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  Subjects -> PSYCHOLOGY (Total: 873 journals)
Showing 1 - 174 of 174 Journals sorted alphabetically
Acción Psicológica     Open Access   (Followers: 2)
Acta Colombiana de Psicología     Open Access   (Followers: 4)
Acta Comportamentalia     Open Access   (Followers: 3)
Acta de Investigación Psicológica     Open Access   (Followers: 2)
Acta Psychologica     Hybrid Journal   (Followers: 22)
Activités     Open Access   (Followers: 1)
Actualidades en Psicologia     Open Access   (Followers: 1)
Ad verba Liberorum : Journal of Linguistics & Pedagogy & Psychology     Open Access   (Followers: 8)
Addictive Behaviors Reports     Open Access   (Followers: 5)
ADHD Attention Deficit and Hyperactivity Disorders     Hybrid Journal   (Followers: 20)
ADHD Report The     Full-text available via subscription   (Followers: 6)
Advances in Experimental Social Psychology     Full-text available via subscription   (Followers: 40)
Advances in Mental Health     Hybrid Journal   (Followers: 69)
Advances in Physiotherapy     Hybrid Journal   (Followers: 51)
Advances in Psychology     Full-text available via subscription   (Followers: 58)
Advances in the Study of Behavior     Full-text available via subscription   (Followers: 29)
African Journal of Cross-Cultural Psychology and Sport Facilitation     Full-text available via subscription   (Followers: 3)
Aggression and Violent Behavior     Hybrid Journal   (Followers: 394)
Aggressive Behavior     Hybrid Journal   (Followers: 15)
Aging, Neuropsychology, and Cognition     Hybrid Journal   (Followers: 33)
Ágora - studies in psychoanalytic theory     Open Access   (Followers: 3)
Aletheia     Open Access   (Followers: 1)
American Behavioral Scientist     Hybrid Journal   (Followers: 15)
American Imago     Full-text available via subscription   (Followers: 3)
American Journal of Applied Psychology     Open Access   (Followers: 34)
American Journal of Community Psychology     Hybrid Journal   (Followers: 24)
American Journal of Health Behavior     Full-text available via subscription   (Followers: 23)
American Journal of Orthopsychiatry     Hybrid Journal   (Followers: 4)
American Journal of Psychoanalysis     Hybrid Journal   (Followers: 21)
American Psychologist     Full-text available via subscription   (Followers: 172)
Anales de Psicología     Open Access   (Followers: 2)
Análise Psicológica     Open Access   (Followers: 1)
Análisis y Modificación de Conducta     Open Access   (Followers: 2)
Analysis     Full-text available via subscription   (Followers: 4)
Annual Review of Clinical Psychology     Full-text available via subscription   (Followers: 66)
Annual Review of Organizational Psychology and Organizational Behavior     Full-text available via subscription   (Followers: 27)
Annual Review of Psychology     Full-text available via subscription   (Followers: 211)
Anuario de Psicología / The UB Journal of Psychology     Open Access   (Followers: 1)
Anuario de Psicología Jurídica     Open Access   (Followers: 1)
Anxiety, Stress & Coping: An International Journal     Hybrid Journal   (Followers: 22)
Applied and Preventive Psychology     Hybrid Journal   (Followers: 13)
Applied Cognitive Psychology     Hybrid Journal   (Followers: 67)
Applied Neuropsychology : Adult     Hybrid Journal   (Followers: 32)
Applied Neuropsychology : Child     Hybrid Journal   (Followers: 18)
Applied Psychological Measurement     Hybrid Journal   (Followers: 17)
Applied Psychology     Hybrid Journal   (Followers: 137)
Applied Psychology: Health and Well-Being     Hybrid Journal   (Followers: 48)
Applied Psychophysiology and Biofeedback     Hybrid Journal   (Followers: 7)
Archive for the Psychology of Religion / Archiv für Religionspychologie     Hybrid Journal   (Followers: 17)
Archives of Clinical Neuropsychology     Hybrid Journal   (Followers: 27)
Archives of Scientific Psychology     Open Access   (Followers: 4)
Arquivos Brasileiros de Psicologia     Open Access   (Followers: 1)
Asia Pacific Journal of Counselling and Psychotherapy     Hybrid Journal   (Followers: 8)
Asia-Pacific Psychiatry     Hybrid Journal   (Followers: 3)
Asian American Journal of Psychology     Full-text available via subscription   (Followers: 5)
Asian Journal of Business Ethics     Hybrid Journal   (Followers: 7)
Assessment     Hybrid Journal   (Followers: 10)
At-Tajdid : Jurnal Ilmu Tarbiyah     Open Access   (Followers: 2)
Attachment: New Directions in Psychotherapy and Relational Psychoanalysis     Full-text available via subscription   (Followers: 16)
Attention, Perception & Psychophysics     Full-text available via subscription   (Followers: 10)
Australian and Aotearoa New Zealand Psychodrama Association Journal     Full-text available via subscription  
Australian Educational and Developmental Psychologist, The     Full-text available via subscription   (Followers: 6)
