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  Subjects -> CHEMISTRY (Total: 837 journals)
    - ANALYTICAL CHEMISTRY (48 journals)
    - CHEMISTRY (586 journals)
    - CRYSTALLOGRAPHY (22 journals)
    - ELECTROCHEMISTRY (26 journals)
    - INORGANIC CHEMISTRY (41 journals)
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    - PHYSICAL CHEMISTRY (68 journals)

CHEMISTRY (586 journals)                  1 2 3 4 5 6 | Last

2D Materials     Hybrid Journal   (Followers: 5)
Accreditation and Quality Assurance: Journal for Quality, Comparability and Reliability in Chemical Measurement     Hybrid Journal   (Followers: 31)
ACS Catalysis     Full-text available via subscription   (Followers: 27)
ACS Chemical Neuroscience     Full-text available via subscription   (Followers: 16)
ACS Combinatorial Science     Full-text available via subscription   (Followers: 9)
ACS Macro Letters     Full-text available via subscription   (Followers: 20)
ACS Medicinal Chemistry Letters     Full-text available via subscription   (Followers: 24)
ACS Nano     Full-text available via subscription   (Followers: 201)
ACS Photonics     Full-text available via subscription   (Followers: 6)
ACS Synthetic Biology     Full-text available via subscription   (Followers: 11)
Acta Chemica Iasi     Open Access  
Acta Chimica Sinica     Full-text available via subscription  
Acta Chimica Slovaca     Open Access   (Followers: 5)
Acta Chromatographica     Full-text available via subscription   (Followers: 9)
Acta Facultatis Medicae Naissensis     Open Access   (Followers: 1)
Acta Metallurgica Sinica (English Letters)     Hybrid Journal   (Followers: 6)
adhäsion KLEBEN & DICHTEN     Hybrid Journal   (Followers: 5)
Adhesion Adhesives & Sealants     Hybrid Journal   (Followers: 5)
Adsorption Science & Technology     Full-text available via subscription   (Followers: 11)
Advanced Functional Materials     Hybrid Journal   (Followers: 41)
Advanced Science Focus     Free   (Followers: 1)
Advances in Chemical Engineering and Science     Open Access   (Followers: 23)
Advances in Chemical Science     Open Access   (Followers: 9)
Advances in Colloid and Interface Science     Full-text available via subscription   (Followers: 15)
Advances in Drug Research     Full-text available via subscription   (Followers: 17)
Advances in Enzyme Research     Open Access  
Advances in Fluorine Science     Full-text available via subscription   (Followers: 7)
Advances in Fuel Cells     Full-text available via subscription   (Followers: 13)
Advances in Heterocyclic Chemistry     Full-text available via subscription   (Followers: 8)
Advances in Materials Physics and Chemistry     Open Access   (Followers: 15)
Advances in Nanoparticles     Open Access   (Followers: 11)
Advances in Organometallic Chemistry     Full-text available via subscription   (Followers: 9)
Advances in Polymer Science     Hybrid Journal   (Followers: 37)
Advances in Protein Chemistry     Full-text available via subscription   (Followers: 6)
Advances in Protein Chemistry and Structural Biology     Full-text available via subscription   (Followers: 10)
Advances in Quantum Chemistry     Full-text available via subscription   (Followers: 6)
African Journal of Chemical Education     Open Access   (Followers: 1)
African Journal of Pure and Applied Chemistry     Open Access   (Followers: 5)
Afrique Science : Revue Internationale des Sciences et Technologie     Open Access   (Followers: 1)
Agrokémia és Talajtan     Full-text available via subscription   (Followers: 1)
Alkaloids: Chemical and Biological Perspectives     Full-text available via subscription   (Followers: 4)
AMB Express     Open Access  
Ambix     Hybrid Journal   (Followers: 2)
American Journal of Applied Sciences     Open Access   (Followers: 29)
American Journal of Biochemistry and Biotechnology     Open Access   (Followers: 86)
