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Accounts of Chemical Research     Full-text available via subscription   (Followers: 283)
ACS Combinatorial Science     Full-text available via subscription   (Followers: 9)
Acta Analytica     Hybrid Journal   (Followers: 7)
Advances in Analytical Chemistry     Open Access   (Followers: 20)
American Journal of Analytical Chemistry     Open Access   (Followers: 27)
Analytica Chimica Acta     Hybrid Journal   (Followers: 33)
Analytical and Bioanalytical Chemistry     Hybrid Journal   (Followers: 28)
Analytical Chemistry     Full-text available via subscription   (Followers: 400)
Analytical Chemistry Insights     Open Access   (Followers: 16)
Analytical Letters     Hybrid Journal   (Followers: 10)
Analytical Spectroscopy Library     Full-text available via subscription   (Followers: 10)
Annual Review of Analytical Chemistry     Full-text available via subscription   (Followers: 9)
Biomonitoring     Open Access  
Chinese Journal of Analytical Chemistry     Full-text available via subscription   (Followers: 3)
Combinatorial Chemistry - an Online Journal     Open Access   (Followers: 2)
Comprehensive Analytical Chemistry     Full-text available via subscription   (Followers: 5)
Critical Reviews in Analytical Chemistry     Hybrid Journal   (Followers: 25)
Current Analytical Chemistry     Hybrid Journal   (Followers: 6)
Drug Testing and Analysis     Hybrid Journal   (Followers: 5)
Electroanalysis     Hybrid Journal   (Followers: 5)
Field Analytical Chemistry and Technology     Hybrid Journal   (Followers: 5)
Handbook of Analytical Separations     Full-text available via subscription   (Followers: 1)
Handbook of Thermal Analysis and Calorimetry     Full-text available via subscription  
International Journal of Analytical Chemistry     Open Access   (Followers: 20)
International Journal of Chemical and Analytical Science     Full-text available via subscription   (Followers: 4)
International Journal of Environmental Analytical Chemistry     Hybrid Journal   (Followers: 6)
International Journal of Polymer Analysis and Characterization     Hybrid Journal   (Followers: 5)
Journal of Analytical & Bioanalytical Techniques     Open Access   (Followers: 5)
Journal of Analytical Atomic Spectrometry     Full-text available via subscription   (Followers: 9)
Journal of Analytical Chemistry     Hybrid Journal   (Followers: 16)
Journal of Electroanalytical Chemistry     Hybrid Journal   (Followers: 4)
Journal of Essential Oil Research     Hybrid Journal   (Followers: 3)
Journal of Radioanalytical and Nuclear Chemistry     Hybrid Journal   (Followers: 3)
Journal of Thermal Analysis and Calorimetry     Hybrid Journal   (Followers: 18)
Main Group Metal Chemistry     Full-text available via subscription   (Followers: 1)
Microchemical Journal     Hybrid Journal   (Followers: 3)
Nigerian Journal of Chemical Research     Full-text available via subscription  
Phytochemical Analysis     Hybrid Journal   (Followers: 1)
Polish Journal of Chemical Technology     Open Access   (Followers: 1)
Reviews in Analytical Chemistry     Full-text available via subscription   (Followers: 7)
Sample Preparation     Open Access  
Surface and Interface Analysis     Hybrid Journal   (Followers: 14)
Techniques and Instrumentation in Analytical Chemistry     Full-text available via subscription   (Followers: 6)
TrAC Trends in Analytical Chemistry     Full-text available via subscription   (Followers: 20)
Trends in Environmental Analytical Chemistry     Hybrid Journal   (Followers: 1)
Vibrational Spectroscopy     Hybrid Journal   (Followers: 8)
World Journal of Analytical Chemistry     Open Access  
Journal Cover   Journal of Analytical Chemistry
  [SJR: 0.33]   [H-I: 19]   [18 followers]  Follow
   Hybrid Journal Hybrid journal (It can contain Open Access articles)
   ISSN (Print) 1608-3199 - ISSN (Online) 1061-9348
   Published by Springer-Verlag Homepage  [2302 journals]
  • Resolution of overlapped quaternary spectral bands by net analyte signal
           based methods; an application to different combinations in tablets and
    • Abstract: Abstract Net analyte signal (NAS) based methods (NBMs); namely NAS preprocessing (NAP) and hybrid linear analysis (HLA) were applied as multivariate calibration methods for resolving quaternary spectrally overlapped bands of Chlorzoxazone (CXZ), Paracetamol (PAR), Ibuprofen (IBU) and Ketoprofen (KTO) which are commonly co-formulated. The calibration set was composed of 17 mixtures within the concentrations ranges of 8.80–13.20, 10.56–15.84, 7.04–10.56 and 1.76–2.64 μg/mL for CXZ, PAR, IBU and KTO, respectively. A wavelength selection procedure was presented for the introduced NBMs. Figures of merit as limit of detection, selectivity and analytical sensitivity were also calculated based on the NAS concept. The developed NBMs models used smaller number of wavelengths as well as smaller number of latent variables which make NAP and HLA models more simple and interpretable than the conventional partial least squares (PLS). The models were successfully applied to tablets and capsules, and ANOVA was applied in comparison with an HPLC method.
