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CHEMISTRY (532 journals)                  1 2 3 4 5 6 | Last

2D Materials     Hybrid Journal   (Followers: 1)
Accreditation and Quality Assurance: Journal for Quality, Comparability and Reliability in Chemical Measurement     Hybrid Journal   (Followers: 31)
ACS Catalysis     Full-text available via subscription   (Followers: 23)
ACS Chemical Neuroscience     Full-text available via subscription   (Followers: 13)
ACS Combinatorial Science     Full-text available via subscription   (Followers: 8)
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ACS Medicinal Chemistry Letters     Full-text available via subscription   (Followers: 25)
ACS Nano     Full-text available via subscription   (Followers: 249)
ACS Photonics     Full-text available via subscription   (Followers: 2)
ACS Synthetic Biology     Full-text available via subscription   (Followers: 8)
Acta Chemica Iasi     Open Access  
Acta Chimica Slovaca     Open Access   (Followers: 5)
Acta Chromatographica     Full-text available via subscription   (Followers: 10)
Acta Facultatis Medicae Naissensis     Open Access   (Followers: 1)
Acta Metallurgica Sinica (English Letters)     Hybrid Journal   (Followers: 4)
adhäsion KLEBEN & DICHTEN     Hybrid Journal   (Followers: 2)
Adhesion Adhesives & Sealants     Hybrid Journal   (Followers: 4)
Adsorption Science & Technology     Full-text available via subscription   (Followers: 8)
Advanced Functional Materials     Hybrid Journal   (Followers: 32)
Advances in Chemical Engineering and Science     Open Access   (Followers: 21)
Advances in Chemical Science     Open Access   (Followers: 8)
Advances in Colloid and Interface Science     Full-text available via subscription   (Followers: 13)
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Advances in Fluorine Science     Full-text available via subscription   (Followers: 7)
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Advances in Heterocyclic Chemistry     Full-text available via subscription   (Followers: 8)
Advances in Materials Physics and Chemistry     Open Access   (Followers: 12)
Advances in Nanoparticles     Open Access   (Followers: 11)
Advances in Organometallic Chemistry     Full-text available via subscription   (Followers: 8)
Advances in Polymer Science     Hybrid Journal   (Followers: 38)
Advances in Protein Chemistry     Full-text available via subscription   (Followers: 6)
Advances in Protein Chemistry and Structural Biology     Full-text available via subscription   (Followers: 10)
Advances in Quantum Chemistry     Full-text available via subscription   (Followers: 4)
African Journal of Chemical Education     Open Access   (Followers: 1)
African Journal of Pure and Applied Chemistry     Open Access   (Followers: 2)
Afrique Science : Revue Internationale des Sciences et Technologie     Open Access  
Agrokémia és Talajtan     Full-text available via subscription   (Followers: 2)
Alchemy     Open Access   (Followers: 2)
Alkaloids: Chemical and Biological Perspectives     Full-text available via subscription   (Followers: 4)
AMB Express     Open Access   (Followers: 1)
American Journal of Applied Sciences     Open Access   (Followers: 28)
American Journal of Biochemistry and Biotechnology     Open Access   (Followers: 148)
American Journal of Biochemistry and Molecular Biology     Open Access   (Followers: 11)
American Journal of Chemistry     Open Access   (Followers: 17)
American Journal of Plant Physiology     Open Access   (Followers: 9)
American Mineralogist     Full-text available via subscription   (Followers: 2)
Analyst     Full-text available via subscription   (Followers: 35)
