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  Subjects -> CHEMISTRY (Total: 891 journals)
    - ANALYTICAL CHEMISTRY (55 journals)
    - CHEMISTRY (621 journals)
    - CRYSTALLOGRAPHY (21 journals)
    - ELECTROCHEMISTRY (28 journals)
    - INORGANIC CHEMISTRY (45 journals)
    - ORGANIC CHEMISTRY (51 journals)
    - PHYSICAL CHEMISTRY (70 journals)

CHEMISTRY (621 journals)                  1 2 3 4 | Last

Showing 1 - 200 of 735 Journals sorted alphabetically
2D Materials     Hybrid Journal   (Followers: 14)
Accreditation and Quality Assurance: Journal for Quality, Comparability and Reliability in Chemical Measurement     Hybrid Journal   (Followers: 26)
ACS Catalysis     Full-text available via subscription   (Followers: 43)
ACS Chemical Neuroscience     Full-text available via subscription   (Followers: 21)
ACS Combinatorial Science     Full-text available via subscription   (Followers: 23)
ACS Macro Letters     Full-text available via subscription   (Followers: 26)
ACS Medicinal Chemistry Letters     Full-text available via subscription   (Followers: 41)
ACS Nano     Full-text available via subscription   (Followers: 273)
ACS Photonics     Full-text available via subscription   (Followers: 14)
ACS Symposium Series     Full-text available via subscription  
ACS Synthetic Biology     Full-text available via subscription   (Followers: 24)
Acta Chemica Iasi     Open Access   (Followers: 5)
Acta Chimica Slovaca     Open Access   (Followers: 2)
Acta Chimica Slovenica     Open Access   (Followers: 1)
Acta Chromatographica     Full-text available via subscription   (Followers: 9)
Acta Facultatis Medicae Naissensis     Open Access  
Acta Metallurgica Sinica (English Letters)     Hybrid Journal   (Followers: 7)
Acta Scientifica Naturalis     Open Access   (Followers: 3)
adhäsion KLEBEN & DICHTEN     Hybrid Journal   (Followers: 6)
Adhesion Adhesives & Sealants     Hybrid Journal   (Followers: 9)
Adsorption Science & Technology     Full-text available via subscription   (Followers: 6)
Advanced Functional Materials     Hybrid Journal   (Followers: 57)
Advanced Science Focus     Free   (Followers: 5)
Advances in Chemical Engineering and Science     Open Access   (Followers: 66)
Advances in Chemical Science     Open Access   (Followers: 18)
Advances in Chemistry     Open Access   (Followers: 21)
Advances in Colloid and Interface Science     Full-text available via subscription   (Followers: 19)
Advances in Drug Research     Full-text available via subscription   (Followers: 23)
Advances in Environmental Chemistry     Open Access   (Followers: 5)
Advances in Enzyme Research     Open Access   (Followers: 10)
Advances in Fluorine Science     Full-text available via subscription   (Followers: 9)
Advances in Fuel Cells     Full-text available via subscription   (Followers: 17)
Advances in Heterocyclic Chemistry     Full-text available via subscription   (Followers: 11)
Advances in Materials Physics and Chemistry     Open Access   (Followers: 25)
Advances in Nanoparticles     Open Access   (Followers: 15)
Advances in Organometallic Chemistry     Full-text available via subscription   (Followers: 16)
Advances in Polymer Science     Hybrid Journal   (Followers: 43)
Advances in Protein Chemistry     Full-text available via subscription   (Followers: 18)
Advances in Protein Chemistry and Structural Biology     Full-text available via subscription   (Followers: 19)
Advances in Quantum Chemistry     Full-text available via subscription   (Followers: 6)
Advances in Science and Technology     Full-text available via subscription   (Followers: 12)
African Journal of Bacteriology Research     Open Access  
African Journal of Chemical Education     Open Access   (Followers: 3)
African Journal of Pure and Applied Chemistry     Open Access   (Followers: 7)
Agrokémia és Talajtan     Full-text available via subscription   (Followers: 2)
Al-Kimia : Jurnal Penelitian Sains Kimia     Open Access  
Alkaloids: Chemical and Biological Perspectives     Full-text available via subscription   (Followers: 2)
AMB Express     Open Access   (Followers: 1)
Ambix     Hybrid Journal   (Followers: 3)
American Journal of Biochemistry and Biotechnology     Open Access   (Followers: 64)
American Journal of Biochemistry and Molecular Biology     Open Access   (Followers: 17)
American Journal of Chemistry     Open Access   (Followers: 30)
American Journal of Plant Physiology     Open Access   (Followers: 11)
American Mineralogist     Hybrid Journal   (Followers: 15)
Analyst     Full-text available via subscription   (Followers: 38)
Angewandte Chemie     Hybrid Journal   (Followers: 165)
Angewandte Chemie International Edition     Hybrid Journal   (Followers: 243)
Annales UMCS, Chemia     Open Access  
Annals of Clinical Chemistry and Laboratory Medicine     Open Access   (Followers: 5)
Annual Reports in Computational Chemistry     Full-text available via subscription   (Followers: 3)
Annual Reports Section A (Inorganic Chemistry)     Full-text available via subscription   (Followers: 4)
Annual Reports Section B (Organic Chemistry)     Full-text available via subscription   (Followers: 9)
Annual Review of Chemical and Biomolecular Engineering     Full-text available via subscription   (Followers: 12)
Annual Review of Food Science and Technology     Full-text available via subscription   (Followers: 13)
Anti-Infective Agents     Hybrid Journal   (Followers: 3)
Antiviral Chemistry and Chemotherapy     Hybrid Journal   (Followers: 2)
Applied Organometallic Chemistry     Hybrid Journal   (Followers: 9)
Applied Spectroscopy     Full-text available via subscription   (Followers: 23)
Applied Surface Science     Hybrid Journal   (Followers: 31)
Arabian Journal of Chemistry     Open Access   (Followers: 6)
ARKIVOC     Open Access   (Followers: 1)
Asian Journal of Biochemistry     Open Access   (Followers: 2)
Atomization and Sprays     Full-text available via subscription   (Followers: 4)
Australian Journal of Chemistry     Hybrid Journal   (Followers: 7)
Autophagy     Hybrid Journal   (Followers: 2)
Avances en Quimica     Open Access  
Biochemical Pharmacology     Hybrid Journal   (Followers: 10)
Biochemistry     Full-text available via subscription   (Followers: 348)
Biochemistry Insights     Open Access   (Followers: 6)
Biochemistry Research International     Open Access   (Followers: 6)
BioChip Journal     Hybrid Journal  
Bioinorganic Chemistry and Applications     Open Access   (Followers: 10)
Bioinspired Materials     Open Access   (Followers: 5)
Biointerface Research in Applied Chemistry     Open Access   (Followers: 2)
Biointerphases     Open Access   (Followers: 1)
Biology, Medicine, & Natural Product Chemistry     Open Access   (Followers: 2)
Biomacromolecules     Full-text available via subscription   (Followers: 21)
Biomass Conversion and Biorefinery     Partially Free   (Followers: 10)
Biomedical Chromatography     Hybrid Journal   (Followers: 7)
Biomolecular NMR Assignments     Hybrid Journal   (Followers: 3)
BioNanoScience     Partially Free   (Followers: 5)
Bioorganic & Medicinal Chemistry     Hybrid Journal   (Followers: 130)
Bioorganic & Medicinal Chemistry Letters     Hybrid Journal   (Followers: 84)
Bioorganic Chemistry     Hybrid Journal   (Followers: 10)
Biopolymers     Hybrid Journal   (Followers: 18)
Biosensors     Open Access   (Followers: 2)
Biotechnic and Histochemistry     Hybrid Journal   (Followers: 2)
Bitácora Digital     Open Access  
Boletin de la Sociedad Chilena de Quimica     Open Access  
Bulletin of the Chemical Society of Ethiopia     Open Access   (Followers: 2)
Bulletin of the Chemical Society of Japan     Full-text available via subscription   (Followers: 24)
Bulletin of the Korean Chemical Society     Hybrid Journal   (Followers: 1)
C - Journal of Carbon Research     Open Access   (Followers: 3)
Cakra Kimia (Indonesian E-Journal of Applied Chemistry)     Open Access  
Canadian Association of Radiologists Journal     Full-text available via subscription   (Followers: 2)
Canadian Journal of Chemistry     Hybrid Journal   (Followers: 10)
Canadian Mineralogist     Full-text available via subscription   (Followers: 6)
Carbohydrate Research     Hybrid Journal   (Followers: 26)
Carbon     Hybrid Journal   (Followers: 71)
Catalysis for Sustainable Energy     Open Access   (Followers: 8)
Catalysis Reviews: Science and Engineering     Hybrid Journal   (Followers: 7)
Catalysis Science and Technology     Free   (Followers: 8)
Catalysis Surveys from Asia     Hybrid Journal   (Followers: 3)
Catalysts     Open Access   (Followers: 10)
Cellulose     Hybrid Journal   (Followers: 7)
Cereal Chemistry     Full-text available via subscription   (Followers: 4)
ChemBioEng Reviews     Full-text available via subscription   (Followers: 1)
ChemCatChem     Hybrid Journal   (Followers: 8)
Chemical and Engineering News     Free   (Followers: 18)
Chemical Bulletin of Kazakh National University     Open Access  
Chemical Communications     Full-text available via subscription   (Followers: 73)
Chemical Engineering Research and Design     Hybrid Journal   (Followers: 26)
Chemical Research in Chinese Universities     Hybrid Journal   (Followers: 3)
Chemical Research in Toxicology     Full-text available via subscription   (Followers: 22)
Chemical Reviews     Full-text available via subscription   (Followers: 191)
Chemical Science     Open Access   (Followers: 24)
Chemical Technology     Open Access   (Followers: 24)
Chemical Vapor Deposition     Hybrid Journal   (Followers: 5)
Chemie in Unserer Zeit     Hybrid Journal   (Followers: 56)
Chemie-Ingenieur-Technik (Cit)     Hybrid Journal   (Followers: 24)
ChemInform     Hybrid Journal   (Followers: 8)
Chemistry & Biodiversity     Hybrid Journal   (Followers: 7)
Chemistry & Biology     Full-text available via subscription   (Followers: 32)
Chemistry & Industry     Hybrid Journal   (Followers: 7)
Chemistry - A European Journal     Hybrid Journal   (Followers: 161)
Chemistry - An Asian Journal     Hybrid Journal   (Followers: 16)
Chemistry and Materials Research     Open Access   (Followers: 21)
Chemistry Central Journal     Open Access   (Followers: 4)
Chemistry Education Research and Practice     Free   (Followers: 5)
Chemistry in Education     Open Access   (Followers: 9)
Chemistry International     Hybrid Journal   (Followers: 2)
Chemistry Letters     Full-text available via subscription   (Followers: 44)
Chemistry of Materials     Full-text available via subscription   (Followers: 252)
Chemistry of Natural Compounds     Hybrid Journal   (Followers: 9)
Chemistry World     Full-text available via subscription   (Followers: 19)
Chemistry-Didactics-Ecology-Metrology     Open Access   (Followers: 1)
ChemistryOpen     Open Access   (Followers: 1)
Chemkon - Chemie Konkret, Forum Fuer Unterricht Und Didaktik     Hybrid Journal  
Chemoecology     Hybrid Journal   (Followers: 4)
Chemometrics and Intelligent Laboratory Systems     Hybrid Journal   (Followers: 14)
Chemosensors     Open Access  
ChemPhysChem     Hybrid Journal   (Followers: 11)
ChemPlusChem     Hybrid Journal   (Followers: 2)
ChemTexts     Hybrid Journal  
CHIMIA International Journal for Chemistry     Full-text available via subscription   (Followers: 2)
Chinese Journal of Chemistry     Hybrid Journal   (Followers: 6)
Chinese Journal of Polymer Science     Hybrid Journal   (Followers: 11)
Chromatographia     Hybrid Journal   (Followers: 24)
Chromatography     Open Access   (Followers: 2)
Chromatography Research International     Open Access   (Followers: 6)
Clay Minerals     Full-text available via subscription   (Followers: 10)
Cogent Chemistry     Open Access   (Followers: 1)
Colloid and Interface Science Communications     Open Access  
Colloid and Polymer Science     Hybrid Journal   (Followers: 11)
Colloids and Interfaces     Open Access  
Colloids and Surfaces B: Biointerfaces     Hybrid Journal   (Followers: 6)
Combinatorial Chemistry & High Throughput Screening     Hybrid Journal   (Followers: 4)
Combustion Science and Technology     Hybrid Journal   (Followers: 22)
Comments on Inorganic Chemistry: A Journal of Critical Discussion of the Current Literature     Hybrid Journal   (Followers: 2)
Communications Chemistry     Open Access  
Composite Interfaces     Hybrid Journal   (Followers: 7)
Comprehensive Chemical Kinetics     Full-text available via subscription   (Followers: 1)
Comptes Rendus Chimie     Full-text available via subscription  
Comptes Rendus Physique     Full-text available via subscription   (Followers: 1)
Computational and Theoretical Chemistry     Hybrid Journal   (Followers: 9)
Computational Biology and Chemistry     Hybrid Journal   (Followers: 11)
Computational Chemistry     Open Access   (Followers: 2)
Computers & Chemical Engineering     Hybrid Journal   (Followers: 10)
Coordination Chemistry Reviews     Full-text available via subscription   (Followers: 3)
Copernican Letters     Open Access   (Followers: 1)
Corrosion Series     Full-text available via subscription   (Followers: 6)
Critical Reviews in Biochemistry and Molecular Biology     Hybrid Journal   (Followers: 5)
Croatica Chemica Acta     Open Access  
Crystal Structure Theory and Applications     Open Access   (Followers: 4)
CrystEngComm     Full-text available via subscription   (Followers: 13)
Current Catalysis     Hybrid Journal   (Followers: 2)
Current Chromatography     Hybrid Journal  
Current Green Chemistry     Hybrid Journal  
Current Metabolomics     Hybrid Journal   (Followers: 5)
Current Microwave Chemistry     Hybrid Journal  
Current Opinion in Colloid & Interface Science     Hybrid Journal   (Followers: 9)
Current Opinion in Molecular Therapeutics     Full-text available via subscription   (Followers: 14)
Current Research in Chemistry     Open Access   (Followers: 8)
Current Science     Open Access   (Followers: 69)
Current Trends in Biotechnology and Chemical Research     Open Access   (Followers: 3)
Dalton Transactions     Full-text available via subscription   (Followers: 23)
Detection     Open Access   (Followers: 2)
Developments in Geochemistry     Full-text available via subscription   (Followers: 2)
Diamond and Related Materials     Hybrid Journal   (Followers: 12)
Dislocations in Solids     Full-text available via subscription  

