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CHEMISTRY (530 journals)                  1 2 3 4 5 6 | Last

2D Materials     Hybrid Journal  
Accreditation and Quality Assurance: Journal for Quality, Comparability and Reliability in Chemical Measurement     Hybrid Journal   (Followers: 32)
ACS Catalysis     Full-text available via subscription   (Followers: 23)
ACS Chemical Neuroscience     Full-text available via subscription   (Followers: 13)
ACS Combinatorial Science     Full-text available via subscription   (Followers: 7)
ACS Macro Letters     Full-text available via subscription   (Followers: 16)
ACS Medicinal Chemistry Letters     Full-text available via subscription   (Followers: 24)
ACS Nano     Full-text available via subscription   (Followers: 213)
ACS Photonics     Full-text available via subscription   (Followers: 2)
ACS Synthetic Biology     Full-text available via subscription   (Followers: 8)
Acta Chemica Iasi     Open Access  
Acta Chimica Slovaca     Open Access   (Followers: 5)
Acta Chromatographica     Full-text available via subscription   (Followers: 9)
Acta Facultatis Medicae Naissensis     Open Access   (Followers: 1)
Acta Metallurgica Sinica (English Letters)     Hybrid Journal   (Followers: 2)
adhäsion KLEBEN & DICHTEN     Hybrid Journal   (Followers: 2)
Adhesion Adhesives & Sealants     Hybrid Journal   (Followers: 4)
Adsorption Science & Technology     Full-text available via subscription   (Followers: 8)
Advanced Functional Materials     Hybrid Journal   (Followers: 31)
Advances in Chemical Engineering and Science     Open Access   (Followers: 21)
Advances in Chemical Science     Open Access   (Followers: 8)
Advances in Colloid and Interface Science     Full-text available via subscription   (Followers: 13)
Advances in Drug Research     Full-text available via subscription   (Followers: 16)
Advances in Fluorine Science     Full-text available via subscription   (Followers: 7)
Advances in Fuel Cells     Full-text available via subscription   (Followers: 12)
Advances in Heterocyclic Chemistry     Full-text available via subscription   (Followers: 8)
Advances in Materials Physics and Chemistry     Open Access   (Followers: 11)
Advances in Nanoparticles     Open Access   (Followers: 10)
Advances in Organometallic Chemistry     Full-text available via subscription   (Followers: 8)
Advances in Polymer Science     Hybrid Journal   (Followers: 38)
Advances in Protein Chemistry     Full-text available via subscription   (Followers: 6)
Advances in Protein Chemistry and Structural Biology     Full-text available via subscription   (Followers: 9)
Advances in Quantum Chemistry     Full-text available via subscription   (Followers: 4)
African Journal of Chemical Education     Open Access   (Followers: 1)
African Journal of Pure and Applied Chemistry     Open Access   (Followers: 1)
Afrique Science : Revue Internationale des Sciences et Technologie     Open Access  
Agrokémia és Talajtan     Full-text available via subscription   (Followers: 2)
Alchemy     Open Access   (Followers: 2)
Alkaloids: Chemical and Biological Perspectives     Full-text available via subscription   (Followers: 4)
AMB Express     Open Access   (Followers: 1)
Ambix     Hybrid Journal   (Followers: 3)
American Journal of Applied Sciences     Open Access   (Followers: 27)
American Journal of Biochemistry and Biotechnology     Open Access   (Followers: 127)
American Journal of Biochemistry and Molecular Biology     Open Access   (Followers: 11)
American Journal of Chemistry     Open Access   (Followers: 17)
American Journal of Plant Physiology     Open Access   (Followers: 9)
American Mineralogist     Full-text available via subscription   (Followers: 2)
Analyst     Full-text available via subscription   (Followers: 35)
Angewandte Chemie     Hybrid Journal   (Followers: 11)
Angewandte Chemie International Edition     Hybrid Journal   (Followers: 175)
