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  Subjects -> BIOLOGY (Total: 3190 journals)
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BIOTECHNOLOGY (244 journals)                  1 2 | Last

Showing 1 - 200 of 244 Journals sorted alphabetically
3 Biotech     Open Access   (Followers: 8)
Advanced Biomedical Research     Open Access  
Advances in Bioscience and Biotechnology     Open Access   (Followers: 17)
Advances in Genetic Engineering & Biotechnology     Hybrid Journal   (Followers: 9)
Advances in Regenerative Medicine     Open Access   (Followers: 3)
African Journal of Biotechnology     Open Access   (Followers: 6)
Algal Research     Partially Free   (Followers: 11)
American Journal of Biochemistry and Biotechnology     Open Access   (Followers: 69)
American Journal of Bioinformatics Research     Open Access   (Followers: 7)
American Journal of Polymer Science     Open Access   (Followers: 33)
Amylase     Open Access  
Anadolu University Journal of Science and Technology : C Life Sciences and Biotechnology     Open Access  
Animal Biotechnology     Hybrid Journal   (Followers: 8)
Annales des Sciences Agronomiques     Full-text available via subscription  
Applied Biochemistry and Biotechnology     Hybrid Journal   (Followers: 45)
Applied Biosafety     Hybrid Journal  
Applied Food Biotechnology     Open Access   (Followers: 3)
Applied Microbiology and Biotechnology     Hybrid Journal   (Followers: 67)
Applied Mycology and Biotechnology     Full-text available via subscription   (Followers: 4)
Arthroplasty Today     Open Access   (Followers: 1)
Artificial Cells, Nanomedicine and Biotechnology     Hybrid Journal   (Followers: 1)
Asia Pacific Biotech News     Hybrid Journal   (Followers: 2)
Asian Journal of Biotechnology     Open Access   (Followers: 9)
Asian Pacific Journal of Tropical Biomedicine     Open Access   (Followers: 2)
Australasian Biotechnology     Full-text available via subscription   (Followers: 1)
Banat's Journal of Biotechnology     Open Access  
BBR : Biochemistry and Biotechnology Reports     Open Access   (Followers: 5)
Beitr?ge zur Tabakforschung International/Contributions to Tobacco Research     Open Access   (Followers: 3)
Bio-Algorithms and Med-Systems     Hybrid Journal   (Followers: 2)
Bio-Research     Full-text available via subscription   (Followers: 4)
Bioactive Materials     Open Access   (Followers: 1)
Biocatalysis and Agricultural Biotechnology     Hybrid Journal   (Followers: 4)
Biocybernetics and Biological Engineering     Full-text available via subscription   (Followers: 5)
Bioethics UPdate     Hybrid Journal   (Followers: 1)
Biofuels     Hybrid Journal   (Followers: 11)
Biofuels Engineering     Open Access   (Followers: 1)
Biological & Pharmaceutical Bulletin     Full-text available via subscription   (Followers: 4)
Biological Cybernetics     Hybrid Journal   (Followers: 10)
Biomarkers and Genomic Medicine     Open Access   (Followers: 3)
Biomaterials Research     Open Access   (Followers: 4)
BioMed Research International     Open Access   (Followers: 4)
Biomédica     Open Access  
Biomedical and Biotechnology Research Journal     Open Access  
Biomedical Engineering Research     Open Access   (Followers: 6)
Biomedical Glasses     Open Access  
Biomedical Reports     Full-text available via subscription  
BioMedicine     Open Access  
Biomedika     Open Access  
Bioprinting     Hybrid Journal   (Followers: 1)
Bioresource Technology Reports     Hybrid Journal   (Followers: 1)
Bioscience, Biotechnology, and Biochemistry     Hybrid Journal   (Followers: 21)
Biosensors Journal     Open Access  
Biosimilars     Open Access   (Followers: 1)
Biosurface and Biotribology     Open Access  
Biotechnic and Histochemistry     Hybrid Journal   (Followers: 1)
BioTechniques : The International Journal of Life Science Methods     Full-text available via subscription   (Followers: 28)
Biotechnologia Acta     Open Access   (Followers: 1)
Biotechnologie, Agronomie, Société et Environnement     Open Access   (Followers: 2)
Biotechnology     Open Access   (Followers: 8)
Biotechnology & Biotechnological Equipment     Open Access   (Followers: 4)
Biotechnology Advances     Hybrid Journal   (Followers: 34)
Biotechnology and Applied Biochemistry     Hybrid Journal   (Followers: 44)
Biotechnology and Bioengineering     Hybrid Journal   (Followers: 160)
Biotechnology and Bioprocess Engineering     Hybrid Journal   (Followers: 6)
Biotechnology and Genetic Engineering Reviews     Hybrid Journal   (Followers: 13)
Biotechnology and Health Sciences     Open Access   (Followers: 1)
Biotechnology and Molecular Biology Reviews     Open Access   (Followers: 2)
Biotechnology Annual Review     Full-text available via subscription   (Followers: 5)
Biotechnology for Biofuels     Open Access   (Followers: 10)
Biotechnology Frontier     Open Access   (Followers: 2)
Biotechnology Journal     Hybrid Journal   (Followers: 17)
Biotechnology Law Report     Hybrid Journal   (Followers: 4)
Biotechnology Letters     Hybrid Journal   (Followers: 34)
Biotechnology Progress     Hybrid Journal   (Followers: 41)
Biotechnology Reports     Open Access  
Biotechnology Research International     Open Access   (Followers: 1)
Biotechnology Techniques     Hybrid Journal   (Followers: 10)
Biotecnología Aplicada     Open Access  
Bioteknologi (Biotechnological Studies)     Open Access  
BIOTIK : Jurnal Ilmiah Biologi Teknologi dan Kependidikan     Open Access  
Biotribology     Hybrid Journal   (Followers: 1)
BMC Biotechnology     Open Access   (Followers: 17)
Cell Biology and Development     Open Access  
Chinese Journal of Agricultural Biotechnology     Full-text available via subscription   (Followers: 4)
Communications in Mathematical Biology and Neuroscience     Open Access  
Computational and Structural Biotechnology Journal     Open Access   (Followers: 2)
Computer Methods and Programs in Biomedicine     Hybrid Journal   (Followers: 8)
Copernican Letters     Open Access   (Followers: 1)
Critical Reviews in Biotechnology     Hybrid Journal   (Followers: 20)
Crop Breeding and Applied Biotechnology     Open Access   (Followers: 3)
Current Bionanotechnology     Hybrid Journal  
Current Biotechnology     Hybrid Journal   (Followers: 4)
Current Opinion in Biomedical Engineering     Hybrid Journal   (Followers: 1)
Current Opinion in Biotechnology     Hybrid Journal   (Followers: 55)
Current Pharmaceutical Biotechnology     Hybrid Journal   (Followers: 9)
Current Research in Bioinformatics     Open Access   (Followers: 13)
Current Trends in Biotechnology and Chemical Research     Open Access   (Followers: 3)
Current trends in Biotechnology and Pharmacy     Open Access   (Followers: 8)
DNA and RNA Nanotechnology     Open Access  
EBioMedicine     Open Access  
Electronic Journal of Biotechnology     Open Access  
Entomologia Generalis     Full-text available via subscription   (Followers: 1)
Environmental Science : Processes & Impacts     Full-text available via subscription   (Followers: 4)
