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  Subjects -> BUSINESS AND ECONOMICS (Total: 2509 journals)
    - ACCOUNTING (62 journals)
    - BANKING AND FINANCE (220 journals)
    - BUSINESS AND ECONOMICS (1016 journals)
    - CONSUMER EDUCATION AND PROTECTION (21 journals)
    - COOPERATIVES (1 journals)
    - Economic Sciences: General (103 journals)
    - ECONOMIC SYSTEMS AND THEORIES, ECONOMIC HISTORY (99 journals)
    - INSURANCE (28 journals)
    - INTERNATIONAL COMMERCE (109 journals)
    - INTERNATIONAL DEVELOPMENT AND ASSISTANCE (56 journals)
    - INVESTMENTS (13 journals)
    - LABOR AND INDUSTRIAL RELATIONS (25 journals)
    - MACROECONOMICS (12 journals)
    - MANAGEMENT (423 journals)
    - MARKETING AND PURCHASING (51 journals)
    - PERSONNEL MANAGEMENT (80 journals)
    - PRODUCTION OF GOODS AND SERVICES (135 journals)
    - PUBLIC FINANCE, TAXATION (31 journals)
    - SMALL BUSINESS (23 journals)
    - TRADE AND INDUSTRIAL DIRECTORIES (1 journals)

BUSINESS AND ECONOMICS (1016 journals)            First | 3 4 5 6 7 8 9 10 | Last