American Journal of Biochemistry and Molecular Biology     Open Access   (Followers: 11)
American Journal of Chemistry     Open Access   (Followers: 19)
American Journal of Plant Physiology     Open Access   (Followers: 10)
American Mineralogist     Full-text available via subscription   (Followers: 7)
Analyst     Full-text available via subscription   (Followers: 37)
Angewandte Chemie     Hybrid Journal   (Followers: 20)
Angewandte Chemie International Edition     Hybrid Journal   (Followers: 134)
Annales UMCS, Chemia     Open Access   (Followers: 2)
Annals of Clinical Chemistry and Laboratory Medicine     Open Access  
Annual Reports in Computational Chemistry     Full-text available via subscription   (Followers: 1)
Annual Reports Section A (Inorganic Chemistry)     Full-text available via subscription   (Followers: 2)
Annual Reports Section B (Organic Chemistry)     Full-text available via subscription   (Followers: 6)
Annual Review of Chemical and Biomolecular Engineering     Full-text available via subscription   (Followers: 10)
Annual Review of Food Science and Technology     Full-text available via subscription   (Followers: 12)
Anti-Infective Agents     Hybrid Journal   (Followers: 1)
Antiviral Chemistry and Chemotherapy     Full-text available via subscription  
Applied Organometallic Chemistry     Hybrid Journal   (Followers: 4)
Applied Spectroscopy     Full-text available via subscription   (Followers: 15)
Applied Surface Science     Hybrid Journal   (Followers: 23)
Arabian Journal of Chemistry     Full-text available via subscription   (Followers: 6)
ARKIVOC     Open Access   (Followers: 1)
Asian Journal of Biochemistry     Open Access   (Followers: 1)
Australian Journal of Chemistry     Hybrid Journal   (Followers: 4)
Autophagy     Full-text available via subscription   (Followers: 2)
Avances en Quimica     Open Access   (Followers: 1)
Biochemical Pharmacology     Hybrid Journal   (Followers: 6)
Biochemistry     Full-text available via subscription   (Followers: 154)
Biochemistry Insights     Open Access   (Followers: 4)
Biochemistry Research International     Open Access   (Followers: 4)
BioChip Journal     Hybrid Journal   (Followers: 1)
Bioinorganic Chemistry and Applications     Open Access   (Followers: 4)
Bioinspired Materials     Open Access  
Biointerface Research in Applied Chemistry     Open Access   (Followers: 1)
Biointerphases     Open Access  
Biomacromolecules     Full-text available via subscription   (Followers: 18)
Biomass Conversion and Biorefinery     Partially Free   (Followers: 6)
Biomedical Chromatography     Hybrid Journal   (Followers: 7)
Biomolecular NMR Assignments     Hybrid Journal   (Followers: 2)
BioNanoScience     Partially Free   (Followers: 4)
Bioorganic & Medicinal Chemistry     Hybrid Journal   (Followers: 29)
Bioorganic & Medicinal Chemistry Letters     Hybrid Journal   (Followers: 23)
Bioorganic Chemistry     Hybrid Journal   (Followers: 5)
Biopolymers     Hybrid Journal   (Followers: 16)
Biosensors     Open Access   (Followers: 3)
Biotechnic and Histochemistry     Hybrid Journal   (Followers: 3)
Boletin de la Sociedad Chilena de Quimica     Open Access  
Bulletin of the Chemical Society of Ethiopia     Open Access   (Followers: 2)
Bulletin of the Chemical Society of Japan     Full-text available via subscription   (Followers: 14)
C - Journal of Carbon Research     Open Access  
Canadian Association of Radiologists Journal     Full-text available via subscription   (Followers: 3)
Canadian Journal of Chemistry     Full-text available via subscription   (Followers: 6)
Canadian Mineralogist     Full-text available via subscription   (Followers: 1)
Carbohydrate Research     Hybrid Journal   (Followers: 11)
Carbon     Hybrid Journal   (Followers: 71)
Catalysis for Sustainable Energy     Open Access   (Followers: 3)

