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  Subjects -> PSYCHOLOGY (Total: 918 journals)
Showing 1 - 174 of 174 Journals sorted alphabetically
Acción Psicológica     Open Access   (Followers: 3)
Acta Colombiana de Psicología     Open Access   (Followers: 5)
Acta Comportamentalia     Open Access   (Followers: 3)
Acta de Investigación Psicológica     Open Access   (Followers: 3)
Acta Psychologica     Hybrid Journal   (Followers: 25)
Activités     Open Access   (Followers: 1)
Actualidades en Psicologia     Open Access   (Followers: 2)
Ad verba Liberorum : Journal of Linguistics & Pedagogy & Psychology     Open Access   (Followers: 9)
Addictive Behaviors Reports     Open Access   (Followers: 7)
ADHD Attention Deficit and Hyperactivity Disorders     Hybrid Journal   (Followers: 23)
ADHD Report The     Full-text available via subscription   (Followers: 9)
Advances in Experimental Social Psychology     Full-text available via subscription   (Followers: 46)
Advances in Mental Health     Hybrid Journal   (Followers: 77)
Advances in Methods and Practices in Psychological Science     Full-text available via subscription   (Followers: 3)
Advances in Physiotherapy     Hybrid Journal   (Followers: 60)
Advances in Psychology     Full-text available via subscription   (Followers: 64)
Advances in the Study of Behavior     Full-text available via subscription   (Followers: 31)
African Journal of Cross-Cultural Psychology and Sport Facilitation     Full-text available via subscription   (Followers: 5)
Aggression and Violent Behavior     Hybrid Journal   (Followers: 443)
Aggressive Behavior     Hybrid Journal   (Followers: 17)
Aging, Neuropsychology, and Cognition     Hybrid Journal   (Followers: 40)
Ágora - studies in psychoanalytic theory     Open Access   (Followers: 3)
Aletheia     Open Access   (Followers: 1)
American Behavioral Scientist     Hybrid Journal   (Followers: 18)
American Imago     Full-text available via subscription   (Followers: 3)
American Journal of Applied Psychology     Open Access   (Followers: 42)
American Journal of Community Psychology     Hybrid Journal   (Followers: 26)
American Journal of Health Behavior     Full-text available via subscription   (Followers: 24)
American Journal of Orthopsychiatry     Hybrid Journal   (Followers: 5)
American Journal of Psychoanalysis     Hybrid Journal   (Followers: 22)
American Psychologist     Full-text available via subscription   (Followers: 204)
Anales de Psicología     Open Access   (Followers: 2)
Análise Psicológica     Open Access   (Followers: 1)
Análisis y Modificación de Conducta     Open Access   (Followers: 2)
Analitika : Jurnal Magister Psikologi Uma     Open Access  
Analysis     Full-text available via subscription   (Followers: 4)
Annual Review of Clinical Psychology     Full-text available via subscription   (Followers: 72)
Annual Review of Organizational Psychology and Organizational Behavior     Full-text available via subscription   (Followers: 33)
Annual Review of Psychology     Full-text available via subscription   (Followers: 249)
Anuario de Psicología / The UB Journal of Psychology     Open Access   (Followers: 1)
Anuario de Psicología Jurídica     Open Access   (Followers: 1)
Anxiety, Stress & Coping: An International Journal     Hybrid Journal   (Followers: 25)
Applied and Preventive Psychology     Hybrid Journal   (Followers: 16)
Applied Cognitive Psychology     Hybrid Journal   (Followers: 74)
Applied Neuropsychology : Adult     Hybrid Journal   (Followers: 40)
Applied Neuropsychology : Child     Hybrid Journal   (Followers: 22)
Applied Psycholinguistics     Hybrid Journal   (Followers: 19)
Applied Psychological Measurement     Hybrid Journal   (Followers: 20)
Applied Psychology     Hybrid Journal   (Followers: 166)
Applied Psychology: Health and Well-Being     Hybrid Journal   (Followers: 53)
Applied Psychophysiology and Biofeedback     Hybrid Journal   (Followers: 8)
Archive for the Psychology of Religion / Archiv für Religionspychologie     Hybrid Journal   (Followers: 23)
Archives of Clinical Neuropsychology     Hybrid Journal   (Followers: 32)
Archives of Scientific Psychology     Open Access   (Followers: 4)
Arquivos Brasileiros de Psicologia     Open Access   (Followers: 1)
Asia Pacific Journal of Counselling and Psychotherapy     Hybrid Journal   (Followers: 8)
Asia-Pacific Psychiatry     Hybrid Journal   (Followers: 4)
Asian American Journal of Psychology     Full-text available via subscription   (Followers: 5)
Asian Journal of Behavioural Studies     Open Access  
Asian Journal of Business Ethics     Hybrid Journal   (Followers: 9)
Assessment     Hybrid Journal   (Followers: 12)
Attachment: New Directions in Psychotherapy and Relational Psychoanalysis     Full-text available via subscription   (Followers: 16)
Attention, Perception & Psychophysics     Full-text available via subscription   (Followers: 13)
Australasian Journal of Organisational Psychology     Hybrid Journal   (Followers: 8)
