|
Chemical Science
Journal Prestige (SJR): 4.508  Citation Impact (citeScore): 9 Number of Followers: 36  Open Access journalISSN (Print) 1478-6524 - ISSN (Online) 2041-6520 Published by RSC  [49 journals]
|
- Predicting chemical reactivity of organic materials using machine-learning
approach
Abstract: Chem. Sci., 2020, Accepted Manuscript
DOI : 10.1039/D0SC01328E, Edge Article
Open Access 
This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Byungju Lee, Jaekyun Yoo, Kisuk Kang
The stability and/or compatibility between chemical components are one of the essential parameters that need to be considered in the selection of functional materials in the system configuration. In configuring...
The content of this RSS Feed (c) The Royal Society of Chemistry
- New Directions of Activity-Based Sensing for in vivo NIR Imaging
Abstract: Chem. Sci., 2020, Accepted Manuscript
DOI : 10.1039/D0SC03096A, Perspective Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Amanda K East, Melissa Y Lucero, Jefferson Chan
In vivo imaging is a powerful approach to study biological processes. Beyond cellular methods, in vivo studies allow for biological stimuli (small molecules or proteins) to be studied in their...
The content of this RSS Feed (c) The Royal Society of Chemistry
- Power to the Protein: Enhancing and Combining Activities using the Spy
Toolbox
Abstract: Chem. Sci., 2020, Accepted Manuscript
DOI : 10.1039/D0SC01878C, Minireview Open Access 
This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Anthony Howard Keeble, Mark Howarth
Proteins span an extraordinary range of shapes, sizes and functionalities. Therefore generic approaches are needed to overcome this diversity and stream-line protein analysis or application. Here we review SpyTag technology,...
The content of this RSS Feed (c) The Royal Society of Chemistry
- Core remodeling leads to long wavelength fluoro-coumarins
Abstract:Chem. Sci., 2020, Advance Article
DOI : 10.1039/D0SC02566F, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Siddharth S. Matikonda, Joseph Ivanic, Miguel Gomez, Gabrielle Hammersley, Martin J. Schnermann
Fluoro-Coumarins are a novel class of far-red and near-infrared solvent sensitive dyes of exceptionally low molecular weight.
To cite this article before page numbers are assigned, use the
DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry
- Helix-constructed polar rare-earth iodate fluoride as a laser nonlinear
optical multifunctional material
Abstract:Chem. Sci., 2020, Advance Article
DOI : 10.1039/D0SC02789H, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Guang Peng, Yi Yang, Tao Yan, Dan Zhao, Bingxuan Li, Ge Zhang, Zheshuai Lin, Ning Ye
The first trivalent rare-earth iodate fluoride nonlinear optical (NLO) crystal, Y(IO3)2F (YIF), was successfully designed and synthesized, featuring polarization-favorable helical chains constructed from trans-YO6F2 polyhedra and IO3 groups.
To cite this article before page numbers are assigned, use the
DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry
- Correction: Water-induced formation of an alkali-ion dimer in cryptomelane
nanorods
Abstract: Chem. Sci., 2020, Advance Article
DOI : 10.1039/D0SC90126A, Correction Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Shaobo Cheng, Vidushi Sharma, Altug S. Poyraz, Lijun Wu, Xing Li, Amy C. Marschilok, Esther S. Takeuchi, Kenneth J. Takeuchi, Marivi Fernández-Serra, Yimei Zhu
To cite this article before page numbers are assigned, use the
DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry
- Unusually high α-proton acidity of prolyl residues in cyclic peptides
Abstract: Chem. Sci., 2020, Accepted Manuscript
DOI : 10.1039/D0SC02508A, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Oliver R Maguire, Bethany Taylor, Eleanor M Higgins, Matthew Rees, Steven L Cobb, N. S. Simpkins, Christopher J Hayes, AnnMarie Christine O'Donoghue
The acidity of the α-proton in peptides has an essential role in numerous biochemical reactions and underpins their stereochemical integrity which is critical to their biological function. We report here...
The content of this RSS Feed (c) The Royal Society of Chemistry
- Large Transition State Stabilization from a Weak Hydrogen Bond
Abstract: Chem. Sci., 2020, Accepted Manuscript
DOI : 10.1039/D0SC02806A, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Erik C Vik, Ping Li, Josef M Maier, Daniel O. Madukwe, Vitaly A. Rassolov, Perry J. Pellechia, Eric Masson, Ken D Shimizu
A series of molecular rotors was designed to study and measure the rate accelerating effects of an intramolecular hydrogen bond. The rotors form a weak neutral O-H•••O=C hydrogen bond in...
The content of this RSS Feed (c) The Royal Society of Chemistry
- Exohedral functionalization vs. core expansion of siliconoids with Group 9
metals: catalytic activity in alkene isomerization
Abstract: Chem. Sci., 2020, Accepted Manuscript
DOI : 10.1039/D0SC02861D, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Nadine Elisabeth Poitiers, Luisa Giarrana, Volker Huch, Michael Zimmer, David Scheschkewitz
Taking advantage of a pending tetrylene side-arms, stable unsaturated Si6 silicon clusters (siliconoids) with the benzpolarene motif (the energetic counterpart of benzene in silicon chemistry) are succesfully employed as ligands...
The content of this RSS Feed (c) The Royal Society of Chemistry
- Molecular crowding effects on biochemical properties of amyloid β-heme,
Aβ-Cu and Aβ-heme-Cu complexes
Abstract: Chem. Sci., 2020, Accepted Manuscript
DOI : 10.1039/D0SC01020K, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Meng Li, Zhenqi Liu, Jinsong Ren, Xiaogang Qu
Heme as a cofactor has been proposed to bind with β-amyloid peptide (Aβ) and the formed Aβ-heme complex exhibits enhanced peroxidase-like activity. So far, in vitro studies on the interactions...
The content of this RSS Feed (c) The Royal Society of Chemistry
- Insights into the behavior of nonanoic acid and its conjugate base at the
air/water interface through a combined experimental and theoretical
approach
Abstract:Chem. Sci., 2020, Advance Article
DOI : 10.1039/D0SC02354J, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Man Luo, Nicholas A. Wauer, Kyle J. Angle, Abigail C. Dommer, Meishi Song, Christopher M. Nowak, Rommie E. Amaro, Vicki H. Grassian
The surface partitioning of a medium chain fatty acid and its conjugate base has been investigated through a combined experimental and theoretical approach of the multi-equilibria involved in the bulk phase and at the air/water interface.
To cite this article before page numbers are assigned, use the
DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry
- Ring-Opening Carbonyl-Olefin Metathesis of Norbornenes
Abstract: Chem. Sci., 2020, Accepted Manuscript
DOI : 10.1039/D0SC02243H, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Janis Jermaks, Phong Quach, Zara M Seibel, Julien Pomarole, Tristan Lambert
A computational and experimental study of the hydrazine-catalyzed ring-opening carbonyl-olefinmetathesis of norbornenes is described. Detailed theoretical investigation of the energetic landscapefor the full reaction pathway with six different hydrazines revealed...
The content of this RSS Feed (c) The Royal Society of Chemistry
- Photophysical implications of ring fusion, linker length, and twisting
angle in a series of perylenediimide–thienoacene dimers
Abstract:Chem. Sci., 2020, Advance Article
DOI : 10.1039/D0SC02862B, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Ariel A. Leonard, Martín A. Mosquera, Leighton O. Jones, Zhengxu Cai, Thomas J. Fauvell, Matthew S. Kirschner, David J. Gosztola, George C. Schatz, Richard D. Schaller, Luping Yu, Lin X. Chen
Ring fusion and conjugated bridge length dependent exciton dynamics and electronic coupling in a series of perylenediimide dimers with acceptor–donor–acceptor arrangement are investigated by ultrafast optical spectroscopy and TDDFT calculations.
