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  Subjects -> BIOLOGY (Total: 3308 journals)
    - BIOCHEMISTRY (255 journals)
    - BIOENGINEERING (129 journals)
    - BIOLOGY (1576 journals)
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    - ZOOLOGY (143 journals)

BIOLOGY (1576 journals)                  1 2 3 4 5 6 7 8 | Last

Showing 1 - 200 of 1720 Journals sorted alphabetically
AAPS Journal     Hybrid Journal   (Followers: 29)
Achievements in the Life Sciences     Open Access   (Followers: 7)
ACS Pharmacology & Translational Science     Hybrid Journal   (Followers: 1)
ACS Synthetic Biology     Hybrid Journal   (Followers: 25)
Acta Biologica Colombiana     Open Access   (Followers: 7)
Acta Biologica Hungarica     Full-text available via subscription   (Followers: 4)
Acta Biologica Sibirica     Open Access   (Followers: 2)
Acta Biologica Turcica     Open Access  
Acta Biologica Venezuelica     Open Access  
Acta Biomaterialia     Hybrid Journal   (Followers: 29)
Acta Biotheoretica     Hybrid Journal   (Followers: 4)
Acta Chiropterologica     Full-text available via subscription   (Followers: 6)
acta ethologica     Hybrid Journal   (Followers: 4)
Acta Fytotechnica et Zootechnica     Open Access   (Followers: 1)
Acta Limnologica Brasiliensia     Open Access   (Followers: 4)
Acta Médica Costarricense     Open Access   (Followers: 2)
Acta Musei Silesiae, Scientiae Naturales     Open Access   (Followers: 1)
Acta Neurobiologiae Experimentalis     Open Access  
Acta Parasitologica     Hybrid Journal   (Followers: 11)
Acta Scientiarum. Biological Sciences     Open Access   (Followers: 2)
Acta Scientifica Naturalis     Open Access   (Followers: 2)
Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis     Open Access   (Followers: 1)
Actualidades Biológicas     Open Access   (Followers: 1)
Advanced Health Care Technologies     Open Access   (Followers: 8)
Advanced Journal of Graduate Research     Open Access  
Advanced Nonlinear Studies     Hybrid Journal  
Advanced Studies in Biology     Open Access  
Advances in Antiviral Drug Design     Full-text available via subscription   (Followers: 2)
Advances in Bioinformatics     Open Access   (Followers: 20)
Advances in Biological Regulation     Hybrid Journal   (Followers: 4)
Advances in Biology     Open Access   (Followers: 12)
Advances in Cell Biology/ Medical Journal of Cell Biology     Open Access   (Followers: 30)
Advances in Cellular and Molecular Biology of Membranes and Organelles     Full-text available via subscription   (Followers: 14)
Advances in Developmental Biology     Full-text available via subscription   (Followers: 13)
Advances in DNA Sequence-Specific Agents     Full-text available via subscription   (Followers: 7)
Advances in Ecological Research     Full-text available via subscription   (Followers: 44)
Advances in Environmental Sciences - International Journal of the Bioflux Society     Open Access   (Followers: 17)
Advances in Enzyme Research     Open Access   (Followers: 11)
Advances in Experimental Biology     Full-text available via subscription   (Followers: 8)
Advances in Genome Biology     Full-text available via subscription   (Followers: 11)
Advances in High Energy Physics     Open Access   (Followers: 22)
Advances in Human Biology     Open Access   (Followers: 4)
Advances in Life Science and Technology     Open Access   (Followers: 18)
Advances in Life Sciences     Open Access   (Followers: 6)
Advances in Marine Biology     Full-text available via subscription   (Followers: 21)
Advances in Molecular and Cell Biology     Full-text available via subscription   (Followers: 25)
Advances in Organ Biology     Full-text available via subscription   (Followers: 2)
Advances in Planar Lipid Bilayers and Liposomes     Full-text available via subscription   (Followers: 3)
Advances in Regenerative Biology     Open Access   (Followers: 2)
Advances in Space Biology and Medicine     Full-text available via subscription   (Followers: 6)
Advances in Structural Biology     Full-text available via subscription   (Followers: 5)
Advances in Tropical Biodiversity and Environmental Sciences     Open Access   (Followers: 1)
Advances in Virus Research     Full-text available via subscription   (Followers: 6)
African Journal of Range & Forage Science     Hybrid Journal   (Followers: 8)
AFRREV STECH : An International Journal of Science and Technology     Open Access   (Followers: 2)
Ageing Research Reviews     Hybrid Journal   (Followers: 12)
Aging Cell     Open Access   (Followers: 25)
Agrokémia és Talajtan     Full-text available via subscription   (Followers: 2)
Agrokreatif Jurnal Ilmiah Pengabdian kepada Masyarakat     Open Access  
AJP Cell Physiology     Hybrid Journal   (Followers: 18)
AJP Endocrinology and Metabolism     Hybrid Journal   (Followers: 24)
AJP Lung Cellular and Molecular Physiology     Hybrid Journal   (Followers: 3)
Al-Kauniyah : Jurnal Biologi     Open Access  
Alasbimn Journal     Open Access   (Followers: 2)
Alces : A Journal Devoted to the Biology and Management of Moose     Open Access  
AMB Express     Open Access   (Followers: 1)
Ambix     Hybrid Journal   (Followers: 3)
American Fern Journal     Full-text available via subscription   (Followers: 1)
American Journal of Agricultural and Biological Sciences     Open Access   (Followers: 9)
American Journal of Bioethics     Hybrid Journal   (Followers: 14)
American Journal of Human Biology     Hybrid Journal   (Followers: 16)
American Journal of Medical and Biological Research     Open Access   (Followers: 10)
American Journal of Plant Sciences     Open Access   (Followers: 20)
American Journal of Primatology     Hybrid Journal   (Followers: 17)
American Malacological Bulletin     Full-text available via subscription   (Followers: 3)
American Naturalist     Full-text available via subscription   (Followers: 80)
Amphibia-Reptilia     Hybrid Journal   (Followers: 6)
Anadol University Journal of Science and Technology B : Theoritical Sciences     Open Access  
Anadolu University Journal of Science and Technology : C Life Sciences and Biotechnology     Open Access   (Followers: 2)
Anaerobe     Hybrid Journal   (Followers: 4)
Analytical Methods     Full-text available via subscription   (Followers: 12)
Anatomical Science International     Hybrid Journal   (Followers: 3)
Animal Cells and Systems     Hybrid Journal   (Followers: 5)
Animal Models and Experimental Medicine     Open Access  
Annales de Limnologie - International Journal of Limnology     Hybrid Journal   (Followers: 1)
Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale     Full-text available via subscription   (Followers: 3)
Annales Henri Poincaré     Hybrid Journal   (Followers: 3)
Annales Universitatis Mariae Curie-Sklodowska, sectio C – Biologia     Open Access   (Followers: 1)
Annals of Applied Biology     Hybrid Journal   (Followers: 7)
Annals of Biomedical Engineering     Hybrid Journal   (Followers: 17)
Annals of Human Biology     Hybrid Journal   (Followers: 5)