Experimental Biology and Medicine     Hybrid Journal   (Followers: 3)
Folia Medica Indonesiana     Open Access  
Food Bioscience     Hybrid Journal  
Food Biotechnology     Hybrid Journal   (Followers: 9)
Food Science and Biotechnology     Hybrid Journal   (Followers: 8)
Frontiers in Bioengineering and Biotechnology     Open Access   (Followers: 6)
Frontiers in Systems Biology     Open Access   (Followers: 2)
Fungal Biology and Biotechnology     Open Access   (Followers: 2)
GM Crops and Food: Biotechnology in Agriculture and the Food Chain     Full-text available via subscription   (Followers: 1)
GSTF Journal of BioSciences     Open Access  
HAYATI Journal of Biosciences     Open Access  
Horticultural Biotechnology Research     Open Access  
Horticulture, Environment, and Biotechnology     Hybrid Journal   (Followers: 11)
IEEE Transactions on Molecular, Biological and Multi-Scale Communications     Hybrid Journal   (Followers: 1)
IET Nanobiotechnology     Hybrid Journal   (Followers: 2)
IN VIVO     Full-text available via subscription   (Followers: 4)
Indian Journal of Biotechnology (IJBT)     Open Access   (Followers: 2)
Indonesia Journal of Biomedical Science     Open Access   (Followers: 2)
Indonesian Journal of Biotechnology     Open Access   (Followers: 1)
Indonesian Journal of Medicine     Open Access  
Industrial Biotechnology     Hybrid Journal   (Followers: 18)
International Biomechanics     Open Access  
International Journal of Bioinformatics Research and Applications     Hybrid Journal   (Followers: 14)
International Journal of Biomechatronics and Biomedical Robotics     Hybrid Journal   (Followers: 4)
International Journal of Biomedical Research     Open Access   (Followers: 2)
International Journal of Biotechnology     Hybrid Journal   (Followers: 5)
International Journal of Biotechnology and Molecular Biology Research     Open Access   (Followers: 4)
International Journal of Biotechnology for Wellness Industries     Partially Free   (Followers: 1)
International Journal of Environment, Agriculture and Biotechnology     Open Access   (Followers: 5)
International Journal of Functional Informatics and Personalised Medicine     Hybrid Journal   (Followers: 4)
International Journal of Medicine and Biomedical Research     Open Access   (Followers: 1)
International Journal of Nanotechnology and Molecular Computation     Full-text available via subscription   (Followers: 3)
International Journal of Radiation Biology     Hybrid Journal   (Followers: 4)
Iranian Journal of Biotechnology     Open Access  
ISABB Journal of Biotechnology and Bioinformatics     Open Access  
Italian Journal of Food Science     Open Access   (Followers: 1)
JMIR Biomedical Engineering     Open Access  
Journal of Biometrics & Biostatistics     Open Access   (Followers: 3)
Journal of Bioterrorism & Biodefense     Open Access   (Followers: 6)
Journal of Petroleum & Environmental Biotechnology     Open Access   (Followers: 1)
Journal of Advanced Therapies and Medical Innovation Sciences     Open Access  
Journal of Advances in Biotechnology     Open Access   (Followers: 5)
Journal Of Agrobiotechnology     Open Access  
Journal of Analytical & Bioanalytical Techniques     Open Access   (Followers: 7)
Journal of Animal Science and Biotechnology     Open Access   (Followers: 4)
Journal of Applied Biomedicine     Open Access   (Followers: 2)
Journal of Applied Biotechnology     Open Access   (Followers: 2)
Journal of Applied Biotechnology Reports     Open Access   (Followers: 2)
Journal of Applied Mathematics & Bioinformatics     Open Access   (Followers: 5)
Journal of Biologically Active Products from Nature     Hybrid Journal   (Followers: 1)
Journal of Biomaterials and Nanobiotechnology     Open Access   (Followers: 6)
Journal of Biomedical Photonics & Engineering     Open Access  
Journal of Biomedical Practitioners     Open Access  
Journal of Bioprocess Engineering and Biorefinery     Full-text available via subscription  
Journal of Bioprocessing & Biotechniques     Open Access  
Journal of BioScience and Biotechnology     Open Access  
Journal of Biosecurity Biosafety and Biodefense Law     Hybrid Journal   (Followers: 3)
Journal of Biotechnology     Hybrid Journal   (Followers: 63)
Journal of Biotechnology and Strategic Health Research     Open Access   (Followers: 1)
Journal of Chemical and Biological Interfaces     Full-text available via subscription   (Followers: 1)
Journal of Chemical Technology & Biotechnology     Hybrid Journal   (Followers: 9)
Journal of Chitin and Chitosan Science     Full-text available via subscription   (Followers: 1)
Journal of Colloid Science and Biotechnology     Full-text available via subscription  
Journal of Commercial Biotechnology     Full-text available via subscription   (Followers: 6)
Journal of Crop Science and Biotechnology     Hybrid Journal   (Followers: 3)
Journal of Ecobiotechnology     Open Access  
Journal of Essential Oil Research     Hybrid Journal   (Followers: 2)
Journal of Experimental Biology     Full-text available via subscription   (Followers: 25)
Journal of Genetic Engineering and Biotechnology     Open Access   (Followers: 5)
Journal of Ginseng Research     Open Access  
Journal of Industrial Microbiology and Biotechnology     Hybrid Journal   (Followers: 18)
Journal of Integrative Bioinformatics     Open Access  
Journal of Medical Imaging and Health Informatics     Full-text available via subscription  
Journal of Molecular Biology and Biotechnology     Open Access  
Journal of Molecular Microbiology and Biotechnology     Full-text available via subscription   (Followers: 13)
Journal of Nano Education     Full-text available via subscription  
Journal of Nanobiotechnology     Open Access   (Followers: 4)
Journal of Nanofluids     Full-text available via subscription   (Followers: 1)
Journal of Organic and Biomolecular Simulations     Open Access  
Journal of Plant Biochemistry and Biotechnology     Hybrid Journal   (Followers: 4)
Journal of Science and Applications : Biomedicine     Open Access  
Journal of the Mechanical Behavior of Biomedical Materials     Hybrid Journal   (Followers: 13)
Journal of Trace Elements in Medicine and Biology     Hybrid Journal   (Followers: 1)
Journal of Tropical Microbiology and Biotechnology     Full-text available via subscription  
Journal of Yeast and Fungal Research     Open Access   (Followers: 1)
Marine Biotechnology     Hybrid Journal   (Followers: 4)
Meat Technology     Open Access  
Messenger     Full-text available via subscription  
Metabolic Engineering Communications     Open Access   (Followers: 4)
Metalloproteinases In Medicine     Open Access  
Microbial Biotechnology     Open Access   (Followers: 10)
MicroMedicine     Open Access   (Followers: 3)
Molecular and Cellular Biomedical Sciences     Open Access   (Followers: 1)
Molecular Biotechnology     Hybrid Journal   (Followers: 13)
Molecular Genetics and Metabolism Reports     Open Access   (Followers: 3)
Nanobiomedicine     Open Access  
Nanobiotechnology     Hybrid Journal   (Followers: 2)