Angewandte Chemie     Hybrid Journal   (Followers: 15)
Angewandte Chemie International Edition     Hybrid Journal   (Followers: 201)
Annales UMCS, Chemia     Open Access   (Followers: 2)
Annual Reports in Computational Chemistry     Full-text available via subscription   (Followers: 1)
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Annual Review of Chemical and Biomolecular Engineering     Full-text available via subscription   (Followers: 10)
Annual Review of Food Science and Technology     Full-text available via subscription   (Followers: 12)
Anti-Infective Agents     Hybrid Journal   (Followers: 1)
Applied Organometallic Chemistry     Hybrid Journal   (Followers: 4)
Applied Spectroscopy     Full-text available via subscription   (Followers: 12)
Applied Surface Science     Hybrid Journal   (Followers: 14)
Arabian Journal of Chemistry     Full-text available via subscription   (Followers: 6)
ARKIVOC     Open Access   (Followers: 1)
Asian Journal of Biochemistry     Open Access   (Followers: 1)
Australian Journal of Chemistry     Hybrid Journal   (Followers: 4)
Autophagy     Full-text available via subscription  
Avances en Quimica     Open Access   (Followers: 1)
Biochemical Pharmacology     Hybrid Journal   (Followers: 6)
Biochemistry     Full-text available via subscription   (Followers: 186)
Biochemistry Insights     Open Access   (Followers: 4)
Biochemistry Research International     Open Access   (Followers: 4)
BioChip Journal     Hybrid Journal   (Followers: 1)
Bioinorganic Chemistry and Applications     Open Access   (Followers: 4)
Biointerface Research in Applied Chemistry     Open Access   (Followers: 1)
Biointerphases     Open Access  
Biomacromolecules     Full-text available via subscription   (Followers: 17)
Biomass Conversion and Biorefinery     Partially Free   (Followers: 5)
Biomedical Chromatography     Hybrid Journal   (Followers: 7)
Biomolecular NMR Assignments     Hybrid Journal   (Followers: 2)
BioNanoScience     Partially Free   (Followers: 4)
Bioorganic & Medicinal Chemistry     Hybrid Journal   (Followers: 30)
Bioorganic & Medicinal Chemistry Letters     Hybrid Journal   (Followers: 24)
Bioorganic Chemistry     Hybrid Journal   (Followers: 5)
Biopolymers     Hybrid Journal   (Followers: 13)
Biosensors     Open Access   (Followers: 3)
Biotechnic and Histochemistry     Hybrid Journal   (Followers: 1)
Boletin de la Sociedad Chilena de Quimica     Open Access  
Bulletin of the Chemical Society of Ethiopia     Open Access   (Followers: 1)
Bulletin of the Chemical Society of Japan     Full-text available via subscription   (Followers: 12)
Canadian Association of Radiologists Journal     Full-text available via subscription   (Followers: 3)
Canadian Journal of Chemistry     Full-text available via subscription   (Followers: 6)
Canadian Mineralogist     Full-text available via subscription   (Followers: 1)
Carbohydrate Research     Hybrid Journal   (Followers: 10)
Carbon     Hybrid Journal   (Followers: 37)
Catalysis for Sustainable Energy     Open Access   (Followers: 2)
Catalysis Reviews: Science and Engineering     Hybrid Journal   (Followers: 4)
Catalysis Science and Technology     Free   (Followers: 4)
Catalysis Surveys from Asia     Hybrid Journal   (Followers: 4)
Catalysts     Open Access   (Followers: 6)
Cellulose     Hybrid Journal   (Followers: 4)
Central European Journal of Chemistry     Hybrid Journal   (Followers: 5)
Cereal Chemistry     Full-text available via subscription   (Followers: 3)

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Journal Cover Chemistry & Biodiversity
   Journal TOC RSS feeds Export to Zotero [7 followers]  Follow    