Annals of Science and Technology     Open Access  
Annual Review of Biomedical Engineering     Full-text available via subscription   (Followers: 14)
Annual Review of Biophysics     Full-text available via subscription   (Followers: 25)
Annual Review of Cancer Biology     Full-text available via subscription   (Followers: 3)
Annual Review of Cell and Developmental Biology     Full-text available via subscription   (Followers: 39)
Annual Review of Food Science and Technology     Full-text available via subscription   (Followers: 15)
Annual Review of Genomics and Human Genetics     Full-text available via subscription   (Followers: 25)
Annual Review of Phytopathology     Full-text available via subscription   (Followers: 13)
Anthropological Review     Open Access   (Followers: 23)
Antibiotics     Open Access   (Followers: 9)
Antioxidants     Open Access   (Followers: 5)
Antioxidants & Redox Signaling     Hybrid Journal   (Followers: 9)
Antonie van Leeuwenhoek     Hybrid Journal   (Followers: 5)
Anzeiger für Schädlingskunde     Hybrid Journal   (Followers: 1)
Apidologie     Hybrid Journal   (Followers: 4)
Apmis     Hybrid Journal   (Followers: 1)
APOPTOSIS     Hybrid Journal   (Followers: 9)
Applied Biology     Open Access   (Followers: 1)
Applied Bionics and Biomechanics     Open Access   (Followers: 7)
Applied Vegetation Science     Full-text available via subscription   (Followers: 10)
Aquaculture Environment Interactions     Open Access   (Followers: 4)
Aquaculture International     Hybrid Journal   (Followers: 26)
Aquaculture Reports     Open Access   (Followers: 3)
Aquaculture, Aquarium, Conservation & Legislation - International Journal of the Bioflux Society     Open Access   (Followers: 7)
Aquatic Biology     Open Access   (Followers: 6)
Aquatic Ecology     Hybrid Journal   (Followers: 37)
Aquatic Ecosystem Health & Management     Hybrid Journal   (Followers: 15)
Aquatic Science and Technology     Open Access   (Followers: 3)
Aquatic Toxicology     Hybrid Journal   (Followers: 23)
Archaea     Open Access   (Followers: 3)
Archiv für Molluskenkunde: International Journal of Malacology     Full-text available via subscription   (Followers: 3)
Archives of Biological Sciences     Open Access  
Archives of Microbiology     Hybrid Journal   (Followers: 9)
Archives of Natural History     Hybrid Journal   (Followers: 8)
Archives of Oral Biology     Hybrid Journal   (Followers: 3)
Archives of Virology     Hybrid Journal   (Followers: 5)
Archivum Immunologiae et Therapiae Experimentalis     Hybrid Journal   (Followers: 2)
Arid Ecosystems     Hybrid Journal   (Followers: 3)
Arquivos do Instituto Biológico     Open Access   (Followers: 1)
Arquivos do Museu Dinâmico Interdisciplinar     Open Access  
Arthropod Structure & Development     Hybrid Journal   (Followers: 2)
Arthropods     Open Access   (Followers: 1)
Artificial DNA: PNA & XNA     Hybrid Journal   (Followers: 3)
Asian Bioethics Review     Full-text available via subscription   (Followers: 3)
Asian Journal of Biodiversity     Open Access   (Followers: 5)
Asian Journal of Biological Sciences     Open Access   (Followers: 3)
Asian Journal of Cell Biology     Open Access   (Followers: 5)
Asian Journal of Developmental Biology     Open Access   (Followers: 2)
Asian Journal of Medical and Biological Research     Open Access   (Followers: 4)
Asian Journal of Nematology     Open Access   (Followers: 4)
Asian Journal of Poultry Science     Open Access   (Followers: 4)
Atti della Accademia Peloritana dei Pericolanti - Classe di Scienze Medico-Biologiche     Open Access  
Australian Life Scientist     Full-text available via subscription   (Followers: 2)
Australian Mammalogy     Hybrid Journal   (Followers: 7)
Autophagy     Hybrid Journal   (Followers: 4)
Avian Biology Research     Full-text available via subscription   (Followers: 5)
Avian Conservation and Ecology     Open Access   (Followers: 13)
Bacteriology Journal     Open Access   (Followers: 1)
Bacteriophage     Full-text available via subscription   (Followers: 3)
Bangladesh Journal of Bioethics     Open Access  
Bangladesh Journal of Plant Taxonomy     Open Access  
Bangladesh Journal of Scientific Research     Open Access   (Followers: 1)
Batman Üniversitesi Yaşam Bilimleri Dergisi     Open Access  
Berita Biologi     Open Access   (Followers: 1)
Between the Species     Open Access   (Followers: 1)
Bio Tribune Magazine     Hybrid Journal  
BIO Web of Conferences     Open Access  
BIO-Complexity     Open Access  
Bio-Grafía. Escritos sobre la Biología y su enseñanza     Open Access  
Bio-Lectura     Open Access  
Bioanalytical Reviews     Hybrid Journal   (Followers: 2)
Biocatalysis and Biotransformation     Hybrid Journal   (Followers: 6)
BioCentury Innovations     Full-text available via subscription   (Followers: 1)
Biochemistry and Cell Biology     Hybrid Journal   (Followers: 16)
Biochimie     Hybrid Journal   (Followers: 6)
BioControl     Hybrid Journal   (Followers: 6)
Biocontrol Science and Technology     Hybrid Journal   (Followers: 8)
Biodemography and Social Biology     Hybrid Journal  
BioDiscovery     Open Access   (Followers: 2)
Biodiversidade e Conservação Marinha : Revista CEPSUL     Open Access  
Biodiversitas : Journal of Biological Diversity     Open Access  
Biodiversity Data Journal     Open Access   (Followers: 4)
Biodiversity Informatics     Open Access   (Followers: 1)
Biodiversity Information Science and Standards     Open Access   (Followers: 2)
Biodiversity: Research and Conservation     Open Access   (Followers: 26)
Bioedukasi : Jurnal Pendidikan Biologi FKIP UM Metro     Open Access  
Bioeksperimen : Jurnal Penelitian Biologi     Open Access  
Bioelectrochemistry     Hybrid Journal   (Followers: 2)
Bioelectromagnetics     Hybrid Journal   (Followers: 2)
Bioenergy Research     Hybrid Journal   (Followers: 3)
Bioengineering and Bioscience     Open Access   (Followers: 2)
BioEssays     Hybrid Journal   (Followers: 11)
Bioethics     Hybrid Journal   (Followers: 16)
BioéthiqueOnline     Open Access  
Biofabrication     Hybrid Journal   (Followers: 5)
Biofilms     Full-text available via subscription   (Followers: 1)
Biogeosciences (BG)     Open Access   (Followers: 11)
Biogeosciences Discussions (BGD)     Open Access   (Followers: 3)
Bioinformatics     Hybrid Journal   (Followers: 377)
Bioinformatics and Biology Insights     Open Access   (Followers: 12)
Bioinspiration & Biomimetics     Hybrid Journal   (Followers: 7)
Biointerphases     Open Access   (Followers: 1)
Biojournal of Science and Technology     Open Access  
BioLink : Jurnal Biologi Lingkungan, Industri, Kesehatan     Open Access   (Followers: 1)
Biologia     Hybrid Journal  
Biologia on-line : Revista de divulgació de la Facultat de Biologia     Open Access  
Biological Bulletin     Partially Free   (Followers: 6)
Biological Control     Hybrid Journal   (Followers: 8)
Biological Invasions     Hybrid Journal   (Followers: 24)

