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Chemical Science
Journal Prestige (SJR): 4.508  Citation Impact (citeScore): 9 Number of Followers: 28  Open Access journalISSN (Print) 1478-6524 - ISSN (Online) 2041-6520 Published by RSC  [44 journals]
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- Hybrid Mass Spectrometry Methods Reveal Lot-to-Lot Differences and
Delineate the Effects of Glycosylation on the Tertiary Structure of
Herceptin
Abstract: Chem. Sci., 2019, Accepted Manuscript
DOI : 10.1039/C8SC05029E, Edge Article
Open Access 
This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Rosie Upton, Lukasz G. Migas, Kamila J Pacholarz, Richard G. Beniston, Shirley Peters, Rachel Davis, Sian Estdale, David Firth, Perdita Barran
To quantify the measurable variations in the structure of a biopharmaceutical product we systematically evaluate three lots of Herceptin®, two mAb standards and an intact Fc-hinge fragment. Each mAb is...
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- Oxygen reactions on Pt{hkl} in a non-aqueous Na+ electrolyte: Site
selective stabilization of a sodium peroxy species
Abstract: Chem. Sci., 2019, Accepted Manuscript
DOI : 10.1039/C8SC05489D, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Thomas Galloway, Gary Attard, Jinchao Dong, Jian-Feng Li, Laurence Hardwick
Sodium-oxygen battery cathodes utilise the reversible redox species of oxygen in the presence of sodium ions. However the oxygen reduction and evolution reaction mechanism is yet to be conclusively determined....
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- Ionic polypeptide tags for protein phase separation
Abstract:Chem. Sci., 2019, Advance Article
DOI : 10.1039/C8SC04253E, Edge Article Open Access 
This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Rachel A. Kapelner, Allie C. Obermeyer
Short ionic polypeptide tags were demonstrated to drive complex coacervation of globular proteins at physiological conditions while maintaining protein activity.
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- Catalytic β C–H amination via an imidate radical relay
Abstract:Chem. Sci., 2019, Advance Article
DOI : 10.1039/C8SC05685D, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Leah M. Stateman, Ethan A. Wappes, Kohki M. Nakafuku, Kara M. Edwards, David A. Nagib
An iodine-catalyzed strategy for β C–H amination of alcohols is enabled by a chemo-, regio-, and stereo-selective H-atom transfer mechanism.
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- CO2 Capture by Mn(I) and Re(I) Complexes with a Deprotonated
Triethanolamine Ligand
Abstract: Chem. Sci., 2019, Accepted Manuscript
DOI : 10.1039/C8SC04389B, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Hiroki Koizumi, Hiroyuki Chiba, Ayumi Sugihara, Munetaka Iwamura, Koichi Nozaki, Osamu Ishitani
CO2 capture at low concentration of CO2 by catalysts is potentially useful for developing photocatalytic and electrocatalytic CO2 reduction systems. We investigated tha CO2-capturing abilities of two complexes, fac-Mn(X2bpy)(CO)3(OCH2CH2NR2) and...
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- Chiral Cyclopentadienyl RhIII-Catalyzed Enantioselective Cyclo-propanation
of Electron-Deficient Olefins Enable Rapid Access to UPF-648 and Oxypilin
Natural Products
Abstract: Chem. Sci., 2019, Accepted Manuscript
DOI : 10.1039/C8SC05702H, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Coralie Duchemin, Nicolai Cramer
Chiral cyclopentadienyl RhIII complexes efficiently catalyze enantioselective cyclopropanations of electron-deficient olefins with N-enoxysuccinimides as the C1 unit. Excellent asymmetric inductions and high diastereoselectivities can be obtained for wide range of...
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- Catalytic Asymmetric Allylation of Aldehydes with Alkenes through Allylic
C(sp3)‒H Functionalization Mediated by Organophotoredox and Chiral
Chromium Hybrid Catalysis
Abstract: Chem. Sci., 2019, Accepted Manuscript
DOI : 10.1039/C8SC05677C, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Harunobu Mitsunuma, Shun Tanabe, Hiromu Fuse, Kei Ohkubo, Motomu Kanai
We describe a hybrid system that realizes cooperativity between an organophotoredox acridinium catalyst and a chiral chromium complex catalyst, thereby enabling unprecedented exploitation of unactivated hydrocarbon alkenes as precursors to...
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- In Situ Visualization of Ozone in the Brains of Mice with Depression
Phenotypes by a New Near-Infrared Fluorescence Probe
Abstract: Chem. Sci., 2019, Accepted Manuscript
DOI : 10.1039/C8SC04891F, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Ping Li, Jijuan Wang, Xin Wang, Qi Ding, Xiaoyi Bai, Yandi Zhang, Di Su, Wei Zhang, Wen Zhang, Bo Tang
Ozone (O3), one of reactive oxygen species (ROS), is deeply involved in diseases including depression. However, the lack of proper in situ detection methods suitable for complex biological context of...
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- Population Analysis to Increase the Robustness of Molecular Computational
Identification and its Extension into the Near-infrared for Substantial
Numbers of Small Objects
Abstract: Chem. Sci., 2019, Accepted Manuscript
DOI : 10.1039/C8SC05548C, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.A P De Silva, Chaoyi Yao, Jue Ling, Linyihong Chen
The first population analysis is presented for submillimetric polymer beads which are tagged with five multi-valued logic gates, YES, 2YES + PASS 1, YES + PASS 1, YES + 2PASS...
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- Retro Baeyer–Villiger Reaction: Electrochemical Reduction of
[60]Fullerene-Fused Lactones to [60]Fullerene-Fused Ketones
Abstract: Chem. Sci., 2019, Accepted Manuscript
DOI : 10.1039/C8SC05089A, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Chuang Niu, Dian-Bing Zhou, Yong Yang, Zheng-Chun Yin, Guan-Wu Wang
A highly efficient electrochemical reduction of [60]fullerene-fused lactones to [60]fullerene-fused ketones, a formal process of retro Baeyer–Villiger reaction, has been achieved for the first time. The electrochemically generated dianionic [60]fullerene-fused...
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- Heterolytic Bond Activation at Gold: Evidence for Gold(III) H-B, H-Si
Complexes, H-H and H-C Cleavage
Abstract: Chem. Sci., 2019, Accepted Manuscript
DOI : 10.1039/C8SC05229H, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Luca Rocchigiani, Peter H.M. Budzelaar, Manfred Bochmann
The coordinatively unsaturated gold(III) chelate complex [(C^N-CH)Au(C6F5)]+ (1+) reacts with main group hydrides H-BPin and H-SiEt3 in dichloromethane solution at 70 °C to form the corresponding σ-complexes, which were spectroscopically...
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- Fine-tuning of wettability in a single metal–organic framework via
postcoordination modification and its reduced graphene oxide aerogel for
oil–water separation
Abstract:Chem. Sci., 2019, Advance Article
DOI : 10.1039/C8SC04581J, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Sunhwi Eom, Dong Won Kang, Minjung Kang, Jong Hyeak Choe, Hyojin Kim, Dae Won Kim, Chang Seop Hong
Postcoordination modification of Mg2(dobpdc) with monoamines of various alkyl chain lengths enables facile fine-tuning of wettability and efficient oil–water separation.