Australian Journal of Psychology     Hybrid Journal   (Followers: 17)
Australian Psychologist     Hybrid Journal   (Followers: 11)
Autism Research     Hybrid Journal   (Followers: 31)
Autism Research and Treatment     Open Access   (Followers: 29)
Autism's Own     Open Access  
Autism-Open Access     Open Access   (Followers: 5)
Avaliação Psicológica     Open Access  
Avances en Psicologia Latinoamericana     Open Access   (Followers: 1)
Aviation Psychology and Applied Human Factors     Hybrid Journal   (Followers: 19)
Balint Journal     Hybrid Journal   (Followers: 3)
Barbaroi     Open Access  
Basic and Applied Social Psychology     Hybrid Journal   (Followers: 34)
Behavior Analysis in Practice     Full-text available via subscription   (Followers: 6)
Behavior Analysis: Research and Practice     Full-text available via subscription   (Followers: 2)
Behavior Analyst     Hybrid Journal   (Followers: 3)
Behavior Modification     Hybrid Journal   (Followers: 10)
Behavior Research Methods     Hybrid Journal   (Followers: 18)
Behavior Therapy     Hybrid Journal   (Followers: 45)
Behavioral Development Bulletin     Full-text available via subscription  
Behavioral Interventions     Hybrid Journal   (Followers: 8)
Behavioral Neuroscience     Full-text available via subscription   (Followers: 52)
Behavioral Sciences & the Law     Hybrid Journal   (Followers: 23)
Behavioral Sleep Medicine     Hybrid Journal   (Followers: 6)
Behaviour     Hybrid Journal   (Followers: 12)
Behaviour Research and Therapy     Hybrid Journal   (Followers: 17)
Behavioural and Cognitive Psychotherapy     Hybrid Journal   (Followers: 121)
Behavioural Processes     Hybrid Journal   (Followers: 7)
Biofeedback     Hybrid Journal   (Followers: 4)
BioPsychoSocial Medicine     Open Access   (Followers: 6)
BMC Psychology     Open Access   (Followers: 16)
Body, Movement and Dance in Psychotherapy: An International Journal for Theory, Research and Practice     Hybrid Journal   (Followers: 9)
Boletim Academia Paulista de Psicologia     Open Access  
Boletim de Psicologia     Open Access  
Brain Informatics     Open Access   (Followers: 1)
British Journal of Clinical Psychology     Full-text available via subscription   (Followers: 127)
British Journal of Developmental Psychology     Full-text available via subscription   (Followers: 36)
British Journal of Educational Psychology     Hybrid Journal   (Followers: 32)
British Journal of Health Psychology     Full-text available via subscription   (Followers: 42)
British Journal of Mathematical and Statistical Psychology     Full-text available via subscription   (Followers: 21)
British Journal of Psychology     Full-text available via subscription   (Followers: 58)
British Journal of Psychotherapy     Hybrid Journal   (Followers: 65)
British Journal of Social Psychology     Full-text available via subscription   (Followers: 33)
Burnout Research     Open Access   (Followers: 7)
Cadernos de psicanálise (Rio de Janeiro)     Open Access  
Cadernos de Psicologia Social do Trabalho     Open Access  
Canadian Art Therapy Association     Hybrid Journal  
Canadian Journal of Behavioural Science     Full-text available via subscription   (Followers: 5)
Canadian Journal of Experimental Psychology     Full-text available via subscription   (Followers: 12)
Canadian Psychology / Psychologie canadienne     Full-text available via subscription   (Followers: 11)
Case Studies in Sport and Exercise Psychology     Hybrid Journal  
Cendekia : Jurnal Kependidikan dan Kemasyarakatan     Open Access  
Child Development Perspectives     Hybrid Journal   (Followers: 27)
Child Development Research     Open Access   (Followers: 14)
Ciencia Cognitiva     Open Access   (Followers: 2)
Ciencia e Interculturalidad     Open Access  
Ciências & Cognição     Open Access  
Ciencias Psicológicas     Open Access  
Clínica y Salud     Open Access  
Clinical Medicine Insights : Psychiatry     Open Access   (Followers: 10)
Clinical Practice in Pediatric Psychology     Full-text available via subscription   (Followers: 10)
Clinical Psychological Science     Hybrid Journal   (Followers: 11)
Clinical Psychologist     Hybrid Journal   (Followers: 16)
Clinical Psychology & Psychotherapy     Hybrid Journal   (Followers: 67)
Clinical Psychology and Special Education     Open Access   (Followers: 1)
Clinical Psychology Review     Hybrid Journal   (Followers: 33)
Clinical Psychology: Science and Practice     Hybrid Journal   (Followers: 21)
Clinical Schizophrenia & Related Psychoses     Full-text available via subscription   (Followers: 8)
Coaching Psykologi - The Danish Journal of Coaching Psychology     Open Access   (Followers: 1)
Cogent Psychology     Open Access  
Cógito     Open Access  
Cognition & Emotion     Hybrid Journal   (Followers: 35)
Cognitive Behaviour Therapy     Hybrid Journal   (Followers: 14)
Cognitive Neuropsychology     Hybrid Journal   (Followers: 27)