        1 2 3 4 5 6 7 8 | Last

Similar Journals
Journal Cover
BioDiscovery
Number of Followers: 2  

  This is an Open Access Journal Open Access journal
ISSN (Online) 2050-2966
Published by Pensoft Homepage  [27 journals]
  • Antibacterial activity of thin films TiO2 doped with Ag and Cu on
           Gracilicutes and Firmicutes bacteria

    • Abstract: BioDiscovery 20: e21596
      DOI : 10.3897/biodiscovery.20.e21596
      Authors : Dragomira Stoyanova, Iliana Ivanova, Orlin Angelov, Todorka Vladkova : This article aims to explore the antibacterial activity of thin films of TiO2 doped with Ag and Cu using two types of Gram-negative and Gram-positive test bacteria with clinical significance (Gracilicutes and Firmcutes bacteria). The thin films (thickness of about 60 nm) were deposited on glass substrates by radio frequency magnetron co-sputtering (r.f. power of 50 W) of TiO2 target with Ag and Cu pieces on its surface in an Ar atmosphere (0.8 Pa) without heating during the deposition. The total surface area of the Ag was 60 mm2 and that of the Cu was 100 mm2. Bacillus cereus, Staphylococcus epidermidis, Salmonella enterica, Escherichia coli and Pseudomonas sp. were used as test strains. The antibacterial actvity of the films was evaluated by the classical Koch's method and optical density measurements. The bactericidal effect was established at different time points between 30 min and 90 min for Pseudomonas sp. and S. enterica. The Firmicutes bacteria B. cereus and S. epidermidis were killed at the 4th and 8th hour of the treatment, respectively. The effect on E. coli was bacteriostatic until the 10th hour. The results were confirmed by assessment of the bacterial dehydrogenase activity. The studied thin films of TiO2 co-doped with Ag and Cu have a potential for application as antibacterial coatings. HTML XML PDF
      PubDate: Fri, 15 Dec 2017 15:27:23 +020
       
  • Identification of the gene complexes that determine some individual
           characteristics of a person

    • Abstract: BioDiscovery 20: e21998
      DOI : 10.3897/biodiscovery.20.e21998
      Authors : Irma Mosse, Alexander Kilchevsky, Alexander Gonchar, Maxim Ameliyanovich, Nikita Sedlyar : There are some data about genes associated with certain traits of a person in the scientific literature, but these data are often contradictory. It is evident that complexes of genes that affect the manifestation of the trait can be more informative. We have investigated genotypes of 9000 people, using the PCR method, in order to determine their athletic abilities or predisposition to different diseases and pathologies. In particular, we tested about 3000 women with unknown causes of miscarriages for 14 genes associated with the pregnancy development. 1,5 years later we interviewed 700 women and have identified a high genetic risk of pregnancy loss due to hereditary thrombophilia. In most of the cases, doctors took into account our data and applied for these women treatment with anticoagulant drugs such as fragmin in the subsequent pregnancies. So 86.6% of pregnant women have successfully conceived and given birth, and we have received over 500 touching letters of gratitude. Thus, genetic testing allows to identify individual human properties in order to prevent some pathologies or to chose the most suitable kind of sport. HTML XML PDF
      PubDate: Mon, 6 Nov 2017 15:36:24 +0200
       