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- A universal method for sensitive and cell-free detection of
CRISPR-associated nucleases
Abstract:Chem. Sci., 2019, Advance Article
DOI : 10.1039/C8SC03426E, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Kurt J. Cox, Hari K. K. Subramanian, Christian Cuba Samaniego, Elisa Franco, Amit Choudhary
We report a universal assay for sensitive, cell-free detection of CRISPR-associated nucleases by coupling activity to a fluorescent transcription product.
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- WO3/BiVO4: impact of charge separation at the timescale of water oxidation
Abstract:Chem. Sci., 2019, Advance Article
DOI : 10.1039/C8SC04679D, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Shababa Selim, Laia Francàs, Miguel García-Tecedor, Sacha Corby, Chris Blackman, Sixto Gimenez, James R. Durrant, Andreas Kafizas
Unveiling the role of applied bias on the charge carrier dynamics in the WO3/BiVO4 junction during water oxidation.
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- Perfluoroalkylative Pyridylation of Alkenes via 4-Cyanopyridine-Boryl
Radicals
Abstract: Chem. Sci., 2019, Accepted Manuscript
DOI : 10.1039/C8SC05237A, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Jia Cao, guoqiang wang, liuzhou gao, Hui Chen, Xue ting Liu, Cheng Xu, Shuhua Li
A metal-free and photo-free method for the perfluoroalkylative pyridylation of alkenes has been developed via a combination of computational and experimental studies. Density functional theory calculations and control experiments indicate...
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- Light Emission Enhancement by Supramolecular Complexation of
Chemiluminescence Probes Designed for Bioimaging
Abstract: Chem. Sci., 2019, Accepted Manuscript
DOI : 10.1039/C8SC05174G, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Samer Gnaim, Anna Scomparin, Anat Eldar Boock, Christoph Ruediger Bauer, Ronit Satchi-Fainaro, Doron Shabat
Chemiluminescence offers advantages over fluorescence for bioimaging, since an external light source is unnecessary with chemiluminescent agents. This report demonstrates the first encapsulation of chemiluminescence phenoxy-adamantyl-1,2-dioxetane probes with trimethyl β-cyclodextrin....
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- Achieving an Exceptionally High Loading of Isolated Cobalt Single Atoms on
Porous Carbon Matrix for Efficient Visible-Light-Driven Photocatalytic
Hydrogen Production
Abstract: Chem. Sci., 2019, Accepted Manuscript
DOI : 10.1039/C8SC05540H, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Rui Shi, Chengcheng Tian, Xiang Zhu, Cheng-Yun Peng, Bingbao Mei, Lin He, Xianlong Du, Zheng Jiang, Yong Chen, Sheng Dai
Single-atom catalysts (SACs) have shown great potential in a wide variety of chemical reactions and become the most active new frontier in catalysis due to the maximum efficiency of metal...
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- Highly reversible potassium-ion intercalation in tungsten disulfide
Abstract:Chem. Sci., 2019, Advance Article
DOI : 10.1039/C8SC04350G, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Ruding Zhang, Jingze Bao, Yilong Pan, Chuan-Fu Sun
0.62 K+ readily (de)intercalates in WS2 with well-defined voltage plateaus, an intrinsically safe operation potential, and ultrahigh reversibility.
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- Correction: Thermoreversible crystallization-driven aggregation of diblock
copolymer nanoparticles in mineral oil
Abstract: Chem. Sci., 2019, 10,947-947
DOI : 10.1039/C8SC90241K, Correction Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Matthew J. Derry, Oleksandr O. Mykhaylyk, Anthony J. Ryan, Steven P. Armes
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- Comment on Enantioselective total synthesis of (−)-colchicine,
(+)-demecolcinone and metacolchicine: determination of the absolute
configurations of the latter two alkaloids by B. Chen, X. Liu, Y.-J. Hu,
D.-M. Zhang, L. Deng, J. Lu, L. Min, W.-C. Ye and C.-C. Li, Chem. Sci.,
2017, 8, 4961–4966
Abstract:Chem. Sci., 2019, 10,943-945
DOI : 10.1039/C8SC90247J, Comment Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Reinhard W. Hoffmann, Hans-Günther Schmalz, Ulrich Koert, Gregory K. Pierens
We note that some features of the NMR spectra deposited for the purported isomeric metacolchicines are not compatible with the assignment of those isomers as being atrop-diastereomers.
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- Correction: Enantioselective total synthesis of (−)-colchicine,
(+)-demecolcinone and metacolchicine: determination of the absolute
configurations of the latter two alkaloids
Abstract: Chem. Sci., 2019, 10,946-946
DOI : 10.1039/C8SC90249F, Correction Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Bo Chen, Xin Liu, Ya-Jian Hu, Dong-Mei Zhang, Lijuan Deng, Jieyu Lu, Long Min, Wen-Cai Ye, Chuang-Chuang Li
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- Emergence of high ORR activity through controlling local density-of-states
by alloying immiscible Au and Ir
Abstract:Chem. Sci., 2019, 10,652-656
DOI : 10.1039/C8SC04135K, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Kohei Kusada, Dongshuang Wu, Tomokazu Yamamoto, Takaaki Toriyama, Syo Matsumura, Wei Xie, Michihisa Koyama, Shogo Kawaguchi, Yoshiki Kubota, Hiroshi Kitagawa
Although Ir or Au is not active for ORR, we first demonstrate highly active Au0.5Ir0.5 alloy by emulating Pt LDOS profile.
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- Lytic reactions of drugs with lipid membranes
Abstract:Chem. Sci., 2019, 10,674-680
DOI : 10.1039/C8SC04831B, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Hannah M. Britt, Clara A. García-Herrero, Paul W. Denny, Jackie A. Mosely, John M. Sanderson
The involvement of drugs in direct chemical reactions with lipids may be linked to toxic effects in liver cell lines.
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- Nanobowls with controlled openings and interior holes driven by the
synergy of hydrogen bonding and π–π interaction
Abstract:Chem. Sci., 2019, 10,657-664
DOI : 10.1039/C8SC03995J, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Hui Sun, Danqing Liu, Jianzhong Du
Nanobowls with controlled openings and interior holes are created by self-assembly of homopolymers with hydrogen bonding and π–π interaction.
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- The anti-apoptotic proteins NAF-1 and iASPP interact to drive apoptosis in
cancer cells
Abstract:Chem. Sci., 2019, 10,665-673
DOI : 10.1039/C8SC03390K, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Anat Iosub-Amir, Fang Bai, Yang-Sung Sohn, Luhua Song, Sagi Tamir, Henri-Baptiste Marjault, Guy Mayer, Ola Karmi, Patricia A. Jennings, Ron Mittler, José N. Onuchic, Assaf Friedler, Rachel Nechushtai
We reveal a novel interaction between the two anti-apoptotic proteins iASPP and NAF-1, which are overexpressed in many types of cancer cells, and propose that this interaction is required for apoptosis activation in cancer cells. A peptide derived from the interaction interface inhibits apoptosis in cells.
