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  Subjects -> CHEMISTRY (Total: 881 journals)
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CHEMISTRY (616 journals)                  1 2 3 4 | Last

Showing 1 - 200 of 735 Journals sorted alphabetically
2D Materials     Hybrid Journal   (Followers: 14)
Accreditation and Quality Assurance: Journal for Quality, Comparability and Reliability in Chemical Measurement     Hybrid Journal   (Followers: 26)
ACS Catalysis     Hybrid Journal   (Followers: 43)
ACS Chemical Neuroscience     Hybrid Journal   (Followers: 21)
ACS Combinatorial Science     Hybrid Journal   (Followers: 23)
ACS Macro Letters     Hybrid Journal   (Followers: 25)
ACS Medicinal Chemistry Letters     Hybrid Journal   (Followers: 41)
ACS Nano     Hybrid Journal   (Followers: 280)
ACS Photonics     Hybrid Journal   (Followers: 14)
ACS Symposium Series     Full-text available via subscription  
ACS Synthetic Biology     Hybrid Journal   (Followers: 24)
Acta Chemica Iasi     Open Access   (Followers: 5)
Acta Chimica Slovaca     Open Access   (Followers: 2)
Acta Chimica Slovenica     Open Access   (Followers: 1)
Acta Chromatographica     Full-text available via subscription   (Followers: 9)
Acta Facultatis Medicae Naissensis     Open Access  
Acta Metallurgica Sinica (English Letters)     Hybrid Journal   (Followers: 7)
Acta Scientifica Naturalis     Open Access   (Followers: 3)
adhäsion KLEBEN & DICHTEN     Hybrid Journal   (Followers: 7)
Adhesion Adhesives & Sealants     Hybrid Journal   (Followers: 9)
Adsorption Science & Technology     Open Access   (Followers: 6)
Advanced Functional Materials     Hybrid Journal   (Followers: 57)
Advanced Science Focus     Free   (Followers: 5)
Advances in Chemical Engineering and Science     Open Access   (Followers: 67)
Advances in Chemical Science     Open Access   (Followers: 18)
Advances in Chemistry     Open Access   (Followers: 21)
Advances in Colloid and Interface Science     Full-text available via subscription   (Followers: 19)
Advances in Drug Research     Full-text available via subscription   (Followers: 24)
Advances in Environmental Chemistry     Open Access   (Followers: 5)
Advances in Enzyme Research     Open Access   (Followers: 10)
Advances in Fluorine Science     Full-text available via subscription   (Followers: 9)
Advances in Fuel Cells     Full-text available via subscription   (Followers: 16)
Advances in Heterocyclic Chemistry     Full-text available via subscription   (Followers: 11)
Advances in Materials Physics and Chemistry     Open Access   (Followers: 25)
Advances in Nanoparticles     Open Access   (Followers: 15)
Advances in Organometallic Chemistry     Full-text available via subscription   (Followers: 16)
Advances in Polymer Science     Hybrid Journal   (Followers: 44)
Advances in Protein Chemistry     Full-text available via subscription   (Followers: 18)
Advances in Protein Chemistry and Structural Biology     Full-text available via subscription   (Followers: 20)
Advances in Quantum Chemistry     Full-text available via subscription   (Followers: 6)
Advances in Science and Technology     Full-text available via subscription   (Followers: 12)
African Journal of Bacteriology Research     Open Access  
African Journal of Chemical Education     Open Access   (Followers: 3)
African Journal of Pure and Applied Chemistry     Open Access   (Followers: 7)
Agrokémia és Talajtan     Full-text available via subscription   (Followers: 2)
Al-Kimia : Jurnal Penelitian Sains Kimia     Open Access  
Alkaloids: Chemical and Biological Perspectives     Full-text available via subscription   (Followers: 2)
AMB Express     Open Access   (Followers: 1)
Ambix     Hybrid Journal   (Followers: 3)
American Journal of Biochemistry and Biotechnology     Open Access   (Followers: 65)
American Journal of Biochemistry and Molecular Biology     Open Access   (Followers: 20)
American Journal of Chemistry     Open Access   (Followers: 30)
American Journal of Plant Physiology     Open Access   (Followers: 11)
American Mineralogist     Hybrid Journal   (Followers: 15)
Analyst     Full-text available via subscription   (Followers: 38)
Angewandte Chemie     Hybrid Journal   (Followers: 169)
Angewandte Chemie International Edition     Hybrid Journal   (Followers: 243)
Annals of Clinical Chemistry and Laboratory Medicine     Open Access   (Followers: 5)
Annual Reports in Computational Chemistry     Full-text available via subscription   (Followers: 3)
Annual Reports Section A (Inorganic Chemistry)     Full-text available via subscription   (Followers: 4)
Annual Reports Section B (Organic Chemistry)     Full-text available via subscription   (Followers: 9)
Annual Review of Chemical and Biomolecular Engineering     Full-text available via subscription   (Followers: 12)
Annual Review of Food Science and Technology     Full-text available via subscription   (Followers: 13)
Anti-Infective Agents     Hybrid Journal   (Followers: 3)
Antiviral Chemistry and Chemotherapy     Hybrid Journal   (Followers: 2)
Applied Organometallic Chemistry     Hybrid Journal   (Followers: 9)
Applied Spectroscopy     Full-text available via subscription   (Followers: 23)
Applied Surface Science     Hybrid Journal   (Followers: 32)
