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  Subjects -> PSYCHOLOGY (Total: 871 journals)
Showing 1 - 174 of 174 Journals sorted alphabetically
Acción Psicológica     Open Access   (Followers: 2)
Acta Colombiana de Psicología     Open Access   (Followers: 4)
Acta Comportamentalia     Open Access   (Followers: 3)
Acta de Investigación Psicológica     Open Access   (Followers: 2)
Acta Psychologica     Hybrid Journal   (Followers: 21)
Activités     Open Access   (Followers: 1)
Actualidades en Psicologia     Open Access   (Followers: 1)
Ad verba Liberorum : Journal of Linguistics & Pedagogy & Psychology     Open Access   (Followers: 8)
Addictive Behaviors Reports     Open Access   (Followers: 5)
ADHD Attention Deficit and Hyperactivity Disorders     Hybrid Journal   (Followers: 20)
ADHD Report The     Full-text available via subscription   (Followers: 6)
Advances in Experimental Social Psychology     Full-text available via subscription   (Followers: 38)
Advances in Mental Health     Hybrid Journal   (Followers: 68)
Advances in Physiotherapy     Hybrid Journal   (Followers: 50)
Advances in Psychology     Full-text available via subscription   (Followers: 56)
Advances in the Study of Behavior     Full-text available via subscription   (Followers: 28)
African Journal of Cross-Cultural Psychology and Sport Facilitation     Full-text available via subscription   (Followers: 3)
Aggression and Violent Behavior     Hybrid Journal   (Followers: 389)
Aggressive Behavior     Hybrid Journal   (Followers: 17)
Aging, Neuropsychology, and Cognition     Hybrid Journal   (Followers: 33)
Ágora - studies in psychoanalytic theory     Open Access   (Followers: 3)
Aletheia     Open Access   (Followers: 1)
American Behavioral Scientist     Hybrid Journal   (Followers: 15)
American Imago     Full-text available via subscription   (Followers: 3)
American Journal of Applied Psychology     Open Access   (Followers: 33)
American Journal of Community Psychology     Hybrid Journal   (Followers: 24)
American Journal of Health Behavior     Full-text available via subscription   (Followers: 23)
American Journal of Orthopsychiatry     Hybrid Journal   (Followers: 4)
American Journal of Psychoanalysis     Hybrid Journal   (Followers: 21)
American Journal of Psychotherapy     Full-text available via subscription   (Followers: 33)
American Psychologist     Full-text available via subscription   (Followers: 160)
Anales de Psicología     Open Access   (Followers: 2)
Análise Psicológica     Open Access   (Followers: 1)
Análisis y Modificación de Conducta     Open Access   (Followers: 2)
Analysis     Full-text available via subscription   (Followers: 4)
Annual Review of Clinical Psychology     Full-text available via subscription   (Followers: 66)
Annual Review of Organizational Psychology and Organizational Behavior     Full-text available via subscription   (Followers: 25)
Annual Review of Psychology     Full-text available via subscription   (Followers: 195)
Anuario de Psicología / The UB Journal of Psychology     Open Access   (Followers: 1)
Anuario de Psicología Jurídica     Open Access   (Followers: 1)
Anxiety, Stress & Coping: An International Journal     Hybrid Journal   (Followers: 22)
Applied and Preventive Psychology     Hybrid Journal   (Followers: 13)
Applied Cognitive Psychology     Hybrid Journal   (Followers: 65)
Applied Neuropsychology : Adult     Hybrid Journal   (Followers: 32)
Applied Neuropsychology : Child     Hybrid Journal   (Followers: 18)
Applied Psychological Measurement     Hybrid Journal   (Followers: 17)
Applied Psychology     Hybrid Journal   (Followers: 125)
Applied Psychology: Health and Well-Being     Hybrid Journal   (Followers: 48)
Applied Psychophysiology and Biofeedback     Hybrid Journal   (Followers: 6)
Archive for the Psychology of Religion / Archiv für Religionspychologie     Hybrid Journal   (Followers: 16)
Archives of Clinical Neuropsychology     Hybrid Journal   (Followers: 26)
Archives of Scientific Psychology     Open Access   (Followers: 3)
Arquivos Brasileiros de Psicologia     Open Access   (Followers: 1)
Asia Pacific Journal of Counselling and Psychotherapy     Hybrid Journal   (Followers: 8)
Asia-Pacific Psychiatry     Hybrid Journal   (Followers: 3)
Asian American Journal of Psychology     Full-text available via subscription   (Followers: 5)
Asian Journal of Business Ethics     Hybrid Journal   (Followers: 7)
Assessment     Hybrid Journal   (Followers: 9)
At-Tajdid : Jurnal Ilmu Tarbiyah     Open Access   (Followers: 2)
Attachment: New Directions in Psychotherapy and Relational Psychoanalysis     Full-text available via subscription   (Followers: 16)
Attention, Perception & Psychophysics     Full-text available via subscription   (Followers: 10)
Australian and Aotearoa New Zealand Psychodrama Association Journal     Full-text available via subscription  
Australian Educational and Developmental Psychologist, The     Full-text available via subscription   (Followers: 6)
Australian Journal of Psychology     Hybrid Journal   (Followers: 16)
Australian Psychologist     Hybrid Journal   (Followers: 11)
Autism Research     Hybrid Journal   (Followers: 31)
Autism Research and Treatment     Open Access   (Followers: 29)
Autism's Own     Open Access  
Autism-Open Access     Open Access   (Followers: 5)
Avaliação Psicológica     Open Access  
Avances en Psicologia Latinoamericana     Open Access   (Followers: 1)
Aviation Psychology and Applied Human Factors     Hybrid Journal   (Followers: 17)
Balint Journal     Hybrid Journal   (Followers: 3)
Barbaroi     Open Access  
Basic and Applied Social Psychology     Hybrid Journal   (Followers: 31)
Behavior Analysis in Practice     Full-text available via subscription   (Followers: 6)
Behavior Analysis: Research and Practice     Full-text available via subscription   (Followers: 2)
Behavior Analyst     Hybrid Journal   (Followers: 3)
Behavior Modification     Hybrid Journal   (Followers: 9)
Behavior Research Methods     Hybrid Journal   (Followers: 17)
Behavior Therapy     Hybrid Journal   (Followers: 45)
Behavioral Development Bulletin     Full-text available via subscription  
Behavioral Interventions     Hybrid Journal   (Followers: 7)
Behavioral Neuroscience     Full-text available via subscription   (Followers: 49)
Behavioral Sciences & the Law     Hybrid Journal   (Followers: 20)
Behavioral Sleep Medicine     Hybrid Journal   (Followers: 6)
Behaviour     Hybrid Journal   (Followers: 13)
Behaviour Research and Therapy     Hybrid Journal   (Followers: 17)
Behavioural and Cognitive Psychotherapy     Hybrid Journal   (Followers: 110)
Behavioural Processes     Hybrid Journal   (Followers: 6)
Biofeedback     Hybrid Journal   (Followers: 4)
BioPsychoSocial Medicine     Open Access   (Followers: 6)
BMC Psychology     Open Access   (Followers: 15)
Body, Movement and Dance in Psychotherapy: An International Journal for Theory, Research and Practice     Hybrid Journal   (Followers: 9)
Boletim Academia Paulista de Psicologia     Open Access  
Boletim de Psicologia     Open Access  
Brain Informatics     Open Access   (Followers: 1)
British Journal of Clinical Psychology     Full-text available via subscription   (Followers: 122)
