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CHEMISTRY (531 journals)                  1 2 3 4 5 6 | Last

2D Materials     Hybrid Journal  
Accreditation and Quality Assurance: Journal for Quality, Comparability and Reliability in Chemical Measurement     Hybrid Journal   (Followers: 31)
ACS Catalysis     Full-text available via subscription   (Followers: 23)
ACS Chemical Neuroscience     Full-text available via subscription   (Followers: 13)
ACS Combinatorial Science     Full-text available via subscription   (Followers: 7)
ACS Macro Letters     Full-text available via subscription   (Followers: 17)
ACS Medicinal Chemistry Letters     Full-text available via subscription   (Followers: 24)
ACS Nano     Full-text available via subscription   (Followers: 235)
ACS Photonics     Full-text available via subscription   (Followers: 2)
ACS Synthetic Biology     Full-text available via subscription   (Followers: 8)
Acta Chemica Iasi     Open Access  
Acta Chimica Slovaca     Open Access   (Followers: 5)
Acta Chromatographica     Full-text available via subscription   (Followers: 9)
Acta Facultatis Medicae Naissensis     Open Access   (Followers: 1)
Acta Metallurgica Sinica (English Letters)     Hybrid Journal   (Followers: 2)
adhäsion KLEBEN & DICHTEN     Hybrid Journal   (Followers: 2)
Adhesion Adhesives & Sealants     Hybrid Journal   (Followers: 4)
Adsorption Science & Technology     Full-text available via subscription   (Followers: 8)
Advanced Functional Materials     Hybrid Journal   (Followers: 32)
Advances in Chemical Engineering and Science     Open Access   (Followers: 21)
Advances in Chemical Science     Open Access   (Followers: 8)
Advances in Colloid and Interface Science     Full-text available via subscription   (Followers: 13)
Advances in Drug Research     Full-text available via subscription   (Followers: 17)
Advances in Fluorine Science     Full-text available via subscription   (Followers: 7)
Advances in Fuel Cells     Full-text available via subscription   (Followers: 12)
Advances in Heterocyclic Chemistry     Full-text available via subscription   (Followers: 8)
Advances in Materials Physics and Chemistry     Open Access   (Followers: 12)
Advances in Nanoparticles     Open Access   (Followers: 11)
Advances in Organometallic Chemistry     Full-text available via subscription   (Followers: 8)
Advances in Polymer Science     Hybrid Journal   (Followers: 38)
Advances in Protein Chemistry     Full-text available via subscription   (Followers: 6)
Advances in Protein Chemistry and Structural Biology     Full-text available via subscription   (Followers: 10)
Advances in Quantum Chemistry     Full-text available via subscription   (Followers: 4)
African Journal of Chemical Education     Open Access   (Followers: 1)
African Journal of Pure and Applied Chemistry     Open Access   (Followers: 2)
Afrique Science : Revue Internationale des Sciences et Technologie     Open Access  
Agrokémia és Talajtan     Full-text available via subscription   (Followers: 2)
Alchemy     Open Access   (Followers: 2)
Alkaloids: Chemical and Biological Perspectives     Full-text available via subscription   (Followers: 4)
AMB Express     Open Access   (Followers: 1)
American Journal of Applied Sciences     Open Access   (Followers: 27)
American Journal of Biochemistry and Biotechnology     Open Access   (Followers: 141)
American Journal of Biochemistry and Molecular Biology     Open Access   (Followers: 11)
American Journal of Chemistry     Open Access   (Followers: 17)
American Journal of Plant Physiology     Open Access   (Followers: 9)
American Mineralogist     Full-text available via subscription   (Followers: 2)
Analyst     Full-text available via subscription   (Followers: 34)
Angewandte Chemie     Hybrid Journal   (Followers: 14)
Angewandte Chemie International Edition     Hybrid Journal   (Followers: 188)
Annales UMCS, Chemia     Open Access   (Followers: 2)
Annual Reports in Computational Chemistry     Full-text available via subscription   (Followers: 1)
Annual Reports Section A (Inorganic Chemistry)     Full-text available via subscription   (Followers: 2)
Annual Reports Section B (Organic Chemistry)     Full-text available via subscription   (Followers: 4)
Annual Review of Chemical and Biomolecular Engineering     Full-text available via subscription   (Followers: 10)
Annual Review of Food Science and Technology     Full-text available via subscription   (Followers: 12)
Anti-Infective Agents     Hybrid Journal   (Followers: 1)
Applied Organometallic Chemistry     Hybrid Journal   (Followers: 4)
Applied Spectroscopy     Full-text available via subscription   (Followers: 12)