Arabian Journal of Chemistry     Open Access   (Followers: 6)
ARKIVOC     Open Access   (Followers: 1)
Asian Journal of Biochemistry     Open Access   (Followers: 2)
Atomization and Sprays     Full-text available via subscription   (Followers: 4)
Australian Journal of Chemistry     Hybrid Journal   (Followers: 7)
Autophagy     Hybrid Journal   (Followers: 2)
Avances en Quimica     Open Access  
Biochemical Pharmacology     Hybrid Journal   (Followers: 10)
Biochemistry     Hybrid Journal   (Followers: 354)
Biochemistry Insights     Open Access   (Followers: 6)
Biochemistry Research International     Open Access   (Followers: 6)
BioChip Journal     Hybrid Journal  
Bioinorganic Chemistry and Applications     Open Access   (Followers: 10)
Bioinspired Materials     Open Access   (Followers: 5)
Biointerface Research in Applied Chemistry     Open Access   (Followers: 2)
Biointerphases     Open Access   (Followers: 1)
Biology, Medicine, & Natural Product Chemistry     Open Access   (Followers: 2)
Biomacromolecules     Hybrid Journal   (Followers: 21)
Biomass Conversion and Biorefinery     Partially Free   (Followers: 10)
Biomedical Chromatography     Hybrid Journal   (Followers: 7)
Biomolecular NMR Assignments     Hybrid Journal   (Followers: 3)
BioNanoScience     Partially Free   (Followers: 5)
Bioorganic & Medicinal Chemistry     Hybrid Journal   (Followers: 131)
Bioorganic & Medicinal Chemistry Letters     Hybrid Journal   (Followers: 86)
Bioorganic Chemistry     Hybrid Journal   (Followers: 10)
Biopolymers     Hybrid Journal   (Followers: 18)
Biosensors     Open Access   (Followers: 2)
Biotechnic and Histochemistry     Hybrid Journal   (Followers: 2)
Bitácora Digital     Open Access  
Boletin de la Sociedad Chilena de Quimica     Open Access  
Bulletin of the Chemical Society of Ethiopia     Open Access   (Followers: 1)
Bulletin of the Chemical Society of Japan     Full-text available via subscription   (Followers: 24)
Bulletin of the Korean Chemical Society     Hybrid Journal   (Followers: 1)
C - Journal of Carbon Research     Open Access   (Followers: 3)
Cakra Kimia (Indonesian E-Journal of Applied Chemistry)     Open Access  
Canadian Association of Radiologists Journal     Full-text available via subscription   (Followers: 2)
Canadian Journal of Chemistry     Hybrid Journal   (Followers: 10)
Canadian Mineralogist     Full-text available via subscription   (Followers: 6)
Carbohydrate Research     Hybrid Journal   (Followers: 26)
Carbon     Hybrid Journal   (Followers: 70)
Catalysis for Sustainable Energy     Open Access   (Followers: 8)
Catalysis Reviews: Science and Engineering     Hybrid Journal   (Followers: 7)
Catalysis Science and Technology     Free   (Followers: 8)
Catalysis Surveys from Asia     Hybrid Journal   (Followers: 3)
Catalysts     Open Access   (Followers: 10)
Cellulose     Hybrid Journal   (Followers: 7)
Cereal Chemistry     Full-text available via subscription   (Followers: 4)
ChemBioEng Reviews     Full-text available via subscription   (Followers: 1)
ChemCatChem     Hybrid Journal   (Followers: 8)
Chemical and Engineering News     Free   (Followers: 19)
Chemical Bulletin of Kazakh National University     Open Access  
Chemical Communications     Full-text available via subscription   (Followers: 74)
Chemical Engineering Research and Design     Hybrid Journal   (Followers: 26)
Chemical Research in Chinese Universities     Hybrid Journal   (Followers: 3)
Chemical Research in Toxicology     Hybrid Journal   (Followers: 22)
Chemical Reviews     Hybrid Journal   (Followers: 189)
Chemical Science     Open Access   (Followers: 25)
Chemical Technology     Open Access   (Followers: 26)
Chemical Vapor Deposition     Hybrid Journal   (Followers: 5)
Chemie in Unserer Zeit     Hybrid Journal   (Followers: 56)
Chemie-Ingenieur-Technik (Cit)     Hybrid Journal   (Followers: 24)
ChemInform     Hybrid Journal   (Followers: 8)
Chemistry & Biodiversity     Hybrid Journal   (Followers: 7)
Chemistry & Biology     Full-text available via subscription   (Followers: 32)
Chemistry & Industry     Hybrid Journal   (Followers: 7)
Chemistry - A European Journal     Hybrid Journal   (Followers: 158)
Chemistry - An Asian Journal     Hybrid Journal   (Followers: 16)
Chemistry and Materials Research     Open Access   (Followers: 21)
Chemistry Central Journal     Open Access   (Followers: 4)
Chemistry Education Research and Practice     Free   (Followers: 5)
Chemistry in Education     Open Access   (Followers: 9)
Chemistry International     Open Access   (Followers: 2)
Chemistry Letters     Full-text available via subscription   (Followers: 43)
Chemistry of Materials     Hybrid Journal   (Followers: 257)
Chemistry of Natural Compounds     Hybrid Journal   (Followers: 9)
Chemistry World     Full-text available via subscription   (Followers: 19)
Chemistry-Didactics-Ecology-Metrology     Open Access   (Followers: 1)
ChemistryOpen     Open Access   (Followers: 1)
Chemkon - Chemie Konkret, Forum Fuer Unterricht Und Didaktik     Hybrid Journal  
Chemoecology     Hybrid Journal   (Followers: 4)
Chemometrics and Intelligent Laboratory Systems     Hybrid Journal   (Followers: 14)
Chemosensors     Open Access  