Cognitive Psychology     Hybrid Journal   (Followers: 61)
Cognitive Research : Principles and Implications     Open Access  
Consciousness and Cognition     Hybrid Journal   (Followers: 26)
Construção Psicopedagógica     Open Access  
Consulting Psychology Journal : Practice and Research     Full-text available via subscription   (Followers: 3)
Contagion : Journal of Violence, Mimesis, and Culture     Full-text available via subscription   (Followers: 8)
Contemporary Educational Psychology     Hybrid Journal   (Followers: 22)
Contemporary School Psychology     Hybrid Journal   (Followers: 4)
Contextos Clínicos     Open Access  
Counseling Outcome Research and Evaluation     Hybrid Journal   (Followers: 10)
Counseling Psychologist     Hybrid Journal   (Followers: 14)
Counseling Psychology and Psychotherapy     Open Access   (Followers: 7)
Counselling and Psychotherapy Research : Linking research with practice     Hybrid Journal   (Followers: 21)
Counselling and Values     Hybrid Journal   (Followers: 2)
Counselling Psychology Quarterly     Hybrid Journal   (Followers: 10)
Couple and Family Psychoanalysis     Full-text available via subscription   (Followers: 1)
Couple and Family Psychology : Research and Practice     Full-text available via subscription   (Followers: 4)
Creativity Research Journal     Hybrid Journal   (Followers: 20)
Creativity. Theories - Research - Applications     Open Access   (Followers: 1)
Criminal Justice Ethics     Hybrid Journal   (Followers: 8)
Cuadernos de Neuropsicología     Open Access   (Followers: 1)
Cuadernos de Psicologia del Deporte     Open Access  
Cuadernos de Psicopedagogía     Open Access  
Cultural Diversity and Ethnic Minority Psychology     Full-text available via subscription   (Followers: 12)
Cultural-Historical Psychology     Open Access  
Culturas Psi     Open Access  
Culture and Brain     Hybrid Journal   (Followers: 4)
Current Addiction Reports     Hybrid Journal   (Followers: 10)
Current Behavioral Neuroscience Reports     Hybrid Journal   (Followers: 2)
Current Directions In Psychological Science     Hybrid Journal   (Followers: 48)
Current Opinion in Behavioral Sciences     Hybrid Journal   (Followers: 1)
Current Opinion in Psychology     Hybrid Journal   (Followers: 4)
Current Psychological Research     Hybrid Journal   (Followers: 14)
Current Psychology     Hybrid Journal   (Followers: 15)
Current psychology letters     Open Access   (Followers: 2)
Current Research in Psychology     Open Access   (Followers: 21)
Cyberpsychology, Behavior, and Social Networking     Hybrid Journal   (Followers: 14)
Decision     Full-text available via subscription   (Followers: 2)
Depression and Anxiety     Hybrid Journal   (Followers: 14)
Depression Research and Treatment     Open Access   (Followers: 13)
Developmental Cognitive Neuroscience     Open Access   (Followers: 16)
Developmental Neuropsychology     Hybrid Journal   (Followers: 15)
Developmental Psychobiology     Hybrid Journal   (Followers: 9)
Developmental Psychology     Full-text available via subscription   (Followers: 45)
Diagnostica     Hybrid Journal   (Followers: 2)
Dialectica     Hybrid Journal   (Followers: 1)
Discourse     Full-text available via subscription   (Followers: 9)
Diversitas: Perspectivas en Psicologia     Open Access  
Drama Therapy Review     Hybrid Journal   (Followers: 1)
Dreaming     Full-text available via subscription   (Followers: 11)
Drogues, santé et société     Full-text available via subscription  
Dynamics of Asymmetric Conflict: Pathways toward terrorism and genocide     Hybrid Journal   (Followers: 12)
Ecopsychology     Hybrid Journal   (Followers: 6)
ECOS - Estudos Contemporâneos da Subjetividade     Open Access  
Educational Psychology Review     Hybrid Journal   (Followers: 26)
Educational Psychology: An International Journal of Experimental Educational Psychology     Hybrid Journal   (Followers: 46)
Educazione sentimentale     Full-text available via subscription  
Electronic Journal of Research in Educational Psychology     Open Access   (Followers: 6)
Elpis - Czasopismo Teologiczne Katedry Teologii Prawosławnej Uniwersytetu w Białymstoku     Open Access  
Emotion     Full-text available via subscription   (Followers: 32)
Emotion Review     Hybrid Journal   (Followers: 17)
En-Claves del pensamiento     Open Access   (Followers: 1)
Enseñanza e Investigacion en Psicologia     Open Access  
Epiphany     Open Access   (Followers: 3)
Escritos de Psicología : Psychological Writings     Open Access   (Followers: 2)

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Journal Cover Current Behavioral Neuroscience Reports
  [2 followers]  Follow
   Hybrid Journal Hybrid journal (It can contain Open Access articles)
   ISSN (Online) 2196-2979
   Published by Springer-Verlag Homepage  [2345 journals]
  • Neural Correlates of Aggressive Behavior in Real Time: a Review of fMRI
           Studies of Laboratory Reactive Aggression
