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Open Access journal
ISSN (Print) 1745-6150
Published by Biomed Central Ltd. [287 journals]
- TFAP2A is a component of the ZEB1/2 network that regulates TGFB1-induced
epithelial to mesenchymal transition
Authors: Yoana Dimitrova; Andreas J. Gruber, Nitish Mittal, Souvik Ghosh, Beatrice Dimitriades, Daniel Mathow, William Aaron Grandy, Gerhard Christofori Mihaela Zavolan
Abstract: The transition between epithelial and mesenchymal phenotypes (EMT) occurs in a variety of contexts. It is critical for mammalian development and it is also involved in tumor initiation and progression. Master ...
- Adaptive multiscapes: an up-to-date metaphor to visualize molecular
Authors: Pablo Catalán; Clemente F. Arias, Jose A. Cuesta Susanna Manrubia
Abstract: Wright’s metaphor of the fitness landscape has shaped and conditioned our view of the adaptation of populations for almost a century. Since its inception, and including criticism raised by Wright himself, the ...
- Post translational modification of Parkin
Authors: Joy Chakraborty; Valentina Basso Elena Ziviani
Abstract: Mutations in the gene encoding for the E3 ubiquitin ligase Parkin are associated to a rare form of familiar autosomal recessive Parkinsonism. Despite decades of research on the Parkin protein, whose structure ...
- Evolution of RNA- and DNA-guided antivirus defense systems in prokaryotes
and eukaryotes: common ancestry vs convergence
Authors: Eugene V. Koonin
Abstract: Complementarity between nucleic acid molecules is central to biological information transfer processes. Apart from the basal processes of replication, transcription and translation, complementarity is also emp...
- Consistent metagenomic biomarker detection via robust PCA
Authors: Mustafa Alshawaqfeh; Ahmad Bashaireh, Erchin Serpedin Jan Suchodolski
Abstract: Recent developments of high throughput sequencing technologies allow the characterization of the microbial communities inhabiting our world. Various metagenomic studies have suggested using microbial taxa as p...