Australian and Aotearoa New Zealand Psychodrama Association Journal     Full-text available via subscription  
Australian Educational and Developmental Psychologist, The     Full-text available via subscription   (Followers: 8)
Australian Journal of Psychology     Hybrid Journal   (Followers: 18)
Australian Journal of Rehabilitation Counseling     Full-text available via subscription   (Followers: 4)
Australian Psychologist     Hybrid Journal   (Followers: 11)
Autism Research     Hybrid Journal   (Followers: 38)
Autism Research and Treatment     Open Access   (Followers: 29)
Autism's Own     Open Access   (Followers: 2)
Autism-Open Access     Open Access   (Followers: 6)
Avaliação Psicológica     Open Access  
Avances en Psicologia Latinoamericana     Open Access   (Followers: 1)
Aviation Psychology and Applied Human Factors     Hybrid Journal   (Followers: 19)
Balint Journal     Hybrid Journal   (Followers: 3)
Barbaroi     Open Access  
Basic and Applied Social Psychology     Hybrid Journal   (Followers: 37)
Behavior Analysis in Practice     Full-text available via subscription   (Followers: 8)
Behavior Analysis: Research and Practice     Full-text available via subscription   (Followers: 2)
Behavior Analyst     Hybrid Journal   (Followers: 4)
Behavior Modification     Hybrid Journal   (Followers: 10)
Behavior Research Methods     Hybrid Journal   (Followers: 21)
Behavior Therapy     Hybrid Journal   (Followers: 50)
Behavioral Development Bulletin     Full-text available via subscription  
Behavioral Interventions     Hybrid Journal   (Followers: 10)
Behavioral Neuroscience     Full-text available via subscription   (Followers: 54)
Behavioral Sciences & the Law     Hybrid Journal   (Followers: 23)
Behavioral Sleep Medicine     Hybrid Journal   (Followers: 7)
Behaviormetrika     Hybrid Journal  
Behaviour     Hybrid Journal   (Followers: 12)
Behaviour Change     Full-text available via subscription   (Followers: 12)
Behaviour Research and Therapy     Hybrid Journal   (Followers: 18)
Behavioural and Cognitive Psychotherapy     Hybrid Journal   (Followers: 138)
Behavioural Processes     Hybrid Journal   (Followers: 8)
Biofeedback     Hybrid Journal   (Followers: 4)
BioPsychoSocial Medicine     Open Access   (Followers: 7)
BMC Psychology     Open Access   (Followers: 17)
Body, Movement and Dance in Psychotherapy: An International Journal for Theory, Research and Practice     Hybrid Journal   (Followers: 10)
Boletim Academia Paulista de Psicologia     Open Access  
Boletim de Psicologia     Open Access  
Brain Informatics     Open Access  
British Journal of Clinical Psychology     Full-text available via subscription   (Followers: 151)
British Journal of Developmental Psychology     Full-text available via subscription   (Followers: 37)
British Journal of Educational Psychology     Hybrid Journal   (Followers: 35)
British Journal of Health Psychology     Full-text available via subscription   (Followers: 46)
British Journal of Mathematical and Statistical Psychology     Full-text available via subscription   (Followers: 21)
British Journal of Psychology     Full-text available via subscription   (Followers: 60)
British Journal of Psychotherapy     Hybrid Journal   (Followers: 68)
British Journal of Social Psychology     Full-text available via subscription   (Followers: 33)
Burnout Research     Open Access   (Followers: 8)
Cadernos de psicanálise (Rio de Janeiro)     Open Access  
Cadernos de Psicologia Social do Trabalho     Open Access  
Canadian Art Therapy Association     Hybrid Journal  
Canadian Journal of Behavioural Science     Full-text available via subscription   (Followers: 5)
Canadian Journal of Experimental Psychology     Full-text available via subscription   (Followers: 15)
Canadian Psychology / Psychologie canadienne     Full-text available via subscription   (Followers: 14)
Case Studies in Sport and Exercise Psychology     Hybrid Journal   (Followers: 1)
Cendekia : Jurnal Kependidikan dan Kemasyarakatan     Open Access  
Child Development Perspectives     Hybrid Journal   (Followers: 29)
Child Development Research     Open Access   (Followers: 17)
Ciencia Cognitiva     Open Access   (Followers: 2)
Ciencia e Interculturalidad     Open Access   (Followers: 1)
Ciências & Cognição     Open Access  
Ciencias Psicológicas     Open Access  
Clínica y Salud     Open Access  
Clinical Medicine Insights : Psychiatry     Open Access   (Followers: 10)
Clinical Practice in Pediatric Psychology     Full-text available via subscription   (Followers: 11)
Clinical Psychological Science     Hybrid Journal   (Followers: 13)
Clinical Psychologist     Hybrid Journal   (Followers: 18)
Clinical Psychology & Psychotherapy     Hybrid Journal   (Followers: 72)
Clinical Psychology and Special Education     Open Access   (Followers: 3)
Clinical Psychology Review     Hybrid Journal   (Followers: 41)
Clinical Psychology: Science and Practice     Hybrid Journal   (Followers: 22)
Clinical Schizophrenia & Related Psychoses     Full-text available via subscription   (Followers: 9)