        1 2 | Last

Journal Cover
IET Nanobiotechnology
Journal Prestige (SJR): 0.424
Citation Impact (citeScore): 2
Number of Followers: 2  
 
  Hybrid Journal Hybrid journal (It can contain Open Access articles)
ISSN (Print) 1751-8741 - ISSN (Online) 1751-875X
Published by IET Homepage  [39 journals]
  • Green synthesised iron and iron-based nanoparticle in environmental and
           biomedical application: – a review
    • Authors: Sathya Karunakaran;Saravanathamizhan Ramanujam;Baskar Gurunathan;
      Pages: 1003 - 1008
      Abstract: Owing to the development of nanotechnology and its influence in various fields, the development of efficient and environmental friendly technique for the synthesis of nanomaterials is important. Among the various traditional and conventional methods available for the synthesis, plant-mediated synthesis seems to be a very attractive and environmental friendly method, attributing to its simple methodology and eco-friendly approach. The synthesis rate and stability of the nanoparticle synthesised are good when compared to the other methods of synthesis and it is proved to be efficient in various fields of application. Hence, the present review article deals with furnishing information about the plant sources used so far and details about the environmental and biomedical applications of the synthesised nanoparticles.
      PubDate: 12 2018
      Issue No: Vol. 12, No. 8 (2018)
       
  • Nanomedicine for anticancer and antimicrobial treatment: an overview
    • Authors: Shatavari Kulshrestha;Asad U. Khan;
      Pages: 1009 - 1017
      Abstract: Nanoparticle-based treatment has become a potential therapeutic approach. The nanosize of these particles provides them with unique physicochemical properties and enhances their interaction with the biological system. Nanomaterials have the potential to overcome some of the major issues in the clinical world which may include cancer treatment and may be utilised to resolve the major problem of drug resistance in infection control. These particles are being used to improve present therapeutics by virtue of their shape, size and diverse intrinsic as well as chemical properties. The authors have discussed the use of nanoparticles in cancer treatment, infections caused by multidrug-resistant microbial strains and biofilm inhibition along with the detailed description of the current status of nanomaterials in the field of medicine.
      PubDate: 12 2018
      Issue No: Vol. 12, No. 8 (2018)
       
  • Nigella sativa oil entrapped polycaprolactone nanoparticles for
           leishmaniasis treatment
    • Authors: Emrah Sefik Abamor;Ozlem Ayse Tosyali;Melahat Bagirova;Adil Allahverdiyev;
      Pages: 1018 - 1026
      Abstract: This study is the first to investigate the antileishmanial activities of Nigella sativa oil (NSO) entrapped poly-ε-caprolactone (PCL) nanoparticles on Leishmania infantum promastigotes and amastigotes in vitro. NSO molecules with variable initial doses of 50, 100, 150, and 200 mg were successfully encapsulated into PCL nanoparticles identified as formulations NSO1, NSO2, NSO3, and NSO4, respectively. This process was characterised by scanning electron microscope, dynamic light scattering, Fourier transform infrared, encapsulation efficiency measurements, and release profile evaluations. The resulting synthetised nanoparticles had sizes ranging between 200 and 390 nm. PCL nanoparticles encapsulated 98% to 80% of initial doses of NSO and after incubation released approximately 85% of entrapped oil molecules after 288 h. All investigated formulations demonstrated strong antileishmanial effects on L. infantum promastigotes by inhibiting up to 90% of parasites after 192 h. The tested formulations decreased infection indexes of macrophages in a range between 2.4- and 4.1-fold in contrast to control, thus indicating the strong anti-amastigote activities of NSO encapsulated PCL nanoparticles. Furthermore, NSO-loaded PCL nanoparticles showed immunomodulatory effects by increasing produced nitric oxide amounts within macrophages by 2-3.5-fold in contrast to use of free oil. The obtained data showed significant antileishmanial effects of NSO encapsulated PCL nanoparticles on L. infantum promastigotes and amastigotes.
      PubDate: 12 2018
      Issue No: Vol. 12, No. 8 (2018)
       