British Journal of Developmental Psychology     Full-text available via subscription   (Followers: 35)
British Journal of Educational Psychology     Hybrid Journal   (Followers: 31)
British Journal of Health Psychology     Full-text available via subscription   (Followers: 42)
British Journal of Mathematical and Statistical Psychology     Full-text available via subscription   (Followers: 19)
British Journal of Psychology     Full-text available via subscription   (Followers: 56)
British Journal of Psychotherapy     Hybrid Journal   (Followers: 66)
British Journal of Social Psychology     Full-text available via subscription   (Followers: 31)
Burnout Research     Open Access   (Followers: 7)
Cadernos de psicanálise (Rio de Janeiro)     Open Access  
Cadernos de Psicologia Social do Trabalho     Open Access  
Canadian Art Therapy Association     Hybrid Journal  
Canadian Journal of Behavioural Science     Full-text available via subscription   (Followers: 6)
Canadian Journal of Experimental Psychology     Full-text available via subscription   (Followers: 11)
Canadian Psychology / Psychologie canadienne     Full-text available via subscription   (Followers: 10)
Cendekia : Jurnal Kependidikan dan Kemasyarakatan     Open Access  
Child Development Perspectives     Hybrid Journal   (Followers: 26)
Child Development Research     Open Access   (Followers: 13)
Ciencia Cognitiva     Open Access   (Followers: 2)
Ciencia e Interculturalidad     Open Access  
Ciências & Cognição     Open Access  
Ciencias Psicológicas     Open Access  
Clínica y Salud     Open Access  
Clinical Medicine Insights : Psychiatry     Open Access   (Followers: 9)
Clinical Practice in Pediatric Psychology     Full-text available via subscription   (Followers: 10)
Clinical Psychological Science     Hybrid Journal   (Followers: 11)
Clinical Psychologist     Hybrid Journal   (Followers: 15)
Clinical Psychology & Psychotherapy     Hybrid Journal   (Followers: 67)
Clinical Psychology and Special Education     Open Access   (Followers: 1)
Clinical Psychology Review     Hybrid Journal   (Followers: 33)
Clinical Psychology: Science and Practice     Hybrid Journal   (Followers: 20)
Clinical Schizophrenia & Related Psychoses     Full-text available via subscription   (Followers: 8)
Coaching Psykologi - The Danish Journal of Coaching Psychology     Open Access   (Followers: 1)
Cogent Psychology     Open Access  
Cógito     Open Access  
Cognition & Emotion     Hybrid Journal   (Followers: 36)
Cognitive Behaviour Therapy     Hybrid Journal   (Followers: 14)
Cognitive Neuropsychology     Hybrid Journal   (Followers: 26)
Cognitive Psychology     Hybrid Journal   (Followers: 58)
Consciousness and Cognition     Hybrid Journal   (Followers: 26)
Construção Psicopedagógica     Open Access  
Consulting Psychology Journal : Practice and Research     Full-text available via subscription   (Followers: 3)
Contagion : Journal of Violence, Mimesis, and Culture     Full-text available via subscription   (Followers: 8)
Contemporary Educational Psychology     Hybrid Journal   (Followers: 21)
Contemporary School Psychology     Hybrid Journal   (Followers: 4)
Contextos Clínicos     Open Access  
Counseling Outcome Research and Evaluation     Hybrid Journal   (Followers: 10)
Counseling Psychologist     Hybrid Journal   (Followers: 14)
Counseling Psychology and Psychotherapy     Open Access   (Followers: 7)
Counselling and Psychotherapy Research : Linking research with practice     Hybrid Journal   (Followers: 19)
Counselling and Values     Hybrid Journal   (Followers: 2)
Counselling Psychology Quarterly     Hybrid Journal   (Followers: 10)
Couple and Family Psychoanalysis     Full-text available via subscription   (Followers: 1)
Couple and Family Psychology : Research and Practice     Full-text available via subscription   (Followers: 4)
Creativity Research Journal     Hybrid Journal   (Followers: 20)
Creativity. Theories - Research - Applications     Open Access   (Followers: 1)
Criminal Justice Ethics     Hybrid Journal   (Followers: 7)
Cuadernos de Neuropsicología     Open Access   (Followers: 1)
Cuadernos de Psicologia del Deporte     Open Access  
Cuadernos de Psicopedagogía     Open Access  
Cultural Diversity and Ethnic Minority Psychology     Full-text available via subscription   (Followers: 12)
Cultural-Historical Psychology     Open Access  
Culturas Psi     Open Access  
Culture and Brain     Hybrid Journal   (Followers: 3)
Current Addiction Reports     Hybrid Journal   (Followers: 9)
Current Behavioral Neuroscience Reports     Hybrid Journal   (Followers: 2)
Current Directions In Psychological Science     Hybrid Journal   (Followers: 46)
Current Opinion in Behavioral Sciences     Hybrid Journal   (Followers: 1)
Current Opinion in Psychology     Hybrid Journal   (Followers: 3)
Current Psychological Research     Hybrid Journal   (Followers: 13)
Current Psychology     Hybrid Journal   (Followers: 14)
Current psychology letters     Open Access   (Followers: 2)
Current Research in Psychology     Open Access   (Followers: 20)
Cyberpsychology, Behavior, and Social Networking     Hybrid Journal   (Followers: 14)
Decision     Full-text available via subscription   (Followers: 2)
Depression and Anxiety     Hybrid Journal   (Followers: 14)
Depression Research and Treatment     Open Access   (Followers: 13)
Developmental Cognitive Neuroscience     Open Access   (Followers: 16)
Developmental Neuropsychology     Hybrid Journal   (Followers: 15)
Developmental Psychobiology     Hybrid Journal   (Followers: 9)
Developmental Psychology     Full-text available via subscription   (Followers: 44)
Diagnostica     Hybrid Journal   (Followers: 2)
Dialectica     Hybrid Journal   (Followers: 1)
Discourse     Full-text available via subscription   (Followers: 8)
Diversitas: Perspectivas en Psicologia     Open Access  
Drama Therapy Review     Hybrid Journal   (Followers: 1)
Dreaming     Full-text available via subscription   (Followers: 11)
Drogues, santé et société     Full-text available via subscription  
Dynamics of Asymmetric Conflict: Pathways toward terrorism and genocide     Hybrid Journal   (Followers: 12)
E-Journal of Applied Psychology     Open Access   (Followers: 7)
Ecopsychology     Hybrid Journal   (Followers: 6)
ECOS - Estudos Contemporâneos da Subjetividade     Open Access  
Educational Psychology Review     Hybrid Journal   (Followers: 25)
Educational Psychology: An International Journal of Experimental Educational Psychology     Hybrid Journal   (Followers: 46)
Educazione sentimentale     Full-text available via subscription  
Electronic Journal of Research in Educational Psychology     Open Access   (Followers: 6)
Elpis - Czasopismo Teologiczne Katedry Teologii Prawosławnej Uniwersytetu w Białymstoku     Open Access  
Emotion     Full-text available via subscription   (Followers: 33)
Emotion Review     Hybrid Journal   (Followers: 17)
En-Claves del pensamiento     Open Access   (Followers: 1)
Enseñanza e Investigacion en Psicologia     Open Access  
Epiphany     Open Access   (Followers: 3)
Escritos de Psicología : Psychological Writings     Open Access   (Followers: 2)