Coaching : Theorie & Praxis     Open Access  
Coaching Psykologi - The Danish Journal of Coaching Psychology     Open Access   (Followers: 1)
Cogent Psychology     Open Access  
Cógito     Open Access  
Cognition & Emotion     Hybrid Journal   (Followers: 43)
Cognitive Behaviour Therapist     Hybrid Journal   (Followers: 13)
Cognitive Behaviour Therapy     Hybrid Journal   (Followers: 17)
Cognitive Neuropsychology     Hybrid Journal   (Followers: 35)
Cognitive Psychology     Hybrid Journal   (Followers: 71)
Cognitive Research : Principles and Implications     Open Access   (Followers: 3)
Consciousness and Cognition     Hybrid Journal   (Followers: 32)
Construção Psicopedagógica     Open Access  
Consulting Psychology Journal : Practice and Research     Full-text available via subscription   (Followers: 4)
Contagion : Journal of Violence, Mimesis, and Culture     Full-text available via subscription   (Followers: 7)
Contemporary Educational Psychology     Hybrid Journal   (Followers: 26)
Contemporary School Psychology     Hybrid Journal   (Followers: 4)
Contextos Clínicos     Open Access  
Counseling Outcome Research and Evaluation     Hybrid Journal   (Followers: 12)
Counseling Psychologist     Hybrid Journal   (Followers: 16)
Counseling Psychology and Psychotherapy     Open Access   (Followers: 11)
Counselling and Psychotherapy Research : Linking research with practice     Hybrid Journal   (Followers: 26)
Counselling and Values     Hybrid Journal   (Followers: 3)
Counselling Psychology Quarterly     Hybrid Journal   (Followers: 11)
Couple and Family Psychoanalysis     Full-text available via subscription   (Followers: 1)
Couple and Family Psychology : Research and Practice     Full-text available via subscription   (Followers: 7)
Creativity Research Journal     Hybrid Journal   (Followers: 24)
Creativity. Theories - Research - Applications     Open Access   (Followers: 5)
Criminal Justice Ethics     Hybrid Journal   (Followers: 8)
Cuadernos de Neuropsicología     Open Access   (Followers: 1)
Cuadernos de Psicologia del Deporte     Open Access  
Cuadernos de Psicopedagogía     Open Access  
Cultural Diversity and Ethnic Minority Psychology     Full-text available via subscription   (Followers: 15)
Cultural-Historical Psychology     Open Access   (Followers: 2)
Culturas Psi     Open Access  
Culture and Brain     Hybrid Journal   (Followers: 4)
Current Addiction Reports     Hybrid Journal   (Followers: 12)
Current Behavioral Neuroscience Reports     Hybrid Journal   (Followers: 2)
Current Directions In Psychological Science     Hybrid Journal   (Followers: 56)
Current Opinion in Behavioral Sciences     Hybrid Journal   (Followers: 3)
Current Opinion in Psychology     Hybrid Journal   (Followers: 6)
Current Psychological Research     Hybrid Journal   (Followers: 14)
Current Psychology     Hybrid Journal   (Followers: 17)
Current psychology letters     Open Access   (Followers: 2)
Current Research in Psychology     Open Access   (Followers: 20)
Cyberpsychology, Behavior, and Social Networking     Hybrid Journal   (Followers: 16)
Decision     Full-text available via subscription   (Followers: 4)
Depression and Anxiety     Hybrid Journal   (Followers: 22)
Depression Research and Treatment     Open Access   (Followers: 15)
Development and Psychopathology     Hybrid Journal   (Followers: 8)
Developmental Cognitive Neuroscience     Open Access   (Followers: 18)
Developmental Neuropsychology     Hybrid Journal   (Followers: 20)
Developmental Psychobiology     Hybrid Journal   (Followers: 9)
Developmental Psychology     Full-text available via subscription   (Followers: 47)
Diagnostica     Hybrid Journal   (Followers: 2)
Dialectica     Hybrid Journal   (Followers: 1)
Discourse     Full-text available via subscription   (Followers: 9)
Diversitas: Perspectivas en Psicologia     Open Access  
Drama Therapy Review     Hybrid Journal   (Followers: 2)
Dreaming     Full-text available via subscription   (Followers: 11)
Drogues, santé et société     Full-text available via subscription  
Dynamics of Asymmetric Conflict: Pathways toward terrorism and genocide     Hybrid Journal   (Followers: 15)
Eat, Sleep, Work     Open Access  
Ecopsychology     Hybrid Journal   (Followers: 8)
ECOS - Estudos Contemporâneos da Subjetividade     Open Access  

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Journal Cover Current Behavioral Neuroscience Reports
  [2 followers]  Follow
   Hybrid Journal Hybrid journal (It can contain Open Access articles)
   ISSN (Online) 2196-2979
   Published by Springer-Verlag Homepage  [2351 journals]
  • Correction to: Monoamine Oxidase a in Antisocial Personality Disorder and
           Borderline Personality Disorder
    • Authors: Nathan J. Kolla; Sarah A. Vinette
      Abstract: The article Monoamine Oxidase A in Antisocial Personality Disorder and Borderline Personality Disorder, written by Nathan J. Kolla and Sarah A. Vinette, was originally published Online First without open access.
