitor citalopram, have suggested that this may involve a suppression of the early activity in the developing cortex. Here, we addressed the acute effects of another frequently used serotonin uptake inhibitor, fluoxetine (10–120 mg/kg, intraperitoneally), on the sensory-evoked electrical responses in the neonatal (postnatal days P2-6) rat barrel cortex. We found that the administration of fluoxetine minimally affected the sensory-evoked responses in the rat pups. Two hours after the fluoxetine administration, there was a slight increase in the sensory-evoked potential (SEP) onset latency. There also was a tendency of SEP’s amplitude to decrease, but this was not significant. Fluoxetine also had no significant effect on the multiple unit activity during the SEP and sensory-evoked bursts and neither did it affect the spontaneous multiple unit activity. We suggest that the inhibitory effects of fluoxetine on the activity in the neonatal rat barrel cortex are much weaker, or that they develop over a slower time scale, than those evoked by citalopram, probably reflecting a lower potency of fluoxetine to inhibit the serotonin uptake.
      PubDate: 2017-06-01
      DOI: 10.1007/s12668-016-0370-2
      Issue No: Vol. 7, No. 2 (2017)
  • Hospitalized Patient Monitoring and Early Treatment Using IoT and Cloud
    • Authors: Salvatore Distefano; Dario Bruneo; Francesco Longo; Giovanni Merlino; Antonio Puliafito
      Pages: 382 - 385
      Abstract: Abstract The adoption of Internet of Things devices and, more in general, embedded systems, endowed with sensors and actuators, keeps rising globally, and the scope of their involvement broadens, for instance in e-Health applications. This work describes our integration of IoT paradigms and resource ecosystems with a tailored Cloud-oriented device-centric environment, by focusing on an e-Health scenario, featuring monitoring and early treatment of hospitalized patients, by focusing on Cloud-enabled event detection coupled with coordinated reaction.
      PubDate: 2017-06-01
      DOI: 10.1007/s12668-016-0335-5
      Issue No: Vol. 7, No. 2 (2017)
  • Role of Acetylcholinesterase in β-Amyloid Aggregation Studied by
           Accelerated Molecular Dynamics
    • Authors: Sofya V. Lushchekina; Ekaterina D. Kots; Dana A. Novichkova; Konstantin A. Petrov; Patrick Masson
      Pages: 396 - 402
      Abstract: Abstract Mechanisms of Alzheimer’s disease development are still under investigation. It was shown that acetylcholinesterase promotes aggregation of β-amyloid. Accelerated molecular dynamics simulations were performed to investigate molecular mechanisms of this process. Results showed that Aβ is strongly attracted to the surface of acetylcholinesterase and forms stable complexes. It was hypothesized that acetylcholinesterase serves as a nucleation center for propagation of β-amyloid aggregation.
      PubDate: 2017-06-01
      DOI: 10.1007/s12668-016-0375-x
      Issue No: Vol. 7, No. 2 (2017)
  • Programming Tools for Messenger-Based Chatbot System Organization:
           Implication for Outpatient and Translational Medicines
    • Authors: Almir Abashev; Ruslan Grigoryev; Karen Grigorian; Vladislav Boyko
      Pages: 403 - 407
      Abstract: Abstract The implementation of translational medicine is associated with considerable costs of equipment, staff competence, and doctor-patient (DP) and clinic-patient (CP) communication. The application of DP and CP systems evolved from e-mail letters to website assistance chat and smartphone apps in the context of the m-health paradigm. The rapid development of mobile messengers and chatbot systems has opened a new niche for DP and CP communication, providing a high population penetration rate with perfect capabilities for personalization. This article provides a model of chatbot system organization as well as programming tools for its implementation. The integration of machine conversation systems supplemented by natural spoken language together with m-health devices and mobile apps is a good solution for a variety of tasks in translational and outpatient medicine. The usage of chatbot systems as a communication device for the purposes of translational medicine is going to reduce costs and time on routine operations.
      PubDate: 2017-06-01
      DOI: 10.1007/s12668-016-0376-9
      Issue No: Vol. 7, No. 2 (2017)
  • Cytokine Levels in the Serum of Patients with Chronic Kidney Insufficiency
           Before and After Hemodialysis
    • Authors: Y. D. Romanova; M. I. Markelova; A. V. Laikov; L. I. Fakhrutdinova; M. I. Hasanova; S. Yu. Malanin; V. M. Chernov; I. I. Salafutdinov; S. F. Khaiboullina
      Pages: 415 - 418
      Abstract: Abstract Chronic kidney insufficiency (CKI) is often the end point of a broad range of chronic kidney diseases and characterized with decreasing number of functionally active nephrons. Pathophysiological CKI is characterized by decreased glomerular filtration, which leads to accumulation of life-threatening toxic metabolites. Hemodialysis is the main therapeutic measure aimed to prolong patient’s life until kidney transplant is available. The goal of this study is to analyze serum level of 21 cytokines in CKI. We have found that the serum level of several (IL-2Rα, IL-3, IL-12 (p40), IL-16, IL-18, HGF, MIF, CSF-1, MCP-3, CXCL12, SCF, IFN-α2, LIF, β-NGF, and CXCL1) cytokines and chemokines was upregulated in CKI without hemodialysis as compared to controls (p = 0.005). Interestingly, serum cytokines were also upregulated in serum of CKI patients who received hemodialysis. Upregulated cytokines are associated with inflammation and activation of Th1 lymphocytes. We suggest that hemodialysis has limited effect on serum cytokine levels. It could be concluded that therapeutic effect of hemodialysis is not associated with removal of inflammatory cytokines from circulation. Further studies will help better define the underlying cause of an increased inflammation in CKI and identify the laboratory criteria for anti-inflammatory therapy.