        1 2 3 4 | Last

Journal Cover Arabian Journal of Chemistry
  Journal Prestige (SJR): 0.512
  Citation Impact (citeScore): 20
  Number of Followers: 6  
    
  This is an Open Access Journal Open Access journal
   ISSN (Print) 1878-5352
   Published by Elsevier Homepage  [3162 journals]
  • Cyclic voltammetry, square wave voltammetry, electrochemical impedance
           spectroscopy and colorimetric method for hydrogen peroxide detection based
           on chitosan/silver nanocomposite

    • Authors: Hoang V. Tran; Chinh D. Huynh; Hanh V. Tran; Benoit Piro
      Pages: 453 - 459
      Abstract: Publication date: May 2018
      Source:Arabian Journal of Chemistry, Volume 11, Issue 4
      Author(s): Hoang V. Tran, Chinh D. Huynh, Hanh V. Tran, Benoit Piro
      In this paper, we demonstrate a promising method to fabricate a non-enzymatic stable, highly sensitive and selective hydrogen peroxide sensor based on a chitosan/silver nanoparticles (CS/AgNPs) hybrid. Using this composite, we elaborated both electrochemical and colorimetric sensors for hydrogen peroxide detection. The colorimetric sensor is based on a homogenous reaction which fades the color of CS/AgNPs solutions from red-orange to colorless depending on hydrogen peroxide concentration. For the electrochemical sensor, CS/AgNPs were immobilized on glassy carbon electrodes and hydrogen peroxide was measured using cyclic voltammetry, square wave voltammetry and electrochemical impedance spectroscopy. The response time is less than 10s and the detection limit is 5μM.

      PubDate: 2018-05-29T00:37:00Z
      DOI: 10.1016/j.arabjc.2016.08.007
       
  • Facile LaOF: Sm3+ based labeling agent and their applications in residue
           chemistry of latent fingerprint and cheiloscopy under UV–visible light

    • Authors: C. Suresh; H. Nagabhushana; G.P. Darshan; R.B. Basavaraj; D. Kavyashree; S.C. Sharma; A. Arulmozhi; B. Daruka Prasad; H.J. Amith Yadav
      Pages: 460 - 482
      Abstract: Publication date: May 2018
      Source:Arabian Journal of Chemistry, Volume 11, Issue 4
      Author(s): C. Suresh, H. Nagabhushana, G.P. Darshan, R.B. Basavaraj, D. Kavyashree, S.C. Sharma, A. Arulmozhi, B. Daruka Prasad, H.J. Amith Yadav
      Luminescent lanthanum oxyfluoride nano inorganic materials were considered to be prospective building blocks for multifunctional applications. This offers new potentials in surface-based science comprising of visualization of latent fingerprint (LFPs) and lips print on non-porous surfaces. Traditional visualization techniques possess high backward hindrance, low sensitivity, complicated setup and poor visibility. To overcome with these problems, LaOF:Sm3+ (5 mol%) nanopowder (NPs) prepared via sonochemical route were explored. Photoluminescence (PL) emission spectra exhibit strong emission peaks at ∼566 nm, 607 nm, 653 nm and 708 nm attributed to 4G5/2 → 6H5/2, 4G5/2 → 4H7/2, 4G5/2 → 6H9/2 and 4G5/2 → 6H11/2 intra-4f orbital transitions of Sm3+ ions respectively. Estimated photometric properties confirm that the material emits warm orange red color. Therefore, the synthesized phosphor materials may quite be useful for LFPs recovery, cheiloscopy and optoelectronics applications.
      Graphical abstract image

      PubDate: 2018-05-29T00:37:00Z
      DOI: 10.1016/j.arabjc.2017.09.014
       
  • Validated electroanalytical determination of flavoxate hydrochloride and
           tolterodine tartrate drugs in bulk, dosage forms and urine using modified
           carbon paste electrodes

    • Authors: Ali K. Attia; Eman Y.Z. Frag; Heba E. Ahmed
      Pages: 483 - 491
      Abstract: Publication date: May 2018
      Source:Arabian Journal of Chemistry, Volume 11, Issue 4
      Author(s): Ali K. Attia, Eman Y.Z. Frag, Heba E. Ahmed
      Simple, precise, inexpensive and sensitive voltammetric methods have been developed for the determination of flavoxate HCl (FLXHC) and tolterodine tartrate (TOLT) in the bulk, pharmaceutical dosage forms and human urine using ferrocene modified carbon paste electrode (FMCPE) for FLXHC and polyethylene glycol modified carbon paste electrode (PEGMCPE) for TOLT. The electrochemical behavior of FLXHC and TOLT showed irreversible diffusion-controlled oxidation processes in Britton-Robinson (BR) buffer over the entire pH range from 2 to 6 for FLXHC and from 2 to 9 for TOLT. The peak current was evaluated as a function of some variables such as pH, scan rate and number of cycles of ferrocenium solution and PEG concentration. The linear ranges were 7.8×10−6–1.2×10−4 molL−1 and 7.6×10−7–2.2×10−4 molL−1 for FLXHC and TOLT, respectively. The limits of detection and quantification were 5.9×10−7 and 2×10−6 for FLXHC and 8.6×10−8 molL−1 and 2.9×10−7 molL−1 for TOLT. The percentage recoveries were found in the following ranges: 99.2–101.1% and 99.7–101.1% for FLXHC and TOLT, respectively.
      Graphical abstract image

      PubDate: 2018-05-29T00:37:00Z
      DOI: 10.1016/j.arabjc.2016.07.015
       
  • Free fluoride determination in honey by ion-specific electrode
           potentiometry: Method assessment, validation and application to real
           unifloral samples

    • Authors: Nadia Spano; Valentina Guccini; Marco Ciulu; Ignazio Floris; Valeria M. Nurchi; Angelo Panzanelli; Maria I. Pilo; Gavino Sanna
      Pages: 492 - 500
      Abstract: Publication date: May 2018
      Source:Arabian Journal of Chemistry, Volume 11, Issue 4
      Author(s): Nadia Spano, Valentina Guccini, Marco Ciulu, Ignazio Floris, Valeria M. Nurchi, Angelo Panzanelli, Maria I. Pilo, Gavino Sanna
      Surprisingly, a reliable method for measuring the concentration of free fluoride ions in honey is still missing from the literature, notwithstanding the generally recognized importance of the analyte and the matrix. To fill this gap, this study proposes and validates a straightforward ion-specific electrode potentiometric method for this task. The method offers very low detection and quantification limits (6.7μgkg− 1 and 25μgkg− 1, respectively), good linearity (R 2 >0.994), good sensitivity (typically 55±3mV for an order of magnitude of concentration) in an unusually low concentration interval (between 0.020 and 1mgL− 1), and acceptable precision and bias. The method was applied to 30 unifloral (thistle, eucalyptus and strawberry tree) honey samples from Sardinia, Italy. The amount of free fluoride ions found in these honeys appears to be lower than the range usually found in the literature; indeed, early results suggest a possible dependence of the analyte concentration on the honey’s botanical origin.

      PubDate: 2018-05-29T00:37:00Z
      DOI: 10.1016/j.arabjc.2014.12.010
       
  • Synergism of thiocyanate ions and microinterfacial surface as driving
           forces for heavy multi-metals extraction

    • Authors: Daniela Cadar; Nicoleta Liliana Olteanu; Elena Adina Andrei; Adina Roxana Petcu; Cosmina Andreea Marin; Aurelia Meghea; Maria Mihaly
      Pages: 501 - 512
      Abstract: Publication date: May 2018
      Source:Arabian Journal of Chemistry, Volume 11, Issue 4
      Author(s): Daniela Cadar, Nicoleta Liliana Olteanu, Elena Adina Andrei, Adina Roxana Petcu, Cosmina Andreea Marin, Aurelia Meghea, Maria Mihaly
      A comprehensive study has been carried out to evaluate the extraction of heavy metals mixture (Co2+, Cr3+, Cu2+, Ni2+) from aqueous media by Winsor II non-ionic microemulsion, containing polyoxyethylene (4) lauryl ether as non-ionic surfactant and butyl acetate as organic phase. The extraction mechanism is based on the formation of thiocyanate complexes of metals and their transfer from aqueous to microemulsion phase, either towards the interfacial film of surfactant (Co2+) or into the core of micelles (Cr3+, Cu2+, Ni2+). The value of the distribution coefficient for Co2+ was higher than for the other studied metals and its extraction efficiency was not dependent on the working conditions, showing a maximum value (99.99%) in all cases. By using successive extractions, chromium, nickel and copper ions that remained in the aqueous phase after first extraction were transported into the microemulsion phase, leading to an increase in the extraction efficiency up to 99.99% for chromium and copper, and 85% for nickel. Based on pH influence, a selective extraction of Co2+ and Cr3+ can be achieved, since the cobalt ions were completely extracted into the microemulsion phase at pH = 1, and the chromium ions still remained in the aqueous phase.

      PubDate: 2018-05-29T00:37:00Z
      DOI: 10.1016/j.arabjc.2017.11.018
       
  • Winter wild fennel leaves as a source of anti-inflammatory and antioxidant
           polyphenols

    • Authors: Severina Pacifico; Silvia Galasso; Simona Piccolella; Nadine Kretschmer; San-Po Pan; Paola Nocera; Annamaria Lettieri; Rudolf Bauer; Pietro Monaco
      Pages: 513 - 524
      Abstract: Publication date: May 2018
      Source:Arabian Journal of Chemistry, Volume 11, Issue 4
      Author(s): Severina Pacifico, Silvia Galasso, Simona Piccolella, Nadine Kretschmer, San-Po Pan, Paola Nocera, Annamaria Lettieri, Rudolf Bauer, Pietro Monaco
      In the course of a screening program on the seasonal phenol composition of wild Mediterranean medicinal and aromatic plants, broadly used for culinary purposes, Foeniculum vulgare Mill. was the focus of the present study. Hydroalcoholic extracts from fennel freeze-dried leaves, collected in different seasons along 2012 and 2013years, were quali-quantitatively analyzed through LC/MS/MS techniques. Winter extract contained, beyond several hydroxycinnamoyl quinic acids and flavonol glycosides, two chromone derivatives. Flavonol hexuronides were the main spring sample constituents. Phenol profile differences among the extracts influenced massively their bioactivity. When the antioxidant screening was performed, winter extract effectively scavenged DPPH and ABTS + and reduced Fe3+. Although all the extracts did not show cytotoxicity, they were differently able to exert cytoprotection in H2O2-oxidized cell systems and to affect COX-2 gene expression in THP-1 cells. The most active one was winter extract, which inhibited COX-2 expression by 40%, whereas spring sample showed a weak pro-inflammatory capability.

