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  Subjects -> CHEMISTRY (Total: 846 journals)
    - ANALYTICAL CHEMISTRY (51 journals)
    - CHEMISTRY (596 journals)
    - CRYSTALLOGRAPHY (21 journals)
    - ELECTROCHEMISTRY (25 journals)
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ANALYTICAL CHEMISTRY (51 journals)

Showing 1 - 51 of 51 Journals sorted alphabetically
Accounts of Chemical Research     Full-text available via subscription   (Followers: 127)
Acta Analytica     Hybrid Journal   (Followers: 7)
Advances in Analytical Chemistry     Open Access   (Followers: 30)
American Journal of Analytical Chemistry     Open Access   (Followers: 32)
Analytica Chimica Acta     Hybrid Journal   (Followers: 36)
Analytical and Bioanalytical Chemistry     Hybrid Journal   (Followers: 30)
Analytical and Bioanalytical Chemistry Research     Open Access  
Analytical Chemistry     Full-text available via subscription   (Followers: 267)
Analytical Chemistry Insights     Open Access   (Followers: 23)
Analytical Chemistry Research     Open Access   (Followers: 8)
Analytical Letters     Hybrid Journal   (Followers: 10)
Analytical Spectroscopy Library     Full-text available via subscription   (Followers: 12)
Annual Review of Analytical Chemistry     Full-text available via subscription   (Followers: 11)
Biomonitoring     Open Access   (Followers: 2)
Chemical Data Collections     Hybrid Journal  
Chinese Journal of Analytical Chemistry     Full-text available via subscription   (Followers: 4)
Combinatorial Chemistry - an Online Journal     Open Access   (Followers: 3)
Composites Communications     Full-text available via subscription   (Followers: 1)
Comprehensive Analytical Chemistry     Full-text available via subscription   (Followers: 6)
Critical Reviews in Analytical Chemistry     Hybrid Journal   (Followers: 27)
Current Analytical Chemistry     Hybrid Journal   (Followers: 9)
Drug Testing and Analysis     Hybrid Journal   (Followers: 7)
Electroanalysis     Hybrid Journal   (Followers: 8)
Field Analytical Chemistry and Technology     Hybrid Journal   (Followers: 5)
Handbook of Analytical Separations     Full-text available via subscription   (Followers: 3)
Handbook of Thermal Analysis and Calorimetry     Full-text available via subscription   (Followers: 1)
International Journal of Analytical Chemistry     Open Access   (Followers: 22)
International Journal of Chemical and Analytical Science     Full-text available via subscription   (Followers: 3)
International Journal of Environmental Analytical Chemistry     Hybrid Journal   (Followers: 6)
International Journal of Polymer Analysis and Characterization     Hybrid Journal   (Followers: 7)
Journal of Analytical & Bioanalytical Techniques     Open Access   (Followers: 7)
Journal of Analytical Atomic Spectrometry     Full-text available via subscription   (Followers: 11)
Journal of Analytical Chemistry     Hybrid Journal   (Followers: 23)
Journal of Combinatorial Chemistry     Full-text available via subscription   (Followers: 1)
Journal of Electroanalytical Chemistry     Hybrid Journal   (Followers: 6)
Journal of Essential Oil Research     Hybrid Journal   (Followers: 3)
Journal of Radioanalytical and Nuclear Chemistry     Hybrid Journal   (Followers: 7)
Journal of Thermal Analysis and Calorimetry     Hybrid Journal   (Followers: 24)
Main Group Metal Chemistry     Hybrid Journal   (Followers: 2)
Microchemical Journal     Hybrid Journal   (Followers: 4)
Nigerian Journal of Chemical Research     Full-text available via subscription   (Followers: 2)
Phytochemical Analysis     Hybrid Journal   (Followers: 3)
Polish Journal of Chemical Technology     Open Access   (Followers: 2)
Reviews in Analytical Chemistry     Hybrid Journal   (Followers: 10)
Sample Preparation     Open Access   (Followers: 1)
Surface and Interface Analysis     Hybrid Journal   (Followers: 15)
Techniques and Instrumentation in Analytical Chemistry     Full-text available via subscription   (Followers: 6)
TrAC Trends in Analytical Chemistry     Full-text available via subscription   (Followers: 55)
Trends in Environmental Analytical Chemistry     Hybrid Journal   (Followers: 3)
Vibrational Spectroscopy     Hybrid Journal   (Followers: 13)
World Journal of Analytical Chemistry     Open Access   (Followers: 2)
Journal Cover Journal of Analytical Chemistry
  [SJR: 0.268]   [H-I: 23]   [23 followers]  Follow
    
