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  Subjects -> BIOLOGY (Total: 2996 journals)
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BIOLOGY (1424 journals)                  1 2 3 4 5 6 7 8 | Last

Showing 1 - 200 of 1720 Journals sorted alphabetically
AAPS Journal     Hybrid Journal   (Followers: 20)
Achievements in the Life Sciences     Open Access   (Followers: 4)
ACS Synthetic Biology     Full-text available via subscription   (Followers: 21)
Acta Biologica Colombiana     Open Access   (Followers: 7)
Acta Biologica Hungarica     Full-text available via subscription   (Followers: 4)
Acta Biologica Sibirica     Open Access  
Acta Biomaterialia     Hybrid Journal   (Followers: 25)
Acta Biotheoretica     Hybrid Journal   (Followers: 5)
Acta Chiropterologica     Full-text available via subscription   (Followers: 6)
acta ethologica     Hybrid Journal   (Followers: 4)
Acta Limnologica Brasiliensia     Open Access   (Followers: 3)
Acta Médica Costarricense     Open Access   (Followers: 2)
Acta Musei Silesiae, Scientiae Naturales : The Journal of Silesian Museum in Opava     Open Access  
Acta Neurobiologiae Experimentalis     Open Access  
Acta Parasitologica     Hybrid Journal   (Followers: 9)
Acta Scientiarum. Biological Sciences     Open Access   (Followers: 2)
Acta Scientifica Naturalis     Open Access   (Followers: 2)
Actualidades Biológicas     Open Access   (Followers: 1)
Advanced Health Care Technologies     Open Access   (Followers: 4)
Advances in Antiviral Drug Design     Full-text available via subscription   (Followers: 3)
Advances in Bioinformatics     Open Access   (Followers: 18)
Advances in Biological Regulation     Hybrid Journal   (Followers: 4)
Advances in Biosensors and Bioelectronics     Open Access   (Followers: 6)
Advances in Cell Biology     Open Access   (Followers: 24)
Advances in Cellular and Molecular Biology of Membranes and Organelles     Full-text available via subscription   (Followers: 12)
Advances in Developmental Biology     Full-text available via subscription   (Followers: 11)
Advances in DNA Sequence-Specific Agents     Full-text available via subscription   (Followers: 5)
Advances in Ecological Research     Full-text available via subscription   (Followers: 41)
Advances in Environmental Sciences - International Journal of the Bioflux Society     Open Access   (Followers: 20)
Advances in Enzyme Research     Open Access   (Followers: 9)
Advances in Experimental Biology     Full-text available via subscription   (Followers: 7)
Advances in Genome Biology     Full-text available via subscription   (Followers: 11)
Advances in High Energy Physics     Open Access   (Followers: 19)
Advances in Human Biology     Open Access   (Followers: 1)
Advances in Life Science and Technology     Open Access   (Followers: 14)
Advances in Life Sciences     Open Access   (Followers: 4)
Advances in Marine Biology     Full-text available via subscription   (Followers: 15)
Advances in Molecular and Cell Biology     Full-text available via subscription   (Followers: 22)
Advances in Planar Lipid Bilayers and Liposomes     Full-text available via subscription   (Followers: 3)
Advances in Regenerative Biology     Open Access   (Followers: 1)
Advances in Structural Biology     Full-text available via subscription   (Followers: 8)
Advances in Virus Research     Full-text available via subscription   (Followers: 5)
African Journal of Range & Forage Science     Hybrid Journal   (Followers: 6)
AFRREV STECH : An International Journal of Science and Technology     Open Access   (Followers: 1)
Ageing Research Reviews     Hybrid Journal   (Followers: 8)
Aging Cell     Open Access   (Followers: 10)
Agrokémia és Talajtan     Full-text available via subscription   (Followers: 2)
Agrokreatif Jurnal Ilmiah Pengabdian kepada Masyarakat     Open Access  
AJP Cell Physiology     Full-text available via subscription   (Followers: 13)
AJP Endocrinology and Metabolism     Full-text available via subscription   (Followers: 22)
AJP Lung Cellular and Molecular Physiology     Full-text available via subscription   (Followers: 3)
Al-Kauniyah : Jurnal Biologi     Open Access  
Alasbimn Journal     Open Access   (Followers: 1)
AMB Express     Open Access   (Followers: 1)
Ambix     Hybrid Journal   (Followers: 3)
American Biology Teacher     Full-text available via subscription   (Followers: 13)
American Fern Journal     Full-text available via subscription   (Followers: 1)
American Journal of Agricultural and Biological Sciences     Open Access   (Followers: 10)
