Subjects -> BIOLOGY (Total: 3496 journals)
    - BIOCHEMISTRY (269 journals)
    - BIOENGINEERING (143 journals)
    - BIOLOGY (1679 journals)
    - BIOPHYSICS (50 journals)
    - BIOTECHNOLOGY (272 journals)
    - BOTANY (252 journals)
    - CYTOLOGY AND HISTOLOGY (32 journals)
    - ENTOMOLOGY (77 journals)
    - GENETICS (171 journals)
    - MICROBIOLOGY (292 journals)
    - MICROSCOPY (12 journals)
    - ORNITHOLOGY (29 journals)
    - PHYSIOLOGY (73 journals)
    - ZOOLOGY (145 journals)

BIOLOGY (1679 journals)                  1 2 3 4 5 6 7 8 | Last

Showing 1 - 200 of 1720 Journals sorted alphabetically
AAPS Journal     Hybrid Journal   (Followers: 34)
Achievements in the Life Sciences     Open Access   (Followers: 10)
ACS Pharmacology & Translational Science     Hybrid Journal   (Followers: 4)
ACS Synthetic Biology     Hybrid Journal   (Followers: 35)
Acta Biologica Colombiana     Open Access   (Followers: 7)
Acta Biologica Hungarica     Full-text available via subscription   (Followers: 6)
Acta Biologica Sibirica     Open Access   (Followers: 2)
Acta Biologica Turcica     Open Access   (Followers: 1)
Acta Biologica Venezuelica     Open Access  
Acta Biomaterialia     Hybrid Journal   (Followers: 33)
Acta Biotheoretica     Hybrid Journal   (Followers: 4)
Acta Chiropterologica     Full-text available via subscription   (Followers: 5)
acta ethologica     Hybrid Journal   (Followers: 4)
Acta Fytotechnica et Zootechnica     Open Access   (Followers: 1)
Acta Limnologica Brasiliensia     Open Access   (Followers: 4)
Acta Médica Costarricense     Open Access   (Followers: 2)
Acta Musei Silesiae, Scientiae Naturales     Open Access   (Followers: 3)
Acta Neurobiologiae Experimentalis     Open Access  
Acta Parasitologica     Hybrid Journal   (Followers: 13)
Acta Scientiae Biological Research     Open Access   (Followers: 1)
Acta Scientiarum. Biological Sciences     Open Access   (Followers: 3)
Acta Scientifica Naturalis     Open Access   (Followers: 3)
Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis     Open Access   (Followers: 1)
Acta Universitatis Lodziensis, Folia Biologica et Oecologica     Open Access   (Followers: 1)
Actualidades Biológicas     Open Access   (Followers: 2)
Advanced Biosystems     Hybrid Journal  
Advanced Health Care Technologies     Open Access   (Followers: 11)
Advanced Journal of Graduate Research     Open Access   (Followers: 2)
Advanced Nonlinear Studies     Hybrid Journal  
Advanced Quantum Technologies     Hybrid Journal  
Advanced Studies in Biology     Open Access   (Followers: 2)
Advances in Antiviral Drug Design     Full-text available via subscription   (Followers: 2)
Advances in Bioinformatics     Open Access   (Followers: 20)
Advances in Biological Regulation     Hybrid Journal   (Followers: 4)
Advances in Biology     Open Access   (Followers: 11)
Advances in Biosensors and Bioelectronics     Open Access   (Followers: 9)
Advances in Cell Biology/ Medical Journal of Cell Biology     Open Access   (Followers: 30)
Advances in Cellular and Molecular Biology of Membranes and Organelles     Full-text available via subscription   (Followers: 14)
Advances in Developmental Biology     Full-text available via subscription   (Followers: 14)
Advances in DNA Sequence-Specific Agents     Full-text available via subscription   (Followers: 8)
Advances in Ecological Research     Full-text available via subscription   (Followers: 45)
Advances in Environmental Sciences - International Journal of the Bioflux Society     Open Access   (Followers: 20)
Advances in Enzyme Research     Open Access   (Followers: 12)
Advances in Experimental Biology     Full-text available via subscription   (Followers: 10)
Advances in Genome Biology     Full-text available via subscription   (Followers: 12)
Advances in High Energy Physics     Open Access   (Followers: 26)
Advances in Human Biology     Open Access   (Followers: 5)
Advances in Life Science and Technology     Open Access   (Followers: 21)
Advances in Life Sciences     Open Access   (Followers: 8)
Advances in Marine Biology     Full-text available via subscription   (Followers: 22)
Advances in Molecular and Cell Biology     Full-text available via subscription   (Followers: 28)
Advances in Organ Biology     Full-text available via subscription   (Followers: 3)
Advances in Planar Lipid Bilayers and Liposomes     Full-text available via subscription   (Followers: 3)
Advances in Space Biology and Medicine     Full-text available via subscription   (Followers: 7)
Advances in Structural Biology     Full-text available via subscription   (Followers: 6)
Advances in Tropical Biodiversity and Environmental Sciences     Open Access   (Followers: 3)
Advances in Virus Research     Full-text available via subscription   (Followers: 6)