      PubDate: 2018-06-01T00:55:15Z
      DOI: 10.1016/j.arabjc.2015.06.026
       
  • Synthesis and antioxidant study of new polyphenolic hybrid-coumarins

    • Authors: Karina Pérez-Cruz; Mauricio Moncada-Basualto; Javier Morales-Valenzuela; Germán Barriga-González; Patricio Navarrete-Encina; Luis Núñez-Vergara; J.A. Squella; Claudio Olea-Azar
      Pages: 525 - 537
      Abstract: Publication date: May 2018
      Source:Arabian Journal of Chemistry, Volume 11, Issue 4
      Author(s): Karina Pérez-Cruz, Mauricio Moncada-Basualto, Javier Morales-Valenzuela, Germán Barriga-González, Patricio Navarrete-Encina, Luis Núñez-Vergara, J.A. Squella, Claudio Olea-Azar
      The antioxidant capacity of hydroxylated coumarins and hydroxybenzoic acids has been widely described. However, there is little information on the antioxidant activity when both systems are functionalized. In this work, new hybrid compounds synthesis with a common coumarin scaffold and hydroxybenzoic acids is described. Their antioxidant capacity was evaluated against reactive oxygen species (ROS) using oxygen radical absorbance capacity-fluorescein (ORAC-FL), electron spin resonance (ESR) spin trapping, quenching of superoxide anion, cellular antioxidant activity (CAA) and a ferric reducing ability of plasma (FRAP assay). Additionally, the local reactivity indicator (Fukui index) was calculated to discriminate different reactive sites in the new molecules in which the oxidative process occurs. Likewise, the BDE values were calculated in order to obtain information about the antioxidant capacity for HAT mechanisms. The insertion of organic phenols in a simple coumarin structure produced new derivatives with an improved antioxidant capacity in relation to coumarin 1a. For compound 3c, a synergy phenomenon in ORAC-FL and the FRAP test was observed. For compound 3b, this phenomenon was observed in the superoxide scavenging test. According to the CAA assay results, the activity of the new compounds is limited to those oxidative processes in lipophilic media (e.g., bio membranes).
      Graphical abstract image

      PubDate: 2018-05-29T00:37:00Z
      DOI: 10.1016/j.arabjc.2017.05.007
       
  • Microwave-assisted intermolecular aldol condensation: Efficient one-step
           synthesis of 3-acetyl isocoumarin and optimization of different reaction
           conditions

    • Authors: Murat Koca; Ali S. Ertürk; Adil Umaz
      Pages: 538 - 545
      Abstract: Publication date: May 2018
      Source:Arabian Journal of Chemistry, Volume 11, Issue 4
      Author(s): Murat Koca, Ali S. Ertürk, Adil Umaz
      This paper describes the optimization and comparison of conventional and microwave-assisted methods for efficient, cheap, one-pot, and straightforward synthesis of isocoumarins under mild reaction conditions. On this basis of this aim, synthesis of 3-acetyl isocoumarin from 2-formylbenzoic acid with mono-chloroacetone was chosen as a model reaction. Afterward, four different methods conventional (Method A), microwave open vessel (Method B), microwave sealed vessel (Method C), and microwave closed system (Method D) were used methodologically to determine best experimental conditions for each of these methods in this model reaction. The results revealed that developed Methods A, C and D could be used successfully under solvent-free conditions with good yields (84–87%) for the future efficient, one-pot synthesis of isocoumarins. This paper is also a first for characterizing 3-acetyl isocoumarin by using ATR, 1H NMR, 13C NMR and GC–MS.

      PubDate: 2018-05-29T00:37:00Z
      DOI: 10.1016/j.arabjc.2015.11.013
       
  • Production of biodegradable plastic from agricultural wastes

    • Authors: N.A. Mostafa; Awatef A. Farag; Hala M. Abo-dief; Aghareed M. Tayeb
      Pages: 546 - 553
      Abstract: Publication date: May 2018
      Source:Arabian Journal of Chemistry, Volume 11, Issue 4
      Author(s): N.A. Mostafa, Awatef A. Farag, Hala M. Abo-dief, Aghareed M. Tayeb
      Agricultural residues management is considered to be a vital strategy in order to accomplish resource conservation and to maintain the quality of the environment. In recent years, biofibers have attracted increasing interest due to their wide applications in food packaging and in the biomedical sciences. These eco-friendly polymers reduce rapidly and replace the usage of the petroleum-based synthetic polymers due to their safety, low production costs, and biodegradability. This paper reports an efficient method for the production of the cellulose acetate biofiber from flax fibers and cotton linters. The used process satisfied a yield of 81% and 54% for flax fibers and cotton linters respectively (based on the weight of the cellulosic residue used). The structure of the produced bioplastic was confirmed by X-ray diffraction, FT-IR and gel permeation chromatography. Moreover, this new biopolymer is biodegradable and is not affected by acid or salt treatment but is alkali labile. A comparison test showed that the produced cellulose acetate was affected by acids to a lesser extent than polypropylene and polystyrene. Therefore, this new cellulose acetate bioplastics can be applied in both the food industry and medicine.

      PubDate: 2018-05-29T00:37:00Z
      DOI: 10.1016/j.arabjc.2015.04.008
       
  • A theoretical assessment of antioxidant capacity of flavonoids by means of
           local hyper–softness

    • Authors: Claudia Sandoval-Yañez; Carolina Mascayano; Jorge I. Martínez-Araya
      Pages: 554 - 563
      Abstract: Publication date: May 2018
      Source:Arabian Journal of Chemistry, Volume 11, Issue 4
      Author(s): Claudia Sandoval-Yañez, Carolina Mascayano, Jorge I. Martínez-Araya
      A theoretical reactivity descriptor to estimate local reactivity on molecules was tested to assess the antioxidant capability of some flavonoids. It was validated by comparison with experimental precedents published already by Firuzi et al. (2005). The aforementioned reactivity index is called local hyper-softness (LHS). This parameter was applied on HO- substituent groups on the same set of flavonoids within each subclassification: flavones (apigenin and baicalein), flavonols (fisetin, galangin, 3–OH flavone, kaempferol, myricetin, and quercetin), flavanones (hesperetin, naringenin, taxifolin) and isoflavones (daidzein and genistein). Experimental values of both techniques, ferric reducing antioxidant power (FRAP) and anodic oxidation potential (Eap) were retrieved from Firuzi et al. (2005) with the purpose of validating the calculated LHS values. Excepting myricetin, the LHS values of all these compounds matched in a similar order relationship experimentally obtained by means of Eap and FRAP from Firuzi et al. (2005). Our results revealed that LHS is a suitable theoretical parameter to get an insight concerning to the antioxidant capacity of these compounds, in particular, LHS allows explaining experimentally obtained values of FRAP along with Eap values in terms of reactivity of HO- substituent groups belonging these molecules theoretically computed without including experimental parametes.

      PubDate: 2018-05-29T00:37:00Z
      DOI: 10.1016/j.arabjc.2017.10.011
       
  • Influence of operational parameters on photocatalytic amitrole degradation
           using nickel organic xerogel under UV irradiation

    • Authors: Miguel A. Álvarez; Francisco Orellana-García; M. Victoria López-Ramón; José Rivera-Utrilla; Manuel Sánchez-Polo
      Pages: 564 - 572
      Abstract: Publication date: May 2018
      Source:Arabian Journal of Chemistry, Volume 11, Issue 4
      Author(s): Miguel A. Álvarez, Francisco Orellana-García, M. Victoria López-Ramón, José Rivera-Utrilla, Manuel Sánchez-Polo
      The objectives of this study were to analyze the influence of different operational variables and to determine the time course of total organic carbon (TOC) and medium toxicity during amitrole (AMT) photodegradation in the presence of Ni xerogel (X-Ni) as photocatalyst. A further study objective was to analyze the influence of the type of water on the photodegradation process. Results show that the degradation rate is directly proportional to the initial X-Ni concentration up to a maximum of 250mg/L with a slight decrease thereafter, indicating progressive photon absorption saturation of the catalyst for a given incident radiation flow. At concentrations close to 250mg/L X-Ni, the AMT photodegradation rate is not affected by further increases in X-Ni concentration. In addition, AMT photolysis is highly pH-dependent and is generally favored at pH values at which AMT is in its ionic form. The increase observed in AMT degradation rate under alkaline conditions can be attributed to the higher generation of HO radicals. The presence of chloride reduces the AMT degradation rate, because Cl− anions behave as h+ and HO radical scavengers. The degradation rate is also decreased by addition to the medium of organic matter, which acts as a filter. The behavior of TOC removal kinetics during AMT degradation in the presence of X-Ni is similar to that observed for AMT degradation kinetics. Finally, we highlight that photocatalysis is more effective in ultrapure water than in wastewater or tap water. In all systems, the optimal catalyst concentration is 250mg/L. The medium toxicity increases with longer treatment time, indicating the formation of by-products that are smaller than AMT and can more readily penetrate the cell.

      PubDate: 2018-05-29T00:37:00Z
      DOI: 10.1016/j.arabjc.2016.10.005
       
  • Design, synthesis and biological evaluation of new substituted
           5-benzylideno-2-adamantylthiazol[3,2-b][1,2,4]triazol-6(5H)ones.
           Pharmacophore models for antifungal activity

    • Authors: C. Tratrat; M. Haroun; A. Paparisva; A. Geronikaki; Ch. Kamoutsis; A. Ćirić; J. Glamočlija; M. Soković; Ch. Fotakis; P. Zoumpoulakis; Shome S. Bhunia; Anil K. Saxena
      Pages: 573 - 590
      Abstract: Publication date: May 2018
      Source:Arabian Journal of Chemistry, Volume 11, Issue 4
      Author(s): C. Tratrat, M. Haroun, A. Paparisva, A. Geronikaki, Ch. Kamoutsis, A. Ćirić, J. Glamočlija, M. Soković, Ch. Fotakis, P. Zoumpoulakis, Shome S. Bhunia, Anil K. Saxena
      As a part of our ongoing studies in developing new derivatives as antimicrobial agents we describe the synthesis of novel substituted 5-benzylideno-2-adamantylthiazol[3,2-b][1,2,4]triazol-6(5H)ones.The twenty-five newly synthesized compounds were tested for their antimicrobial and antifungal activity. All compounds have shown antibacterial properties with compounds 1–9 showing the lowest activity, followed by compounds 10–14 while compounds 15–25 the highest antibacterial activity. Specific compounds appeared to be more active than ampicillin in most studied strains and in some cases more active than streptomycin. Antifungal activity in most cases also was better than that of reference drugs ketoconazole and bifonazole. Elucidating the relation of molecular properties to antimicrobial activity as well as generation of pharmacophore model for antifungal activity of two fungal species Aspergillus fumigatus and Candida albicans were performed.

      PubDate: 2018-05-29T00:37:00Z
      DOI: 10.1016/j.arabjc.2016.06.007
       
  • Establishment of Analytical Method for Quantification of Anti-inflammatory
           Agents Co-nanoencapsulated and its Application to Physicochemical
           Development and Characterization of Lipid-Core Nanocapsules

    • Authors: Kelly Ayumi Nakama; Renata Bem dos Santos; Carlos Eduardo da Rosa Silva; Jessica Cristina Izoton; Anne Suely Pinto Savall; Maria Eduarda Ziani Gutirrez; Silvane Souza Roman; Cristiane Luchese; Simone Pinton; Sandra Elisa Haas
      Abstract: Publication date: Available online 31 May 2018
      Source:Arabian Journal of Chemistry
      Author(s): Kelly Ayumi Nakama, Renata Bem dos Santos, Carlos Eduardo da Rosa Silva, Jessica Cristina Izoton, Anne Suely Pinto Savall, Maria Eduarda Ziani Gutirrez, Silvane Souza Roman, Cristiane Luchese, Simone Pinton, Sandra Elisa Haas
      Anti-inflammatory agents may be alternatives for the treatment of Alzheimer's disease. Then, we propose the nanotechnology as a strategy to curcumin and meloxicam co-nanoencapsulation for neurodegenerative diseases treatment. In this study, we developed and validated an analytical method by HPLC-DAD for simultaneous quantification of curcumin and meloxicam in the same formulation. We applied this method to characterize curcumin, meloxican and curcumin plus meloxican loaded lipid-core nanocapsules (LNC): drug content, encapsulation efficiency, photostabilty and drug's distribution. Additionally, toxicity levels of the nanoparticles were evaluated in vivo (mice). Therefore a C18-RP column was used with a guard column packed with the same material as the stationary phase. Acetonitrile: methanol: water: triethylamine (52:5:43:0.3 v/v/v/v), was used as the mobile phase in the 1 mL.min-1 flow. Detection was 424 nm (curcumin) and 365 nm (meloxicam). The method was established in accordance with the current national and international guidelines, showing good linearity (r2 >0.999). The formulations showed exclusively nanosized particles, negative zeta potential and slightly acidic pH, with content and encapsulation rate close to 100%. The distributions of meloxicam and curcumin in the LNC (alone or co-encapsulated) were type III and type VI, respectively. LNC were able to protect both drugs against UVA degradation. In vivo experiments showed no toxicity in relation to the parameters determined of all LNC evaluated in mice. In this work, we showed the possibility to carry meloxicam and curcumin in LNC with good technological characteristics and without toxicity in vivo with prospects for the treatment of Alzheimer's disease in sequential pharmacological studies.
      Graphical abstract image

      PubDate: 2018-06-01T00:55:15Z
      DOI: 10.1016/j.arabjc.2018.05.011
       
  • Optimization and detailed stability study on coupling of CdMoO4 into BaWO4
           for enhanced photodegradation and removal of organic contaminant

    • Authors: Mohammad Eghbali-Arani; Saeid Pourmasoud Farhad Ahmadi Mehdi Rahimi-Nasrabadi Vahid Ameri
      Abstract: Publication date: Available online 30 May 2018
      Source:Arabian Journal of Chemistry
      Author(s): Mohammad Eghbali-Arani, Saeid Pourmasoud, Farhad Ahmadi, Mehdi Rahimi-Nasrabadi, Vahid Ameri, Ali Sobhani-Nasab
      BaWO4 nanoparticles BaWO4/CdMoO4 nanocomposites were synthesized by eco-friendly method at low temperature. The effects of various capping agents such as glucose, fructose, lactose, and starch on the morphology and particle size of BaWO4/CdMoO4 nanocomposites were investigated. The nanocluster was obtained with glucose and Ba2+ to capping agent molar ratio of (1:2). BaWO4/CdMoO4 nanocomposites were analyzed through techniques including, XRD, FT-IR, VSM, TEM, PL, FESEM, UV-Vis, and EDX. According to the BET results, in the presence of glucose as the capping agent, surface area increased from 13.781 m2/g to 122.22 m2/g. Furthermore, adding CdMoO4 nanoparticles to BaWO4 causes optical properties and photocatalytic activity of BaWO4 to improve. Moreover, the effects of several factors such as BaWO4/CdMoO4 nanocomposites concentration and its particle size and difference dyes on the photocatalytic performance of BaWO4/CdMoO4 nanocomposites were studied under visible light.