    • Authors: Jennifer R. Fanning; Sarah Keedy; Mitchell E. Berman; Royce Lee; Emil F. Coccaro
      Abstract: Purpose of review: Aggressive behavior has adaptive value in many natural environments; however, it places substantial burden and costs on human society. For this reason, there has long been interest in understanding the neurobiological basis of aggression. This interest, and the flourishing of neuroimaging research in general, has spurred the development of a large and growing scientific literature on the topic. As a result, a neural circuit model of aggressive behavior has emerged that implicates interconnected brain regions that are involved in emotional reactivity, emotion regulation, and cognitive control. Recent findings: Recently, behavioral paradigms that simulate provocative interactions have been adapted to neuroimaging protocols, providing an opportunity to directly probe the involvement of neural circuits in an aggressive interaction. Here we review neuroimaging studies of simulated aggressive interactions in research volunteers. We focus on studies that use a well-validated laboratory paradigm for reactive physical aggression and examine the neural correlates of provocation, retaliation, and evaluating punishment of an opponent. Summary: Overall, the studies reviewed support the involvement of neural circuits that support emotional reactivity, emotion regulation, and cognitive control in aggressive behavior. Based on a synthesis of this literature, future research directions are discussed.
      PubDate: 2017-05-20
      DOI: 10.1007/s40473-017-0115-8
  • Enduring Neural and Behavioral Effects of Early Life Adversity in Infancy:
           Consequences of Maternal Abuse and Neglect, Trauma and Fear
    • Authors: Julie Boulanger-Bertolus; Amanda M. White; Jacek Debiec
      Abstract: Purpose of Review Early life experiences have long-lasting influence on a child. For an infant, the quality of caregiving is one of the most critical factors supporting growth and development. Adverse social events in infancy have the potency to alter the child’s developmental trajectory and elevate the lifetime risk for a range of psychiatric disorders. Although clinical studies associate early childhood adversities with lifetime risk for mental disorders, the knowledge of underlying neural and molecular alterations leading to these disorders comes mostly from animal studies. In this article, we overview selected animal models of early life social adversity, including maternal abuse and neglect, and maternal trauma and fear. Recent Findings We first characterize the major behavioral and neural changes normally occurring in early life. We then present several animal models of maternally mediated early life adversity that contribute to reorient the developmental changes toward pathological outcomes. These models yielded to recently identified neurobiological mechanisms, including epigenetic alterations, through which these adversities lead to a lasting dysregulation of the stress response system, aberrant fear learning and memory, and increased anxiety or depression-like behaviors. Summary We conclude by emphasizing the unique role of the caregiver’s influences on the developing brain in infancy. Understanding of the infant’s mechanisms of vulnerability and resilience to maltreatment is essential for the advancement of novel therapeutic and preventive approaches.
      PubDate: 2017-05-19
      DOI: 10.1007/s40473-017-0112-y
  • Mistrustful and Misunderstood: a Review of Paranoid Personality Disorder
    • Authors: Royce J. Lee
      Abstract: Purpose of Review Paranoid personality disorder (PPD) has historically been neglected by science out of proportion to its prevalence or its association with negative clinical outcomes. This review provides an update on what is known about PPD regarding its prevalence, demographics, comorbidity, biological mechanism, risk factors, and relationship to psychotic disorders. Recent Findings PPD has long been the subject of a rich and prescient theoretical literature which has provided a surprisingly coherent account of the psychological mechanism of non-delusional paranoia. Available data indicate that PPD has a close relationship with childhood trauma and social stress. Descriptive data on a sample of 115 individuals with paranoid personality disorder is examined in comparison with a group of individuals with borderline personality disorder. The descriptive data largely confirm previously identified relationships between paranoid personality disorder and childhood trauma, violence, and race. We identify important similarities to and differences from borderline personality disorder. Summary PPD continues to be an important construct in the clinic and the laboratory. Available data lead to a reconsideration of the disorder as more closely related to trauma than to schizophrenia.