ChemPhysChem     Hybrid Journal   (Followers: 12)
ChemPlusChem     Hybrid Journal   (Followers: 2)
ChemTexts     Hybrid Journal  
CHIMIA International Journal for Chemistry     Full-text available via subscription   (Followers: 2)
Chinese Journal of Chemistry     Hybrid Journal   (Followers: 6)
Chinese Journal of Polymer Science     Hybrid Journal   (Followers: 11)
Chromatographia     Hybrid Journal   (Followers: 24)
Chromatography     Open Access   (Followers: 2)
Chromatography Research International     Open Access   (Followers: 6)
Clay Minerals     Full-text available via subscription   (Followers: 10)
Cogent Chemistry     Open Access   (Followers: 1)
Colloid and Interface Science Communications     Open Access  
Colloid and Polymer Science     Hybrid Journal   (Followers: 11)
Colloids and Interfaces     Open Access  
Colloids and Surfaces B: Biointerfaces     Hybrid Journal   (Followers: 6)
Combinatorial Chemistry & High Throughput Screening     Hybrid Journal   (Followers: 4)
Combustion Science and Technology     Hybrid Journal   (Followers: 22)
Comments on Inorganic Chemistry: A Journal of Critical Discussion of the Current Literature     Hybrid Journal   (Followers: 2)
Communications Chemistry     Open Access  
Composite Interfaces     Hybrid Journal   (Followers: 7)
Comprehensive Chemical Kinetics     Full-text available via subscription   (Followers: 1)
Comptes Rendus Chimie     Full-text available via subscription  
Comptes Rendus Physique     Full-text available via subscription   (Followers: 1)
Computational and Theoretical Chemistry     Hybrid Journal   (Followers: 9)
Computational Biology and Chemistry     Hybrid Journal   (Followers: 12)
Computational Chemistry     Open Access   (Followers: 2)
Computers & Chemical Engineering     Hybrid Journal   (Followers: 10)
Coordination Chemistry Reviews     Full-text available via subscription   (Followers: 4)
Copernican Letters     Open Access   (Followers: 1)
Corrosion Series     Full-text available via subscription   (Followers: 6)
Critical Reviews in Biochemistry and Molecular Biology     Hybrid Journal   (Followers: 6)
Croatica Chemica Acta     Open Access  
Crystal Structure Theory and Applications     Open Access   (Followers: 4)
CrystEngComm     Full-text available via subscription   (Followers: 13)
Current Catalysis     Hybrid Journal   (Followers: 2)
Current Chromatography     Hybrid Journal  
Current Green Chemistry     Hybrid Journal  
Current Metabolomics     Hybrid Journal   (Followers: 5)
Current Microwave Chemistry     Hybrid Journal  
Current Opinion in Colloid & Interface Science     Hybrid Journal   (Followers: 9)
Current Opinion in Molecular Therapeutics     Full-text available via subscription   (Followers: 14)
Current Research in Chemistry     Open Access   (Followers: 8)
Current Science     Open Access   (Followers: 69)
Current Trends in Biotechnology and Chemical Research     Open Access   (Followers: 3)
Dalton Transactions     Full-text available via subscription   (Followers: 23)
Detection     Open Access   (Followers: 2)
Developments in Geochemistry     Full-text available via subscription   (Followers: 2)
Diamond and Related Materials     Hybrid Journal   (Followers: 12)
Dislocations in Solids     Full-text available via subscription  
Doklady Chemistry     Hybrid Journal  

        1 2 3 4 | Last

Journal Cover
Journal Prestige (SJR): 0.308
Citation Impact (citeScore): 1
Number of Followers: 5  
  Partially Free Journal Partially Free Journal
ISSN (Print) 2191-1630 - ISSN (Online) 2191-1649
Published by Springer-Verlag Homepage  [2348 journals]
  • Calcium Transient and Quantal Release in Mouse Neuromuscular Junction
           Under Extracellular Calcium Concentration Change
    • Authors: Dmitry V. Samigullin; Nikita V. Zhilyakov; Eduard F. Khaziev; Ellya A. Bukharaeva; Eugeny E. Nikolsky
      Abstract: In mouse neuromuscular junction, the amplitude of the presynaptic calcium (Ca2+) transient was measured and correlated with mediator release at different extracellular Ca2+ concentrations. Fluorescent calcium-sensitive dye Oregon Green 488 BAPTA 1 hexapotassium salt was used for Ca2+ transient registration. The quantal content of release was assessed by the amplitude of the endplate potentials (EPPs) and was measured using intracellular microelectrodes. The amplitude of the EPPs changed more significantly than the amplitude of the Ca2+ transient when the extracellular calcium concentration was changed. Linear approximation of the dependence of the quantal content on the amplitude of the Ca2+ transient on double logarithmic scale gave a slope showing that the biochemical cooperativity was 2.86. The obtained value is comparable with the data calculated earlier in the neuromuscular junction of the rat and other synapses using electrophysiological measurements. Our data suggest that the change of the Ca2+ transients recorded from the whole volume of the nerve terminal properly reflects the variation of calcium concentration responsible for the neurotransmitter release in active zone. Thus, analysis of the bulk Ca2+ transient can be used to evaluate the calcium entry into the nerve endings and compare it with the number of quanta released under different conditions.