      PubDate: 2018-03-01
      DOI: 10.1007/s40473-018-0148-7
  • Borderline Personality Disorder: Refinements in Phenotypic and Cognitive
    • Authors: Jacob W. Koudys; Tahira Gulamani; Anthony C. Ruocco
      Abstract: Purpose of Review Advancements in taxometric and dimensional approaches to personality psychopathology have pushed for refinements to the borderline personality disorder (BPD) phenotype, but proposed revisions to the diagnosis in major nosological systems hinge in part on evidence to support their validity. We review recent phenotypic and cognitive research on BPD and consider ways that changes to the phenotype may be validated using cognitive measures. Recent Findings Phenotypic research on BPD has identified core symptom dimensions underlying the DSM diagnosis, which also aggregate in families. While a unidimensional model of the disorder has been found in some studies, latent subgroups within the diagnosis have also been uncovered. Cognitive findings reveal deficits primarily in executive functions relevant to self-regulation but also in episodic memory and attentional abilities. Summary Cognitive functioning should be considered as a potential validator of proposed changes or refinements to the BPD phenotype, including categorical and dimensional conceptualizations.
      PubDate: 2018-03-01
      DOI: 10.1007/s40473-018-0145-x
  • The Cognitive Neuroscience of Psychological Treatment Action in Depression
           and Anxiety
    • Authors: Katherine S. Young; Michelle G. Craske
      Abstract: Purpose of Review Psychological treatments for anxiety and depression are not universally effective, with many individuals continuing to experience symptoms after treatment. A better understanding of how these treatments work has the potential to inform treatment development and optimization. Neuroimaging studies provide one level of analysis to investigate mechanisms of treatment action. Here, we review recent studies using this approach to assess mechanisms of psychological treatments. Recent Findings Cognitive behavioral therapy for anxiety and depression was associated with changes in activation of amygdala, ACC, and medial/inferior prefrontal cortices. Changes in connectivity between amygdala and prefrontal cortical regions were also demonstrated highlighting a role for altered functioning of neural circuitry implicated in emotion regulation. Summary Greater concordance between neuroscience and clinical researchers would allow more focused investigation of treatment-specific and treatment-general mechanisms. More standardization in study design would facilitate the ability to compare effects across studies.
      PubDate: 2018-02-22
      DOI: 10.1007/s40473-018-0137-x
  • Traumatic Stress Epigenetics
    • Authors: John R. Pfeiffer; Leon Mutesa; Monica Uddin
      Abstract: Purpose of Review Traumatic stress has profound impacts on many domains of life, yet the mechanisms that confer risk for or resilience to the development of traumatic stress-related psychopathologies are still very much under investigation. The current review highlights recent developments in the field of traumatic stress epigenetics in humans. Recent Findings Recent results reveal traumatic stress-related epigenetic dysregulation in neural, endocrine, and immune system genes and associated networks. Emerging work combining imaging with epigenetic measures holds promise for addressing the correspondence between peripheral and central effects of traumatic stress. A growing literature is also documenting the transgenerational effects of prenatal stress exposures in humans. Summary Moving forward, increasing focus on epigenetic marks of traumatic stress in CNS tissue will create a clearer picture of the relevance of peripheral measures; PTSD brain banks will help in this regard. Similarly, leveraging multigenerational birth cohort data will do much to clarify the extent of transgenerational epigenetic effects of traumatic stress. Greater efforts should be made towards developing prospective studies with longitudinal design.
      PubDate: 2018-02-13
      DOI: 10.1007/s40473-018-0143-z
  • Current Understanding of the Neural Mechanisms of Dissociation in
           Borderline Personality Disorder
    • Authors: Annegret Krause-Utz; Bernet Elzinga
      Abstract: Purpose of Review In this article, we aim to give an overview over recent neuroimaging research on dissociation in borderline personality disorder (BPD). Stress-related dissociation is highly prevalent in BPD, while so far only little is known about its neural underpinnings. Recent Findings Based on research in depersonalization and the dissociative subtype of posttraumatic stress disorder, it has been proposed that dissociation involves alterations in a cortico-limbic network. In BPD, neuroimaging research explicitly focusing on dissociation is still scarce. Summary Functional neuroimaging studies have provided preliminary evidence for an altered recruitment and interplay of fronto-limbic regions (amygdala, anterior cingulate, inferior frontal gyrus, medial and dorsolateral prefrontal cortices) and temporoparietal areas (superior temporal gyrus, inferior parietal lobule, fusiform gyrus), which may underlie disrupted affective-cognitive processing during dissociation in BPD. More neuroimaging research with larger samples, clinical control groups, and repeated measurements is needed to deepen the understanding of dissociation in BPD.