To cite this article before page numbers are assigned, use the
DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry
- Nitrogen-doped semiconducting oxides. Implications on photochemical,
photocatalytic and electronic properties derived from EPR spectroscopy
Abstract:Chem. Sci., 2020, Advance Article
DOI : 10.1039/D0SC02876B, Perspective Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Mario Chiesa, Stefano Livraghi, Maria Cristina Paganini, Enrico Salvadori, Elio Giamello
Engineered nitrogen defects in semiconducting oxides imparts appealing photophysical and photochemical properties to the materials which can be selectively addressed through EPR spectroscopy.
To cite this article before page numbers are assigned, use the
DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry
- Deoxygenative α-Alkylation and α-Arylation of 1,2-Dicarbonyls
Abstract: Chem. Sci., 2020, Accepted Manuscript
DOI : 10.1039/D0SC03118F, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Shengfei Jin, Hang T. Dang, Graham C. Haug, Viet D Nguyen, Hadi Arman, Oleg V. Larionov
Construction of C‒C bonds at the α-carbon is a challenging but synthetically indispensable approach to α-branched carbonyl motifs that are widely represented among drugs, natural products, and synthetic intermediates. Here,...
The content of this RSS Feed (c) The Royal Society of Chemistry
- GaN nanowire as a reusable photoredox catalyst for radical coupling of
carbonyl under blacklight-irradiation
Abstract: Chem. Sci., 2020, Accepted Manuscript
DOI : 10.1039/D0SC02718A, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Mingxin Liu, Lida Tan, Roksana Tonny Rashid, Yunen Cen, Shaobo Cheng, Gianluigi Botton, Zetian Mi, Chao-Jun Li
Employing photo-energy to drive the desired chemical transformation has been a long pursuing subject. The development of homogeneous photoredox catalysts in radical coupling reactions has been truly phenomenal, however with...
The content of this RSS Feed (c) The Royal Society of Chemistry
- Celebrating 10 years of Chemical Science
Abstract:Chem. Sci., 2020, 11,6351-6351
DOI : 10.1039/D0SC90127J, Editorial Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Welcome to the first of our special anniversary issues planned for this year, marking 10 years since Chemical Science published its first issue, back in July 2010.
The content of this RSS Feed (c) The Royal Society of Chemistry
- Comprehending the quadruple bonding conundrum in C2 from excited state
potential energy curves
Abstract:Chem. Sci., 2020, Advance Article
DOI : 10.1039/D0SC02336A, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Ishita Bhattacharjee, Debashree Ghosh, Ankan Paul
The question of quadruple bonding in C2 has emerged as a hot button issue, with opinions sharply divided between the practitioners of Valence Bond (VB) and Molecular Orbital (MO) theory.
To cite this article before page numbers are assigned, use the
DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry
- Conformational design concepts for anions in ionic liquids
Abstract:Chem. Sci., 2020, 11,6405-6422
DOI : 10.1039/D0SC01379J, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Frederik Philippi, David Pugh, Daniel Rauber, Tom Welton, Patricia A. Hunt
Interchangeable functional groups for imide ions are investigated computationally, new ILs with low/high viscosity are designed a priori and experimentally characterised.
The content of this RSS Feed (c) The Royal Society of Chemistry
- Luminescent tungsten(VI) complexes as photocatalysts for light-driven
C–C and C–B bond formation reactions
Abstract:Chem. Sci., 2020, 11,6370-6382
DOI : 10.1039/D0SC01340D, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Daohong Yu, Wai-Pong To, Glenna So Ming Tong, Liang-Liang Wu, Kaai-Tung Chan, Lili Du, David Lee Phillips, Yungen Liu, Chi-Ming Che
A luminescent tungsten(VI) complex catalyses a broad spectrum of light-driven organic transformation reactions with high product yields and good functional group tolerance.
The content of this RSS Feed (c) The Royal Society of Chemistry
- Continuous and scalable synthesis of a porous organic cage by twin screw
extrusion (TSE)
Abstract:Chem. Sci., 2020, 11,6582-6589
DOI : 10.1039/D0SC01858A, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Benjamin D. Egleston, Michael C. Brand, Francesca Greenwell, Michael E. Briggs, Stuart L. James, Andrew I. Cooper, Deborah E. Crawford, Rebecca L. Greenaway
Twin screw extrusion (TSE) is demonstrated as an alternative synthetic method for preparing a prolific porous organic cage.
The content of this RSS Feed (c) The Royal Society of Chemistry
- Chemical synthesis of human syndecan-4 glycopeptide bearing O-,
N-sulfation and multiple aspartic acids for probing impacts of the glycan
chain and the core peptide on biological functions
Abstract:Chem. Sci., 2020, 11,6393-6404
DOI : 10.1039/D0SC01140A, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Weizhun Yang, Yigitcan Eken, Jicheng Zhang, Logan Emerson Cole, Sherif Ramadan, Yongmei Xu, Zeren Zhang, Jian Liu, Angela K. Wilson, Xuefei Huang
Attaching heparan sulfate glycan on a peptide backbone can modulate biological functions of the glycan.
The content of this RSS Feed (c) The Royal Society of Chemistry
- Triblock polyester thermoplastic elastomers with semi-aromatic polymer end
blocks by ring-opening copolymerization
Abstract:Chem. Sci., 2020, 11,6567-6581
DOI : 10.1039/D0SC00463D, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Georgina L. Gregory, Gregory S. Sulley, Leticia Peña Carrodeguas, Thomas T. D. Chen, Alba Santmarti, Nicholas J. Terrill, Koon-Yang Lee, Charlotte K. Williams
A new series of block polyester thermoplastic elastomers are prepared by a one-pot procedure; they show properties competitive or better than conventional materials and can be fully degraded after use.
The content of this RSS Feed (c) The Royal Society of Chemistry
- Ultrafast amidation of esters using lithium amides under aerobic ambient
temperature conditions in sustainable solvents
Abstract:Chem. Sci., 2020, 11,6500-6509
DOI : 10.1039/D0SC01349H, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Michael Fairley, Leonie J. Bole, Florian F. Mulks, Laura Main, Alan R. Kennedy, Charles T. O'Hara, Joaquín García-Alvarez, Eva Hevia
Using 2-methyl THF as solvent enables efficient and ultrafast amidation of esters by lithium amides at room temperature in air, edging closer towards reaching air- and moisture-compatible polar organometallic chemistry.
The content of this RSS Feed (c) The Royal Society of Chemistry
- pH-Responsive Au(I)-disulfide nanoparticles with tunable
aggregation-induced emission for monitoring intragastric acidity
Abstract:Chem. Sci., 2020, 11,6472-6478
DOI : 10.1039/D0SC01843K, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Jianxing Wang, Jie Li, Ying Li, Zhijun Zhang, Lei Wang, Dong Wang, Lei Su, Xueji Zhang, Ben Zhong Tang
The water-stable and pH-responsive Au(I)-disulfide NPs serve as a luminescent probe for monitoring intragastric acidity in an acid-suppressed therapy.
The content of this RSS Feed (c) The Royal Society of Chemistry
- Cationic indium catalysts for ring opening polymerization: tuning
reactivity with hemilabile ligands
Abstract:Chem. Sci., 2020, 11,6485-6491
DOI : 10.1039/D0SC01291B, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Chatura Goonesinghe, Hootan Roshandel, Carlos Diaz, Hyuk-Joon Jung, Kudzanai Nyamayaro, Maria Ezhova, Parisa Mehrkhodavandi
This is an in-depth study into the role hemilabile ligands play in tuning stability and reactivity in cationic indium complexes.