   Hybrid Journal Hybrid journal (It can contain Open Access articles)
   ISSN (Print) 1608-3199 - ISSN (Online) 1061-9348
   Published by Springer-Verlag Homepage  [2354 journals]
  • Triangular silver nanoplates as a spectrophotometric reagent for the
           determination of mercury(II)
    • Authors: A. A. Furletov; V. V. Apyari; A. V. Garshev; S. G. Dmitrienko; Yu. A. Zolotov
      Pages: 1203 - 1207
      Abstract: The applicability of triangular silver nanoplates (TNPs) as a spectrophotometric reagent for the determination of mercury(II) in an aqueous solution was estimated. The method is based on the oxidation of TNPs with a mean edge length of 52 nm and thickness of 4 nm by mercury(II) ions, which is accompanied by a decrease in the surface plasmon resonance of nanoparticles. The effect of reaction time, pH of solution, and TNP concentration on the sensitivity of mercury(II) determination was studied. The limit of mercury(II) detection under the selected conditions was 0.022 μg/mL.
      PubDate: 2017-12-01
      DOI: 10.1134/s1061934817120061
      Issue No: Vol. 72, No. 12 (2017)
       
  • Determination of copper in urine by diffuse reflectance spectroscopy
    • Authors: V. P. Dedkova; O. P. Shvoeva; A. A. Grechnikov
      Pages: 1208 - 1211
      Abstract: A possibility of determining copper(II) after adsorption on polyacrylonitrile fiber filled with a KU-2 cation exchanger with immobilized 1-(2-pyridylazo)-2-naphthol (PANF–KU-2–PAN) is studied. The diffuse reflectance spectra of the carrier discs before and after the adsorption of copper in the batch mode are recorded. The dependences of the analytical signals of the copper complex on PANF–KU-2–PAN on adsorption conditions are studied. The conditions for determining 0.05–0.40 μg/mL of copper(II) by measuring diffuse reflection coefficient at 640 nm or visually by a color scale after the adsorption of copper from 20 mL of a solution containing 0.01 M of HCl are found. The determination of 0.1 μg/mL of copper does not interfered with equal amounts of Co, Zn, and Pb and double amounts of Ag, Fe(III), Cd, Mn(II), Bi(III), and Cr(III). The procedure is used for urine analysis. The following conditions of the preparation of urine samples for the determination of copper were selected: boiling with hydrogen peroxide followed by acidification to pH 2. A procedure for determining copper in urine with a limit of detection of 0.03 μg/mL was developed; the relative standard deviation does not exceed 25%; the duration of analysis of 5–6 samples is 30–35 min.
      PubDate: 2017-12-01
      DOI: 10.1134/s1061934817120048
      Issue No: Vol. 72, No. 12 (2017)
       
  • Spectrophotometric determination of proteins in biological fluids
    • Authors: P. V. Anisimovich; T. B. Pochinok; E. V. Tokareva
      Pages: 1212 - 1218
      Abstract: A comparative analysis of procedures of the spectrophotometric determination of total protein with various organic dyes, Bromocresol Green, Bromophenol Blue, and Pyrogallol Red, in biological fluids is presented. It is shown that the results of determination with various dyes can differ because of the specific features of reagent interaction with the components of biological fluids. A new organic reagent, Bromopyrogallol Red, possessing equal sensitivity to different protein fractions (albumins and globulins) and ensuring a minimum error of the determination of total protein in clinical examinations using calibration solutions of various compositions is proposed. A procedure for the determination of total protein in biological fluids is developed and tested on real samples of urine and blood serum.
      PubDate: 2017-12-01
      DOI: 10.1134/s1061934817120024
      Issue No: Vol. 72, No. 12 (2017)
       