  • How nano-wollastonite can change the fundamental properties of a wood
           fibre and rice straw composites'
    • Authors: Ali Hassanpoor Tichi;Ehsan Bari;Darrel D. Nicholas;
      Pages: 1027 - 1030
      Abstract: The potential of using rice straw (RS) in combination with wood fibre in the production of medium density fibreboard was investigated. Nano-wollastonite (NW) was added to some of the panels to determine if it would enhance the physical and mechanical properties. It was found that satisfactory composite boards could be made with the addition of 10% RS to the wood fibre. Furthermore, the mechanical and physical properties of the composite were enhanced when NW was added.
      PubDate: 12 2018
      Issue No: Vol. 12, No. 8 (2018)
       
  • Bio-synthesis of palladium nanocubes and their electrocatalytic properties
    • Authors: Xuwen Peng;Zelin Cui;Xuefeng Bai;Hongfei Lv;
      Pages: 1031 - 1036
      Abstract: The bio-synthesis of palladium nanocubes (PdNCs) was realised using pine needle extract as the reducing agent and cetyl trimethyl ammonium bromide as the capping agent. As an eco-friendly and readily available biomass, pine needle extract avoided the use of highly polluting chemical reducing agents. The growth process of PdNCs was analysed using ultraviolet-vis and Fourier transform infrared spectroscopy. Flavonoids, esters, terpenoids and polyhydric alcohols, which contain reductive groups, were mainly responsible for the transition of Pd2+ ions to PdNCs. The morphology and structure of PdNCs were characterised using transmission electron microscopy (TEM), high-resolution TEM, selected area electron diffraction and X-ray diffraction. It was indicated that the as-prepared PdNCs displayed a relatively high purity and good crystallinity with a face-centred cubic structure and exhibited sizes ranging from 6.11 to 29.51 nm with an average particle size of 11.18 nm. In the methanol electro-oxidation reaction, the PdNCs enclosed by {100} facets exhibited superior electro-catalytic activity to commercial Pd/C, which was rarely reported in other bio-synthesis processes for Pd catalysts. Meanwhile, the PdNCs showed excellent anti-poisoning ability and long-term stability. This study reveals the possibility of preparing shape-controlled PdNCs with a specific structure and excellent electro-catalytic activity.
      PubDate: 12 2018
      Issue No: Vol. 12, No. 8 (2018)
       
  • DOC-LS, a new liposome for dermal delivery, and its endocytosis by HaCaT
           and CCC-ESF-1 cells
    • Authors: Yong-Tai Zhang;Kai Zhang;Zhe Li;Hong-Yu Zhang;Teng Guo;Yan-Yan Li;Ji-Hui Zhao;Nian-Ping Feng;
      Pages: 1037 - 1041
      Abstract: The main objective of this work was to investigate the uptake channels of skin cells through which coumarin 6, transported by deoxycholate-mediated liposomes (DOC-LS), was internalised; this was also compared against the action of conventional LS. Coumarin 6-loaded DOC-LS and LS were characterised for size distribution, zeta potential, and shape, and analysed in vitro in human epidermal immortal keratinocyte (HaCaT) (epidermal) and human embryonic skin fibroblast (CCC-ESF-1) (dermal) cell lines. Various endocytosis inhibitors were incubated with cells treated with the nanocarriers. Flow cytometry results indicated that HaCaT and CCC-ESF-1 cells internalise the tested preparations through pinocytotic vesicles, macropinocytosis, clathrin-mediated endocytic pathways, and via lysosomes, which consume a considerable amount of energy. The endocytosis pathways of DOC-LS and LS showed no difference. This study provides a basis for the application of LS being combined with a microneedle system for efficient intracellular drug delivery, targeting cutaneous histocyte disorders.
      PubDate: 12 2018
      Issue No: Vol. 12, No. 8 (2018)
       
  • Green synthesis of copper oxide nanoparticles and mosquito larvicidal
           activity against dengue, zika and chikungunya causing vector Aedes aegypti
           
    • Authors: Sekaran Muthamil Selvan;Kabali Vijai Anand;Kasivelu Govindaraju;Selvaraj Tamilselvan;Vijayakumar Ganesh Kumar;Kizhaeral Sevathapandian Subramanian;Malaisamy Kannan;Kalimuthu Raja;
      Pages: 1042 - 1046
      Abstract: In the present study, high purity copper oxide nanoparticles (NPs) were synthesised using Tridax procumbens leaf extract. Green syntheses of nano-mosquitocides rely on plant compounds as reducing and stabilising agents. Copper oxide NPs were characterised using X-ray diffraction (XRD) analysis, Fourier transform infrared (FT-IR), Field-emission scanning electron microscopy with energy dispersive spectroscopy, Ultraviolet-visible spectrophotometry and fluorescence spectroscopy. XRD studies of the NPs indicate crystalline nature which was perfectly matching with a monoclinic structure of bulk CuO with an average crystallite size of 16 nm. Formation of copper oxide NPs was confirmed by FT-IR studies and photoluminescence spectra with emission peaks at 331, 411 and 433 nm were assigned to a near-band-edge emission band of CuO in the UV, violet and blue region. Gas chromatography-mass spectrometry studies inferred the phytochemical constituents of the leaf extract. Larvicidal activity of synthesised NPs using T. procumbens leaf extract was tested against Aedes aegypti species (dengue, chikungunya, zika and yellow fever transmit vector).
      PubDate: 12 2018
      Issue No: Vol. 12, No. 8 (2018)
       