The content of this RSS Feed (c) The Royal Society of Chemistry
- Tuning reactivity layer-by-layer: formic acid activation on Ag/Pd(111)
Abstract:Chem. Sci., 2020, 11,6492-6499
DOI : 10.1039/D0SC01461C, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Mustafa Karatok, Kaining Duanmu, Christopher R. O'Connor, Jorge Anibal Boscoboinik, Philippe Sautet, Robert J. Madix, Cynthia M. Friend
Modified electronic structure of Ag monolayer on Pd(111) enhances reactivity of Ag towards formic acid.
The content of this RSS Feed (c) The Royal Society of Chemistry
- In situ Raman study of the photoinduced behavior of dye molecules on
TiO2(hkl) single crystal surfaces
Abstract:Chem. Sci., 2020, 11,6431-6435
DOI : 10.1039/D0SC00588F, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Sheng-Pei Zhang, Jia-Sheng Lin, Rong-Kun Lin, Petar M. Radjenovic, Wei-Min Yang, Juan Xu, Jin-Chao Dong, Zhi-Lin Yang, Wei Hang, Zhong-Qun Tian, Jian-Feng Li
In dye-sensitized solar cells (DSSCs), the TiO2/dye interface significantly affects photovoltaic performance.
The content of this RSS Feed (c) The Royal Society of Chemistry
- A visible-light Paternò–Büchi dearomatisation process towards the
construction of oxeto-indolinic polycycles
Abstract:Chem. Sci., 2020, 11,6532-6538
DOI : 10.1039/D0SC01569E, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Javier Mateos, Alberto Vega-Peñaloza, Pietro Franceschi, Francesco Rigodanza, Philip Andreetta, Xavier Companyó, Giorgio Pelosi, Marcella Bonchio, Luca Dell’Amico
A scalable visible-light [2 + 2]-heterocycloaddition process allows the dearomatisation of indoles to complex biorelevant polycycles.
The content of this RSS Feed (c) The Royal Society of Chemistry
- Oxidation promoted self-assembly of π-conjugated polymers
Abstract:Chem. Sci., 2020, 11,6383-6392
DOI : 10.1039/D0SC00806K, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Garion E. J. Hicks, Charles N. Jarrett-Wilkins, Jenny R. Panchuk, Joseph G. Manion, Dwight S. Seferos
Conjugated block copolymers, where each block contains a unique electroactive group, allows selective block-oxidation in solution, which promotes reversible, redox-controlled self-assembly.
The content of this RSS Feed (c) The Royal Society of Chemistry
- Microfluidic systems for rapid antibiotic susceptibility tests (ASTs) at
the single-cell level
Abstract:Chem. Sci., 2020, 11,6352-6361
DOI : 10.1039/D0SC01353F, Minireview Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Kaixiang Zhang, Shangshang Qin, Sixuan Wu, Yan Liang, Jinghong Li
Recent developments of microfluidics-based antibiotic susceptibility tests (ASTs) at the single-cell or single-molecule level are summarized for guiding antibiotic treatment.
The content of this RSS Feed (c) The Royal Society of Chemistry
- Efficient photocatalytic hydrogen evolution on single-crystalline metal
selenide particles with suitable cocatalysts
Abstract:Chem. Sci., 2020, 11,6436-6441
DOI : 10.1039/D0SC01167C, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Shanshan Chen, Junie Jhon M. Vequizo, Takashi Hisatomi, Mamiko Nakabayashi, Lihua Lin, Zheng Wang, Akira Yamakata, Naoya Shibata, Tsuyoshi Takata, Taro Yamada, Kazunari Domen
Coloading of a Ni–Ru composite cocatalyst on a 700 nm-class single-crystalline particulate selenide photocatalyst improves its hydrogen evolution activity.
The content of this RSS Feed (c) The Royal Society of Chemistry
- Kinetics of cooperative CO2 adsorption in diamine-appended variants of the
metal–organic framework Mg2(dobpdc)
Abstract:Chem. Sci., 2020, 11,6457-6471
DOI : 10.1039/D0SC01087A, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Jeffrey D. Martell, Phillip J. Milner, Rebecca L. Siegelman, Jeffrey R. Long
An in-depth investigation of the CO2 adsorption kinetics of a promising class of cooperative carbon capture materials offers new insight into their structure-performance properties.
The content of this RSS Feed (c) The Royal Society of Chemistry
- A regioselectively 1,1′,3,3′-tetrazincated ferrocene complex
displaying core and peripheral reactivity
Abstract:Chem. Sci., 2020, 11,6510-6520
DOI : 10.1039/D0SC01612H, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Gordon W. Honeyman, David R. Armstrong, William Clegg, Eva Hevia, Alan R. Kennedy, Ross McLellan, Samantha A. Orr, John A. Parkinson, Donna L. Ramsay, Stuart D. Robertson, Stephen Towie, Robert E. Mulvey
A tetrazincated ferrocene complex displays divergent basicity towards aromatic substrates through either its core or peripheral ligands.
The content of this RSS Feed (c) The Royal Society of Chemistry
- Halogen-directed chemical sialylation: pseudo-stereodivergent access to
marine ganglioside epitopes
Abstract:Chem. Sci., 2020, 11,6527-6531
DOI : 10.1039/D0SC01219J, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Taiki Hayashi, Alexander Axer, Gerald Kehr, Klaus Bergander, Ryan Gilmour
Sialic acids are conspicuous structural components of the complex gangliosides that regulate cellular processes.
The content of this RSS Feed (c) The Royal Society of Chemistry
- Late-stage C(sp2)–H and C(sp3)–H glycosylation of C-aryl/alkyl
glycopeptides: mechanistic insights and fluorescence labeling
Abstract:Chem. Sci., 2020, 11,6521-6526
DOI : 10.1039/D0SC01260B, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Jun Wu, Nikolaos Kaplaneris, Shaofei Ni, Felix Kaltenhäuser, Lutz Ackermann
C–H glycosylations of complex amino acids and peptides were accomplished through the assistance of triazole peptide-isosteres. The palladium-catalyzed glycosylation provided access to complex C-glycosides and fluorescent-labeled glycoamino acids.
The content of this RSS Feed (c) The Royal Society of Chemistry
- Facile optimization of hierarchical topography and chemistry on
magnetically active graphene oxide nanosheets
Abstract:Chem. Sci., 2020, 11,6556-6566
DOI : 10.1039/D0SC00517G, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Avijit Das, Kousik Maji, Sarajit Naskar, Uttam Manna
‘Confined-optimization’ of desired topography and appropriate chemistry on a magnetically-active and two-dimensional (2D) graphene oxide (GO) nanosheets is unprecedentedly achieved following a rapid and facile 1,4-conjugate addition reaction.
The content of this RSS Feed (c) The Royal Society of Chemistry
- Strategies for remote enantiocontrol in chiral gold(III) complexes applied
to catalytic enantioselective γ,δ-Diels–Alder reactions
Abstract:Chem. Sci., 2020, 11,6450-6456
DOI : 10.1039/D0SC00497A, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Jolene P. Reid, Mingyou Hu, Susumu Ito, Banruo Huang, Cynthia M. Hong, Hengye Xiang, Matthew S. Sigman, F. Dean Toste
Chiral square planar gold(III) complexes are employed as catalysts in asymmetric Diels–Alder reactions. The non-covalent interactions responsible for the enantioselectivity are revealed through multivariate linear regression analysis.
The content of this RSS Feed (c) The Royal Society of Chemistry
- Fine-tuning the electronic structure of heavy-atom-free BODIPY
photosensitizers for fluorescence imaging and mitochondria-targeted
photodynamic therapy
Abstract:Chem. Sci., 2020, 11,6479-6484
DOI : 10.1039/D0SC01171A, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Sujie Qi, Nahyun Kwon, Yubin Yim, Van-Nghia Nguyen, Juyoung Yoon
We designed and investigated novel mitochondria-targeting heavy-atom-free BODIPY photosensitizers (R-BODs) that possessed considerable singlet oxygen generation abilities and good fluorescence properties for imaging-guided photodynamic therapy (PDT).