Annales UMCS, Chemia     Open Access   (Followers: 2)
Annual Reports in Computational Chemistry     Full-text available via subscription   (Followers: 1)
Annual Reports Section A (Inorganic Chemistry)     Full-text available via subscription   (Followers: 2)
Annual Reports Section B (Organic Chemistry)     Full-text available via subscription   (Followers: 4)
Annual Review of Chemical and Biomolecular Engineering     Full-text available via subscription   (Followers: 9)
Annual Review of Food Science and Technology     Full-text available via subscription   (Followers: 11)
Anti-Infective Agents     Hybrid Journal   (Followers: 1)
Applied Organometallic Chemistry     Hybrid Journal   (Followers: 4)
Applied Spectroscopy     Full-text available via subscription   (Followers: 12)
Applied Surface Science     Hybrid Journal   (Followers: 14)
Arabian Journal of Chemistry     Full-text available via subscription   (Followers: 6)
ARKIVOC     Open Access   (Followers: 1)
Asian Journal of Biochemistry     Open Access   (Followers: 1)
Australian Journal of Chemistry     Hybrid Journal   (Followers: 4)
Autophagy     Full-text available via subscription  
Avances en Quimica     Open Access   (Followers: 1)
Biochemical Pharmacology     Hybrid Journal   (Followers: 6)
Biochemistry     Full-text available via subscription   (Followers: 163)
Biochemistry Insights     Open Access   (Followers: 4)
Biochemistry Research International     Open Access   (Followers: 4)
BioChip Journal     Hybrid Journal   (Followers: 1)
Bioinorganic Chemistry and Applications     Open Access   (Followers: 4)
Biointerface Research in Applied Chemistry     Open Access   (Followers: 1)
Biointerphases     Open Access  
Biomacromolecules     Full-text available via subscription   (Followers: 16)
Biomass Conversion and Biorefinery     Partially Free   (Followers: 5)
Biomedical Chromatography     Hybrid Journal   (Followers: 7)
Biomolecular NMR Assignments     Hybrid Journal   (Followers: 2)
BioNanoScience     Partially Free   (Followers: 4)
Bioorganic & Medicinal Chemistry     Hybrid Journal   (Followers: 30)
Bioorganic & Medicinal Chemistry Letters     Hybrid Journal   (Followers: 24)
Bioorganic Chemistry     Hybrid Journal   (Followers: 5)
Biopolymers     Hybrid Journal   (Followers: 12)
Biosensors     Open Access   (Followers: 3)
Biotechnic and Histochemistry     Hybrid Journal   (Followers: 1)
Boletin de la Sociedad Chilena de Quimica     Open Access  
Bulletin of the Chemical Society of Ethiopia     Open Access   (Followers: 1)
Bulletin of the Chemical Society of Japan     Full-text available via subscription   (Followers: 11)
Canadian Association of Radiologists Journal     Full-text available via subscription   (Followers: 3)
Canadian Journal of Chemistry     Full-text available via subscription   (Followers: 6)
Canadian Mineralogist     Full-text available via subscription   (Followers: 1)
Carbohydrate Research     Hybrid Journal   (Followers: 10)
Carbon     Hybrid Journal   (Followers: 34)
Catalysis for Sustainable Energy     Open Access   (Followers: 1)
Catalysis Reviews: Science and Engineering     Hybrid Journal   (Followers: 4)
Catalysis Science and Technology     Free   (Followers: 4)
Catalysis Surveys from Asia     Hybrid Journal   (Followers: 4)
Catalysts     Open Access   (Followers: 6)
Cellulose     Hybrid Journal   (Followers: 4)
Central European Journal of Chemistry     Hybrid Journal   (Followers: 5)

        1 2 3 4 5 6 | Last

Journal Cover Chemistry & Biodiversity
   [7 followers]  Follow    
   Hybrid Journal Hybrid journal (It can contain Open Access articles)
     ISSN (Print) 1612-1872 - ISSN (Online) 1612-1880
     Published by John Wiley and Sons Homepage  [1602 journals]   [SJR: 0.541]   [H-I: 35]
  • Contents: C&B 6/2014
    • Pages: n/a - n/a
      PubDate: 2014-06-17T03:17:03.403208-05:
      DOI: 10.1002/cbdv.201490006
  • Volatile Compounds of Viola odorata Absolutes: Identification of Odorant
           Active Markers to Distinguish Plants Originating from France and Egypt
    • Authors: Laure Saint-Lary; Céline Roy, Jean-Philippe Paris, Pascal Tournayre, Jean-Louis Berdagué, Olivier P. Thomas, Xavier Fernandez
      Pages: 843 - 860
      Abstract: Absolutes isolated from Viola odorata leaves, valuable materials for the flavor and fragrance industry, were studied. Violets are mainly cultivated in France and Egypt and extracted locally. The absolutes of the two origins showed different olfactory profiles both in top and heart notes, as evidenced by sensory analysis. The aims of this study were i) to characterize the volatile compounds, ii) to determine the odorant-active ones, and iii) to identify some markers of the plant origin. Two complementary analytical methods were used for these purposes, i.e., headspace solid-phase microextraction (HS-SPME) using different fiber coatings followed by GC/MS analysis and gas chromatography – olfactometry/mass spectrometry (GC-O/MS) applied to violet leaf extracts. From a total of 70 identified compounds, 61 have never been reported so far for this species, 17 compounds were characterized by both techniques (with seven among them known from the literature), 23 compounds were solely identified by HS-SPME GC/MS (among them only two being already mentioned as components of violet absolutes in the literature), and, finally, 30 compounds were only identified by GC-O/MS. According to the HS-SPME GC/MS analyses, ethyl hexanoate and (2E,6Z)-nona-2,6-dienol were specific volatile compounds of the sample with French origin, while (E,E)-hepta-2,4-dienal, hexanoic acid, limonene, tridecane, and eugenol were specific of the samples with Egyptian origin. Additional compounds that were not detected by HS-SPME GC/MS analysis were revealed by GC-O analyses, some of them being markers of origin. Pent-1-en-3-ol, 3-methylbut-2-enal, 2-methoxy-3-(1-methylethyl)pyrazine, 4-ethylbenzaldehyde, β-phenethyl formate, and 2-methoxy-3-(2-methylpropyl)pyrazine revealed to be odorant markers of the French sample, whereas cis-rose oxide, trans-rose oxide, and 3,5,5-trimethylcyclohex-2-enone were odorant markers of the Egyptian samples.
      PubDate: 2014-06-17T03:17:04.886183-05:
      DOI: 10.1002/cbdv.201300387
  • Binding Pockets and Permeation Channels for Dioxygen through Cofactorless
           3-Hydroxy-2-methylquinolin-4-one 2,4-Dioxygenase in Association with Its
           Natural Substrate, 3-Hydroxy-2-methylquinolin-4(1H)-one. A Perspective
           from Molecular Dynamics Simulations
    • Authors: Francesco Pietra
      Pages: 861 - 871
      Abstract: This work describes an investigation of pathways and binging pockets (BPs) for dioxygen (O2) through the cofactorless oxygenase 3-hydroxy-2-methylquinolin-4-one 2,4-dioxygenase in complex with its natural substrate, 3-hydroxy-2-methylquinolin-4(1H)-one, in aqueous solution. The investigation tool was random-acceleration molecular dynamics (RAMD), whereby a tiny, randomly oriented external force is applied to O2 in order to accelerate its movements. In doing that, care was taken that the external force only continues, if O2 moves along a direction for a given period of time, otherwise the force changed direction randomly. Gates for expulsion of O2 from the protein, which can also be taken as gates for O2 uptake, were found throughout almost the whole external surface of the protein, alongside a variety of BPs for O2. The most exploited gates and BPs were not found to correspond to the single gate and BP proposed previously from the examination of the static model from X-ray diffraction analysis of this system. Therefore, experimental investigations of this system that go beyond the static model are urgently needed.