American Journal of Bioethics     Hybrid Journal   (Followers: 10)
American Journal of Biostatistics     Open Access   (Followers: 9)
American Journal of Human Biology     Hybrid Journal   (Followers: 12)
American Journal of Medical and Biological Research     Open Access   (Followers: 5)
American Journal of Plant Sciences     Open Access   (Followers: 19)
American Journal of Primatology     Hybrid Journal   (Followers: 15)
American Malacological Bulletin     Full-text available via subscription   (Followers: 3)
American Naturalist     Full-text available via subscription   (Followers: 67)
Amphibia-Reptilia     Hybrid Journal   (Followers: 6)
Anaerobe     Hybrid Journal   (Followers: 4)
Analytical Methods     Full-text available via subscription   (Followers: 9)
Anatomical Science International     Hybrid Journal   (Followers: 2)
Animal Cells and Systems     Hybrid Journal   (Followers: 4)
Annales de Limnologie - International Journal of Limnology     Hybrid Journal   (Followers: 1)
Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale     Full-text available via subscription   (Followers: 3)
Annales Henri Poincaré     Hybrid Journal   (Followers: 3)
Annales UMCS, Biologia     Open Access   (Followers: 1)
Annals of Applied Biology     Hybrid Journal   (Followers: 7)
Annals of Biomedical Engineering     Hybrid Journal   (Followers: 18)
Annals of Human Biology     Hybrid Journal   (Followers: 4)
Annual Review of Biomedical Engineering     Full-text available via subscription   (Followers: 17)
Annual Review of Biophysics     Full-text available via subscription   (Followers: 25)
Annual Review of Cancer Biology     Full-text available via subscription   (Followers: 1)
Annual Review of Cell and Developmental Biology     Full-text available via subscription   (Followers: 39)
Annual Review of Food Science and Technology     Full-text available via subscription   (Followers: 15)
Annual Review of Genomics and Human Genetics     Full-text available via subscription   (Followers: 19)
Annual Review of Phytopathology     Full-text available via subscription   (Followers: 10)
Anthropological Review     Open Access   (Followers: 25)
Anti-Infective Agents     Hybrid Journal   (Followers: 3)
Antibiotics     Open Access   (Followers: 9)
Antioxidants     Open Access   (Followers: 4)
Antioxidants & Redox Signaling     Hybrid Journal   (Followers: 8)
Antonie van Leeuwenhoek     Hybrid Journal   (Followers: 5)
Anzeiger für Schädlingskunde     Hybrid Journal   (Followers: 1)
Apidologie     Hybrid Journal   (Followers: 4)
Apmis     Hybrid Journal   (Followers: 1)
APOPTOSIS     Hybrid Journal   (Followers: 8)
Applied Bionics and Biomechanics     Open Access   (Followers: 8)
Applied Vegetation Science     Full-text available via subscription   (Followers: 9)
Aquaculture Environment Interactions     Open Access   (Followers: 2)
Aquaculture International     Hybrid Journal   (Followers: 22)
Aquaculture Reports     Open Access   (Followers: 3)
Aquaculture, Aquarium, Conservation & Legislation - International Journal of the Bioflux Society     Open Access   (Followers: 6)
Aquatic Biology     Open Access   (Followers: 5)
Aquatic Ecology     Hybrid Journal   (Followers: 30)
Aquatic Ecosystem Health & Management     Hybrid Journal   (Followers: 13)
Aquatic Science and Technology     Open Access   (Followers: 3)
Aquatic Toxicology     Hybrid Journal   (Followers: 18)
Archaea     Open Access   (Followers: 3)
Archiv für Molluskenkunde: International Journal of Malacology     Full-text available via subscription   (Followers: 3)
Archives of Biomedical Sciences     Open Access   (Followers: 7)
Archives of Microbiology     Hybrid Journal   (Followers: 8)
Archives of Natural History     Hybrid Journal   (Followers: 7)
Archives of Oral Biology     Hybrid Journal   (Followers: 2)
Archives of Virology     Hybrid Journal   (Followers: 5)
Archivum Immunologiae et Therapiae Experimentalis     Hybrid Journal   (Followers: 2)
Arid Ecosystems     Hybrid Journal   (Followers: 3)
Arquivos do Instituto Biológico     Open Access   (Followers: 1)
Arquivos do Museu Dinâmico Interdisciplinar     Open Access  
Arthropod Structure & Development     Hybrid Journal   (Followers: 2)
Arthropods     Open Access   (Followers: 1)
Artificial DNA: PNA & XNA     Hybrid Journal   (Followers: 2)
Artificial Photosynthesis     Open Access   (Followers: 1)
Asian Bioethics Review     Full-text available via subscription   (Followers: 1)