The content of this RSS Feed (c) The Royal Society of Chemistry
- From reactive carbenes to chiral polyether macrocycles in two steps –
synthesis and applications made easy'
Abstract:Chem. Sci., 2020, 11,6362-6369
DOI : 10.1039/D0SC01011A, Minireview Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Alexandre Homberg, Jérôme Lacour
Chiral polyether macrocycles are versatile molecules.
The content of this RSS Feed (c) The Royal Society of Chemistry
- Mechanistic basis for tuning iridium hydride photochemistry from H2
evolution to hydride transfer hydrodechlorination
Abstract:Chem. Sci., 2020, 11,6442-6449
DOI : 10.1039/D0SC00422G, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Seth M. Barrett, Bethany M. Stratakes, Matthew B. Chambers, Daniel A. Kurtz, Catherine L. Pitman, Jillian L. Dempsey, Alexander J. M. Miller
The innate H2 evolution photochemistry of an iridium hydride complex is diverted towards photochemical hydrodechlorination of dichloromethane with high selectivity and quantum yield.
The content of this RSS Feed (c) The Royal Society of Chemistry
- Real-time tracking of the entangled pathways in the multichannel
photodissociation of acetaldehyde
Abstract:Chem. Sci., 2020, 11,6423-6430
DOI : 10.1039/D0SC00063A, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Chung-Hsin Yang, Surjendu Bhattacharyya, Lihong Liu, Wei-hai Fang, Kopin Liu
Unraveling the entangled multi-channel dissociation pathways by a two-dimensional, time and product pair-correlation, measurement and ab initio calculations.
The content of this RSS Feed (c) The Royal Society of Chemistry
- Testing the limits of radical-anionic CH-amination: a 10-million-fold
decrease in basicity opens a new path to hydroxyisoindolines via a mixed
C–N/C–O-forming cascade
Abstract:Chem. Sci., 2020, 11,6539-6555
DOI : 10.1039/C9SC06511C, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Quintin Elliott, Gabriel dos Passos Gomes, Christopher J. Evoniuk, Igor V. Alabugin
An intramolecular C(sp3)–H amidation proceeds in the presence of t-BuOK, molecular oxygen, and DMF.
The content of this RSS Feed (c) The Royal Society of Chemistry
- Designing Highly Stable Coordination-Driven Metallacycle for
Imaging-Guided Photodynamic Cancer Theranostics
Abstract: Chem. Sci., 2020, Accepted Manuscript
DOI : 10.1039/D0SC02236E, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Lizhen He, Li-Xuan Cai, Meng-Hua Li, Guanglu Zhang, Lipeng Zhou, Tianfeng Chen, Mei-Jin Lin, Qing-Fu Sun
Coordination-driven self-assembly features good predictability and directionality in the construction of discrete metallacycles and metallacages with well-defined sizes and shapes, but their medicinal application has been limited by the low...
The content of this RSS Feed (c) The Royal Society of Chemistry
- Symmetry of Three-Center, Four-Electron Bonds
Abstract: Chem. Sci., 2020, Accepted Manuscript
DOI : 10.1039/D0SC02076A, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Ann Chrisitn Reiersolmoen, Stefano Battaglia, Sigurd Øien-Ødegaard, Arvind Kumar Kumar Gupta, Anne Fiksdahl, Roland Lindh, Mate Erdelyi
Three-center, four-electron bonds provide unusually strong interactions; however, their nature remains ununderstood. Investigations of the strength, symmetry and the covalent versus electrostatic character of three-center hydrogen bonds have vastly contributed...
The content of this RSS Feed (c) The Royal Society of Chemistry
- Recent advances in low oxidation state aluminium chemistry
Abstract:Chem. Sci., 2020, Advance Article
DOI : 10.1039/D0SC02686G, Perspective Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Katie Hobson, Claire J. Carmalt, Clare Bakewell
Documenting the synthesis and isolation of novel low oxidation state aluminium (Al) compounds, which until recently has seen relatively slow progress over the 30 years since such species were first isolated.
To cite this article before page numbers are assigned, use the
DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry
- N-Heterocyclic carbene based catalytic platform for Hauser–Kraus
annulations
Abstract:Chem. Sci., 2020, Advance Article
DOI : 10.1039/D0SC03116J, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Mohammed Sharique, Uttam K. Tambar
The venerable Hauser–Kraus annulation is an effective and convergent method for generating oxygenated polycyclic aromatic compounds. A catalytic Hauser–Kraus annulation has been developed based on N-heterocyclic carbene catalysis.
To cite this article before page numbers are assigned, use the
DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry
- Asymmetry controlled dynamic behavior of autonomous chemiluminescent Janus
microswimmers
Abstract: Chem. Sci., 2020, Accepted Manuscript
DOI : 10.1039/D0SC02431G, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Gerardo Salinas, Alice L. Dauphin, Silva Voci, Laurent Bouffier, Neso Sojic, Alexander Kuhn
Asymmetrically modified Janus microparticles are presented as autonomous light emitting swimmers. The localized dissolution of hybrid magnesium/polymer objects allows combining chemiluminescence with the spontaneous production of H2 bubbles, and thus...
The content of this RSS Feed (c) The Royal Society of Chemistry
- An interparticle relatively motional DNA walker and its sensing
application
Abstract: Chem. Sci., 2020, Accepted Manuscript
DOI : 10.1039/D0SC00109K, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Hong Zhang, Xiaowen Xu, Wei Jiang
DNA molecular machines are DNA self-assemblies that perform quasi-mechanical movement at the micro-nano scale, and have attracted increasing attention in the fields of biosensing, drug delivery and biocomputing. Herein, we...
The content of this RSS Feed (c) The Royal Society of Chemistry
- A fluorescent ESIPT-based benzimidazole platform for the ratiometric
two-photon imaging of ONOO− in vitro and ex vivo
Abstract:Chem. Sci., 2020, Advance Article
DOI : 10.1039/D0SC02347G, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Maria. L. Odyniec, Sang-Jun Park, Jordan E. Gardiner, Emily C. Webb, Adam C. Sedgwick, Juyoung Yoon, Steven D. Bull, Hwan Myung Kim, Tony. D. James
In this work, we have developed an ESIPT benzimidazole-based platform for the two-photon cell imaging of ONOO− and a potential ONOO−-activated theranostic scaffold.
To cite this article before page numbers are assigned, use the
DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry
- Palladium-Catalyzed Asymmetric Hydrophosphorylation of Alkynes: Facile
Access to P‑Stereogenic Phosphinates
Abstract: Chem. Sci., 2020, Accepted Manuscript
DOI : 10.1039/D0SC01049A, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Zhiping Yang, Xiaodong Gu, Li-Biao Han, Jun Wang
Despite the importance of P-chiral organophosphorus compounds in asymmetric catalysis, transition metal catalyzed methods to access P-chiral phosphine derivatives are still limited. Herein, a catalytic enantioselective method for the synthesis...
The content of this RSS Feed (c) The Royal Society of Chemistry
- Enthalpic incompatibility between two steric stabilizer blocks provides
control over the vesicle size distribution during polymerization-induced
self-assembly in aqueous media
Abstract:Chem. Sci., 2020, Advance Article
DOI : 10.1039/D0SC01320J, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Deborah L. Beattie, Oleksandr O. Mykhaylyk, Steven P. Armes
SAXS studies confirm that a judicious binary mixture of enthalpically incompatible steric stabilizer blocks enables the synthesis of relatively small, well-defined vesicles via polymerization-induced self-assembly in aqueous media.