      PubDate: 2018-08-10
      DOI: 10.1007/s12668-018-0558-8
  • Cytotoxic and Antitumor Activity of Liposomal Silibinin
    • Authors: Nataliya B. Feldman; Tatiana I. Gromovykh; Natalia E. Sedyakina; Ivan I. Krasnyuk; Sergey V. Lutsenko
      Abstract: The cytotoxic and antitumor effect of liposomal form of silibinin was studied. It was shown that the liposomal silibinin reveals more pronounced cytotoxic activity in vitro against HeLa (cervix carcinoma), HT1080 (fibrosarcoma), and MCF-7 (breast adenocarcinoma) human tumor cell lines compared with non-liposomal silibinin. In vivo experiments demonstrated a possibility of parenteral use of the liposomal form. It was demonstrated that intravenous administration of liposomal silibinin has a significant antitumor effect in vivo against murine adenocarcinoma of Ca 755 and leads to inhibition of tumor growth (53.6%) and an increase (49.4%) in the mean life span of experimental animals compared to untreated control and animals receiving non-liposomal forms (free silibinin and its mixture with lecithin) administered orally.
      PubDate: 2018-08-09
      DOI: 10.1007/s12668-018-0556-x
  • Immunologic Parallels: Infectious Burden and Markers of Atopic Response
    • Authors: Elena V. Agafonova; Lidiia V. Krestnikova; Alexandra V. Salmakova; Guzel Sh. Isaeva; Elvira V. Syrykh
      Abstract: The relationship between serological markers of infections and the atopic status of patients with allergy symptoms (rhinorrhea, nasal congestion, recurrent cough, asthma attacks, recurrent skin rashes combined with skin itching) and an increased total Ig E level was investigated. The determination of an infectious burden included screening for bacterial pathogens, protozoa, and helminths. All patients also had specific—food and inhalation—Ig E testing done. The relationship between the infectious burden and a specific atopic status is ambiguous—different pathogens have different types of effects such as opposite, synergistic, or no effect in mono-exposure. In addition, it has been shown that the pattern of pathogen influence on specific IgE response can vary in different age periods. This is due to both cumulative effects associated with a prolonged antigen burden and “switching” of the immune response that forms a hyperimmune IgE response as a protective phenomenon against helminths.
      PubDate: 2018-08-03
      DOI: 10.1007/s12668-018-0546-z
  • Oligodynamic Effect of Silver Nanoparticles: a Review
    • Authors: Parteek Prasher; Manjeet Singh; Harish Mudila
      Abstract: The advent, efficacy, followed by the undiscerning and unrestricted consumption of antibiotics resulted in undue evolution in microbes in the form of multidrug resistance eventually resulting in the cultivation of new challenges to develop the new-generation antimicrobial therapy. A critical need for the development of novel, broad-spectrum therapeutics has thus arrived. The Silver nanoparticles (AgNPs) over the last few years have gained immense reputation as the next-generation antibiotics owing to their broad-spectrum activity against the disease-causing microbes which has been also extended against the highly evolved MDR strains. Also known to support the synergistic effect in combination with various commercially used antibiotics, the potential of AgNPs could be extensively exploited to gradually replace the old-generation drugs that certainly have lost their tooth against the resistant microbes.
      PubDate: 2018-08-03
      DOI: 10.1007/s12668-018-0552-1
  • Green Synthesis of Silver Nanoparticles (AgNPs) from Lenzites betulina and
           the Potential Synergistic Effect of AgNP and Capping Biomolecules in
           Enhancing Antioxidant Activity
    • Authors: Marion Ryan C. Sytu; Drexel H. Camacho
      Abstract: Properties of silver nanoparticles (AgNPs) are influenced by interactions and molecular structure of capping agents that stabilize them. Green synthesis of AgNPs using Lenzites betulina, a macrofungus with antioxidant properties, should be possible allowing the active metabolites or biomolecules to be incorporated in AgNP as capping molecules. Using surface plasmon resonance (SPR), the synthesis of AgNP using the aqueous extract of L. betulina was optimized. The purified L.betulina-capped AgNPs were then characterized and its antioxidant activity was compared with the raw L. betulina extract. The L. betulina-capped AgNPs exhibited SPR peak characteristic of AgNPs. Morphological analyses showed non-uniform spherical AgNP with visible intertwining capping agents engulfing the nanomaterial. FT-IR spectra revealed amide, carboxylate, and hydroxyl absorptions, confirming the role of some organic compounds as capping molecules. Extraction and complexation of the capping agent with SDS showed characteristic electronic excitation of phenylalanine along with tryptophan and tyrosine residues, suggesting the proteinaceous or polypeptide nature of the capping agent. The L. betulina-capped AgNPs were relatively stable (zeta potential − 26.7 mV), and the antioxidant activity was significantly enhanced compared to the raw extract. This is the first demonstration of L. betulina mushrooms in synthesizing AgNPs, the investigation of the proteinaceous capping biomolecules, and the enhanced effect of L. betulina-capped AgNPs in promoting stable radical reduction. Graphical ᅟ
      PubDate: 2018-08-02
      DOI: 10.1007/s12668-018-0548-x
  • Extraction of Hydroxyapatite from Fish Bones and Its Application in Nickel
    • Authors: Seyed Mohammad Hossein Dabiri; Amir Ardalan Rezaie; Mehrnaz Moghimi; Hamidreza Rezaie
      Abstract: Precious materials obtained from biowaste have risen the attentions toward extracting and using these materials in various applications to address both economic and environmental demands. In the present study, we focused on the extraction of hydroxyapatite (HA) from fish bones through the thermal calcination method. The primary tests were carried out to characterize the fish bone-derived materials in terms of chemical composition, morphology, and viability. Therefore, series of characterizing tests including Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), and inductively coupled plasma (ICP) were carried out. Also, secondary electron microscopy equipped with energy-dispersive spectroscopy (EDS) was performed to determine morphology and elemental analysis of the obtained powder. Furthermore, the cell viability of fish bone-derived hydroxyapatite (FHA) along with its cell differentiation capability was evaluated by performing MTT and ALP assays and the results were compared with those of the commercial type of hydroxyapatite (CHA). The secondary phase of the current study relates to the capability of FHA and CHA on adsorbing nickel, as a model heavy metal, from aqueous solutions by performing bath adsorption experiments and considering initial concentration of nickel, adsorbent dosage, and contact time as the variables. In order to investigate kinetic model and adsorption mechanism, first-order, pseudo-second-order, and intraparticle diffusion kinetic models were used. Also, the equilibrium data were analyzed using Langmuir, Freundlich, and DKR adsorption isotherm models. The XRD and FT-IR results confirmed the successful extraction of HA from fish bones. Besides, ICP and EDS results revealed that the Ca/P ratio of FHA was higher than that of stoichiometric ratio (1.67). In addition, the MTT and ALP results indicated that FHA seemed to be a viable material for cell proliferation and differentiation. Besides, the adsorption outcomes indicated that FHA was sufficiently capable of adsorbing nickel. It was observed that the adsorption data were fitted well with pseudo-second-order and Langmuir isotherm models with maximum adsorption capacities of 50.25 and 48.78 mg g−1on FHA and CHA, respectively.