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Journal Cover Current Behavioral Neuroscience Reports
  [2 followers]  Follow
    
   Hybrid Journal Hybrid journal (It can contain Open Access articles)
   ISSN (Online) 2196-2979
   Published by Springer-Verlag Homepage  [2340 journals]
  • Using New Approaches in Neurobiology to Rethink Stress-Induced Amnesia
    • Authors: Jelena Radulovic
      Abstract: Purpose of Review Psychological stress can impact memory systems in several different ways. In individuals with healthy defense and coping systems, stress results in the formation of negatively valenced memories whose ability to induce emotional and somatic distress subsides with time. Vulnerable individuals, however, go on to develop stress-related disorders such as post-traumatic stress disorder (PTSD) and suffer from significant memory abnormalities. Whether expressed as intrusive trauma memories, partial amnesia, or dissociative amnesia, such abnormalities are thought to be the core source of patients’ symptoms, which are often debilitating and implicate an entire socio-cognitive-affective spectrum. Recent Findings With this in mind, and focusing on stress-responsive hippocampal microcircuits, this article highlights recent advances in the neurobiology of memory that allow us to (1) isolate and visualize memory circuits, (2) change their activity using genetic tools and state-dependent manipulations, and (3) directly examine their impact on socio-affective circuits and global network connectivity. By integrating these approaches, we are now in a position to address important questions that have troubled psychiatry for a long time—questions such as are traumatic memories special, and why are stress effects on memory diverse. Summary Furthering our fundamental understanding of memory in the framework of adaptive and maladaptive stress responses has the potential to boost the development of new treatments that can benefit patients suffering from psychological trauma.
      PubDate: 2017-02-21
      DOI: 10.1007/s40473-017-0109-6
       