Adversity and Resilience Science : Journal of Research and Practice     Hybrid Journal   (Followers: 3)
African Journal of Range & Forage Science     Hybrid Journal   (Followers: 13)
AFRREV STECH : An International Journal of Science and Technology     Open Access   (Followers: 4)
Ageing Research Reviews     Hybrid Journal   (Followers: 13)
Aging Cell     Open Access   (Followers: 27)
Agrokémia és Talajtan     Full-text available via subscription   (Followers: 3)
Agrokreatif Jurnal Ilmiah Pengabdian kepada Masyarakat     Open Access   (Followers: 1)
AJP Cell Physiology     Hybrid Journal   (Followers: 19)
AJP Endocrinology and Metabolism     Hybrid Journal   (Followers: 26)
AJP Lung Cellular and Molecular Physiology     Hybrid Journal   (Followers: 3)
Al-Kauniyah : Jurnal Biologi     Open Access   (Followers: 1)
Alasbimn Journal     Open Access   (Followers: 2)
Alces : A Journal Devoted to the Biology and Management of Moose     Open Access  
AMB Express     Open Access   (Followers: 1)
Ambix     Hybrid Journal   (Followers: 3)
American Biology Teacher     Full-text available via subscription   (Followers: 14)
American Fern Journal     Full-text available via subscription   (Followers: 1)
American Journal of Agricultural and Biological Sciences     Open Access   (Followers: 9)
American Journal of Bioethics     Hybrid Journal   (Followers: 19)
American Journal of Human Biology     Hybrid Journal   (Followers: 18)
American Journal of Medical and Biological Research     Open Access   (Followers: 11)
American Journal of Plant Sciences     Open Access   (Followers: 23)
American Journal of Primatology     Hybrid Journal   (Followers: 17)
American Malacological Bulletin     Full-text available via subscription   (Followers: 3)
American Naturalist     Full-text available via subscription   (Followers: 82)
Amphibia-Reptilia     Hybrid Journal   (Followers: 5)
Anadol University Journal of Science and Technology B : Theoritical Sciences     Open Access  
Anadolu University Journal of Science and Technology : C Life Sciences and Biotechnology     Open Access   (Followers: 2)
Anaerobe     Hybrid Journal   (Followers: 4)
Anales de Biología     Open Access   (Followers: 3)
Analytical Methods     Full-text available via subscription   (Followers: 13)
Anatomical Science International     Hybrid Journal   (Followers: 3)
Animal Cells and Systems     Hybrid Journal   (Followers: 5)
Animal Models and Experimental Medicine     Open Access  
Annales de Limnologie - International Journal of Limnology     Hybrid Journal   (Followers: 1)
Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale     Full-text available via subscription   (Followers: 3)
Annales Henri Poincaré     Hybrid Journal   (Followers: 3)
Annales Universitatis Mariae Curie-Sklodowska, sectio C – Biologia     Open Access   (Followers: 1)
Annals of Applied Biology     Hybrid Journal   (Followers: 8)
Annals of Biomedical Engineering     Hybrid Journal   (Followers: 19)
Annals of Human Biology     Hybrid Journal   (Followers: 6)
Annals of Science and Technology     Open Access   (Followers: 1)
Annual Research & Review in Biology     Open Access   (Followers: 2)
Annual Review of Biomedical Engineering     Full-text available via subscription   (Followers: 16)
Annual Review of Biophysics     Full-text available via subscription   (Followers: 26)
Annual Review of Cancer Biology     Full-text available via subscription   (Followers: 4)
Annual Review of Cell and Developmental Biology     Full-text available via subscription   (Followers: 42)
Annual Review of Food Science and Technology     Full-text available via subscription   (Followers: 15)
Annual Review of Genomics and Human Genetics     Full-text available via subscription   (Followers: 28)
Annual Review of Phytopathology     Full-text available via subscription   (Followers: 14)
Anthropological Review     Open Access   (Followers: 27)
Antibiotics     Open Access   (Followers: 9)
Antioxidants     Open Access   (Followers: 5)
Antioxidants & Redox Signaling     Hybrid Journal   (Followers: 9)
Antonie van Leeuwenhoek     Hybrid Journal   (Followers: 5)
Anzeiger für Schädlingskunde     Hybrid Journal   (Followers: 1)
Apidologie     Hybrid Journal   (Followers: 5)
Apmis     Hybrid Journal   (Followers: 2)
APOPTOSIS     Hybrid Journal   (Followers: 9)
Applied Biology     Open Access   (Followers: 2)
Applied Bionics and Biomechanics     Open Access   (Followers: 7)
Applied Vegetation Science     Full-text available via subscription   (Followers: 10)
Aquaculture Environment Interactions     Open Access   (Followers: 5)
Aquaculture International     Hybrid Journal   (Followers: 26)
Aquaculture Reports     Open Access   (Followers: 3)
Aquaculture, Aquarium, Conservation & Legislation - International Journal of the Bioflux Society     Open Access   (Followers: 7)