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- Reduction of CO2 by a masked two-coordinate cobalt(I) complex and
characterization of a proposed oxodicobalt(II) intermediate
Abstract:Chem. Sci., 2019, 10,918-929
DOI : 10.1039/C8SC02599A, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Lisa Roy, Malik H. Al-Afyouni, Daniel E. DeRosha, Bhaskar Mondal, Ida M. DiMucci, Kyle M. Lancaster, Jason Shearer, Eckhard Bill, William W. Brennessel, Frank Neese, Shengfa Ye, Patrick L. Holland
The detailed mechanism of CO2 reduction by a cobalt(I) complex is investigated using computations and kinetics.
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- Probing surfaces of atmospherically relevant organic particles by easy
ambient sonic-spray ionization mass spectrometry (EASI-MS)
Abstract:Chem. Sci., 2019, 10,884-897
DOI : 10.1039/C8SC03851A, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.L. M. Wingen, B. J. Finlayson-Pitts
EASI-MS is a promising technique for probing the chemical structures of inhomogeneous airborne organic particles.
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- A general approach for the site-selective modification of native proteins,
enabling the generation of stable and functional antibody–drug
conjugates
Abstract:Chem. Sci., 2019, 10,694-700
DOI : 10.1039/C8SC04645J, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Stephen J. Walsh, Soleilmane Omarjee, Warren R. J. D. Galloway, Terence T.-L. Kwan, Hannah F. Sore, Jeremy S. Parker, Marko Hyvönen, Jason S. Carroll, David R. Spring
Divinylpyrimidine (DVP) linkers enable access to highly stable and functional antibody–drug conjugates.
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- Nickel-catalyzed allylic defluorinative alkylation of trifluoromethyl
alkenes with reductive decarboxylation of redox-active esters
Abstract:Chem. Sci., 2019, 10,809-814
DOI : 10.1039/C8SC04335C, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Xi Lu, Xiao-Xu Wang, Tian-Jun Gong, Jing-Jing Pi, Shi-Jiang He, Yao Fu
Synthesis of functionalized gem-difluoroalkenes was achieved through nickel-catalyzed allylic defluorinative alkylation of trifluoromethyl alkenes with reductive decarboxylation of redox-active esters.
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- Two-photon fluorescence imaging reveals a Golgi apparatus superoxide
anion-mediated hepatic ischaemia-reperfusion signalling pathway
Abstract:Chem. Sci., 2019, 10,879-883
DOI : 10.1039/C8SC03917H, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Wen Zhang, Jiao Zhang, Ping Li, Jihong Liu, Di Su, Bo Tang
We developed a two-photon fluorescence probe for the dynamic and reversible detection of O2˙− levels in the Golgi apparatus.
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- Determination of the structure and geometry of N-heterocyclic carbenes on
Au(111) using high-resolution spectroscopy
Abstract:Chem. Sci., 2019, 10,930-935
DOI : 10.1039/C8SC03502D, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Giacomo Lovat, Evan A. Doud, Deyu Lu, Gregor Kladnik, Michael S. Inkpen, Michael L. Steigerwald, Dean Cvetko, Mark S. Hybertsen, Alberto Morgante, Xavier Roy, Latha Venkataraman
The geometry and bonding of N-heterocyclic carbenes to metal surfaces depends on the substituents on the N-atoms.
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- Selective electrochemical functionalization of the graphene edge
Abstract:Chem. Sci., 2019, 10,936-942
DOI : 10.1039/C8SC04083D, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Anur Yadav, Rodrigo M. Iost, Tilmann J. Neubert, Sema Baylan, Thomas Schmid, Kannan Balasubramanian
We report the direct exclusive modification of the edge of a single graphene monolayer with nanoparticles or organic functionalities under ambient conditions.
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- X-ray Raman optical activity of chiral molecules
Abstract:Chem. Sci., 2019, 10,898-908
DOI : 10.1039/C8SC04120B, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Jérémy R. Rouxel, Yu Zhang, Shaul Mukamel
Resonant and off-resonant Raman Optical Activity signals in the X-ray regime (XROA) are predicted.
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- Do water's electrons care about electrolytes'
Abstract:Chem. Sci., 2019, 10,848-865
DOI : 10.1039/C8SC03381A, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Marvin N. Pohl, Eva Muchová, Robert Seidel, Hebatallah Ali, Štěpán Sršeň, Iain Wilkinson, Bernd Winter, Petr Slavíček
Ions have a profound effect on the geometrical structure of liquid water and an aqueous environment is known to change the electronic structure of ions.
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- Syntheses of defined sulfated oligohyaluronans reveal structural effects,
diversity and thermodynamics of GAG–protein binding
Abstract:Chem. Sci., 2019, 10,866-878
DOI : 10.1039/C8SC03649G, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Sebastian Köhling, Joanna Blaszkiewicz, Gloria Ruiz-Gómez, María Isabel Fernández-Bachiller, Katharina Lemmnitzer, Nydia Panitz, Annette G. Beck-Sickinger, Jürgen Schiller, M. Teresa Pisabarro, Jörg Rademann
High binding affinities of GAG toward extracellular regulatory proteins are governed by recognition diversity, sulfation pattern, length, and anomeric functionalization.
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- Ba4Bi2(Si8−xB4+xO29) (x = 0.09): a new acentric metal borosilicate as a
promising nonlinear optical material
Abstract:Chem. Sci., 2019, 10,837-842
DOI : 10.1039/C8SC04342F, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Ru-Ling Tang, Chun-Li Hu, Fei-Fei Mao, Jiang-He Feng, Jiang-Gao Mao
A novel acentric metal borosilicate, Ba4Bi2(Si8−xB4+xO29) (x = 0.09), exhibits the strongest NLO effects in borosilicates.
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- Conformer-specific [1,2]H-tunnelling in captodatively-stabilized
cyanohydroxycarbene (NC–̈–OH)
Abstract:Chem. Sci., 2019, 10,802-808
DOI : 10.1039/C8SC03720E, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.André K. Eckhardt, Frederik R. Erb, Peter R. Schreiner
Trans-Cyanohydroxycarbene undergoes conformer-specific [1,2]H-tunnelling to cyanoformaldehyde through the highest penetrated reaction barrier of 33.3 kcal mol−1 reported to date.
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- Mild complexation protocol for chiral CpxRh and Ir complexes suitable for
in situ catalysis
Abstract:Chem. Sci., 2019, 10,781-787
DOI : 10.1039/C8SC04385J, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.B. Audic, M. D. Wodrich, N. Cramer
Mild complexations of chiral cyclopentadienes with rhodium(I) and iridium(I) precursors enable user-friendly in situ complex formation for catalytic applications.