      PubDate: 2018-02-12
      DOI: 10.1007/s40473-018-0146-9
  • Developmental Aspects of Schizotypy and Suspiciousness: a Review
    • Authors: Keri K. Wong; Adrian Raine
      Abstract: Purpose of the Review This review identifies the early developmental processes that contribute to schizotypy and suspiciousness in adolescence and adulthood. It includes the most recent literature on these phenomena in childhood. Recent Findings The early developmental processes that affect schizotypy and paranoia in later life are complex. In contrast to existing studies of psychiatric patients and clinical/nonclinical adult populations, the study of schizotypy and suspiciousness in young children and adolescents is possible due to new child-appropriate dimensional assessments. New assessments and the advancement of technology (e.g., virtual reality in mental health) as well as statistical modeling (e.g., mediation and latent-class analyses) in large data have helped identified the developmental aspects (e.g., psychosocial, neurocognitive and brain factors, nutrition, and childhood correlates) that predict schizotypy and suspiciousness in later life. Summary Prospective longitudinal designs in community youths can enhance our understanding of the etiology of schizophrenia-spectrum disorders and, in the future, the development of preventive interventions by extending adult theories and interventions to younger populations.
      PubDate: 2018-02-09
      DOI: 10.1007/s40473-018-0144-y
  • Inter-relationship of the Intestinal Microbiome, Diet, and Mental Health
    • Authors: Nieves Pizarro; Rafael de la Torre
      Abstract: Purpose of the Review An unbalanced microbiota (dysbiosis) has been associated with or causative for a large array of human pathologies, including cognitive/emotional-related disorders. This review focuses on recent findings that address the restoration of a dysbiotic microbiota by dietary interventions with the main purpose of influencing brain function. Recent Findings Recent research strongly suggests a critical connection between dietary habits, cognitive performance, and microbiota, but a thorough study of this inter-relationship presents a significant challenge. Although gut microbiota composition may be altered by environmental variables, it is fairly stable during adulthood and old age, and the analysis of gut microbial composition is not enough to fully understand the impact of a nutritional intervention in the gut microbiota and its consequences on the brain. Novel findings suggest the need for including the analysis of the metabolome and specific biomarkers of the microbial metabolism for the understanding of the effect of nutritional interventions on brain function. Summary This review explores evidences pointing towards diet having a pivotal impact on the host’s development and progression of mental disorders through the regulation of microbiota composition and functionality. It is also discussed the role of key microbial metabolites as essential biomarkers to a better understanding of the complexity of the inter-relationship between microbiota, diet, and mental health.
      PubDate: 2018-02-08
      DOI: 10.1007/s40473-018-0147-8
  • Rapid-Acting Antidepressants: Mechanistic Insights and Future Directions
    • Authors: Danielle M. Gerhard; Ronald S. Duman
      Abstract: Purpose of Review Ketamine produces rapid (within hours) antidepressant actions, even in patients considered treatment resistant, and even shows promise for suicidal ideation. Here, we review current research on the molecular and cellular mechanisms of ketamine and other novel rapid-acting antidepressants, and briefly explore gender differences in the pathophysiology and treatment of MDD. Recent Findings Ketamine, an NMDA receptor antagonist, increases BDNF release and synaptic connectivity, opposing the deficits caused by chronic stress and depression. Efforts are focused on the development of novel rapid agents that produce similar synaptic and rapid antidepressant actions, but without the side effects of ketamine. The impact of gender on the response to ketamine and other rapid-acting antidepressants is in early stages of investigation. Summary The discovery that ketamine produces rapid therapeutic actions for depression and suicidal ideation represents a major breakthrough and much needed alternative to currently available medications. However, novel fast acting agents with fewer side effects are needed, as well as elucidation of the efficacy of these rapid-acting antidepressants for depression in women.
      PubDate: 2018-02-05
      DOI: 10.1007/s40473-018-0139-8
  • Transcranial Direct Current Stimulation for the Treatment of Depression: a
           Review of the Candidate Mechanisms of Action
    • Authors: Maria Ironside; Sarah Perlo
      Abstract: Purpose of Review Numerous studies published in the last 10 years indicate that repeated administration of prefrontal transcranial direct current stimulation (tDCS) is a potential effective treatment for major depressive disorder (MDD). However, the mechanisms of action are unclear and methods of patient selection for clinical trials are limited. This review seeks to examine the potential neural and cognitive mechanisms of action of tDCS in the treatment of MDD, to aid patient selection for future clinical trials. Recent Findings Cognitive measures of tDCS efficacy in the treatment of MDD have begun to be examined over the past 5 years. Baseline measures of working memory and letter fluency have been shown to predict treatment response. In addition, tDCS reduced cognitive deficits induced by stress, suggesting a protective mechanism. Summary Baseline measures of working memory and letter fluency may aid patient selection in future clinical trials of tDCS. In addition, reduction of stress responsivity may be a key mechanism of action for tDCS in clinical groups and merits further investigation, acutely and post-treatment.