Aquatic Biology     Open Access   (Followers: 9)
Aquatic Ecology     Hybrid Journal   (Followers: 40)
Aquatic Ecosystem Health & Management     Hybrid Journal   (Followers: 15)
Aquatic Science and Technology     Open Access   (Followers: 4)
Aquatic Toxicology     Hybrid Journal   (Followers: 24)
Arabian Journal of Scientific Research / المجلة العربية للبحث العلمي     Open Access   (Followers: 1)
Archaea     Open Access   (Followers: 4)
Archiv für Molluskenkunde: International Journal of Malacology     Full-text available via subscription   (Followers: 3)
Archives of Biological Sciences     Open Access  
Archives of Microbiology     Hybrid Journal   (Followers: 10)
Archives of Natural History     Hybrid Journal   (Followers: 8)
Archives of Oral Biology     Hybrid Journal   (Followers: 3)
Archives of Virology     Hybrid Journal   (Followers: 5)
Archivum Immunologiae et Therapiae Experimentalis     Hybrid Journal   (Followers: 2)
Arctic     Open Access   (Followers: 9)
Arid Ecosystems     Hybrid Journal   (Followers: 3)
Arquivos do Instituto Biológico     Open Access   (Followers: 1)
Arquivos do Museu Dinâmico Interdisciplinar     Open Access  
Arthropod Structure & Development     Hybrid Journal   (Followers: 2)
Arthropods     Open Access   (Followers: 1)
Artificial DNA: PNA & XNA     Hybrid Journal   (Followers: 3)
Asian Bioethics Review     Full-text available via subscription   (Followers: 4)
Asian Journal of Biodiversity     Open Access   (Followers: 5)
Asian Journal of Biological Sciences     Open Access   (Followers: 4)
Asian Journal of Biology     Open Access   (Followers: 3)
Asian Journal of Biotechnology and Bioresource Technology     Open Access   (Followers: 3)
Asian Journal of Cell Biology     Open Access   (Followers: 7)
Asian Journal of Developmental Biology     Open Access   (Followers: 4)
Asian Journal of Medical and Biological Research     Open Access   (Followers: 5)
Asian Journal of Nematology     Open Access   (Followers: 4)
Asian Journal of Poultry Science     Open Access   (Followers: 5)
Atti della Accademia Peloritana dei Pericolanti - Classe di Scienze Medico-Biologiche     Open Access  
Australian Life Scientist     Full-text available via subscription   (Followers: 2)
Australian Mammalogy     Hybrid Journal   (Followers: 8)
Autophagy     Hybrid Journal   (Followers: 6)
Avian Biology Research     Full-text available via subscription   (Followers: 6)
Avian Conservation and Ecology     Open Access   (Followers: 16)
Bacterial Empire     Open Access   (Followers: 2)
Bacteriology Journal     Open Access   (Followers: 1)
Bacteriophage     Full-text available via subscription   (Followers: 3)
Bangladesh Journal of Bioethics     Open Access  
Bangladesh Journal of Plant Taxonomy     Open Access  
Bangladesh Journal of Scientific Research     Open Access   (Followers: 1)
Batman Üniversitesi Yaşam Bilimleri Dergisi     Open Access  
Berita Biologi     Open Access   (Followers: 1)
Between the Species     Open Access   (Followers: 1)
Bio Tribune Magazine     Hybrid Journal  
BIO Web of Conferences     Open Access  
BIO-Complexity     Open Access  
Bio-Grafía. Escritos sobre la Biología y su enseñanza     Open Access  
Bio-Lectura     Open Access  
BIO-SITE : Biologi dan Sains Terapan     Open Access   (Followers: 1)
Bioactive Compounds in Health and Disease     Open Access  
Bioanalytical Reviews     Hybrid Journal   (Followers: 2)
Biocatalysis and Biotransformation     Hybrid Journal   (Followers: 6)
BioCentury Innovations     Full-text available via subscription   (Followers: 2)
Biochemistry and Cell Biology     Hybrid Journal   (Followers: 16)
Biochimie     Hybrid Journal   (Followers: 5)
BioControl     Hybrid Journal   (Followers: 5)
Biocontrol Science and Technology     Hybrid Journal   (Followers: 8)
Biodemography and Social Biology     Hybrid Journal  
BIODIK : Jurnal Ilmiah Pendidikan Biologi     Open Access   (Followers: 1)
BioDiscovery     Open Access   (Followers: 2)
Biodiversidade e Conservação Marinha : Revista CEPSUL     Open Access  
Biodiversitas : Journal of Biological Diversity     Open Access  
Biodiversity : Research and Conservation     Open Access   (Followers: 28)
Biodiversity Data Journal     Open Access   (Followers: 5)
Biodiversity Informatics     Open Access   (Followers: 1)
Biodiversity Information Science and Standards     Open Access   (Followers: 2)
Bioedukasi : Jurnal Pendidikan Biologi FKIP UM Metro     Open Access   (Followers: 1)
Bioeksperimen : Jurnal Penelitian Biologi     Open Access  
Bioelectrochemistry     Hybrid Journal   (Followers: 1)
Bioelectromagnetics     Hybrid Journal   (Followers: 2)
Bioenergy Research     Hybrid Journal   (Followers: 3)
Bioengineering and Bioscience     Open Access   (Followers: 3)
BioEssays     Hybrid Journal   (Followers: 10)
Bioethica     Open Access   (Followers: 2)