      PubDate: 2017-06-01
      DOI: 10.1007/s12668-016-0379-6
      Issue No: Vol. 7, No. 2 (2017)
  • Experimental Basosquamous Carcinoma Model in Rats
    • Authors: E. S. Snarskaya; L. N. Pylev; A. A. Akhunzyanov; E. V. Kuznetсova
      Pages: 423 - 427
      Abstract: Abstract Previous studies have established that 7,12-dimethylbenz(a)anthracene (DMBA) can initiate skin tumorigenesis in conventional furred mouse models by acting on hair follicle stem cells. In this work, we have developed a simple and convenient rat model of basosquamous carcinoma (BSC) using DMBA-induced carcinogenesis in male specific pathogen free (SPF) Wistar rats with no additional tumor promoter agents. The results showed that topical application of 0.1% solution of DMBA in benzene in a volume of 40 μL twice a week produced skin tumors after 8–9 months. As a result, during the 11–12th months, we obtained 15 animals with BSCs, 22 with basal cell carcinomas (BCCs), and 3 with squamous cell carcinomas (SCCs). This chemically driven skin cancer model in Wistar rats can serve as a suitable alternative to the mouse skin cancer model and can be reliably replicated as demonstrated by the experiment.
      PubDate: 2017-06-01
      DOI: 10.1007/s12668-016-0380-0
      Issue No: Vol. 7, No. 2 (2017)
  • The Lower Limb Joint Pathology Affects the Functional State of the Thigh
           Muscle Neuromotor Apparatus
    • Authors: Alexander Eremeev; Anna Shulman; Ilgiz Shaykhutdinov; Anton Eremeev
      Pages: 431 - 433
      Abstract: Abstract Diseases of joints are often associated with the alterations in the function of the associated muscles. The pathophysiological mechanisms underlying these changes in the muscle functions are poorly understood, however. Here, we explored the alterations in the neuromotor status of the hip quadriceps muscles in the coxartrosis and gonartrosis patients using electrostimulation myography. We found elevated motor response and H-reflex thresholds and a decrease of their amplitudes in the coxarthrosis and gonarthrosis patients compared to the healthy subjects. While the alterations in the motor responses may result from the reduced blood supply of the joint and the femoral nerve, changes in H-reflex indicate an involvement of the nociceptive signals from the joint in the central mechanisms of the movement control. We suggest that reduced reflex excitability of the spinal cord motor neurons controlling the quadriceps muscle in the coxartrosis and gonartrosis patients involves the afferents from the flexors and/or presynaptic inhibition of the IA afferents.
      PubDate: 2017-06-01
      DOI: 10.1007/s12668-016-0382-y
      Issue No: Vol. 7, No. 2 (2017)
  • Personalized Health Tracking with Edge Computing Technologies
    • Authors: Salvatore Distefano; Dario Bruneo; Francesco Longo; Giovanni Merlino; Antonio Puliafito
      Pages: 439 - 441
      Abstract: Abstract The health monitoring component is the essential block, a pillar of several e-health systems. Plenty of health tracking applications and specific technologies such as smart devices, wearables, and data management systems are available. To be effective, promptly reacting to issues, a health monitoring service must ensure short delays in data sensing, collection, and processing activities. This is an open problem that distributed computing paradigms, such as Internet of Things (IoT), Cloud, and Edge computing, could address. The solution proposed in this paper is based on Stack4Things, an IoT-Cloud framework to manage edge nodes such as mobiles, smart objects, network devices, workstations, as a whole, a computing infrastructure allowing to provide resources on-demand, as services, to end users. Through Stack4Things facilities, the health tracking system can locate the closer computing resource to offload processing and thus reducing latency per the Edge computing paradigm.
      PubDate: 2017-06-01
      DOI: 10.1007/s12668-016-0388-5
      Issue No: Vol. 7, No. 2 (2017)
  • Modeling the Fear-Like State in Realistic Neural Network
    • Authors: Max Talanov; Alexander Toschev; Alexey Leukhin
      Abstract: Abstract This paper is dedicated to the hypothesis that the influence of mammalian emotional states could be translated taking in account neuromodulatory processes into the influence over computational process of modern computers. We have implemented the “fear-like” state based on the three-dimensional monoamines model of affects inherited from works of Hugo Lövheim.
      PubDate: 2017-03-08
      DOI: 10.1007/s12668-017-0401-7
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Heriot-Watt University
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