  • Innovative sterilization technology - bacterial inactivation by cold argon
           plasma

    • Abstract: BioDiscovery 20: e21977
      DOI : 10.3897/biodiscovery.20.e21977
      Authors : Yovana Todorova, Ivaylo Yotinov, Yana Topalova, Plamena Marinova, Evgenia Benova, Mariana Atanasova, Todor Bogdanov : Non-thermal (cold) plasma is subject of intensive scientific interest as an alternative sterilization technique for advanced control of microbial quality and safety in food biotechnology. The cold plasma is a flow of weakly ionized gas at atmospheric pressure that includes radicals, H2O2, O3, ultraviolet radiation, charged particles, exited metastable atoms, electric fields. One of the major benefits of plasma-based technologies is the synergy between the strong effects of these highly active components that provides a high bactericidal efficiency at low costs, time-saving and non-toxicity. The aim of this study is to assess the bactericidal effect of cold argon plasma in liquids and surfaces, contaminated with Gram-negative and Gram-positive spore-forming bacteria. The used plasma source is surface-wave-sustained discharge (SWD) operating at 2.45 GHz in argon (plasma torch) produced by an electromagnetic wave launcher surfatron type. The bactericidal effect was studied by direct contact treatment of contaminated liquids and agar plates with Pseudomonas aureofaciens AP-9 and Brevibacillus laterosporus BT-271. The results show that the cold argon plasma is able to inactivate bacteria at short exposure time (under 1 min). The clear sterilization zones on treated surfaces with diameter depending on exposure time and initial bacterial density were obtained. In bacteria-contaminated liquids the partial disinfection was observed at least. The potential of plasma based technologies as innovative sterilization approach is high and can be used for various purposes related to microbial control and food safety. HTML XML PDF
      PubDate: Fri, 3 Nov 2017 20:47:28 +0200
       
  • Participation of NO-synthase in Control of Nitric Oxide Level in Rat
           Hippocampus after Modelling of Ischaemic and Haemorrhagic Insult

    • Abstract: BioDiscovery 20: e14810
      DOI : 10.3897/biodiscovery.20.e14810
      Authors : Khalil L. Gainutdinov, Svetlana G. Pashkevich, Vyatcheslav V. Andrianov, Guzel G. Yafarova, Margarita O. Dosina, Tatiana Kh. Bogodvid, Julia P. Stukach, Dinara I. Silant'eva, Aleksandra S. Zamaro , Timur V. Sushko, Vladimir Kulchitsky : Electron paramagnetic resonance (EPR) was used as a method for recording the content of the nitric oxide (NO) in hippocampal tissues of intact rats and rats after modelling of ischaemic and haemorrhagic stroke. Based on direct measurements of NO by EPR spectroscopy, it was shown that, within 5 hours after the onset of symptoms of ischaemic and haemorrhagic stroke, the formation of NO in the hippocampus was reduced by a factor of 2-3 and this reduction was maintained for a period of between 24 and 72 hours. The results show that a systemic character of a decrease in the intensity of NO production during the modelling of ischaemic events in the brain reflects the effects of central dysregulation of the functions at the level of the whole organism such that it is appropriate to consider implementing the correction of the vital systems of the body in a stroke. It has indicated that non-selective NO-synthase blocker L-NAME reduced the low level of NO production by a factor of 3 by its administration within 72 hours after post-ischaemic and haemorrhagic stroke. It was discovered however that L-NAME returns the level of NO production to baseline (control) by its administration within 5 hours after ischaemia. HTML XML PDF
      PubDate: Wed, 18 Oct 2017 12:05:23 +030
       
  • Pilot assessment of cyanotoxins as potential risk factors for cancer in
           Bulgaria

    • Abstract: BioDiscovery 20: e20501
      DOI : 10.3897/biodiscovery.20.e20501
      Authors : Maya Stoyneva-Gärtner, Blagoy Uzunov, Petya Dimitrova : Cyanoprokaryotes (=cyanobacteria, blue-green algae) are the most ancient oxygen-producing phototrophic microorganisms, spread all over the Globe, which form the important basis of different food chains in aquatic and terrestrial habitats. However, due to strong anthropogenic pressure during the last decades they are also responsible for causing nuisance algal blooms in different water bodies with deleterious effects on the mankind and ecosystems mainly due to production of toxic substances (cyanotoxins). Amongst them are the microcystins, nodularins, lyngbyatoxins and aplysiatoxins, known as tumor-promotors with increase of exposure routes through which humans and animals can be placed at risk (Meriluoto et al. 2017). However, the investigations on the relations between the occurrence and development of such diseases with the cyanotoxins and their producers are extremely scarce at a global scale (Yu and Chen 1994, Ueno et al. 1996, Fleming et al. 2002, Svircev et al. 2009, Drobac et al. 2011, Labine et al. 2015). During the last 15 years cyanoblooms and microcystins, nodularins and saxitoxins were detected in 16 different Bulgarian freshwater bodies, including some drinking-water reservoirs (Stoyneva-Gärtner et al. 2017). Amongst the detected toxins some new forms were recognized by their characteristic spectra (Pavlova 2007, Pavlova et al. 2007), and, more recently, a new potential producer of lyngbyatoxin was found in the Black Sea (Stoyneva et al. 2015). The poster shows a pilot assessment of the spread of cancer distribution and mortality vs. spread of cyanoblooms and cyanotoxins in Bulgaria. The pilot assessment is made on the basis of comparison of the general regions of spread of cyanotoxins in Bulgarian water bodies and toxin-producing cyanospecies during the period 2000-2017 (Stoyneva-Gärtner et al. 2017) with the spread of cancer in Bulgaria (e.g. Valerianova et al. 2015). The comparison shows general conformities between the spread of the “most dangerous” water bodies and main regions of cancer diseases in the country. The results obtained served as a basis for a new project proposal which aims at a deepening of the studies for improvement of prevention of cancer in the country. HTML XML PDF
      PubDate: Thu, 24 Aug 2017 15:09:52 +030
       