        1 2 3 4 5 6 7 8 | Last

Similar Journals
Journal Cover
Biochemistry and Cell Biology
Journal Prestige (SJR): 0.856
Citation Impact (citeScore): 2
Number of Followers: 16  
 
  Hybrid Journal Hybrid journal (It can contain Open Access articles)
ISSN (Print) 0829-8211 - ISSN (Online) 1208-6002
Published by NRC Research Press Homepage  [21 journals]
  • Long-term treatment with insulin and retinoic acid increased glucose
           utilization in L6 muscle cells via glycogenesis
    • Authors: Matthew Goff, Guoxun Chen
      Pages: 1 - 15
      Abstract: Biochemistry and Cell Biology, Ahead of Print.
      The skeletal muscle regulates glucose homeostasis. Here, the effects of vitamin A metabolites including retinoic acid (RA) alone, and in combination with insulin, on glucose utilization were investigated in rat L6 muscle cells during the differentiation process. L6 cells were treated with differentiation medium containing retinol, retinal, RA, and (or) insulin. The glucose levels and pH values in the medium were measured every 2 days. The expression levels of insulin signaling and glycogen synthesis proteins, as well as glycogen content were determined. Retinal and RA reduced the glucose content and pH levels in the medium of the L6 cells. RA acted synergistically with insulin to reduce glucose and pH levels in the medium. The RA- and insulin-mediated reduction of glucose in the medium only occurred when glucose levels were at or above 15 mmol/L. Insulin-induced phosphorylation of Akt Thr308 was further enhanced by RA treatment through the activation of retinoic acid receptor. RA acted synergistically with insulin to phosphorylate glycogen synthase kinase 3β, and dephosphorylate glycogen synthase (GS), which was associated with increases in the protein and mRNA levels of GS. Increases in glycogen content were induced by insulin, and was further enhanced in the presence of RA. We conclude that activation of the RA signaling pathway enhanced insulin-induced glucose utilization in differentiating L6 cells through increases in glycogenesis.
      Citation: Biochemistry and Cell Biology
      PubDate: 2020-11-20T12:10:59Z
      DOI: 10.1139/bcb-2020-0131
       