        1 2 3 4 5 6 | Last

Journal Cover   Chemistry & Biodiversity
  [SJR: 0.723]   [H-I: 40]   [5 followers]  Follow
    
   Hybrid Journal Hybrid journal (It can contain Open Access articles)
   ISSN (Print) 1612-1872 - ISSN (Online) 1612-1880
   Published by John Wiley and Sons Homepage  [1609 journals]
  • Contents: C&B 7/2015
    • PubDate: 2015-07-14T08:56:33.747739-05:
      DOI: 10.1002/cbdv.201590008
       
  • Rubrolides as Model for the Development of New Lactones and Their Aza
           Analogs as Potential Photosynthesis Inhibitors
    • Authors: Ulisses A. Pereira; Luiz C. A. Barbosa, Antônio J. Demuner, Antônio A. Silva, Michele Bertazzini, Giuseppe Forlani
      Pages: 987 - 1006
      Abstract: Natural phytotoxins and their synthetic analogs are a potential source of new bioactive compounds for agriculture. Analogs of rubrolides, a class of γ‐alkylidene‐γ‐lactones isolated from different ascidians, have been shown to interfere with the photosynthetic electron‐transport chain, yet their activity needs to be improved. With this aim, ten 5‐aryl‐6‐benzyl‐4‐bromopyridazin‐3(2H)‐ones were prepared in yields ranging from 44 to 88% by reaction of their correspondent γ‐alkylidene‐γ‐lactones with NH2NH2. The structures of these rubrolide analogs were determined by 1H‐ and 13C‐NMR, 2D‐NMR (COSY and HETCOR), NOE difference, and MS techniques. These compounds were evaluated for their abilities of interfering with the light‐driven reduction of ferricyanide by isolated spinach chloroplasts. Lactones with electron‐withdrawing substituents in the para‐position of the benzylidene ring were the most effective inhibitors. Characterization of the activity of 11b/11b′ suggested a mechanism based on the interaction with the plastoquinone binding site of photosystem II. Addition of several compounds to the culture medium of a cyanobacterial model strain was found to inhibit algal growth. However, the relative effectiveness was not consistent with their activity in vitro, suggesting the occurrence of multiple targets and/or detoxyfication mechanisms. Indeed, the compounds showed differential effects on the heterotrophic growth of some crop species, Cucumis sativus and Sorghum bicolor. Pyridazin‐3(2H)‐ones 12e, 12i, and 12j, which have been found poorly active against the photosynthetic electron transport, were the most effective in inhibiting the growth of some weeds, Ipomoea grandifolia and Brachiaria decumbens, under greenhouse conditions.
      PubDate: 2015-07-14T08:56:31.499319-05:
      DOI: 10.1002/cbdv.201400416
       
  • The Impact of Model Peptides on Structural and Dynamic Properties of Egg
           Yolk Lecithin Liposomes – Experimental and DFT Studies
    • Authors: Roksana Wałęsa; Dariusz Man, Grzegorz Engel, Dawid Siodłak, Teobald Kupka, Tomasz Ptak, Małgorzata A. Broda
      Pages: 1007 - 1024
      Abstract: Electron spin resonance (ESR), 1H‐NMR, voltage and resistance experiments were performed to explore structural and dynamic changes of Egg Yolk Lecithin (EYL) bilayer upon addition of model peptides. Two of them are phenylalanine (Phe) derivatives, Ac‐Phe‐NHMe (1) and Ac‐Phe‐NMe2 (2), and the third one, Ac‐(Z)‐ΔPhe‐NMe2 (3), is a derivative of (Z)‐α,β‐dehydrophenylalanine. The ESR results revealed that all compounds reduced the fluidity of liposome's membrane, and the highest activity was observed for compound 2 with N‐methylated C‐terminal amide bond (Ac‐Phe‐NMe2). This compound, being the most hydrophobic, penetrates easily through biological membranes. This was also observed in voltage and resistance studies. 1H‐NMR studies provided a sound evidence on H‐bond interactions between the studied diamides and lecithin polar head. The most significant changes in H‐atom chemical shifts and spin‐lattice relaxation times T1 were observed for compound 1. Our experimental studies were supported by theoretical calculations. Complexes EYLAc‐Phe‐NMe2 and EYLAc‐(Z)‐ΔPhe‐NMe2, stabilized by NH⋅⋅⋅O or/and CH⋅⋅⋅O H‐bonds were created and optimized at M06‐2X/6‐31G(d) level of theory in vacuo and in H2O environment. According to our molecular‐modeling studies, the most probable lecithin site of H‐bond interaction with studied diamides is the negatively charged O‐atom in phosphate group which acts as H‐atom acceptor. Moreover, the highest binding energy to hydrocarbon chains were observed in the case of Ac‐Phe‐NMe2 (2).
      PubDate: 2015-07-14T08:56:32.397898-05:
      DOI: 10.1002/cbdv.201400179
       