  • The Psychosocial Aspects of the Gilles de la Tourette Syndrome: Empirical
           Evidence from the Literature
    • Authors: Mary May Robertson; Valsamma Eapen
      Abstract: Objective A literature review suggests that Gilles de la Tourette syndrome (GTS) is common but under-diagnosed and under-reported, and the consequences and impact are not fully understood. This review is focussed on the adverse psychosocial consequences experienced by many GTS patients which, in turn, cause significant distress and disadvantage to both the patients and their families. Method A review of the literature was conducted using Pubmed and Medline under the headings Tourette, psychosocial, stigma, stress and suicide, and also, cross-references were made from relevant sources based on the authors’ experience in the field. Results Many of the difficulties of GTS are experienced within the individual (the “inner sensations”), but some are due to the loud vocal tics as well as socially stigmatising nature of some of the motor tics (e.g. spitting) and the “possibly offensive” copropraxia. In other instances, this may be linked to the co-morbidity (e.g. ADHD, OCD) and co-existing psychopathology (e.g. depression, conduct disorder) that occur in up to 90% of people with GTS. More quantitative research into the psychosocial aspects and sequelae of having GTS are suggested. Conclusions Apart from managing and treating the individual with GTS in a comprehensive way, the education of the general public, teachers, doctors and employers is of vital importance to improve the psychosocial aspects of the person with GTS.
      PubDate: 2017-02-09
      DOI: 10.1007/s40473-017-0107-8
       
  • Network-Guided Transcranial Magnetic Stimulation for Depression
    • Authors: Marc J. Dubin; Conor Liston; Michael A. Avissar; Irena Ilieva; Faith M. Gunning
      Abstract: Purpose of Review First, we will identify candidate predictive biomarkers of antidepressant response of TMS based on the neuroimaging literature. Next, we will review the effects of TMS on networks involved in depression. Finally, we will discuss ways in which our current understanding of network engagement by TMS may be used to optimize its antidepressant effect. Recent Findings The past few years has seen significant interest in the antidepressant mechanisms of TMS. Studies using functional neuroimaging and neurochemical imaging have demonstrated engagement of networks known to be important in depression. Current evidence supports a model whereby TMS normalizes network function gradually over the course of several treatments. This may, in turn, mediate its antidepressant effect. Summary One strategy to optimize the antidepressant effect of TMS is to more precisely target networks relevant in depression. We propose methods to achieve this using functional and neurochemical imaging.
      PubDate: 2017-02-07
      DOI: 10.1007/s40473-017-0108-7
       