  • Osteogenic, adipogenic and neurogenic differentiation of human
           adipose-derived mesenchymal stem cells before and after cryopreservation

    • Abstract: BioDiscovery 20: e20272
      DOI : 10.3897/biodiscovery.20.e20272
      Authors : Marina Hristova, Elena Hristova, Plamen Todorov : Mesenchymal stem cells (MSCs) represent a promising tool for the regeneration of damaged tissues in cell therapy. They are characterized as undifferentiated progenitors, which have the ability for self-renewal and multilineage differentiation potential. The development of effective protocols for long-term storage, with the aim of subsequent clinical usage, is essential for their application as cellular therapeutics. In our experiments, we aimed to investigate fresh and cryopreserved human adipose tissue-derived MSCs (AT-MSCs) and their osteogenic, adipogenic and neurogenic differentiation potential. The obtained results pointed out that the cells possess spindle-like shape and form characteristic wave-like layers when reaching confluency. The immunophenotypic analysis shows that they express CD73, CD90 and CD105 and lack the hematopoiеtic lineage markers CD34 and CD45. Both cryopreserved and fresh hAT-MSCs maintain similar ability to specialize towards osteogenic, adipogenic and neural lineage. In conclusion, the present study indicates that the isolated cells are cryotolerant and are able to retain their morphological and immunophenotypical characteristics  after freezing, as well as their multilineage differentiation potential. HTML XML PDF
      PubDate: Mon, 21 Aug 2017 23:16:27 +030
       
  • Two candidate genes for recurrent pregnancy loss and infertility: Could
           ZP3 and UPK3B give us new diagnostic and therapeutic approach'

    • Abstract: BioDiscovery 20: e20113
      DOI : 10.3897/biodiscovery.20.e20113
      Authors : Fatma Sılan, Baris Paksoy, Taner Karakaya, Onur Yildiz, Mine Urfali, Ozturk Ozdemir : Introduction: Chromosomal indels are relatively common cytogenetic abnormalities. Nonetheless, clinical outcomes depend on the location, size and genes in deletion or duplication regions. The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by ZP3(Zona pellucida3) gene is a structural component of the zona pellucida and functions in primary binding and induction of the sperm acrosome reaction. UPK3B(Uroplakin 3B), a minor component of the apical plaques of mammalian urothelium that binds and dimerizes with uroplakin-1b(UPK1B), one of the major conserved urothelium membrane proteins. We herein report two cases presenting with the deletions encompassing POMZP3, UPK3B, ZP3, POM121 and POM121C genes. Case1: 25-year-old female presented to our clinic with recurrent pregnancy loss. After clinical and cytogenetic evaluation, which all of them do not feature, she was diagnosed as the deletion of POMZP3 and UPK3B genes with the array-CGH platform. (Agilent SurePrintG3 HumanCGH 60K) Case2: Ten-week embrio of 34-year-old female, infertile for ten years before and this is her first pregnancy after IVF, revealed the deletion of POM121,POM121C and ZP3 genes with the same array-CGH platform. Conclusion: We have evaluated the deletion of two consecutive genes -UPK3B and ZP3- in the genome by array-CGH analysis. Early abortion or infertility due to triploidic, tetraploidic embryos or uniparental disomy, resulting in a change in the structure of the zona pellucida with the mutations of ZP3 gene, may occur. Also mutations of UPK3B gene may cause abortion or infertility due to endometrial origin with defective function of the urothelium membrane proteins. ICSI could be a good choice for ZP3 deficient infertile woman and if PGS choosen without ICSI, uniparental disomia should be excluded. HTML XML PDF
      PubDate: Thu, 10 Aug 2017 14:04:33 +030
       
  • Comet assay - a sensitive tool for genotoxicity assessment of
           environmental stress in Mytilus galloprovincialis from the Bulgarian Black
           Sea coast

    • Abstract: BioDiscovery 20: e19265
      DOI : 10.3897/biodiscovery.20.e19265
      Authors : Bela Vasileva, Lachezar Yakimov, Borislava Kukurina, Milena Georgieva, George Miloshev, Nesho Chipev : Assessment of DNA damage is of primary concern when the pollution-related stress in living organisms has to be determined. The reason for this concern comes from the evidence that damages in DNA often lead to mutations which are potential threat for the sustainability of organisms and ecological systems. To monitor genotoxicity of the marine environment we have developed a special procedure for application of the method of Comet assay (CA) on the native populations of Mytilus galloprovincialis. Samples were collected from areas with different anthropogenic load along the Bulgarian South Black Sea coast. As the first organ to encounter marine pollutants the gills of the mussels turned-out to be the most appropriate tissue for obtaining a single-cell suspension. Comet assay tests were performed and DNA damage was quantified using several different methods including percentage of DNA in the tail, Comet head and tail area, Comet number, Tail moment, Comet shape, etc. The method allowed us to monitor and predict the genetic risk of marine environmental stressors, particularly persistent pollutants. It proved to be convenient for precise quantification of the on-site loads of genotoxic stress on coastal ecosystems. HTML XML PDF
      PubDate: Tue, 1 Aug 2017 22:58:49 +0300
       
  • Genetic changes in natural Taraxacum officinale populations obtained under
           pollution stress