To cite this article before page numbers are assigned, use the
DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry
- A tumor acidity activatable and Ca2+-assisted immuno-nanoagent enhances
breast cancer therapy and suppresses cancer recurrence
Abstract: Chem. Sci., 2020, Accepted Manuscript
DOI : 10.1039/D0SC00293C, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Yanhua Li, Shaohua Gong, Wei Pan, Yuanyuan Chen, Bo Liu, Na Li, Bo Tang
Breast cancer recurrence is the greatest contributor to patient death. As the immune system has a long-term immune memory effect, immunotherapy has great potential for preventing cancer recurrence. However, cancer...
The content of this RSS Feed (c) The Royal Society of Chemistry
- Endowing TADF luminophors with AIE properties through adjusting flexible
dendrons for highly efficient solution-processed nondoped OLEDs
Abstract:Chem. Sci., 2020, Advance Article
DOI : 10.1039/D0SC02194F, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Dan Liu, Jing Yi Wei, Wen Wen Tian, Wei Jiang, Yue Ming Sun, Zheng Zhao, Ben Zhong Tang
Construction of core–dendron TADF emitters systematically: changing the behaviour of chromophores from aggregation-caused quenching to aggregation induced emission to develop high-performance fully solution-processed nondoped OLEDs.
To cite this article before page numbers are assigned, use the
DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry
- Heterometallic Multinuclear Nodes Directing MOF Electronic Behavior
Abstract: Chem. Sci., 2020, Accepted Manuscript
DOI : 10.1039/D0SC03053H, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Otega Ejegbavwo, Anna A. Berseneva, Corey R. Martin, Gabrielle A. Leith, Shubham Pandey, Amy J. Brandt, Kyoung Chul Park, Abhijai Mathur, Sharfa Farzandh, Vladislav Klepov, Brittany J Heiser, Mvs Chandrashekhar, Stavros Karakalos, Mark D. Smith, Phillpot R Simon, Sophya Garashchuk, Donna A. Chen, Natalia Shustova
Metal node engineering in combination with modularity, topological diversity, and porosity of metal-organic frameworks (MOFs) could advance energy and optoelectronic sectors. In this study, we focus on MOFs with multinuclear...
The content of this RSS Feed (c) The Royal Society of Chemistry
- Chimeric Oligosaccharide Conjugate Induces Opsonic Antibodies against
Streptococcus pneumonia serotypes 19A and 19F
Abstract: Chem. Sci., 2020, Accepted Manuscript
DOI : 10.1039/D0SC02230F, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Someswara Rao Sanapala, Bruna M. S. Seco, Ju Yuel Baek, Shahid I. Awan, Claney L. Pereira, Peter Seeberger
Streptococcus pneumoniae 19A (ST19A) and 19F (ST19F) are among the prevalent serotypes causing pneumococcal disease worldwide even after introduction of a 13-valent pneumococcal conjugate vaccine (PCV13). Synthetic glycoconjugate vaccines have...
The content of this RSS Feed (c) The Royal Society of Chemistry
- Diagnosing Surface versus Bulk Reactivity for Molecular Catalysis within
Metal-Organic Frameworks using a Quantitative Kinetic Model
Abstract: Chem. Sci., 2020, Accepted Manuscript
DOI : 10.1039/D0SC02601H, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Ben A. Johnson, Sascha Ott
Metal-organic frameworks (MOFs) are becoming increasingly popular as heterogenous support matrices for molecular catalysts. Given that reactants, or potentially holes/electrons, need to diffuse into the porous framework as the reaction...
The content of this RSS Feed (c) The Royal Society of Chemistry
- Macrocycle synthesis strategy based on step-wise "adding and reacting"
three components enables screening of large combinatorial libraries
Abstract: Chem. Sci., 2020, Accepted Manuscript
DOI : 10.1039/D0SC01944E, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Ganesh Kumar Mothukuri, Sangram S Kale, Carl Leonard Stenbratt, Alessandro Zorzi, Jonathan Vesin, Julien Bortoli Chapalay, Kaycie Deyle, Gerardo Turcatti, Laura Cendron, Alessandro Angelini, Christian Heinis
Macrocycles provide an attractive modality for drug development, but generating ligands for new targets is hampered by the limited availability of large macrocycle libraries. We have established a solution-phase macrocycle...
The content of this RSS Feed (c) The Royal Society of Chemistry
- Selective oxo ligand functionalisation and substitution reactivity in an
oxo/catecholate-bridged UIV/UIV Pacman complex
Abstract:Chem. Sci., 2020, Advance Article
DOI : 10.1039/D0SC02297G, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Bradley E. Cowie, Iskander Douair, Laurent Maron, Jason B. Love, Polly L. Arnold
A UIV/UIV “Pacman” complex exhibits facile oxo-ligand functionalisation and substitution reactivity, owing to a bridging catecholate ligand that enhances the μ-oxo nucleophilicity and stabilises the resulting products.
To cite this article before page numbers are assigned, use the
DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry
- Structural Determinants of Macrocyclization in Substrate-Controlled
Lanthipeptide Biosynthetic Pathways
Abstract: Chem. Sci., 2020, Accepted Manuscript
DOI : 10.1039/D0SC01651A, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Silvia C. Bobeica, Lingyang Zhu, Jeella Acedo, Weixin Tang, Wilfred A van der Donk
Lanthipeptides are characterized by thioether crosslinks formed by post-translational modifications. The cyclization process that favors a single ring pattern over many other possible ring patterns has been the topic of...
The content of this RSS Feed (c) The Royal Society of Chemistry
- Solar-driven tandem photoredox nickel-catalysed cross-coupling using
modified carbon nitride
Abstract: Chem. Sci., 2020, Accepted Manuscript
DOI : 10.1039/D0SC02131H, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Yangzhong Qin, Benjamin C. M. Martindale, Rui Sun, Adam J Rieth, Daniel G. Nocera
Nickel-catalyzed aryl amination and etherification are driven with sunlight using a surface-modified carbon nitride to extend the absorption of the photocatalyst into a wide range of the visible region. In...
The content of this RSS Feed (c) The Royal Society of Chemistry
- Build-Up of Double Carbohelicenes Using Nitroarenes: Dual Role of the
Nitro Functionality as Activation and Leaving Group
Abstract: Chem. Sci., 2020, Accepted Manuscript
DOI : 10.1039/D0SC02058C, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Fulin Zhou, Fujian Zhou, Rongchuan Su, Yudong Yang, Jingsong You
The construction of double carbohelicenes is a highly fascinating yet challenging work. Disclosed herein is a streamlined and simplified synthetic route to double carbohelicenes starting from nitroarenes through sequential nitro-activated...
The content of this RSS Feed (c) The Royal Society of Chemistry
- Revealing the Molecular Mechanisms of Proteolysis of SARS-CoV-2 Mpro from
QM/MM Computational Methods.
Abstract: Chem. Sci., 2020, Accepted Manuscript
DOI : 10.1039/D0SC02823A, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Katarzyna Świderek, Vicent Moliner
SARS-CoV-2 Mpro is one of the enzymes essential for the replication process of the virus responsible of the COVID-19 pandemic. This work is focused on exploring its proteolysis reaction by means...
The content of this RSS Feed (c) The Royal Society of Chemistry
- Pnictogen-bonding catalysis: brevetoxin-type polyether cyclizations
Abstract:Chem. Sci., 2020, Advance Article
DOI : 10.1039/D0SC02551H, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Andrea Gini, Miguel Paraja, Bartomeu Galmés, Celine Besnard, Amalia I. Poblador-Bahamonde, Naomi Sakai, Antonio Frontera, Stefan Matile
This study marks chemical space available for pnictogen-bonding catalysis, and demonstrates that reactivity accessible in this space is unique.
To cite this article before page numbers are assigned, use the
DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry
- Radical condensation between benzylic alcohols and acetamides to form
3-arylpropanamides
Abstract: Chem. Sci., 2020, Accepted Manuscript
DOI : 10.1039/D0SC02948C, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Kobra Azizi, Robert Madsen
A new radical condensation reaction is developed where benzylic alcohols and acetamides are coupled to generate 3-arylpropanamides with water as the only byproduct. The transformation is performed with potassium tert-butoxide...
