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Chemical Science [SJR: 4.974] [H-I: 79] [22 followers] Follow  Open Access journalISSN (Print) 1478-6524 - ISSN (Online) 2041-6520 Published by RSC  [43 journals]
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- Bright sensitive ratiometric fluorescent probe enabling endogenous FA
imaging and mechanistic exploration of indirect oxidative damage of FA in
various living systems
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC03719H, Edge Article
Open Access 
This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. KUN DOU, Guang Chen, Fabiao Yu, Yuxia Liu, Lingxin Chen, Ziping Cao, Tao Chen, Yulin Li, Jinmao You
As a notorious toxin, formaldehyde (FA) poses immense threat to human health. Aberrantly elevated FA leads to serious pathologies including organism damage, neurodegeneration, and cancer. Unfortunately, current techniques limit FA...
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- Intramolecular Substitution Uncages Fluorogenic Probes for Detection of
Metallo-Carbapenemase-Expressing Bacteria
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC02416A, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Aiguo Song, Yunfeng Cheng, Jinghang Xie, Niaz Banaei, Jianghong Rao
This work reports a novel caging strategy for designing fluorogenic probes and its application for detecting the activity of [small beta]-lactamases. The caging strategy uses a thiophenyl linker connected to a...
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- Chemoenzymatic synthesis of heparan sulfate and heparin oligosaccharides
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC03541A, Edge Article Open Access 
This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Xing Zhang, Vijayakanth Pagadala, Hannah M. Jester, Andrew M. Lim, Truong Quang Pham, Anna Marie Panagiotis Goulas, Jian Liu, Robert J. Linhardt
Heparan sulfate (HS) is a member of the glycosaminoglycans (GAG) family that plays essential roles in biological processes from animal sources. Heparin, a highly sulfated form of HS, is widely...
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- Displacement and Hybridization Reactions in Aptamer-functionalized
Hydrogels for Biomimetic Protein Release and Signal Transduction
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC03023A, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Jinping Lai, Shihui Li, Xuechen Shi, James Coyne, Nan Zhao, Fengping Dong, Yingwei Mao, Yong Wang
A variety of hydrogels have been synthesized for controlling the release of signaling molecules in applications such as drug delivery and regenerative medicine. However, it remains challenging to synthesize hydrogels...
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- Biosynthesis of methyl-proline containing griselimycins, natural products
with anti-tuberculosis activity
Abstract:Chem. Sci. , 2017, Advance Article
DOI : 10.1039/C7SC02622F, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Peer Lukat, Yohei Katsuyama, Silke Wenzel, Tina Binz, Claudia Konig, Wulf Blankenfeldt, Mark Bronstrup, Rolf Muller
The biosynthesis of griselimycins in Streptomyces DSM 40835 and the pathway that stereospecifically converts L -leucine to (2 S ,4 R )-4-methyl-proline are reported by means of biochemical and structural analysis.
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- Second-order nonlinear optical switch with the record-high contrast for a
photochromic and thermochromic bistable crystal
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC01228D, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Xiu-Shuang Xing, Rongjian Sa, Pei-Xin Li, Ning-Ning Zhang, Zhong-Yuan Zhou, Bin-Wen Liu, Jie Liu, Ming-Sheng Wang, Guo-Cong Guo
Nonlinear optical (NLO) switchable materials are important for photonic and optoelectronic technologies. One important issue for NLO photoswitching, the most studied physical switching approach, is how to improve switching contrasts...
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- Nanomolar small-molecule detection using a genetically encoded 129Xe NMR
contrast agent
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC03601A, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Benjamin Roose, Serge Zemerov, Ivan Dmochowski
Genetically encoded magnetic resonance imaging (MRI) contrast agents enable non-invasive detection of specific biomarkers in vivo. Here, we employed the hyper-CEST 129Xe NMR technique to quantify maltose (32 nM-1 mM)...
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- Electrochemical Recognition and Quantification of Cytochrome c Expression
in Bacillus subtilis and aerobe/anaerobe Escherichia coli using
N,N,N',N'-tetramethyl-para-phenylene-diamine (TMPD)
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC03498A, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Sabine Kuss, Eden Elizabeth Louise Tanner, Maria Ordovas-Montanes, Richard G Compton
The colorimetric identification of pathogenic and non-pathogenic bacteria in cell culture is commonly performed using the redox mediator N,N,N',N'-tetramethyl-para-phenylene-diamine (TMPD) in the so-called oxidase test, which indicates the presence of...
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- Hydrogen generation from methanol at near-room temperature
Abstract:Chem. Sci. , 2017, Advance Article
DOI : 10.1039/C7SC01778B, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Yangbin Shen, Yulu Zhan, Shuping Li, Fandi Ning, Ying Du, Yunjie Huang, Ting He, Xiaochun Zhou
We successfully designed an effective strategy to fully convert methanol to hydrogen for at least 1900[space]min ([similar]32 h) at near-room temperature.
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- A functionalized metal-organic framework decorated with O- groups showing
excellent performance for lead(II) removal from aqueous solution
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC03308G, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Hongwei Hou, Cai-Xia Yu, Chao Zhi Shao
Heavy metal ions are highly toxic and widely spread as environmental pollutants. New strategies are being developed to efficiently remove these toxic ions. Herein, we take the intrinsic advantages of...
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- An Acidic pH Independent Piperazine-TPE AIEgen as a Unique Bioprobe for
Lysosome Tracing
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC03515B, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Yuanjing Cai, Chen Gui, Kerim Samedov, Huifang Su, Xinggui Gu, Shiwu Li, Wenwen Luo, Herman H-Y. Sung, Jacky Wing Yip Lam, Ryan T. K. Kwok, Ian Duncan Williams, Anjun Qin, Ben Zhong Tang
Lysosomes are involved in a multitude of cellular processes and their dysfunction is associated with various diseases. They are the most acidic organelles (pH 3.8-6.6, size 0.1-1.2 [small mu ]m) with the...