    • Abstract: BioDiscovery 20: e18712
      DOI : 10.3897/biodiscovery.20.e18712
      Authors : Borislava Kukurina, George Miloshev : Plant populations under stress undergo genotypic alterations which can drive the species towards extinction or adaptation. Defining a suitable plant model and the respective genetic markers for studying the perturbations in the population’s genetic diversity is of crucial importance for the needs of bioconservation and proper ecosystem management. In the current study we prove the usefulness of Taraxacum officinale (common dandelion) as a suitable model plant for genetic biomonitoring. We compared the genotype composition of four specific dandelion populations: 1) a population from the area around the closed “Kremikovtzi” metallurgical plant; 2) a population from the still working “Stomana”-Pernik metallurgical facility; 3) a population from a rural, but naturally rich in heavy metals region close to Bosnek village; 4) a control population from a clean site next to Lokorsko village. Four genetic markers of tree different kinds (a microsatellite, a ribosomal DNA marker and two chloroplastic DNA markers) were tested in order to reveal the genotype diversity in the chosen populations. Our results showed strong quantitative and qualitative genotypic differentiation between pollution-impacted and clean populations. The most interesting observation was that the unique genotypes, considered as result of mutations, were predominantly detected in the plants from the heavy metal polluted regions. HTML XML PDF
      PubDate: Tue, 1 Aug 2017 22:55:33 +0300
       
  • Basal and PGF2α-stimulated secretion of pro-inflammatory cytokines from
           3T3-L1 adipocyte-like cells

    • Abstract: BioDiscovery 20: e17757
      DOI : 10.3897/biodiscovery.20.e17757
      Authors : Bilyana Ilieva, Elena Marinova, Hristo Gagov, Rossitza Konakchieva : Adipocytes were recently identified as an important source of endocrine and paracrine mediators, regulating the metabolism and activity of various cell types and body functions. 3T3-L1 preadipocytes are useful model for physiological, pharmacological and cell signaling studies. Differentiation of 3T3-L1 murine fibroblasts into adipocyte-like cells was conducted in presence of IBMX, dexamethasone and insulin and demonstrated by Oil Red O staining of accumulated lipid droplets. Using Inflammatory Multi- Analyte Cytokines ELISArray Kit we investigated the release of cytokines under basal conditions, after PGF2α treatment for 24 hours to induce pro-inflammatory phenotype, and after PGF2α treatment and incubation in the presence of L-C-Propargylglycine (PGG, 1 mmol/l), a selective inhibitor of cystathionine-gamma-lyase (CSE). The last combination was used to explore the role of H2S, released from CSE, for cytokine and H2O2 release. We found that PGF2α strongly increased TNFα secretion from differentiated adipocytes, the latter effect being antagonized by PGG. The CSE inhibitor enhanced IL-6 production and suppressed IL-10 secretion. PGG enhanced H2O2 production of in PGF2α-treated cells. It is concluded that pro-inflammatory phenotype of differentiated 3T3-L1 adipocyte-like cells, induced by PGF2α is characterized by enhanced TNFα production which critically depends on the ability of CSE to produce H2S.  HTML XML PDF
      PubDate: Tue, 1 Aug 2017 19:14:03 +0300
       
  • Perivascular adipose tissue as regulator of the force of artery
           contractions in health and disease

    • Abstract: BioDiscovery 20: e19831
      DOI : 10.3897/biodiscovery.20.e19831
      Authors : Hristo Gagov, Radoslava Emilova, Daniela Dimitrova, Mitko Mladenov, Rudolf Schubert : During the last two decades, perivascular adipose tissue (PVAT) has been revealed as an important regulator of vascular processes such as proliferation of smooth muscle cells, pro- and anti-oxidant reactions in the vascular wall, angiogenesis, inflammation, apoptosis of neutrophils, migration of monocytes and others. PVAT derived mediators either increase or decrease the amplitudes of the force of artery contraction measured using isometric small vessel myography. In healthy animals and humans predominates the relaxing effect while in diseases the contractile influence of PVAT is common. In aging and pathological conditions like atherosclerosis and diabetes, or with environmental factors like tobacco smoke and high-fat diet, the phenotype of perivascular adipocytes is changed from anti-inflammatory to pro-inflammatory. This change is accompanied by a significant rearrangement of mediators released from PVAT. HTML XML PDF
      PubDate: Tue, 1 Aug 2017 16:21:23 +0300
       
  • Ultrananocrystalline diamond coated implants for enhanced osseointegration

    • Abstract: BioDiscovery 20: e19830
      DOI : 10.3897/biodiscovery.20.e19830
      Authors : Silviya Stateva, Daniel Merker, Cyril Popov, Margarita Apostolova : Osteoporosis causes bones to become weak and brittle. It is known that the alterations in bone metabolism associated to osteoporosis can impair bone healing around implants and affect their osseointegration. The main objective of this study was the development of new nanostructured implant materials based on ultrananocrystalline diamond (UNCD) coatings for enhancing osseointegration. The films were deposited on Ti substrates by microwave plasma CVD from 17% CH4/N2 gas mixtures and modified by O2 or NH3/N2 plasmas. The modifications rendered the H-terminated hydrophobic as-grown films hydrophilic. The interaction of endothelial (EA.hy926) and osteosarcoma (MG63) cells with differently modified UNCD surfaces was investigated by proteome analyses. It revealed the identification of over 19 000 proteins (extracellular and cytosolic). They correspond to 508 (Ti), 634 (UNCD), 651 (O-UNCD), and 668 (NH2-UNCD) protein groups. The interaction network analysis showed differences in the connectivity of inferred protein networks between the ECM niches, which suggests the presence of specific cell microenvironments on O- and NH2-terminated UNCD surfaces. Our results show that due to a favorable combination of surface chemical and topological properties the UNCD films, as-grown and especially after their plasma modifications, may serve as superior scaffolding for promoting the cell attachment and growth during osseointegration. HTML XML PDF
      PubDate: Tue, 1 Aug 2017 15:43:01 +0300
       