      PubDate: 2015-04-01
  • Determination of rare-earth elements in nitric acid solutions with high
           concentrations of uranium and macrocomponents
    • Abstract: Abstract Spectral and matrix effects of uranium and other macrocomponents on the determination of rare-earth elements (REE) are studied. The experimental data are updated and verified using a fractional factorial experiment. A procedure is developed for the direct determination of REE in solutions with high concentrations of uranium and fission products (FP) using inductively coupled plasma-atomic emission spectroscopy (ICP-AES).
      PubDate: 2015-04-01
  • Determination of a series of nonsteroidal anti-inflammatory drugs using
           the sensitized luminescence of lanthanides
    • Abstract: Abstract The spectral-luminescent characteristics of a series of nonsteroidal anti-inflammatory drugs (NSAID) and their complexes with Eu(III) and Tb(III) have been studied. A possibility of NSAID determination using the sensitized luminescence of lanthanides has been shown. A synergistic effect of the impact of trioctylphosphine oxide (TOPO) and Triton X-100 on the luminescence intensity of mixed-ligand complexes La(III)-NSAID-TOPO in a micellar medium (Triton X-100), used as analytical forms, has been found. The limits of detection for NSAID in various dosage forms are from 0.012 to 2.0 μg/mL.
      PubDate: 2015-04-01
  • Bifunctional derivatives of β-adrenoreceptor modulators in
           chromatography-mass spectrometry
    • Abstract: Abstract Results of a comparative study of methods of derivatization for the determination of β-blockers and β-agonists by gas chromatography-mass spectrometry have been presented. The efficiency of the best method has been confirmed by an example of a GC-MS analysis of a mixture of 13 β-adrenoreceptor modulators after the preparation of corresponding bifunctional derivatives.
      PubDate: 2015-04-01
  • Solid phase extraction and quantification of diclofenac sodium in human
           plasma by liquid chromatography-tandem mass spectrometry
    • Abstract: Abstract A novel liquid chromatography-tandem mass spectrometry (LC-MS-MS) method is described for the quantitative determination of diclofenac in human K2EDTA plasma in negative ion mode and validated using zidovudine as internal standard (IS). Sample preparation was accomplished by solid phase extraction technique. The eluted samples were chromatographed on Zorbax XDB phenyl column (75 × 4.6 mm, 3.5 μm) Agilent Technologies, using a mobile phase consisting of HPLC grade acetonitrile—0.2% acetic acid in HPLC water (80: 20, v/v).The injection volume was 15 μL and the total run time was 2.0 min. The method was validated over a linear concentration range of 25 to 4004 ng/mL diclofenac. The precursors to product ion transitions m/z 294.10 to 249.90 (diclofenac) and m/z 266.0 to 222.90 (zidovudine, IS) were used for quantitation. The retention times were 1.12 and 0.86 min for diclofenac and zidovudine, respectively. Validation results show that the method is selective and capable of quantifying the analyte with good precision and accuracy. The method is stable for the studied parameters. Therefore, a rapid, sensitive LC-MS-MS method for quantification of diclofenac in human plasma was developed and can be used in therapeutic drug monitoring of this drug.
      PubDate: 2015-04-01
  • Chemical differentiation of silver(I), gold(I), and palladium(II)
           complexes with dipropyl disulfide groups covalently bound to a silica
           surface and Michler’s thioketone in solid-phase spectrophotometry
    • Abstract: Abstract A method is proposed for the adsorption-photometric determination of silver, gold, and palladium from one sample as their mixed-ligand complexes with dipropyl disulfide groups covalently bound to a silica surface and Michler’s thioketone, based on the measurement of the intensity of the adsorbent color, decreasing after treatment with destructive agents. The method is used for the determination of gold and palladium in the copper-nickel sludge.