  • Computational Psychiatry in Borderline Personality Disorder
    • Authors: Sarah K Fineberg; Dylan S Stahl; Philip R Corlett
      Abstract: Purpose of Review We review the literature on the use and potential use of computational psychiatry methods in borderline personality disorder. Recent Findings Computational approaches have been used in psychiatry to increase our understanding of the molecular, circuit, and behavioral basis of mental illness. This is of particular interest in BPD, where the collection of ecologically valid data, especially in interpersonal settings, is becoming more common and more often subject to quantification. Methods that test learning and memory in social contexts, collect data from real-world settings, and relate behavior to molecular and circuit networks are yielding data of particular interest. Summary Research in BPD should focus on collaborative efforts to design and interpret experiments with direct relevance to core BPD symptoms and potential for translation to the clinic.
      PubDate: 2017-02-04
      DOI: 10.1007/s40473-017-0104-y
       
  • Monoamine Oxidase A in Antisocial Personality Disorder and Borderline
           Personality Disorder
    • Authors: Nathan J. Kolla; Sarah A. Vinette
      Abstract: Purpose of Review Variation in the monoamine oxidase A (MAO-A) gene and MAO-A enzyme levels have been linked to antisocial behavior and aggression in clinical and non-clinical populations. Here, we provide an overview of the genetic, epigenetic, and neuroimaging research that has examined MAO-A structure and function in antisocial personality disorder (ASPD) and borderline personality disorder (BPD). Recent Findings The low-activity MAO-A variable nucleotide tandem repeat genetic polymorphism has shown a robust association with large samples of violent and seriously violent offenders, many of whom had ASPD. A recent positron emission tomography (PET) study of ASPD similarly revealed low MAO-A density in brain regions thought to contribute to the psychopathology of the condition. By contrast, PET has also demonstrated that brain MAO-A levels are increased in BPD and that they relate to symptoms of low mood and suicidality. Summary Candidate gene studies have produced the most compelling evidence connecting MAO-A genetic variants to both ASPD and BPD. Still, conflicting results abound in the literature, making it highly unlikely that ASPD or BPD is related to a specific MAO-A genetic variant. Future research should strive to examine how MAO-A genotypes interact with broad-spectrum environmental influences to produce brain endophenotypes that may ultimately become tractable targets for novel treatment strategies.
      PubDate: 2017-02-03
      DOI: 10.1007/s40473-017-0102-0
       
  • What Works in the Treatment of Borderline Personality Disorder
    • Authors: Lois W. Choi-Kain; Ellen F. Finch; Sara R. Masland; James A. Jenkins; Brandon T. Unruh
      Abstract: Purpose of the Review This review summarizes advances in treatments for adults with borderline personality disorder (BPD) in the last 5 years. Recent Findings Evidence-based advances in the treatment of BPD include a delineation of generalist models of care in contrast to specialist treatments, identification of essential effective elements of dialectical behavioral therapy (DBT), and the adaptation of DBT treatment to manage PTSD and BPD. Studies on pharmacological interventions remain limited and have not provided evidence that any specific medications can provide stand-alone treatment. Summary The research on treatment in BPD is leading to a distillation of intensive packages of treatment to be more broadly and practically implemented in most treatment environments through generalist care models and pared down forms of intensive treatments (e.g., informed case management plus DBT skills training groups). Evidence-based integrations of DBT and exposure therapy for PTSD provide support for changing practices to simultaneously treat PTSD and BPD.
      PubDate: 2017-02-03
      DOI: 10.1007/s40473-017-0103-z
       
  • Using Genetics to Improve Addiction Treatment Outcomes
    • Authors: Cheyenne Allenby; Mary Falcone
      Abstract: Purpose of Review This review will discuss recent studies that have employed pharmacogenetic findings to advance development of therapeutics and improve treatment outcomes for substance use disorder. Recent Findings Pharmacogenetic studies have inspired new treatment targets for smoking cessation, with mixed results. Promising initial evidence that mu-opioid receptor genotype (OPRM1 A118G) was associated with response to naltrexone treatment for alcohol dependence has not been supported in prospective trials. The nicotine metabolite ratio (NMR) may be useful for predicting response to smoking cessation treatment. Candidate gene studies suggest several genes that may identify responders for cocaine or opiate pharmacotherapy, but these studies require replication. Summary Significant progress has been made in pharmacogenetics studies of addiction treatment; however, efforts must be made to bridge the translational gap. Robust prospective studies are needed in order to gather sufficient information on the clinical utility of pharmacogenetic testing prior to implementation in a clinical setting.
      PubDate: 2017-01-30
      DOI: 10.1007/s40473-017-0106-9
       
  • Neurocognitive Function as a Treatment Target for Tobacco Use Disorder
    • Authors: Cendrine D. Robinson; Andrew J. Waters; Nicole Kang; Mehmet Sofuoglu
      Abstract: Purpose of Review Novel approaches are needed to improve the treatment of tobacco use disorder (TUD). Two distinct literatures have examined the impact of cognitive function in the maintenance of TUD. One approach has focused on automatic cognitive processes, and the second approach has addressed the role of executive cognitive processes. This review focuses on interventions that target automatic and cognitive processes for TUD. Recent Findings There appears to be evidence that attention re-training (AR) reduces automatic cognitions, but the effect on smoking requires further research. Several medications including varenicline, bupropion, and galantamine can improve executive processes and potentially reduce craving and smoking. However, whether the beneficial effects of these medications are mediated by cognitive improvement remains to be determined. Other strategies including the approach-avoidance task, transcranial direct current stimulation, and exercise require further study. Summary Most research focuses on targeting automatic and controlled cognitive processes, separately in relatively small samples. Future research should consider targeting both processes simultaneously.
      PubDate: 2017-01-30
      DOI: 10.1007/s40473-017-0105-x
       