  • Testosterone as Diamine Oxidase Activity Regulator

    • Abstract: BioDiscovery 20: e17372
      DOI : 10.3897/biodiscovery.20.e17372
      Authors : Milena Mishonova, Hristo Gagov : Diamine oxidase (DAO) is a key enzyme of the metabolism of polyamines. Its activity was assayed in homogenate of male immature rat liver and kidney.  The androgens are important regulators of polyamines’ metabolism. It was known that testosterone (T) activates DAO in murine kidney, an effect that might depend on the intracellular level of polyamines. The aim of this research was to study the participation of androgen receptor and ornithine decarboxylase (ODC) in DAO testosterone regulation. The rats were treated i.p. 4 hours before measurements with T, T + Hydroxyflutamide (HF), an androgen receptor antagonist or T + difluoromethylornithine (DFMO), an inhibitor of ODC. It was observed that i) T significantly increased DAO activity of rat liver and kidney; ii) the presence of HF abolished the effect of T ; iii) the presence of DFMO slowly reduced the effect of T on DAO activity. It is concluded that T activates DAO mainly by a mechanism, which includes androgen receptor binding and ODC stimulation. HTML XML PDF
      PubDate: Tue, 1 Aug 2017 11:07:33 +0300
       
  • New Mechanisms of Perinatal Hypoxia and Perspectives of
           Pathogenesis-oriented Treatment

    • Abstract: BioDiscovery 20: e14945
      DOI : 10.3897/biodiscovery.20.e14945
      Authors : Larisa A. Balykova, Ludmila V. Ledyajkina, Vladimir A. Trofimov, Alexei P. Vlasov, Irina S. Nazarova, Victor V. Revin : HTML XML PDF
      PubDate: Mon, 17 Jul 2017 23:16:45 +030
       
  • Change in morphometric and oxygen-binding properties of erythrocytes in
           vascular diseases patients

    • Abstract: BioDiscovery 20: e15079
      DOI : 10.3897/biodiscovery.20.e15079
      Authors : Natalia Gromova, Victor Revin, Nadezhda Revina, Anastasiya Kukina, Elvira Revina, Anastasiya Samonova , Ilya Solomadin, Alexander Tychkov, Inessa Moiseeva : HTML XML PDF
      PubDate: Mon, 17 Jul 2017 20:57:38 +030
       
  • Antibacterial activity of thin films TiO2 doped with Ag and Cu on
           Gracilicutes and Firmicutes bacteria

    • Abstract: BioDiscovery 20: e15076
      DOI : 10.3897/biodiscovery.20.e15076
      Authors : Dragomira Stoyanova, Iliana Ivanova, Orlin Angelov, Todorka Vladkova : HTML XML PDF
      PubDate: Mon, 17 Jul 2017 20:24:58 +030
       
  • Application of safe-by-design approach for curing osteoporosis – a
           lock at the future

    • Abstract: BioDiscovery 20: e15099
      DOI : 10.3897/biodiscovery.20.e15099
      Authors : Armine Grigoryan, Iliyan Kolev, Anelia Dimitrova, Margarita Apostolova : HTML XML PDF
      PubDate: Mon, 17 Jul 2017 20:00:32 +030
       
  • Antiviral activity of Stachys Thracica Dav. extracts against Human Herpes
           virus type 1 and 2

    • Abstract: BioDiscovery 20: e15022
      DOI : 10.3897/biodiscovery.20.e15022
      Authors : Petya Angelova, Venelin Tsvetkov, Anton Hinkov, Daniel Todorov, Kalina Shishkova, Zhenya Yordanova, Veneta Kapchina-Toteva, Stoyan Shishkov : HTML XML PDF
      PubDate: Mon, 17 Jul 2017 16:38:18 +030
       
  • Synthesis of a drug discovery library for the identification of sigma
           receptors modulators

    • Abstract: BioDiscovery 20: e14958
      DOI : 10.3897/biodiscovery.20.e14958
      Authors : Giacomo Rossino, Marta Rui, Marcello Di Giacomo, Daniela Rossi, Simona Collina : HTML XML PDF
      PubDate: Mon, 17 Jul 2017 13:24:10 +030
       
  • Recent advances in the structure-guided research and development of
           antimicrobial therapeutics

    • Abstract: BioDiscovery 20: e14952
      DOI : 10.3897/biodiscovery.20.e14952
      Authors : Dimitar Trifonov, Tom Evers : HTML XML PDF
      PubDate: Mon, 17 Jul 2017 10:24:41 +030
       
  • Validation of a novel HPLC-based serum thymidine kinase assay for breast
           cancer detection

    • Abstract: BioDiscovery 20: e14563
      DOI : 10.3897/biodiscovery.20.e14563
      Authors : Elena Kuzmanova, Marilena Spanou, Emma Leckie, Nikolai Zhelev : HTML XML PDF
      PubDate: Wed, 5 Jul 2017 5:44:23 +0300
       
  • A step forward in the identification of compounds interfering with the
           Embryonic Lethal Abnormal Vision (ELAV) protein - RNA complexes

    • Abstract: BioDiscovery 20: e14670
      DOI : 10.3897/biodiscovery.20.e14670
      Authors : Serena Della Volpe, Daniela Rossi, Francesca Vasile, Donatella Potenza, Marialaura Amadio, Alessia Pascale, Simona Collina : HTML XML PDF
      PubDate: Wed, 5 Jul 2017 4:44:08 +0300
       
  • Sigma 1 receptor modulators as a new weapon against multiple sclerosis

    • Abstract: BioDiscovery 20: e14565
      DOI : 10.3897/biodiscovery.20.e14565
      Authors : Simona Collina, Marta Rui, Giacomo Rossino, Serena Della Volpe, Daniela Rossi, Arianna Scuteri, Alessio Malacrida, Guido Cavaletti : HTML XML PDF
      PubDate: Wed, 5 Jul 2017 3:40:56 +0300
       
  • Cryogenic pretreatment of keratinous waste for enhanced methane production

    • Abstract: BioDiscovery 20: e14096
      DOI : 10.3897/biodiscovery.20.e14096
      Authors : Elena Kuzmanova, Joseph Akunna, Nikolai Zhelev : HTML XML PDF
      PubDate: Wed, 5 Jul 2017 2:40:27 +0300
       