      PubDate: 2018-06-01T00:55:15Z
       
  • Green Synthesis of Platinum Nanoparticles Using Saudi’s Dates Extract
           and their Usage on The Cancer Cell Treatment

    • Authors: Najlaa S. Al-Radadi
      Abstract: Publication date: Available online 29 May 2018
      Source:Arabian Journal of Chemistry
      Author(s): Najlaa S. Al-Radadi
      Green synthesis of the Platinum nanoparticle of dates is carried out for examining their effect on various cancer cells. The extract solution of Dates (biodegradable surfactant) is used for this purpose. The bio-degradable plant-based surfactant, used in the study, occurs naturally, and no other reducing, or capping agent is used for cancer cell treatment. The aqueous extract solution of popular dates Ajwa and Barni acts as a stabilizing and reducing agent during the production of PtNPs at ambient condition because of simplicity, long-time stability, and cost-effectiveness. In order to achieve the best size and shape of nanoparticles, different ratio of extract and metal salt were mixed and developed. Additionally, nanoparticles of varying size were furnished by altering the pH of the reaction. Spectroscopic techniques like FTIR, X-ray Diffraction (XRD), EDX, thermos-gravimetric analysis (TGA), UV-vis, and transmission electron microscopy (TEM) were applied to identify PtNPs. In this study, electrochemical HPCL and high-performance liquid chromatography (HPCL) are combined for better understanding and effectiveness. The metabolites such as amino acid, sugar, organic acid, flavonoids, phenol, and minerals, in the Dates produced in Al-Madinah Al-Munawarah, have been analyzed with the help of the techniques employed in the study. PtNPs' anticancer activities were evaluated for different cancer cells including the colon carcinoma cells (HCT-116), breast cells (MCF-7), and hepatocellular carcinoma (HePG-2). Commonly used effective anticancer agent, Doxorubicin HCl, is used in the current study related to anticancer activitiy. To discover the antibacterial effect, antibacterial agents Ampicillin and Gentamicin are used. Lastly, the Gram-negative bacteria: Escherichia coli (RCMB 010052) and Gram-Positive Bacteria: Bacillus subtilis (RCMB 010067) were used to determine the antibacterial application of PtNPs.

      PubDate: 2018-06-01T00:55:15Z
      DOI: 10.1016/j.arabjc.2018.05.008
       
  • Construction of High Efficient g-C3N4 Nanosheets combined with Bi2MoO6-Ag
           Photocatalysts for Visible-Light-Driven Photocatalytic Activity and
           inactivation’s of Bacteria’s

    • Authors: Shanmugam Vignesh; Muppudathi Anna Lakshmi; J. Sridhar; Jeyaperumal Kalyana Sundar
      Abstract: Publication date: Available online 29 May 2018
      Source:Arabian Journal of Chemistry
      Author(s): Shanmugam Vignesh, Muppudathi Anna Lakshmi, J. Sridhar, Jeyaperumal Kalyana Sundar
      Novel g-C3N4-Bi2MoO6-Ag nanocomposite with their g-C3N4 nanosheets was synthesized by a facile hydrothermal method. The superior photocatalytic performance of gC3N4-Bi2MoO6-Ag nanocomposite was owing to the interface of Bi2MoO6/Ag nanomaterials whereas reduced the bandgap which enables high separation efficiency, suppressed recombination rate of charge carriers and their high specific surface area (97.4 cm3 g−1). For the MB dye degradation efficiency accomplishes 99.6% within 80 min under the visible light. Significantly, the ideal photocatalytic activity of gC3N4-Bi2MoO6-Ag composite has 3.63 times faster than pristine g-C3N4. Based on the trapping test, the superoxide radical O2 •- and hydroxyl radical (OH . ) plays a vital role in dye degradation in chief g-C3N4-Bi2MoO6-Ag nanocomposite under the visible light exposure. Novel gC3N4-Bi2MoO6-Ag catalyst has been exhibited superior electrochemical performance, which is smaller charge transfer resistance (impedance), and the prime photocurrent response has confirmed that more charge carrier abilities. The physicochemical assemblies and high degradation efficiencies were preserved after five successive cycles, whereas signifying that the sample was displayed good stability. Based on the consistent energy band positions, the probable mechanism for heightening photocatalytic activity was proposed. This study delivers a visible light driven novel g-C3N4-Bi2MoO6-Ag photocatalyst is a capable aspirant material and applicable for environmental remediation. Also, the antibacterial activity is well exposed towards disinfection of the bacterial strain, including pathogens which are S. aureus (G+) and E. coli (G-) bacteria’s.

      PubDate: 2018-06-01T00:55:15Z
      DOI: 10.1016/j.arabjc.2018.05.009
       
  • Fabrication and Characterization of Supported Dual Acidic Ionic Liquids
           for Polymer Electrolyte Membrane Fuel Cell Applications

    • Authors: Masoumeh Zakeri; Ebrahim Abouzari-Lotf; Mohamed Mahmoud Nasef; Arshad Ahmad; Mikio Miyake; Ting Teo Ming; Paveswari Sithambaranathan
      Abstract: Publication date: Available online 29 May 2018
      Source:Arabian Journal of Chemistry
      Author(s): Masoumeh Zakeri, Ebrahim Abouzari-Lotf, Mohamed Mahmoud Nasef, Arshad Ahmad, Mikio Miyake, Ting Teo Ming, Paveswari Sithambaranathan
      In this study, we proposed an innovative and versatile method for preparation of highly stable and conductive supported ionic liquid (IL) membranes for proton exchange fuel cell applications. Novel covalently supported dual acidic IL membranes were prepared by radiation induced grafting of 4-vinyl pyridine (4-VP) onto poly(ethylene-co-tetrafluoroethylene) (ETFE) film followed by post-functionalization via sequential treatments with 1,4-butane sultone and sulfuric acid to introduce pyridinium alkyl sulfonate/hydrogen sulfate moieties. The advantage of our approach lies in grafting polymers with highly reactive functional groups suitable for efficient post-sulfonation. The membranes displayed better swelling and mechanical properties compared to Nafion 112 despite having more than 3 times higher ion exchange capacity (IEC). The proton conductivity reached superior values to Nafion above 80 °C. Particularly, the membrane with ion exchange capacity of 3.41 displayed a proton conductivity of 259 mScm−1 at 95 °C. This desired conductivity value is attributed to the high IEC of the membranes as well as dissociation of the hydrophobic ETFE polymer and hydrophilic pyridinium alkyl sulfonate groups. Such appealing properties make the supported IL membranes promising for proton exchange membrane fuel cells (PEMFC).

      PubDate: 2018-06-01T00:55:15Z
      DOI: 10.1016/j.arabjc.2018.05.010
       
  • Synthesis of 2D boron nitride doped polyaniline hybrid nanocomposites for
           photocatalytic degradation of carcinogenic dyes from aqueous solution

    • Authors: Syed Shahabuddin; Rashmin Khanam; Mohammad Khalid; Norazilawati Muhamad Sarih; Juan Joon Ching; Sharifah Mohamad; R. Saidur
      Abstract: Publication date: Available online 19 May 2018
      Source:Arabian Journal of Chemistry
      Author(s): Syed Shahabuddin, Rashmin Khanam, Mohammad Khalid, Norazilawati Muhamad Sarih, Juan Joon Ching, Sharifah Mohamad, R. Saidur
      This investigation focused on the photocatalytic treatment of pollutants in waste water using methylene blue (MB) and methyl orange (MO) as the model dyes. In this study, conducting polyaniline (PANI) based nanocomposites doped with 2D hexagonal boron nitride (h-BN) were synthesised using simplistic oxidative in-situ polymerization technique by employing ammonium persulfate as an initiator in acidic medium. The synthesised 2D h-BN doped PANI nanocomposites were comprehensively characterized using field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), elemental mapping, X-ray diffraction (XRD), Brunauer-Emmett-Teller analysis (BET), thermogravimetric analysis (TGA), and Fourier transform infrared spectroscopy (FTIR). Degradation of MB and MO dyes under UV irradiations was performed to evaluate the photocatalytic performance of the synthesised nanocomposites. The results indicated that the h-BN nanosheets doped nanocomposites demonstrated better photocatalytic activities as compared to bare PANI or h-BN. Moreover, the nanocomposite P-BN-2, with 2 wt% of 2D h-BN nanosheets was found to be an optimal composition with 93% and 95% degradation efficiency for MB and MO within 90 min respectively.
      Graphical abstract image

      PubDate: 2018-05-29T00:37:00Z
      DOI: 10.1016/j.arabjc.2018.05.004
       
  • Fluorinated phosphonate analogues of phenylalanine: Synthesis, X-ray and
           DFT studies

    • Authors: Joanna Kwiczak-Yiğitbaşı; Jean-Luc Pirat; David Virieux; Jean-Noël Volle; Agnieszka Janiak; Marcin Hoffmann; Donata Pluskota-Karwatka
      Abstract: Publication date: Available online 19 May 2018
      Source:Arabian Journal of Chemistry
      Author(s): Joanna Kwiczak-Yiğitbaşı, Jean-Luc Pirat, David Virieux, Jean-Noël Volle, Agnieszka Janiak, Marcin Hoffmann, Donata Pluskota-Karwatka
      Due to their biological activity and structural analogy to corresponding α-amino acids, α-aminophosphonates and their fluorinated derivatives provide an important source for drug discovery. Therefore convenient access to this class of compounds is still desirable. Four series of novel phosphonate analogues of fluorinated phenylalanine containing variable number of fluorine atoms in different positions of the phenyl ring were synthesized and subjected to solid state characterization by single-crystal X-ray diffraction analysis, and to studies with the use of NMR, HRMS and DFT methods. Such an approach provided valuable information in regard to preferable conformation, hydrogen bonds and also weak intermolecular interactions present in the crystals investigated. As analogues of naturally occurring compounds, the obtained α-aminophosphonates have a big potential for biological activity. Formation of some indolinylphosphonates as minor products arisen from intramolecular SNAr reactions show that aminophosphonates exhibiting an electronically depleted aromatic group, and possessing a fluorine atom in ortho position of the phosphonoalkyl substituent may give an entrance to further derivatives that may exhibit entirely new properties.
      Graphical abstract image

      PubDate: 2018-05-29T00:37:00Z
      DOI: 10.1016/j.arabjc.2018.05.002
       
  • Cr(II)-promoted internal cyclization of acyclic enediynes fused to
           benzo[b]thiophene core: macrocycles versus 2-methylenecycloalkan-1-ols
           formation

    • Authors: A.E. Kulyashova; A.V. Ponomarev; S.I. Selivanov; A.F. Khlebnikov; V.V. Popik; I.A. Balova
      Abstract: Publication date: Available online 18 May 2018
      Source:Arabian Journal of Chemistry
      Author(s): A.E. Kulyashova, A.V. Ponomarev, S.I. Selivanov, A.F. Khlebnikov, V.V. Popik, I.A. Balova
      The utility of the intramolecular Nozaki-type coupling for the synthesis of macrocyclic benzo[b]thiophene-fused enediynes has been explored. The starting acyclic enediynes were prepared by the iodocyclization of 2-(buta-1,3-diynyl)thioanisoles followed by the Sonogashira cross-coupling of the resulting iodo-substituted benzo[b]thiophene with corresponding acetylenes. We found that Cr(II)-promoted intramolecular cyclization of 7-[2-(iodoethynyl)benzo[b]thiophen-3-yl]hept-6-ynal and 7-[3-(iodoethynyl)benzo-[b]thiophen-2-yl]hept-6-ynal resulted in the formation of 11-membered macrocyclic enediynes, while both expected 10-membered enediynes cannot be produced under the Nozaki-type reaction from corresponding 6-[3-(iodoethynyl)benzo[b]thiophen-2-yl]hex-5-ynal and 6-[2-(iodoethynyl)benzo[b]thiophen-3-yl]hex-5-ynal. In this case instead of cycle closing, the reaction catalyzed by Ni(II) led to the attack on a proximal triple bond producing 2-methylenecycloalkane-1-ol fragments. The DFT analysis of the ring strain in the benzo[b]thiophene-fused 10- and 11-membered enediyne-containing cycle provides the plausible explanation of the observed regioselectivity.

      PubDate: 2018-05-29T00:37:00Z
      DOI: 10.1016/j.arabjc.2018.05.005
       
  • Incorporating MoFe alloys into reduced graphene oxide as counter electrode
           catalysts for dye-sensitized solar cells

    • Authors: Sangho Shin; Van-Duong Dao; Ho-Suk Choi
      Abstract: Publication date: Available online 18 May 2018
      Source:Arabian Journal of Chemistry
      Author(s): Sangho Shin, Van-Duong Dao, Ho-Suk Choi
      In this study, MoFe alloy decorated onto reduced graphene oxide (RGO) nanohybrids is successfully synthesized with various volume ratios of Fe to Mo precursors using a dry plasma reduction method at a low temperature and under atmospheric pressure and is introduced for the first time as an electrocatalyst for counter electrodes (CEs) in dye-sensitized solar cells (DSCs). As observed by HRSEM and TEM analyses, MoFe is successfully immobilized on a 3D network structure of RGO. Well-dispersed MoxFe1−x (0 ≤ x ≤ 1) NPs ranging in size from 2 to 6 nm are stabilized with RGO after co-reduction of the metal precursor ions and graphene oxide. The developed catalysts are then applied as CEs in DSCs. As a result, the Mo0.7Fe0.3/RGO nanohybrid exhibited the highest electrocatalytic activity, corresponding to the lowest charge transfer resistance of 0.11 Ω, among the electrodes tested. The DSC employing Mo0.7Fe0.3/RGO CEs exhibits 5.44% efficiency, which is higher than the 1.26, 4.54 and 4.53% efficiency rates for cells using RGO, Mo0Fe1/RGO and Mo1Fe0/RGO electrodes, respectively, due to the optimization of the catalytic activity and the electron conductivity of the developed materials. Note that the efficiency of the device using a Pt electrode was 5.36% under identical conditions. This study concludes that the CE based on the MoFe/RGO nanohybrid is a prospective substitute for Pt which can provide new opportunities for advancing high-efficiency DSCs. Furthermore, the developed catalysts can be applied to other applications, such as methanol oxidation and oxygen reduction reactions.