      PubDate: 2018-07-31
      DOI: 10.1007/s12668-018-0547-y
  • The Influence of Hindlimb Unloading on the Bone Tissue’s Structure
    • Authors: Tatyana Baltina; Oskar Sachenkov; Oleg Gerasimov; Maxim Baltin; Artur Fedyanin; Igor Lavrov
      Abstract: The results of numerous studies indicate interactions between antiortostatic support and bone’s tissue. It is known that mechanical, genetic, endocrine, and age-related factors can influence the bones at the same time. Nevertheless, the physiological and pathological mechanisms of interconnection between unloading hindlimb and bones are largely unclear. The purpose of this study is to evaluate the correlation between unloading hindlimb and changes in bone’s tissue. After unloading of the hindlimb during 14 days, femoral bones were collected in order to evaluate the weight, density, and geometrical bone parameters. Additionally, a test with a three-point bending and computed tomography scanning was carried out. Using computed tomography data, fabric tensor was built. From the assumption that the bone tissue is orthotropic (exists a maximum of three mutually orthogonal axes with different material properties), we performed this analysis. Orthotropic properties of the bone tissue were analyzed in assumption that the principal direction of the fabric tensor is coaxial with the axes of orthotropy of the material. It was found that the axes of orthotropy of the bone tissue in the cross section are mostly directed in tangent direction, and after hindlimb unloading, axes of orthotropy rotate 90° (became directed in radial direction). Anisotropy ratio in the cross section changes significantly. Meanwhile, Young’s modulus and ultimate strength decrease. It shows that unloading of the hindlimb aggravates quality of the bone tissue.
      PubDate: 2018-07-28
      DOI: 10.1007/s12668-018-0551-2
  • Influence of Standardized Extract Ginkgo biloba EGb761 ® Towards Quality
           of Life Indicators in Patients with Diabetes Mellitus Type 2
    • Authors: Radiy Esin; Oleg Esin; Ilshat Khayrullin
      Abstract: Cognitive impairment in patients with type 2 diabetes mellitus (DM-2) currently attracts a lot of attention due to their impact on quality of life and the effectiveness of treatment. The aim of research is to find the most effective medication which influences the cognitive functions positively. The research included 120 patients with average age of 61.22 ± 8.6 and average DM-2 duration of 10.84 ± 8.2 years. Mini Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA test), Trail Making Test (TMT), Parts A and B, Hospital Anxiety and Depression Scale (HADS), and The Short Form-36 (SF-36) were used. It was revealed that patients with DM type 2 had cognitive dysfunction generally presented by mild cognitive impairment. Patients with DM-2 have an early manifestation of cognitive impairment. After the initial estimation of indicators, all the patients were taking standardized extract Ginkgo biloba (EGb 761®) in the dose 240 mg a day for 6 months. Estimation of all the indicators after 3 and 6 months of treatment showed significant cognitive improvement. By matching the available experimental and clinical data, we can conclude that in the setting of DM-2 EGb 761®, by producing a positive effect towards various factors which results from insulin resistance of the brain, improves functions of the brain, which manifests in improvement of main QoL indicators in DM-2.
      PubDate: 2018-07-25
      DOI: 10.1007/s12668-018-0550-3
  • Gamma-Radiation Monitoring of Luminescent Porous Silicon for Tumor Imaging
    • Authors: V. V. Galushka; O. Ya. Belobrovaya; D. N. Bratashov; O. Yu. Kondrateva; V. P. Polyanskaya; V. I. Sidorov; I. T. Yagudin; D. V. Terin
      Abstract: Photoluminescent macroporous silicon is studied for tumor imaging application. Gamma-radiation is used for modification of morphology of pores and their size. It is shown by Raman and photoluminescence study that after the irradiation of gamma rays new nanocrystallites of smaller diameter in comparison to the initial porous silicon appeared.