      PubDate: 2014-06-17T03:17:06.694201-05:
      DOI: 10.1002/cbdv.201400054
  • Diarylheptanoids from Green Alder Bark and Their Potential for DNA
    • Authors: Miroslav Novaković; Miroslava Stanković, Ivan Vučković, Nina Todorović, Snežana Trifunović, Danijela Apostolović, Boris Mandić, Milan Veljić, Petar Marin, Vele Tešević, Vlatka Vajs, Slobodan Milosavljević
      Pages: 872 - 885
      Abstract: Nine diarylheptanoids, 1–9, catechin (11), and a phenolic glucoside, 10, were isolated from the bark of green alder (Alnus viridis). Four of the isolated compounds, i.e., 2, 5, 8, 10, are new. The structures of 1–11 were determined on the basis of spectroscopic data. All isolated compounds were evaluated for their in vitro protective effects on chromosome aberrations in peripheral human lymphocytes using cytokinesis-block micronucleus (CBMN) assay. Almost all of them exerted a pronounced effect of decreasing DNA damage of human lymphocytes, acting stronger than the known synthetic protector amifostine.
      PubDate: 2014-06-17T03:17:06.420757-05:
      DOI: 10.1002/cbdv.201300277
  • Semisynthesis and Antifungal Activity of Novel Oxime Ester Derivatives of
           Carabrone Modified at C(4) against Botrytis cinerea
    • Authors: Delong Wang; Shuangxi Ren, Hao Wang, He Yan, Juntao Feng, Xing Zhang
      Pages: 886 - 903
      Abstract: To continuously improve the potential utility of the natural lead compound of carabrone in agrochemistry, carabrone oxime and 36 novel oxime ester derivatives of carabrone modified at C(4) were synthesized, and evaluated for their antifungal activities against Botrytis cinerea in vitro and in vivo. Of these 36 oxime ester derivatives, some compounds exhibited antifungal activities in vitro or in vivo. It was found that compounds with a pyridinyl residue can either efficiently inhibit spore germination or efficiently inhibit hyphal growth of B. cinerea, and compound 9 exhibited the highest activity in vitro and in vivo with IC50 and EC50 values of 1.17 and 12.9 μg/ml, respectively. Further, the structureactivity relationships are also discussed.
      PubDate: 2014-06-17T03:17:04.513248-05:
      DOI: 10.1002/cbdv.201300212
  • Chloranthones A – D: Minor and Unprecedented Dinor-Eudesmenes from
           Chloranthus elatior
    • Authors: Shu-Ting Liu; Juan Xiong, Yu Tang, Wen-Xuan Wang, Van-Binh Bui, Guang-Lei Ma, Ya Huang, Yun Zhao, Guo-Xun Yang, Jin-Feng Hu
      Pages: 904 - 909
      Abstract: Four novel naturally occurring diastereoisomers of dinor-eudesmenes, named chloranthones A–D (1–4, resp.), were isolated as minor components from the EtOH extract of the aerial parts of Chloranthus elatior. The unprecedented framework was established using extensive 2D-NMR techniques. Their absolute configurations were deduced from the observed Cotton effects in their circular dichroism (CD) spectra. A plausible biosynthetic pathway to the dinor-eudesmenes is proposed.
      PubDate: 2014-06-17T03:17:03.505314-05:
      DOI: 10.1002/cbdv.201300247
  • Tenualexin, Other Phytoalexins and Indole Glucosinolates from Wild
           Cruciferous Species
    • Authors: M. Soledade C. Pedras; Estifanos E. Yaya
      Pages: 910 - 918
      Abstract: In general, the chemodiversity of phytoalexins, elicited metabolites involved in plant defense mechanisms against microbial pathogens, correlates with the biodiversity of their sources. In this work, the phytoalexins produced by four wild cruciferous species (Brassica tournefortii, Crambe abyssinica (crambe), Diplotaxis tenuifolia (sand rocket), and Diplotaxis tenuisiliqua (wall rocket)) were identified and quantified by HPLC with photodioarray and electrospray mass detectors. In addition, the production of indole glucosinolates, biosynthetic precursors of cruciferous phytoalexins, was evaluated. Tenualexin, (=2-(1,4-dimethoxy-1H-indol-3-yl)acetonitrile), the first cruciferous phytoalexin containing two MeO substituents in the indole ring, was isolated from D. tenuisiliqua, synthesized, and evaluated for antifungal activity. The phytoalexins cyclobrassinin and spirobrassinin were detected in B. tournefortii and C. abyssinica, whereas rutalexin and 4-methoxybrassinin were only found in B. tournefortii. D. tenuifolia, and D. tenuisiliqua produced 2-(1H-indol-3-yl)acetonitriles as phytoalexins. Because tenualexin appears to be one of the broad-range antifungals occurring in crucifers, it is suggested that D. tenuisiliqua may have disease resistance traits important to be incorporated in commercial breeding programs.