Journal of Global Optimization     Hybrid Journal   (4 followers)
Journal of Hazardous Materials     Hybrid Journal   (8 followers)
Journal of Health Management     Hybrid Journal   (8 followers)
Journal of Health Organisation and Management     Hybrid Journal   (4 followers)
Journal of Housing Economics     Hybrid Journal   (2 followers)
Journal of Human Resource Costing & Accounting     Hybrid Journal   (2 followers)
Journal of Hydrodynamics, Ser. B     Full-text available via subscription   (1 follower)
Journal of Indian Business Research     Hybrid Journal  
Journal of Industrial Economics     Hybrid Journal   (13 followers)
Journal of Industrial Relations     Hybrid Journal   (6 followers)
Journal of Industry, Competition and Trade     Hybrid Journal   (6 followers)
Journal of Institutional Economics     Hybrid Journal   (5 followers)
Journal of Intellectual Capital     Hybrid Journal   (4 followers)
Journal of Intelligence Studies in Business     Open Access   (1 follower)
Journal of Intergenerational Relationships     Hybrid Journal   (2 followers)
Journal of International Academic Research     Open Access   (1 follower)
Journal of International Business Research     Full-text available via subscription   (1 follower)
Journal of International Business Studies     Partially Free   (13 followers)
Journal of International Education in Business     Hybrid Journal   (1 follower)
Journal of Internet Commerce     Hybrid Journal   (3 followers)
Journal of Language, Technology & Entrepreneurship in Africa     Open Access  
Journal of Law and Economics     Full-text available via subscription   (28 followers)
Journal of Law, Economics, and Organization     Hybrid Journal   (14 followers)
Journal of Legal Studies     Full-text available via subscription   (29 followers)
Journal of Manufacturing Processes     Full-text available via subscription   (6 followers)
Journal of Material Cycles and Waste Management     Hybrid Journal   (3 followers)
Journal of Mathematical Economics     Hybrid Journal   (3 followers)
Journal of Media Economics     Hybrid Journal   (4 followers)
Journal of Medical Economics     Hybrid Journal   (4 followers)
Journal of Monetary Economics     Hybrid Journal   (23 followers)
Journal of Money Laundering Control     Hybrid Journal   (3 followers)
Journal of Money, Credit and Banking     Hybrid Journal   (17 followers)
Journal of Multi-Criteria Decision Analysis     Hybrid Journal   (1 follower)
Journal of MultiDisciplinary Evaluation     Open Access  
Journal of Multinational Financial Management     Hybrid Journal   (3 followers)
Journal of Neuroscience, Psychology, and Economics     Full-text available via subscription   (4 followers)
Journal of Organizational Behavior     Hybrid Journal   (17 followers)
Journal of Organizational Behavior Management     Hybrid Journal   (8 followers)
Journal of Organizational Computing and Electronic Commerce     Hybrid Journal   (1 follower)
Journal of Payments Strategy & Systems     Full-text available via subscription   (4 followers)
Journal of Peasant Studies     Hybrid Journal   (7 followers)
Journal of Pension Economics and Finance     Hybrid Journal   (5 followers)
Journal of Policy Analysis and Management     Hybrid Journal   (12 followers)
Journal of Policy Modeling     Hybrid Journal   (7 followers)
Journal of Population Economics     Hybrid Journal   (10 followers)
Journal of Positive Psychology     Hybrid Journal   (9 followers)
Journal of Post Keynesian Economics     Full-text available via subscription   (4 followers)
Journal of Poverty     Hybrid Journal   (8 followers)
Journal of Productivity Analysis     Hybrid Journal   (1 follower)
Journal of Property Research     Hybrid Journal   (7 followers)
Journal of Regional Analysis and Policy     Open Access  
Journal of Regulatory Economics     Hybrid Journal   (6 followers)
Journal of Retailing     Hybrid Journal   (6 followers)
Journal of Revenue and Pricing Management     Partially Free   (4 followers)
Journal of Risk and Uncertainty     Hybrid Journal   (18 followers)
Journal of Scheduling     Hybrid Journal   (3 followers)
Journal of Securities Compliance     Full-text available via subscription  
Journal of Securities Operations & Custody     Full-text available via subscription   (2 followers)
Journal of Social Entrepreneurship     Hybrid Journal   (2 followers)
Journal of South Asian Development     Hybrid Journal   (2 followers)
Journal of Sports Media     Full-text available via subscription   (3 followers)
Journal of Sustainable Society     Open Access   (6 followers)
Journal of Systems and Information Technology     Hybrid Journal   (4 followers)
Journal of Taxation and Regulation of Financial Institutions     Full-text available via subscription   (5 followers)
Journal of Technology Management & Innovation     Open Access   (1 follower)
Journal of the Asia Pacific Economy     Hybrid Journal  
Journal of the European Economic Association     Hybrid Journal   (11 followers)
Journal of the Knowledge Economy     Hybrid Journal   (2 followers)
Journal of the Operations Research Society of China     Hybrid Journal   (2 followers)
Journal of the University of Ruhuna     Open Access  
Journal of Transport Economics and Policy     Full-text available via subscription   (13 followers)
Journal of Trust Research     Hybrid Journal   (1 follower)
Journal of Urban Economics     Hybrid Journal   (12 followers)
Journal of Workplace Learning     Hybrid Journal   (6 followers)
Journal of Workplace Rights     Full-text available via subscription   (3 followers)
Journal of World Business     Hybrid Journal   (5 followers)
Journal on Innovation and Sustainability     Open Access  
Jurnal Manajemen & Agribisnis     Open Access   (2 followers)
Knowledge Management Research & Practice     Hybrid Journal   (13 followers)
Kredit und Kapital     Full-text available via subscription   (2 followers)
Kyklos     Hybrid Journal   (5 followers)
La Revue des Sciences de Gestion, Direction et Gestion     Full-text available via subscription  
Lab on a Chip     Full-text available via subscription   (19 followers)
Labour     Hybrid Journal   (5 followers)
Labour Economics     Hybrid Journal   (8 followers)
Labour: Journal of Canadian Labour Studies / Le Travail : revue d'√Čtudes Ouvri√®res Canadiennes     Full-text available via subscription   (6 followers)
Land Degradation and Development     Hybrid Journal   (6 followers)
Language Learning and Development     Hybrid Journal   (6 followers)
Language Sciences     Hybrid Journal   (3 followers)
Latin American Business Review     Hybrid Journal  
Latin American Journal of Business Management     Open Access  
Letters in Spatial and Resource Sciences     Hybrid Journal   (2 followers)
Logistics Research     Hybrid Journal   (5 followers)
Long Range Planning     Hybrid Journal   (6 followers)
Main Economic Indicators - Principaux indicateurs economiques     Full-text available via subscription   (3 followers)
Management Dynamics in the Knowledge Economy     Open Access   (1 follower)
Management of Environmental Quality: An International Journal     Hybrid Journal   (4 followers)
Management Science and Economic Review     Open Access  
Margin The Journal of Applied Economic Research     Hybrid Journal   (5 followers)
Maritime Economics & Logistics     Hybrid Journal   (3 followers)