  • The Current Understanding of Premonitory Urge Phenomena in Chronic Tic
           Disorders
    • Authors: Jeremy M. Raines; Matt W. Specht
      Abstract: Purpose of Review The goal of this review is to collect the progress made in the area of premonitory urge research in the areas of demographics, psychometrics, neurologic, psychopharmacology, and behavioral psychotherapy. Recent Findings Individuals with no previous treatment for tics have differing levels of control over their ability to suppress tics. It is unclear if tic suppression reliably causes predictable and uniform changes in urge severity. The literature is unclear regarding the role of comorbid psychological conditions with respect to urge severity. Comprehensive Behavioral Intervention for Tics (CBIT) and several pharmacological treatments have shown decreases in tic severity but it is not clear if there are corresponding decreases in urge severity. Summary Premonitory urges are prevalent sensations reported by individuals with tic disorders prior to the completion of a tic. Although there has been a recent increase in research on this topic over the past decade, several issues regarding the nature of urges remain ambiguous or in contention. Here, the authors have compiled a brief review of the literature which directly addresses current day understanding of premonitory urges.
      PubDate: 2016-11-08
      DOI: 10.1007/s40473-016-0099-9
       
  • Modeling Brain Development Using Human Cells for the Study and Treatment
           of Zika Virus Infections
    • Abstract: Purpose of Review Cellular reprogramming now permits the generation of a renewable source of disease-relevant human cells for modeling biological systems and for high-throughput drug screening. Advances in modeling human brain development to study Zika infections and its association with microcephaly are discussed in this commentary. Recent Findings Human-induced pluripotent stem cells can be differentiated to cell types similar to those in the developing brain using both 2D and 3D cell culture systems. Zika virus targets proliferating neural progenitor cells in these systems and the resultant cell death provides evidence that Zika virus infections are causal for microcephaly. Drug repurposing screens using human cells vulnerable to infection has led to the identification of antiviral and neuroprotective therapeutic candidates. Summary Together with in vivo animal models, new stem cell-based technologies to model features of the developing and mature nervous system provide a platform for accelerated drug development to combat infectious diseases with neurological consequences.
      PubDate: 2016-11-03
      DOI: 10.1007/s40473-016-0101-6
       
  • Using Placebo Response to Pain as a Predictor of Placebo Response in Mood
           Disorders
    • Authors: Sara Costi; Katherine Collins; Michael Davidson; Dan V. Iosifescu
      Abstract: Recent Findings Major depressive disorder (MDD) is the leading cause of disability worldwide and available pharmacological treatments are only partially effective. The development of new drugs is hindered by the high proportion of MDD patients who respond to placebo. Data from neuroimaging studies suggests convergence in the activation of brain circuits during placebo response to analgesia and placebo response in depression. Purpose of Review In the current work, we reviewed the published literature about placebo response in depression and in pain, focusing on the similarities within the neurobiological pathways that could facilitate identification of predictors of antidepressant placebo response. Summary Data suggests that placebo response in both pain and depression are mediated by reward neurocircuitry. The neuro-functional overlap between these networks suggests a novel strategy to prospectively identify placebo responders in MDD.
      PubDate: 2016-10-24
      DOI: 10.1007/s40473-016-0092-3
       
  • Purposeful Engagement, Healthy Aging, and the Brain
    • Authors: Carol D. Ryff; Aaron S. Heller; Stacey M. Schaefer; Carien van Reekum; Richard J. Davidson
      Abstract: Purpose of Review Research on psychological well-being in later life has identified strengths and vulnerabilities that occur with aging. We review the conceptual and philosophical foundations of a eudaimonic model of well-being and its empirical translation into six key dimensions of positive functioning. We also consider its implications for health, broadly defined. Recent Findings Numerous findings from national longitudinal samples of US adults are described. They show declining scores on purpose in life and personal growth with aging, but also underscore the notable variability among older persons in these patterns. Recently, health benefits have been identified among older adults who maintain high levels of a particular aspect of well-being, namely, purposeful life engagement. These benefits include extended longevity, reduced risk for various disease outcomes, reduced physiological dysregulation, and gene expression linked to better inflammatory profiles. The brain mechanisms that underlie such outcomes are also examined via a focus on affective style. Adults with higher levels of purpose in life show more rapid recovery from negative stimulus provocation, whereas those with higher well-being overall show sustained activation of reward circuitry in response to positive stimuli, and this pattern is associated with lower diurnal cortisol output. Volumetric findings (right insular gray matter volume) have also been linked with eudaimonic well-being. Summary Eudaimonic well-being predicts better health and longer lives, and thus constitutes an important direction for future research and practice. Intervention studies designed to promote well-being, including among those suffering from psychological disorders, are briefly described.
      PubDate: 2016-10-22
      DOI: 10.1007/s40473-016-0096-z
       