Asian Journal of Biodiversity     Open Access   (Followers: 5)
Asian Journal of Biological Sciences     Open Access   (Followers: 3)
Asian Journal of Cell Biology     Open Access   (Followers: 6)
Asian Journal of Developmental Biology     Open Access   (Followers: 2)
Asian Journal of Medical and Biological Research     Open Access   (Followers: 2)
Asian Journal of Nematology     Open Access   (Followers: 3)
Asian Journal of Poultry Science     Open Access   (Followers: 4)
Australian Life Scientist     Full-text available via subscription   (Followers: 2)
Australian Mammalogy     Hybrid Journal   (Followers: 6)
Autophagy     Hybrid Journal   (Followers: 2)
Avian Biology Research     Full-text available via subscription   (Followers: 4)
Avian Conservation and Ecology     Open Access   (Followers: 12)
Bacteriology Journal     Open Access   (Followers: 2)
Bacteriophage     Full-text available via subscription   (Followers: 3)
Bangladesh Journal of Bioethics     Open Access  
Bangladesh Journal of Plant Taxonomy     Open Access  
Bangladesh Journal of Scientific Research     Open Access   (Followers: 1)
Berita Biologi     Open Access   (Followers: 1)
Between the Species     Open Access   (Followers: 1)
Bio Tribune Magazine     Hybrid Journal  
BIO Web of Conferences     Open Access  
BIO-Complexity     Open Access  
Bio-Grafía. Escritos sobre la Biología y su enseñanza     Open Access  
Bioanalytical Reviews     Hybrid Journal   (Followers: 2)
Biocatalysis and Biotransformation     Hybrid Journal   (Followers: 6)
Biochemistry and Cell Biology     Hybrid Journal   (Followers: 14)
Biochimie     Hybrid Journal   (Followers: 7)
BioControl     Hybrid Journal   (Followers: 5)
Biocontrol Science and Technology     Hybrid Journal   (Followers: 5)
Biodemography and Social Biology     Hybrid Journal   (Followers: 1)
Biodiversidad Colombia     Open Access  
Biodiversity : Research and Conservation     Open Access   (Followers: 26)
Biodiversity and Natural History     Open Access   (Followers: 5)
Biodiversity Data Journal     Open Access   (Followers: 3)
Biodiversity Informatics     Open Access  
Bioedukasi : Jurnal Pendidikan Biologi FKIP UM Metro     Open Access  
Bioeksperimen : Jurnal Penelitian Biologi     Open Access  
Bioelectrochemistry     Hybrid Journal   (Followers: 2)
Bioelectromagnetics     Hybrid Journal   (Followers: 1)
Bioenergy Research     Hybrid Journal   (Followers: 2)
Bioengineering and Bioscience     Open Access   (Followers: 1)
BioEssays     Hybrid Journal   (Followers: 10)
Bioethics     Hybrid Journal   (Followers: 14)
BioéthiqueOnline     Open Access  
Biofabrication     Hybrid Journal   (Followers: 3)
Biogeosciences (BG)     Open Access   (Followers: 10)
Biogeosciences Discussions (BGD)     Open Access   (Followers: 1)
Bioinformatics     Hybrid Journal   (Followers: 305)
Bioinformatics and Biology Insights     Open Access   (Followers: 15)
Bioinspiration & Biomimetics     Hybrid Journal   (Followers: 6)
Biointerphases     Open Access   (Followers: 1)
Biojournal of Science and Technology     Open Access  
Biologia     Hybrid Journal  
Biologia on-line : Revista de divulgació de la Facultat de Biologia     Open Access  
Biological Bulletin     Partially Free   (Followers: 4)
Biological Control     Hybrid Journal   (Followers: 5)
Biological Invasions     Hybrid Journal   (Followers: 16)
Biological Journal of the Linnean Society     Hybrid Journal   (Followers: 16)
Biological Letters     Open Access   (Followers: 4)
Biological Procedures Online     Open Access  
Biological Psychiatry     Hybrid Journal   (Followers: 43)
Biological Psychology     Hybrid Journal   (Followers: 6)
Biological Research     Open Access  
Biological Rhythm Research     Hybrid Journal   (Followers: 2)
Biological Theory     Hybrid Journal   (Followers: 1)
Biological Trace Element Research     Hybrid Journal  
Biologicals     Full-text available via subscription   (Followers: 9)
Biologics: Targets & Therapy     Open Access   (Followers: 1)
Biologie Aujourd'hui     Full-text available via subscription  
Biologie in Unserer Zeit (Biuz)     Hybrid Journal   (Followers: 42)
Biologija     Open Access  
Biology     Open Access   (Followers: 5)
Biology and Philosophy     Hybrid Journal   (Followers: 16)
Biology Bulletin     Hybrid Journal   (Followers: 1)
Biology Bulletin Reviews     Hybrid Journal  
Biology Direct     Open Access   (Followers: 7)
Biology Letters     Full-text available via subscription   (Followers: 36)
Biology Methods and Protocols     Hybrid Journal  