      PubDate: 2017-05-18
      DOI: 10.1007/s40473-017-0116-7
  • Caregiver-Child Relationships in Early Childhood: Interventions to Promote
           Well-Being and Reduce Risk for Psychopathology
    • Authors: M.M. Julian; J.M. Lawler; K.L. Rosenblum
      Abstract: Purpose of Review Early caregiver-child relationships are foundational to early development and central to efforts to promote well-being and prevent psychopathology. We discuss the role of caregiver-child relationships in early development and risk for psychopathology, and psychotherapeutic interventions targeting early caregiver-child relationships. Recent Findings Early risk for psychopathology is conferred through the dynamic interaction of biological and environmental factors, with sensitive caregiving playing a critical role. Recent research suggests that quality of caregiving moderates the effect of a child’s genetic risk for psychopathology. The protective role of sensitive caregiving is especially vital in the context of stress and trauma. Caregiver-child psychotherapeutic interventions are effective in increasing the rates of secure attachment and sensitive caregiving, and reducing early psychopathology. Emerging evidence suggests some interventions may be associated with changes to parents’ neural circuitry that underlies sensitive caregiving. Summary Relationship-based psychotherapeutic interventions are promising in the promotion of well-being and prevention of psychopathology in at-risk families.
      PubDate: 2017-05-10
      DOI: 10.1007/s40473-017-0110-0
  • What Can Transcranial Alternating Current Stimulation Tell Us About Brain
    • Authors: Christoph S. Herrmann; Daniel Strüber
      Abstract: Purpose of the Review Transcranial alternating current stimulation (tACS) allows to interfere with oscillatory brain activity. Here, we provide an overview of novel approaches for removing the tACS artefact to elucidate the mechanisms responsible for on-line tACS effects. Furthermore, we review recent findings on tACS after-effects and clinical applications. Recent Findings tACS-induced entrainment of alpha oscillations was demonstrated in on-line electroencephalography (EEG) and magnetoencephalography (MEG) recordings. On-line effects have also been revealed by innovative tACS protocols utilizing amplitude modulation, cross-frequency coupling, non-sinusoidal waveforms, and non-electrical physiological measures. tACS after-effects on alpha power exceeding 1-h duration have been reported, and a behavioral relevance of these physiological changes was shown for the first time. Summary Our understanding of tACS on-line effects greatly benefited from new artefact removal approaches. After-effects of varying duration have been consistently reported but the underlying mechanism is still unclear. tACS as a neurotherapeutic is only emerging, but first evidence for successful tACS interventions in neuropsychiatric and neurological disorders is encouraging.
      PubDate: 2017-05-09
      DOI: 10.1007/s40473-017-0114-9
  • Attention Processes Underlying Risk and Resilience in Behaviorally
           Inhibited Children
    • Authors: Heather A. Henderson; McLennon J.G. Wilson
      Abstract: Purpose of Review We briefly review the literature on behavioral inhibition (BI) in childhood and its associated social and emotional outcomes. We review the interplay of automatic and controlled attention processes in BI children and outline the relations between childhood BI and two components of effortful control (EC): response inhibition and attention switching. Recent Findings Contemporary research in cognitive and behavioral neuroscience indicates that components of EC differentially impact developmental risk for BI children. Response inhibition may inflate the risk of anxiety issues by promoting the inefficient deployment of attentional resources in social contexts, while attention shifting may serve as a protective factor by supporting dynamic social information processing. Summary The attentional processes subsumed under EC have diverse implications for the developmental trajectory of BI. Further research is necessary to identify the exact mechanisms by which the components of EC affect the manifestation of BI across development, and how this knowledge can guide early intervention efforts.
      PubDate: 2017-05-05
      DOI: 10.1007/s40473-017-0111-z
  • Multi-level Analysis of the Functioning of the Neurobiological Threat
           System in Adolescents: Implications for Suicide and Nonsuicidal
    • Authors: Melinda Westlund Schreiner; Kathryn R. Cullen; Bonnie Klimes-Dougan
      Abstract: Purpose of Review Advancement in knowledge of the neurobiological underpinnings of suicide and nonsuicidal self-injury (NSSI) will require multi-level approaches to understand the typical and atypical developmental processes in systems that are relevant to these aberrant behaviors. Here we focus on the threat system as a prototype, with the goal of integrating research investigating both the central and peripheral arms of this system, as well as the interplay between the brain and the body, during adolescence. Recent Findings An examination of research on the central and peripheral measures of the threat system in typically and atypically developing populations illustrates how the integration of multiple levels of analysis can be optimal in the comprehensive assessment of a system’s functioning. Further, this examination of the literature to date highlights important considerations for future work incorporating populations that engage in self-harm. Summary Future adolescent research investigating the neurobiology implicated in suicide and NSSI would benefit from the application of multiple units of analysis that is embedded in a developmental psychopathology perspective.