   Hybrid Journal Hybrid journal (It can contain Open Access articles)
     ISSN (Print) 1612-1872 - ISSN (Online) 1612-1880
     Published by John Wiley and Sons Homepage  [1604 journals]   [SJR: 0.541]   [H-I: 35]
  • Contents: C&B 8/2014
    • PubDate: 2014-08-22T04:29:53.083759-05:
      DOI: 10.1002/cbdv.201490008
  • Cytotoxic and Nitric Oxide Production‐Inhibitory Activities of
    • Authors: Xin Pan; Masahiro Matsumoto, Yuki Nishimoto, Eri Ogihara, Jie Zhang, Motohiko Ukiya, Harukuni Tokuda, Kazuo Koike, Momoko Akihisa, Toshihiro Akihisa
      First page: 1121
      Abstract: Nine limonoids, 1–9, one apocarotenoid, 11, one alkaloid, 12, and one steroid, 13, from the leaf extract; and one triterpenoid, 10, five steroids, 14–18, and two flavonoids, 19 and 20, from the bark extract of Melia azedarach L. (Chinaberry tree; Meliaceae) were isolated. Among these compounds, three compounds, 4–6, were new, and their structures were established as 3‐deacetyl‐28‐oxosalannolactone, 3‐deacetyl‐28‐oxosalanninolide, and 3‐deacetyl‐17‐defurano‐17,28‐dioxosalannin, respectively, on the basis of extensive spectroscopic analyses and comparison with literature data. All of the isolated compounds were evaluated for their cytotoxic activities against leukemia (HL60), lung (A549), stomach (AZ521), and breast (SK‐BR‐3) cancer cell lines. 3‐Deacetyl‐4′‐demethyl‐28‐oxosalannin (3) against HL60 and AZ521 cells, and methyl kulonate (10) against HL60 cells exhibited potent cytotoxicities with IC50 values in the range of 2.8–5.8 μM. In addition, upon evaluation of compounds 1–13 against production of nitric oxide (NO) in mouse macrophage RAW 264.7 cells induced by lipopolysaccharide (LPS), seven, i.e., trichilinin B (1), 4, ohchinin (7), 23‐hydroxyohchininolide (8), 21‐hydroxyisoohchininolide (9), 10, and methyl indole 3‐carboxylate (12), inhibited production of NO with IC50 values in the range of 4.6–87.3 μM with no, or almost no, toxicity to the cells (IC50 93.2–100 μM). Western blot analysis revealed that compound 7 reduced the expression levels of the inducible NO synthase (iNOS) and COX‐2 proteins in a concentration‐dependent manner. Furthermore, compounds 5, 6, 13, and 18–20 exhibited potent inhibitory effects (IC50 299–381 molar ratio/32 pmol TPA) against EpsteinBarr virus early antigen (EBV‐EA) activation induced by 12‐O‐tetradecanoylphorbol‐13‐acetate (TPA) in Raji cell line.
      PubDate: 2014-08-22T04:29:52.516201-05:
      DOI: 10.1002/cbdv.201400190
  • Adsorbents for Apheresis Prepared from Polysaccharides of Algae that
           Threaten Ecosystem Services
    • Authors: Kenichi Kanno; Tetsuya Tanigawa, Yoshihiro Fujita, Naoto Ohnaka, Yuichiro Kubo, Kaito Yoshida, Kota Kojima, Koshiro Nakata, Masafumi Shimohara
      First page: 1140
      Abstract: In this work, we investigated whether materials isolated from algae that threaten ecosystems can be used for human benefit. We converted acidic polysaccharides (ulvan) from the alga Ulva pertusa into soft hydrogel materials. In addition to ulvan, the hydrogels also contained alginate in a polyion complex with chitosan. Cross‐linking the hydrogel with glutaraldehyde reduced polysaccharide elution from the polyion complex gel. We also found that both ulvanchitosan and alginatechitosan gels were able to remove urea and heavy metals from aqueous solution. This is clinically significant, since during apheresis, toxic compounds such as urea have to be removed from the bloodstream of patients. Importantly, albumin was not removed by the hydrogels, implying that this vital protein can be returned to the bloodstream following dialysis.