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- Enantioselective synthesis of gem-disubstituted N-Boc diazaheterocycles
via decarboxylative asymmetric allylic alkylation
Abstract:Chem. Sci., 2019, 10,788-792
DOI : 10.1039/C8SC03967D, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Alexander W. Sun, Stephan N. Hess, Brian M. Stoltz
An enantioselective synthesis of diverse N4-Boc-protected α,α-disubstituted piperazin-2-ones and tetrahydropyrimidin-2-ones using the palladiumcatalyzed decarboxylative allylic alkylation reaction has been achieved.
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- Crystallographic characterization of Lu2C2n (2n = 76–90):
cluster selection by cage size
Abstract:Chem. Sci., 2019, 10,829-836
DOI : 10.1039/C8SC03886D, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Wangqiang Shen, Lipiao Bao, Shuaifeng Hu, Le Yang, Peng Jin, Yunpeng Xie, Takeshi Akasaka, Xing Lu
Lu2C2n (2n = 76–90): the decisive size effect of the carbon cage on the configuration of the internal metallic cluster.
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- Bimetallic nickel–cobalt hydrides in H2 activation and catalytic
proton reduction
Abstract:Chem. Sci., 2019, 10,761-767
DOI : 10.1039/C8SC04346A, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Xiaoxiao Chu, Jihao Jin, Bangrong Ming, Maofu Pang, Xin Yu, Chen-Ho Tung, Wenguang Wang
The synergism of the redox properties of nickel and cobalt enables bimetallic NiCo complexes to process H2.
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- Photoredox-mediated remote C(sp3)–H heteroarylation of free alcohols
Abstract:Chem. Sci., 2019, 10,688-693
DOI : 10.1039/C8SC04134B, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Guo-Xing Li, Xiafei Hu, Gang He, Gong Chen
We report an efficient and economical method for remote δ C(sp3)–H heteroarylation of free aliphatic alcohols using a hypervalent iodine PFBI-OH oxidant under photoredox catalysis.
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- A synthetic approach to ‘click’ neoglycoprotein analogues of EPO
employing one-pot native chemical ligation and CuAAC chemistry
Abstract:Chem. Sci., 2019, 10,815-828
DOI : 10.1039/C8SC03409E, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.D. J. Lee, A. J. Cameron, T. H. Wright, P. W. R. Harris, M. A. Brimble
The batch-wise variability of commercial erythropoietin (EPO) preparations warrants development of more advanced synthetic methodologies. We have developed a diverse chemical toolkit to prepare ‘click’ neoglycoprotein variants of EPO.
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- Mechano-responsive circularly polarized luminescence of organic
solid-state chiral emitters
Abstract:Chem. Sci., 2019, 10,843-847
DOI : 10.1039/C8SC04026E, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Marine Louis, Ramarani Sethy, Jatish Kumar, Shouhei Katao, Régis Guillot, Takuya Nakashima, Clémence Allain, Tsuyoshi Kawai, Rémi Métivier
Mechano-CPL effect: chiral difluoro-boron β-diketonate complexes show concomitant changes of emission color as well as solid state chiroptical properties upon mechanical stimulation.
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- A copper-catalyzed double coupling enables a 3-step synthesis of the
quassinoid core architecture
Abstract:Chem. Sci., 2019, 10,768-772
DOI : 10.1039/C8SC03835J, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Matthew L. Condakes, Rachel Z. Rosen, Stephen J. Harwood, Thomas J. Maimone
A cross coupling/SN2′ tandem reaction is described to construct the polycyclic core architecture of the quassinoids, a fascinating class of degraded triterpenes with potent anticancer activity.
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- Relative orientation of the carbonyl groups determines the nature of
orbital interactions in carbonyl–carbonyl short contacts
Abstract:Chem. Sci., 2019, 10,909-917
DOI : 10.1039/C8SC04221G, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Biswajit Sahariah, Bani Kanta Sarma
The nature of orbital interactions in a carbonyl–carbonyl short contact is determined by the relative orientation of the two interacting carbonyl groups.
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- Strongly coloured thiocyanate frameworks with perovskite-analogue
structures
Abstract:Chem. Sci., 2019, 10,793-801
DOI : 10.1039/C8SC04082F, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Matthew J. Cliffe, Evan N. Keyzer, Matthew T. Dunstan, Shahab Ahmad, Michael F. L. De Volder, Felix Deschler, Andrew J. Morris, Clare P. Grey
We report the first examples of thiocyanate-based analogues of the cyanide Prussian blue compounds, MIII[Bi(SCN)6], M = Fe, Cr, Sc.
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- Growth of ZIF-8 on molecularly ordered 2-methylimidazole/single-walled
carbon nanotubes to form highly porous, electrically conductive composites
Abstract:Chem. Sci., 2019, 10,737-742
DOI : 10.1039/C8SC03987A, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.James E. Ellis, Zidao Zeng, Sean I. Hwang, Shaobo Li, Tian-Yi Luo, Seth C. Burkert, David L. White, Nathaniel L. Rosi, Jeremiah J. Gassensmith, Alexander Star
ZIF-8 crystals grow from SWCNT sidewalls to form a microporous, electrically conductive composite.
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- Click to enter: activation of oligo-arginine cell-penetrating peptides by
bioorthogonal tetrazine ligations
Abstract:Chem. Sci., 2019, 10,701-705
DOI : 10.1039/C8SC04394A, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Saskia A. Bode, Suzanne B. P. E. Timmermans, Selma Eising, Sander P. W. van Gemert, Kimberly M. Bonger, Dennis W. P. M. Löwik
The cellular uptake of a cell-penetrating peptide is controlled by reconstitution of two inactive halves using bioorthogonal tetrazine ligations and is applied to a fluorescently labelled protein.
The content of this RSS Feed (c) The Royal Society of Chemistry
- Influence of metal coordination and light irradiation on hierarchical
self-assembly processes
Abstract:Chem. Sci., 2019, 10,752-760
DOI : 10.1039/C8SC03875A, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Kalathil K. Kartha, Naveen Kumar Allampally, Antiope T. Politi, Deepak D. Prabhu, Hayato Ouchi, Rodrigo Q. Albuquerque, Shiki Yagai, Gustavo Fernández
We unravel the impact of metal coordination and light irradiation on hierarchical self-assembly processes by combined theoretical and experimental results.
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- Elucidating the molecular mechanisms of Criegee-amine chemistry in the gas
phase and aqueous surface environments
Abstract:Chem. Sci., 2019, 10,743-751
DOI : 10.1039/C8SC03514H, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Manoj Kumar, Joseph S. Francisco
Computational results suggest that the reactions of anti substituted Criegee intermediates with amine could lead to oligomers, which may play an important role in new particle formation and hydroxyl radical generation in the troposphere.