      PubDate: 2018-01-31
      DOI: 10.1007/s40473-018-0138-9
  • Intrusive Memories of Trauma in the Laboratory: Methodological
           Developments and Future Directions
    • Authors: Alex Lau-Zhu; Emily A. Holmes; Kate Porcheret
      Abstract: Purpose of the Review Intrusive memories are those that spring to mind unbidden, e.g. sensory recollections of stressful/traumatic events. We review recent methods to monitor intrusions of a stressor (a trauma film) within the laboratory. Recent Findings Recent studies suggest three main methodologies after viewing a trauma film by which to monitor intrusions in the laboratory: during post-film rest periods, after exposure to trigger cues, and while performing an ongoing task. These approaches allow factors to be tested (e.g. psychological or pharmacological) that may influence the frequency of occurrence of intrusions. Summary We raise methodological considerations to guide trauma film studies using intrusion monitoring in the laboratory to complement monitoring approaches in daily life (e.g. diaries). Intrusion monitoring in the laboratory also confers greater experimental control and may open novel research avenues, to advance intervention development to mitigate problematic intrusive memory symptoms.
      PubDate: 2018-01-31
      DOI: 10.1007/s40473-018-0141-1
  • Antisocial Personality Disorder: Neurophysiological Mechanisms and
           Distinct Subtypes
    • Authors: Sean McKinley; Christopher Patrick; Edelyn Verona
      Abstract: Purpose of Review The trait-oriented triarchic model of psychopathy emphasizes heterogeneity in mechanisms that give rise to antisocial behavior. We review findings from neurophysiological studies that provide evidence for distinct variants of antisocial personality involving different configurations of triarchic model traits—boldness, meanness, and disinhibition. Recent Findings High boldness is evident in some manifestations of ASPD, where it operates as a “mask” to conceal callous-disinhibitory proclivities. Meanness involves features of low empathy, weak affiliation, and an antagonistic social style that appear related to deficits in sensitivity to pain and distress in others. Disinhibition is associated with impairments in frontal-executive functioning manifested in deficient behavioral restraint and poor affect regulation. Summary We propose alternative subtypes of ASPD, including “primarily detached” and “primarily disinhibited” variants, with differing propensities for aggression and distinct neurophysiological profiles. Further research is needed to clarify mechanisms for these ASPD subtypes and how best to address them clinically.
      PubDate: 2018-01-25
      DOI: 10.1007/s40473-018-0142-0
  • Pathways to Neuroprediction: Opportunities and Challenges to Prediction of
           Treatment Response in Depression
    • Authors: Scott A. Langenecker; Natania A. Crane; Lisanne M. Jenkins; K. Luan Phan; Heide Klumpp
      Abstract: Purpose of Review We set out to review the current state of science in neuroprediction, using biological measures of brain function, with task based fMRI to prospectively predict response to a variety of treatments. Recent Findings Task-based fMRI neuroprediction studies are balanced between whole brain and ROI specific analyses. The predominant tasks are emotion processing, with ROIs based upon amygdala and subgenual anterior cingulate gyrus, both within the salience and emotion network. A rapidly emerging new area of neuroprediction is of disease course and illness recurrence. Concerns include use of open-label and single arm studies, lack of consideration of placebo effects, unbalanced adjustments for multiple comparisons (over focus on type I error), small sample sizes, unreported effect sizes, overreliance on ROI studies. Summary There is a need to adjust neuroprediction study reporting so that greater coherence can facilitate meta analyses, and increased funding for more multiarm studies in neuroprediction.
      PubDate: 2018-01-24
      DOI: 10.1007/s40473-018-0140-2
  • Microbes Tickling Your Tummy: the Importance of the Gut-Brain Axis in
           Parkinson’s Disease
    • Authors: Paula Perez-Pardo; Mitch Hartog; Johan Garssen; Aletta D. Kraneveld
      Abstract: Purpose of Review Patients suffering from Parkinson’s disease (PD) are known to experience gastrointestinal dysfunction that might precede the onset of motor symptoms by several years. Evidence suggests an important role of the gut-brain axis in PD pathogenesis. These interactions might be essentially influenced by the gut microbiota. Here, we review recent findings supporting that changes in the gut microbiota composition might be a trigger for inflammation contributing to neurodegeneration in PD. Recent Findings Recent research revealed that PD patients exhibit a pro-inflammatory microbiota profile in their intestinal tract that might increase gut permeability, allowing leakage of bacterial products and inflammatory mediators from the intestines. Evidence in literature indicates that alpha-synuclein deposition might start in the enteric nervous system by pro-inflammatory immune activity and then propagates to the CNS. Alternatively, the peripheral inflammatory response could impact the brain through systemic mechanisms. Summary A better understanding of the gut-brain interactions and the role of the intestinal microbiota in the regulation of immune responses might bring new insights in PD pathological progression and might lead to novel diagnostics and therapeutic approaches.