      PubDate: 2015-04-01
  • Efficiency of a cobalt-containing matrix modifier based on activated
           carbon for the electrothermal atomic absorption determination of the
           highly volatile elements
    • Abstract: Abstract The energies of the chemisorption of As, Se, Pb, and Cd atoms by palladium and cobalt metal surfaces were calculated by a quantum chemistry method. The analytical applicability of a cobalt-containing chemical modifier based on activated carbon to the determination of the highly volatile elements by electrothermal atomic absorption spectrometry (ETAAS) was hypothesized. A procedure for the preparation of the cobalt-containing chemical modifier based on activated carbon was substantiated using thermodynamic simulation, thermal analysis, and ETAAS. This procedure ensured the formation of a Co0 metal phase and the occurrence of thermal stabilizing interactions with analytes at the stage of drying. The concentrations of arsenic and lead in the suspensions of a standard reference sample of marine algae were determined with the use of the developed chemical modifier based on activated carbon. The experimental results were consistent with the certified values.
      PubDate: 2015-04-01
  • Voltammetric techniques at chemically modified electrodes
    • Abstract: Abstract Voltammetric and amperometric techniques are powerful analytical tools that are widely used in chemical analysis. This article reviews a summary of some important types of modifying agents and their application in voltammetric and amperometric sensors for clinically and biologically important target species reported from the period 2003 to 2013. In this review, different modifiers such as molecularly imprinted polymers (MIPs), polymers, metal complexes, nanomaterials and composite films are discussed. Under the heading of each modifier, method of fabrication, properties, and applications of chemically modified electrodes (CMEs) are given. Tables that give analyte, modified electrode, measurement technique, measuring medium, linear detection range (LDR) and limit of detection (LOD) referenced from original work are also provided.
      PubDate: 2015-04-01
  • Potentiometric sensors for the determination of some cephalosporin
           antibiotics in biological fluids and medicinal preparations
    • Abstract: Abstract Potentiometric sensors based on ion associates of Cefalexin, Cefuroxime, and Cefixime with tetraalkylammonium cations are developed. The sensors ensure the determination of cephalosporin antibiotics in a wide analytical range of 1 × 10−4 (1 × 10−5) to 1 × 10−2 (0.1) M; the values of c min, p ∼ n × 10−5 (10−6) M. The sensors can be used for the determination of cephalosporins in biological fluids for the adjustment and optimization of treatment and for determining the main substance in pharmaceuticals.
      PubDate: 2015-04-01
  • Highly sensitive spectrofluorimetric assay of copper(II)
    • Abstract: Abstract A highly sensitive and simple spectrofluorimetric method for the determination of copper(II) based on its fluorescence quenching effect on the hemoglobin-catalyzed reaction of H2O2 with L-tyrosine was developed. The concentration of copper(II) is linear with the fluorescence quenching (ΔF) of system under the optimal experimental conditions. The calibration graph is linear in the range 2.7 to 5.3 × 102 ng/mL with the limit of detection of 2 ng/mL. This method can be used for the determination of copper(II) in foodstuffs and hair with satisfactory results.
      PubDate: 2015-04-01
  • Simultaneous determination of aliskiren, amlodipine and
           hydrochlorothiazide in spiked human plasma and urine by high performance
           liquid chromatography
    • Abstract: Abstract A reversed-phase (RP) liquid chromatographic technique for the simultaneous determination of aliskiren (ALS), amlodipine (AMD) and hydrochlorothiazide (HCT) in spiked human plasma and urine is presented. The method employs a gradient elution using 10 mM orthophosphoric acid containing 0.1% triethylamine (pH 2.5, v/v) and acetonitrile and an RP-C18 column (4.6 mm × 250 mm, 5 μm, Phenomenex) at 1 mL/min of flow rate, with a UV photo diode array detector at 271 nm. The linear ranges were 0.01–10 μg/mL in plasma and 0.05–10 μg/mL in urine for both ALS and AMD. The linearty of HCT was in the range of 0.0125–2.5 μg/mL in plasma and urine. Correlation coefficients (r 2) were higher than 0.9983 for all of the analytes, indicating good linear relationship. The method validation was performed with respect to linearity, recovery, accuracy, precision and stability. The developed method could be applied in the routine clinical analysis.
      PubDate: 2015-04-01
  • QuEChERS sample preparation in the simultaneous determination of
           diethylstilbestrol and ractopamine in food by gas-liquid chromatography
    • Abstract: Abstract A simple and rapid method has been proposed for the determination of 1–25 μg/kg of diethylstilbestrol and β-adrenostimulator ractopamine in food by gas-liquid chromatography with an electron-capture detector. The extraction of the target components was performed by the QuEChERS method; the additional purification of the extract and preconcentration in the determination of diethylstilbestrol has been performed by dispersion liquid-liquid microextraction with tetrachloromethane. Recovery was 92–110% and preconcentration factor, 40. The time of analysis is 1.5–2 h; the relative standard deviation of the results of analysis does not exceed 10 %.