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- Addressing the Autofluorescence Issue in Deep Tissue Imaging by Two-Photon
Microscopy: Significance of Far-Red Emitting Dyes
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC03362A, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Yong Woong Jun, Hye Rim Kim, Ye Jin Reo, Mingchong Dai, Kyo Han Ahn
Fluorescence imaging of tissue is essential for studying biological events beyond the cellular level. Two-photon microscopy based on nonlinear light absorption of fluorescent dyes is a viable tool for high...
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- Tuning Stereo-hindrance of Curcumin Scaffold for Selective Imaging of
Soluble Forms of Amyloid Beta Species
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC02050C, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Yuyan Li, Jian Yang, Hongwu Liu, Jing Yang, Lei Du, Haiwei Feng, Yanli Tian, jianqin Cao, Chongzhao Ran
Amyloid peptides and proteins are associated with pathologies of numerous diseases. In the progression of a disease, amyloids exist in soluble and insoluble forms, which are dominated species at different...
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- Nb2[copyright sign]Au6: A Molecular Wheel with a Short Nb[identical
with]Nb Triple Bond Coordinated by an Au6 Ring and Reinforced by [sigma]
Aromaticity
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC02881D, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Tian Jian, Ling Fung Cheung, Joseph Czekner, Teng-Teng Chen, Gary V. Lopez, Weili Li, Lai-Sheng Wang
We report a photoelectron spectroscopy and high-resolution photoelectron imaging study of a bimetallic Nb2Au6- cluster. Theoretical calculations, in conjunction with the experimental data, reveal that Nb2Au6-/0 possess high-symmetry D6h structures...
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- Magnetic control of cellular processes using biofunctional nanoparticles
Abstract:Chem. Sci. , 2017, Advance Article
DOI : 10.1039/C7SC01462G, Minireview Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Cornelia Monzel, Chiara Vicario, Jacob Piehler, Mathieu Coppey, Maxime Dahan
Remote control of cellular functions via mechanical, thermal or molecular stimulation is accomplished using biofunctional magnetic nanoparticles (MNPs) and magnetic fields.
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- A Mitochondrial-Targeted Prodrug for NIR Imaging Guided and Synergetic NIR
Photodynamic-Chemo Cancer Therapy
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC03454G, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Hongwen Liu, Xiaoxiao Hu, Ke Li, Yongchao Liu, Longmin Zhu, Qiming Rong, Lin Yuan, Fengli Qu, Xiaobing Zhang, Weihong Tan
Nontoxic prodrugs, especially activated by tumor microenvironment, are urgently required for reducing the side effects of cancer therapy. And combination of chemo-photodynamic therapy prodrugs show effectively synergetic therapeutic efficiency, however,...
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- Chromium complexes for luminescence, solar cells, photoredox catalysis,
upconversion, and phototriggered NO release
Abstract:Chem. Sci. , 2017, Advance Article
DOI : 10.1039/C7SC03372A, Perspective Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Laura A. Buldt, Oliver S. Wenger
Cr( III ) and Cr(0) complexes are earth-abundant alternatives to photosensitizers that are commonly made from precious metals.
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- Determination of protonation states of iminosugar-enzyme complexes using
photoinduced electron transfer
Abstract:Chem. Sci. , 2017, Advance Article
DOI : 10.1039/C7SC01540B, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Bo Wang, Jacob Ingemar Olsen, Bo W. Laursen, Jens Christian Navarro Poulsen, Mikael Bols
N -alkylated analogues of 1-deoxynojirimycin inhibit [small beta]-glucosidase from white rot fungus. The amino group in the [small beta]-glucosidase-iminosugar complex is unprotonated when bound, while an active site carboxylate is protonated.
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- Multi-dimensional charge transport in supramolecular helical foldamer
assemblies
Abstract:Chem. Sci. , 2017, Advance Article
DOI : 10.1039/C7SC03341A, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Alejandro Mendez-Ardoy, Nagula Markandeya, Xuesong Li, Yu-Tang Tsai, Gilles Pecastaings, Thierry Buffeteau, Victor Maurizot, Luca Muccioli, Frederic Castet, Ivan Huc, Dario M. Bassani
Helical aromatic foldamers are bioinspired architectures that combine through-bond and through-space charge transport in a single molecule.
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- Achieving Enhanced Cell Penetration of Short Conformationally Constrained
Peptides through Amphiphilicity Tuning
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC03614K, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Yuan Tian, Xiangze Zeng, Jingxu Li, Yanhong Jiang, Hui Zhao, Dongyuan Wang, Xuhui Huang, Zigang Li
Due to their enhanced stability and cell permeablity, cyclic cell penetrating peptides have been widely used as delivery vectors for transporting cell-impermeable cargos into cells. In this study, we synthesized...
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- Selective inhibition of cancer cells by enzyme-induced gain of function of
phosphorylated melittin analogues
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC03217J, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Qian-Qian Li, Puguang Chen, Zhi-Wen Hu, Yuan Cao, Liang-Xiao Chen, Yong-Xiang Chen, Yu-Fen Zhao, Yanmei Li
The selective killing of cancer cells and the avoidance of drug resistance are still difficult challenges in cancer therapy. Here, we report a new strategy that uses enzyme-induced gain of...
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- Crystalline Boron-linked Tetraaminoethylene Radical Cations
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC03528D, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Yuanting Su, Yongxin Li, Rakesh Ganguly, Rei Kinjo
Single-electron oxidation of neutral boryl-linked tetraaminoethylene derivatives (4) led to the formation of radical cations (4[round bullet, filled]+), which have been isolated and fully characterized. X-ray diffraction analysis, EPR spectroscopy, and computational...