      PubDate: 2018-05-29T00:37:00Z
      DOI: 10.1016/j.arabjc.2018.05.006
       
  • Insight on the Structural Aspect of ENR-50/TiO2 Hybrid in KOH/C3H8O Medium
           Revealed by NMR Spectroscopy

    • Authors: Omar S. Dahham; Rosniza Hamzah; Mohamad Abu Bakar; Nik Noriman Zulkepli; Abdulkader M. Alakrach; Sam Sung Ting; Mohd Firdaus Omar; Tijjani Adam; Awad A. Al-rashdi
      Abstract: Publication date: Available online 18 May 2018
      Source:Arabian Journal of Chemistry
      Author(s): Omar S. Dahham, Rosniza Hamzah, Mohamad Abu Bakar, Nik Noriman Zulkepli, Abdulkader M. Alakrach, Sam Sung Ting, Mohd Firdaus Omar, Tijjani Adam, Awad A. Al-rashdi
      The ring-opening reactions (ROR) of epoxide groups in epoxidized natural rubber/titania (ENR-50/TiO2) hybrid in potassium hydroxide/isopropanol medium were examined using NMR spectroscopy and supported by the FTIR technique. The thermal behaviour of the hybrid was also studied using TG/DTG and DSC analyses. The 1H NMR results suggested that 16.82% of ROR occurred in the hybrid, while the 13C NMR results exhibited five new peaks at δ 19.5, 71.0, 73.7, 91.7 and 94.4 ppm in the hybrid. 2D NMR, such as HMQC, HMBC and COSY techniques, further scrutinized these assignments. The FTIR spectrum exhibited Ti-O-C characteristics via the peak at 1028 cm-1. The TG/DTG results showed four steps of thermal degradation at 44-148, 219-309, 331-489 and 629-810 °C due to the existence of Ti moieties along with a polymer chain mixture (intact and ring-opened epoxide groups) of ENR-50, which in turn led to an increase in the Tg value of the hybrid to 27 °C compared to that of purified ENR-50 at -17.72 °C.

      PubDate: 2018-05-29T00:37:00Z
      DOI: 10.1016/j.arabjc.2018.05.003
       
  • Preparation and characterization of inexpensive kaolin hollow fibre
           membrane (KHFM) prepared using phase inversion/sintering technique for the
           efficient separation of real oily wastewater

    • Authors: Siti Khadijah Hubadillah; Mohd Hafiz Dzarfan Othman; Mukhlis A. Rahman; A.F. Ismail; Juhana Jaafar
      Abstract: Publication date: Available online 15 May 2018
      Source:Arabian Journal of Chemistry
      Author(s): Siti Khadijah Hubadillah, Mohd Hafiz Dzarfan Othman, Mukhlis A. Rahman, A.F. Ismail, Juhana Jaafar
      A low-cost kaolin hollow fiber membrane (KHFM) with unique finger-like and sponge-like structures was successfully fabricated by utilizing cheap and abundantly available kaolin clay as the starting material via phase inversion/sintering technique. In this study, mixing kaolin particles prepare the ceramic suspension, dispersant, polymer binder, and solvent using a planetary ball mill. This process is then followed by extrusion at various kaolin contents, bore fluid flow rates, and sintering temperatures ranging from 1200 to 1500 °C. The effect of calcium carbonate (CaCO3) content and polyethylene glycol (PEG) molecular weight as a function of pore agents are also discussed. Membrane characterizations were performed in terms of morphology, pore size distribution, porosity, mechanical strength, contact angle value, and pure water flux. The performance of membranes towards oil-in-water separation was conducted using oily wastewater samples taken from three points in Johor, Malaysia which were Kluang Oil Palm Mill Sdn. Bhd. in Kluang district, a car wash in Taman Skudai Baru in Johor Bahru district, and Meranti café, Universiti Teknologi Malaysia (UTM). The optimum parameters in fabricating the inexpensive KHFM were identified. It was found that the increase of kaolin content, bore fluid flow rate, and sintering temperature gave insignificant effect in the formation of finger–like structure but the process can be used to find a defect-free (i.e., rounded lumen and sufficient thickness) hollow fiber membrane shape. Interestingly, the finger-like structure can be controlled by the addition of PEG as a pore agent at different molecular weights. KHFM prepared with PEG 30,000 as a pore agent offered the highest oil rejection of 99.99% of turbidity and total organic carbon (TOC), and 91.8% of chemical oxygen demand (COD) with stable high flux of 320 L/m2h for all oily wastewater samples.
      Graphical abstract image

      PubDate: 2018-05-29T00:37:00Z
      DOI: 10.1016/j.arabjc.2018.04.018
       
  • Selective conversion of stearic acid into high-added value octadecanedioic
           acid using air and transition metal acetate bromide catalyst: Kinetics,
           pathway and process optimization

    • Authors: Nazmun Sultana; Chandan Guria; Vinod K. Saxena
      Abstract: Publication date: Available online 15 May 2018
      Source:Arabian Journal of Chemistry
      Author(s): Nazmun Sultana, Chandan Guria, Vinod K. Saxena
      Liquid phase selective homogeneous catalytic oxidation of stearic acid (SA) was carried out to obtain industrially important carbon neutral high-added value octadecanedioic acid (ODDA). The oxidation was carried using air, cobalt(II)-acetate, manganese(II)-acetate and HBr catalyst in acetic acid (AcOH) solvent at an elevated temperature and pressure. SA oxidation products were analyzed by gas chromatography–mass spectrometry (GC–MS), gas chromatography (GC) and CO2 analyzer, and SA was oxidized selectively to ODDA without producing CO2 and intermediates like alcohols, aldehydes and ketones. The effect of SA loading (5–20%), pressure (2.8–5.8 barg) and temperature (353–383 K) on ODDA yield was studied by varying one variable at a time. Central composite design assisted response surface methodology was employed to find (i) the optimal design of experiments involving several combination of cobalt(II)-acetate (Co: 0–700 ppm), manganese(II)-acetate (Mn: 0–700 ppm) and HBr (Br–: 0–1144 ppm) and (ii) the most influencing variable and interaction among the variables. The synergistic effect of cobalt(II)-acetate in presence of HBr was observed and suggested that SA oxidation proceeds via bromine-bromide cycle. The elevated temperature and pressure along with reduced SA loading enhanced the yield of ODDA. The maximum ODDA yield was found to be 90.5% and corresponding optimum cobalt (II), manganese (II) and bromide concentration were 600.4, 452.2 and 1016.6 ppm, respectively, at fixed SA:AcOH-10:90, pressure-2.8 barg and temperature-383 K. Finally, SA oxidation kinetic analysis was determined based on the pseudo-first order homogeneous catalysis and found to be kinetically controlled with an average activation energy 34.55 kJ mol−1. The proposed kinetic model fitted well with the time-variant experimental SA and ODDA concentration under varying operating condition with percent average absolute deviation less than 5.0%.

      PubDate: 2018-05-29T00:37:00Z
      DOI: 10.1016/j.arabjc.2018.05.001
       
  • Effects of a dianion compound as a surface modifier on the back reaction
           of photogenerated electrons in TiO2-based solar cells

    • Authors: Ji Young Kim; Ki Hong Kim; Dae-Hwan Kim; Yoon Soo Han
      Abstract: Publication date: Available online 7 May 2018
      Source:Arabian Journal of Chemistry
      Author(s): Ji Young Kim, Ki Hong Kim, Dae-Hwan Kim, Yoon Soo Han
      The TiO2 films were modified with a dianion compound, 1,2-ethanedisulfonic acid disodium salt (ESD), to give a negative charge (ethane sulfonate anion) on the TiO2 surface, i.e., TiO2-O-SO2-CH2-CH2-SO3 -), and effects of repulsion between the negative charge and ions (I3 −) of the electrolyte on the performance of dye-sensitized solar cells (DSSCs) were investigated. The reference device without any modification showed a power conversion efficiency (PCE) of 9.89%, whereas for the device with ESD(20)-TiO2/FTO, which was prepared by soaking bare TiO2/FTO in an ESD solution for 20 min, the PCE was increased to 10.97%, due to an increase in both short-circuit current (Jsc ) and open-circuit voltage(Voc ). It was verified from the measurements of electrochemical impedance, open-circuit voltage decay and dark current that the enhancement in the Jsc and Voc values was attributed to the reduced back reaction between photoinjected electrons and I3 − ions, resulting from the presence of the ethane sulfonate anions on the TiO2 surface.

      PubDate: 2018-05-29T00:37:00Z
      DOI: 10.1016/j.arabjc.2018.04.017
       
  • Influence of the surfactant degree of oligomerization on the formation of
           cyclodextrin:surfactant inclusion complexes

    • Authors: Victoria Isabel Martín; Pilar López-Cornejo; Manuel López-López; Daniel Blanco-Arévalo; Antonio José Moreno-Vargas; Manuel Angulo; André Laschewsky; María Luisa Moyá
      Abstract: Publication date: Available online 5 May 2018
      Source:Arabian Journal of Chemistry
      Author(s): Victoria Isabel Martín, Pilar López-Cornejo, Manuel López-López, Daniel Blanco-Arévalo, Antonio José Moreno-Vargas, Manuel Angulo, André Laschewsky, María Luisa Moyá
      Supramolecular complexation is an attractive strategy to modulate the performance of surfactants, e.g., by host-guest interactions. Here, we investigate the interaction of single-chained, di-, tri-, and tetrameric cationic surfactants with cyclodextrins by conductivity and 1H NMR measurements, exploring the effect of increasing the number of the surfactant hydrophobic tails on the stability of cyclodextrin:surfactant inclusion complexes. The stoichiometry and the binding equilibrium constants of the different inclusion complexes were elucidated. Under the working conditions, the number of hydrophobic chains was found not to affect stoichiometry and 1:1 inclusion complexes were formed for all the surfactants investigated. The stability of the host-guest complexes decreases from single-chained to dimeric (“gemini”) surfactants, the binding following a non-cooperative mechanism. This result may be rationalized by taking into account steric constraints and electrostatic effects as well as the need to overcome the hydrophobic interactions between the chains of the same surfactant molecule. However, a further increase in the number of hydrophobic tails, from two to three to four, results in an increase in the equilibrium binding constant, K1. In this case, an increment in the number of chains capable of interaction with the cyclodextrin molecules seems to be the main factor responsible for the increase in K1. ROESY spectra show the coexistence of different types of 1:1 host-guest complexes for tri- and tetrameric surfactants.
      Graphical abstract image

      PubDate: 2018-05-29T00:37:00Z
      DOI: 10.1016/j.arabjc.2018.04.015
       
  • Effect of functionalization of iron oxide nanoparticles on the physical
           properties of poly (aniline-co-pyrrole) based nanocomposites: Experimental
           and theoretical studies

    • Authors: Ehsan Nazarzadeh Zare; Tahereh Abdollahi; Ahmad Motahari
      Abstract: Publication date: Available online 4 May 2018
      Source:Arabian Journal of Chemistry
      Author(s): Ehsan Nazarzadeh Zare, Tahereh Abdollahi, Ahmad Motahari
      Poly(aniline-co-pyrrole)@functionalized Fe3O4 (PACP@f-Fe3O4) nanocomposites were prepared by a two-step method. In the first step, the Fe3O4-OH and Fe3O4-NH2 nanoparticles were synthesized by the solvothermal and co-precipitation techniques, respectively. In the second step, the PACP@f-Fe3O4 nanocomposites were synthesized by an in-situ microemulsion polymerization technique. The synthesized materials were characterized by Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), scanning electron microscopy (SEM), and thermogravimetric analysis (TGA). Based on the SEM, the iron oxide changed the morphology of the PACP copolymer from being completely nanospheres. The TGA showed the higher thermal stability of the PACP@Fe3O4-OH nanocomposite in comparison to the PACP@Fe3O4-NH2, and the density functional theory (DFT) successfully confirmed this fact by calculating the binding energies between the PACP copolymer and functionalized nanoparticles. Also, the HOMO − LUMO energy gap ( E g ) values were determined by the DFT to investigate the electrical conductivities, which are in accord with the experimental electrical conductivities in the order PACP@Fe3O4-OH > PACP@Fe3O4-NH2 > PACP.

      PubDate: 2018-05-29T00:37:00Z
      DOI: 10.1016/j.arabjc.2018.04.016
       
  • Inside Front Cover - Editorial Board

    • Abstract: Publication date: May 2018
      Source:Arabian Journal of Chemistry, Volume 11, Issue 4


      PubDate: 2018-05-29T00:37:00Z
       
  • Synthesis of CeO2 doped ZnO nanoparticles and their application in
           Zn-composite coating on mild steel

    • Authors: Deepa Kallappa; Venkatesha Thimmappa Venkatarangaiah
      Abstract: Publication date: Available online 27 April 2018
      Source:Arabian Journal of Chemistry
      Author(s): Deepa Kallappa, Venkatesha Thimmappa Venkatarangaiah
      CeO2 doped ZnO nanoparticles were synthesized by co-precipitation method and their size, structure and composition were characterized by XRD, SEM and EDAX analysis. The nanoparticles were used for generation of Zn-CeO2 doped ZnO composite (Zn-composite) coating on mild steel by electroplating. The surface morphology, elemental composition of Zn coated and Zn-composite coated samples were examined by scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDAX) respectively. Corrosion experiments were carried out by electrochemical techniques such as OCP, Tafel polarization, Anodic polarization and electrochemical impedance spectroscopy. The electrochemical corrosion behavior of Zn-composite coating was compared with pure zinc coating. The morphology of the deposits after corrosion tests was analyzed by SEM images. Incorporation of CeO2 doped ZnO nanoparticles into Zn-matrix significantly improved the corrosion resistance property of Zn-coating.