The content of this RSS Feed (c) The Royal Society of Chemistry
- Molecular chirality mediated amyloid formation on phospholipid surfaces
Abstract: Chem. Sci., 2020, Accepted Manuscript
DOI : 10.1039/D0SC02212H, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Xue Wang, Cunli Wang, Huiying Chu, Haijuan Qin, Dongdong Wang, Feifei Xu, Xuanjun Ai, Chunshan Quan, Guo-Hui Li, Guangyan Qing
One of the neuropathological features of Alzheimer's disease (AD) is misfolding of amyloid-β to form amyloid aggregates, a process highly associated with biological membranes. However, how molecular chirality affects the...
The content of this RSS Feed (c) The Royal Society of Chemistry
- In situ K-edgeX-ray absorption spectroscopy of the ligand environment of
single-site Au/C catalysts during acetylene hydrochlorination.
Abstract: Chem. Sci., 2020, Accepted Manuscript
DOI : 10.1039/D0SC02152K, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Grazia Malta, Simon Kondrat, Simon Freakley, David John Morgan, Emma K Gibson, Peter Philip Wells, Matteo Aramini, Diego Gianolio, Paul Thompson, Peter Johnston, Graham Hutchings
The replacement of HgCl2/C with Au/C as a catalyst for acetylene hydrochlorination represents a significant reduction in the environmental impact of this industrial process. Under reaction conditions atomically dispersed cationic...
The content of this RSS Feed (c) The Royal Society of Chemistry
- Neural Network Activation Similarity: A New Measure to Assist Decision
Making in Chemical Toxicology
Abstract: Chem. Sci., 2020, Accepted Manuscript
DOI : 10.1039/D0SC01637C, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Timothy Eric Harry Allen, Andrew J Wedlake, Elena Gelžinytė, Charles Gong, Jonathan Goodman, Steve Gutsell, Paul J Russell
Deep learning neural networks, constructed for the prediction of chemical binding at 79 pharmacologically important human biological targets, show extremely high performance on test data (accuracy 92.2 ± 4.2%, MCC...
The content of this RSS Feed (c) The Royal Society of Chemistry
- Late-stage and strain-accelerated oxidation enabled synthesis of haouamine
A
Abstract:Chem. Sci., 2020, Advance Article
DOI : 10.1039/D0SC02299C, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Kun Ho (Kenny) Park, Antonio Rizzo, David Y.-K. Chen
Synthesis of the strained cyclophane alkaloid haouamine A has been accomplished via a late-stage and strain-accelerated oxidation to access the challenging biphenol cyclophane system.
To cite this article before page numbers are assigned, use the
DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry
- Dual Catalytic Enantioselective Desymmetrization of Allene-Tethered
Cyclohexanones
Abstract: Chem. Sci., 2020, Accepted Manuscript
DOI : 10.1039/D0SC02878A, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Lin Zhang, Ken Yamazaki, Jamie Leitch, Ruben Manzano, Victoria A. M. Atkinson, Trevor A. Hamlin, Darren Dixon
The construction of enantioenriched azabicyclo[3.3.1]nonan-6-one heterocycles via an enantioselective desymmetrization of allene-linked cyclohexanones, enabled through a dual catalytic system, that provides synchronous activation of the cyclohexanone with a chiral prolinamide...
The content of this RSS Feed (c) The Royal Society of Chemistry
- Pyrazolone Ligation-Mediated Versatile Sequential Bioconjugations
Abstract: Chem. Sci., 2020, Accepted Manuscript
DOI : 10.1039/D0SC02466J, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Melrose Mailig, Fa Liu
Bioconjugation chemistries are critical tools in biotherapeutics discovery. The past efforts have been exclusively focused on two-segment conjugations. However, emerging research directions, such as polypharmacy biotherapeutics, desire multiple-component bioconjugations where...
The content of this RSS Feed (c) The Royal Society of Chemistry
- Ti-Catalyzed Ring-Opening Oxidative Amination of Methylenecyclopropanes
with Diazenes
Abstract: Chem. Sci., 2020, Accepted Manuscript
DOI : 10.1039/D0SC01998D, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Evan P Beaumier, Amy A Ott, Xuelan Wen, Zachary W Davis-Gilbert, Thomas A Wheeler, Joseph J Topczewski, Jason D. Goodpaster, Ian Tonks
The ring-opening oxidative amination of methylenecyclopropanes (MCPs) with diazenes catalyzed by py3TiCl2(NR) complexes is reported. This reaction selectively generates branched α-methylene imines as opposed to linear α,β-unsaturated imines, which are...
The content of this RSS Feed (c) The Royal Society of Chemistry
- Site-selective aromatic C–H λ3-iodanation with cyclic iodine(III)
electrophile in solution and solid phases
Abstract: Chem. Sci., 2020, Accepted Manuscript
DOI : 10.1039/D0SC02737E, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Wei Ding, Chen Wang, Jie Ren Tan, Chang Chin Ho, Felix León, Felipe Garcia, Naohiko Yoshikai
An efficient and site-selective aromatic C–H λ3-iodanation reaction is achieved using benziodoxole triflate (BXT) as electrophile under room temperature conditions. The reaction tolerates a variety of electron-rich arenes and heteroarenes...
The content of this RSS Feed (c) The Royal Society of Chemistry
- Chiral Information Harvesting in Helical Poly(acetylene) Derivatives Using
Oligo(p-phenyleneethynylene)s as Spacers
Abstract: Chem. Sci., 2020, Accepted Manuscript
DOI : 10.1039/D0SC02685A, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Zulema Fernandez, Berta Fernández, Emilio Quiñoá, Ricardo Riguera, Felix Freire
A chiral harvesting transmission mechanism is described in poly(acetylene)s bearing oligo(p-phenyleneethynylene)s (OPEs) used as rigid achiral spacers and derivatized with a chiral pendant groups. The chiral moieties induce a positive...
The content of this RSS Feed (c) The Royal Society of Chemistry
- Nanostructured liquid-crystalline Li-ion conductors with high oxidation
resistance: molecular design strategy towards safe and
high-voltage-operation Li-ion batteries
Abstract: Chem. Sci., 2020, Accepted Manuscript
DOI : 10.1039/D0SC01646B, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Takashi Kato, Atsushi Kuwabara, Mayu Enomoto, Eiji Hosono, Kazuma Hamaguchi, Taira Onuma, Satoshi Kajiyama
Nanostructured, uncharged liquid-crystalline (LC) electrolyte molecules having bicyclohexyl and cyclic carbonate moieties have been developed for application in Li-ion batteries as quasi-solid electrolytes, which suppress leakage and combustion. Towards the...
The content of this RSS Feed (c) The Royal Society of Chemistry
- Catalytic Enantioselective Synthesis of Carbocyclic and Heterocyclic
Spiranes via a Decarboxylative Aldol Cyclization
Abstract: Chem. Sci., 2020, Accepted Manuscript
DOI : 10.1039/D0SC02366C, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Kazato Inanaga, Marco Wollenburg, Shoshana Bachman, Nicholas Hafeman, Brian M. Stoltz
The synthesis of a variety of enantioenriched 1,3-diketospiranes from the corresponding racemic allyl β-ketoesters via an interrupted asymmetric allylic alkylation is disclosed. Substrates possessing pendant aldehydes undergo decarboxylative enolate formation in the...