      PubDate: 2018-07-22
      DOI: 10.1007/s12668-018-0544-1
  • Plant-Mediated Green Synthesis of Zinc Oxide Nanoparticles Using Swertia
           chirayita Leaf Extract, Characterization and Its Antibacterial Efficacy
           Against Some Common Pathogenic Bacteria
    • Authors: Syed Md Humayun Akhter; Zafar Mahmood; Shamim Ahmad; Faiz Mohammad
      Abstract: The use of plant materials for the green synthesis of zinc oxide nanoparticles has enormous applications in pharmaceuticals, biotechnological, and biological fields. In this paper, we report Swertia chirayita leaf extract-mediated green synthesis of zinc oxide nanoparticles (ZnONPs). Furthermore, the as-prepared ZnONPs were characterized by employing Fourier transform infrared spectroscopy (FTIR), x-ray diffraction (XRD), UV-visible spectroscopy (UV-VIS), high-resolution transmission electron microscopy (HR-TEM), scanning electron microscopy (SEM), and energy-dispersive x-ray spectroscopy (EDS). The antibacterial efficacy of green synthesized ZnONPs was investigated against Gram-positive (Staphylococcus aureus) as well as Gram-negative (Escherichia coli and Salmonella enterica) bacterial strains. The efficacy of Swertia chirayita-extracted ZnONPs were found to be effective against Gram-positive as well as Gram-negative bacterial strains, suggesting its plausible use in cases of resistant bacterial infections.
      PubDate: 2018-07-17
      DOI: 10.1007/s12668-018-0549-9
  • Fecal Transplantation Against Recurrent Clostridium difficile Infection
    • Authors: Amin Talebi Bezmin Abadi; Allison Wren; Sayar R. Abdulkhakov; Albert A. Rizvanov
      Abstract: Clostridium difficile is a spore-forming Gram-positive intestinal inhabitant of many asymptomatic and symptomatic individuals. In the past, it was thought to have a commensal relationship with us but recent research has cast doubt on this. C. difficile infection (CDI) is a major public health concern and is associated with a decrease in fecal microbial diversity. In addition, the disrupted gastroduodenal microbial ecosystem by first-line antibiotic therapy is a predisposing factor for bacterial overgrowth by C. difficile. Given its high prevalence and the increasing incidence of virulent C. difficile isolates worldwide, with concomitant increased mortality and morbidity, new interventions including fecal microbiota transplantation (FMT) are urgently needed. The main rationale for FMT is to rebalance the gut microbiota. Undoubtedly, FMT is safe and efficacious enough to recommend it to decision-makers in order to institute routine application in clinical practices.
      PubDate: 2018-07-09
      DOI: 10.1007/s12668-018-0545-0
  • Influence of Silver, Zinc Oxide and Copper Oxide Nanoparticles on the
           Cyanobacterium Calothrix elenkinii
    • Authors: Himanshu Mahawar; Radha Prasanna; Shashi Bala Singh; Lata Nain
      Abstract: An investigation was undertaken to compare the effect of different concentrations of three metal nanoparticles i.e. silver (Ag), zinc oxide (ZnO) and copper oxide (CuO), on a cyanobacterium Calothrix elenkinii. Chlorophyll accumulation in C. elenkinii acclimatised to Ag NPs after 1 week at concentrations of 0.1 and 0.5 mg L−1, while it reduced at 1.0 mg L−1. A similar trend was recorded with CuO NPs, in terms of protein content with incubation time. Nitrogen-fixing potential also showed a gradual increase with Ag NPs, up to concentrations of 0.2 mg L−1 during incubation of 1 week, but sharply decreased at 0.5 mg L−1 after 48 h. Both the nitrogen-fixing potential and protein content were stimulated in the presence of CuO NPs. ZnO NPs, in general, were not compatible with the growth and metabolic activities of this cyanobacterium. Microscopic studies revealed the aggregation of NPs on the surface of C. elenkinii filaments, resulting in distinct morphological changes, particularly enhanced hormogonia and akinete formation. It is envisaged that with the increase in incubation period, C. elenkinii acclimatised to counteract the effect of Ag and CuO NPs and utilise them for its growth. The adaptive strategies of this cyanobacterium make it an ideal model system for future nanotoxicological studies.
      PubDate: 2018-07-04
      DOI: 10.1007/s12668-018-0543-2
  • Amoxicillin Loaded Hollow Microparticles in the Treatment of Osteomyelitis
           Disease Using Single-Nozzle Electrospinning
    • Authors: Esra Altun; Mehmet Onur Aydogdu; Fatma Koc; Ozlem Kutlu; Devrim Gozuacik; Sevil Yucel; Oguzhan Gunduz
      Abstract: In this study, hollow microparticles were produced with polymethylsilsesquioxane/chitosan/bovine hydroxyapatite/hexagonal boron nitride (PCBB) polyblend using single-nozzle electrospinning method. Also, hollow microparticles are loaded with amoxicillin (AMX) and their drug delivery capabilities have been studied according to a treatment of osteomyelitis disease. The morphology, chemical groups, particle size, antimicrobial activity, and AMX drug release were systematically studied using scanning electron microscopy (SEM), optical microscopy, Fourier transformation infrared spectroscopy (FTIR), hollow microparticle size measurements, antimicrobial activity test, and UV spectroscopy. In vitro biocompatibility was analyzed with human bone osteosarcoma (U2OS) cell line. This present work can help in the design of a drug delivery platform for antimicrobial effect and bone repair at the same time for osteomyelitis disease treatment.