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- New Face of Phenalenyl Based Radical in Transition Metal Free C-H
Arylation of Heteroarenes at Room Temperature: Trapping the Radical
Initiator via C-C [sigma] Bond Formation
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC02661G, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Swadhin K Mandal, Jasimuddin Ahmed, Sreejyothi P, Gonela Vijaykumar, Anex Jose, Manthan Raj
Radical mediated transition metal free approach for direct C-H bond functionalization of arenes is considered as a cost effective alternative to the transition metal based catalysis. An organic ligand based...
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- Laboratory-scale photoredox catalysis using hydrated electrons sustainably
generated with a single green laser
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC03514D, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Robert Naumann, Christoph Kerzig, Martin Goez
The ruthenium-tris-bipyridyl dication as catalyst combined with the ascorbate dianion as bioavailable sacrificial donor provides the first regenerative source of hydrated electrons for chemical syntheses on millimolar scales. This electron...
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- Spatially-resolved soft materials for controlled release - hybrid
hydrogels combining a robust photo-activated polymer gel with an
interactive supramolecular gel
Abstract:Chem. Sci. , 2017, Advance Article
DOI : 10.1039/C7SC02210G, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Phillip R. A. Chivers, David K. Smith
Self-supporting photo-patterned hybrid gels achieve controlled directional release depending on their surrounding environment.
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- Tertiary Amine Synthesis via Reductive Coupling of Amides with Grignard
Reagents
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC03613B, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Darren Dixon, Lan-Gui Xie
A new iridium catalyzed reductive coupling reaction of Grignard reagents and tertiary amides affording functionalised tertiary amine products via an efficient and technically-simple one-pot, two-stage experimental protocol, is reported. The...
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- Michael addition-based probes for ratiometric fluorescence imaging of
protein S-depalmitoylases in live cells and tissues
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC02805A, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Michael Beck, Rahul Kathayat, Candace Cham, Eugene Chang, Bryan Dickinson
The reversible modification of cysteine residues through thioester formation with palmitate (protein S-palmitoylation) is a prevalent chemical modification that regulates the function, localization, and stability of many proteins. Current methods...
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- Hyperfine Adjustment of Flexible Pore-Surface Pockets Enables Smart
Recognitions of Gas Size and Quadrupole Moment
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC03067C, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Chun-Ting He, Zi-Ming Ye, Yantong Xu, Dong-Dong Zhou, Hao-Long Zhou, Da Chen, Jie-Peng Zhang, Xiao-Ming Chen
Pore size and framework flexibility of hosts are of vital importance for molecular recognitions and related applications, but accurate control of these parameters is very challenging. We use the slight...
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- The Photochemical Alkylation and Reduction of Heteroarenes
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC03768F, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Louis Barriault, Juan Tito Scaiano, Terry McCallum, Spencer Paul Pitre, Mathieu Morin
The functionalization of heteroarenes has been integral to the structural diversification of medicinally active molecules such as quinolines, pyridines, and phenanthridines. Electron-deficient heteroarenes are electronically compatible to react with relatively...
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- Efficient and Stable Single-Doped White OLEDs Using a Palladium-Based
Phosphorescent Excimer
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC02512B, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Tyler Fleetham, Yunlong Ji, Liang Huang, Trenten S Fleetham, Jian Li
A tetradentate Pd(II) complex, Pd3O3, which exhibits highly efficient excimer emission is synthesized and characterized. Pd3O3 can achieve blue emission despite using phenyl-pyridine emissive ligands which have been a mainstay...
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- Molecular and Cellular Mechanisms of HIF Prolyl Hydroxylase inhibitors in
Clinical Trials
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC02103H, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Tzu-Lan Yeh, Thomas M. Leissing, Martine I. Abboud, Cyrille C. Thinnes, Onur Atasoylu, James P. Holt-Martyn, Dong Zhang, Anthony Tumber, Kerstin Lippl, Christopher T Lohans, Ivanhoe K. H. Leung, Helen Morcrette, Akane Kawamura, Emily Flashman, Xin Lu, Peter J. Ratcliffe, Rasheduzzaman Chowdhury, Christopher W Pugh, Christopher J Schofield
Inhibition of the human 2-oxoglutarate (2OG) dependent hypoxia inducible factor (HIF) prolyl hydroxylases (human PHD1-3) causes upregulation of HIF, thus promoting erythropoiesis and is therefore of therapeutic interest. We describe...
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- Cholesterol-Directed Nanoparticle Assemblies Based on Single Amino Acid
Peptide Mutations Activate Cellular Uptake and Decrease Tumor Volume
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC02616A, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. shang Li, Rongfeng Zou, Yaoquan Tu, Junchen Wu, Markita Landry
Peptide drugs have been difficult to translate into effective therapies due to their low in vivo stability. Here, we report a strategy to develop peptide-based therapeutic nanoparticles by screening a...
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- Formylation or methylation: what determine the chemoselectivity of
reactions of amine, CO2, and hydrosilane, catalyzed by
1,3,2-diazaphospholene'
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC00824D, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Yu Lu, Zhong-hua Gao, Xiang-Yu Chen, Jiandong Guo, Zheyuan Liu, Yanfeng Dang, Song Ye, Zhi-Xiang Wang
DFT computations have been performed to gain insight into the mechanisms of formylation/methylation of amines (e.g. methylaniline(1a)/2,2,4,4,-tetramethylpiperidine (2a)) with CO2 and hydrosilane ([Si]H2, [Si]=Ph2Si), catalyzed by 1,3,2-diazaphospholene ([NHP]H). Different from...
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- Preferential targeting of I-motifs and G-quadruplexes by small molecules
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC02693E, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Manish Debnath, Shirsendu Ghosh, Ajay Chauhan, Rakesh Paul, Kankan Bhattacharyya, Jyotirmayee Dash
I-motifs and G-quadruplexes are dynamic nucleic acid secondary structures, which are believed to play key roles in gene expression. We herein report two peptidomimetic ligands (PBP1 and PBP2) that selectively...