      PubDate: 2014-08-22T04:29:56.130724-05:
      DOI: 10.1002/cbdv.201400108
  • Binding Pockets and Pathways for Dioxygen through the KijD3
           N‐Oxygenase in Complex with Flavin Mononucleotide Cofactor and a
           3‐Aminoglucose Substrate: Predictions from Molecular Dynamics
    • Authors: Francesco Pietra
      First page: 1151
      Abstract: In this work, two protein systems, Kij3DFMNAKMO2 and Kij3DFMNO2, made of KijD3 N‐oxygenase, flavin mononucleotide (FMN) cofactor, dTDP‐3‐amino‐2,3,6‐trideoxy‐4‐keto‐3‐methyl‐D‐glucose (AKM) substrate, and dioxygen (O2), have been assembled by adding a molecule of O2, and removing (or not) AKM, to crystal data for the Kij3DFMNAKM complex. Egress of AKM and O2 from these systems was then investigated by applying a tiny external random force, in turn, to their center of mass in the course of molecular dynamics in explicit H2O. It turned out that the wide AKM channel, even when emptied, does not constitute the main route for O2 egress. Other routes appear to be also viable, while various binding pockets (BPs) outside the active center are prone to trap O2. By reversing the reasoning, these can also be considered as routes for uptake of O2 by the protein, before or after AKM uptake, while BPs may serve as reservoirs of O2. This shows that the small molecule O2 is capable of permeating the protein by exploiting all nearby interstices that are created on thermal fluctuations of the protein, rather than having necessarily to look for farther, permanent channels.
      PubDate: 2014-08-22T04:29:51.471808-05:
      DOI: 10.1002/cbdv.201400081
  • Solution Synthesis, Conformational Analysis, and Antimicrobial Activity of
           Three Alamethicin F50/5 Analogs Bearing a Trifluoroacetyl Label
    • Authors: Marta De Zotti; Gema Ballano, Micha Jost, Evgeniy S. Salnikov, Burkhard Bechinger, Simona Oancea, Marco Crisma, Claudio Toniolo, Fernando Formaggio
      First page: 1163
      Abstract: We prepared, by solution‐phase methods, and fully characterized three analogs of the membrane‐active peptaibiotic alamethicin F50/5, bearing a single trifluoroacetyl (Tfa) label at the N‐terminus, at position 9 (central region) or at position 19 (C‐terminus), and with the three Gln at positions 7, 18, and 19 replaced by Glu(OMe) residues. To add the Tfa label at position 9 or 19, a γ‐trifluoroacetylated α,γ‐diaminobutyric acid (Dab) residue was incorporated as a replacement for the original Val9 or Glu(OMe)19 amino acid. We performed a detailed conformational analysis of the three analogs (using FT‐IR absorption, CD, 2D‐NMR, and X‐ray diffraction), which clearly showed that Tfa labeling does not introduce any dramatic backbone modification in the predominantly α‐helical structure of the parent peptaibiotic. The results of an initial solid‐state 19F‐NMR study on one of the analogs favor the conclusion that the Tfa group is a very promising reporter for the analysis of peptaibioticmembrane interactions. Finally, we found that the antimicrobial activities of the three newly synthesized analogs depend on the position of the Tfa label in the peptide sequence.
      PubDate: 2014-08-22T04:29:55.52279-05:0
      DOI: 10.1002/cbdv.201300394
  • Insecticidal Metabolites from the Rhizomes of Veratrum album against
           Adults of Colorado Potato Beetle, Leptinotarsa decemlineata
    • Authors: Tuba Aydin; Ahmet Cakir, Cavit Kazaz, Neslihan Bayrak, Yasin Bayir, Yavuz Taşkesenligil
      First page: 1192
      Abstract: The dried rhizomes of Veratrum album were individually extracted with CHCl3, acetone, and NH4OH/benzene to test the toxic effects against the Colorado potato beetle, Leptinotarsa decemlineata, which is an important agricultural pest. Fifteen compounds in various amounts were isolated from the extracts using column and thin‐layer chromatography. The chemical structures of 14 compounds were characterized as octacosan‐1‐ol (1), β‐sitosterol (2), stearic acid (3), diosgenin (4), resveratrol (5), wittifuran X (6), oxyresveratrol (7), β‐sitosterol 3‐O‐β‐D‐glucopyranoside (8), diosgenin 3‐O‐α‐L‐rhamnopyranosyl‐(1→2)‐β‐D‐glucopyronoside (9), oxyresveratrol 3‐O‐β‐D‐glucopyranoside (10), jervine (11), pseudojervine (13), 5,6‐dihydro‐1‐hydroxyjervine (14), and saccharose (15) using UV, IR, MS, 1H‐ and 13C‐NMR, and 2D‐NMR spectroscopic methods. However, the chemical structure of 12, an oligosaccharide, has not fully been elucidated. Compounds 4, 6, 9, and 10 were isolated from V. album rhizomes for the first time in the current study. The toxic effects of three extracts (acetone, CHCl3, and NH4OH/benzene) and six metabolites, 2, 2+4, 5, 7, 8, and 11, were evaluated against the Colorado potato beetle. The assay revealed that all three extracts, and compounds 7, 8, and 11 exhibited potent toxic effects against this pest. This is the first report on the evaluation of the toxic effects of the extracts and secondary metabolites of V. album rhizomes against L. decemlineata. Based on these results, it can be concluded that the extracts can be used as natural insecticides.