  • Biogenic synthesis of biopolymer-based Ag–Au bimetallic nanoparticle
           constructs and their anti-proliferative assessment
    • Authors: Kalaignana Selvi Subbiah;Sashidhar Rao Beedu;
      Pages: 1047 - 1055
      Abstract: This study reports an eco-friendly-based method for the preparation of biopolymer Ag-Au nanoparticles (NPs) by using gum kondagogu (GK; Cochlospermum gossypium), as both reducing and protecting agent. The formation of GK-(Ag-Au) NPs was confirmed by UV-absorption, fourier transformed infrared (FTIR), atomic force microscopy (AFM), scanning electron microscope (SEM) and transmission electron microscope (TEM). The GK-(Ag-Au) NPs were of 1-12 nm in size. The anti-proliferative activity of nanoparticle constructs was assessed by MTT assay, confocal microscopy, flow cytometry and quantitative real-time polymerase chain reaction (PCR) techniques. Expression studies revealed up-regulation of p53, caspase-3, caspase-9, peroxisome proliferator-activated receptors (PPAR) PPARa and PPARb, genes and down-regulation of Bcl-2 and Bcl-x(K) genes, in B16F10 cells treated with GK-(Ag-Au) NPs confirming the anti-proliferative properties of the nanoparticles.
      PubDate: 12 2018
      Issue No: Vol. 12, No. 8 (2018)
       
  • Ferulic acid encapsulated chitosan-tripolyphosphate nanoparticles
           attenuate quorum sensing regulated virulence and biofilm formation in
           Pseudomonas aeruginosa PAO1
    • Authors: Subhaswaraj Pattnaik;Subhashree Barik;Gangatharan Muralitharan;Siddhardha Busi;
      Pages: 1056 - 1061
      Abstract: Pseudomonas aeruginosa is an opportunistic nosocomial pathogenic microorganism causing majority of acute hospital-acquired infections and poses a serious public health concern. The persistence of bacterial infection can be attributed to the highly synchronised cell-to-cell communication phenomenon, quorum sensing (QS) which regulates the expression of a number of virulence factors and biofilm formation which eventually imparts resistance to the conventional antimicrobial therapy. In this study, the anti-quorum sensing and anti-biofilm potential of ferulic acid encapsulated chitosan-tripolyphosphate nanoparticles (FANPs) was investigated against P. aeruginosa PAO1 and compared with native ferulic acid. Dynamic light scattering and transmission electron microscopic analysis confirmed the synthesis of FANPs with mean diameter of 215.55 nm. FANPs showed significant anti-quorum sensing activity by downregulating QS-regulated virulence factors. In addition, FANPs also significantly attenuate the swimming and swarming motility of P. aeruginosa PAO1. The anti-biofilm efficacy of FANPs as compared to native ferulic acid was established by light and confocal laser scanning microscopic analysis. The promising results of FANPs in attenuating QS highlighted the slow and sustained release of ferulic acid at the target sites with greater efficacy suggesting its application towards the development of anti-infective agents.
      PubDate: 12 2018
      Issue No: Vol. 12, No. 8 (2018)
       
  • Investigative evaluation of Cassia absus for antibacterial capacity and
           biomimetic synthesis of silver nanoparticles
    • Authors: Mehreen Jehan;Fiza Saeed;Zanib Khan;Muddassar Shah;Ayesha Sikandar;Afia Inayat;Sartaj Ali;Arshad Mehmood Khan;Ayesha Talib;Muhammad Aasim;Abid Ali Khan;
      Pages: 1062 - 1066
      Abstract: Cassia absus is used for medicinal purposes for a long time all over the world. In this study, the authors report the antimicrobial potential of C. absus extracts obtained with different solvents. The extract(s) obtained with ethyl acetate yielded the best antibacterial effects because of a rich supply of oxalates and alkaloids in it. The same extract was also exploited for reducing Ag+ ions (to metallic Ag0) for the synthesis of nanoparticles. Electron microscopy revealed that the silver nanoparticles were ~18-25 nm in diameter. The Fourier-transform infrared evaluation pointed towards the fact that flavonoids present in the plant extract were acting as reductants while amino groups were the bound stabilisation agents to the synthesised nanoparticles limiting the diameter to a certain threshold and avoiding aggregation naturally. A comparative antibacterial assay of C. absus versus Ag nanoparticles showed that the nanoparticles as well as organic (ethyl acetate) extract of the plant checked the growth of selected (MDR) superbugs. However, the biosynthesised Ag nanoparticles returned better antibacterial efficacies than ethyl acetate extract.
      PubDate: 12 2018
      Issue No: Vol. 12, No. 8 (2018)
       
  • Comparative antileishmanial efficacy of the biosynthesised ZnO NPs from
           genus Verbena
    • Authors: Sumaira;Muhammad Siddique Afridi;Syed Salman Hashmi;Gul Shad Ali;Muhammad Zia;Bilal Haider Abbasi;
      Pages: 1067 - 1073
      Abstract: This study describes ZnO NPs biosynthesis using leaf extracts of Verbena officinalis and Verbena tenuisecta. The extracts serve as natural reducing, capping and stabilization facilitators. Plant extracts phytochemical analysis, revealed that V. officinalis showed higher total phenolic and flavonoid content (22.12 and 6.38 mg g -1 DW) as compared to V. tennuisecta (12.18 and 2.7 mg g -1 DW). ZnO NPs were characterised by ultraviolet-visible spectroscopy, Fourier transform infrared, X-ray diffraction, scanning electron microscope, transmission electron microscopy (TEM) and energy dispersive X-ray. TEM analysis of ZnO NPs reveals rod and flower shapes and were in the range of 65-75 and 14-31 nm, for V. tenuisecta and V. officinalis, respectively. Bio-potential of ZnO NPs was examined through their leishmanicidal potential against Leishmania tropica. ZnO NPs showed potent leishmanicidal activity with 250 μg ml-1 being the most potent concentration. V. officinalis mediated ZnO NPs showed more potent leishmanicidal activity compared to V. tenuisecta mediated ZnO NPs due to their smaller size and increased phenolics doped onto its surface. These results can be a step forward towards the development of novel compounds that can efficiently replace the current medication schemes for leishmaniasis treatment.
      PubDate: 12 2018
      Issue No: Vol. 12, No. 8 (2018)
       