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- Protonation Tuning of Quantum Interference in Azulene-Type Single-Molecule
Junctions
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC01014A, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Guogang Yang, Sara Sangtarash, Zitong Liu, Xiaohui Li, Hatef Sadeghi, Zhibing Tan, Ruihao Li, Jueting Zheng, Xiaobiao Dong, Jun-Yang Liu, Yang Yang, Jia Shi, Zongyuan Xiao, Guanxin Zhang, Colin Lambert, wenjing hong, Deqing Zhang
The protonation of azulene derivatives with quantum interference effect is studied by the conductance measurements of single-molecule junctions. Three azulene derivatives with different connectivities are synthesized and reacted with trifluoroacetic...
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- Comparisons of Lanthanide / Actinide +2 Ions in a Tris(aryloxide)arene
Coordination Environment
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC02337E, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Megan E Fieser, Chad T Palumbo, Henry Storms La Pierre, Dominik P. Halter, Vamsee K Voora, Joseph W Ziller, Filipp Furche, Karsten Meyer, William J Evans
A new series of Ln 3+ and Ln 2+ complexes has been synthesized using the tris(aryloxide)arene ligand system, (( Ad,Me ArO)3mes) 3- , recently used to isolate a complex of U 2+ . The triphenol precursor, ( Ad,Me ArOH) 3 mes, reacts...
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- Manganese Complex-Catalyzed Oxidation and Oxidative Kinetic Resolution of
Secondary Alcohols by Hydrogen Peroxide
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC00891K, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Cheng-Xia Miao, Xiao-Xi Li, Yong-Min Lee, Chungu Xia, Yong Wang, Wonwoo Nam, Wei Sun
A highly efficient catalytic oxidation and oxidative kinetic resolution (OKR) of secondary alcohols has been achieved using a synthetic manganese catalyst with a low loading and hydrogen peroxide as an...
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- Gelation-driven selection in dynamic covalent C[double bond, length as
m-dash]C/C[double bond, length as m-dash]N exchange
Abstract:Chem. Sci. , 2017, Advance Article
DOI : 10.1039/C7SC02827J, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Chunshuang Liang, Sirinan Kulchat, Shimei Jiang, Jean-Marie Lehn
Gelation-driven amplification of an optimal gel-forming constituent is demonstrated for dynamic covalent libraries based on C[double bond, length as m-dash]C/C[double bond, length as m-dash]N exchange, through selection of the components leading to the most stable gel.
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- Self-quenched Ferrocenyl Diketopyrrolopyrrole Organic Nanoparticles with
Amplifying Photothermal Effect for Cancer Therapy
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC03351F, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Xiao-Chen Dong, Pingping Liang, Qianyun Tang, Yu Cai, Gongyuan Liu, Weili Si, JINJUN SHAO, Wei Huang, Qi Zhang
Organic nanoparticles (NPs) with near-infrared absorbance possess high photothermal conversion (PTC) efficiency and excellent photoacoustic signal, presenting a great prospect for photoacoustic imaging (PAI) guided photothermal therapy (PTT). Herein, a...
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- Theoretical Predictions Suggest Carbon Dioxide Phases III and VII are
Identical
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC03267F, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Watit Sontising, Yonaton N Heit, Jessica L McKinley, Gregory J O Beran
Solid carbon dioxide exhibits a rich phase diagram at high pressures. Metastable phase III is formed by compressing dry ice above [similar]10-12 GPa. Phase VII occurs at similar pressures but...
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- Violations of Lowenstein's rule in zeolites
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC02531A, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Rachel E Fletcher, Sanliang Ling, Ben Slater
Zeolites, microporous aluminosilicates, are amongst the most widely used catalysts in the petrochemical industry. Zeolite catalytic functionality is influenced by the location of tetrahedral alumina (AlO4-) and associated counter-cations in...
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- Protein labeling for live cell fluorescence microscopy with a highly
photostable renewable signal
Abstract:Chem. Sci. , 2017, Advance Article
DOI : 10.1039/C7SC01628J, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Nina G. Bozhanova, Mikhail S. Baranov, Natalia V. Klementieva, Karen S. Sarkisyan, Alexey S. Gavrikov, Ilia V. Yampolsky, Elena V. Zagaynova, Sergey A. Lukyanov, Konstantin A. Lukyanov, Alexander S. Mishin
A novel method of protein labeling uses the highly dynamic reversible association of a cell-permeable fluorogenic dye and lipocalin Blc mutants.
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- Fluorogenic Labeling and Single-Base Resolution Analysis of
5-Formylcytosine in DNA
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC03685J, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Xiang Zhou, Chaoxin Liu, Yafen Wang, Wei Yang, Fan Wu, Weiwu Zeng, Zonggui Chen, Jinguo Huang, Guangrong Zhou, Xiong Zhang, Shaoru Wang, Xiaocheng Weng, Zhiguo Wu, Yu Zhou
5-Formylcytosine (5fC), which plays an important role in epigenetic functions, has received widespread attention in many related fields. Here, we demonstrated a new design for both fluorogenic switch-on detection and...
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- A Unified Photoredox-Catalysis Strategy for C(sp3)-H Hydroxylation and
Amidation Using Hypervalent Iodine
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC02773G, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Guo-Xing Li, Cristian A. Morales-Rivera, Fang Gao, Yaxin Wang, Gang He, Peng Liu, Gong Chen
We report a unified photoredox-catalysis strategy for both hydroxylation and amidation of tertiary and benzylic C-H bonds. Use of hydroxyl perfluorobenziodoxole (PFBl-OH) oxidant is critical for efficient tertiary C-H functionalization,...
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- Synthesis of azasilacyclopentenes and silanols via Huisgen
cycloaddition-initiated C-H bond insertion cascades
Abstract:Chem. Sci. , 2017, Advance Article
DOI : 10.1039/C7SC03130K, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Jiun-Le Shih, Santa Jansone-Popova, Christopher Huynh, Jeremy A. May
Alkynyl carbonazidates form azasilacyclopentenes via a series of cyclizations, rearrangements, and an [small alpha]-sily1 C-H bond insertion as determined by mechanistic investigations.