Applied Surface Science     Hybrid Journal   (Followers: 14)
Arabian Journal of Chemistry     Full-text available via subscription   (Followers: 6)
ARKIVOC     Open Access   (Followers: 1)
Asian Journal of Biochemistry     Open Access   (Followers: 1)
Australian Journal of Chemistry     Hybrid Journal   (Followers: 4)
Autophagy     Full-text available via subscription  
Avances en Quimica     Open Access   (Followers: 1)
Biochemical Pharmacology     Hybrid Journal   (Followers: 6)
Biochemistry     Full-text available via subscription   (Followers: 173)
Biochemistry Insights     Open Access   (Followers: 4)
Biochemistry Research International     Open Access   (Followers: 4)
BioChip Journal     Hybrid Journal   (Followers: 1)
Bioinorganic Chemistry and Applications     Open Access   (Followers: 4)
Biointerface Research in Applied Chemistry     Open Access   (Followers: 1)
Biointerphases     Open Access  
Biomacromolecules     Full-text available via subscription   (Followers: 17)
Biomass Conversion and Biorefinery     Partially Free   (Followers: 5)
Biomedical Chromatography     Hybrid Journal   (Followers: 7)
Biomolecular NMR Assignments     Hybrid Journal   (Followers: 2)
BioNanoScience     Partially Free   (Followers: 4)
Bioorganic & Medicinal Chemistry     Hybrid Journal   (Followers: 30)
Bioorganic & Medicinal Chemistry Letters     Hybrid Journal   (Followers: 24)
Bioorganic Chemistry     Hybrid Journal   (Followers: 5)
Biopolymers     Hybrid Journal   (Followers: 12)
Biosensors     Open Access   (Followers: 3)
Biotechnic and Histochemistry     Hybrid Journal   (Followers: 1)
Boletin de la Sociedad Chilena de Quimica     Open Access  
Bulletin of the Chemical Society of Ethiopia     Open Access   (Followers: 1)
Bulletin of the Chemical Society of Japan     Full-text available via subscription   (Followers: 12)
Canadian Association of Radiologists Journal     Full-text available via subscription   (Followers: 3)
Canadian Journal of Chemistry     Full-text available via subscription   (Followers: 6)
Canadian Mineralogist     Full-text available via subscription   (Followers: 1)
Carbohydrate Research     Hybrid Journal   (Followers: 10)
Carbon     Hybrid Journal   (Followers: 34)
Catalysis for Sustainable Energy     Open Access   (Followers: 1)
Catalysis Reviews: Science and Engineering     Hybrid Journal   (Followers: 4)
Catalysis Science and Technology     Free   (Followers: 4)
Catalysis Surveys from Asia     Hybrid Journal   (Followers: 4)
Catalysts     Open Access   (Followers: 6)
Cellulose     Hybrid Journal   (Followers: 4)
Central European Journal of Chemistry     Hybrid Journal   (Followers: 5)
Cereal Chemistry     Full-text available via subscription   (Followers: 3)

        1 2 3 4 5 6 | Last

Journal Cover Chemistry & Biodiversity
   [7 followers]  Follow    
   Hybrid Journal Hybrid journal (It can contain Open Access articles)
     ISSN (Print) 1612-1872 - ISSN (Online) 1612-1880
     Published by John Wiley and Sons Homepage  [1603 journals]   [SJR: 0.541]   [H-I: 35]
  • Contents: C&B 7/2014
    • PubDate: 2014-07-15T05:56:54.362187-05:
      DOI: 10.1002/cbdv.201490007
  • Three New and Other Limonoids from the Hexane Extract of Melia azedarach
           Fruits and Their Cytotoxic Activities
    • Authors: Xin Pan; Masahiro Matsumoto, Yasuhiro Nakamura, Takashi Kikuchi, Jie Zhang, Motohiko Ukiya, Takashi Suzuki, Kazuo Koike, Rima Akihisa, Toshihiro Akihisa
      First page: 987
      Abstract: A defatted fraction obtained from the hexane extract of the fruits of Melia azedarach L. (chinaberry tree; Meliaceae) exhibited cytotoxic activities against leukemia (HL60), lung (A549), stomach (AZ521), and breast (SK‐BR‐3) cancer cell lines with IC50 values in the range of 2.9–21.9 μg/ml. Three new limonoids, 3‐deacetyl‐4′‐demethylsalannin (5), 3‐deacetyl‐28‐oxosalannin (14), and 1‐detigloylohchinolal (17), along with 16 known limonoids, 1–4, 6–13, 15, 16, 18, and 19, and one known triterpenoid, 20, were isolated from the fraction. The structures of new compounds were elucidated on the basis of extensive spectroscopic analyses and comparison with literature. These compounds were evaluated for their cytotoxic activities against the four cancer cell lines mentioned above. 3‐Deacetyl‐4′‐demethyl‐28‐oxosalannin (16), which exhibited potent cytotoxicity against AZ521 (IC50 3.2 μM) cells, induced typical apoptotic cell death in AZ521 cells upon evaluation of the apoptosis‐inducing activity by flow cytometry. This work provided, furthermore, valuable information on the structural features of limonoids of the fruits and/or seeds of Melia azedarach and related Meliaceae plants, M. toosendan and Azadirachta indica.