        1 2 3 4 5 6 7 8 | Last

Journal Cover Advances in Molecular and Cell Biology
  [22 followers]  Follow
    
   Full-text available via subscription Subscription journal
   ISSN (Print) 1569-2558
   Published by Elsevier Homepage  [3044 journals]
  • Chloride‐Transporting Proteins in Mammalian Organisms: An Overview
    • Abstract: 2006
      Publication year: 2006
      Source:Advances in Molecular and Cell Biology, Volume 38



      PubDate: 2012-12-17T07:19:13Z
       
  • Physiological Functions of the CLC Chloride Transport Proteins
    • Abstract: 2006
      Publication year: 2006
      Source:Advances in Molecular and Cell Biology, Volume 38



      PubDate: 2012-12-17T07:19:13Z
       
  • Structure and Function of CLC Chloride Channels and Transporters
    • Abstract: 2006
      Publication year: 2006
      Source:Advances in Molecular and Cell Biology, Volume 38



      PubDate: 2012-12-17T07:19:13Z
       
  • Pharmacology of CLC Chloride Channels and Transporters
    • Abstract: 2006
      Publication year: 2006
      Source:Advances in Molecular and Cell Biology, Volume 38



      PubDate: 2012-12-17T07:19:13Z
       
  • The Physiology and Pharmacology of the CFTR Cl− Channel
    • Abstract: 2006
      Publication year: 2006
      Source:Advances in Molecular and Cell Biology, Volume 38



      PubDate: 2012-12-17T07:19:13Z
       
  • Gating of Cystic Fibrosis Transmembrane Conductance Regulator Chloride
           Channel
    • Abstract: 2006
      Publication year: 2006
      Source:Advances in Molecular and Cell Biology, Volume 38



      PubDate: 2012-12-17T07:19:13Z
       
  • Functional Properties of Ca2+‐Dependent Cl− Channels and Bestrophins:
           Do They Correlate'
    • Abstract: 2006
      Publication year: 2006
      Source:Advances in Molecular and Cell Biology, Volume 38



      PubDate: 2012-12-17T07:19:13Z
       
  • Cell Volume Homeostasis: The Role of Volume‐Sensitive Chloride
           Channels
    • Abstract: 2006
      Publication year: 2006
      Source:Advances in Molecular and Cell Biology, Volume 38



      PubDate: 2012-12-17T07:19:13Z
       
  • GABAergic Synaptic Transmission
    • Abstract: 2006
      Publication year: 2006
      Source:Advances in Molecular and Cell Biology, Volume 38



      PubDate: 2012-12-17T07:19:13Z
       
  • Physiology of Cation‐Chloride Cotransporters
    • Abstract: 2006
      Publication year: 2006
      Source:Advances in Molecular and Cell Biology, Volume 38



      PubDate: 2012-12-17T07:19:13Z
       
  • Plasma Membrane Cl−/HCO3− Exchange Proteins
    • Abstract: 2006
      Publication year: 2006
      Source:Advances in Molecular and Cell Biology, Volume 38