  • The effects of changes in composition and state of the lipids on
           erythrocytes’ oxygen-transport function in pathological conditions
           associated with the development of hypoxia

    • Abstract: BioDiscovery 20: e14701
      DOI : 10.3897/biodiscovery.20.e14701
      Authors : Victor V. Revin, Natalia V. Gromova, Elvira S. Revina, Ilya N. Solomadin, Alexander Yu. Tychkov : HTML XML PDF
      PubDate: Wed, 5 Jul 2017 1:39:59 +0300
       
  • Phosphorylase Kinase Inhibition Therapy in Burns and Scalds

    • Abstract: BioDiscovery 20: e11207
      DOI : 10.3897/biodiscovery.20.e11207
      Authors : Madalene Heng : Severe burns and scalds almost always result in unsightly hypertrophic scarring. Among the important processes involved in scarring are fibroblast formation and transformation of fibroblasts into myofibroblasts. Myofibroblasts contain α-smooth muscle actin which has contractile properties and can lead to wound contraction and hypertrophic scarring. Phosphorylase kinase (PhK), expressed within 5 mins of injury, is among the earliest enzymes released after tissue damage. It is responsible for activation of NF-kB, which in turn activates over 200 different genes related to inflammation, fibroblastic proliferation, myofibroblast conversion, and eventual scar tissue formation. The sequence and approximate timing of events following injury include the following: activation of PhK (5 mins), followed by appearance of neutrophils (30 mins), macrophages (hours to days), fibroblasts (1 week) and myofibroblasts (2 weeks). Cytokines and growth factors secreted by macrophages include fibroblast growth factor (FGF) and transforming growth factors α and β (TGFα and TGFβ). Fibroblast growth factor is responsible for fibroblastic proliferation, and TGFβ1 for conversion of fibroblasts into myofibroblasts. After thermal injury, the use of topical curcumin, a non-competitive, selective PhK inhibitor that blocks PhK activity upstream of NF-kB activation, was found to be associated with more rapid and improved skin healing, as well as less severe or absent scarring. HTML XML PDF
      PubDate: Fri, 24 Feb 2017 10:49:14 +020
       
  • Drug resistance of cancer cells is crucially affected by expression levels
           of ABC-transporters

    • Abstract: BioDiscovery 20: e11211
      DOI : 10.3897/biodiscovery.20.e11211
      Authors : Petr Mlejnek, Petr Dolezel, Eliska Ruzickova : Dasatinib (DAS), a second generation of tyrosine kinase inhibitor (TKI), represents excellent choice for the treatment of chronic myeloid leukemia resistant to imatinib. Unfortunately, recent laboratory studies suggested that antiproliferative effect of DAS might be significantly reduced due to the overexpression of the ATP-binding cassette (ABC) transporters, ABCB1 and ABCG2. However, whether these drug transporters might compromise therapeutic effect of DAS in clinic is unclear. We believe that the drug transporter expression level is a crucial factor that affects the results and its consideration may help to explain the existing controversy. In addition, clinically relevant concentrations of drug must be used. In our study, human leukemia K562 cells with high and low expression levels of ABCB1 or ABCG2 were used. DAS was applied at nanomolar concentrations. We observed that K562 cells expressing high levels of ABCB1 and ABCG2 contained significantly reduced intracellular levels of DAS and these cells exhibited significantly increased resistance to this drug. Importantly, cells with the low expression of ABCB1 or ABCG2 effluxed DAS less efficiently, however, still significantly. Accordingly, the observed resistance was lower but significant. Conclusions: The antiproliferative effects of DAS might be reduced by ABCB1 or ABCG2. However, the actual effect of these ABC transporters on DAS efficiency depends on their expression levels. The lower expression levels of ABC transporters mediate lower resistance. Considering the fact that expression levels of ABCB1 and ABCG2 transporters are usually low in clinical samples, their contribution to the overall resistance to DAS is probably low but significant. HTML XML PDF
      PubDate: Wed, 8 Feb 2017 10:52:09 +0200
       
  • Screening an Archetypal Collection of Microorganisms for the Presence of
           Unexplored Antimicrobial Compounds

    • Abstract: BioDiscovery 20: e10763
      DOI : 10.3897/biodiscovery.20.e10763
      Authors : Lucia Cimarelli, Anna Maria Giuliodori, Anna Brandi, Karolina Adamkiewicz, Roberto Spurio, Attilio Fabbretti : HTML XML PDF
      PubDate: Wed, 8 Feb 2017 9:26:49 +0200
       
  • The success of stem cell transplantations and the potential
           post-transplantation complications may be dependent, among other factors,
           on the capacity of the recipient and the transplanted cells to repair DNA
           damage

    • Abstract: BioDiscovery 19: e9076
      DOI : 10.3897/BioDiscovery.19.e9076
      Authors : Lewis Reynolds : Cell therapy is presently a treatment of choice for many types of haematological and metabolic diseases and is likely to become a therapeutic option for other severe human diseases and conditions in the near future. The success of cell transplantation depends on a variety of factors, including the degree of HLA match between the donor and the recipient, the infectious burden of the graft, cell dosage, age, general state of the recipient and other incompletely characterised features of the donor and the recipient. It is likely that the individual capacity for identification and repair of DNA damage and maintenance of genomic integrity may account, at least in part, for these elusive factors that modulate transplantation outcome in terms of success rate and both long and short term post-transplantation complications. This paper outlines the role of individual repair capacity of the donor and recipient in cell transplantations, summarising the little knowledge already accumulated in the field whilst analysing the known major issues of the use of different types of stem cells. Attention will be given to their capacity to maintain the integrity of their genome, the ability to renew their own population, differentiate into various cell types and in some cases, succumb to carcinogenic transformation. Analysis of the individual capacity may become a useful tool in the assessment of the suitability of a set of freshly collected stem cells or an in vitro propagated cell line for potential clinical applications. HTML XML PDF
      PubDate: Tue, 29 Mar 2016 15:59:32 +030
       
 
 
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