      PubDate: 2014-07-15T05:56:53.249467-05:
      DOI: 10.1002/cbdv.201400052
  • Toxicity of Thiophenes from Echinops transiliensis (Asteraceae) against
           Aedes aegypti (Diptera: Culicidae) Larvae
    • Authors: Hiroshi Nakano; Abbas Ali, Junaid Ur Rehman, Leonid K. Mamonov, Charles L. Cantrell, Ikhlas A. Khan
      First page: 1001
      Abstract: Structureactivity relationships of nine thiophenes, 2,2′: 5′,2″‐terthiophene (1), 2‐chloro‐4‐[5‐(penta‐1,3‐diyn‐1‐yl)thiophen‐2‐yl]but‐3‐yn‐1‐yl acetate (2), 4‐(2,2′‐bithiophen‐5‐yl)but‐3‐yne‐1,2‐diyl diacetate (3), 4‐[5‐(penta‐1,3‐diyn‐1‐yl)thiophen‐2‐yl]but‐3‐yne‐1,2‐diyl diacetate (4), 4‐(2,2′‐bithiophen‐5‐yl)‐2‐hydroxybut‐3‐yn‐1‐yl acetate (5), 2‐hydroxy‐4‐[5‐(penta‐1,3‐diyn‐1‐yl)thiophen‐2‐yl]but‐3‐yn‐1‐yl acetate (6), 1‐hydroxy‐4‐[5‐(penta‐1,3‐diyn‐1‐yl)thiophen‐2‐yl]but‐3‐yn‐2‐yl acetate (7), 4‐(2,2′‐bithiophen‐5‐yl)but‐3‐yne‐1,2‐diol (8), and 4‐[5‐(penta‐1,3‐diyn‐1‐yl)thiophen‐2‐yl]but‐3‐yne‐1,2‐diol (9), isolated from the roots of Echinops transiliensis, were studied as larvicides against Aedes aegypti. Structural differences among compounds 3, 5, and 8 consisted in differing AcO and OH groups attached to C(3″) and C(4″), and resulted in variations in efficacy. Terthiophene 1 showed the highest activity (LC50, 0.16 μg/ml) among compounds 1–9, followed by bithiophene compounds 3 (LC50, 4.22 μg/ml), 5 (LC50, 7.45 μg/ml), and 8 (LC50, 9.89 μg/ml), and monothiophene compounds 9 (LC50, 12.45 μg/ml), 2 (LC50, 14.71 μg/ml), 4 (LC50, 17.95 μg/ml), 6 (LC50, 18.55 μg/ml), and 7 (LC50, 19.97 μg/ml). These data indicated that A. aegypti larvicidal activities of thiophenes increase with increasing number of thiophene rings, and the most important active site in the structure of thiophenes could be the tetrahydro‐thiophene moiety. In bithiophenes, 3, 5, and 8, A. aegypti larvicidal activity increased with increasing number of AcO groups attached to C(3″) or C(4″), indicating that AcO groups may play an important role in the larvicidal activity.