      PubDate: 2017-05-04
      DOI: 10.1007/s40473-017-0117-6
  • Prosocial Behavior and Depression: a Case for Developmental Gender
    • Authors: Gabriela Alarcón; Erika E. Forbes
      Abstract: Purpose of Review Prosocial behavior and depression are related constructs that both increase during adolescence and display gender-specific effects. The current review surveys literature examining the association between depressive symptoms and prosociality, measured with behavioral economic paradigms, across development and proposes a theoretical model explaining a mechanism through which adolescent girls have higher risk for depression than boys. Recent Findings Relative to healthy controls, prosocial behavior is reduced in adults with major depressive disorder (MDD) but may be increased in adolescents with MDD. The relationship between non-clinical levels of depressive symptoms and prosocial behavior remains to be studied experimentally; however, self-reported prosocial behavior is negatively associated with depressive symptoms in non-clinical adolescents, which may suggest a shift in the relation of prosocial behavior and depressive symptoms across the non-clinical (i.e., negative) to clinical range (i.e., positive). Summary The effect of gender on these developmental and clinical status shifts has not been studied but could have important implications for understanding the emergence of higher rates of depression in girls than boys during adolescence. We propose that girls are at heightened risk for depression due to higher social-evaluative concern and other-oriented prosocial motivation that emphasize the needs of others over the self, leading to more altruistic prosocial behavior (despite personal cost) and a higher burden that enables depressive symptoms.
      PubDate: 2017-05-02
      DOI: 10.1007/s40473-017-0113-x
  • Using New Approaches in Neurobiology to Rethink Stress-Induced Amnesia
    • Authors: Jelena Radulovic
      Abstract: Purpose of Review Psychological stress can impact memory systems in several different ways. In individuals with healthy defense and coping systems, stress results in the formation of negatively valenced memories whose ability to induce emotional and somatic distress subsides with time. Vulnerable individuals, however, go on to develop stress-related disorders such as post-traumatic stress disorder (PTSD) and suffer from significant memory abnormalities. Whether expressed as intrusive trauma memories, partial amnesia, or dissociative amnesia, such abnormalities are thought to be the core source of patients’ symptoms, which are often debilitating and implicate an entire socio-cognitive-affective spectrum. Recent Findings With this in mind, and focusing on stress-responsive hippocampal microcircuits, this article highlights recent advances in the neurobiology of memory that allow us to (1) isolate and visualize memory circuits, (2) change their activity using genetic tools and state-dependent manipulations, and (3) directly examine their impact on socio-affective circuits and global network connectivity. By integrating these approaches, we are now in a position to address important questions that have troubled psychiatry for a long time—questions such as are traumatic memories special, and why are stress effects on memory diverse. Summary Furthering our fundamental understanding of memory in the framework of adaptive and maladaptive stress responses has the potential to boost the development of new treatments that can benefit patients suffering from psychological trauma.
      PubDate: 2017-02-21
      DOI: 10.1007/s40473-017-0109-6
  • The Psychosocial Aspects of the Gilles de la Tourette Syndrome: Empirical
           Evidence from the Literature
    • Authors: Mary May Robertson; Valsamma Eapen
      Abstract: Objective A literature review suggests that Gilles de la Tourette syndrome (GTS) is common but under-diagnosed and under-reported, and the consequences and impact are not fully understood. This review is focussed on the adverse psychosocial consequences experienced by many GTS patients which, in turn, cause significant distress and disadvantage to both the patients and their families. Method A review of the literature was conducted using Pubmed and Medline under the headings Tourette, psychosocial, stigma, stress and suicide, and also, cross-references were made from relevant sources based on the authors’ experience in the field. Results Many of the difficulties of GTS are experienced within the individual (the “inner sensations”), but some are due to the loud vocal tics as well as socially stigmatising nature of some of the motor tics (e.g. spitting) and the “possibly offensive” copropraxia. In other instances, this may be linked to the co-morbidity (e.g. ADHD, OCD) and co-existing psychopathology (e.g. depression, conduct disorder) that occur in up to 90% of people with GTS. More quantitative research into the psychosocial aspects and sequelae of having GTS are suggested. Conclusions Apart from managing and treating the individual with GTS in a comprehensive way, the education of the general public, teachers, doctors and employers is of vital importance to improve the psychosocial aspects of the person with GTS.
      PubDate: 2017-02-09
      DOI: 10.1007/s40473-017-0107-8
  • Network-Guided Transcranial Magnetic Stimulation for Depression
    • Authors: Marc J. Dubin; Conor Liston; Michael A. Avissar; Irena Ilieva; Faith M. Gunning
      Abstract: Purpose of Review First, we will identify candidate predictive biomarkers of antidepressant response of TMS based on the neuroimaging literature. Next, we will review the effects of TMS on networks involved in depression. Finally, we will discuss ways in which our current understanding of network engagement by TMS may be used to optimize its antidepressant effect. Recent Findings The past few years has seen significant interest in the antidepressant mechanisms of TMS. Studies using functional neuroimaging and neurochemical imaging have demonstrated engagement of networks known to be important in depression. Current evidence supports a model whereby TMS normalizes network function gradually over the course of several treatments. This may, in turn, mediate its antidepressant effect. Summary One strategy to optimize the antidepressant effect of TMS is to more precisely target networks relevant in depression. We propose methods to achieve this using functional and neurochemical imaging.