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- A double helix of opposite charges to form channels with unique CO2
selectivity and dynamics
Abstract:Chem. Sci., 2019, 10,730-736
DOI : 10.1039/C8SC04376K, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Guolong Xing, Irene Bassanetti, Silvia Bracco, Mattia Negroni, Charl Bezuidenhout, Teng Ben, Piero Sozzani, Angiolina Comotti
Electrostatic charges patterning along crystalline channels recognize CO2 with high selectivity and promote its fast screwing dynamics through the crystal at one million steps per second, strongly reminiscent of trans-membrane transport in biological channels.
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- Reductive diazotation of carbon nanotubes: an experimental and theoretical
selectivity study
Abstract:Chem. Sci., 2019, 10,706-717
DOI : 10.1039/C8SC03737J, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Milan Schirowski, Christoph Tyborski, Janina Maultzsch, Frank Hauke, Andreas Hirsch, Jakub Goclon
The reaction of negatively charged SWCNTs with diazonium salts was analyzed in a combined experimental and computational DFT study.
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- Rhodium(II)-catalyzed C–H aminations using N-mesyloxycarbamates:
reaction pathway and by-product formation
Abstract:Chem. Sci., 2019, 10,718-729
DOI : 10.1039/C8SC03153C, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Emna Azek, Maroua Khalifa, Johan Bartholoméüs, Matthias Ernzerhof, Hélène Lebel
DFT study to elucidate the mechanism of Rh-catalyzed C–H aminations with N-mesyloxycarbamates and the pathway by which by-products formed.
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- Single-molecule photoredox catalysis
Abstract:Chem. Sci., 2019, 10,681-687
DOI : 10.1039/C8SC03860K, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Josef Haimerl, Indrajit Ghosh, Burkhard König, Jan Vogelsang, John M. Lupton
Photocatalytic dehalogenation by a common dyestuff under aqueous conditions is driven by energy-additive absorption of two photons on the single-molecule level.
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- Hexakis(2,3,6-tri-O-methyl)-α-cyclodextrin–I5− complex in aqueous
I−/I3− thermocells and enhancement in the Seebeck coefficient
Abstract:Chem. Sci., 2019, 10,773-780
DOI : 10.1039/C8SC03821J, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Yimin Liang, Teppei Yamada, Hongyao Zhou, Nobuo Kimizuka
Supramolecular thermocell composed of I− (yellow balls), I3− (trio of red balls), I5− (five connected dark red balls) and Me18-α-CD (gray cone-shaped cylinder).
The content of this RSS Feed (c) The Royal Society of Chemistry
- Doping Strategies for Small Molecule Organic Hole-Transport Materials:
Impacts on Perovskite Solar Cell Performance and Stability
Abstract: Chem. Sci., 2019, Accepted Manuscript
DOI : 10.1039/C8SC05284K, Perspective Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Tracy H Schloemer, Jeffrey A Christians, Joseph M. Luther, Alan Sellinger
Hybrid organic/inorganic perovskite solar cells (PSCs) have dramatically changed the landscape of the solar research community over the past decade, but >25 year stability is likely required if they are...
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- The fate of bromine after temperature-induced dehydrogenation of
on-surface synthesized bisheptahelicene
Abstract: Chem. Sci., 2019, Accepted Manuscript
DOI : 10.1039/C8SC04720K, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Anaïs Mairena, Milos Baljozovic, Maciej Kawecki, Konstantin Grenader, Martin Wienke, Kevin Martin, Laetitia Bernard, Narcis Avarvari, Andreas Terfort, Karl-Heinz Ernst, Christian Wäckerlin
The on-surface synthesis of bisheptahelicene by Ullmann coupling of 9-bromoheptahelicene on Au(111) and its temperature-induced dehydrogenation is studied using temperature-programmed reaction spectroscopy and time-of-flight secondary ion mass spectrometry. Specific dehydrogenation...
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- Efficient synthesis of chiral 2,3-dihydro-benzo[b]thiophene 1,1-dioxides
via Rh-catalyzed hydrogenation
Abstract:Chem. Sci., 2019, Advance Article
DOI : 10.1039/C8SC05397A, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Gongyi Liu, Heng Zhang, Yi Huang, Zhengyu Han, Gang Liu, Yuanhua Liu, Xiu-Qin Dong, Xumu Zhang
Rh-Catalyzed asymmetric hydrogenation of substituted benzo[b]thiophene 1,1-dioxides was successfully developed. Both aromatic and alkyl substituted benzo[b]thiophene 1,1-dioxide substrates worked well with high yields and excellent enantioselectivities.
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- Lipid-independent control of endothelial and neuronal TRPC3 channels by
light
Abstract: Chem. Sci., 2019, Accepted Manuscript
DOI : 10.1039/C8SC05536J, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Oleksandra Tiapko, Niroj Shrestha, Sonja Lindinger, Gema Guedes de la Cruz, Annarita Graziani, Christiane Klec, Carmen Butorac, Wolfgang Graier, Helmut Kubista, Marc Freichel, Lutz Birnbaumer, Christoph Romanin, Toma N Glasnov, Klaus Groschner
Lipid-gated TRPC channels are highly expressed in cardiovascular- and neuronal tissues. Exerting precise pharmacological control over their activity in native cells is expected to serve as a basis for the...
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- Design of efficient thermally activated delayed fluorescence blue host for
high performance solution-processed hybrid white organic light emitting
diodes
Abstract: Chem. Sci., 2019, Accepted Manuscript
DOI : 10.1039/C8SC05456H, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Xinxin Ban, Feng Chen, Yan Liu, Jie Pan, Aiyun Zhu, Wei Jiang, Yueming Sun
Developing solution-processible blue thermally activated delayed fluorescence (TADF) emitter for hybrid white organic light emitting diodes (WOLEDs) is still challenge. In this work, two TADF blue emitters are designed and...
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- Programmable intracellular DNA biocomputing circuits for reliable cell
recognitions
Abstract: Chem. Sci., 2019, Accepted Manuscript
DOI : 10.1039/C8SC05217D, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Xue Gong, Jie Wei, Jing Liu, Ruomeng Li, Xiaoqing Liu, Fuan Wang
Dynamic nucleic acid-based biocircuits have spurred substantial research efforts for diagnosis or biomedical applications at the molecular level, nevertheless, it still remains a challenge to design programmable molecular circuit devices...
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- Tunable enzyme responses in amphiphilic nanoassemblies through alterations
in unimer-aggregate equilibrium
Abstract: Chem. Sci., 2019, Accepted Manuscript
DOI : 10.1039/C8SC04744H, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Jingjing Gao, Hui Wang, Jiaming Zhuang, Sankaran Thayumanavan
Developing design rules that offer tailorability in materials’ response to enzymes is of great importance, as such materials are of interest in a variety of biomedical applications including sensing, diagnostics...
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- A tandem dearomatization/rearomatization strategy: enantioselective
N-heterocyclic carbene-catalyzed α-arylation
Abstract:Chem. Sci., 2019, Advance Article
DOI : 10.1039/C8SC04601H, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Zijun Wu, Jian Wang
In this study, the first example of carbene-catalyzed tandem dearomatization/rearomatization reaction of azonaphthalenes with α-chloroaldehydes is described.