      PubDate: 2014-07-15T05:56:53.597925-05:
      DOI: 10.1002/cbdv.201300290
  • Phytochemical Diversity of the Essential Oils of Mexican Oregano (Lippia
           graveolens Kunth) Populations along an Edapho‐Climatic Gradient
    • Authors: Luz María Calvo‐Irabién; Victor Parra‐Tabla, Violeta Acosta‐Arriola, Fabiola Escalante‐Erosa, Luciana Díaz‐Vera, Gabriel R. Dzib, Luis Manuel Peña‐Rodríguez
      First page: 1010
      Abstract: Mexican oregano (Lippia graveolens) is an important aromatic plant, mainly used as flavoring and usually harvested from non‐cultivated populations. Mexican oregano essential oil showed important variation in the essential‐oil yield and composition. The composition of the essential oils extracted by hydrodistillation from 14 wild populations of L. graveolens growing along an edaphoclimatic gradient was evaluated. Characterization of the oils by GC‐FID and GC/MS analyses allowed the identification of 70 components, which accounted for 89–99% of the total oil composition. Principal component and hierarchical cluster analyses divided the essential oils into three distinct groups with contrasting oil compositions, viz., two phenolic chemotypes, with either carvacrol (C) or thymol (T) as dominant compounds (contents >75% of the total oil composition), and a non‐phenolic chemotype (S) dominated by oxygenated sesquiterpenes. While Chemotype C was associated with semi‐arid climate and shallower and rockier soils, Chemotype T was found for plants growing under less arid conditions and in deeper soils. The plants showing Chemotype S were more abundant in subhumid climate. High‐oil‐yield individuals (>3%) were identified, which additionally presented high percentages of either carvacrol or thymol; these individuals are of interest, as they could be used as parental material for scientific and commercial breeding programs.
      PubDate: 2014-07-15T05:56:54.051306-05:
      DOI: 10.1002/cbdv.201300389
  • Essential‐Oil Composition of Daucus carota ssp. major (Pastinocello
           Carrot) and Nine Different Commercial Varieties of Daucus carota ssp.
           sativus Fruits
    • Authors: Guido Flamini; Elena Cosimi, Pier Luigi Cioni, Ilaria Molfetta, Alessandra Braca
      First page: 1022
      Abstract: The chemical composition of the essential oils obtained by hydrodistillation from the pastinocello carrot, Daucus carota ssp. major (Vis.) Arcang. (flowers and achenes), and from nine different commercial varieties of D. carota L. ssp. sativus (achenes) was investigated by GC/MS analyses. Selective breeding over centuries of a naturally occurring subspecies of the wild carrot, D. carota L. ssp. sativus, has produced the common garden vegetable with reduced bitterness, increased sweetness, and minimized woody core. On the other hand, the cultivation of the pastinocello carrot has been abandoned, even if, recently, there has been renewed interest in the development of this species, which risks genetic erosion. The cultivated carrot (D. carota ssp. sativus) and the pastinocello carrot (D. carota ssp. major) were classified as different subspecies of the same species. This close relationship between the two subspecies urged us to compare the chemical composition of their essential oils, to evaluate the differences. The main essential‐oil constituents isolated from the pastinocello fruits were geranyl acetate (34.2%), α‐pinene (12.9%), geraniol (6.9%), myrcene (4.7%), epi‐α‐bisabolol (4.5%), sabinene (3.3%), and limonene (3.0%). The fruit essential oils of the nine commercial varieties of D. carota ssp. sativus were very different from that of pastinocello, as also confirmed by multivariate statistical analyses.
      PubDate: 2014-07-15T05:56:54.935935-05:
      DOI: 10.1002/cbdv.201300390
  • Suppression of Inflammatory Cytokine Production by ar‐Turmerone
           Isolated from Curcuma phaeocaulis
    • Authors: Sera Oh; A Rheum Han, Hye Ryeon Park, Eun Jung Jang, Hyo Kyeong Kim, Mi Gyeong Jeong, Hyuna Song, Gun Hwa Park, Eun Kyoung Seo, Eun Sook Hwang
      First page: 1034
      Abstract: Rhizomes of Curcuma phaeocaulis Valeton (Zingiberaceae) have traditionally been used for controlling inflammatory conditions. Numerous studies have aimed to isolate and characterize the bioactive constituents of C. phaeocaulis. It has been reported that its anti‐inflammatory properties are a result of cyclooxygenase‐2 inhibition; however, its effect on the T‐cell function remains to be elucidated. In this study, four known sesquiterpenoids, viz., ar‐turmerone (TM), germacrone (GM), (+)‐(4S,5S)‐germacrone‐4,5‐epoxide (GE), and curzerenone (CZ), were isolated from C. phaeocaulis rhizomes and evaluated for their effects on the CD4+ T‐cell function. While GM, GE, and CZ had no effect on the activation of splenic T cells or CD4+ T cells, TM suppressed the interferon (IFN)‐γ production, without affecting the interleukin (IL)‐4 expression. TM also decreased the expression of IL‐2 in CD4+ T cells, but did not change their cell‐division rates upon stimulation. These results suggest that TM, a major constituent of C. phaeocaulis rhizomes selectively exerts potent anti‐inflammatory effects via suppression of the inflammatory cytokines IFN‐γ and IL‐2.