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- Uncaging Carbon Disulfide. Delivery Platforms for Potential
Pharmacological Applications: A Mechanistic Approach.
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC02727C, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Anthony W DeMartino, Maykon Lima Souza, Peter C Ford
We describe the kinetics of the formation and decay of a series of dithiocarbamates under physiological conditions. The goal is to provide a toolbox of compounds that release CS2 by...
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- Highly Photostable Wide-Dynamic-Range pH Sensitive Semiconducting Polymer
Dot Enabled by Dendronizing the Near-IR Emitters
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC03448B, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Lei Chen, li wu, Jiangbo Yu, Chun-Ting Kuo, Teng-yue Jian, I-che Wu, Yu Rong, Daniel T Chiu
One constraint of semiconducting polymer dots (Pdots), especially those with near-IR emission, is their low effective emitter ratio (~ 1.5 mole percent), which limits their pH sensing performance. The other...
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- Design, crystal structure and atomic force microscopy study of thioether
ligated D,L-cyclic antimicrobial peptides against multidrug resistant
Pseudomonas aeruginosa
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC01599B, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Runze He, Ivan Dibonaventura, Ricardo Visini, Bee-Ha Gan, Yongchun Fu, Daniel Probst, Alexandre Luscher, Thilo Kohler, Christian van Delden, Achim Stocker, Wenjing Hong, Tamis Darbre, Jean-Louis Reymond
Here we report a new family of cyclic antimicrobial peptides (CAMPs) targeting MDR strains of Pseudomonas aeruginosa. These CAMPs are cyclized via a xylene double thioether bridge connecting two cysteines...
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- Selective Photocatalytic Hydroxylation and Epoxidation Reaction by an Iron
Complex Using Water as the Oxygen Source
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC02780J, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Bittu Chandra, Kundan K Singh, Sayam Sen Gupta
The iron complex, [(bTAML)FeIII-OH2]-(1), selectively catalyses the photocatalytic hydroxylation and epoxidation reactions of alkanes and alkenes respectively using water as the oxygen-atom source. Upon oxidation of unactivated alkanes, which included...
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- Design of an enantioselective artificial metallo-hydratase enzyme
containing an unnatural metal-binding amino acid
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC03477F, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Ivana Drienovska, Lur Alonso Cotchico, Pietro Vidossich, Agustin Lledos, Jean-Didier Marechal, Gerard Roelfes
The design of artificial metalloenzymes is a challenging, yet ultimately highly rewarding objective because of the potential for accessing new-to-nature reactions. One of the main challenges is identifying catalytically active...
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- Photosensitizer-free visible light-mediated gold-catalysed
cis-difunctionalization of silyl-substituted alkynes
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC02294H, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Man Kin Wong, Jie-Ren Deng, Wing-Cheung Chan, Nathanael Chun-Him Lai, Bin Yang, Chui-Shan Tsang, Ben, Chi-Bun Ko, Sharon Lai-Fung Chan
A new photosensitizer-free visible light-mediated gold-catalysed cis-difunctionalization reaction is developed. The reaction was chemoselective towards silyl-substituted alkynes with excellent regioselectivity and good functional group compatibility, giving a series of silyl-substituted...
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- Combining the catalytic enantioselective reaction of
visible-light-generated radicals with a by-product utilization system
Abstract:Chem. Sci. , 2017, Advance Article
DOI : 10.1039/C7SC02621H, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Xiaoqiang Huang, Shipeng Luo, Olaf Burghaus, Richard D. Webster, Klaus Harms, Eric Meggers
We report an unusual reaction design in which a chiral bis-cyclometalated rhodium( III ) complex enables the stereocontrolled chemistry of photo-generated carbon-centered radicals and at the same time catalyzes an enantioselective sulfonyl radical addition to an alkene.
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- Catalyst-controlled polycondensation of glycerol with diacyl chlorides:
linear polyesters from a trifunctional monomer
Abstract:Chem. Sci. , 2017, Advance Article
DOI : 10.1039/C7SC01886J, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Ekaterina Slavko, Mark S. Taylor
Selective activation of diol groups by a borinic acid catalyst enables the synthesis of strictly linear polyesters from glycerol, a trifunctional monomer.
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2,5-bis(4-alkoxycarbonylphenyl)-1,4-diaryl-1,4-dihydropyrrolo[3,2-b]pyrrole
(AAPP) AIEgens: tunable RIR and TICT characteristics and their
multifunctional applications
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC03076B, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Kai Li, Yuanyuan Liu, Yuanyuan Li, Qi Feng, Hongwei Hou, Ben Zhong Tang
Aggregation-induced emission luminogens (AIEgens) have attracted extensive interest for their outstanding luminescent properties in aggregated state and even in solid state. In this work, we developed a series of novel...
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- Scaling behaviour and rate-determining steps in filamentous self-assembly
Abstract:Chem. Sci. , 2017, Advance Article
DOI : 10.1039/C7SC01965C, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Georg Meisl, Luke Rajah, Samuel A. I. Cohen, Manuela Pfammatter, Andela Saric, Erik Hellstrand, Alexander K. Buell, Adriano Aguzzi, Sara Linse, Michele Vendruscolo, Christopher M. Dobson, Tuomas P. J. Knowles
A general reaction network for filamentous self-assembly unifies mechanistic descriptions and links the overall scaling behaviour to the underlying rate-determining steps.
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- Reversible control of cell membrane receptor function using DNA
nano-spring multivalent ligands
Abstract:Chem. Sci. , 2017, Advance Article
DOI : 10.1039/C7SC02489D, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Kaixiang Zhang, Ruijie Deng, Yupeng Sun, Ling Zhang, Jinghong Li
DNA nano-spring multivalent ligands for reversibly controlling the nanoscale distribution of cell binding ligands and regulating the cell behavior.