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- Formation of an ion-free crystalline carbon nitride and its reversible
intercalation with ionic species and molecular water
Abstract:Chem. Sci., 2019, Advance Article
DOI : 10.1039/C8SC05232H, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Theo M. Suter, Thomas S. Miller, Jeremy K. Cockcroft, Abil E. Aliev, Martin C. Wilding, Andrea Sella, Furio Corà, Christopher A. Howard, Paul F. McMillan
Crystalline layered carbon nitrides can be inter-converted by simple ion exchange process allowing their properties to be tuned.
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- [La(ηx-Bx)La]− (x = 7-9): A New Class of Inverse Sandwich
Complexes
Abstract: Chem. Sci., 2019, Accepted Manuscript
DOI : 10.1039/C8SC05443F, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Teng-Teng Chen, Wan-Lu Li, Jun Li, Lai-Sheng Wang
Despite the importance of bulk lanthanide borides, nanoclusters of lanthanide and boron have rarely been investigated. Here we show that lanthanide-boron binary clusters, La2Bx−, can form a new class of...
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- Correction: Enantioselective, convergent synthesis of the ineleganolide
core by a tandem annulation cascade
Abstract: Chem. Sci., 2019, Advance Article
DOI : 10.1039/C8SC90236D, Correction Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Robert A. Craig, Jennifer L. Roizen, Russell C. Smith, Amanda C. Jones, Scott C. Virgil, Brian M. Stoltz
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- Monomeric Cp3tAl(I): Synthesis, reactivity, and the concept of valence
isomerism
Abstract: Chem. Sci., 2019, Accepted Manuscript
DOI : 10.1039/C8SC05175E, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Holger Braunschweig, Thomas Kupfer, Alexander Hofmann, Tobias Tröster
With the isolation of Cp3tAl (1), the first monomeric Cp-based Al(I) species could be realized in pure form via a three-step reaction sequence (salt elimination/adduct formation/adduct cleavage) starting from readily...
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- Through-Space Charge Transfer Hexaarylbenzenes with Thermally Activated
Delayed Fluorescence and Aggregation-Induced Emission for Efficient
Solution-Processed OLEDs
Abstract: Chem. Sci., 2019, Accepted Manuscript
DOI : 10.1039/C8SC04991B, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Xingdong Wang, Shumeng Wang, Jianhong Lv, Shiyang Shao, Lixiang Wang, Xiabin Jing, Fosong Wang
Through-space electron interaction plays a critical role in determining the optical and charge transport properties of functional materials featuring π-stacked architectures. However, developing efficient organic luminescent materials with such interaction...
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- Free-standing Supercapacitors from Kraft Lignin Nanofibers with Remarkable
Volumetric Energy Density
Abstract: Chem. Sci., 2019, Accepted Manuscript
DOI : 10.1039/C8SC04936J, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Philipp Schlee, Servann Herou, Rhodri Jervis, Paul Shearing, Dan Brett, Darren Backer, Omid Hosseinaei, Per Tomani, Mangir Murshed, Yaomin Li, María José Mostazo-López, Diego Cazorla-Amorós, A Belen Jorge, Magdalena Titirici
We have discovered a very simple method to address the challenge associated with the low volumetric energy density of free-standing carbon fiber electrodes for supercapacitors by electrospinning Kraft lignin in...
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- Downsizing of Feature in Microphase-Separated Structures via
Intramolecular Crosslinking of Block Copolymers
Abstract: Chem. Sci., 2019, Accepted Manuscript
DOI : 10.1039/C8SC05016C, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Kodai Watanabe, Satoshi Katsuhara, Hiroaki Mamiya, Takuya Yamamoto, Kenji Tajima, Takuya Isono, Toshifumi Satoh
A novel strategy for downsizing the feature of microphase-separated structures was developed via intramolecular crosslinking reaction of block copolymers (BCPs) without changing the molecular weight. A series of BCPs consisting...
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- Selective recognition of choline phosphate by tripodal hexa-urea receptors
with dual binding sites: crystal and solution evidence
Abstract:Chem. Sci., 2019, Advance Article
DOI : 10.1039/C8SC04338H, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Wei Zuo, Chuandong Jia, Huizheng Zhang, Yanxia Zhao, Xiao-Juan Yang, Biao Wu
The tripodal hexa-urea receptors functionalized with aromatic terminal groups are able to selectively recognize choline phosphate with dual binding sites.
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- Intramolecular asymmetric reductive amination: synthesis of
enantioenriched dibenz[c,e]azepines
Abstract:Chem. Sci., 2019, Advance Article
DOI : 10.1039/C8SC04482A, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Tao Yang, Xiaochong Guo, Qin Yin, Xumu Zhang
An enantioselective synthesis of dibenz[c,e]azepines containing both central and axial chiralities through a one pot N-Boc deprotection/intramolecular asymmetric reductive amination sequence has been achieved with generally excellent enantiocontrol (up to 97% ee).
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- Enabling synthesis in fragment-based drug discovery by reactivity mapping:
photoredox-mediated cross-dehydrogenative heteroarylation of cyclic amines
Abstract:Chem. Sci., 2019, Advance Article
DOI : 10.1039/C8SC04789H, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Rachel Grainger, Tom D. Heightman, Steven V. Ley, Fabio Lima, Christopher N. Johnson
A nanogram-to-gram workflow has been established for the identification and development of synthetic transformations which are enabling in Fragment-Based Drug Discovery (FBDD). In this study, we disclose a method for the synthesis of privileged sp2–sp3 architectures via direct cross-dehydrogenative coupling of heterocycles.
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- Building blocks for recognition-encoded oligoesters that form H-bonded
duplexes
Abstract:Chem. Sci., 2019, Advance Article
DOI : 10.1039/C8SC04896G, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Filip T. Szczypiński, Christopher A. Hunter
A long-short base-pairing scheme hinders intramolecular folding and allows the use of flexible backbones in duplex-forming oligomers.
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- Aromatic C–H amination in hexafluoroisopropanol
Abstract:Chem. Sci., 2019, Advance Article
DOI : 10.1039/C8SC04966A, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Erica M. D'Amato, Jonas Börgel, Tobias Ritter
We report direct amination of electron-poor arenes and evaluate the crucial factors for the enhanced reactivity in hexafluoroisopropanol.
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- Dual-biomarker-triggered fluorescence probes for differentiating cancer
cells and revealing synergistic antioxidant effects under oxidative stress
Abstract: Chem. Sci., 2019, Accepted Manuscript
DOI : 10.1039/C8SC03781G, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Changyu Zhang, Qiangzhe Zhang, Kun Zhang, Luyuan Li, Michael D Pluth, Long Yi, Zhen Xi
Hydrogen sulfide (H2S) and human NAD(P)H:quinine oxidoreductase 1 (hNQO1) are potential cancer biomarkers and also vital participants in cellular redox homeostasis. Simultaneous detection of these two biomarkers would benefit the...