The content of this RSS Feed (c) The Royal Society of Chemistry
- Conversion between Triplet Pair States is Controlled by Molecular Coupling
in Pentadithiophene Thin Films
Abstract: Chem. Sci., 2020, Accepted Manuscript
DOI : 10.1039/D0SC02497J, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Natalie Pace, Brandon K. Rugg, Christopher H Chang, Obadiah Reid, Karl J Thorley, Sean R. Parkin, John E. Anthony, Justin C. Johnson
In singlet fission (SF) the initially formed correlated triplet pair state, 1(TT), may evolve toward independent triplet excitons or higher spin states of the (TT) species. The latter result is...
The content of this RSS Feed (c) The Royal Society of Chemistry
- Cobalt-Catalyzed Aminocarbonylation of (Hetero)Aryl Halides Promoted by
Visible Light
Abstract: Chem. Sci., 2020, Accepted Manuscript
DOI : 10.1039/D0SC02178D, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Alexander Veatch, Erik Alexanian
The catalytic aminocarbonylation of (hetero)aryl halides is widely applied in the synthesis of amides but relies heavily on the use of precious metal catalysis. Herein, we report an aminocarbonylation of...
The content of this RSS Feed (c) The Royal Society of Chemistry
- Palladium-catalyzed synthesis of β-hydroxy compounds via a strained
6,4-palladacycle from directed C−H activation of anilines and C-O
insertion of epoxides
Abstract: Chem. Sci., 2020, Accepted Manuscript
DOI : 10.1039/D0SC01462A, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Raju S Thombal, Taisiia Feoktistova, Gisela A. González-Montiel, Paul H-Y Cheong, Yong Rok Lee
A palladium-catalyzed C−H activation of acetylated anilines (acetanilides, 1,1-dimethyl-3-phenylurea, 1-phenylpyrrolidin-2-one, and 1-(indolin-1-yl)ethan-1-one) with epoxides using O-coordinating directing groups was accomplished. This C−H alkylation reaction proceeds via formation of a previously...
The content of this RSS Feed (c) The Royal Society of Chemistry
- Synthesis of oxalamides by acceptorless dehydrogenative coupling of
ethylene glycol and amines and the reverse hydrogenation catalyzed by
ruthenium
Abstract: Chem. Sci., 2020, Accepted Manuscript
DOI : 10.1039/D0SC02065F, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.You-Quan Zou, Quan-Quan Zhou, Yael Diskin-Posner, Yehoshoa Ben-David, David Milstein
A sustainable, new synthesis of oxalamides, by acceptorless dehydrogenative coupling of ethylene glycol with amines, generating H2, homogeneously catalyzed by a ruthenium pincer complex, is presented. The reverse hydrogenation reaction...
The content of this RSS Feed (c) The Royal Society of Chemistry
- Direct Catalytic Asymmetric and Anti-selective Vinylogous Addition of
Butenolides to Chromones
Abstract: Chem. Sci., 2020, Accepted Manuscript
DOI : 10.1039/D0SC01914C, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Jin Cui, Naoya Kumagai, Takumi Watanabe, Masakatsu Shibasaki
An anti-selective catalytic asymmetric Michael-type vinylogous addition of β,γ-butenolides to chromones was developed. The catalyst system developed herein is characterized by tuning of the steric and electronic effects using a...
The content of this RSS Feed (c) The Royal Society of Chemistry
- Visible-Light Activated [2+2] Cycloaddition Reaction Enables Pinpointing
Carbon-Carbon Double Bonds in Lipids
Abstract: Chem. Sci., 2020, Accepted Manuscript
DOI : 10.1039/D0SC01149E, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Guifang Feng, Yanhong Hao, Liang Wu, Suming Chen
The precise location of C=C bonds in bioactive molecules is critical for deep understanding the relationship between their structures and biological roles. However, the traditional ultraviolet light-based approaches exhibited great...
The content of this RSS Feed (c) The Royal Society of Chemistry
- Small molecule-mediated co-assembly of amyloid-β oligomers reduces
neurotoxicity through promoting non-fibrillar aggregation
Abstract: Chem. Sci., 2020, Accepted Manuscript
DOI : 10.1039/D0SC00392A, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Hao Liu, Chengyuan Qian, Tao Yang, Yanqing Wang, Jian Luo, Changli Zhang, Xiaohui Wang, Xiaoyong Wang, Zijian Guo
Amyloid-β (Aβ) oligomers, particularly low molecular weight (LMW) oligomers, rather than fibrils, contribute very significantly to the onset and progression of Alzheimer’s disease (AD). However, due to the inherent heterogeneity...
The content of this RSS Feed (c) The Royal Society of Chemistry
- Prediction of NHC-catalyzed chemoselective functionalizations of carbonyl
compounds: A general mechanistic map
Abstract: Chem. Sci., 2020, Accepted Manuscript
DOI : 10.1039/D0SC01793K, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Xue Li, Yu Lan, Jun Xu, Donghui Wei, Shi-Jun Li, Lingbo Qu, Zhongjun Li, Yonggui Robin Chi
Generally, N-heterocyclic carbene (NHC) complexed with carbonyl compounds would transform into several important active intermediates, i.e., enolate, Breslow intermediate, or acylazolium intermediate, which act as either a nucleophile (Nu) or...
The content of this RSS Feed (c) The Royal Society of Chemistry
- Enhancing biocompatibility of rhodamine fluorescent probes by a
neighbouring group effect
Abstract: Chem. Sci., 2020, Accepted Manuscript
DOI : 10.1039/D0SC02154G, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Jonas Bucevicius, Georgij Kostiuk, Ruta Gerasimaite, Tanja Gilat, Grazvydas Lukinavicius
Fluorescence microscopy is an essential tool for understanding dynamic processes in living cells and organisms. However, many fluorescent probes for labelling cellular structures suffer from unspecific interactions and low cell...
The content of this RSS Feed (c) The Royal Society of Chemistry
- A Neutral Porous Organic Polymer Host for the Recognition of Anionic Dyes
in Water
Abstract: Chem. Sci., 2020, Accepted Manuscript
DOI : 10.1039/D0SC02941F, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Whitney Shin Yi Ong, Ronald Alexander Smaldone, Sheel Dodani
Neutral hosts for the recognition of anionic guests in water remain underdeveloped due to the inherent thermodynamic barrier for desolvation. To address this challenge, we have repurposed crosslinked porous organic...
The content of this RSS Feed (c) The Royal Society of Chemistry
- BNN-1,3-dipoles: isolation and intramolecular cycloaddition with
unactivated arenes
Abstract: Chem. Sci., 2020, Accepted Manuscript
DOI : 10.1039/D0SC02162H, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Rui Guo, Jingxing Jiang, Chenyang Hu, Liu Leo Liu, Ping Cui, Meihua Zhao, Zhuofeng Ke, Chen-Ho Tung, Lingbing Kong
The mono-base-stabilized 1,2-diboranylidenehydrazine derivatives featuring a 1,3-dipolar BNN skeleton are obtained by dehydrobromination of [ArB(Br)NH]2 (Ar = 2,6-diphenylphenyl (Dpp), Ar = 2,6-bis(2,4,6-trimethylphenyl)phenyl (Dmp) or Ar = 2,4,6-tri-tert-butylphenyl (Mes*)) with N-heterocyclic...
The content of this RSS Feed (c) The Royal Society of Chemistry
- Reactions of an Anionic Chelate Phosphane/borata-alkene Ligand with
[Rh(nbd)Cl]2, [Rh(CO)2Cl]2 and [Ir(cod)Cl]2.
Abstract: Chem. Sci., 2020, Accepted Manuscript
DOI : 10.1039/D0SC02223C, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Kohei Watanabe, Atsushi Ueno, Xin Tao, Karel Skoch, Xiaoming Jie, Sergei Vagin, Bernhard Rieger, Constantin Gabriel Daniliuc, Mathias C. Letzel, Gerald Kehr, Gerhard Erker
Borata-alkenes can serve as anionic olefin equivalent ligands in transition metal chemistry. A chelate ligand of this type is described and used for metal coordination. Deprotonation of the Mes2P(CH2)2B(C6F5)2 frustrated...