  • Essential Oils and Chemical Diversity of Southeast European Populations of
           Salvia officinalis L.
    • Authors: Ivana Cvetkovikj; Gjoshe Stefkov, Marija Karapandzova, Svetlana Kulevanova, Zlatko Satović
      Pages: 1025 - 1039
      Abstract: The essential oils of 25 populations of Dalmatian sage (Salvia officinalis L.) from nine Balkan countries, including 17 indigenous populations (representing almost the entire native distribution area) and eight non‐indigenous (cultivated or naturalized) populations were analyzed. Their essential‐oil yield ranged from 0.25 to 3.48%. Within the total of 80 detected compounds, ten (β‐pinene, 1,8‐cineole, cis‐thujone, trans‐thujone, camphor, borneol, trans‐caryophyllene, α‐humulene, viridiflorol, and manool) represented 42.60 to 85.70% of the components in the analyzed essential oils. Strong positive correlations were observed between the contents of trans‐caryophyllene and α‐humulene, α‐humulene and viridiflorol, and viridiflorol and manool. Principal component analysis (PCA) on the basis of the contents of the ten main compounds showed that four principal components had an eigenvalue greater than 1 and explained 79.87% of the total variation. Performing cluster analysis (CA), the sage populations could be grouped into four distinct chemotypes (A–D). The essential oils of 14 out of the 25 populations of Dalmatian sage belonged to Chemotype A and were rich in cis‐thujone and camphor, with low contents of trans‐thujone. The correlation between the essential‐oil composition and geographic variables of the indigenous populations was not significant; hence, the similarities in the essential‐oil profile among populations could not be explained by the physical proximity of the populations. Additionally, the southeastern populations tended to have higher EO yields than the northwestern ones.
      PubDate: 2015-07-14T08:56:30.405359-05:
      DOI: 10.1002/cbdv.201400273
       
  • Identification and Antifeedant Activities of Limonoids from Azadirachta
           indica
    • Authors: Yu‐Xin Yan; Jie‐Qing Liu, Hong‐Wei Wang, Jin‐Xiong Chen, Jian‐Chao Chen, Li Chen, Lin Zhou, Ming‐Hua Qiu
      Pages: 1040 - 1046
      Abstract: Four new limonoids, azadiraindins A–D (1–4, resp.), together with seven known analogs, were isolated from the MeOH extract of Azadirachta indica. The structures of 1–4 were elucidated by NMR and MS spectroscopic analyses, and the relative configuration of 1 was determined by single‐crystal X‐ray crystallography. The compounds isolated in comparatively large amount were evaluated for their antifeedant activities against Plutella xylostella; the antifeedant rate of 10 was 90.6% and the corrected mortality of 8 was 79.2%.
      PubDate: 2015-07-14T08:56:34.138968-05:
      DOI: 10.1002/cbdv.201400282
       