      PubDate: 2014-07-15T05:56:52.21645-05:0
      DOI: 10.1002/cbdv.201300397
  • Leaf n‐Alkanes as Characters Differentiating Coastal and Continental
           Juniperus deltoides Populations from the Balkan Peninsula
    • Authors: Nemanja Rajčević; Pedja Janaćković, Tanja Dodoš, Vele Tešević, Srdjan Bojović, Petar D. Marin
      First page: 1042
      Abstract: The composition of the cuticular n‐alkanes isolated from the leaves of nine populations of Juniperus deltoides R.P.Adams from continental and coastal areas of the Balkan Peninsula was characterized by GC‐FID and GC/MS analyses. In the leaf waxes, 14 n‐alkane homologues with chain‐lengths ranging from C22 to C35 were identified. n‐Tritriacontane (C33) was dominant in the waxes of all populations, but variations between the populations in the contents of all n‐alkanes were observed. Several statistical methods (ANOVA, principal component, discriminant, and cluster analyses) were used to investigate the diversity and variability of the cuticular‐leaf‐n‐alkane patterns of the nine J. deltoides populations. This is the first report on the n‐alkane composition for this species. The multivariate statistical analyses evidenced a high correlation of the leaf‐n‐alkane pattern with the geographical distribution of the investigated samples, differentiating the coastal from the continental populations of this taxon.
      PubDate: 2014-07-15T05:56:54.674113-05:
      DOI: 10.1002/cbdv.201300363
  • Seven New Sesquiterpenoids from the Fruits of Schisandra sphenanthera
    • Authors: Yao‐Ching Tsai; Yuan‐Bin Cheng, I‐Wen Lo, Ho‐Hsi Cheng, Ching‐Jie Lin, Tsong‐Long Hwang, Yuh‐Chi Kuo, Shorong‐Shii Liou, Yi‐Zsau Huang, Yao‐Haur Kuo, Ya‐Ching Shen
      First page: 1053
      Abstract: Fractionation of the EtOH extract from the fruits of Schisandra sphenanthera resulted in the isolation of seven new sesquiterpenoids, 1–7, in addition to the known metabolites 8–23. Among them, schiscupatetralin A (1) possesses an unprecedented structure with a CC bond between cuparenol and tetralin. The isolated new compounds were evaluated for their anti‐HSV‐1 and anti‐inflammatory activities. The results revealed that compound 4 exhibited anti‐HSV‐1 activity, while compound 6 showed a significant anti‐inflammatory activity.
      PubDate: 2014-07-15T05:56:52.46363-05:0
      DOI: 10.1002/cbdv.201300259
  • Electrophysiology Investigation of Trichogin GA IV Activity in Planar
           Lipid Membranes Reveals Ion Channels of Well‐Defined Size
    • Authors: Sorana Iftemi; Marta De Zotti, Fernando Formaggio, Claudio Toniolo, Lorenzo Stella, Tudor Luchian
      First page: 1069
      Abstract: Trichogin GA IV, an antimicrobial peptaibol, exerts its function by augmenting membrane permeability, but the molecular aspects of its pore‐forming mechanism are still debated. Several lines of evidence indicate a ‘barrel‐stave’ channel structure, similar to that of alamethicin, but the length of a trichogin helix is too short to span a normal bilayer. Herein, we present electrophysiology measurements in planar bilayers, showing that trichogin does form channels of a well‐defined size (R=4.2⋅109 Ω; corresponding at least to a trimeric aggregate) that span the membrane and allow ion diffusion, but do not exhibit voltage‐dependent rectification, unlike those of alamethicin.
      PubDate: 2014-07-15T05:56:54.413884-05:
      DOI: 10.1002/cbdv.201300334
  • Halogenated Metabolites Isolated from Penicillium citreonigrum
    • Authors: Wei‐Hua Yuan; Zhi‐Wen Wei, Peng Dai, Hui Wu, Yan‐Xia Zhao, Mei‐Mei Zhang, Nan Jiang, Wei‐Fa Zheng
      First page: 1078
      Abstract: Three chromone analogs, 1–3, a chlorinated alkaloid sclerotioramine (4), together with two 11‐noreremophilane‐type sesquiterpenes with a conjugated enolic OH group and a brominated one, 5 and 6, respectively, were isolated from Penicillium citreonigrum (HQ738282). Compounds 1, 5, and 6 were new. Biological tests revealed that 4 exhibited a significant activity (IC50 7.32 μg/ml), and 6 showed a moderate activity (IC50 16.31 μg/ml) in vitro against HepG2 cell line, and 4 also displayed an activity comparable to that of acarbose against α‐glucosidase.