  • Identification of polyethanolamines by chromatography–mass
           spectrometry
    • Authors: M. V. Shashkov; E. E. Sergeev
      Pages: 1219 - 1225
      Abstract: Presumable structures of polyethanolamines, synthesized by the catalytic β-hydroxyethylation of ammonia with an excess of ethylene oxide are determined by gas chromatography–electron ionization mass spectrometry and tandem mass spectrometry qualitatively, following fragmentation ways and also taking into account retention data. The preferable paths of consecutive reactions of the synthesis of polyethanolamines in a homologous series of isomers are found.
      PubDate: 2017-12-01
      DOI: 10.1134/s1061934817120103
      Issue No: Vol. 72, No. 12 (2017)
       
  • Adsorption and selective properties of
           4-{4-[4(S)-2-methyl-1-butoxybenzoyloxy]phenyldiazenyl}benzaldehyde in
           gas–mesophase chromatography
    • Authors: S. A. Kuvshinova; G. V. Kuvshinov; O. I. Koifman
      Pages: 1226 - 1232
      Abstract: Adsorption of 16 organic compounds from the gas phase by 4-{4-[4(S)-2-methyl-1-butoxybenzoyloxy]phenyldiazenyl}benzaldehyde was studied by gas chromatography. It was shown by means of differential scanning calorimetry that 4-{4-[4(S)-2-methyl-1-butoxybenzoyloxy]phenyldiazenyl]benzaldehyde is an enantiotropic polymorphic mesogen and forms smectic and nematic liquid crystal phases. Electron-donor isomers of methylpyridine and dimethylpyridine, isomers of weakly polar xylenes and cresols, and enantiomers of 2,3-butanediol and terpene hydrocarbons, capable of various types of intermolecular interactions with mesogenic aldehyde, were selected as adsorbates. Specific retention volumes of adsorbates and criteria for their separation were calculated. The effect of temperature and chemical nature of the adsorbates on their adsorption redistribution in the gas–liquid crystal system is discussed. It was found experimentally that the adsorbent based on 4-{4-[4(S)-2-methyl-1-butoxybenzoyloxy]phenyldiazeny}lbenzaldehyde exhibits high selectivity for close-boiling organic compounds of various nature and good efficiency and productivity in their separation.
      PubDate: 2017-12-01
      DOI: 10.1134/s1061934817120073
      Issue No: Vol. 72, No. 12 (2017)
       
  • Chromatographic behavior of anthocyanins on a C10CN stationary phase
    • Authors: V. I. Deineka; Ya. Yu. Kul’chenko; L. A. Deineka
      Pages: 1233 - 1238
      Abstract: The selectivity of the separation of some anthocyanins on Diasphere-11-C10CN stationary phase (phase I) is compared with the traditional reversed Symmetry C18 phase (phase II). It is found that, in contrast to phase II, phase I is effective in the separation of isomeric pairs of anthocyanins of 6-hydroxycyanidin-3-rutinoside and delphinidin-3-rutinoside, 6-hydroxypelargonidin-3-rutinoside and cyanidin-3-rutinoside, which ensures the determination of anthocyanins of Alstroemeria flowers. A comparison of separation maps shows that, on phase I, as compared with phase II, retention does not decrease so much, when OH groups are added to the anthocyanidin structure; trend lines for 3-mono-, di-, and triglucosides have a higher slope, and the addition of a glucosidic substituent at position 5 results in a more significant decrease in the retention of anthocyanins. Different selectivity of the separation of anthocyanins on phase I makes this separation version a good alternative to traditional reversed phase chromatography.
      PubDate: 2017-12-01
      DOI: 10.1134/s106193481712005x
      Issue No: Vol. 72, No. 12 (2017)
       