      PubDate: 2012-12-17T07:19:13Z
       
  • Orchestration of Vectorial Chloride Transport by Epithelia
    • Abstract: 2006
      Publication year: 2006
      Source:Advances in Molecular and Cell Biology, Volume 38



      PubDate: 2012-12-17T07:19:13Z
       
  • Contributors to Volume 38
    • Abstract: 2006
      Publication year: 2006
      Source:Advances in Molecular and Cell Biology, Volume 38



      PubDate: 2012-12-17T07:19:13Z
       
  • The Cytoskeleton of the Platelet
    • Abstract: 2006
      Publication year: 2006
      Source:Advances in Molecular and Cell Biology, Volume 37

      Platelets contain a membrane cytoskeleton, a cytoplasmic core cytoskeleton, and a microtubule system that are closely connected and act in concert to maintain the resting platelet discoid shape. A system of intracellular activatory and inhibitory signaling molecules interacts directly or indirectly with these cytoskeletal structures and tightly controls the cytoskeletal function. During platelet adhesion, activation, and aggregation, these cytoskeletal structures are rearranged resulting in the formation of a variety of F‐actin‐based structures, including filopodia and lamellipodia. Cytoskeletal remodeling is initiated by membrane receptors and signaling proteins that are in close contact with the platelet cytoskeleton. In turn, the cytoskeleton serves as a scaffold that binds and localizes signaling molecules at the right place and the right time to warrant platelet hemostatic function.

      PubDate: 2012-12-17T07:19:13Z
       
  • The Actin Cytoskeleton in the Apical Domain of Epithelial Cells
    • Abstract: 2006
      Publication year: 2006
      Source:Advances in Molecular and Cell Biology, Volume 37



      PubDate: 2012-12-17T07:19:13Z
       
  • The Connection Between Actin ATPase and Polymerization
    • Abstract: 2006
      Publication year: 2006
      Source:Advances in Molecular and Cell Biology, Volume 37

      Remodeling of the actin filament system in cells results from strictly regulated polymerization and depolymerization of actin, where hydrolysis of actin‐bound ATP is crucial. Actin–actin interactions are influenced by the state of the bound nucleotide, and many microfilament regulators influence the actin ATPase by binding preferentially either to ATP/ADP·Pi‐ or ADP‐bound actin. This chapter summarizes observations made concerning the actin ATPase and its role in the biological activity of actin and actin filaments.

      PubDate: 2012-12-17T07:19:13Z
       
  • Spectrin Function: A Survey of Genetic Systems from Drosophila to Humans
    • Abstract: 2006
      Publication year: 2006
      Source:Advances in Molecular and Cell Biology, Volume 37

      Spectrin and ankyrin are major components of a plasma membrane‐associated scaffold known as the spectrin cytoskeleton. Spectrin is thought to cross‐link actin filaments in a two‐dimensional submembrane network and ankyrin links the network to a number of integral membrane activities, including the sodium pump, voltage‐dependent sodium channels, and L1‐family cell adhesion molecules. Genetic studies have established that the spectrin cytoskeleton is required for the normal accumulation of these integral proteins at their normal sites of function. Defects in spectrin and ankyrin have been implicated in human disease, and studies in model genetic organisms are making it possible to elucidate the mechanisms behind their effects. Cell culture studies have also shed new light on the processes that govern formation of polarized membrane domains. This chapter surveys the results and their implications for the assembly and function of the spectrin cytoskeleton.

      PubDate: 2012-12-17T07:19:13Z
       
  • Structure and Function of Villin
    • Abstract: 2006
      Publication year: 2006
      Source:Advances in Molecular and Cell Biology, Volume 37

      Villin is an epithelial cell‐specific protein that belongs to a family of actin‐binding proteins that display structural and functional homology and include among other proteins, gelsolin, severin, fragmin, adseverin/scinderin, supervillin, and protovillin. Villin is unique among these proteins in that it can sever, cap, nucleate, and crosslink actin filaments. The actin modifying functions of villin are regulated by calcium, phosphoinositides, and tyrosine phosphorylation of the villin protein. Villin also self‐associates and this property of villin is likewise determined by its ligand‐binding properties. Overexpression of villin regulates actin redistribution, cell morphology, cell migration, and cell death. Studies done with the villin knockout mice substantiate the significance of villin in actin reorganization and maintenance of epithelial cell plasticity. In this chapter I discuss how the ligand‐binding properties of villin are mechanistically important to its functions in cell migration and cell death.