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- Effects of Electron Transfer on the Stability of Hydrogen Bonds
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC03361C, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Tyler M. Porter, Gavin P, Heim, Clifford P. Kubiak
The measurement of the dimerization constants of hydrogen-bonded ruthenium complexes ( 1 2 , 2 2 , 3 2 ) linked by a self-complementary pair of 4-pyridylcarboxylic acid ligands in different redox states is reported. Using a...
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- Total Synthesis of Schilancidilactones A, B and Schilancitrilactone A,
20-epi-Schilancitrilactone A via Late-stage Nickel-catalyzed cross
coupling
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC03293E, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Hengtao Wang, Xiunan Zhang, pingping tang
The first total synthesis of schilancidilactones A, B and schilancitrilactone A, 20-epi-schilancitrilactone A have been accomplished using a nickel-catalyzed cross coupling of alkyl bromide with vinyl stannane as the final...
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- Optical control of GPR40 signalling in pancreatic [small beta]-cells
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC01475A, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. James Allen Frank, Dmytro Yushchenko, Nick H. F. Fine, Margherita Duca, Mevlut Citir, Johannes Broichhagen, David J Hodson, Carsten Schultz, Dirk Trauner
Fatty acids activate GPR40 and K+ channels to modulate beta-cell function. Herein, we describe the design and synthesis of FAAzo-10, a light-controllable GPR40 agonist based on Gw-9508. FAAzo-10 is a...
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- Highly selective acylation of polyamines and aminoglycosides by
5-acyl-5-phenyl-1,5-dihydro-4H-pyrazol-4-ones
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC03184J, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Kostiantyn O. Marichev, Estevan C. Garcia, KARTICK CHANDRA BHOWMICK, Daniel J. Wherritt, Hadi Arman, Michael P Doyle
5-Acyl-5-phenyl-1,5-dihydro-4H-pyrazol-4-ones, accessible from arylpropargyl phenyldiazoacetates, are highly selective acyl transfer reagents for di- and polyamines, as well as aminoalcohols and aminothiols. As reagents with a carbon-based leaving group, they have...
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- Programmed serial stereochemical relay and its application in the
synthesis of morphinans
Abstract:Chem. Sci. , 2017, Advance Article
DOI : 10.1039/C7SC03189K, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Kun Ho (Kenny) Park, Rui Chen, David Y.-K. Chen
A rationally designed, serial point-to-axial and axial-to-point stereoinduction and its integration into a multi-step and target-oriented organic synthesis was demonstrated in a novel chemical method to access morphinans and it is potentially applicable to other structurally related alkaloids.
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- Copper-catalyzed cyanothiolation to incorporate a sulfur-substituted
quaternary carbon center
Abstract:Chem. Sci. , 2017, Advance Article
DOI : 10.1039/C7SC02867A, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Yubing Huang, Xianwei Li, Xu Wang, Yue Yu, Jia Zheng, Wanqing Wu, Huanfeng Jiang
A copper-catalyzed cyanothiolation of N -tosylhydrazones with thiocyanates to generate [small alpha]-arylthioalkanenitriles bearing sulfur-substituted quaternary carbon center atoms has been achieved.
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- Ratiometric photoacoustic imaging of endoplasmic reticulum polarity in
injured liver tissues of diabetic mice
Abstract:Chem. Sci. , 2017, Advance Article
DOI : 10.1039/C7SC02330H, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Haibin Xiao, Chuanchen Wu, Ping Li, Wen Gao, Wen Zhang, Wei Zhang, Lili Tong, Bo Tang
We have developed a new fluorescent and photoacoustic dual-mode probe, ER-P, for the detection of ER polarity of liver tissues in normal and diabetic mice.
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- Nucleophilic addition and substitution at coordinatively saturated boron
by facile 1,2-hydrogen shuttling onto a carbene donor
Abstract:Chem. Sci. , 2017, Advance Article
DOI : 10.1039/C7SC03193A, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Dominic Auerhammer, Merle Arrowsmith, Holger Braunschweig, Rian D. Dewhurst, J. Oscar C. Jimenez-Halla, Thomas Kupfer
Anionic organic sp 3 -, sp 2 - and sp-nucleophiles as well as neutral Lewis bases were shown to add to a coordinatively saturated cyclic (alkyl)(amino)carbene (cAAC) supported borane thanks to reversible transfer of a hydrogen atom from boron to the adjacent Lewis acidic cAAC carbene carbon atom.
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- Molecular design of upconversion nanoparticles for gene delivery
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC02956J, Minireview Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Wing-Fu Lai, Andrey Rogach, Wing-Tak Wong
Due to their large anti-Stokes shifts, sharp emission spectra and long excited-state lifetimes, upconversion nanoparticles (UCNPs) have attracted an increasing amount of research interest, and have shown great potential for...
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- A novel peptide stapling strategy enables retention of ring-closing amino
acid side chains for Wnt/[small beta]-catenin signalling pathway
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC02420G, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Ye Wu, Yehua Li, Xiang Li, Yan Zou, Hongli Liao, Lei Liu, Yeguang Chen, Donald Bierer, Honggang Hu
All-hydrocarbon peptide stapling strategy has recently been extensively explored in drug discovery. There remains potential improvement regarding the retention of the amino acid side chains at the stapled positions. Herein,...
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- Origins of High Catalyst Loading in Copper(I)-Catalysed Ullmann-Goldberg
C-N Coupling Reactions
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC02859H, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Grant J Sherborne, Sven Adomeit, Robert Menzel, Jabor Rabeah, Angelika Bruckner, Mark R Fielding, Charlotte E. Willans, Bao N. Nguyen
Mechanistic investigation of Ullmann-Golberg reactions using soluble and partially soluble bases led to identification of various pathways for catalyst deactivation through (i) product inhibition with amine products, (ii) byproduct inhibition...