  • Design and fabrication of drug-eluting polymeric thin films for
           applications in ophthalmology
    • Authors: Lampros Lamprogiannis;Athanasios Karamitsos;Varvara Karagkiozaki;Ioannis Tsinopoulos;Maria Gioti;Dimitrios G. Fatouros;Stavros Dimitrakos;Stergios Logothetidis;
      Pages: 1074 - 1079
      Abstract: To study the development, characterisation, and drug release of one- and two-layered thin films based on organic polymers [poly(D,L-lactide-co-glycolide) lactide:glycolide (65:35), poly(D,L-lactide-co-glycolide) lactide:glycolide (75:25), and polycaprolactone] and dexamethasone. To examine their applicability for intraocular lenses (IOLs) and function in intraocular drug delivery systems. Four series of thin films, single and double-layer, were prepared by the spin-coating method on a silicon substrate. The films were studied using atomic force microscopy and spectroscopic ellipsometry. The release rate of dexamethasone was studied for a period of ten weeks. Series A and C demonstrated the formation of large dexamethasone aggregates. The monolayer films of series C and D formed pores, in agreement with previous findings. The spectroscopic ellipsometry study demonstrated that the samples were transparent. The drug release study demonstrated that dexamethasone was released during the first 6 weeks at a desirable rate. The films exhibited properties suitable for use in intraocular drug delivery systems. The single-layer thin films demonstrated a sufficient encapsulation of dexamethasone and appropriate release of the therapeutic substance. Further studies are necessary to investigate the possibility of developing the films directly on the surface of the IOL.
      PubDate: 12 2018
      Issue No: Vol. 12, No. 8 (2018)
       
  • High thermal stability and low power dissipation PCM with nanoscale
           oxygen-doped SS thin film
    • Authors: Haipeng You;Yifeng Hu;Tianshu Lai;Qingqian Chou;Xiaoqin Zhu;Hua Zou;
      Pages: 1080 - 1083
      Abstract: To improve thermal stability and reduce power dissipation of phase-change memory (PCM), the oxygen-doped Sn15Sb85 (SS) thin film is proposed by magnetron sputtering in this study. Comparing to undoped Sn15Sb85(SS), the oxygen-doped-SS thin film has superior thermal stability and better data retention. Meanwhile, the electrical conductivity of crystallisation oxygen-doped-SS thin film is also lower than that of SS, which means its less power consuming in PCM. The electrical conductivity ratio between amorphous and crystalline states for oxygen-doped SS reaches up to two orders of magnitude. After oxygen doping, the root-mean-square surface roughness from amorphous (0.29 nm) to crystalline (0.46 nm) state for oxygen-doped-SS thin films becomes smaller. The switching time of amorphisation process for the oxygen-doped-SS thin film (~2.07 ns) is shorter than Ge2Sb2Te5 (GST) (~3.05 ns). X-ray diffractometer is recorded to investigate the change of crystalline structure. Thus, the authors infer that oxygen-doped SS is a promising phase-change thin film for PCM.
      PubDate: 12 2018
      Issue No: Vol. 12, No. 8 (2018)
       
  • Biogenically engineered nanoparticles inhibit Fusarium oxysporum causing
           soft-rot of ginger
    • Authors: Vaibhavi Athawale;Priti Paralikar;Avinash P. Ingle;Mahendra Rai;
      Pages: 1084 - 1089
      Abstract: Soft-rot of ginger (Zingiber officinale) is the most important disease usually caused by Fusarium oxysporum (F. oxysporum) leading to significant yield loss. In this study, chitosan, copper and sulphur nanoparticles synthesised from leaf extract of selected plants were screened against two isolates of F. oxysporum recovered from the infected rhizome of ginger and soil samples. Moreover, among these, sulphur nanoparticles showed maximum inhibition of F. oxysporum isolated from soil samples (ZOI = 12.33 mm) followed by copper (ZOI = >12 mm) and chitosan nanoparticles (ZOI = >9 mm). Similarly, in the case of F. oxysporum isolated from infected ginger, sulphur nanoparticles showed maximum inhibition (ZOI = 13.33) as compared to copper (ZOI = >11 mm) and chitosan nanoparticles (ZOI = >9 mm). Considering the high efficacy, sulphur nanoparticles were further evaluated in combination with commercial fungicides, viz., bavistin, ridomil gold, sunflex and streptocycline. The combination of sulphur nanoparticles with bavistin demonstrated maximum inhibition (ZOI = 45.16 mm, MIC -20 μg/ml), whereas the minimum inhibition was shown by its combination with ridomil gold (ZOI = 10.5 mm, MIC -40 μg/ml). Therefore, it can be concluded that the combination of sulphur nanoparticles with bavistin can be used for effective and eco-friendly management of F. oxysporum causing soft-rot of ginger.
      PubDate: 12 2018
      Issue No: Vol. 12, No. 8 (2018)
       
  • Removal of toxic contaminants from water by sustainable green synthesised
           non-toxic silver nanoparticles
    • Authors: Nafeesa Khatoon;Hammad Alam;Nikhat Manzoor;Meryam Sardar;
      Pages: 1090 - 1096
      Abstract: The study describes the synthesis of silver nanoparticles using 21 different plant extracts having medicinal properties. Molecular ultraviolet-visible spectroscopy shows that the λmax of nanoparticles synthesised by different plant extracts varied and ranged between 400 and 468 nm. The ultraviolet results revealed that although synthesis of nanoparticles occurred by all plant extracts successfully, their size varies, this was further confirmed by differential light scattering. The synthesised nanoparticles were investigated for their antimicrobial properties. The most promising silver nanoparticles Ocimum sanctum and Artemisia annua assisted were further characterised using transmission electron microscopy and energy dispersive X-ray spectroscopy (EDX). EDX data confirms that synthesised nanoparticles are highly pure. Further these two plant assisted nanoparticles were studied for chemocatalytic and adsorptive properties. The silver nanoparticles from Ocimum sanctum can catalyse the reduction of 4-nitrophenol (63%) within 20 min in the presence of NaBH4, whereas Artemisia annua assisted silver nanoparticles did not show significant chemocatalytic activity. Both the promising nanoparticles can efficiently adsorb textile dyes from aqueous solutions. These synthesised nanoparticles were also exploited to remove microbial and other contaminants from Yamuna River water. The nanoparticles show excellent antimicrobial properties and can be reused repeatedly.
      PubDate: 12 2018
      Issue No: Vol. 12, No. 8 (2018)
       