      PubDate: 2017-11-08
      DOI: 10.1007/s40473-017-0129-2
  • Vascular Contributions to Late Life Depression
    • Authors: Joon Hyuk Park
      Abstract: Purpose of Review This review aims to examine the current evidence for vascular contributions to late life depression (LLD). Recent Findings White matter hyperintensities (WMHs) are very common in the elderly. Greater WMH severity is consistently associated with LLD. High levels of endothelial plasma soluble intercellular adhesion molecule-1, indicating vascular endothelial dysfunction, are associated with LLD. Chronic ischemic lesions, which are visualized as WMHs on T2-weighted or fluid-attenuated inversion recovery image of MRI, may disrupt frontal-subcortical-limbic networks. These disruptions can then be detected on diffusion tensor imaging. Vascular diseases (stroke, cardiovascular disease, diabetes mellitus, and homocysteinemia) and hemodynamic dysfunction are also established risk factors for LLD. Summary Convergent evidence indicates that vascular depression is a useful construct accounting for vascular contributions to LLD. Comprehensive understanding of vascular contributions to LLD will not only inform preventive strategies for LLD but also provide guidance on developing innovative treatments for ameliorating specific vascular risk factors.
      PubDate: 2017-11-02
      DOI: 10.1007/s40473-017-0128-3
  • Roles of Inflammation and Depression in the Development of Gestational
    • Authors: Thalia K. Robakis; Linn Aasly; Katherine Ellie Williams; Claire Clark; Natalie L. Rasgon
      Abstract: Objective The purpose of this review was to critically assess the available data regarding associations between inflammation and symptoms of depression among perinatal women, and to explore whether there is support for the hypothesis that inflammation associated with depression can represent a precipitating insult for the development of gestational diabetes, a known inflammatory morbidity of pregnancy. Methods Primary data papers that explored associations between inflammatory biomarkers and depressive symptoms in perinatal women were obtained via targeted searches of PubMed and Google Scholar, and via citations within relevant data papers and review articles. Results Twenty primary data papers were found that attempted to associate levels of inflammatory biomarkers with depressive symptomatology in the perinatal period. Results from these papers were heterogeneous and did not describe a reproducible inflammatory profile of perinatal depression. Conclusions Depression in the perinatal period is a common disorder; however, available data do not indicate that there is a specific inflammatory picture associated with perinatal depression. We suggest that perinatal depression may be a heterogeneous construct, and that inflammation may be relevant to it in the context of other inflammatory morbidities of pregnancy. There is some circumstantial support for the hypothesis that inflammation associated with depression may contribute to risk for gestational diabetes, but as yet, no direct tests of this hypothesis have been published.
      PubDate: 2017-10-28
      DOI: 10.1007/s40473-017-0131-8
  • Developing Repetitive Transcranial Magnetic Stimulation (rTMS) as a
           Treatment Tool for Cocaine Use Disorder: a Series of Six Translational
    • Authors: Colleen A. Hanlon; Tonisha Kearney-Ramos; Logan T. Dowdle; Sarah Hamilton; William DeVries; Oliver Mithoefer; Christopher Austelle; Daniel H. Lench; Brittany Correia; Melanie Canterberry; Joshua P. Smith; Kathleen T. Brady; Mark S. George
      Abstract: Purpose of the Review Cocaine dependence is a chronic and relapsing disorder which is particularly resistant to behavioral or pharmacologic treatment, and likely involves multiple dysfunctional frontal-striatal circuits. Through advances in preclinical research in the last decade, we now have an unprecedented understanding of the neural control of drug-taking behavior. In both rodent models and human clinical neuroimaging studies, it is apparent that medial frontal-striatal limbic circuits regulate drug cue-triggered behavior. While non-human preclinical studies can use invasive stimulation techniques to inhibit drug cue-evoked behavior, in human clinical neuroscience, we are pursuing non-invasive theta burst stimulation (TBS) as a novel therapeutic tool to inhibit drug cue-associated behavior. Recent Findings Our laboratory and others have spent the last 7 years systematically and empirically developing a non-invasive, neural circuit-based intervention for cocaine use disorder. Utilizing a multimodal approach of functional brain imaging and brain stimulation, we have attempted to design and optimize a repetitive transcranial magnetic stimulation treatment protocol for cocaine use disorder. This manuscript will briefly review the data largely from our own lab that motivated our selection of candidate neural circuits, and then summarize the results of six studies, culminating in the first double-blinded, sham-controlled clinical trial of TMS as a treatment adjuvant for treatment-engaged cocaine users (10 sessions, medial prefrontal cortex, 110% resting motor threshold, continuous theta burst stimulation, 3600 pulses/session). Summary The intent of this review is to highlight one example of a systematic path for TMS treatment development in patients. This path is not necessarily optimal, exclusive, or appropriate for every neurologic or psychiatric disease. Rather, it is one example of a reasoned, empirically derived pathway which we hope will serve as scaffolding for future investigators seeking to develop TMS treatment protocols.