  • Mindfulness Training for Emotional and Cognitive Health in Late Life
    • Authors: Moria J. Smoski; Andrew McClintock; Lori Keeling
      Abstract: Purpose of Review There is a growing interest in psychosocial interventions that can enhance emotional and cognitive health in older adults, both to treat psychopathology and/or cognitive decline and to prolong optimum functioning in healthy individuals. Mindfulness-based interventions (MBIs) have been proposed as an accessible and effective means of promoting emotional and cognitive health. This article reviews recent clinical trials of MBIs in older adults. Recent Findings There is growing support for MBIs as a means to address mild to moderate clinical concerns, including depression, anxiety, sleep, and subjective memory or other cognitive complains but little evidence that MBIs improve functioning in already healthy individuals. Summary MBIs may be effective for older adults with mild to moderate emotional and cognitive dysfunction. Future longitudinal work is needed to test if MBIs are an effective means of prevention of emotional or cognitive decline.
      PubDate: 2016-10-14
      DOI: 10.1007/s40473-016-0097-y
       
  • Physical Exercise for Treatment of Mood Disorders: A Critical Review
    • Authors: C. M. Hearing; W. C. Chang; K. L. Szuhany; T. Deckersbach; A. A. Nierenberg; Louisa G. Sylvia
      Abstract: Purpose of the review The purpose of this review is to critically assess the evidence for exercise as an adjunct intervention for major depressive disorder and bipolar disorder, chronic conditions characterized by frequent comorbid conditions as well as interepisodic symptoms with poor quality of life and impaired functioning. Individuals with these mood disorders are at higher risk of cardiovascular disease and premature death in part because of increased rates of obesity, inactivity, and diabetes mellitus compared to the general population. Exercise may not only mitigate the increased risk of cardiovascular disease, but could also potentially improve the long term outcomes of mood disorders. Recent findings We conducted a literature review on the impact of exercise on mood disorders and associated comorbid conditions as well as possible biological mechanisms. We found that exercise impacts both the physical health parameters of mood disorders as well as mental health outcomes. Exercise also positively impacts conditions frequently comorbid with mood disorders (i.e. anxiety, pain, and insomnia). There are multiple candidate biomarkers for exercise, with brain-derived neurotrophic factor and oxidative stress as two main promising components of exercise’s anti-depressant effect. Summary Exercise appears to be a promising adjunct treatment for mood disorders. We conclude with recommendations for future research of exercise as an adjunct intervention for mood disorders.
      PubDate: 2016-10-14
      DOI: 10.1007/s40473-016-0089-y
       
  • Using Induced Pluripotent Stem Cells to Investigate Complex Genetic
           Psychiatric Disorders
    • Authors: Stephanie J. Temme; Brady J. Maher; Kimberly M. Christian
      Abstract: Purpose of Review Induced pluripotent stem cells (iPSCs) can be generated from human patient tissue samples, differentiated into any somatic cell type, and studied under controlled culture conditions. We review how iPSCs are used to investigate genetic factors and biological mechanisms underlying psychiatric disorders, and considerations for synthesizing data across studies. Recent Findings Results from patient specific-iPSC studies often reveal cellular phenotypes consistent with postmortem and brain imaging studies. Unpredicted findings illustrate the power of iPSCs as a discovery tool, but may also be attributable to limitations in modeling dynamic neural networks or difficulty in identifying the most affected neural subtype or developmental stage. Summary Technological advances in differentiation protocols and organoid generation will enhance our ability to model the salient pathology underlying psychiatric disorders using iPSCs. The field will also benefit from context-driven interpretations of iPSC studies that recognize all potential sources of variability, including differences in patient symptomatology, genetic risk factors, and affected cellular subtype.
      PubDate: 2016-10-14
      DOI: 10.1007/s40473-016-0100-7
       
  • Magnetic Seizure Therapy: an Evolution of Convulsive Therapy
    • Authors: Katalin Martits-Chalangari; Alexis Milton; Mustafa M. Husain
      Abstract: Purpose of Review Treatment-resistant depression (TRD) affects a significant subset of depressed patients. It is estimated that about 30 % of patients with major depressive disorder do not respond to standard treatments. For these patients, electroconvulsive therapy (ECT) remains the most effective treatment despite being limited by its side effects. Modifications to ECT parameters have suggested that it may be possible to separate the therapeutic effects of convulsive therapy from the production of side effects. Recent Findings Magnetic seizure therapy (MST), which uses electromagnetic induction to induce a seizure, is an alternative, experimental convulsive treatment for major depression. Seizures induced by MST are more focal than those produced by ECT, thereby offering greater control over the induced electric field. Most importantly, it offers the potential to provide antidepressant effect without cognitive side effects. Recent findings have further shown the effectiveness of MST and compared cognitive and metabolic side effects to ECT. Summary This article reviews the current literature for clinical studies on MST. While initial results are promising, future work is needed to compare MST efficacy with other antidepressant treatments.
      PubDate: 2016-10-06
      DOI: 10.1007/s40473-016-0094-1
       