      PubDate: 2018-05-29T00:37:00Z
      DOI: 10.1016/j.arabjc.2018.04.014
       
  • Green biosynthesis of superparamagnetic magnetite Fe3O4 nanoparticles and
           biomedical applications in targeted anticancer drug delivery system: A
           review

    • Authors: Yen Pin Yew; Kamyar Shameli; Mikio Miyake; Nurul Bahiyah Bt Ahmad Khairudin; Shaza Eva Bt Mohamad; Takeru Naiki; Kar Xin Lee
      Abstract: Publication date: Available online 26 April 2018
      Source:Arabian Journal of Chemistry
      Author(s): Yen Pin Yew, Kamyar Shameli, Mikio Miyake, Nurul Bahiyah Bt Ahmad Khairudin, Shaza Eva Bt Mohamad, Takeru Naiki, Kar Xin Lee
      This review discussed about the green biosynthesis of magnetite nanoparticles (Fe3O4-NPs) and the biomedical applications, which mainly focus on the targeted anticancer drug delivery. Fe3O4-NPs have been studied and proved that Fe3O4-NPs can be used in various fields of application, due to “superparamagnetic” property that Fe3O4-NPs possessed. In targeted drug delivery system, drug loaded Fe3O4-NPs can accumulate at the tumor site by the aid of external magnetic field. This can increase the effectiveness of drug release to the tumor site and vanquish cancer cells without harming healthy cells. In order to apply Fe3O4-NPs in human body, Fe3O4-NPs have to be biocompatible and biodegradable to minimize the toxicity. So, green biosynthesis plays a crucial role as the biosynthesized Fe3O4-NPs is safe to be consumed by human because the materials used are from biological routes, such as plant extract and natural polymer. However, biosynthesis using plant extract is the most popular among them all as plant extract can act as both reducing and stabilizing agents in the synthesizing process of nanoparticles. This approach is not merely simple, yet economic and less waste production, which is environmental friendly. Several biomedical applications of Fe3O4-NPs are included in this review, but anticancer drug delivery study is discussed in detail. The criteria for Fe3O4-NPs to be used as drug delivery vehicle are discussed so as to study the optimum condition of Fe3O4-NPs in drug delivery application. Many researches showed the promising results of Fe3O4-NPs in treating cancer cells via in vitro study. Hence, this review is significant which summarize the vital points of Fe3O4-NPs in targeted anticancer drug delivery system. Conclusions have been made according to the literature reviewed and some points of view were proposed for future study.

      PubDate: 2018-05-29T00:37:00Z
      DOI: 10.1016/j.arabjc.2018.04.013
       
  • Unveiling Interactions Between DNA and Cytotoxic
           2-Arylpiperidinyl-1,4-Naphthoquinone Derivatives: A Combined
           Electrochemical and Computational Study

    • Authors: Christian Espinosa-Bustos; Camila Canales; Galo Ramírez; Pablo Jaque; Cristian O. Salas
      Abstract: Publication date: Available online 25 April 2018
      Source:Arabian Journal of Chemistry
      Author(s): Christian Espinosa-Bustos, Camila Canales, Galo Ramírez, Pablo Jaque, Cristian O. Salas
      Three 2-arylpiperidinyl-1,4-naphthoquinone derivatives were synthesized and evaluated in vitro to determine their cytotoxicity on cancer and normal cell lines. In order to establish their possible action mechanism, the electrochemical behaviour of these quinones was examined using cyclic voltammetry (CV) as technique by using a three-electrode setup: a glassy carbon, Ag/AgCl (in 3M KCl), and platinum wire as working, reference, and counter electrodes, respectively. Kinetic studies were done to determine the control of the reduction reaction and the number of transferred electrons in the process. Furthermore, the addition of dsDNA to the quinone solutions allowed for the observation of an interaction between each quinone and dsDNA as the current-peaks became lower in presence of dsDNA. Otherwise, motivated to support the aforementioned results, electronic structure calculations at the TPSS-D3/6-31+G(d,p) level of theory were carried out in order to find the most favourable noncovalently bonded complexes between quinones and DNA. Noncovalent complexes formed between DNA and 2-arylpiperidinyl-1,4-naphthoquinones and stabilized by π-stacking interactions along with the well-known hydrogen-bonded complexes were found, with the former being more stable than the latter. These results suggest that the intercalation of these quinone derivatives in DNA is the most likely action mechanism.

      PubDate: 2018-04-25T14:26:46Z
      DOI: 10.1016/j.arabjc.2018.04.008
       
  • Supramolecular Drug Inclusion Complex of Capecitabine with Cucurbit[7]uril
           and Inverted Cucurbit[7]uril

    • Authors: Hai-Yan Wang; Yang Zhou; Ji-Hong Lu; Qing-Yun Liu; Gui-Ying Chen; Zhu Tao; Xin Xiao
      Abstract: Publication date: Available online 25 April 2018
      Source:Arabian Journal of Chemistry
      Author(s): Hai-Yan Wang, Yang Zhou, Ji-Hong Lu, Qing-Yun Liu, Gui-Ying Chen, Zhu Tao, Xin Xiao
      The interaction of capecitabine (CAP) with cucurbit[7]uril (Q[7]) and inverted cucurbit[7]uril (iQ[7]) was investigated using nuclear magnetic resonance, fluorescence spectroscopy, MALDI-TOF mass spectrometry and isothermal titration calorimetry. The obtained results revealed that the alkyl chain of CAP is located inside the cavities of Q[7] or iQ[7], whereas the other section of CAP remains outside the portal. Our results suggest that both Q[7] and iQ[7] could be promising candidates for excipients used in medicinal and pharmaceutical research fields.
      Graphical abstract image

      PubDate: 2018-04-25T14:26:46Z
      DOI: 10.1016/j.arabjc.2018.04.011
       
  • Anchoring N-Halo (Sodium Dichloroisocyanurate) on the nano-Fe3O4 surface
           as “chlorine reservoir”: antibacterial properties and wastewater
           treatment

    • Authors: Ardeshir Khazaei; Negin Sarmasti; Jaber Yousefi Seyf; Zohreh Merati
      Abstract: Publication date: Available online 25 April 2018
      Source:Arabian Journal of Chemistry
      Author(s): Ardeshir Khazaei, Negin Sarmasti, Jaber Yousefi Seyf, Zohreh Merati
      A novel retrievable bifunctional magnetic nano-structure (sodium dichloroisocyanurate immobilized on the Fe3O4@SiO2@Si(CH2)3Cl surface) was synthesized. Its antibacterial performance as water disinfectant successfully evaluated. The value of Minimum Bactericidal Concentration (625 ppm) and Minimum Inhibitory Concentration (314.5 ppm) show that magnetic nano-structure is a very effective antibacterial structure against the E. coli bacteria. In addition the viability of bacteria (%) was evaluated at different contact time against magnetic nano-structure. The disinfection procedure is very clean without any residual cyanuric acid in water. In other hand, oxidizing performance of nano-structure against the azo dye (acid red-18) was evaluated which attributed to the releasing HOCl in water. Kinetic of dye removal was measured at 0.01, 0.05, 0.1, and 0.5 g of nano-structure. Reducing pH and increasing temperature leads to increased Acid Red 18 degradation. Chemical oxygen demand (COD) measurement shows the effectiveness of nano-structure in acid red-18 degradation. The nano-structure turns to be magnetically retrievable, clean disinfectant, wastewater treatment agent, and its chlorine can be regenerated simply by exposure to household bleach such as Ca(OCl)2.

      PubDate: 2018-04-25T14:26:46Z
      DOI: 10.1016/j.arabjc.2018.04.007
       
  • Nanostructured pH-Responsive Biocompatible Chitosan Coated Copper Oxide
           Nanoparticles: A Polymeric Smart Intracellular Delivery System For
           Doxorubicin In Breast Cancer Cells

    • Authors: Nipun Babu Varukattu; Raju Vivek; Chandrababu Rejeeth; Ramar Thangam; Thondhi Ponraj; Alok Sharma; Soundarapandian Kannan
      Abstract: Publication date: Available online 25 April 2018
      Source:Arabian Journal of Chemistry
      Author(s): Nipun Babu Varukattu, Raju Vivek, Chandrababu Rejeeth, Ramar Thangam, Thondhi Ponraj, Alok Sharma, Soundarapandian Kannan
      In this study, we report a novel feasible single step reduction method for the active synthesis of biocompatible chitosan coated copper oxide nanoparticles (Cs-CuO NPs), for loading and delivery of doxorubicin (DOX) into breast cancer cells. The formulated nanoparticles (NPs) were characterized by size, shape and surface charge using various sophisticated instruments. Interestingly, these formulated particles showed profound drug loading activity and also showed its versatile nature of DOX release at different pH which makes them as ideal particles for breast cancer therapy. Intracellular uptake was evaluated through fluorescence microscopy studies with the help of coumarin. Morphological and apoptotic studies with the DOX-Cs-CuO NPs on MCF-7 cells showed its ability to induce apoptosis in breast cancer cells, which was clearly substantiated by ROS generation with the loss of mitochondrial membrane potential. Our results clearly showed the therapeutic nature of novel biocompatible Cs-CuO NPs in delivering DOX with a pH-dependent manner.

      PubDate: 2018-04-25T14:26:46Z
      DOI: 10.1016/j.arabjc.2018.04.012
       
  • Low-loading of oxidized platinum nanoparticles into mesoporous titanium
           dioxide for effective and durable hydrogen evolution in acidic media

    • Authors: Mabrook S. Amer; Mohamed A. Ghanem; Abdullah M. Al-Mayouf; Prabhakarn Arunachalam; Nezar H. Khdary
      Abstract: Publication date: Available online 25 April 2018
      Source:Arabian Journal of Chemistry
      Author(s): Mabrook S. Amer, Mohamed A. Ghanem, Abdullah M. Al-Mayouf, Prabhakarn Arunachalam, Nezar H. Khdary
      Low-loading of oxidized platinum nanoparticles (0.1 – 0.5 wt.%) was incorporated into mesoporous titanium dioxide support (Ptx/meso-TiO2) via evaporation self-assembly (ESA) approach followed by a two-step calcination processes. The physicochemical characterizations showed that the oxidized Ptx/meso-TiO2 catalysts exhibit high surface area around 200 m2/g and Pt nanoparticles having an average size of 3.0 nm are uniformly incorporated into the mesoporous TiO2 matrix with the existence of Pt(II) and Pt(IV) oxidation states. The Ptx/meso-TiO2 electrocatalysts showed an enhanced electrocatalytic activity with hydrogen evolution onset potential at −10 mV vs. RHE, Tafel slope of −110 mV/dec, small charge transfer resistance, and mass activity that reaches up to 25.7 A/mgPt at −300 mV vs. RHE. The hydrogen evolution mass activity of Ptx/meso-TiO2 electrocatalysts is significantly more efficient than the commercial Pt/C catalysts and Pt nanoparticles supported on nanostructured carbon substrates. Moreover, the Ptx/meso-TiO2 electrocatalysts exhibit excellent durability for a 24-hour electrolysis in acid solution with a further current activation during the prolonged electrolysis. The enhanced mass activity and durability are attributed to the substrate mesoporosity, uniform distribution and strong bonding between the oxidized Pt nanoparticles and the TiO2 substrate. These results demonstrate the promise of the mesoporous TiO2 substrate modified with low loading of platinum nanoparticles for energy conversion technologies.

      PubDate: 2018-04-25T14:26:46Z
      DOI: 10.1016/j.arabjc.2018.04.010
       
  • Integration of Virtual Screening and Computational Simulation Identifies
           Photodynamic Therapeutics against Human Protoporphyrinogen Oxidase IX
           (hPPO)

    • Authors: Amir Zeb; Chanin Park; Minky Son; Ayoung Baek; Yeongrae Cho; Donghwan Kim; Shailima Rampogu; Gihwan Lee; Youn-Sig Kwak; Seok Ju Park; Keun Woo Lee
      Abstract: Publication date: Available online 25 April 2018
      Source:Arabian Journal of Chemistry
      Author(s): Amir Zeb, Chanin Park, Minky Son, Ayoung Baek, Yeongrae Cho, Donghwan Kim, Shailima Rampogu, Gihwan Lee, Youn-Sig Kwak, Seok Ju Park, Keun Woo Lee
      Photodynamic therapy (PDT) is a rapidly evolving area of cancer management against solid tumors. PDT is either administrated by injecting photosensitizer (porphyrins) or by accumulation of intracellular protoporphyrin IX via the inhibition of human Protoporphyrinogen Oxidase IX (hPPO). In this study, novel inhibitors of hPPO have been investigated by integrating virtual screening, molecular docking, and molecular dynamics (MD) simulation. A ligand-based pharmacophore was generated from a training set of 22 inhibitors of hPPO. The selected pharmacophore had four chemical features including three hydrogen bond acceptors and one hydrophobic. The pharmacophore was characterized by highest correlation coefficient of 0.97, cost difference of 53.20, and lowest root mean square deviation of 0.73. The resultant pharmacophore was validated by Fischer’s Randomization and Test Set Validation methods. The validated pharmacophore was used as a 3D query to screen chemical databases including NCI, Asinex, Chembridge, and Maybridge. The screening of chemical databases and the subsequent application of Lipinski’s Rule of Five, and ADMET Assessment Test, retrieved 1176 drug-like compounds. The drug-like compounds were subjected to molecular docking studies in the active site of hPPO to eliminate false positive hits and to elucidate their true binding orientation. Top three candidate molecules with high docking scores and hydrogen bond interactions with catalytic active residues were selected as best best candidate molecules against hPPO inhibitors. The binding stability of selected candidate molecules was evaluated by MD simulation. The MD simulation of hits portrayed strong hydrogen bonds and key hydrophobic interactions with catalytic active residues of hPPO including R59, R97, G159, G332 and flavin moiety of FAD (coenzyme of hPPO). Our study predicts three hit compounds against hPPO, which could possibly accumulate high concentration of protoporphyrinogen-IX, and thereby acting as an intracellular photosensitizer against tumor cells through photodynamic therapy.