The content of this RSS Feed (c) The Royal Society of Chemistry
- Integrating CRISPR-Cas12a with DNA Circuit as A Generic Sensing Platform
for Amplified Detection of MicroRNA
Abstract: Chem. Sci., 2020, Accepted Manuscript
DOI : 10.1039/D0SC03084H, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Shuang Peng, Zhen Tan, Siyu Chen, Chunyang Lei, Zhou Nie
CRISPR-based diagnostics (CRISPR-Dx) has shown great promise in molecular diagnostics, but its utility in the sensing of microRNA (miRNA) biomarkers is limited by sensitivity, cost and robustness. Here, we describe...
The content of this RSS Feed (c) The Royal Society of Chemistry
- Total Synthesis of Crotophorbolone
Abstract: Chem. Sci., 2020, Accepted Manuscript
DOI : 10.1039/D0SC02829K, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Tianzi Yu, Ying Sun, Canhui Tu, Ting Chen, Shaomin Fu, Bo Liu
As a natural diterpenoid, crotophorbolone possesses a challenging trans,trans-5/7/6 framework decorated with six contiguous stereogenic centers, which is structurally and biogenetically related to tigliane-type diterpenoids with intriguing bioactivities such as...
The content of this RSS Feed (c) The Royal Society of Chemistry
- Efficient and Selective Alkene Hydrosilation Promoted by Weak, Double
Si–H Activation at an Iron Center
Abstract: Chem. Sci., 2020, Accepted Manuscript
DOI : 10.1039/D0SC01749C, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Patrick Smith, Yuyang Dong, T. Don Tilley
Cationic iron complexes [Cp*(iPr2MeP)FeH2SiHR]+, generated and characterized in solution, are very efficient catalysts for the hydrosilation of terminal alkenes and internal alkynes by primary silanes at low catalyst loading (0.1...
The content of this RSS Feed (c) The Royal Society of Chemistry
- Conformationally Adaptable Macrocyclic Receptors for Ditopic Anions:
Analysis of Chelate Cooperativity in Aqueous Containing Media
Abstract: Chem. Sci., 2020, Accepted Manuscript
DOI : 10.1039/D0SC02533J, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Stuart N. Berry, Lei Qin, William Lewis, Katrina A. Jolliffe
The effect of chelate cooperativity on the binding of several ditopic anions to two tetrathiourea macrocycles has been analysed in competitive solvent mixtures (H2O:DMSO 1:9 v/v). The semi-flexible receptors bind...
The content of this RSS Feed (c) The Royal Society of Chemistry
- Structure and Solvation of Confined Water and Water-Ethanol Clusters
within Microporous Brønsted Acids and their Effects on Ethanol
Dehydration Catalysis
Abstract: Chem. Sci., 2020, Accepted Manuscript
DOI : 10.1039/D0SC02589E, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Jason S. Bates, Brandon Bukowski, Jeffrey P. Greeley, Rajamani Gounder
Aqueous-phase reactions within microporous Brønsted acids occur at active centers comprised of water-reactant-clustered hydronium ions, solvated within extended hydrogen-bonded water networks that tend to stabilize reactive intermediates and transition states...
The content of this RSS Feed (c) The Royal Society of Chemistry
- Targeted classification of metal-organic frameworks in the Cambridge
structural database (CSD)
Abstract: Chem. Sci., 2020, Accepted Manuscript
DOI : 10.1039/D0SC01297A, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Peyman Z Moghadam, Aurelia Li, Xiao-Wei Liu, Rocio Bueno-Perez, Shudong Wang, Seth Wiggin, Peter Andrew Wood, David Fairen-Jimenez
Large-scale targeted exploration of metal-organic frameworks (MOFs) with characteristics such as specific surface chemistry or metal-cluster family has not been investigated so far. These definitions are particularly important because they...
The content of this RSS Feed (c) The Royal Society of Chemistry
- Templating S100A9 amyloids on Aβ fibrillar surfaces revealed by charge
detection mass spectrometry, microscopy, kinetic and microfluidic analyses
Abstract: Chem. Sci., 2020, Accepted Manuscript
DOI : 10.1039/C9SC05905A, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Jonathan Pansieri, Igor Iashchishyn, Hussein Fakhouri, Lucija Ostojić, Mantas MM Malisauskas, Greta Musteikyte, Vytautas Smirnovas, Matthias M. Schneider, Tom Scheidt, Catherine K. Xu, Georg Meisl, Ehut Gazit, Rodolphe Antoine, Ludmilla A. Morozova-Roche
The mechanism of amyloid co-aggregation and its nucleation process are not fully understood in spite of extensive studies. Deciphering the interactions between proinflammatory S100A9 protein and Aβ42 peptide in Alzheimer's...
The content of this RSS Feed (c) The Royal Society of Chemistry
- Effect of Heterocycle Content on Metal Binding Isostere Coordination
Abstract: Chem. Sci., 2020, Accepted Manuscript
DOI : 10.1039/D0SC02717K, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Benjamin L Dick, Ashay Patel, Seth M Cohen
Bioisostere replacement is a core concept in modern medicinal chemistry and has proven an invaluable strategy to address pharmacodynamic and pharmacokinetic limitations of therapeutics. The success of bioisostere replacement is...
The content of this RSS Feed (c) The Royal Society of Chemistry
- Panchromatic Light Funneling through the Synergy in
Hexabenzocoronene–(Metallo)porphyrin–Fullerene Assemblies to Realize
the Separation of Charges
Abstract: Chem. Sci., 2020, Accepted Manuscript
DOI : 10.1039/D0SC02028A, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Maximilian Wolf, Dominik Lungerich, Stefan Bauroth, Maximilian Popp, Benedikt Platzer, Tim Clark, Harry Laurence Anderson, Norbert Jux, Dirk M. Guldi
Here, we present a novel butadyine-linked HBC-ethynyl-porphyrin dimer, which exhibits in the ground state strong absorption cross sections throughout the UV and visible ranges of the solar spectrum. In short,...
The content of this RSS Feed (c) The Royal Society of Chemistry
- Mutation effects on charge transport through the p58c iron-sulfur protein
Abstract: Chem. Sci., 2020, Accepted Manuscript
DOI : 10.1039/D0SC02245D, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Ruijie Darius Teo, Agostino Migliore, David N Beratan
Growing experimental evidence indicates that iron-sulfur proteins play key roles in DNA repair and replication. In particular, charge transport between [Fe4S4] clusters, mediated by proteins and DNA, may convey signals...
The content of this RSS Feed (c) The Royal Society of Chemistry
- Biomineralized Metal-Organic Framework Nanoparticles Enable a Primer
Exchange Reaction-Based DNA Machine to Work in Living Cells for Imaging
and Gene Therapy
Abstract: Chem. Sci., 2020, Accepted Manuscript
DOI : 10.1039/D0SC00339E, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Juan Zhang, Mengyun He, Cun-Peng Nie, Manman He, Qingshan Pan, Chang Liu, Yan-lei Hu, Ting-ting Chen, Xia Chu
Sensitive tumor imaging and precise tumor therapy play critical roles in the cancer combat. Herein, we build a DNA machine based on primer exchange reaction (PER) for the mRNA imaging...
The content of this RSS Feed (c) The Royal Society of Chemistry
- Carbon-based Antiviral Nanomaterials, Graphene, C-dots and Fullerenes. A
perspective
Abstract: Chem. Sci., 2020, Accepted Manuscript
DOI : 10.1039/D0SC02658A, Perspective Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Plinio Innocenzi, Luigi Stagi
The appearance of new and lethal viruses and their potential threat urgently requires innovative antiviral systems. In addition to the most common and proven pharmacological methods, nanomaterials can represent alternative...
The content of this RSS Feed (c) The Royal Society of Chemistry