  • Ketoconazole-conjugated ZnO nanoparticles based semi-solid formulation and
           study their impacts on skin disease
    • Authors: Kaliyaperumal Viswanathan;Rajasekar vaiyamalai;Diviya Bharathi babu;Murugaiyan Latha Mala Priyadharshini;Muthusamy Raman;Gopal Dhinakarraj;
      Pages: 1097 - 1101
      Abstract: In this study, the ketoconazole-conjugated zinc oxide (ZnO) nanoparticles were prepared in a single-step approach using dextrose as an intermediate compound. The physical parameters confirmed the drug conjugation with ZnO and their size was around 70-75 nm. The drug loading and in vivo drug release studies indicated that the -CHO group from the dextrose increase the drug loading up to 65% and their release kinetics were also studied. The anti-fungal studies indicated that the prepared nanoparticles exhibit strong anti-fungal activity and the minimum concentration needed is 10 mg/ml. The nanoparticles loaded semi-solid gel was prepared using carbopol, methylparaben, propyl paraben and propylene glycol. The in vitro penetration of the ketoconazole-conjugated nanoparticles was studied using the skin. The results indicated that the semi-solid gel preparations influenced the penetration and also favoured the accumulation into the skin membrane. The veterinary clinical studies indicated that the prepared gel is highly suitable for treatment of Malassezia.
      PubDate: 12 2018
      Issue No: Vol. 12, No. 8 (2018)
       
  • Comparative study of antifungal effect of green and chemically synthesised
           silver nanoparticles in combination with carbendazim, mancozeb, and thiram
           
    • Authors: Pragati Jamdagni;J.S. Rana;Poonam Khatri;
      Pages: 1102 - 1107
      Abstract: This study reports synthesis and characterisation of silver nanoparticles and their effect on antifungal efficacy of common agricultural fungicides. Silver nanoparticles were synthesised using biological and chemical reduction methods employing Elettaria cardamomum leaf extract and sodium citrate, respectively. Nanoparticles were then characterised using UV-Visible spectroscopy, X-ray diffraction (XRD), transmission electron microscopy, and dynamic light scattering (DLS). While XRD assigned particles size of 31.86 nm for green and 41.91 nm for chemical silver nanoparticles with the help of the Debye-Scherrer formula, DLS specified monodisperse nature of both suspensions. Nanoparticles were tested individually and in combination with fungicides (carbendazim, mancozeb, and thiram) against fungal phytopathogens. Silver nanoparticles exhibited good antifungal activity and minimum inhibitory concentration (MIC) was observed in the range of 8-64 μg/ml. Also, they positively influenced the efficacy of fungicides. The mean MIC value (mean ± SD) for combination of all three fungicides with green AgNPs was 1.37 ± 0.6 μg/ml and for chemical AgNPs was 1.73 ± 1.0 μg/ml. Hence, it could be concluded that green AgNPs performed better than chemical AgNPs. Synergy was observed between green AgNPs and fungicides against Fusarium oxysporum. In conclusion, this study reports synthesis of monodisperse silver nanoparticles which serve as efficient antifungal agents and also enhance the fungicidal action of reported agricultural fungicides in combination studies.
      PubDate: 12 2018
      Issue No: Vol. 12, No. 8 (2018)
       
  • Biocompatible biodegradable polycaprolactone/basil seed mucilage scaffold
           for cell culture
    • Authors: Ali Reza Allafchian;Seyed Amir Hossein Jalali;Seyed Ebrahim Mousavi;
      Pages: 1108 - 1113
      Abstract: In this study, a polymer obtained from the basil seed mucilage (BSM) in combination with polycaprolactone (PCL), was used in the 2D scaffold production process for cell culture. First, combinations of two polymers with different ratios and concentrations were prepared and electrospun. Among these samples, a sample with a BSM/PCL ratio of 2/3 was used to perform different tests due to its fibre uniformity and appropriate diameter. The Fourier transform infrared spectrometer test was carried out to chemically analyse the scaffold, the X-ray diffraction test to determine the crystallinity of the scaffold, and the contact angle test to determine the hydrophilicity of the scaffold. The strength, porosity, and degradation percentage of the scaffold were also studied. With appropriate conditions of the scaffold for cell culture determined, Vero epithelial cells were cultured on the scaffold. Results obtained from cell culture indicated that the adhesion of the scaffold was suitable for the appropriate growth cells.
      PubDate: 12 2018
      Issue No: Vol. 12, No. 8 (2018)
       
  • Evaluation of antimicrobial activity of synthesised silver nanoparticles
           using Thymus kotschyanus aqueous extract
    • Authors: Maryam Gholami;Kiana Shahzamani;Abdolrazagh Marzban;Hamed Esmaeil Lashgarian;
      Pages: 1114 - 1117
      Abstract: Development of a green chemistry process for the synthesis of silver nanoparticles (AgNPs) has become a focus of interest. Characteristics of AgNPs were determined using techniques, such as ultraviolet-visible spectroscopy (UV-vis), Fourier transform infrared (FTIR) analysis, scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy and X-ray diffraction (XRD). The synthesised AgNPs using Thymus kotschyanus had the most growth inhibition against gram-positive bacteria such as Staphylococcus aureus and Bacillus subtilise, while the growth inhibition of AgNPs at 1000-500 μg/ml occurred against Klebsiella pneumonia and at 1000-250 μg/ml of AgNPs was observed against E. coli. The UV-vis absorption spectra confirmed the formation of the AgNPs with the characteristic peak at 415 nm and SEM micrograph acknowledged spherical particles in a nanosize range. FTIR measured the possible biomolecules that are responsible for stabilisation of AgNPs. XRD analysis exhibited the crystalline nature of AgNPs and showed face-centred cubic structure. The synthesised AgNPs revealed significant antibacterial activity against gram-positive bacteria.
      PubDate: 12 2018
      Issue No: Vol. 12, No. 8 (2018)
       