      PubDate: 2018-04-25T14:26:46Z
      DOI: 10.1016/j.arabjc.2018.04.009
       
  • Impact of annealing on the structural and optical properties of ZnO
           nanoparticles and tracing the formation of clusters via DFT calculation

    • Authors: Rezq Naji Aljawfi; Moh Jane Alam; F. Rahman; Shabbir Ahmad; Aga Shahee; Shalendra Kumar
      Abstract: Publication date: Available online 22 April 2018
      Source:Arabian Journal of Chemistry
      Author(s): Rezq Naji Aljawfi, Moh Jane Alam, F. Rahman, Shabbir Ahmad, Aga Shahee, Shalendra Kumar
      In this report, nanoparticles (NPs) of zinc oxide (ZnO) were synthesized through auto-combustion route and annealed in air at different temperatures: 200, 400, 600 and 800 °C. The single phase nature has been confirmed via X-ray diffraction (XRD) and selected area electron diffraction (SAED) analysis. The average of crystallite sizes increased progressively as the thermal annealing increase and ranging between 13.8 and 39.7 nm. Raman spectra resembled to that of hexagonal ZnO wurtzite structure, the narrowing in E2H (438 cm-1) Raman phonon mode in sequence with further annealing indicates improvement in the crystallinity and reduction in the local atomic defects of oxygen vacancy (Vo2+). The defects create energy deep bands within the band gap region and diminish the UV emission efficiency that has been assessed through photoluminescence (PL) spectroscopic. The donor band of oxygen vacancy (Vo2+) was ∼ 1 eV above valence band (VB), whereas the acceptor band of zinc vacancy (VZn 2-) was at ∼ 0.85 eV above the VB. The ZnO NPs that was annealed at lowest temperature of 200 °C exhibited different behavior trend in which the UV-PL band was diminished clearly, blue shifted to lower wave length and appeared as small plateau at the range of 380-270 nm corresponding to high band gap energy (3.8-4.6 eV), which is indicative to low crystal quality and presence of clusters. We used density function theory (DFT) calculation for computing the HOMO-LUMO band gap of supposed clusters ZnnOn (n=2, 3, 5, 10). The high band gap energy of the simulated clusters was agreed with that of ZnO NPs annealed at 200 °C that gives indirect evidence on the formation of clusters.

      PubDate: 2018-04-25T14:26:46Z
      DOI: 10.1016/j.arabjc.2018.04.006
       
  • Acetocatechol functionalized viologen as polyfunctional material that
           responds to anion, cation and reductant in aqueous and organic solvents

    • Authors: Huanhuan Qiao; Yue-Ling Bai; Yongmei Zhao; Feifei Xing; Ming-Xing Li; Shourong Zhu
      Abstract: Publication date: Available online 17 April 2018
      Source:Arabian Journal of Chemistry
      Author(s): Huanhuan Qiao, Yue-Ling Bai, Yongmei Zhao, Feifei Xing, Ming-Xing Li, Shourong Zhu
      Both viologen and catechol have been studied extensively. However, the stability of catechol-Fe(III) without additional oxidant is still not well understood. In this paper, we introduced acetocatechol into viologen to investigate its interactions with anion, cation, and reductant, as well as the stability of its Fe(III) complexes. This acetocatechol functionalized viologen, 1,1'-bis(2-(3,4-dihydroxyphenyl)-2-oxoethyl)- [4,4'-bipyridine]-1,1'-diium chloride (H6V·Cl2) exists in central symmetric ketone cation form in solid state. Viologen cation increased the acidity of the aceto group and deprotonated the enolic proton to form monodeprotonated enolic H5V+ in the presence of anion/base, which had the deepest color in organic solvents. The absorbance maximum of H5V+ increased with the decrease of solvent polarity. It also interacted with B4O7 2- and MoO4 2- by forming catechol ester in DMSO solution. The catechol moiety can coordinate to metal ion, especially Fe(III), in both aqueous and DMSO solution. In particular, it coordinated to Fe(III) much more readily in aqueous solution than in DMSO. Green monocatecholato Fe(III) and red-brown bis-catecholato Fe(III) complex also formed in aqueous solution. The monocatecholato Fe(III) complex first-order dimerized in aqueous solution at room temperature but underwent second-order decomposition to Fe(II) complex at 60°C. The biscatecholato Fe(III) complex also transferred to other Fe(III) complexes at first- and second-order at room-temperature and 60 °C respectively. The t1/2 varied from several hours at room-temperature and several minutes at 60 °C at 10-4 M concentration. The interactions of Fe(III) in DMSO is much more complex than that of acetocatecholate without viologen. Fe(III) can also be reduced to free viologen radicals in the presence of sodium Na2S2O4, but not N2H4. In conclusion, this polyfunctional compound responds to anion via aceto and catechol, metal ion via catechol hydroxyl, while reductant via viologen.
      Graphical abstract image

      PubDate: 2018-04-25T14:26:46Z
      DOI: 10.1016/j.arabjc.2018.04.005
       
  • Microparticles based on carboxymethyl starch/chitosan polyelectrolyte
           complex as vehicles for drug delivery systems

    • Authors: Rafael F.N. Quadrado; André R. Fajardo
      Abstract: Publication date: Available online 16 April 2018
      Source:Arabian Journal of Chemistry
      Author(s): Rafael F.N. Quadrado, André R. Fajardo
      Microparticles with oval-shape morphology and rough and porous surfaces were prepared by polyelectrolyte complexation of carboxymethyl starch (CMS) and chitosan (Cs). CMS with DS of 0.5, the polyanionic moiety, was synthesized from rice starch with low content of amylose (6%). A preliminary investigation revealed that this kind of starch is more susceptive to esterification than rice starches with higher contents of amylose. The CMS/Cs microparticles showed higher chemical and thermal stability than microparticles prepared by conventional ionotropic crosslinking of Cs with TPP ions. The carboxymethyl groups of CMS are more efficient to neutralize the positive groups of Cs and, also, enhance the entrapment of bovine serum albumin (BSA) in the CMS/Cs matrix as compared to Cs/TPP. In vitro experiments conducted in simulated gastric fluid (pH 1.2) and simulated intestinal fluid (pH 6.8) with the testing microparticles revealed that the CMS/Cs-BSA microparticles exhibit a highlighted pH-dependent release profile. This desirable property allows controlling the release of BSA more efficiently, which minimizes undesirable issues (e.g. burst effect and non-sustained release). Furthermore, the BSA release from CMS/Cs-BSA microparticles in SIF follows an ideal Zero-order kinetics, which is very attractive for a drug delivery system. Therefore, microparticles based on CMS/Cs polyelectrolyte complex may be promising to control the drug release in specific regions of the gastrointestinal tract.
      Graphical abstract image

      PubDate: 2018-04-25T14:26:46Z
      DOI: 10.1016/j.arabjc.2018.04.004
       
  • Porous multifunctional fluoropolymer composite foams prepared via humic
           acid modified Fe3O4 Nanoparticles stabilized Pickering high internal phase
           emulsion using cationic fluorosurfactant as co-stabilizer

    • Authors: Umair Azhar; Chenxi Huyan; Xiaozheng Wan; Chuanyong Zong; Anhou Xu; Jitao Liu; Jiachen Ma; Shuxiang Zhang; Bing Geng
      Abstract: Publication date: Available online 14 April 2018
      Source:Arabian Journal of Chemistry
      Author(s): Umair Azhar, Chenxi Huyan, Xiaozheng Wan, Chuanyong Zong, Anhou Xu, Jitao Liu, Jiachen Ma, Shuxiang Zhang, Bing Geng
      Fluoropolymers are very important owing to their excellent application performances, especially in extreme conditions. On the other hand, the preparation of porous fluoropolymers is a difficult task due to unavailability of suitable surfactants as well as tedious synthesis steps. Here we prepared multifunctional porous fluoropolymer composite foams with a simple process of “high internal phase emulsion (HIPE)” by using humic acid modified iron oxide nanoparticles (HA-Fe3O4 NPs) and cationic fluorosurfactant (CFS) (PDMAEMA-b-PHFBA) as co-stabilizer. The inclusion of HA-Fe3O4 NPs in the system made fluoro-HIPE more stable than the emulsion prepared using only CFS or other conventional stabilizers. Morphology of the prepared polyHIPE was easily controlled by altering the concentration of HA-Fe3O4 and/or CFS in the original formulation. Adjustment of the porous structure with open/close cells was performed and the average diameter of the pores tuned between 4.9-23 μm. With the increase in specific surface area by using nanoparticles (NPs) and CFS as co-surfactants, Pickering HIPE monoliths adsorbed double amount of oil compared to foams based solely on HIPE template. Multiple functional groups were bound onto Fe3O4 NPs through HA modification that made the fluoro-monolith capable of adsorbing dye, i.e. methylene blue, from water. A simple centrifugation enabled regeneration of the oil soaked foams and adsorption capacity was not decreased after 10 adsorption/regeneration cycles.

      PubDate: 2018-04-25T14:26:46Z
      DOI: 10.1016/j.arabjc.2018.04.003
       
  • Hierarchical nanocrystalline NiO with coral-like structure derived from
           nickel galactarate dihydrate: An active mesoporous catalyst for methyl
           ethyl ketone production

    • Authors: Samih A. Halawy; Mohamed A. Mohamed; Adel Abdelkader
      Abstract: Publication date: Available online 14 April 2018
      Source:Arabian Journal of Chemistry
      Author(s): Samih A. Halawy, Mohamed A. Mohamed, Adel Abdelkader
      Nanocrystalline NiO with a coral-like structure (38 nm) has been prepared via thermal decomposition of a new precursor, nickel galactarate (NiC6H8O8·2H2O), at 500 °C for 3 h in air. Thermal decomposition of that precursor was studied by TG and DSC techniques. The resultant NiO was physicochemically characterized by XRD, FTIR, SEM, surface area, porosity and CO2-TPD. NiO was found to exhibit a remarkable activity towards the synthesis of MEK from 2-butanol between 200 and 325 °C. In addition, it has shown a great tendency to ease regeneration of the used catalyst after 192 h in stream by simple refreshing method.

      PubDate: 2018-04-25T14:26:46Z
      DOI: 10.1016/j.arabjc.2018.03.023
       
  • Analysis of amphetaminic drug compounds in urine by headspace-dielectric
           barrier discharge ionization-mass spectrometry

    • Authors: Ahsan Habib; Aklima Nargis; Lei Bi; Peng Zhao; Wen Luhong
      Abstract: Publication date: Available online 11 April 2018
      Source:Arabian Journal of Chemistry
      Author(s): Ahsan Habib, Aklima Nargis, Lei Bi, Peng Zhao, Wen Luhong
      Rapid detection of trace level amphetaminic drug compounds in urine is essential to monitor consumption of these abuse drugs by athletes. In this work, the amphetaminic drug compounds were spiked in human urine and analyzed using headspace - dielectric barrier discharge (DBD) ionization-mass spectrometry method. In the headspace method, the urine spiked drug compound was treated with alkali solution, thus the free base amphetaminic molecules were released into the gas phase. The gaseous molecules were then ionized by the DBD ion source placed in front of the mass spectrometer inlet under ambient condition. This method provided comparable sensitivity with the solid-phase microextraction (SPME) in analysis of the amphetaminic compounds where no derivatization or adduct formation was required. The present method also facilitated the sensitivity enhancement with about one order of magnitude in urine compared to standard solution. Carbonate alkali solution showed the highest sensitivity for detection of the drug compounds in urine and the sensitivity was enhanced by using NH3. The limits of detection (LODs) of the various amphetaminic molecules were found to be in the range of 0.10-0.80 ng/mL for standard solutions while those for urine were in the range of 0.04-0.40 ng/mL. The analytical figures of merit of this method were evaluated under ambient condition using suitable internal standard. Results suggested the suitability of this method for analytical routine work in detection of amine-based drugs in doping test and/or in forensic laboratories. A mechanism of enhanced sensitivity by the ammoniated carbonate alkali solution in urine is also discussed.