  • Long noncoding RNA RP11-909N17.2 promotes proliferation, invasion, and
           migration of hepatocellular carcinoma by regulating microRNA-767-3p
    • Authors: Qiang Liu, She-Jiao Dai, Lei Dong, Hong Li
      Pages: 1 - 10
      Abstract: Biochemistry and Cell Biology, Ahead of Print.
      Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related deaths worldwide, especially in developing countries. Although advances in surgical procedures and targeted medicine have improved the overall survival of patients with HCC, the prognosis is poor. Hence, there is a need to identify novel therapeutic targets for HCC. Here, we report that the expression of RP11-909N17.2, a novel, long, noncoding RNA (lncRNA), is dysregulated in patients with HCC and cell lines. Additionally, this study demonstrated that RP11-909N17.2 facilitates the proliferation and invasion of HCC cells by binding to miRNA-767-3p, a tumor-suppressive microRNA (miRNA). Small integral membrane protein 7 (SMIM7) was identified as the downstream target of miRNA-767-3p. The expression of SMIM7 was upregulated in HCC clinical samples and cell lines. Moreover, SMIM7 was involved in the proliferation and invasion of HCC cells. Furthermore, SMIM7 inhibited the apoptosis of HCC cells, which indicated the oncogenic role of SMIM7 in HCC. The findings of this study suggest that the lncRNA–miRNA–mRNA regulatory axis, which regulates the pathogenesis of HCC, can be a potential novel diagnostic and therapeutic target for HCC.
      Citation: Biochemistry and Cell Biology
      PubDate: 2020-11-19T08:00:00Z
      DOI: 10.1139/bcb-2019-0362
       
  • Amplified LncRNA PVT1 promotes lung cancer proliferation and metastasis by
           facilitating VEGFC expression
    • Authors: Yanming Pan, Lantao Liu, Yongxia Cheng, Jianbo Yu, Yukuan Feng
      Pages: 1 - 7
      Abstract: Biochemistry and Cell Biology, Ahead of Print.
      Although the abundance of long non-coding RNA (lncRNA) plasmacytoma variant translocation 1 (PVT1) in lung cancer has been well researched, the underlying mechanisms behind its effects were unknown. Here we investigated the molecular events regulating PVT1 in lung cancer. The pro-proliferative property of PVT1 was examined using a xenograft tumor model. Transwell chambers were used to analyze the impact of PVT1 expression on cell invasiveness and migration. In vivo metastasis was examined by tail-vein-injection in mice. Direct binding of miR-128 to PVT1 was investigated using a probe pulldown assay. The relative expression levels of miR-128 and PVT1 were quantified by real-time polymerase chain reaction and Western blotting. We show here that when PVT1 is amplified, there is a poor survival prognosis for patients with lung cancer. Elevated levels of PVT1 promoted lung cancer cell proliferation and metastasis, both in vitro and in vivo. Mechanistically, we found that PVT1 competes endogenously with miR-128 in the regulation of vascular endothelial growth factor C (VEGFC) expression, which is significantly associated with an unfavorable prognosis in lung cancer. We identified that copy number amplification significantly contributes to the high level of PVT1 transcripts in lung cancer, which promotes cell proliferation and metastatic behavior via modulating VEGFC expression by endogenous competition with miR-128.
      Citation: Biochemistry and Cell Biology
      PubDate: 2020-11-09T08:00:00Z
      DOI: 10.1139/bcb-2019-0435
       
  • lncRNA CTBP1-AS2 promotes proliferation and migration of glioma by
           modulating miR-370-3p–Wnt7a-mediated epithelial–mesenchymal transition
           
    • Authors: Yongfeng Li, Jin Zong, Cong Zhao
      Pages: 1 - 8
      Abstract: Biochemistry and Cell Biology, Ahead of Print.
      Glioma is one of the most common and aggressive malignant primary brain tumors, with a poor 5-year survival rate. The long noncoding RNA (lncRNA) CTBP1-AS2 has been shown to be correlated with the prognosis of cancer, but the role of CTBP1-AS2 in glioma and its concrete mechanism is fully unknown. The clinical data and tissues of glioma patients were analyzed. Cell viability and migration assays were performed. Western blotting and qRT-PCR were adopted for investigation of target protein expressions. Double luciferase assay was used to investigate the interaction between different elements. The lncRNA CTBP1-AS2 had increased expression profiles in tumor tissues, which is associated with poor prognosis. In detail, CTBP1-AS2 knockdown decreased proliferation and migration phenotypes in both U87-MG and LN229 cells. Moreover, CTBP1-AS2 knockdown suppressed the key epithelial–mesenchymal transition (EMT) markers by downregulating Wnt7a-mediated signaling. Furthermore, miR-370-3p functioned as a link that could be absorbed by CTBP1-AS2, thus regulating Wnt7a expression. Lastly, the CTBP1-AS2–miR-370-3p–Wnt7a axis modulated EMT in glioma cells in vitro and in vivo. This study provides new insights that a novel lncRNA, CTBP1-AS2, regulates EMT of glioma by modulating the miR-370-3p–Wnt7a axis.
      Citation: Biochemistry and Cell Biology
      PubDate: 2020-11-05T08:00:00Z
      DOI: 10.1139/bcb-2020-0065
       