  • Determination of alkyl- and alkanolamines in drinking and natural waters
           by capillary electrophoresis with isotachophoretic on-line
           preconcentration
    • Authors: Yu. Malinina; M. Ya. Kamentsev; L. N. Moskvin; N. M. Yakimova; I. D. Kuchumova
      Pages: 1239 - 1242
      Abstract: A procedure is developed for the determination of several amines in drinking and natural waters by capillary electrophoresis with isotachophoretic on-line preconcentration without sample preparation. A background electrolyte based on acridine as an absorbing ion is proposed for analysis with isotachophoretic on-line preconcentration and indirect photometric detection. The sample was injected in the hydrodynamic mode. The procedure was tested on drinking and natural water samples. The accuracy of data obtained was confirmed by the added–found method. The analytical range was from 0.25 to 5 mg/L. The time of one analysis was 5–6 min.
      PubDate: 2017-12-01
      DOI: 10.1134/s1061934817120085
      Issue No: Vol. 72, No. 12 (2017)
       
  • Determination of sulfur-containing anions in alkaline solutions using
           arrays of DP-sensors based on hybrid perfluorinated membranes with
           proton-donor dopants
    • Authors: A. V. Parshina; T. S. Denisova; E. Yu. Safronova; Yu. A. Karavanova; D. V. Safronov; O. V. Bobreshova; A. B. Yaroslavtsev
      Pages: 1243 - 1250
      Abstract: The influence of proton-donor properties and concentration of dopant nanoparticles introduced into Nafion and MF-4SС perfluorosulfonic cation-exchange membranes on the characteristics of cross-sensitive DP-sensors (sensors whose analytical signal is the Donnan potential) in alkaline solutions of sulfur-containing organic compounds were studied. The dopants were acid salts of heteropoly acids (HPAs) and hydrated silica SiO2 and zirconia ZrO2 surface-modified with sulfur-containing groups and an acid HPA salt. A correlation was revealed between the DP-sensor sensitivity to anions (and zwitter-ions) in alkaline solutions, size and proton-donor ability of the added particles, and diffusion permeability of hybrid membranes. Optimum compositions of membranes for arrays of cross-sensitive DP-sensors ensuring the simultaneous determination of cations and anions (and zwitter-ions) in the test solutions with an error of less than 18% were selected.
      PubDate: 2017-12-01
      DOI: 10.1134/s1061934817120097
      Issue No: Vol. 72, No. 12 (2017)
       
  • Elimination of the interfering effect of hydrogen on the determination of
           palladium by stripping voltammetry
    • Authors: N. A. Kolpakova; S. M. Panova; Yu. A. Os’kina; Zh. K. Sabitova
      Pages: 1251 - 1254
      Abstract: The effect of hydrogen on the electrooxidation current of a palladium–hydrogen precipitate is studied. It is shown that the UV irradiation of the solution changes the mechanism of the formation of molecular hydrogen in the electrochemical deposition of palladium. A procedure is developed for determining palladium in platinum metal preconcentrates by stripping voltammetry.
      PubDate: 2017-12-01
      DOI: 10.1134/s1061934817100070
      Issue No: Vol. 72, No. 12 (2017)
       