      PubDate: 2012-12-17T07:19:13Z
       
  • Roles of the Actin Cytoskeleton and Myosins in the Endomembrane System
    • Abstract: 2006
      Publication year: 2006
      Source:Advances in Molecular and Cell Biology, Volume 37

      The positioning of the endomembrane system (biosynthetic/secretory and endocytic pathways) and the constant movement of constituents between these compartments requires the involvement of the cytoskeleton and cytoskeletal‐based motors. Whereas much is known about the roles of the microtubule (MT) cytoskeleton in these events, considerably less is known about the roles of the actin cytoskeleton. Recent work has shown that the Golgi complex is linked to an actin‐based network that is important for Golgi morphology and the trafficking of Golgi‐derived membranes. Moreover, many of the cellular players used to transport cargo near the actin‐rich network subjacent to the plasma membrane (PM) may function near the Golgi.

      PubDate: 2012-12-17T07:19:13Z
       
  • The BRG1 and the Actin Filament System
    • Abstract: 2006
      Publication year: 2006
      Source:Advances in Molecular and Cell Biology, Volume 37

      The DNA in eukaryotic cells is organized with proteins into chromatin. The chromatin structure is dynamic, altered when factors that use DNA as a template need access or to silence regions of the chromosome. The alteration of the chromatin structure is primarily the responsibility of ATP‐dependent chromatin‐remodeling complexes and histone‐modifying complexes. ATP‐dependent chromatin‐remodeling factors of the SWI/SNF family affect the actin filament orgainzation in the cytoplasm. The SWI/SNF family of chromatin‐remodeling complexes is required in transcription of many genes, and the effect on the actin filament organization depends on cell type context, in particular, the various signaling pathways activated in each cell type. In many cell types, SWI/SNF complexes affect the protein level of adhesion molecules and Rho pathway effector molecules. Actin, together with actin‐related proteins (ARPs) are also present in the nucleus and are implicated in mRNA export, transcription, DNA repair, and chromatin remodeling. Actin associate to all three types of eukaryotic RNA polymerases (pol). In addition, actin and ARPs are part of several chromatin‐remodeling complexes purified from yeast, Drosophila, and mammalian cells. The function of actin and ARPs in the nucleus is still unclear, and it is proposed that they work as motor proteins or as structural proteins in different complexes.

      PubDate: 2012-12-17T07:19:13Z
       
  • Ionic Waves Propagation Along the Dendritic Cytoskeleton as a Signaling
           Mechanism
    • Abstract: 2006
      Publication year: 2006
      Source:Advances in Molecular and Cell Biology, Volume 37

      We outline the physical conditions that enable cytoskeletal polymers, such as actin filaments (AFs) and microtubules, to act as electrical transmission lines for ion flows along their lengths. For AFs we propose a model in which each protein subunit is an electric element with a capacitive, inductive, and resistive property due to the molecular structure of the filament and viscosity of the solution. Based on the conductivity rules that apply to electrical circuits, we discuss the properties of ionic waves that propagate along actin filaments. We then discuss the dynamics of C‐termini states in microtubules and their networks, including the interactions with ions and signal transmission via microtubule‐associated proteins. Experiments on ionic conductivity along AFs and microtubules validate the basic assumptions postulated in our models. As a consequence of these results we propose a new signaling mechanism in the cell, especially in neurons, that involves clouds of ions surrounding protein filaments which may travel without significant decay along the axon or the dendritic tree. These signals may be utilized to control various membrane properties, for example, the transition rate of ion channel opening and closing, local membrane conductivity, and vesicle trafficking.

      PubDate: 2012-12-17T07:19:13Z
       
  • The Functional Role of Actin Cytoskeleton Dynamics and Signaling
    • Abstract: 2006
      Publication year: 2006
      Source:Advances in Molecular and Cell Biology, Volume 37

      In this chapter we summarize experimental evidence supporting the hypothesis that rapid modifications of actin cytoskeleton dynamics may represent cellular sensory machinery, receiving extracellular signals and mediating early cell responses. A model “from structure to function” for actin cytoskeleton dynamics and signaling is presented. Nongenomic signaling pathways triggering rapid actin reorganization are analyzed and their regulatory role in various cell functions is discussed. The emerging data thus obtained on impaired actin cytoskeleton dynamics and signaling in malignant cells are addressed and potential strategies that can be applied for the manipulation of cancer cells based on these findings are provided. It is concluded that rapid modifications of actin cytoskeleton dynamics regulated by specific signaling pathways play a pivotal role in early nongenomic cell responses. Studying and understanding actin dynamics and signaling in malignant cells may represent a novel and challenging domain for cancer treatment in the future.