  • Psychosis in Alzheimer’s Disease: a Review of Recent Research
           Findings
    • Authors: Corinne E. Fischer; Robert A. Sweet
      Abstract: Purpose of Review The purpose of this review paper is to examine the latest research findings in psychosis in Alzheimer’s disease (AD) and to reconcile conflicting perspectives regarding whether psychotic symptoms should be considered individually (as delusions/hallucinations) or as a whole. Recent Findings AD patients with psychosis demonstrate accelerated onset of cognitive decline prior to the onset of psychosis and are at increased risk of conversion to AD, emphasizing the importance of early detection. Data from neurobiological studies, including imaging and neuropathological studies, suggest there may be merit in breaking down symptoms into delusions and hallucinations while epidemiologic and genetic studies suggest the opposite conclusion. Summary It is conceivable based on the research to date that genetic factors interact with neurodegeneration to create a vulnerability to the development of psychosis in AD. Future studies are required to clarify the specific mechanisms that lead to individual symptoms (delusions/hallucinations).
      PubDate: 2016-10-06
      DOI: 10.1007/s40473-016-0095-0
       
  • Cognitive Remediation and Bias Modification Strategies in Mood and Anxiety
           Disorders
    • Authors: Alexandra K. Gold; Rebecca E. Montana; Louisa G. Sylvia; Andrew A. Nierenberg; Thilo Deckersbach
      Abstract: Purpose of Review Cognitive impairments and biases, which are prevalent in patients with mood and anxiety disorders, can affect quality of life and functioning. Traditional treatments are only insufficiently addressing these impairments and biases. We review the cognitive impairments and biases present in these disorders as well as treatments targeting these domains. Recent Findings Interventions aimed at improving cognitive impairments and biases may help improve cognitive deficits and overall functioning in patients with mood and anxiety disorders. Direct comparisons of treatments for cognitive impairments or biases versus more traditional psychosocial interventions have produced diverse results. Summary Overall, treatments for cognitive impairments and cognitive biases warrant additional study in clinical trials. Future research should explore cognitive remediation and cognitive bias modification adjunctive to psychosocial treatments to optimize patient outcomes in mood and anxiety disorders.
      PubDate: 2016-10-06
      DOI: 10.1007/s40473-016-0090-5
       
  • Type 2 Diabetes, Obesity, and Risk for Dementia: Recent Insights into
           Brain Insulin Resistance and Hypometabolism
    • Abstract: Purpose of Review Type 2 diabetes (T2D) increases risk for the two most common forms of age-related dementia, Alzheimer’s disease (AD), and vascular dementia. This review summarizes key links between T2D and dementia risk and discusses new findings that enhance the understanding of how T2D contributes risk for neurocognitive decline. Recent Findings It is thought that T2D-related insulin resistance may accelerate the accumulation of β-amyloid in the brain. Interestingly, recent studies do not show increased β-amyloid brain pathology in people with T2D. Emerging evidence suggests that brain insulin resistance may be a key feature of AD, but may not correlate with insulin resistance in the body. In addition, new findings about the effects of obesity on brain glucose hypometabolism are reviewed. Summary This review reports on findings suggesting that the contributions of T2D to Alzheimer’s pathology could arise through effects on brain glucose uptake that can occur separately from brain insulin resistance.
      PubDate: 2016-09-28
      DOI: 10.1007/s40473-016-0093-2
       
  • Age-Related Changes in Decision Making
    • Authors: Erika P. Sparrow; Julia Spaniol
      Abstract: Purpose of Review In light of global population trends, the decision-making capacity of older adults is a pressing societal concern. This review focuses on age differences in four key dimensions: valuation, risk taking, temporal discounting, and decision strategies. Recent Findings Aging is associated with structural, functional, and neurochemical changes in neural networks implicated in decision making. However, these changes do not lead to universal deficits. Older adults are not always risk-averse, and their ability to postpone gratification tends to exceed that of younger adults. Age-related changes in motivation influence predecisional information search, valuation of decision outcomes, and selection of decision strategies. Furthermore, age differences are most pronounced when decision tasks tap fluid, rather than crystallized, cognitive abilities. Summary The effects of aging on decision making are heterogeneous and reflect an interplay of cognitive, motivational, and social factors. Seniors’ decisions in health care and finance present critical translational targets for this research.
      PubDate: 2016-09-24
      DOI: 10.1007/s40473-016-0091-4
       
 
 
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