  • Identification of endogenous and anthropogenic hydrocarbons in bottom
           deposits of peat lakes and evaluation of their contribution to the
           “hydrocarbon index”
    • Authors: E. S. Brodskii; A. A. Shelepchikov; E. Ya. Mir-Kadyrova; G. A. Kalinkevich
      Pages: 1255 - 1262
      Abstract: Gas chromatography with mass spectrometric detection was used to analyze bitumens isolated from bottom sediments of peat lakes contaminated with petroleum products. Endogenous hydrocarbons are characterized by the presence of n-alkanes with an odd number of carbon atoms in the molecule in the characteristic region of C23–C33, the absence of a “hump” characteristic of oil products in the chromatogram, and the presence of light hydrocarbons, eluting in the initial part of the chromatogram (light hydrocarbons are usually lost when the sample is dried). The distribution profile of odd n-alkanes is used to assess the contribution of endogenous hydrocarbons to the “hydrocarbon index” with the help of the pattern recognition method. The concentration of light hydrocarbons is from 50 and 300–400 to 3500–5000 mg/kg for a number of samples and even up to 26000 mg/kg in some samples. The concentration of petroleum hydrocarbons and heteroatomic compounds varies from the lowest values of 30–80 mg/kg up to 20000 mg/kg and higher.
      PubDate: 2017-12-01
      DOI: 10.1134/s1061934817120036
      Issue No: Vol. 72, No. 12 (2017)
       
  • A rapid field test method for the determination of hydrogen sulfide and
           sulfides in waters with gas preextraction
    • Authors: M. O. Gorbunova; E. M. Bayan
      Pages: 1263 - 1269
      Abstract: A rapid test method was developed for the determination of hydrogen sulfide and sulfides in waters using a potassium chloride-impregnated test paper with color intensity evaluation of the formed CdS zone by colorimetry and diffuse reflectance spectroscopy. The determination conditions, viz. acidity, gas preexraction time, air pumping rate, and working concentration range (0.005–0.16 mg of Н2S/L), were optimized. The procedure proposed is easy-to-perform, and the time of single determination is 20 min; in addition, the procedure is cost effective, sensitive, selective, does not require expensive equipment and expertise of executor, and is not inferior in accuracy to photometric methods. The procedure was tested on real water samples. The concentration hydrogen sulfide in the Don and Temernik rivers in Rostov-on-Don is not higher than the maximum permissible concentration (MPC).
      PubDate: 2017-12-01
      DOI: 10.1134/s1061934817100057
      Issue No: Vol. 72, No. 12 (2017)
       
  • Use of household color-recording devices in quantitative chemical analysis
    • Authors: V. V. Apyari; M. V. Gorbunova; A. I. Isachenko; S. G. Dmitrienko; Yu. A. Zolotov
      Pages: 1127 - 1137
      Abstract: Published data on the use of household color-recording devices, such as office scanners, digital cameras, web cameras, mobile phones, and smartphones, in quantitative chemical analysis are generalized and systematized. The main approaches underlying the use of these devices for recording optical analytical signals are discussed. Methodological approaches used in the measurements and processing of the results are described. Examples of the determination of chemical compounds and ions using household color-recording devices are given.
      PubDate: 2017-11-01
      DOI: 10.1134/s106193481711003x
      Issue No: Vol. 72, No. 11 (2017)
       
  • Use of silver nanoparticles in spectrophotometry
    • Authors: E. A. Terenteva; V. V. Apyari; E. V. Kochuk; S. G. Dmitrienko; Yu. A. Zolotov
      Pages: 1138 - 1154
      Abstract: Published data on the application of silver nanoparticles to spectrophotometry are summarized. Data on methods of synthesis of silver nanoparticles and their optical properties are presented. The main approaches to the spectrophotometric determination of substances using silver nanoparticles are discussed. Examples of the determination of metal ions, anions, and organic compounds are given.
      PubDate: 2017-11-01
      DOI: 10.1134/s1061934817110107
      Issue No: Vol. 72, No. 11 (2017)
       