      PubDate: 2012-12-17T07:19:13Z
       
  • Regulation of the Actin Cytoskeleton by Phospholipids
    • Abstract: 2006
      Publication year: 2006
      Source:Advances in Molecular and Cell Biology, Volume 37

      The actin cytoskeleton plays a central role in various motile and morphogenetic cellular and developmental processes. The assembly and disassembly of actin filaments during these processes are precisely controlled by an array of actin‐binding proteins (ABPs). Studies have shown that phosphoinositides, especially PI(4,5)P2 and PI(3,4,5)P3, regulate the activities of many ABPs in vitro and have key roles in actin‐dependent cellular processes such as cytokinesis, phagocytosis, endocytosis, and cell migration. These phosphoinositides typically downregulate the activities of proteins promoting actin filament disassembly and upregulate proteins promoting actin filament assembly. Thus, PI(4,5)P2 and PI(3,4,5)P3 induce actin filament assembly both in vitro and in a number of distinct cellular processes.

      PubDate: 2012-12-17T07:19:13Z
       
  • Lipid Interactions of Cytoskeletal Proteins
    • Abstract: 2006
      Publication year: 2006
      Source:Advances in Molecular and Cell Biology, Volume 37

      At least 18 different cytoskeletal proteins have been shown to interact in vitro with, and in some cases are regulated by, specific membrane lipids, mostly phosphoinositides, whose synthesis is themselves regulated by extracellular signals. These lipid interactions are mediated by structurally diverse specific binding sites. Lipid interactions can serve to target proteins, such as spectrin, myosin X, dynamin, or annexin 2, to the plasma membrane or inactivate processes counteracting actin polymerization and stimulate proteins, such as Wiskott–Aldrich syndrome protein (WASP), involved in nucleating actin polymerization. In other cases (ezrin, talin), phosphoinositides serve to activate proteins involved in actin‐membrane linkage. Such interactions may occur highly localized in lipid rafts.

      PubDate: 2012-12-17T07:19:13Z
       
  • Embryo Morphogenesis and the Role of the Actin Cytoskeleton
    • Abstract: 2006
      Publication year: 2006
      Source:Advances in Molecular and Cell Biology, Volume 37

      During embryogenesis, the tissues of the developing embryo must be bent, tugged, and sculpted in a series of morphogenetic episodes that flow from one to another to generate the final shape of the fetus. The mechanisms underlying these events share startling similarities across a great variety of animals. A primary component of morphogenesis is the actin cytoskeleton, which drives all of the cell shape changes, the tissue bending, and the fusion events that characterize embryogenesis. In this chapter we explore how regulation of the actin cytoskeleton contributes to morphogenetic episodes in worm, fly, fish, mouse, and chick embryos. In particular, we focus on how each of the different structures formed by actin function in morphogenesis and consider how recent research has expanded our knowledge of this area.

      PubDate: 2012-12-17T07:19:13Z
       
  • Mechanisms of Ion Transport Regulation by Microfilaments
    • Abstract: 2006
      Publication year: 2006
      Source:Advances in Molecular and Cell Biology, Volume 37

      A major function of transporting epithelia is vectorial ion movement. This is accomplished by ion channels, pumps, antiporters, and symporters. The activity of these transport proteins is regulated by diverse signaling transduction and membrane trafficking events, many of which involve the actin cytoskeleton. This chapter will focus on the role of actin microfilaments and associated proteins in regulation of ion transport. The apical Na+H+ antiporter NHE3 will be examined in detail in this context due to its general biological importance as well as recent advances that have helped to elucidate the mechanisms of regulation of this protein. Appreciation of the mechanisms of NHE3 regulation should serve as a framework with which to understand cytoskeletal regulation of other transport proteins as well.