      PubDate: 2014-08-22T04:29:51.933322-05:
      DOI: 10.1002/cbdv.201300407
  • Essential‐Oil Diversity of Salvia tomentosa Mill. in Greece
    • Authors: Effie Hanlidou; Regina Karousou, Diamanto Lazari
      First page: 1205
      Abstract: Salvia tomentosa essential oils from Greece were studied for the first time here. The oils from five populations growing in Mediterranean pine forests on the island of Thassos (northern Aegean Sea) and from 14 populations situated in deciduous forests in Thrace (northeastern Greek mainland) were investigated. Their essential‐oil contents ranged from 1.1 to 3.3% (v/w, based on the dry weight of the plant material). The populations from Thassos had high contents of α‐pinene (18.0±2.9%), 1,8‐cineole (14.7±3.0%), cis‐thujone (14.0±6.9%), and borneol (12.8±2.2%) and smaller amounts of camphene, camphor, and β‐pinene, whereas the populations from Thrace showed high α‐pinene (16.7±4.0%), β‐pinene (22.8±4.5%), camphor (18.3±4.3%), and camphene (10.3±2.4%) contents, much lower 1,8‐cineole and borneol amounts, while cis‐thujone was completely lacking. The comparison of the present results with published data showed that oils having cis‐thujone as one of the main compounds were reported for the first time here. Multivariate statistical analyses indicate that the observed essential‐oil variation was related to geographical and environmental factors.
      PubDate: 2014-08-22T04:29:54.384378-05:
      DOI: 10.1002/cbdv.201300408
  • Chemical Composition and Phytotoxic Effects of Essential Oils Obtained
           from Ailanthus altissima (Mill.) Swingle Cultivated in Tunisia
    • Authors: Asma El Ayeb‐Zakhama; Saoussen Ben Salem, Lamia Sakka‐Rouis, Guido Flamini, Hichem Ben Jannet, Fethia Harzallah‐Skhiri
      First page: 1216
      Abstract: Ailanthus altissima Mill. Swingle (Simaroubaceae), also known as tree of heaven, is used in the Chinese traditional medicine as a bitter aromatic drug for the treatment of colds and gastric diseases. In Tunisia, Ailanthus altissima is an exotic tree, which was introduced many years ago and used particularly as a street ornamental tree. Here, the essential oils of different plant parts of this tree, viz., roots, stems, leaves, flowers, and samaras (ripe fruits), were obtained by hydrodistillation. In total, 69 compounds, representing 91.0–97.2% of the whole oil composition, were identified in these oils by GC‐FID and GC/MS analyses. The root essential oil was clearly distinguishable for its high content in aldehydes (hexadecanal (1); 22.6%), while those obtained from flowers and leaves were dominated by oxygenated sesquiterpenes (74.8 and 42.1%, resp.), with caryophyllene oxide (4) as the major component (42.5 and 22.7%, resp.). The samara oil was rich in the apocarotenoid derivative hexahydrofarnesyl acetone (6; 58.0%), and the oil obtained from stems was characterized by sesquiterpene hydrocarbons (54.1%), mainly β‐caryophyllene (18.9%). Principal component and hierarchical cluster analyses separated the five essential oils into four groups, each characterized by the major oil constituents. Contact tests showed that the germination of lettuce seeds was totally inhibited by all the essential oils except of the samara oil at a dose of 1 mg/ml. The flower oil also showed a significant phytotoxic effect against lettuce germination at 0.04 and 0.4 mg/ml (−55.0±3.5 and −85.0±0.7%, resp.). Moreover, the root and shoot elongation was even more affected by the oils than germination. The inhibitory effect of the shoot and root elongation varied from −9.8 to −100% and from −38.6 to −100%, respectively. Total inhibition of the elongation (−100%) at 1 mg/ml was detected for all the oils, with the exception of the samara oil (−74.7 and −75.1% for roots and shoots, resp.).