  • Determination of explosive vapor concentrations with remote sampling in
           the control of objects
    • Authors: V. M. Gruznov; M. N. Baldin; M. V. Pryamov; E. M. Maksimov
      Pages: 1155 - 1160
      Abstract: A procedure is proposed for the determination of the vapor concentration of 2,4,6-trinitrotoluene (TNT) in air at a level of 10–16 g/cm3 in the control of objects for the presence of TNT. The procedure includes preconcentration of TNT vapors and gas chromatographic determination with a limit of TNT detection at a level of 0.08 ± 0.02 pg in a sample. The procedure was applied to the control objects in cells of typical automatic luggage locker with sampling through sampling air ducts. A measure of sample losses as the breakthrough of vapors through sampling air ducts and gas dynamic conditions for the reduction of vapor losses as the ratio of diffusion coefficient to the air duct flow rate were proposed. The time constant of the saturation of the sampling system with TNT vapors and the time constant of its cleaning were determined. It was shown that TNT vapors can be detected virtually satisfactorily near TNT-containing objects with sampling through long channels.
      PubDate: 2017-11-01
      DOI: 10.1134/s1061934817110041
      Issue No: Vol. 72, No. 11 (2017)
       
  • Adsorption–photometric determination of lead in cattle liver
    • Authors: R. A. Alieva; U. M. Abilova; N. S. Guseinova; F. M. Chyragov
      Pages: 1161 - 1166
      Abstract: A styrene–maleic anhydride copolymer is synthesized, modified in the presence of p-sulfoaniline and formaldehyde, and a new polymer adsorbent is obtained and identified by IR spectroscopy. The ionization constants of ionogenic groups in the adsorbent are determined by the potentiometric method. The adsorption and desorption of lead(II) on the obtained adsorbent are investigated, and optimal conditions of preconcentration are determined. An adsorption–photometric procedure for the determination of lead is proposed, including the adsorption preconcentration of lead(II) from a buffer solution with pH 6 and desorption with a solution of HCl (with the desorption rate of up to 99%). The procedure was used to determine lead in the cattle liver.
      PubDate: 2017-11-01
      DOI: 10.1134/s1061934817110028
      Issue No: Vol. 72, No. 11 (2017)
       
  • Determination of mass absorption coefficient in two-layer thin-film Cr/V
           and V/Cr systems by X-ray fluorescence spectrometry
    • Authors: N. I. Mashin; E. A. Krylov; E. A. Chernyaeva; A. V. Ershov; E. O. Zimina
      Pages: 1167 - 1171
      Abstract: A method is proposed for the determination of mass absorption coefficient in the analysis of two-layer thin-film V/Cr and Cr/V systems on Polikor substrates by X-ray fluorescence spectrometry. Simply fabricated and unified film layers formed by applying vanadium and chromium on polymer film substrates are used. Correction coefficients taking into account the attenuation of primary radiation of X-ray tube and analytical line of an element from the lower layer in the upper layer are calculated.
      PubDate: 2017-11-01
      DOI: 10.1134/s1061934817090064
      Issue No: Vol. 72, No. 11 (2017)
       
  • Sorption, thermodynamic, and selective properties of camphor-substituted
           copper(II) tetrapyrazinoporphyrazine as a stationary phase for gas
           chromatography
    • Authors: G. V. Kuvshinov; S. A. Kuvshinova; O. I. Koifman
      Pages: 1172 - 1177
      Abstract: The surface of a Chromaton N-AW diatomite adsorbent was modified with copper(II) tetra(1',7',7'-trimethylbicyclo[2.2.1]heptano-[2',3'-b]-pyrazino)porphyrazine. Adsorption of vapors of 20 organic compounds on the surface of the modified adsorbent was studied by inverse gas chromatography. Electron-donor isomers of methylpyridine and dimethylpyridine, isomers of weakly polar xylenes and cresols, aliphatic alcohols, and other hydrocarbons capable of showing various types of intermolecular interactions with the complex of camphor-substituted tetrapyrazinoporphyrazine with copper(II) were chosen as adsorbates. Specific retention volumes of adsorbates, heat and adsorption entropy, and Gibbs adsorption energy were calculated. The effects of temperature and chemical nature of the adsorbates on the thermodynamic characteristics of sorption are discussed. Factors of separation of closely-boiling hydrocarbons are calculated. It has been found experimentally that the macroheterocycle-based adsorbent shows high selectivity to closely-boiling compounds of various types, unattainable for the unmodified adsorbent.
      PubDate: 2017-11-01
      DOI: 10.1134/s1061934817110065
      Issue No: Vol. 72, No. 11 (2017)
       