      PubDate: 2018-07-02
      DOI: 10.1007/s12668-018-0539-y
  • Antioxidant and Immune Effects of Water Soluble Polysaccharides Isolated
           from Cinnamomum verum Bark
    • Authors: Mehendi Goyal; Harloveleen Kaur; Maitri Bhandari; Albert A. Rizvanov; Svetlana F. Khaiboullina; Manoj Baranwal
      Abstract: Cinnamomum verum plant is widely used in traditional medicine to reduce inflammation. In the present study, water-soluble polysaccharides were isolated from Cinnamomum verum bark followed by sequential separation from four solvent extracts (hexane, dichloromethane, chloroform and methanol) and analysed for the presence of sugar, protein and different phytochemicals. Crude and purified ethyl acetate fractions of soluble polysaccharides were analysed in vitro using mouse leukemic macrophage (RAW 264.7) cell line and human peripheral blood mononuclear cells (PBMCs). Water-soluble (crude and ethyl acetate purified fractionation) polysaccharides contained glucose, whereas proteins and phytochemicals were absent. Water-soluble polysaccharide fraction had less antioxidant activity as compared to all four solvent extracts. Also, water-soluble polysaccharides (250 μg/ml) did not affect the cell growth, while all other four extracts (250 μg/ml) inhibited the growth of RAW 264.7 cells. Cell growth inhibition was detected when concentration of crude and ethyl acetate fraction polysaccharides was increased, where IC50 values were 1120 ± 27 and 1780 ± 227 μg/mL, respectively. Interestingly, crude and ethyl acetate polysaccharides showed concentration-dependent increase of the cell growth in PBMCs, indicating immunostimulating effect. Our data suggests that the immunological properties of cinnamon may be associated with the presence of polysaccharides.
      PubDate: 2018-06-29
      DOI: 10.1007/s12668-018-0542-3
  • Optimization of Chitosan-Gelatin Nanofibers Production: Investigating the
           Effect of Solution Properties and Working Parameters on Fibers Diameter
    • Authors: Nafise Amiri; Zohreh Rozbeh; Toktam Afrough; Sayyed Abolghasem Sajadi Tabassi; Ali Moradi; Jebrail Movaffagh
      Abstract: Electrospinning of chitosan-gelatin, using organic solvents, have already been reported. This study was designed to fabricate, characterize, and optimize electrospun chitosan-gelatin nanofibrous membranes using acetic acid as a more safe alternative aqueous solvent. Series of 90/10, 80/20, 70/30, 60/40, and 50/50 ratios of chitosan and gelatin were prepared using aqueous acetic acid as solvent. Blend solutions were electrospun after adding polyethylene oxide (PEO) to facilitate the electrospinning process. The effects of solution properties as well as the operating parameters on the architecture of the electrospun chitosan-gelatin nanofibers were investigated through evaluation of the electrical conductivity, viscosity, morphology, Fourier transform infrared spectroscopy (FTIR), mechanical properties, and hydrophilicity. Uniform beadless nanofibrous hydrophilic mats were fabricated with average fiber diameters from 229.79 ± 41.45 to 308.66 ± 50.03 nm. Concentration was the main parameter among all solution properties in controlling nanofiber diameter. The fiber diameters decreased with increasing the voltage, decreasing the feed rate, and increasing the needle to collector distance up to a certain amount. The interactions between the components of the blend solutions were confirmed by FTIR spectra. The Young’s moduli of all chitosan-gelatin blend nanofibers were higher than the chitosan nanofibers and increased significantly after cross-linking (P < 0.05). Chitosan-gelatin blends with different ratios of each biopolymer can be electrospun using acetic acid as an aqueous solvent and addition of PEO to yield hydrophilic membranes with uniform and beadless nanofibers. The architectural similarity of the nanofibrous chitosan-gelatin mats to natural ECM makes them great candidates for different biomedical applications.
      PubDate: 2018-06-25
      DOI: 10.1007/s12668-018-0540-5
  • Tuberous Sclerosis Complex: a Case Study
    • Authors: Rimma Gamirova
      Abstract: The article is a contribution to the international database of tuberous sclerosis case studies. As tuberous sclerosis complex (Bourneville–Pringle disease) is a rare genetically determined polysystemic disease, each clinical case is very significant. The first clinical symptoms of the disease usually appear immediately after birth, but they differ in significant polymorphism and affect brain, different organs, and systems, including changes in the skin, nervous system, eyes, and inner organs. Accurate diagnosis of tuberous sclerosis is fundamental to proper medical supervision and treatment. The article describes modern genetic and clinical criteria of diagnosis in detail; the specificity of the clinical case and problems emerged during follow-up of the patient, diagnostic errors, and findings. The author proves the importance of a multidisciplinary approach not only in diagnosis but also in the treatment of tuberous sclerosis including neuropsychological approaches.