      PubDate: 2014-08-22T04:29:53.164661-05:
      DOI: 10.1002/cbdv.201300409
  • Essential Oil from Blackcurrant Buds as Chemotaxonomy Marker and
           Antimicrobial Agent
    • Authors: Boban S. Ðorđević; Dejan S. Pljevljakušić, Katarina P. Šavikin, Tatjana R. Stević, Dubravka J. Bigović
      First page: 1228
      Abstract: Dormant buds are recognized as valuable side product of the blackcurrant cultivation. Four blackcurrant varieties cultivated in Serbia, i.e., Ben Sarek, Ometa, Ben Lomond, and Ben Nevis, were evaluated for the content, chemical composition, and antimicrobial activity of their bud essential oils. The oil yields of buds harvested during two different growth periods ranged from 1.2–2.0%, and the variety Ometa had the highest yield among the tested varieties. GC‐FID and GC/MS analysis of the oils allowed the identification of eight main components, i.e., α‐pinene (1.6–5.4%), sabinene (1.9–38.4%), δ‐car‐3‐ene (13.0–50.7%), β‐phellandrene (2.9–18.0%), terpinolene (6.6–11.9%), terpinen‐4‐ol (0.9–6.6%), β‐caryophyllene (3.8–10.4%), and α‐humulene (0.2–4.1%). In addition, the similarity degree of the essential‐oil compositions of buds harvested from the upper and lower parts of the shrubs was investigated by hierarchical clustering. All essential oils originating from the same genotype were grouped in the same cluster, indicating the reliability of essential oils as chemotaxonomic markers. For more detailed chemotaxonomic investigations, the three compounds with the greatest variance were chosen, i.e., sabinene, δ‐car‐3‐ene, and β‐phellandrene, which proved to be efficient for the variety distinction. Factor analysis showed that the essential‐oil composition as chemotaxonomic marker in blackcurrants was more reliable for variety Ben Sarek than for variety Ben Nevis. Moreover, it was demonstrated that the essential oils had very strong inhibitory activity against all tested microorganisms. Fungi were more sensitive than bacteria; indeed their growth was completely inhibited at much lower concentrations. In comparison to commercial antibiotics, significantly lower concentrations of the oils were necessary for the complete inhibition of fungal growth.
      PubDate: 2014-08-22T04:29:54.700673-05:
      DOI: 10.1002/cbdv.201400039
  • Microjaponin, A New Dihydroagarofuranoid Sesquiterpene from the Stem of
           Microtropis japonica with Antituberculosis Activity
    • Authors: Jih‐Jung Chen; Wen‐Lung Kuo, Ih‐Sheng Chen, Chien‐Fang Peng, Ping‐Jyun Sung, Ming‐Jen Cheng, Yun‐Ping Lim
      First page: 1241
      Abstract: A new dihydroagarofuran‐based sesquiterpene, microjaponin (1), was isolated from the stem of Microtropis japonica. Its structure was determined by in‐depth spectroscopic and mass‐spectrometric analyses. Microjaponin (1) exhibited potent in vitro antituberculosis activity, with an MIC value of 12.5 μg/ml against Mycobacterium tuberculosis H37Rv.