      PubDate: 2014-06-17T03:17:05.9344-05:00
      DOI: 10.1002/cbdv.201300260
  • Sesquiterpenoids from Chloranthus henryi and Their Anti-neuroinflammatory
    • Authors: Li-Jun Wang; Juan Xiong, Shu-Ting Liu, Xin-Hua Liu, Jin-Feng Hu
      Pages: 919 - 928
      Abstract: Five new and seven known mono-sesquiterpenoids (1–5 and 6–12, resp.) together with five known lindenane-type disesquiterpenoids, 13–17, were isolated from the whole plant of Chloranthus henryi. Based on spectroscopic methods, the new structures were established to be (5S,6R,8S,10R)-6-hydroxyeudesma-4(15),7(11)-diene-12,8-olide (1), 6α-hydroxyeudesma-4(15),7(11),8(9)-triene-12,8-olide (2), 8,12-epoxy-1β-hydroxyeudesma-4(15),7,11-trien-6-one (3), 12-oxochloraniolide A (4), and (4α)-8-hydroxy-12-norcardina-6,8,10-trien-11-one (5), respectively. Among the isolates, compound 2, zederone epoxide (8), spicachlorantin G (13), chloramultilide A (14), shizukaol B (15), and spicachlorantin B (17) showed significant anti-neuroinflammatory effects by inhibiting nitric-oxide (NO) production in lipopolysaccharide (LPS)-stimulated murine BV-2 microglial cells with relatively low cytotoxicity.
      PubDate: 2014-06-17T03:17:03.907993-05:
      DOI: 10.1002/cbdv.201300283
  • Two New Butenolides Produced by an Actinomycete Streptomyces sp.
    • Authors: Tang Wang; Yi Jiang, Kai-Xia Ma, Yi-Qing Li, Rong Huang, Xiao-Song Xie, Shao-Hua Wu
      Pages: 929 - 933
      Abstract: Two new butenolides, (4S)-4,10-dihydroxydodec-2-en-1,4-olide (1) and (4S)-4,8,10-trihydroxy-10-methyldodec-2-en-1,4-olide (2), together with three known compounds, MKN-003B (3), MKN-003C (4), and cyclo(Ala-Leu) (5), were isolated from the culture broth of a bacterium of the genus Streptomyces derived from soil environment. The structures of these compounds were elucidated on the basis of spectroscopic analysis. The inhibitory activities of the butenolides against eight pathogenic fungi were evaluated. All of the butenolides showed moderate-or-weak antifungal activities in a broth microdilution assay.