      PubDate: 2014-07-15T05:56:53.819484-05:
      DOI: 10.1002/cbdv.201300349
  • New Derivatives of Nonactic and Homononactic Acids from Bacillus pumilus
           Derived from Breynia fruticosa
    • Authors: Li Han; Peiyuan Huo, Huahong Chen, Songtao Li, Yi Jiang, Liya Li, Lihua Xu, Chenglin Jiang, Xueshi Huang
      First page: 1088
      Abstract: Six new nonactic and homononactic acid derivatives, ethyl homononactate (1), ethyl nonactate (2), homononactyl homononactate (6), ethyl homononactyl nonactate (7), ethyl homononactyl homononactate (8), and ethyl nonactyl nonactate (9), as well as four known compounds, homononactic acid (3), nonactic acid (4), homononactyl nonactate (5), and bishomononactic acid (10), were isolated from culture broth of Bacillus pumilus derived from Breynia fruticosa. The structures of new compounds were elucidated by spectroscopic analysis and chemical methods. The optical purities of 1–6 were determined by HPLC/MS after treatment with L‐phenylalanine methyl ester. The dimeric compounds 5–9 showed weak cytotoxic activities against five human cancer cell lines (IC50 19–100 μg/ml).
      PubDate: 2014-07-15T05:56:53.037773-05:
      DOI: 10.1002/cbdv.201300350
  • New Isocoumarins from a Cold‐Adapted Fungal Strain Mucor sp. and
           Their Developmental Toxicity to Zebrafish Embryos
    • Authors: Chun‐Chi Feng; Guo‐Dong Chen, Yan‐Qiu Zhao, Sheng‐Chang Xin, Song Li, Jin‐Shan Tang, Xiao‐Xia Li, Dan Hu, Xing‐Zhong Liu, Hao Gao
      First page: 1099
      Abstract: Three new isocoumarin derivatives, mucorisocoumarins A–C (1–3, resp.), together with seven known compounds, 4–10, were isolated from the cold‐adapted fungal strain Mucor sp. (No. XJ07027‐5). The structures of the new compounds were identified by detailed IR, MS, and 1D‐ and 2D‐NMR analyses. It was noteworthy that compounds 1, 2, 4, and 5 were successfully resolved by chiral HPLC, indicating that 1–7 should exist as enantiomers. In an embryonic developmental toxicity assay using a zebrafish model, compound 3 produced developmental abnormalities in the zebrafish embryos. This is the first report of isocoumarins with developmental toxicity to zebrafish embryos.
      PubDate: 2014-07-15T05:56:51.926771-05:
      DOI: 10.1002/cbdv.201400005
  • Bioactive 9,11‐Secosteroids from Gorgonian Subergorgia suberosa
           Collected from the South China Sea
    • Authors: Min Liu; Chang‐Lun Shao, Min Chen, Jun Qi, Yu Wang, Yu‐Chun Fang, Chang‐Yun Wang
      First page: 1109
      Abstract: Five new 9,11‐secosteroids 1, 2, and 4–6, and seven known analogs, 3 and 7–12, with the same steroid skeleton, (5αH)‐3β,6α,11‐trihydroxy‐9,11‐secocholest‐7‐en‐9‐one, were isolated from the South China Sea gorgonian Subergorgia suberosa. Among them, 2/3 and 4/5 are C(24)‐epimeric mixtures, and 6/7 is an (E)/(Z) mixture of (C(24)C(28)). Their structures and relative configurations were elucidated by using comprehensive spectroscopic methods including NOESY spectra. The absolute configuration of the steroidal nucleus was established by the modified Mosher method applied to 10 and on the basis of a common biogenesis for all of these compounds. All isolated compounds, 1–12, and five synthetic acetylated derivatives, 12a–12e, were evaluated for their cytotoxicities in vitro. Compounds 4/5, 11, 12, and 12b–12d showed cytotoxic activities against K562 cell line with the IC50 values ranging from 1.09 to 8.12 μM.
      PubDate: 2014-07-15T05:56:52.772511-05:
      DOI: 10.1002/cbdv.201400021
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