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- Simultaneously quantify multiple endogenous biothiols in single living
cells by plasmonic Raman probes
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC03218H, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Shan-Shan Li, Qi-Yuan Guan, Mengmeng Zheng, Yuqi Wang, Deju Ye, Bin Kang, Jing-Juan Xu, Hong-Yuan Chen
Intracellular biothiols mediate many important physiological and pathological progresses. Due to the low content and their competing thiol-reactivity, it is still an unmet challenge to quantify them within complicated intracellular...
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- Pressure-Induced Dramatic Changes in Organic-Inorganic Halide Perovskites
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC01845B, Perspective Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Xujie Lu, Wenge Yang, Quanxi Jia, Hongwu Xu
Organic-inorganic halide perovskites have emerged as a promising family of functional materials for advanced photovoltaic and optoelectronic applications with high performance and low costs. Various chemical methods and processing approaches...
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- All-Metal Aromatic Cationic Palladium Triangles Can Mimic Aromatic Donor
Ligands towards Lewis Acidic Cations
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC03475J, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Giovanni Maestri, Yanlan WANG, Anna Monfredini, Pierre-Alexandre Deyris, Etienne Derat, Max Malacria, Florent Blanchard
We present that cationic rings could act as donor ligands thanks to suitably delocalized metal-metal bonds. This could grant to parent complexes the peculiar properties of aromatic rings crafted with...
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- Fluorescent Turn-on Probes for Wash-Free mRNA Imaging via Covalent
Site-Specific Enzymatic Labeling
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC03150E, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Cun Yu Zhou, Seth C Alexander, Neal Devaraj
Investigating the many roles RNA plays in cellular regulation and function has increased demand for tools to explore RNA tracking and localization within cells. Our recently reported RNA-TAG (transglycosylation at...
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- Trapping intermediate MLCT states in low-symmetry {Ru(bpy)} complexes
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC02670F, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Alejandro Cadranel, Paola Oviedo, German Eduardo Pieslinger, Shiori Yamazak, Valeria D Kleiman, Luis Mario Baraldo, Dirk M. Guldi
Picosecond excited state dynamics of [Ru(tpm)(bpy)(NCS)]+ (RubNCS+) and [Ru(tpm)(bpy)(CN)]+ (RubCN+) (tpm = tris(1-pyrazolyl)methane, bpy = 2,2'-bipyridine) have been analyzed by means of transient absorption measurements and spectroelectrochemistry. Emissive 3MLCTs with...
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- Identification of new quorum sensing autoinducer binding partners in
Pseudomonas aeruginosa using photoaffinity probes
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC01270E, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Ysobel R Baker, James T Hodgkinson, Bobby I Florea, Esther Alza, Warren Galloway, Larson Grimes, Stephen Michael Geddis, Stephen Walsh, Herman S. Overkleeft, Martin Welch, David R Spring
Many bacterial species, including the human pathogen Pseudomonas aeruginosa , employ a mechanism of intercellular communication known as quorum sensing (QS), which is mediated by signalling molecules termed autoinducers. The Pseudomonas...
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- Multifunctional (3-in-1) cancer theranostics applications of
hydroxyquinoline appended polyfluorene nanoparticles
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC03321D, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Sayan Roy Chowdhury, Sudip Mukherjee, Sourav Das, Chittaranjan Patra, Parameswar K Iyer
The accumulation of fluorescent hydroxyquinoline affixed polyfluorene (PF-HQ) nanoparticles and their utility for multi-color bio-imaging and drug delivery for cancer treatment is reported. The formation of nanoparticles (PF-HQ) containing hydrophobic...
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- Enantioselective Nazarov cyclization of indole enones cooperatively
catalyzed by Lewis acids and chiral Bronsted acids
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC03183A, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Guo-Peng Wang, Meng-Qing Chen, Shou-Fei Zhu, Qi-Lin Zhou
Enantioselective control of the chirality of the tertiary [small alpha]-carbon in the products of Nazarov cyclization of enones is challenging because the reaction involves an enantioselective proton transfer process. We herein...
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- Defining the current scope and limitations of dual noncanonical amino acid
mutagenesis in mammalian cells
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC02560B, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Yunan Zheng, Partha Sarathi Addy, Raja Mukherjee, Abhishek Chatterjee
The ability to site-specifically incorporate two distinct noncanonical amino acids (ncAAs) into the proteome of a mammalian cell with high fidelity and efficiency will have many enabling applications. It would...
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- A red-emissive antibody-AIEgen conjugate for turn-on and wash-free imaging
of specific cancer cells
Abstract:Chem. Sci. , 2017, Advance Article
DOI : 10.1039/C7SC01054K, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Xiujuan Shi, Chris Y. Y. Yu, Huifang Su, Ryan T. K. Kwok, Meijuan Jiang, Zikai He, Jacky W. Y. Lam, Ben Zhong Tang
For the first time, an AIEgen-conjugated monoclonal antibody is designed for "turn-on" and "wash-free" imaging of EGFR-overexpressed cancer cells.
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- Mechanistic analysis of a copper-catalyzed C-H oxidative cyclization of
carboxylic acids
Abstract:Chem. Sci. , 2017, Advance Article
DOI : 10.1039/C7SC02240A, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Shibdas Banerjee, Shyam Sathyamoorthi, J. Du Bois, Richard N. Zare
Experimental evidence supports a mechanism for oxidative conversion of carboxylic acids to lactones that initiates with C-H abstraction by sulfate radical anion. The reaction is found to proceed through a carbocationic intermediate with redox cycling of copper ion.
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- Room temperature C(sp2)-H oxidative chlorination via photoredox catalysis
Abstract:Chem. Sci. , 2017, Advance Article
DOI : 10.1039/C7SC03010J, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Lei Zhang, Xile Hu
Photoredox catalysis has been developed to achieve room temperature oxidative C-H chlorination of aromatic compounds using NaCl as the chlorine source and Na 2 S 2 O 8 as the oxidant.