      PubDate: 2014-06-17T03:17:05.685078-05:
      DOI: 10.1002/cbdv.201300321
  • Essential-Oil Composition of the Needles Collected from Natural
           Populations of Macedonian Pine (Pinus peuce Griseb.) from the
           Scardo-Pindic Mountain System
    • Authors: Biljana Nikolić; Mihailo Ristić, Srdjan Bojović, Vlado Matevski, Zoran Krivošej, Petar D. Marin
      Pages: 934 - 948
      Abstract: The needle-terpene profiles of two natural Pinus peuce populations from the Scardo-Pindic mountain system (Mt. Ošljak and Mt. Pelister) were analyzed. Among the 90 detected compounds, 87 were identified. The dominant constituents were α-pinene (45.5%), germacrene D (11.1%), β-pinene (10.8%), and camphene (10.3%). The following eight additional components were found to be present in medium-to-high amounts (0.5–10%): bornyl acetate (5.0%), β-phellandrene (3.4%), β-caryophyllene (2.9%), β-myrcene (0.9%), germacrene D-4-ol (0.9%), tricyclene (0.7%), (E)-hex-2-enal (0.7%), and bicyclogermacrene (0.6%). Although the general needle-terpene profiles of the populations from Mt. Ošljak and Mt. Pelister were found to be similar to those of the populations from Zeletin, Sjekirica, and Mokra Gora (Dinaric Alps), principle component analysis (PCA) of eight terpenes (α-pinene, β-myrcene, α-terpinolene, bornyl acetate, α-terpinyl acetate, β-caryophyllene, trans-β-farnesene, and germacrene D) in 139 tree samples suggested a divergence between the two population groups, i.e., the samples from the Scardo-Pindic mountain system and those from the Dinaric Alps. Genetic analysis of the β-pinene content demonstrated a partial divergence between the two geographical groups. The profiles of both population groups differed from those published for populations from the Balkan-Rhodope mountains system (literature results), which were characterized by high contents of bornyl acetate and citronellol (Greek populations) or δ-car-3-ene (Bulgarian populations).
      PubDate: 2014-06-17T03:17:05.389629-05:
      DOI: 10.1002/cbdv.201300343
  • Inhibitory Effects of Constituents of an Endophytic Fungus Hypoxylon
           investiens on Nitric Oxide and Interleukin-6 Production in RAW264.7
    • Authors: Chun-Wei Chang; Hsun-Shuo Chang, Ming-Jen Cheng, Ta-Wei Liu, Sung-Yuan Hsieh, Gwo-Fang Yuan, Ih-Sheng Chen
      Pages: 949 - 961
      Abstract: Three new compounds, hypoxyloamide (1), 8-methoxynaphthalene-1,7-diol (2), and hypoxylonol (3), together with seven compounds isolated from nature for the first time, investiamide (4), hypoxypropanamide (5), hypoxylonol A (6), investienol (7), 2-heptylfuran (8), (3S)-5-methyl-8-O-methylmellein (9), (4R)-O-methylsclerone (10), along with 19 known compounds, 11–29, were isolated from the culture broth of Hypoxylon investiens BCRC 10F0115, a fungal endophyte residing in the stems of an endemic Formosan plant Litsea akoensis var. chitouchiaoensis. The structures of the new compounds were established by spectroscopic methods, including UV, IR, HR-ESI-MS, and extensive 1D- and 2D-NMR techniques. Of these isolates, 2, 8-methoxynaphthalen-1-ol (15), and 1,8-dimethoxynaphthalene (16) showed nitric oxide (NO) inhibitory activity with IC50 values of 11.8±0.9, 17.8±1.1, and 13.3±0.5 μM, respectively, stronger than the positive control quercetin (IC50 36.8±1.3 μM). Compounds 2, 15, and 16 also showed interleukin-6 (IL-6) inhibitory activity with IC50 values of 9.2±1.7, 18.0±0.6, and 2.0±0.1 μM, stronger than the positive control quercetin (IC50 31.3±1.6 μM). To the best of our knowledge, this is the first report on guaiane sesquiterpene metabolites, 3, 6, and 7, from the genus Hypoxylon.
      PubDate: 2014-06-17T03:17:06.123897-05:
      DOI: 10.1002/cbdv.201300364
  • Anti-Adipogenic Activity of the Naturally Occurring Phenanthroindolizidine
           Alkaloid Antofine via Direct Suppression of PPARγ Expression
    • Authors: Eun Jung Jang; Hyo Kyeong Kim, Hana Jeong, Ye Seul Lee, Mi Gyeong Jeong, Su Jung Bae, Sanghee Kim, Sang Kook Lee, Eun Sook Hwang
      Pages: 962 - 969
      Abstract: Antofine (ANTF) is a phenanthroindolizidine alkaloid isolated from the root of Cynanchum paniculatum Kitagawa (Asclepiadaceae), which is used as an herbal remedy for pain and inflammation. ANTF also possesses antiviral and antitumorigenic activities. In this study, we investigated the role of ANTF in adipogenesis. Chronic ABTF administration suppressed adipocyte differentiation and marker expression in a dose-dependent manner. Furthermore, acute administration of ANTF at early stages of differentiation process inhibited lipid droplet formation and adipogenic gene expression. ANTF Treatment decreased expression of PPARγ protein, a master transcription factor in the regulation of adipocyte differentiation, leading to a suppression of aP2 promoter activity. These results suggest that ANTF exerts potent anti-adipogenic effects via direct suppression of PPARγ protein expression, with consequent downregulation of adipogenic gene expression.