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- Reversible alkene binding and allylic C–H activation with an
aluminium(I) complex
Abstract:Chem. Sci., 2019, Advance Article
DOI : 10.1039/C8SC04865G, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Clare Bakewell, Andrew J. P. White, Mark R. Crimmin
The monomeric molecular aluminium(I) complex 1 [{(ArNCMe)2CH}Al] (Ar = 2,6-di-iso-propylphenyl) reacts with a series of terminal and strained alkenes including ethylene, propylene, allylbenzene and norbornene to form alkene bound products.
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- Monitoring metal–amyloid-β complexation by a FRET-based probe: design,
detection, and inhibitor screening
Abstract:Chem. Sci., 2019, Advance Article
DOI : 10.1039/C8SC04943B, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Hyuck Jin Lee, Young Geun Lee, Juhye Kang, Seung Hyun Yang, Ju Hwan Kim, Amar B. T. Ghisaidoobe, Hyo Jin Kang, Sang-Rae Lee, Mi Hee Lim, Sang J. Chung
A FRET-based method was developed for monitoring metal–amyloid-β complexation and identifying inhibitors against such interaction.
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- Faceted Polymersomes: A Sphere-to-Polyhedron Shape Transformation
Abstract: Chem. Sci., 2019, Accepted Manuscript
DOI : 10.1039/C8SC04206C, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Chin Ken Ken Wong, Adam David Martin, Matthias Floetenmeyer, Robert G Parton, Martina Heide Stenzel, Pall Thordarson
The creation of “soft” deformable hollow polymeric nanoparticles with complex non-spherical shapes via block copolymer self-assembly remains a challenge. In this work, we show that a perylene-bearing block copolymer can...
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- Ubiquitin binds the Amyloid β peptide and interferes with its
clearance pathways
Abstract: Chem. Sci., 2019, Accepted Manuscript
DOI : 10.1039/C8SC03394C, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Francesco Bellia, Valeria Lanza, Sara García-Viñuales, Ikhlas Mohamed Mohamud Ahmed, Adriana Pietropaolo, Claudio Iacobucci, Gaetano Malgieri, Gianluca D'Abrosca, Roberto Fattorusso, Vincenzo Giuseppe Nicoletti, Diego Sbardella, Grazia Raffaella Tundo, Massimo Coletta, Luciano Pirone, Emilia Pedone, Damiano Calcagno, Giuseppe Grasso, Danilo Milardi
Several lines of evidence point to a compromised proteostasis associated to a reduction of the Ubiquitin Proteasome System (UPS) activity in patients affected by Alzheimer’s Disease (AD) and suggest that...
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- N1-methyladenosine detection with CRISPR-Cas13a/C2c2
Abstract: Chem. Sci., 2019, Accepted Manuscript
DOI : 10.1039/C8SC03408G, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Yi Chen, Shixi Yang, Shuang Peng, Wei Li, Fan Wu, Qian Yao, Fang Wang, Xiaocheng Weng, Xiang Zhou
Recent studies suggested the widespread presence of N1-methyladenosine (m1A) plays a very important role in environmental stress, ribosome biogenesis and antibiotic resistance. The RNA-guided, RNA-targeting CRISPR Cas13a exhibits a “collateral...
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- Photolysis of cell-permeant caged inositol pyrophosphates controls
oscillations of cytosolic calcium in a β-cell line
Abstract: Chem. Sci., 2019, Accepted Manuscript
DOI : 10.1039/C8SC03479F, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Sebastian Hauke, Amit Dutta, Verena Eisenbeis, Dominik Bezold, Tamara Bittner, Christopher Wittwer, Divyesh Thakor, Igor Pavlovic, Carsten Schultz, Henning Jacob Jessen
Among many cellular functions, inositol pyrophosphates (PP-InsPs) are metabolic messengers involved in the regulation of glucose uptake, insulin sensitivity, and weight gain. However, their mechanisms of action are still poorly...
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- UV-irradiation of self-assembled triphenylamines affords persistent and
regenerable radicals
Abstract: Chem. Sci., 2019, Accepted Manuscript
DOI : 10.1039/C8SC04607G, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Ammon J. Sindt, Baillie A. DeHaven, David F McEachern, Madushanka M. Dissanayake, Mark D. Smith, Aaron K. Vannucci, Linda S Shimizu
UV-irradiation of assembled urea-tethered triphenylamine dimers results in the formation of persistent radicals, whereas radicals generated in solution are reactive and quickly degrade. In the solid-state, high quantities of radicals...
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- Surface Radio-Mineralisation Mediates Chelate-free Radiolabelling of Iron
Oxide Nanoparticles
Abstract: Chem. Sci., 2019, Accepted Manuscript
DOI : 10.1039/C8SC04895A, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.P. Stephen Patrick, Lara Bogart, Thomas J Macdonald, Paul Southern, Michael Powell, Mawy Zaw-Thin, Nico H. Voelcker, Ivan P Parkin, Quentin Andrew Pankhurst, Mark F Lythgoe, Tammy Kalber, Joseph C Bear
We introduce the concept of surface radio-mineralisation (SRM) to describe the chelate-free radiolabelling of iron-oxide and ferrite nanoparticles. We demonstrate the effectiveness of SRM with both 111In and 89Zr for...
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- Selective C−C Bond Formation from Rhodium-Catalyzed C−H Activation
Reaction of 2-Arylpyridines with 3-Ary-2H-azirines
Abstract: Chem. Sci., 2019, Accepted Manuscript
DOI : 10.1039/C8SC05142A, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Yonghyeon Baek, Jinwoo Kim, Hyunseok Kim, Seung Jin Jung, Ho Ryu, Suyeon Kim, Jeong-Yu Son, Kyusik Um, Sang Hoon Han, Hyung Jin Seo, Juyoung Heo, Kooyeon Lee, Mu-Hyun Baik, Phil Ho Lee
A novel method for the synthesis of acylmethyl-substituted 2-arylpyridine derivatives using 3-aryl-2H-azirines was developed by exploring a prototype reaction using DFT-calculations and carrying out targeted experiments guided by the calculated...
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- Low overpotential water oxidation at neutral pH catalyzed by a copper(II)
porphyrin
Abstract: Chem. Sci., 2019, Accepted Manuscript
DOI : 10.1039/C8SC04529A, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Yanju Liu, Yongzhen Han, Zongyao Zhang, Wei Zhang, Wenzhen Lai, Yong Wang, Rui Cao
Low overpotential water oxidation under mild conditions is required for new energy conversion technologies with potential application prospects. Extensive studies on molecular catalysis have been performed to gain fundamental knowledge...
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- Imidazole-modified G-quadruplex DNA as Metal-triggered Peroxidase
Abstract: Chem. Sci., 2019, Accepted Manuscript
DOI : 10.1039/C8SC05020A, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Philip M Punt, Guido H. Clever
Four imidazoles, serving as metalloprotein-inspired ligands for complexing a range of transition metal cations, were incorporated into tetramolecular G-quadruplex DNA structures. Modified quadruplexes were found to complex Cu(II), Ni(II), Zn(II)...