      PubDate: 2018-06-22
      DOI: 10.1007/s12668-018-0541-4
  • Quantitative Cytotoxicity, Cellular Uptake and Radioprotection Effect of
           Cerium Oxide Nanoparticles in MRC-5 Normal Cells and MCF-7 Cancerous Cells
    • Authors: Nouraddin Abdi Goushbolagh; Bagher Farhood; Akram Astani; Abolfazl Nikfarjam; Mojgan Kalantari; Mohammad Hosein Zare
      Abstract: Optimal distribution of cerium oxide nanoparticles (CONPs) or nanoceria can have a significant impact on their cytotoxicity, cellular uptake, and radioprotection effects. In this study, two different distribution plans of CONPs were investigated. A scanner electron microscope (SEM) was used for chemical analysis and recording of CONP images. Using MTT assay, the non-toxic concentrations of nanoceria with two different distribution plans were determined in MRC-5 and MCF-7 cell lines. Nanoceria cellular uptake at 50, 150, and 250 μM with two different dispersion plans was determined by using the UV/VIS absorbance of cell culture medium after 24 h of incubation. In order to quantify radioprotection effect, cells treated with non-toxic concentrations of nanoceria were exposed to 10, 40, and 100 cGy of 6 MV photon beams. The diameter of the spherical CONPs was 29 nm. Energy dispersive spectroscopy analysis showed that the cerium element has the highest weight percentage in CONPs (97.9%). Accumulation rate of filtered and non-filtered suspension were determined as 0.3608 and 14.2708 μg/ml/h, respectively. The 70 and 110 μM concentration of sustained nanoceria suspension did not have any toxicity for MRC-5 and MCF-7 cells, respectively. In both cell lines, 50, 150, and 250 μM of filtered nanoceria had a significant uptake than the non-filtered nanoceria. A total of results showed that the 70 μM of nanoceria have a significant radioprotection on normal cells in the radiation dose of 40 and 100 cGy, while the highest cellular uptake of nanoceria occurred in cancer cells. The results suggest that using of stable distribution of CONPs for radiation protection could be a good choice, knowing that these nanostructures will have selective protection in normal cells.
      PubDate: 2018-06-18
      DOI: 10.1007/s12668-018-0538-z
  • Studying of Surfactant Excess Separation from Non-aqueous Quantum Dots
           Solution on its Monolayer Formation Process
    • Authors: Ammar J. Al-Alwani; K. I. Kosolapova; A. S. Chumakov; V. O. Lukyanova; I. A. Gorbachev; А. V. Kazak; А. I. Smirnova; S. N. Shtykov; N. V. Usol’tseva; E. G. Glukhovskoy
      Abstract: Controlled purification of non-aqueous solution of CdSe/CdS/ZnS quantum dots (QD) (dispersed in toluene or chloroform) from an excess of surfactant (oleic acid) was studied. The separation of unbound oleic acid from QD solution was carried out by using high-density polyethylene (HDPE) membrane. The secondary solution with a separated surfactant as well as initial QD solution was spread over the water surface to obtain a monolayer with its compression isotherms studied using Langmuir-Blodgett (LB) technique. This approach allowed us to determine the concentration of surfactant at a level of 10−5 mol/l or less for CdSe/CdS/ZnS QD. For better understanding of the influence of purification on the properties of QD, the monolayer of QD was transferred onto solid substrate and its morphology was studied. Atomic force microscopy showed that removal of oleic acid excess results in a more uniform and dense packing of quantum dots.
      PubDate: 2018-06-08
      DOI: 10.1007/s12668-018-0537-0
  • Integration of Photocatalytic Oxidation and Biodegradation Treatment
           Processes to Enhance Degradation Efficiency of CETP Wastewater
    • Abstract: In the present, experiment reported an emerging approach of integrated treatment processes such as photocatalytic oxidation and biodegradation to increase degradation efficiency of CETP wastewater. Photocatalytic oxidation process performed using hybrid photocatalyst Ti02 impregnated with activated carbon (AC) and biodegradation was performed by developed biofilm on biocarrier. Synthesized TiO2/AC powder was characterized by sophisticated instrumentation. A lab scale photocatalytic bioreactor was designed to remove pollutants from CETP effluent. In this setup, sample was treated with hybrid photocatalyst TiO2/AC under the sunlight and developed biofilm; sampling was done and analyzed. Our results show better degradation within 6 h because of generation of hydroxyl radical and superoxide species reacted with pollutants. This presented experiment shows the rapid degradation and increase removal efficiency of pollutants by using the integrated processes. Graphical ᅟ
      PubDate: 2018-06-07
      DOI: 10.1007/s12668-018-0534-3
  • Effects of Inclination of Micro-capillary on Blood-Viscosity of Diseased
           Blood in Presence of Metallic Ball
    • Abstract: Dynamic changes in rheology of blood within microvasculature structures can be used for diagnosing chronic non-communicable disease at earlier stages. Behavior of blood in microvascular structures (capillaries) is mysterious. In case of capillaries present in brain, such dynamic continuum induces hindrance to oxygen diffusion through circumvented nerve fibers at the junction of blood-brain barriers. It causes temporary regional hypoxia. Therefore, understanding the rheology of blood in micro-confined capillaries may evolve as a tool for early prediction of hypoxia. Viscosity of blood in micro-capillaries can be measured by principle of falling ball viscometer. But this technique produces inconsistent result for non-Newtonian fluid. In this paper, we have presented an investigation on dynamic behavior of blood rheology within micro-capillaries inclined at different degrees of inclinations. Experimental results are complemented with detailed numerical simulations. Experimental observations reveal significant variation of rheological parameters of blood in micro-capillaries. Inter-gender variations confirm the contribution of hematocrit in blood for this variation. The rheological parameters of blood with diseased condition are found to vary with the different degrees of inclination of the micro-capillary. Effect of rolling ball on the red blood cells (RBCs) during interaction in the capillary of the viscometer is found to induce deformative stress on membrane of RBC. It is also confirmed by the continuous sustainability of the higher magnitude strain rate near the wall (between boundaries of ball and wall). Inclined angle of capillary tube was also found as a parameter for defining rheology of blood in micro-capillary.
      PubDate: 2018-06-07
      DOI: 10.1007/s12668-018-0536-1
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