      PubDate: 2017-02-07
      DOI: 10.1007/s40473-017-0108-7
  • Computational Psychiatry in Borderline Personality Disorder
    • Authors: Sarah K Fineberg; Dylan S Stahl; Philip R Corlett
      Abstract: Purpose of Review We review the literature on the use and potential use of computational psychiatry methods in borderline personality disorder. Recent Findings Computational approaches have been used in psychiatry to increase our understanding of the molecular, circuit, and behavioral basis of mental illness. This is of particular interest in BPD, where the collection of ecologically valid data, especially in interpersonal settings, is becoming more common and more often subject to quantification. Methods that test learning and memory in social contexts, collect data from real-world settings, and relate behavior to molecular and circuit networks are yielding data of particular interest. Summary Research in BPD should focus on collaborative efforts to design and interpret experiments with direct relevance to core BPD symptoms and potential for translation to the clinic.
      PubDate: 2017-02-04
      DOI: 10.1007/s40473-017-0104-y
  • Monoamine Oxidase A in Antisocial Personality Disorder and Borderline
           Personality Disorder
    • Authors: Nathan J. Kolla; Sarah A. Vinette
      Abstract: Purpose of Review Variation in the monoamine oxidase A (MAO-A) gene and MAO-A enzyme levels have been linked to antisocial behavior and aggression in clinical and non-clinical populations. Here, we provide an overview of the genetic, epigenetic, and neuroimaging research that has examined MAO-A structure and function in antisocial personality disorder (ASPD) and borderline personality disorder (BPD). Recent Findings The low-activity MAO-A variable nucleotide tandem repeat genetic polymorphism has shown a robust association with large samples of violent and seriously violent offenders, many of whom had ASPD. A recent positron emission tomography (PET) study of ASPD similarly revealed low MAO-A density in brain regions thought to contribute to the psychopathology of the condition. By contrast, PET has also demonstrated that brain MAO-A levels are increased in BPD and that they relate to symptoms of low mood and suicidality. Summary Candidate gene studies have produced the most compelling evidence connecting MAO-A genetic variants to both ASPD and BPD. Still, conflicting results abound in the literature, making it highly unlikely that ASPD or BPD is related to a specific MAO-A genetic variant. Future research should strive to examine how MAO-A genotypes interact with broad-spectrum environmental influences to produce brain endophenotypes that may ultimately become tractable targets for novel treatment strategies.
      PubDate: 2017-02-03
      DOI: 10.1007/s40473-017-0102-0
  • What Works in the Treatment of Borderline Personality Disorder
    • Authors: Lois W. Choi-Kain; Ellen F. Finch; Sara R. Masland; James A. Jenkins; Brandon T. Unruh
      Abstract: Purpose of the Review This review summarizes advances in treatments for adults with borderline personality disorder (BPD) in the last 5 years. Recent Findings Evidence-based advances in the treatment of BPD include a delineation of generalist models of care in contrast to specialist treatments, identification of essential effective elements of dialectical behavioral therapy (DBT), and the adaptation of DBT treatment to manage PTSD and BPD. Studies on pharmacological interventions remain limited and have not provided evidence that any specific medications can provide stand-alone treatment. Summary The research on treatment in BPD is leading to a distillation of intensive packages of treatment to be more broadly and practically implemented in most treatment environments through generalist care models and pared down forms of intensive treatments (e.g., informed case management plus DBT skills training groups). Evidence-based integrations of DBT and exposure therapy for PTSD provide support for changing practices to simultaneously treat PTSD and BPD.
      PubDate: 2017-02-03
      DOI: 10.1007/s40473-017-0103-z
  • Using Genetics to Improve Addiction Treatment Outcomes
    • Authors: Cheyenne Allenby; Mary Falcone
      Abstract: Purpose of Review This review will discuss recent studies that have employed pharmacogenetic findings to advance development of therapeutics and improve treatment outcomes for substance use disorder. Recent Findings Pharmacogenetic studies have inspired new treatment targets for smoking cessation, with mixed results. Promising initial evidence that mu-opioid receptor genotype (OPRM1 A118G) was associated with response to naltrexone treatment for alcohol dependence has not been supported in prospective trials. The nicotine metabolite ratio (NMR) may be useful for predicting response to smoking cessation treatment. Candidate gene studies suggest several genes that may identify responders for cocaine or opiate pharmacotherapy, but these studies require replication. Summary Significant progress has been made in pharmacogenetics studies of addiction treatment; however, efforts must be made to bridge the translational gap. Robust prospective studies are needed in order to gather sufficient information on the clinical utility of pharmacogenetic testing prior to implementation in a clinical setting.