      PubDate: 2015-04-01
  • Development of methods of the gas chromatographic determination of
           phenylcarboxylic acids in blood serum and their adaptation to clinical
           laboratory conditions
    • Abstract: Abstract A method has been developed for the determination of phenylcarboxylic acids (benzoic, p-hydroxyphenyllactic, p-hydroxyphenylacetic, phenyllactic, 3-phenylpropanoic, and phenylacetic) in blood serum by gas chromatography with a flame-ionization detector (FID). The quantitative characteristics of analysis obtained with the FID and mass spectrometric detectors are in the same range and exhibit common trends for different groups of samples. It has been shown that the reproducibility of the results increases with the addition of a stage of salting out to the sample preparation procedure. The accuracy of the results is estimated using the added-found method. A possibility of the application of widely used FID to the quantitative determination of phenylcarboxylic acids in blood serum has been demonstrated for routine clinical practice.
      PubDate: 2015-04-01
  • An ion-selective potentiometric sensor for hexafluoroarsenate
    • Abstract: Abstract Ion-selective potentiometric sensors (ion selective electrodes, ISEs) based on tetradecylphosphonium hexafluoroarsenate are developed for the determination of AsF 6 − ions. Their main parameters, such as selectivity, linearity range of response, detection limit, and also the effect of pH on the readings of electrodes are evaluated. The developed electrode demonstrated high selectivity to the AsF 6 − acido-complex in the presence of various anions. The detection limit goes up with increasing concentration of HF; for fluoridefree neat solutions of LiAsF6, it is 3 × 10−7, pAsF6 = 6.52; at the concentrations of HF 0.1 and 4 M, it is 1.5 × 10−6 M, pAsF6 = 5.82, and 7 × 10−6 M, pAsF6 = 5.15, respectively.
      PubDate: 2015-04-01
  • Development and validation of reversed phase HPLC method for the
           determination of vildagliptin using an experimental design
    • Abstract: Abstract A simple, robust and fast reversed phase HPLC method was developed and validated with UV detection (210 nm) for routine determination of vildagliptin. Chromatographic analysis was performed with mobile phase containing a mixture of 10 mM phosphate buffer (pH 4.6) and acetonitrile (85: 15, v/v) with flow rate of 1.0 mL/min. The procedure was validated as per International Conference on Harmonization (ICH) guidelines for linearity (correlation coefficient r 2 = 0.999), accuracy, intermediate precision and robustness. Experimental design was used during validation to calculate method robustness and intermediate precision. For testing robustness three factors were considered: pH of buffer, flow rate and percentage (v/v) of acetonitrile. From the analysis it was observed that an increase in the flow rate results in a decrease of drug found concentration, while the pH of buffer and percentage of organic modifier have no significant effect on the response. To measure intermediate precision, the variables considered were: analyst, equipment and number of days. The relative standard deviation (RSD) value (2.25%, n = 24) indicated a good precision for analytical method. The proposed method was simple, accurate, precise, sensitive and cost effective for further determination of vildagliptin.
      PubDate: 2015-04-01
  • Development and validation of a rapid derivative spectrophotometric method
           for simultaneous determination of acetaminophen, ibuprofen and caffeine
    • Abstract: Abstract A zero-crossing derivative spectrophotometric method was used for the simultaneous determination of acetaminophen, ibuprofen and caffeine. The derivative spectra of standard solutions of each compound were obtained at different orders to find out the suitable zero-crossing points. Under the optimized conditions, determination of acetaminophen was performed at wavelengths of 311 and 270 nm using the third order (Δλ = 24.5) and fourth order (Δλ = 12.0) derivative spectra, respectively. Ibuprofen and caffeine were determined at wavelengths of 235 and 300 nm using the second order (Δλ = 21.0) and fourth order (Δλ = 27.0) derivative spectra. The method was found to be linear (r 2 > 0.998) in the range of (μg/mL) 5–50 for acetaminophen, 5–30 for ibuprofen and 1–7 for caffeine in the presence of other compounds. The within-day and between-day precision and accuracy of the proposed method were acceptable (CV < 3% and error < 2%) for all three components and the proposed method was satisfactory for quality control purposes. The method was successfully applied to the simultaneous determination of acetaminophen, ibuprofen and caffeine in pharmaceutical dosage forms without any interference from excipients and there was no need to any prior separation before analysis.