      PubDate: 2014-06-17T03:17:04.134726-05:
      DOI: 10.1002/cbdv.201300365
  • Cytotoxic Mannopyranosides of Indole Alkaloids from Zanthoxylum nitidum
    • Authors: Jiang Hu; Xiaodong Shi, Xia Mao, Jiangang Chen, Hui Li
      Pages: 970 - 974
      Abstract: Three new mannopyranosides of indole alkaloids, methyl 7-(β-D-mannopyranosyloxy)-1H-indole-2-carboxylate (1), methyl 7-[(3-O-acetyl-β-D-mannopyranosyl)oxy]-1H-indole-2-carboxylate (2), and 2-methyl-1H-indol-7-yl β-D-mannopyranoside (3), were isolated from an EtOH extract of the roots of Zanthoxylum nitidum. Their structures were identified as new compounds on the basis of the spectroscopic analyses. Bioactivity evaluation revealed that these alkaloids possess significant cytotoxicities against all the tested tumor cell lines with IC50 values of less than 30 μM.
      PubDate: 2014-06-17T03:17:05.205865-05:
      DOI: 10.1002/cbdv.201300381
  • Cytotoxic Compounds from the Leaves of Garcinia polyantha
    • Authors: Alain Meli Lannang; Simplice J. N. Tatsimo, Hugues Fouotsa, Jean Paul Dzoyem, Ajit Kumar Saxena, Norbert Sewald
      Pages: 975 - 981
      Abstract: A new compound, named banganxanthone C (=12-(1,1-dimethylprop-2-en-1-yl)-5,10-dihydroxy-9-methoxy-2-methyl-2-(4-methylpent-3-en-1-yl)-2H,6H-pyrano[3,2-b]xanthen-6-one; 4), together with five known compounds, were isolated from the leaves of Garcinia polyantha. The structures of the compounds were elucidated on the basis of 1D- and 2D-NMR spectroscopy. Among the known compounds, two were xanthones, one was a pentacyclic triterpene, one sterol, and one benzophenone derivative. Isoxanthochymol (2) and 4-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-1,5,8-trihydroxy-3-methoxy-9H-xanthen-9-one (3) exhibited significant antiproliferative activity against the leukemia cell line TPH-1 with IC50 inhibition values of 1.5 and 2.8 μg/ml, respectively. The cytotoxic activity was found to be related to apoptosis induction.
      PubDate: 2014-06-17T03:17:03.680216-05:
      DOI: 10.1002/cbdv.201300401
  • New Triterpenoids from the Fruiting Bodies of Ganoderma lucidum and Their
    • Authors: Dong-Ze Liu; Yi-Qun Zhu, Xiao-Fei Li, Wei-Gang Shan, Peng-Fei Gao
      Pages: 982 - 986
      Abstract: Phytochemical investigation of the AcOEt extract of G. Lucidum has led to the isolation of two new triterpenoids, 1 and 2, together with five known ones, 3–7. The structures of the new compounds were identified as 12β-acetoxy-3β,7β-dihydroxy-11,15,23-trioxolanost-8-en-26-oic acid butyl ester (1) and 12β-acetoxy-3,7,11,15,23-pentaoxolanost-8-en-26-oic acid butyl ester (2) on the basis of detailed spectroscopic analysis (mass spectrometry, and 1D- and 2D-NMR experiments). The antimicrobial activities of 1 and 2 were also evaluated.
      PubDate: 2014-06-17T03:17:04.33413-05:0
      DOI: 10.1002/cbdv.201400004
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