  • TET2 expedites coronary heart disease by promoting microRNA-126 expression
           and inhibiting the E2F3–PI3K–AKT axis
    • Authors: Yan Xu
      Pages: 1 - 11
      Abstract: Biochemistry and Cell Biology, Ahead of Print.
      DNA demethylases of the ten-eleven translocation (TET) family serve as tumor suppressors in various human cancers, but their pathogenic effects in coronary heart disease (CHD) remain unclear. Here we report that TET2 is transcriptionally upregulated in CHD patients, where it shows potential as a diagnostic tool. Mechanistic investigations revealed that TET2 facilitates inflammatory responses and cardiomyocyte apoptosis in rats through demethylation of microRNA-126 (miR-126) promoter. This interaction leads to sequestration of miR-126 from its target E2F transcription factor 3 (E2F3), contributing to E2F3 suppression in CHD. Upregulation of miR-126 when TET2 was silenced restored levels of inflammatory factors and aggravated the degree of cardiac injury and cardiomyocyte apoptosis in rats. By contrast, simultaneous overexpression of E2F3 and miR-126 reduced the levels of inflammatory factors, cardiac injury, and cardiomyocyte apoptosis in rats. Also, TET2 was found to regulate the activity of the PI3K–AKT pathway through the miR-126–E2F3 axis. Our findings uncover a novel function for TET2 in facilitating the progression of CHD.
      Citation: Biochemistry and Cell Biology
      PubDate: 2020-08-20T07:00:00Z
      DOI: 10.1139/bcb-2020-0297
       
  • Beyond the genome: challenges and potential for epigenetics-driven
           therapeutic approaches in pulmonary arterial hypertension
    • Authors: Jessica Y. Hsu, Jennifer L. Major, Andrew S. Riching, Rwik Sen, Julie Pires da Silva, Rushita A. Bagchi
      Pages: 1 - 16
      Abstract: Biochemistry and Cell Biology, Ahead of Print.
      Pulmonary arterial hypertension (PAH) is a devastating disease of the cardiopulmonary system caused by the narrowing of the pulmonary arteries, leading to increased vascular resistance and pressure. This leads to right ventricle remodeling, dysfunction, and eventually, death. While conventional therapies have largely focused on targeting vasodilation, other pathological features of PAH including aberrant inflammation, mitochondrial dynamics, cell proliferation, and migration have not been well explored. Thus, despite some recent improvements in PAH treatment, the life expectancy and quality of life for patients with PAH remains poor. Showing many similarities to cancers, PAH is characterized by increased pulmonary arterial smooth muscle cell proliferation, decreased apoptotic signaling pathways, and changes in metabolism. The recent successes of therapies targeting epigenetic modifiers for the treatment of cancer has prompted epigenetic research in PAH, revealing many new potential therapeutic targets. In this minireview we discuss the emergence of epigenetic dysregulation in PAH and highlight epigenetic-targeting compounds that may be effective for the treatment of PAH.
      Citation: Biochemistry and Cell Biology
      PubDate: 2020-07-24T07:00:00Z
      DOI: 10.1139/bcb-2020-0039
       
  • Inhibition of long noncoding RNA MALAT1 suppresses high glucose-induced
           apoptosis and inflammation in human umbilical vein endothelial cells by
           suppressing the NF-κB signaling pathway
    • Authors: Yu-Ping Gong, Ya-Wei Zhang, Xiao-Qing Su, Hai-Bo Gao
      Pages: 1 - 7
      Abstract: Biochemistry and Cell Biology, Ahead of Print.
      The study investigated the expression of long noncoding RNA (lncRNA) MALAT1 in high glucose (HG)-induced human vascular endothelial cells (HUVECs) and the role of MALAT1 in the apoptosis of HG-induced HUVECs. The HUVECs were cultured and induced with 25 mmol/L HG. After that, the HUVECs were transfected with MALAT1 siRNA. The expression levels of MALAT1 were detected with qPCR, whereas the expression levels of Bax, Bcl-2, cleaved-caspase-3, cleaved-caspase-9, p-65, and p-p65 were detected using Western blot. The roles of MALAT1 in cell activities, including apoptosis, were evaluated using the CCK-8 assay, TUNEL staining, and flow cytometry. The expression levels of inflammatory factors (TNF-α and IL-6) were measured using ELISA. The expression levels of MALAT1, TNF-α, and IL-6 in HUVECs were increased in the HG environment; however, when MALAT1 was silenced in the HUVECs, cell proliferation increased significantly, the expression levels of TNF-α, IL-6, Bax, cleaved-caspase-3, and cleaved-caspase-9 decreased, and the rate of apoptosis also decreased. Silencing MALAT1 inhibited the expression of p-p65 in HG-induced HUVECs. In conclusion, our study demonstrated that MALAT1 is upregulated in HG-induced HUVECs, and inhibition of MALAT1 inhibits HG-induced apoptosis and inflammation in HUVECs by suppression of the NF-κB signaling pathway.
      Citation: Biochemistry and Cell Biology
      PubDate: 2020-06-05T07:00:00Z
      DOI: 10.1139/bcb-2019-0403
       