      PubDate: 2017-10-23
      DOI: 10.1007/s40473-017-0135-4
  • You Need Guts to Make New Neurons
    • Authors: Susanne A. Wolf; Daniele Mattei
      Abstract: Purpose of the Review In the present review, we discuss the very recent findings that the gut microbiota composition can modulate cell-based plasticity in the brain, namely, adult hippocampal neurogenesis, and thereby alter hippocampal dependent behavior. Recent Findings Absence of gut microbiota from birth or antibiotic-induced dysbiosis in adults leads to an aberrant metabolite production and immune functions. Both scenarios compromise a proper postnatal brain development, or brain wiring in adults, including aberrant neurogenesis. This in turn leads to a hippocampal mismanagement of environmental cues and renders the animals to be more susceptible to stress and less cognitively flexible which contribute to general impairments in learning and memory functions and social behavior. Summary Mounting evidence indicates that certain behavior aberrances in germ-free and dysbiotic mice are mediated by changes in neurogenesis. The mechanisms and the relevance of this complex regulation remain to be elucidated by future research.
      PubDate: 2017-10-12
      DOI: 10.1007/s40473-017-0127-4
  • What Effect Does tDCS Have on the Brain' Basic Physiology of tDCS
    • Authors: Asif Jamil; Michael A. Nitsche
      Abstract: Purpose of the Review Transcranial direct current stimulation (tDCS) can effectively modulate a wide range of clinical and cognitive outcomes by modulating cortical excitability. Here, we summarize the main findings from both animal and human neurophysiology literature, which have revealed mechanistic evidence for the acute and neuroplastic after-effects of tDCS. Recent Findings Insights into the magnitude and geometric orientation of transcranially induced currents have been provided by the combination of computational modeling of current flow in animal slice preparations and intracranial recordings in humans. In addition to its synaptic effects, stimulation also induces after-effects on the glial and vascular systems, the latter also observed in humans by magnetic resonance imaging. Several studies have also observed non-linear or antagonistic effects of tDCS parameters, which warrants further systematic studies to explore and understand the basic mechanisms. Summary tDCS is a valuable and promising technique across the neurophysiological, cognitive neuroscience, and clinical domains of research. Primary and secondary effects of tDCS still remain to be completely understood. An important challenge for the field is advancing tDCS protocols forward for optimal intervention and treatment strategies.
      PubDate: 2017-10-09
      DOI: 10.1007/s40473-017-0134-5
  • The Nature of the Relationship Between Anxiety and the Error-Related
           Negativity Across Development
    • Authors: Jason S. Moser
      Abstract: Purpose of Review I review the literature on the relationship between anxiety and the error-related negativity (ERN), a neurophysiological marker of performance monitoring, across development. I cover the development of the ERN, its functional significance, and its different relationship with anxiety in young children compared to adolescents and adults. Recent Findings Contemporary research indicates that the ERN becomes larger with age and shows primary sources in cingulate, frontal, and motor cortices. Functional accounts of the ERN and its relationship with anxiety emphasize either cognitive control or affective mechanisms. Converging evidence across development suggests a reduced ERN characterizes anxious young children whereas an enlarged ERN characterizes older children, adolescents, and adults. Summary The mechanisms involved in the developmental change in the relationship between the ERN and anxiety have important implications for better understanding interactions between cognitive control, anxiety, and motivation across the life span. Further research is needed to address extant methodological limitations and make stronger links to related neuroscience findings and theory on the development of anxiety and self-control.
      PubDate: 2017-09-30
      DOI: 10.1007/s40473-017-0132-7
  • Vascular Endothelial Growth Factor (VEGF) in Neurodevelopmental Disorders
    • Authors: Kristy R. Howell; Jennifer Armstrong
      Abstract: Purpose of the Review Neurovascular dysfunction and the role of vascular endothelial growth factor (VEGF) have been explored in neurodevelopmental disorders including schizophrenia, bipolar disorder, major depressive and mood disorders, and autism. These disorders are correlated with hypoxia-ischemia insults during early life and are strongly associated with cognitive dysfunction. This review focuses on the hypoxia-regulated protein, VEGF, to discuss its crucial roles in brain development and function. These data implicate that alterations to VEGF signaling during early life can impair neural development, underlying the severe cognitive deficits observed in neurodevelopmental disorders. Recent Findings VEGF has been linked to neurological processes that influence learning and memory. VEGF is advancing towards being a novel biomarker and possible therapeutic for neurological disorders. Prenatal environmental enrichment positively impacted neurotrophic factors, brain structure, and memory in rodent models. Summary Understanding the molecular mechanisms of VEGF in neurodevelopment will create intervention strategies for at-risk children born to adverse early-life events. By proactively working with those in a pliable neurodevelopmental state, we hope to ameliorate cognitive deficits to increase their chance to develop into high-functioning adults with disabilities.
      PubDate: 2017-09-30
      DOI: 10.1007/s40473-017-0130-9
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