  • Evaluation of ‘green’ synthesis and biological activity of gold
           nanoparticles using Tragopogon dubius leaf extract as an antibacterial
           agent
    • Authors: Somayeh Layeghi-Ghalehsoukhteh;Jafar Jalaei;Mehdi Fazeli;Parastoo Memarian;Seyed Shahram Shekarforoush;
      Pages: 1118 - 1124
      Abstract: Currently, the use of `green' synthesised nanoparticles with environmentally friendly properties is considered a novel therapeutic approach in medicine. Here, the authors evaluated gold nanoparticles (AuNPs) conjugated with Tragopogon dubius leaf extract and their antibacterial activity in vitro and in vivo. Colour changes from yellow to dark brown and a peak at 560 nm on ultraviolet-visible spectroscopy confirmed the formation of nanoparticles. Additionally, transmission electron microscopy, X-ray diffraction, and Fourier transform infrared spectroscopy analyses were performed to determine particle sizes and functional groups involved in gold reduction. Moreover, using standard micro-dilution and disc-diffusion assays against Klebsiella pneumoniae, Bacillus cereus, Escherichia coli, and Staphylococcus aureus, the antimicrobial properties of synthesised AuNPs were investigated. To confirm antibacterial activity, synthesised AuNPs were applied in a rat model on burn wounds infected with S. aureus, and the nanoparticles were as effective as tetracycline in bacterial reduction and wound healing. In conclusion, the synthesis of AuNPs with aqueous T. dubius extract was rapid, simple, and inexpensive, and the synthesised nanoparticles had significant antibacterial activity in vitro and in vivo.
      PubDate: 12 2018
      Issue No: Vol. 12, No. 8 (2018)
       
  • Experimental and theoretical investigation of sensing parameters in carbon
           nanotube-based DNA sensor
    • Authors: Mina Nouri;Bahar Meshginqalam;Milad Moutab Sahihazar;Raziyeh Sheydaie Pour Dizaji;Mohammad Taghi Ahmadi;Razali Ismail;
      Pages: 1125 - 1129
      Abstract: Nowadays, sensitive biosensors with high selectivity, lower costs and short response time are required for detection of DNA. The most preferred materials in DNA sensor designing are nanomaterials such as carbon and Au nanoparticles, because of their very high surface area and biocompatibility which lead to performance and sensitivity improvements in DNA sensors. Carbon nanomaterials such as carbon nanotubes (CNTs) can be considered as a suitable DNA sensor platform due to their high surface-to-volume ratio, favourable electronic properties and fast electron transfer rate. Therefore, in this study, the CNTs which are synthesised by pulsed AC arc discharge method on a high-density polyethylene substrate are used as conducting channels in a chemiresistor for the electrochemical detection of double stranded DNA. Moreover, the response of the proposed sensor is investigated experimentally and analytically in different temperatures, which confirm good agreement between the presented model and experimental data.
      PubDate: 12 2018
      Issue No: Vol. 12, No. 8 (2018)
       
  • Boolean AND and OR logic for cell signalling gateways: a communication
           perspective
    • Authors: Ankit;Manav R. Bhatnagar;
      Pages: 1130 - 1139
      Abstract: Cell signalling plays a vital role in development, sustaining, differentiation, and reproduction of cells. Pathways involved in signalling networks are quite interwoven and complex. Complexity encountered in understanding these pathways is often reduced with the help of Boolean circuit representation. In this study, the authors provide communication aspect of the signalling pathways that have two input Boolean logic AND/OR implemented at the rear effector protein. Communication is assumed to be taking place in extracellular and intracellular environment. The two environments are connected using a receptor protein acting as relay between a molecular source and effector protein. Each relay detects molecules from outside environment and stimulates the production of signals in the intracellular space. These signals/molecules further activate the effector protein which acts as a Boolean switch driven by AND/OR logic. Assuming Poisson reception at the relay as well as at the receiver, the authors provide probability of error of the AND and OR Boolean logic communication systems. Furthermore, reliability and some capacity bounds are deduced for the given Boolean communication system.
      PubDate: 12 2018
      Issue No: Vol. 12, No. 8 (2018)
       
  • Probe for sensitive direct determination of sulphide ions based on gold
           nanoparticles
    • Authors: Neda Shahbazi;Rouholah Zare-Dorabei;
      Pages: 1140 - 1143
      Abstract: A highly selective and sensitive optical sensor based on localised surface plasmon resonance (LSPR) of gold nanoparticles (AuNPs) for the determination of a sulphide ion in aqueous solution is presented. The existence of sulphide is change the intensity of the LSPR band around 520 nm. In this sensor, sulphide ions were recognised and measured by UV-vis spectrophotometry. Three factors such as pH, time and concentration of AuNPs have been studied. The optimisation of effective parameters is done by one at a time method. This method was simple, rapid and cost efficient for the detection of sulphide. The linear range is 1.00-10.00 (4.16-41.63 μM) ppm with the correlation coefficient of 0.9874 and the detection limit of 0.54 ppm. The relative standard deviation of the reported method is 1.01%.
      PubDate: 12 2018
      Issue No: Vol. 12, No. 8 (2018)
       
  • Cytotoxicity investigations of biogenic tellurium nanorods towards PC12
           cell line
    • Authors: Mojtaba Shakibaie;Azam Abharian;Hamid Forootanfar;Atefeh Ameri;Mandana Jafari;Hamid Reza Rahimi;
      Pages: 1144 - 1149
      Abstract: The authors evaluated the cytotoxicity underlying mechanisms of biogenic tellurium (Te) nanorods (NRs) produced by the Pseudomonas pseudoalcaligenes strain Te on the PC12 cell line. The half-maximal inhibitory concentration (IC50) value was estimated at 5.05 ± 0.07 ng/ml for biogenic Te NRs and 2.44 ± 0.38 ng/ml for K2TeO3, respectively. The viability of PC12 was inhibited concentration dependent at doses of 1, 2.5, 5, 10, and 20 ng/ml. Te NRs principally induced late apoptosis or necrosis at IC50 concentration, without effect on caspase-3 activities. Furthermore, Te NRs reduced glutathione and enhanced malondialdehyde levels, and also reduced superoxide dismutase and catalase activities. These findings revealed that biogenic Te NRs were less toxic than K2TeO3. Additionally, they induced cytotoxity towards the PC12 cell line through the activation of late apoptosis independent of the caspase pathway, and may also enhance oxidative stress in the nervous system.
      PubDate: 12 2018
      Issue No: Vol. 12, No. 8 (2018)
       
 
 
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