  • Lactoferrin levels in cervical fluid from in vitro fertilization (IVF)
           patients — correlation with IVF parameters
    • Authors: Estefanía Massa, Fabián Pelusa, Agustina Lo Celso, María José Madariaga, Luciana Filocco, Carlos Morente, Sergio Ghersevich
      Pages: 1 - 6
      Abstract: Biochemistry and Cell Biology, Ahead of Print.
      Since our previous results suggest that lactoferrin (LF) might have roles in the reproductive process and that its levels might change in the female tract as a response to various factors, the aim of this investigation was to assess whether LF levels in cervical secretions correlate with reproductive parameters from in vitro fertilization (IVF) patients. Cervical fluid samples were obtained from 34 women under 40 years old enrolled for assisted reproduction techniques, and LF concentration was measured. The mean total protein concentration in all cervical fluid samples was 842.8 ± 116.9 µg/mL. The mean concentration of LF was 0.73 ± 0.06 ng LF/µg of total proteins. We observed that higher LF levels in cervical fluid correlated with lower IVF rates when all patients were analyzed; this negative correlation was also sustained when only patients ≥35 years were studied. The mean LF concentration in cervical fluid was significantly lower among patients with normal IVF rates than in those with values 50% or less. Using a LF cutoff value of 0.83 ng/μg of total proteins, the study revealed a significant association between the LF levels below 0.83 ng/µg of total proteins and IVF rates above 50%. LF levels in cervical mucus could potentially be used as a marker of fertilization outcome.
      Citation: Biochemistry and Cell Biology
      PubDate: 2020-05-31T07:00:00Z
      DOI: 10.1139/bcb-2020-0098
       
  • FOXD3 inhibits cell proliferation, migration, and invasion in
           nasopharyngeal carcinoma through regulation of the PI3K–Akt pathway
    • Authors: Xiaoxing Xie, Gaoyun Xiong, Wenjun Chen, Hongdan Fu, Mingqian Li, Xiaoying Cui
      Pages: 1 - 8
      Abstract: Biochemistry and Cell Biology, Ahead of Print.
      FOXD3 has been found previously to positively regulate miR-26b, a tumor inhibitor of nasopharyngeal carcinoma (NPC). However, FOXD3’s precise function and associated mechanism of action in NPC have not yet been investigated. In this study, the expression of FOXD3 mRNA and protein was evaluated using RT-qPCR, western blotting, and immunohistochemistry. Protein levels involved in the phosphoinositide 3-kinase – protein kinase B (PI3K–Akt) pathway were assessed by western blot, and cell proliferation was determined by MTT and colony forming assays. Additionally, cell apoptosis was assessed by flow cytometric assay. Finally, the migration and invasion capabilities of the NPC cells were determined using wound healing and Transwell assays. We found that FOXD3 levels were relatively low in NPC tissue and cells, while an increase caused the inhibition of the PI3K–Akt pathway. Functional experiments found that overexpression of FOXD3 suppressed cell proliferation, migration, and invasion and enhanced cell apoptosis in NPC C6661 cells. IGF-1, an activator of the PI3K–Akt pathway, reversed the inhibitory effect of FOXD3. Furthermore, we found upregulation of the PI3K–Akt pathway and upregulation of the inhibitory effects of FOXD3 on C6661 cellular activities. In conclusion, FOXD3 negatively affected the PI3K–Akt pathway to restrain the processes involved in C6661 cell pathology. These findings further exposed the function and downstream axis of FOXD3 in NPC and displayed a promising new target for NPC therapy.
      Citation: Biochemistry and Cell Biology
      PubDate: 2020-05-27T07:00:00Z
      DOI: 10.1139/bcb-2020-0011
       