  • Application of high-performance liquid chromatography to the determination
           of the concentration of lichen secondary metabolites
    • Authors: I. A. Prokopiev; A. L. Shavarda; G. V. Filippova; A. A. Shein
      Pages: 1178 - 1183
      Abstract: Preparative isolation of aromatic metabolites from lichens of the Cladonia genus (C. stellaris, C. arbuscula, C. amaurocraea, and C. rangiferina) growing in Central Yakutia was carried out. Identification by IR, UV, and time-of-flight mass spectrometry has shown that the isolated compounds belong to the group of lichen substances. It was shown that the component composition of the studied lichens corresponds to the previously described one. At the same time, the concentration of perlatolic and barbatic acids in C. stellaris and C. amaurocrae lichens, respectively, growing in Central Yakutia found by HPLC is higher than in similar types of temperate climatic zones.
      PubDate: 2017-11-01
      DOI: 10.1134/s1061934817090088
      Issue No: Vol. 72, No. 11 (2017)
       
  • Application of chromatography–mass spectrometry methods to the control
           of sport nutrition and medicines marketed via internet
    • Authors: A. Z. Temerdashev; A. A. Azaryan; A. V. Labutin; M. A. Dikunets; I. O. Zvereva; I. I. Podol’skii; G. T. Berodze; I. A. Balabaev
      Pages: 1184 - 1192
      Abstract: Several sport nutrition products and doping drugs sold in the period from 2014 to 2016 were studied using gas and liquid chromatography coupled with mass-spectrometry. In the study, WADA-banned substances were detected in the composition of pre-workout supplements, fat burners, and prohormones. A series of selective androgen receptor modulators and peptide doping drugs were also studied. It was shown that, in some cases, preparations can be adulterated.
      PubDate: 2017-11-01
      DOI: 10.1134/s1061934817110090
      Issue No: Vol. 72, No. 11 (2017)
       
  • Procedure for setting control for the turnover of new, potentially
           hazardous psychoactive substances. Detection of metabolites of a new
           APINAC psychoactive compound in rat urine by gas and liquid chromatography
           with mass spectrometry detection
    • Authors: S. A. Savchuk; S. A. Appolonova; O. M. Kogdas’; V. N. Unizhaev; O. S. Gorina; L. N. Rizvanova; N. V. Samyshkina; K. M. Shestakova
      Pages: 1193 - 1202
      Abstract: The appearance of a new APINAC compound (AKB-57, ACBL(N)-018, adamantan-1-yl-1-pentyl-1H-indazol-3-carboxylate) in the Russian market of psychoactive drugs led to the need in setting measures of state control over its turnover and in solving the problem of categorizing this compound as a potentially hazardous psychoactive substance. To establish these control measures, it was necessary to determine the appropriate chromatographic–mass spectrometric characteristics and to search for its metabolites for their subsequent automated detection. The structure of an APINAC molecule has significant similarity with the molecules of other synthetic cannabinoids. In this paper, primary information on the metabolism of APINAC in the body of rats is presented. A number of putative metabolites, which are the products of hydrolysis of the initial structure and additional monohydroxylation of these products, carbonylation and carboxylation of the lateral N-pentyl chain of indazole-containing metabolites, were detected in rat urine by liquid chromatography–mass spectrometry in the mode of measurement of exact masses and gas chromatography–mass spectrometry. It was found that the formation of glucuronides is characteristic for 1-adamantol and its monohydroxylated metabolite and for the indazole-containing product of hydrolysis of APINAC. The presented mass spectra and retention characteristics of the detected metabolites can help in the detection of these (or similar) compounds in human urine.
      PubDate: 2017-11-01
      DOI: 10.1134/s1061934817110089
      Issue No: Vol. 72, No. 11 (2017)
       
 
 
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