      PubDate: 2015-03-01
  • 1,2-Naphthoquinone-4-sulfonic acid sodium salt as a reagent for
           spectrophotometric determination of rimantadine and memantine
    • Abstract: Abstract A selective ultraviolet and visible spectrophotometric method (UV-Vis) for the determination of memantine (MM) and rimantadine (RM) hydrochlorides after derivatization with 1,2-naphtoquinone-4-sulfonic acid sodium salt (NQS) and extraction with dichloromethane was developed and optimized. The reaction of the NQS (0.7%, w/v solution) with memantine was carried out for 40 min in a buffer medium of NaOH/KCl (pH 12.0) at 80°C. A mixture of NQS (0.2%) and rimantadine was heated for 20 min at 50°C, in a medium of NaOH/KCl (pH 12.0). The linearity of the determinations of MM (0.05–0.60 mg/mL) and RM (0.05–0.30 mg/mL) was evaluated. LOD (28 mg/mL for MM, 11 mg/mL for RM) and LOQ (84 mg/mL for MM, 32 mg/mL for RM) values and parameters of precision and accuracy were determined. The UV-Vis method for the determination of rimantadine hydrochloride tablets was validated (selectivity, linearity, precision, accuracy).
      PubDate: 2015-03-01
  • Determination of phenolic acids and a flavonoid in Eleusine coracana (L.)
           by semi-preparative HPLC photo diode array detector
    • Abstract: Abstract Semi preparative HPLC procedure is proposed for the determination of six phenolic acids and one flavonoid in Eleusine coracana (L.) with gradient elution and photodiode array detection. The influence of composition of the mobile phase concentration of the mix modifier and temperature on the separation of gallic acid, p-hydroxybenzoic, vanillic, caffeic, ferulic, and cinnamic acids and quercetin for 90 min is studied. The procedure was applied for the separation of phenolic compounds in methanolic extracts of Eleusine coracana (L.). The lower limits of quantification of phenolic compounds and the flavonoid are 0.050–0.150 μg/mL.
      PubDate: 2015-03-01
  • Application of cinnamoyl derivative as a new ligand for dispersive
           liquid-liquid microextraction and spectrophotometric determination of
    • Abstract: Abstract The method is based on the reaction of Co(II) with 3-[4-(dimethylamino)cinnamoyl]-4-hydroxy-6-methyl-2H-pyran-2-one (ligand) and a dimethylindocarbocyanine dye, followed by dispersive liquid-liquid microextraction of the ion associate formed and subsequent spectrophotometric detection. The appropriate experimental conditions were found to be: pH 9, 0.14 mM dye, toluene (extraction solvent) containing 2.25 mM of ligand, acetonitrile (dispersive solvent) and carbon tetrachloride (auxiliary solvent). Beer’s law is obeyed in the range 0.06–0.42 mg/L of Co(II) at a wavelength of 558 nm. The limit of detection, calculated as three times the standard deviation of the blank test (n = 10), was found to be 9 μg/L for Co(II). The method was applied to the determination of cobalt in spiked water samples and a vitamin B12 pharmaceutical injection.
      PubDate: 2015-03-01
  • A test strip for lead(II) based on gold nanoparticles multi-functionalized
           by DNAzyme and barcode DNA
    • Abstract: Abstract A simple, rapid, sensitive and selective test strip for the detection of lead(II) in water samples was developed. This method is based on gold nanoparticles multi-functionalized by 17E-17DS duplex and barcode DNA, AuNPs@(17E-17DS duplex & barcode DNA). The complex of 17E and 17DS (duplex) was constructed by the hybridization between 17E DNAzyme and its corresponding 17DS cleavage substrate. Because 17E DNAzyme has high specificity for lead(II), the presence of lead(II) induces 17E DNAzyme to specifically cleave 17DS. A barcode DNA complementary to the capture DNA was employed to reduce the amount of 17E-17DS duplex used and increase the capture probability of cleaved AuNPs@(17E-17DS duplex & barcode DNA) conjugates, and thus effectively improve the detection sensitivity. The test results for lead(II) could be visually obtained within 10 min without any instrument and sample pretreatment, with a detection limit 20 nM. In addition, the selectivity of this sensing system was investigated by challenging the sensor with other divalent metal ions, and no significant interference was found. Therefore, the developed test strip could be a potential on-site screening tool for the rapid detection of lead(II).
      PubDate: 2015-03-01
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