      PubDate: 2012-12-17T07:19:13Z
       
  • Domain‐Specific Phosphorylation as a Regulator of Intermediate
           Filaments
    • Abstract: 2006
      Publication year: 2006
      Source:Advances in Molecular and Cell Biology, Volume 37

      Intermediate filaments (IFs) are cytoskeletal structures that maintain cell and tissue integrity. In addition, they have been implicated in a number of other functions, including maintenance of cell shape, subcellular organelle positioning, support to cell migration, radial growth of axons, and scaffolding of signaling molecules. Many of the recognized tasks are affected by phosphorylation, which is the key mechanism to regulate both the organization of IFs and the association of IFs with interacting molecules. Another important function of IF phosphorylation is the disassembly of cytoplasmic and karyoskeletal IF networks during mitosis. An intriguing feature of IFs is the tripartite structure of their building blocks, with a highly conserved central rod domain, which is flanked by variable length N‐ and C‐terminal regions. While the rod domain is crucial for the assembly of IFs, a common feature of the distal domains is that they represent the main targets of phosphorylation. Since phosphate targeting seems to have domain‐specific functions, this chapter aims at summarizing the different roles of N‐ and C‐terminal phosphorylation of IFs.

      PubDate: 2012-12-17T07:19:13Z
       
  • Contributors to Volume 37
    • Abstract: 2006
      Publication year: 2006
      Source:Advances in Molecular and Cell Biology, Volume 37



      PubDate: 2012-12-17T07:19:13Z
       
  • Abbreviations and Acronyms
    • Abstract: 2006
      Publication year: 2006
      Source:Advances in Molecular and Cell Biology, Volume 37



      PubDate: 2012-12-17T07:19:13Z
       
  • Chapter 1 Lipid Rafts and Caveolae Organization
    • Abstract: 2005
      Publication year: 2005
      Source:Advances in Molecular and Cell Biology, Volume 36



      PubDate: 2012-12-17T07:19:13Z
       
  • Chapter 2 Caveolae and the Regulation of Cellular Cholesterol Homeostasis
    • Abstract: 2005
      Publication year: 2005
      Source:Advances in Molecular and Cell Biology, Volume 36



      PubDate: 2012-12-17T07:19:13Z
       
  • Chapter 3 The Caveolae Internalization Machinery
    • Abstract: 2005
      Publication year: 2005
      Source:Advances in Molecular and Cell Biology, Volume 36



      PubDate: 2012-12-17T07:19:13Z
       
  • Chapter 4 Lipid Raft-Mediated Entry of Bacteria into Host Cells
    • Abstract: 2005
      Publication year: 2005
      Source:Advances in Molecular and Cell Biology, Volume 36



      PubDate: 2012-12-17T07:19:13Z
       
  • Chapter 5 The Caveolin Interaction with Endothelial Nitric Oxide Synthase
           (eNOS)
    • Abstract: 2005
      Publication year: 2005
      Source:Advances in Molecular and Cell Biology, Volume 36



      PubDate: 2012-12-17T07:19:13Z
       
  • Chapter 6 Caveolae and Estrogen Receptor Signaling
    • Abstract: 2005
      Publication year: 2005
      Source:Advances in Molecular and Cell Biology, Volume 36



      PubDate: 2012-12-17T07:19:13Z
       
  • Chapter 7 eNOS Regulation by Sphingosine 1-Phosphate and Caveolin
    • Abstract: 2005
      Publication year: 2005
      Source:Advances in Molecular and Cell Biology, Volume 36



      PubDate: 2012-12-17T07:19:13Z
       
  • Chapter 8 Insulin Signaling and Caveolae
    • Abstract: 2005
      Publication year: 2005
      Source:Advances in Molecular and Cell Biology, Volume 36



      PubDate: 2012-12-17T07:19:13Z
       
  • Chapter 9 Caveolin-3, Caveolae, and Hereditary Muscle Diseases
    • Abstract: 2005
      Publication year: 2005
      Source:Advances in Molecular and Cell Biology, Volume 36



      PubDate: 2012-12-17T07:19:13Z
       
  • Chapter 10 Caveolae and Caveolins in the Vascular System: Functional Roles
           in Endothelia, Macrophages, and Smooth Muscle Cells
    • Abstract: 2005
      Publication year: 2005
      Source:Advances in Molecular and Cell Biology, Volume 36



      PubDate: 2012-12-17T07:19:13Z
       
  • Chapter 11 Caveolin Proteins in Cardiopulmonary Disease and Lung Cancers
    • Abstract: 2005
      Publication year: 2005
      Source:Advances in Molecular and Cell Biology, Volume 36



      PubDate: 2012-12-17T07:19:13Z
       
 
 
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