  • Antioxidant Capacity and Chemical Profiles of Satureja montana L. Honey:
           Hotrienol and Syringyl Derivatives as Biomarkers
    • Authors: Igor Jerković; Carlo I. G. Tuberoso, Zvonimir Marijanović, Marina Kranjac, M. Malenica‐Staver
      Pages: 1047 - 1056
      Abstract: The present study is focused on the antioxidant capacity and chemical profiling of eight Croatian Satureja montana L. honey samples. Among the 20 compounds obtained by headspace solid‐phase microextraction (HS‐SPME) and identified by GC‐FID and GC/MS analyses, hotrienol was predominant (75.9–81.7%). The honey matrix volatile/semivolatile profile was investigated by ultrasonic solvent extraction (USE) followed by GC‐FID and GC/MS analyses. The major compounds identified by this latter method were the sinapic‐acid derivatives methyl syringate (36.2–72.8%) and syringaldehyde (2.2–43.1%). Direct, targeted HPLC‐DAD analyses of the native honey samples revealed the presence of methyl syringate (7.10–39.60 mg/kg) and syringic acid (0.10–1.70 mg/kg). In addition, the total phenolic content of the samples was determined by the FolinCiocalteu assay (311.0–465.9 mg GAE/kg), and the antioxidant capacity was evaluated by the DPPH radical‐scavenging activity (0.5–1.0 mmol TEAC/kg) and the ferric reducing antioxidant power (2.5–5.1 mmol Fe2+/kg).
      PubDate: 2015-07-14T08:56:33.807107-05:
      DOI: 10.1002/cbdv.201400183
       
  • Biological Evaluation of Secondary Metabolites from the Root of Machilus
           obovatifolia
    • Authors: Shan‐Yu Lin; Horng‐Huey Ko, Shiow‐Ju Lee, Hsun‐Shuo Chang, Chu‐Hung Lin, Ih‐Sheng Chen
      Pages: 1057 - 1067
      Abstract: Bioassay‐guided fractionation of the root of Machilus obovatifolia led to the isolation of four new lignans, epihenricine B (1), threo‐(7′R,8′R) and threo‐(7′S,8′S)‐methylmachilusol D (2 and 3), and isofragransol A (4), along with 23 known compounds. The compounds were obtained as isomeric mixtures (i.e., 2/3 and 4/20, resp.). The structures were elucidated by spectral analyses. Among the isolates, 1, licarin A (12), guaiacin (14), (±)‐syringaresinol (21), and (−)‐epicatechin (23) showed ABTS (=2,2′‐azinobis(3‐ethylbenzothiazoline‐6‐sulfonic acid) cation radical‐scavenging activity, with SC50 values of 11.7±0.5, 12.3±1.1, 11.0±0.1, 10.6±0.3, and 9.5±0.2 μM in 20 min, respectively. In addition, kachirachirol B (17) showed cytotoxicity against the NCI‐H460 cell line with an IC50 value of 3.1 μg/ml.
      PubDate: 2015-07-14T08:56:30.080175-05:
      DOI: 10.1002/cbdv.201400196
       
  • Antibacterial Δ1‐3‐Ketosteroids from the South China Sea
           Gorgonian Coral Subergorgia rubra
    • Authors: Xue‐Ping Sun; Fei Cao, Chang‐Lun Shao, Mei Wang, Xiu‐Li Zhang, Chang‐Yun Wang
      Pages: 1068 - 1074
      Abstract: Three new Δ1‐3‐ketosteroids characterized with a 9‐OH, subergosterones A–C (1–3), together with five known analogs 4–8, were obtained from the gorgonian coral Subergorgia rubra collected from the South China Sea. The structures of 1–3, including their absolute configurations, were determined by comprehensive spectroscopic methods and electronic circular dichroism (ECD) experiments. Compounds 2 and 3 exhibited inhibitory antibacterial activities against Bacillus cereus with MIC values of 1.56 μM.
      PubDate: 2015-07-14T08:56:32.864964-05:
      DOI: 10.1002/cbdv.201400217
       