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- Structural insights reveal a recognition feature for tailoring hydrocarbon
stapled-peptides against the eukaryotic translation initiation factor 4E
protein
Abstract: Chem. Sci., 2019, Accepted Manuscript
DOI : 10.1039/C8SC03759K, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.dilraj lama, Anne-Marie Liberatore, Yuri Frosi, Jessica Nakhle, Natia Tsomaia, Tarig Bashir, David Lane, Christopher Brown, Chandra Verma, Serge Auvin
Stapled-peptides have emerged as an exciting class of molecules which can modulate protein-protein interactions. We have used a structure-guided approach to rationally develop a set of hydrocarbon stapled-peptides with high...
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- Highly Enantioselective "Inherently Chiral" Electroactive Materials Based
on the 2,2'-Biindole Atropisomeric Scaffold
Abstract: Chem. Sci., 2019, Accepted Manuscript
DOI : 10.1039/C8SC04862B, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Serena Arnaboldi, tiziana Benincori, Andrea Penoni, Luca Vaghi, Roberto Cirilli, Sergio Abbate, Giovanna Longhi, Giuseppe Mazzeo, Sara Grecchi, Monica Panigati, Patrizia Romana Mussini
Chiral oligothiophene monomers with C2 symmetry, based on 3,3'-bithiophene atropisomeric cores with high racemization barriers, have been recently shown to provide excellent chiral starting materials with high electroactivity for the...
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- A step-by-step reaction powered mechanical motion triggered by a chemical
fuel pulse
Abstract: Chem. Sci., 2019, Accepted Manuscript
DOI : 10.1039/C8SC05469J, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Qiang Shi, Chuan-Feng Chen
Nature molecular machines perform important tasks in organisms under the reasonable energy supply strategy: a series of step-by-step biochemical reactions after the intake of fuel such as glucose. As the...
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- In-Depth Structural Analysis of Glycans in the Gas Phase
Abstract: Chem. Sci., 2019, Accepted Manuscript
DOI : 10.1039/C8SC05426F, Minireview Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Eike Mucha, Alexandra Stuckmann, Mateusz Marianski, Weston B. Struwe, Gerard Meijer, Kevin Pagel
Although there have been substantial improvements in glycan analysis over the past decade, the lack of both high-resolution and high-throughput methods hampers progress in glycomics. This perspective article highlights the...
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- Macrocyclisation of Small Peptides Enabled by Oxetane Incorporation
Abstract: Chem. Sci., 2019, Accepted Manuscript
DOI : 10.1039/C8SC05474F, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Stefan Roesner, George Saunders, Ina Wilkening, Eleanor Jayawant, Joanna Geden, Paul Kerby, Ann Dixon, Rebecca Notman, Mike Shipman
Cyclic peptides are an important source of new drugs but are challenging to produce synthetically. We show that head-to-tail peptide macrocyclisations are greatly improved, as measured by isolated yields, reaction...
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- A Hypervalent and Cubically Coordinated Molecular Phase of IF8 Predicted
at High Pressure
Abstract: Chem. Sci., 2019, Accepted Manuscript
DOI : 10.1039/C8SC04635B, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Dongbao Luo, Jian Lv, Feng Peng, Yanchao Wang, Guochun Yang, Martin Rahm, Yanming Ma
Up to now, the maximum coordination number of iodine is seven in neutral iodine heptafluoride (IF7) and eight in anionic octafluoride (IF8-). Here, we explore pressure as a method for...
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- Solution and On-Surface Synthesis of Structurally Defined Graphene
Nanoribbons as a New Family of Semiconductors
Abstract: Chem. Sci., 2019, Accepted Manuscript
DOI : 10.1039/C8SC03780A, Minireview Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Akimitsu Narita, Zongping Chen, Qiang Chen, K. Muellen
Graphene nanoribbons (GNRs) are quasi-one-dimensional subunits of graphene and have open bandgaps in contrast to the zero-bandgap graphene. The high potential of GNRs as a new family of carbon-based semiconductors,...
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- Halogenoborane mediated allene cyclooligomerization
Abstract: Chem. Sci., 2019, Accepted Manuscript
DOI : 10.1039/C8SC04790A, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Gerhard Erker, Xin Tao, Christian Wölke, Constantin Gabriel Daniliuc, Gerald Kehr
The halogenoboranes XB(C6F5)2 (X: Cl, Br) react with allene to give a mixture of the cyclotrimer 1,3,5-trimethylenecyclohexane (1) and the related halogenoborylated cyclotetramerization products 4a and 4b. Alkyl-substituted allenes were...
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- Electrocatalytic hydrogen evolution with gallium hydride and
ligand-centered reduction
Abstract: Chem. Sci., 2019, Accepted Manuscript
DOI : 10.1039/C8SC05247F, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Ni Wang, Haitao Lei, Zongyao Zhang, Jianfeng Li, Wei Zhang, Rui Cao
GaIII chloride tetrakis(pentafluorophenyl)porphyrin (1) was synthesized and shown to be a highly active and stable post-transition metal-based electrocatalyst for the hydrogen evolution reaction (HER). Electrochemical and spectroscopic studies indicate that...
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- Lysosome targeted photoactivation reveals local sphingosine metabolism
signature
Abstract: Chem. Sci., 2019, Accepted Manuscript
DOI : 10.1039/C8SC03614D, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Suihan Feng, Takeshi Harayama, Dalu Chang, J. Thomas Hannich, Nicolas Winssinger, Howard Riezman
Lipids are essential components of eukaryotic cell membranes and play crucial roles in cellular signaling and metabolism. While increasing evidence shows that the activities of lipids are dependent upon subcellular...
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- Picosecond Multi-Hole Transfer and Microsecond Charge-Separated States at
the Perovskite Nanocrystal/Tetracene Interface
Abstract: Chem. Sci., 2019, Accepted Manuscript
DOI : 10.1039/C8SC04408B, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Xiao Luo, Guijie Liang, Junhui Wang, Xue Liu, Kaifeng Wu
Hole transfer (HT) is often kinetically sluggish compared to electron transfer (ET), which increases recombination losses and thus limits the efficiency of many energy conversion processes such as light-emitting diodes,...
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- How to control selectivity in alkane oxidation'
Abstract: Chem. Sci., 2019, Accepted Manuscript
DOI : 10.1039/C8SC04641G, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Xuan Li, Detre Teschner, Verena Streibel, Thomas Lunkenbein, Liudmyla Masliuk, Teng Fu, Yuanqing Wang, Travis Jones, Friedrich Seitz, Frank Girgsdies, Frank Rosowski, R Schlogl, Annette Trunschke
The well-defined particle morphology of crystalline MnWO4 catalysts investigated in the present study facilitates insight into the origin of selectivity limitations in alkane oxidation. Hydrothermal synthesis at variable pH values...
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