      PubDate: 2017-01-30
      DOI: 10.1007/s40473-017-0106-9
  • Neurocognitive Function as a Treatment Target for Tobacco Use Disorder
    • Authors: Cendrine D. Robinson; Andrew J. Waters; Nicole Kang; Mehmet Sofuoglu
      Abstract: Purpose of Review Novel approaches are needed to improve the treatment of tobacco use disorder (TUD). Two distinct literatures have examined the impact of cognitive function in the maintenance of TUD. One approach has focused on automatic cognitive processes, and the second approach has addressed the role of executive cognitive processes. This review focuses on interventions that target automatic and cognitive processes for TUD. Recent Findings There appears to be evidence that attention re-training (AR) reduces automatic cognitions, but the effect on smoking requires further research. Several medications including varenicline, bupropion, and galantamine can improve executive processes and potentially reduce craving and smoking. However, whether the beneficial effects of these medications are mediated by cognitive improvement remains to be determined. Other strategies including the approach-avoidance task, transcranial direct current stimulation, and exercise require further study. Summary Most research focuses on targeting automatic and controlled cognitive processes, separately in relatively small samples. Future research should consider targeting both processes simultaneously.
      PubDate: 2017-01-30
      DOI: 10.1007/s40473-017-0105-x
  • Modeling Brain Development Using Human Cells for the Study and Treatment
           of Zika Virus Infections
    • Abstract: Purpose of Review Cellular reprogramming now permits the generation of a renewable source of disease-relevant human cells for modeling biological systems and for high-throughput drug screening. Advances in modeling human brain development to study Zika infections and its association with microcephaly are discussed in this commentary. Recent Findings Human-induced pluripotent stem cells can be differentiated to cell types similar to those in the developing brain using both 2D and 3D cell culture systems. Zika virus targets proliferating neural progenitor cells in these systems and the resultant cell death provides evidence that Zika virus infections are causal for microcephaly. Drug repurposing screens using human cells vulnerable to infection has led to the identification of antiviral and neuroprotective therapeutic candidates. Summary Together with in vivo animal models, new stem cell-based technologies to model features of the developing and mature nervous system provide a platform for accelerated drug development to combat infectious diseases with neurological consequences.
      PubDate: 2016-11-03
      DOI: 10.1007/s40473-016-0101-6
  • Using Placebo Response to Pain as a Predictor of Placebo Response in Mood
    • Authors: Sara Costi; Katherine Collins; Michael Davidson; Dan V. Iosifescu
      Abstract: Recent Findings Major depressive disorder (MDD) is the leading cause of disability worldwide and available pharmacological treatments are only partially effective. The development of new drugs is hindered by the high proportion of MDD patients who respond to placebo. Data from neuroimaging studies suggests convergence in the activation of brain circuits during placebo response to analgesia and placebo response in depression. Purpose of Review In the current work, we reviewed the published literature about placebo response in depression and in pain, focusing on the similarities within the neurobiological pathways that could facilitate identification of predictors of antidepressant placebo response. Summary Data suggests that placebo response in both pain and depression are mediated by reward neurocircuitry. The neuro-functional overlap between these networks suggests a novel strategy to prospectively identify placebo responders in MDD.
      PubDate: 2016-10-24
      DOI: 10.1007/s40473-016-0092-3
  • Mindfulness Training for Emotional and Cognitive Health in Late Life
    • Authors: Moria J. Smoski; Andrew McClintock; Lori Keeling
      Abstract: Purpose of Review There is a growing interest in psychosocial interventions that can enhance emotional and cognitive health in older adults, both to treat psychopathology and/or cognitive decline and to prolong optimum functioning in healthy individuals. Mindfulness-based interventions (MBIs) have been proposed as an accessible and effective means of promoting emotional and cognitive health. This article reviews recent clinical trials of MBIs in older adults. Recent Findings There is growing support for MBIs as a means to address mild to moderate clinical concerns, including depression, anxiety, sleep, and subjective memory or other cognitive complains but little evidence that MBIs improve functioning in already healthy individuals. Summary MBIs may be effective for older adults with mild to moderate emotional and cognitive dysfunction. Future longitudinal work is needed to test if MBIs are an effective means of prevention of emotional or cognitive decline.
      PubDate: 2016-10-14
      DOI: 10.1007/s40473-016-0097-y
  • Magnetic Seizure Therapy: an Evolution of Convulsive Therapy
    • Authors: Katalin Martits-Chalangari; Alexis Milton; Mustafa M. Husain
      Abstract: Purpose of Review Treatment-resistant depression (TRD) affects a significant subset of depressed patients. It is estimated that about 30 % of patients with major depressive disorder do not respond to standard treatments. For these patients, electroconvulsive therapy (ECT) remains the most effective treatment despite being limited by its side effects. Modifications to ECT parameters have suggested that it may be possible to separate the therapeutic effects of convulsive therapy from the production of side effects. Recent Findings Magnetic seizure therapy (MST), which uses electromagnetic induction to induce a seizure, is an alternative, experimental convulsive treatment for major depression. Seizures induced by MST are more focal than those produced by ECT, thereby offering greater control over the induced electric field. Most importantly, it offers the potential to provide antidepressant effect without cognitive side effects. Recent findings have further shown the effectiveness of MST and compared cognitive and metabolic side effects to ECT. Summary This article reviews the current literature for clinical studies on MST. While initial results are promising, future work is needed to compare MST efficacy with other antidepressant treatments.
      PubDate: 2016-10-06
      DOI: 10.1007/s40473-016-0094-1
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