      PubDate: 2018-04-25T14:26:46Z
      DOI: 10.1016/j.arabjc.2018.04.001
       
  • Aloe-vera flower shaped rutile TiO2 for selective hydrogenation of
           nitroaromatics under direct sunlight irradiation

    • Authors: Satnam Singh; Roopchand Prajapat; Rayees Ahmad Rather; Bonamali Pal
      Abstract: Publication date: Available online 10 April 2018
      Source:Arabian Journal of Chemistry
      Author(s): Satnam Singh, Roopchand Prajapat, Rayees Ahmad Rather, Bonamali Pal
      This study reveals the fabrication of a sunlight receptive flower shaped rutile TiO2 microstructure (F-TiO2) for the selective photoreduction of nitroaromatics. The crystalline F-TiO2 possesses small band gap (∼2.8 eV) and large specific surface area (193 m2g−1). Moreover, the F-TiO2 exhibited higher relaxation time (120 µs) for the electron-hole pairs due to its brilliant multi dimensional morphology that enables shorter diffusion path and multiple scattering of active sites. The experimental results revealed the superior photocatalytic activity of the F-TiO2 microstructure in contrast to active P25 and rutile TiO2 (obtained from thermally treated P25 at 800 °C for 4 h) for the reduction of nitrobenzene, m-dinitrobenzene and 2,2-dinitrobiphenyl in 50% aqueous isopropanol (hole scavenger) to aniline (42–72%), m-nitroaniline (37–42%), m-phenylenediamine (88–100%) and benzo[c]cinnoline (80–94%) respectively under UV and direct sunlight irradiation. The quantitative estimation of byproducts like acetone and hydrogen (H2) produced from iso-propanol oxidation and water splitting during instant reduction of nitroaromatics to aromatic amines is well correlated and explained on the basis of its beneficial surface structural and electronic properties.
      Graphical abstract image

      PubDate: 2018-04-25T14:26:46Z
      DOI: 10.1016/j.arabjc.2018.04.002
       
  • In vitro and in vivo characterization of mineralized
           hydroxyapatite/polycaprolactone-graphene oxide based bioactive
           multifunctional coating on Ti alloy for bone implant applications

    • Authors: Nagaraj Murugan; Chandran Murugan; Ashok K. Sundramoorthy
      Abstract: Publication date: Available online 5 April 2018
      Source:Arabian Journal of Chemistry
      Author(s): Nagaraj Murugan, Chandran Murugan, Ashok K. Sundramoorthy
      Hydroxyapatite (HAP) is a form of naturally occurring calcium apatite present in bone and tooth enamel. It is an important biomaterial with diverse biomedical applications such as a surface coating for metallic orthopedic implants. Synthesized pristine HAP has poor mechanical properties, inferior wear resistance and has limits for directly used in bone tissue engineering applications. To address these limitations, we synthesized a suitable orthopedic implant hybrid material (M-HAP/PCL/GO) by using positively charged calcium ions of mineralized HAP (M-HAP) combined with Polycaprolactone-negatively charged graphene oxide (PCL-GO). The successfully synthesized M-HAP/PCL/GO composite was comprehensively characterized by Fourier-transform infrared spectroscopy (FT-IR), powder X-ray diffraction (XRD) and field-emission scanning electron microscopy (FE-SEM). The micro-hardness technique was used to determine the mechanical strength of M-HAP (315 ± 4 Hv), M-HAP/GO (370 ± 3 Hv) and M-HAP/PCL/GO (455 ± 5 Hv). M-HAP/PCL/GO was also tested for its anti-bactericidal impact against Staphylococcus aureus and Escherichia coli. MG63 osteoblast cells cultured on the M-HAP/PCL/GO composite (10 mg/mL) coated sample, displayed outstanding viability after 3 and 5 days of incubation at pH 7.4, which indicated that the composite is suitable material for bone implants and induces the cell proliferation. It was also tested in vivo in Wistar rats and was observably beneficial bone formation within 28 days post-implant operation. These tests proved that the M-HAP/PCL/GO composite can be considered as a prospective candidate for future bone implant applications.
      Graphical abstract image

      PubDate: 2018-04-25T14:26:46Z
      DOI: 10.1016/j.arabjc.2018.03.020
       
  • Ag2O nanoparticles/MnCO3, –MnO2 or –Mn2O3/highly reduced graphene
           oxide composites as an efficient and recyclable oxidation catalyst

    • Authors: Mohamed E. Assal; Mohammed Rafi Shaik; Mufsir Kuniyil; Mujeeb Khan; Abdulrahman Al-Warthan; Abdulrahman Ibrahim Alharthi; Ravi Varala; Mohammed Rafiq H. Siddiqui; Syed Farooq Adil
      Abstract: Publication date: Available online 5 April 2018
      Source:Arabian Journal of Chemistry
      Author(s): Mohamed E. Assal, Mohammed Rafi Shaik, Mufsir Kuniyil, Mujeeb Khan, Abdulrahman Al-Warthan, Abdulrahman Ibrahim Alharthi, Ravi Varala, Mohammed Rafiq H. Siddiqui, Syed Farooq Adil
      Silver oxide nanoparticles doped manganese (IV) oxide along with varying percentages of highly reduced graphene oxide (HRG) [Ag2O(1%)–MnO2/(X%)HRG] nanocomposites were fabricated through a simple co-precipitation method followed by calcination at 400 °C. The as-prepared nanocomposite upon calcination at 300 °C and 500 °C temperatures, yields the manganese carbonate (MnCO3) and manganese (III) oxide (Mn2O3) composites i.e. Ag2O(1%)–MnCO3/(X%)HRG and Ag2O(1%)–Mn2O3/(X%)HRG, correspondingly. The structural composition of the prepared nanocomposites has confirmed by several characterization techniques. The nanocomposites have successfully utilized as a catalyst for liquid-phase oxidation of aromatic alcohols in presence of O2 as a green oxidant under alkali-free conditions. In addition, a comparative study was performed to assess the activity of the manganese carbonates and manganese oxides for aerial oxidation of benzyl alcohol into benzaldehyde as a model reaction. Effects of various parameters have thoroughly examined in detail and the Ag2O(1%)–MnO2/(5%)HRG catalyst exhibited the highest activity in the aerial oxidation of benzyl alcohol to benzaldehyde with a 100% conversion and >99% selectivity in a remarkably short reaction time (35 min) than the undoped precursor i.e. Ag2O(1%)–MnO2. The presence of HRG dopant greatly enhanced the catalytic performance of Ag2O–MnO2 nanocatalysts could be attributed to the presence of carbon vacancies and topological defects as well as oxygen carrying functionalities on the HRG surface and increase in the surface area. The as-prepared catalyst could be efficiently recycled and reused up to five times without a discernible drop in its catalytic performance and the product selectivity remained unchanged. The prepared catalyst i.e. Ag2O(1%)–MnO2/(5%)HRG was employed as oxidation catalyst for a series of various substituted benzylic and aliphatic alcohols into their respective aldehydes and yielded complete conversion with excellent product selectivity with no further oxidation to acids.

      PubDate: 2018-04-25T14:26:46Z
      DOI: 10.1016/j.arabjc.2018.03.021
       
  • Tailored surface silica nanoparticles for blood-brain barrier penetration:
           Preparation and in vivo investigation

    • Authors: B.I. Tamba; V. Streinu; G. Foltea; A.N. Neagu; G. Dodi; M. Zlei; A. Tijani; C. Stefanescu
      Abstract: Publication date: Available online 5 April 2018
      Source:Arabian Journal of Chemistry
      Author(s): B.I. Tamba, V. Streinu, G. Foltea, A.N. Neagu, G. Dodi, M. Zlei, A. Tijani, C. Stefanescu
      Surface modified fluorescent silica nanoparticle derivatives (Ru@SNPs), namely, glucose (Glu) and glucose-poly (ethylene glycol) methyl ether amine (Glu-PEG) coated SNPs were designed and tested for their ability to penetrate the blood-brain barrier (BBB) in mice brain. The new obtained nanoparticles were characterized by field emission scanning electron microscope (FE-SEM), dynamic light scattering (DLS) and Fourier transform infrared (FTIR-ATR) analysis. The BBB penetration and distribution of tailored SNPs in mice brain were examined using confocal laser scanning microscopy (CLSM), flow cytometer (FACS) and transmission electron microscopy (TEM). The promising results obtained by in vivo experiments, point out that silica nanoparticle derivatives are an efficient permeable delivery vehicle that are able to cross the BBB and reach the brain tissues via specific and non-specific mechanisms. These findings will enrich the knowledge to rationally engineer multifunctional nanoparticles, and bring new insights into BBB permeability.
      Graphical abstract image

      PubDate: 2018-04-25T14:26:46Z
      DOI: 10.1016/j.arabjc.2018.03.019
       
  • A novel and convenient oxidation-controlled procedure for the synthesis of
           oxazolines from TosMIC and aldehydes in water – Anti biofilm activity

    • Authors: Rajan Abraham; Periakaruppan Prakash; Karthikeyan Mahendran; Murugappan Ramanathan
      Abstract: Publication date: Available online 5 April 2018
      Source:Arabian Journal of Chemistry
      Author(s): Rajan Abraham, Periakaruppan Prakash, Karthikeyan Mahendran, Murugappan Ramanathan
      A new convenient procedure for the synthesis of oxazolines from tosylmethyl isocyanide (TosMIC) and aldehydes using imidazole as an efficient catalyst has been reported. The synthesized oxazolines were able to be protected from the oxidation by using just water both as a good solvent and anti oxidant. All the synthesized compounds show good anti biofilm activity against Staphylococcus epidermidis.
      Graphical abstract image

      PubDate: 2018-04-25T14:26:46Z
      DOI: 10.1016/j.arabjc.2018.03.022
       
  • Design, synthesis, molecular properties and in vitro antioxidant and
           antibacterial potential of novel enantiopure isoxazolidine derivatives

    • Authors: Siwar Ghannay; Sana Bakari; Moncef Msaddek; Sébastien Vidal; Adel Kadri; Kaïss Aouadi
      Abstract: Publication date: Available online 3 April 2018
      Source:Arabian Journal of Chemistry
      Author(s): Siwar Ghannay, Sana Bakari, Moncef Msaddek, Sébastien Vidal, Adel Kadri, Kaïss Aouadi
      A novel series of enantiopure isoxazolidines have been synthesized in good yields and with high stereoselectivity by 1,3-dipolar cycloaddition between a (–)-menthone-derived nitrone as a glycine equivalent and various terminal alkenes. The structures and the stereochemistry of the obtained cycloadducts have been determined by spectroscopic methods. Almost all the compounds were predicted to exhibit various degrees of antioxidant and antibacterial potentiality. Finally, the drug likeness and bioactivity were calculated using Molinspiration software. The results indicated that all compounds are in accordance with Lipinski’s rule of five showing good drug likeness and bioactivity score for drug targets with no violations.
      Graphical abstract image

      PubDate: 2018-04-25T14:26:46Z
      DOI: 10.1016/j.arabjc.2018.03.013
       
  • Electrochemical detection of dihydronicotinamide adenine dinucleotide
           using Al2O3-GO nanocomposite modified electrode

    • Authors: Moataz M. Mekawy; Rabeay Y.A. Hassan; Pankaj Ramnani; Xuejun Yu; Ashok Mulchandani
      Abstract: Publication date: Available online 31 March 2018
      Source:Arabian Journal of Chemistry
      Author(s): Moataz M. Mekawy, Rabeay Y.A. Hassan, Pankaj Ramnani, Xuejun Yu, Ashok Mulchandani
      NADH plays a vital role in the electron transfer processes between metabolites in the cellular energetic reactions. Therefore, there is a crucial need to develop analytical techniques for detecting NADH levels with the metabolism of glucose. In the present study, a nanocomposite of alumina (Al2O3) nanoparticles confined graphene oxide (GO) sheet acts as a modifier for carbon paste electrode (CPE) for a sensitive detection of NADH level in a mediator-less detection scheme. Our findings after optimization of experimental conditions reveal that, there is a remarkable enhancement in the direct electron transfer through the Al2O3-GO nanocomposite surface with high electrocatalytic activity towards NADH oxidation. Results show that, there is a linear increase in NADH detection from 30 µM to 330 µM, together with linear regression coefficient of 0.98 and LOD 4.5 µM. These results confirm that, the developed Al2O3-GO based CPE electrode is a promising electrode for real NADH level detection in practical enzymatic applicability.

      PubDate: 2018-04-25T14:26:46Z
      DOI: 10.1016/j.arabjc.2018.03.017
       
  • Unveiling an unexpected potential of beetroot waste in green synthesis of
           single crystalline gold nanoplates: A mechanistic study

    • Authors: Girish K. Deokar; Arun G. Ingale
      Abstract: Publication date: Available online 31 March 2018
      Source:Arabian Journal of Chemistry
      Author(s): Girish K. Deokar, Arun G. Ingale
      A novel green synthetic route developed toward unveiling a mechanism of formation of single crystalline gold (Au) nanoplates, with a flat surface using an aqueous extract of red beetroot waste (BRW) i.e. peel, at room temperature, the first time. The green method monitored using UV–VIS spectrophotometry, the presence of metallic gold, its structure; orientation and the responsible biomolecules; for reduction validated using EDS, XPS, XRD and FTIR spectroscopies respectively. Based on these significant characterizations, a probable three-step mechanism proposed here for nanoplate synthesis. First, the synthesis of the nanosphere, second its transformation into icosahedrons and ultimately its fragmentation into triangular nanoplates. The green synthetic mechanism for these nanoplates is investigated, validated and evidenced by both HR-TEM and XRD studies. The selected area electron diffraction (SAED) patterns and the assessment of Moire’ fringes confirmed that the nanoplates formed in this manner found single crystalline efficiently oriented in {1 1 1} lattice plane as their basal planes.
      Graphical abstract image

      PubDate: 2018-04-25T14:26:46Z
      DOI: 10.1016/j.arabjc.2018.03.016
       
 
 
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