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- Pd-catalyzed asymmetric allylic alkylations via C-H activation of N-allyl
imines with glycinates
Abstract:Chem. Sci. , 2017, Advance Article
DOI : 10.1039/C7SC02899G, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Barry M. Trost, Xiaoxun Li
Facile access to versatile [small alpha],[small beta]-diamine esters derives from an unprecedented C-H activation to generate aza-[small pi]-allyl palladium intermediates asymmetrically.
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- Dearomatization of Electron Poor Six-Membered N-Heterocycles through [3+2]
Annulation with Aminocyclopropanes
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC03197A, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Johannes Preindl, Shyamal Chakrabarty, Jerome Waser
Many abundant and highly bioactive natural alkaloids contain an indolizidine skeleton. A simple, high yielding method to synthesize this scaffold from N-heterocycles was developed. A wide range of pyridines, quinolines...
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- [small beta]-Carbon Elimination Strategy as Convenient in situ Access to
Cyclopentadienyl Metal Complexes
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC02986A, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Gints Smits, Benoit Audic, Matthew D. Wodrich, Clemence Corminboeuf, Nicolai Cramer
The electronic and steric properties of tailored Cyclopentadienyl (Cp) ligands are a powerful handle to modulate their catalytic properties of their metal complexes. This requires the individual preparation, purification and...
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- Atomistic simulations of graphite etching at realistic time scales
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC02763J, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Damien Aussems, Kristof M. Bal, Thomas W. Morgan, Mauritius C.M. van de Sanden, Erik C. Neyts
Hydrogen-graphite interactions are relevant to a wide variety of applications, ranging from astrophysics to fusion devices and nano-electronics. In order to shed light on these interactions, atomistic simulation by Molecular...
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- Thiophene bridged aldehydes (TBAs) image ALDH activity in cells via
modulation of intramolecular charge transfer
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC03017G, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Niren Murthy, Santanu Maity, Corinne Marie Sadlowski, Jung Ming G Lin, Che-Hong Chen, Eun-Soo Lee, Giri K Vegesna, Charles Lee, Daria Mochly-Rosen, Sanjay Kumar, Se-Hwa Kim, Li-Hua Peng
Aldehyde dehydrogenases (ALDHs) catalyze the oxidation of an aldehyde to a carboxylic acid and are implicated in the etiology of numerous diseases. However, despite their importance, imaging ALDH activity in...
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- A Complementary Pair of Enantioselective Switchable Organocatalysts
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC02462B, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Guillaume De Bo, David Leigh, Charlie Thomas McTernan, Shoufeng Wang
A pair of enantioselective switchable bifunctional catalysts are shown to promote a range of conjugate addition reactions in up to 95:5 e.r. and 95 % conversion. Each catalyst can be...
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- Immuno-Targeting of Staphylococcus aureus via Surface Remodeling Complexes
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC02721D, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Mary J Sabulski, Sean Pidgeon, Marcos Moura Pires
Agents with novel mechanisms of action are needed to complement traditional antibiotics. Towards these goals, we have exploited the surface-homing properties of vancomycin to tag the surface of Gram-positive pathogens...
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- Catalysis of a 1,3-dipolar reaction by distorted DNA incorporating a
heterobimetallic platinum (II) and copper (II) complex
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC02311A, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Ivan Rivilla de la Cruz, Abel de Cozar, Thomas Schafer, Frank J Hernandez, Alexander M Bittner, Aitziber Eleta, Ali Aboudzadeh, JOSE IGNACIO SANTOS, Jose Ignacio Miranda, Fernando Cossio
A novel catalytic system based on covalently modified DNA is described. This catalyst promotes 1,3-dipolar reactions between azomethine ylides and maleimides. The catalytic system is based on the distortion of...
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- What is the fundamental ion-specific series for anions and cations'
Ion specificity in standard partial molar volumes of electrolytes and
electrostriction in water and non-aqueous solvents
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC02691A, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Virginia Mazzini, Vincent S. J. Craig
The importance of electrolyte solutions cannot be overstated. Beyond the ionic strength of electrolyte solutions the specific nature of the ions present is vital in controlling a host of properties....
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- Fluorinated molecular beacons as functional DNA nanomolecules for cellular
imaging
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC02819A, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Cheng Jin, Ting Fu, Ruowen Wang, Hui Liu, Jiamei Zou, Zilong Zhao, Mao Ye, Xiaobing Zhang, Weihong Tan
Molecular beacons (MBs) are simple, but practical, fluorescent nanoprobes widely used to detect small molecules, nucleic acids and proteins. However, some challenges still remain when MBs are employed in complex...
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- Photocatalytic oxidation of benzene to phenol using dioxygen as an oxygen
source and water as an electron source in the presence of a cobalt
catalyst
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC02495A, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Ji Won Han, Jieun Jung, Yong-Min Lee, Wonwoo Nam, Shunichi Fukuzumi
Photocatalytic hydroxylation of benzene to phenol by dioxygen (O 2 ) occurs under visible light irradiation of an O 2 -saturated acetonitrile solution containing [Ru II (Me 2 phen) 3 ] 2+ as a photocatalyst, [Co III (Cp*)(bpy)(H 2 O)] 2+ as an efficient catalyst for...
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- Nano/micro-vehicles for efficient delivery and (bio)sensing at cellular
level
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC02434G, Perspective Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Susana Campuzano, Berta Esteban-Fernandez de Avila, Paloma Yanez-Sedeno, Jose M Pingarron, Joseph Wang
A perspective review of recent strategies involving the use of nano/micro-vehicles to address key challenges associated with delivery and (bio)sensing at the cellular level is presented. The main types and...
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- A Platform for High-Throughput Screening of DNA-Encoded Catalyst Libraries
in Organic Solvents
Abstract: Chem. Sci. , 2017, Accepted Manuscript
DOI : 10.1039/C7SC02779F, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Katherine Delaney Hook, John T Chambers, Ryan Hili
We have developed a novel high-throughput screening platform for the discovery of small-molecules catalysts for bond-forming reactions. The method employs an in vitro selection for bond-formation using amphiphilic DNA-encoded small...
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