  • Wild Sicilian Rosemary: Phytochemical and Morphological Screening and
           Antioxidant Activity Evaluation of Extracts and Essential Oils
    • Authors: Edoardo M. Napoli; Laura Siracusa, Antonella Saija, Antonio Speciale, Domenico Trombetta, Teresa Tuttolomondo, Salvatore La Bella, Mario Licata, Giuseppe Virga, Raffaele Leone, Claudio Leto, Laura Rubino, Giuseppe Ruberto
      Pages: 1075 - 1094
      Abstract: To identify the best biotypes, an extensive survey of Sicilian wild rosemary was carried out by collecting 57 samples from various sites, followed by taxonomic characterization from an agronomic perspective. All the biotypes collected were classified as Rosmarinus officinalis L. A cluster analysis based on the morphological characteristics of the plants allowed the division of the biotypes into seven main groups, although the characteristics examined were found to be highly similar and not area‐dependent. Moreover, all samples were analyzed for their phytochemical content, applying an extraction protocol to obtain the nonvolatile components and hydrodistillation to collect the essential oils for the volatile components. The extracts were characterized by LC‐UV‐DAD/ESI‐MS, and the essential oils by GC‐FID and GC/MS analyses. In the nonvolatile fractions, 18 components were identified, namely, 13 flavones, two organic acids, and three diterpenes. In the volatile fractions, a total of 82 components were found, with as predominant components α‐pinene and camphene among the monoterpene hydrocarbons and 1,8‐cineole, camphor, borneol, and verbenone among the oxygenated monoterpenes. Cluster analyses were carried out on both phytochemical profiles, allowing the separation of the rosemary samples into different chemical groups. Finally, the total phenol content and the antioxidant activity of the essential oils and extracts were determined with the Folin–Ciocalteu (FC) colorimetric assay, the UV radiation‐induced peroxidation in liposomal membranes (UV‐IP test), and the scavenging activity of the superoxide radical (O$\rm{{_{2}^{{^\cdot} -}}}$). The present study confirmed that the essential oils and organic extracts of the Sicilian rosemary samples analyzed showed a considerable antioxidant/free radical‐scavenging activity.
      PubDate: 2015-07-14T08:56:31.06822-05:0
      DOI: 10.1002/cbdv.201400274
       
  • New Metabolites from Endolichenic Fungus Pleosporales sp.
    • Authors: Yang Jiao; Gang Li, Hai‐Ying Wang, Jing Liu, Xiao‐Bin Li, Lu‐Lu Zhang, Zun‐Tian Zhao, Hong‐Xiang Lou
      Pages: 1095 - 1104
      Abstract: Eight new metabolites were obtained from the culture of an endolichenic fungus, Pleosporales sp. Their structures were determined as three terphenyl derivatives, cucurbitarins A–C (1–3, resp.), two structurally related compounds, cucurbitarins D and E (4 and 5, resp.), two benzocoumarins, 3,10‐dihydroxy‐4,8‐dimethoxy‐6‐methylbenzocoumarin (6) and 3,8,10‐trihydroxy‐4‐methoxy‐6‐methylbenzocoumarin (7), as well as one cyclohexenone, (5R)‐5‐hydroxy‐2,3‐dimethylcyclohex‐2‐en‐1‐one (8), based on the spectroscopic data.
      PubDate: 2015-07-14T08:56:33.240736-05:
      DOI: 10.1002/cbdv.201400279
       