  • Lactoferrin and oral pathologies: a therapeutic treatment
    • Authors: Luigi Rosa, Maria Stefania Lepanto, Antimo Cutone, Giusi Ianiro, Stefania Pernarella, Riccardo Sangermano, Giovanni Musci, Livia Ottolenghi, Piera Valenti
      Pages: 1 - 10
      Abstract: Biochemistry and Cell Biology, Ahead of Print.
      The oral cavity is a non-uniform, extraordinary environment characterized by mucosal, epithelial, abiotic surfaces and secretions as saliva. Aerobic and anaerobic commensal and pathogenic microorganisms colonize the tongue, teeth, jowl, gingiva, and periodontium. Commensals exert an important role in host defenses, while pathogenic microorganisms can nullify this protective function causing oral and systemic diseases. Every day, 750–1000 mL of saliva, containing several host defense constituents including lactoferrin (Lf), are secreted and swallowed. Lf is a multifunctional iron-chelating cationic glycoprotein of innate immunity. Depending on, or regardless of its iron-binding ability, Lf exerts bacteriostatic, bactericidal, antibiofilm, antioxidant, antiadhesive, anti-invasive, and anti-inflammatory activities. Here, we report the protective role of Lf in different oral pathologies, such as xerostomia, halitosis, alveolar or maxillary bone damage, gingivitis, periodontitis, and black stain. Unlike antibiotic therapy, which is ineffective against bacteria that are within a biofilm, adherent, or intracellular, the topical administration of Lf, through its simultaneous activity against microbial replication, biofilms, adhesion, and invasiveness, as well as inflammation, has been proven to be efficient in the treatment of all known oral pathologies without any adverse effects.
      Citation: Biochemistry and Cell Biology
      PubDate: 2020-03-26T07:00:00Z
      DOI: 10.1139/bcb-2020-0052
       
  • Eukaryotic initiation factor 5B (eIF5B) regulates temozolomide-mediated
           apoptosis in brain tumour stem cells (BTSCs)
    • Authors: Joseph A. Ross, Bo Young Ahn, Jennifer King, Kamiko R. Bressler, Donna L. Senger, Nehal Thakor
      Pages: 647 - 652
      Abstract: Biochemistry and Cell Biology, Volume 98, Issue 6, Page 647-652, December 2020.
      Glioblastoma multiforme (GBM) is among the deadliest cancers, owing in part to complex inter- and intra-tumor heterogeneity and the presence of a population of stem-like cells called brain tumour stem cells (BTSCs/BTICs). These cancer stem cells survive treatment and confer resistance to the current therapies — namely, radiation and the chemotherapeutic, temozolomide (TMZ). TMZ induces cell death by alkylating DNA, and BTSCs resist this mechanism via a robust DNA damage response. Hence, recent studies aimed to sensitize BTSCs to TMZ using combination therapy, such as inhibition of DNA repair machinery. We have previously demonstrated in established GBM cell lines that eukaryotic initiation factor 5B (eIF5B) promotes the translation of pro-survival and anti-apoptotic proteins. Consequently, silencing eIF5B sensitizes these cells to TRAIL-induced apoptosis. However, established cell lines do not always recapitulate the features of human glioma. Therefore, we investigated this mechanism in patient-derived BTSCs. We show that silencing eIF5B leads to increased TMZ sensitivity in two BTSC lines: BT25 and BT48. Depletion of eIF5B decreases the levels of anti-apoptotic proteins in BT48 and sensitizes these cells to TMZ-induced activation of caspase-3, cleavage of PARP, and apoptosis. We suggest that eIF5B represents a rational target to sensitize GBM tumors to the current standard-of-care.
      Citation: Biochemistry and Cell Biology
      PubDate: 2019-10-31T07:00:00Z
      DOI: 10.1139/bcb-2019-0329
      Issue No: Vol. 98, No. 6 (2019)
       
  • Silencing LINC00511 inhibits cell proliferation, migration, and
           epithelial–mesenchymal transition via the PTEN–AKT–FOXO1 signaling
           pathway in lung cancer
    • Authors: Lianyong Jiang, Xiao Xie, Fangbao Ding, Ju Mei, Rui Bi
      Pages: 1 - 8
      Abstract: Biochemistry and Cell Biology, Ahead of Print.

      Citation: Biochemistry and Cell Biology
      PubDate: 2019-08-15T07:00:00Z
      DOI: 10.1139/bcb-2018-0364
       
 
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