      PubDate: 2014-08-22T04:29:55.289276-05:
      DOI: 10.1002/cbdv.201400066
  • Phytotoxic Potential of Onopordum acanthium L. (Asteraceae)
    • Authors: Yusuke Watanabe; Paula Novaes, Rosa M. Varela, José M. G. Molinillo, Hisashi Kato‐Noguchi, Francisco A. Macías
      First page: 1247
      Abstract: Onopordum acanthium L. (Asteraceae) is a plant native to southern Europe and southwestern Asia, but it is invasive in disturbed areas and agricultural fields around the world, causing many agronomic problems by interfering with crops or preventing animals from grazing on pastures. Allelopathy could be one of the reasons that this plant has spread over different continents. The aim of the present study was to bioprospect O. acanthium leaf extracts through the isolation and purification of allelopathic secondary metabolites with phytotoxicity to explain their invasive behavior. Phytotoxic activity was tested using etiolated wheat coleoptiles. The most active extract was selected to perform a bioassay‐guided isolation of two flavonoids, pectolarigenin (1) and scutellarein 4′‐methyl ether (2), and two sesquiterpene lactones, elemanolide 11(13)‐dehydromelitensin β‐hydroxyisobutyrate (3) and acanthiolide (4). All compounds were isolated for the first time from O. acanthium, and acanthiolide (4) is described for the first time. Compound 3 strongly inhibited the growth of wheat coleoptiles and 1 showed an intermediate effect. The results indicate that these compounds could contribute to the invasion of O. acanthium in ecological systems and agricultural fields.
      PubDate: 2014-08-22T04:29:50.823994-05:
      DOI: 10.1002/cbdv.201400070
  • Structure–Activity Relationships of Strychnine Analogs at Glycine
    • Authors: Amal M. Y. Mohsen; Eberhard Heller, Ulrike Holzgrabe, Anders A. Jensen, Darius P. Zlotos
      First page: 1256
      Abstract: Nine strychnine derivatives including neostrychnine, strychnidine, isostrychnine, 21,22‐dihydro‐21‐hydroxy‐22‐oxo‐strychnine, and several hydrogenated analogs were synthesized, and their antagonistic activities at human α1 and α1β glycine receptors were evaluated. Isostrychnine has shown the best pharmacological profile exhibiting an IC50 value of 1.6 μM at α1 glycine receptors and 3.7‐fold preference towards the α1 subtype. SAR Analysis indicates that the lactam moiety and the C(21)C(22) bond in strychnine are essential structural features for its high antagonistic potency at glycine receptors
      PubDate: 2014-08-22T04:29:53.543055-05:
      DOI: 10.1002/cbdv.201400110
  • Total Mercury in Sediments, Macrophytes, and Fish from a Shallow Steppe
           Lake in Eastern Austria
    • Authors: Franz Jirsa; Daniel Pirker, Regina Krachler, Bernhard K. Keppler
      First page: 1263
      Abstract: During summer 2011, samples of sediment, macrophytes, and fish tissues from the shallow, slightly alkaline Lake Neusiedl, Austria, were evaluated for their total Hg content. This is the first report of Hg levels from this lake. Sediments displayed Hg contents between 0.025 and 0.113 μg g−1 dw (dry weight), significantly correlating with the proportion of organic components pointing to a small anthropogenic impact on the lake's Hg content. Hg Levels in plants and fish were unexpectedly high: both investigated submerged plant species, Potamogeton pectinatus and Myriophyllum spicatum, showed mean values of 0.245±0.152 and 0.298±0.115 μg g−1 dw, respectively. Biomagnification was evident when comparing muscle samples of the planktivorous fish species rudd Scardinus erythrophthalmus (n=10, mean=0.084 μg g−1 ww (wet weight)) with the piscivorous perch Perca fluviatilis (n=21, mean=0.184 μg g−1 ww) or pike‐perch Sander lucioperca (n=9, mean=0.205 μg g−1 ww). Significantly lower values were found in the muscle of the piscivorous pike Esox lucius (n=25, mean=0.135 μg g−1 ww), pointing to a specific Hg metabolism of this fish, presumably under the particular physicochemical properties of the lake. Hg Concentrations in fish could pose a risk to piscivorous birds in this protected wetland system.
      PubDate: 2014-08-22T04:29:53.936908-05:
      DOI: 10.1002/cbdv.201400172
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