  • Anthelmintic Effects of the Essential Oil of Fennel (Foeniculum vulgare
           Mill., Apiaceae) against Schistosoma mansoni
    • Authors: Kamila A. L. Wakabayashi; Nathalya I. de Melo, Daniela P. Aguiar, Pollyanna F. de Oliveira, Milton Groppo, Ademar A. da Silva Filho, Vanderlei Rodrigues, Wilson R. Cunha, Denise C. Tavares, Lizandra G. Magalhães, Antônio E. M. Crotti
      Pages: 1105 - 1114
      Abstract: Foeniculum vulgare Mill. (Apiaceae), known as fennel, is a widespread aromatic herbaceous plant, and its essential oil is used as additive in the food, pharmaceutical, cosmetic, and perfume industries. The in vitro antischistosomal activity and cytotoxic effects against V79 cells of the essential oil of F. vulgare cultivated in southeastern Brazil (FV‐EO) was investigated. The FV‐EO was obtained by hydrodistillation and characterized by GC‐FID and GC/MS analyses. (E)‐Anethole (69.8%) and limonene (22.5%) were identified as the major constituents. Its anthelmintic activity against Schistosoma mansoni was evaluated at concentrations of 10, 50, and 100 μg/ml, and it was found to be active against adult S. mansoni worms, although it was less effective than the positive control praziquantel (PZQ) in terms of separation of the coupled pairs, mortality, and decreased motor activity. However, FV‐EO elicited an interesting dose‐dependent reduction in the number of S. mansoni eggs. On their own, (E)‐anethole and the limonene enantiomers were much less effective than FV‐EO and PZQ. An XTT‐cytotoxicity‐based assay evidenced no FV‐EO cytotoxicity against V79 cells. In summary, FV‐EO displayed moderate in vitro schistosomicidal activity against adult S. mansoni worms, exerted remarkable inhibitory effects on the egg development, and was of low toxicity.
      PubDate: 2015-07-14T08:56:30.741718-05:
      DOI: 10.1002/cbdv.201400293
       
  • A Novel Jaspine BCeramide Hybrid Modulates Sphingolipid Metabolism
    • Authors: Virginie Garcia; Pauline Le Faouder, Aude Dupuy, Thierry Levade, Stéphanie Ballereau, Yves Génisson
      Pages: 1115 - 1125
      Abstract: A new sphingolipid hybrid molecule was designed to assemble, within a tail‐to‐tail double‐chain structure, the ceramide hydrophilic moiety and the tetrahydrofuran pharmacophore of jaspine B, a natural product known to interfere with sphingolipid metabolism. This compound was prepared through acylation of sphingosine with a jaspine B derivative bearing a COOH group in the terminal position of the aliphatic backbone. This new hybrid molecule was evaluated for its capacities to affect melanoma cell viability and sphingolipid metabolism. While retaining the cytotoxicity of ceramide itself, this compound was shown to lower the sphingomyelin cellular levels and significantly enhance the production of sphingosine‐1‐phosphate, thus representing a novel sphingolipid metabolism modulator.
      PubDate: 2015-07-14T08:56:31.967037-05:
      DOI: 10.1002/cbdv.201400357
       
  • Polygonifoliol, a New Tirucallane Triterpene from the Latex of the Seaside
           Sandmat Euphorbia polygonifolia
    • Authors: José‐Luis Giner; Timothy N. Schroeder
      Pages: 1126 - 1129
      Abstract: The genus Euphorbia contains over 2000 species which exhibit a considerable diversity of di‐ and triterpenes in their latex. The North American species Euphorbia polygonifolia is a low growing plant of Atlantic and Great Lake beaches. The composition of its free and esterified triterpene alcohols was determined by HPLC and 1H‐NMR analyses. An unreported triterpene alcohol was found as 2.6% and 10.3% of the free and esterified fractions, respectively. The structure of the new triterpene alcohol was determined using HMBC, and its configurational assignment was secured by acid‐catalyzed isomerization to isotirucallol. The new compound, polygonifoliol, was shown to be Δ12‐isotirucallol.
      PubDate: 2015-07-14T08:56:33.061151-05:
      DOI: 10.1002/cbdv.201400426
       
  • Erratum: Bioactive Diphenyl Ether Derivatives from a
           Gorgonian‐Derived Fungus Talaromyces sp.
    • Authors: Min Chen; Lei Han, Chang‐Lun Shao, Zhi‐Gang She, Chang‐Yun Wang
      Pages: 1130 - 1130
      PubDate: 2015-07-14T08:56:32.316432-05:
      DOI: 10.1002/cbdv.201590007
       
 
 
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