  First | 3 4 5 6 7 8 9 10 | Last

Proceedings of the National Academy of Sciences    [314 followers]  Follow    
  Full-text available via subscription Subscription journal
     ISSN (Print) 0027-8424 - ISSN (Online) 1091-6490
     Published by Proceedings of the National Academy of Sciences (PNAS) Homepage  [1 journal]   [SJR: 5.473]   [H-I: 485]
  • Compound facial expressions of emotion [Computer Sciences]
    • Authors: Du, S; Tao, Y, Martinez, A. M.
      Pages: E1454 - E1462
      Abstract: Understanding the different categories of facial expressions of emotion regularly used by us is essential to gain insights into human cognition and affect as well as for the design of computational models and perceptual interfaces. Past research on facial expressions of emotion has focused on the study of six basic...
      PubDate: 2014-04-15T09:08:15-07:00
      DOI: 10.1073/pnas.1322355111|hwp:master-id:pnas;1322355111
      Issue No: Vol. 111, No. 15 (2014)
       
  • Epidermal Wnt regulates adipocyte differentiation [Developmental Biology]
    • Authors: Donati, G; Proserpio, V, Lichtenberger, B. M, Natsuga, K, Sinclair, R, Fujiwara, H, Watt, F. M.
      Pages: E1501 - E1509
      Abstract: It has long been recognized that the hair follicle growth cycle and oscillation in the thickness of the underlying adipocyte layer are synchronized. Although factors secreted by adipocytes are known to regulate the hair growth cycle, it is unclear whether the epidermis can regulate adipogenesis. We show that inhibition of...
      PubDate: 2014-04-15T09:08:15-07:00
      DOI: 10.1073/pnas.1312880111|hwp:master-id:pnas;1312880111
      Issue No: Vol. 111, No. 15 (2014)
       
  • Deepwater Horizon impacts on pelagic fish embryos [Environmental Sciences]
    • Authors: Incardona, J. P; Gardner, L. D, Linbo, T. L, Brown, T. L, Esbaugh, A. J, Mager, E. M, Stieglitz, J. D, French, B. L, Labenia, J. S, Laetz, C. A, Tagal, M, Sloan, C. A, Elizur, A, Benetti, D. D, Grosell, M, Block, B. A, Scholz, N. L.
      Pages: E1510 - E1518
      Abstract: The Deepwater Horizon disaster released more than 636 million L of crude oil into the northern Gulf of Mexico. The spill oiled upper surface water spawning habitats for many commercially and ecologically important pelagic fish species. Consequently, the developing spawn (embryos and larvae) of tunas, swordfish, and other large predators...
      PubDate: 2014-04-15T09:08:15-07:00
      DOI: 10.1073/pnas.1320950111|hwp:master-id:pnas;1320950111
      Issue No: Vol. 111, No. 15 (2014)
       
  • DENND1A.V2 produces a PCOS phenotype [Medical Sciences]
    • Authors: McAllister, J. M; Modi, B, Miller, B. A, Biegler, J, Bruggeman, R, Legro, R. S, Strauss, J. F.
      Pages: E1519 - E1527
      Abstract: Polycystic ovary syndrome (PCOS), characterized by increased ovarian androgen biosynthesis, anovulation, and infertility, affects 5–7% of reproductive-age women. Genome-wide association studies identified PCOS candidate loci that were replicated in subsequent reports, including DENND1A, which encodes a protein associated with clathrin-coated pits where cell-surface receptors reside. However, these studies provided no...
      PubDate: 2014-04-15T09:08:15-07:00
      DOI: 10.1073/pnas.1400574111|hwp:master-id:pnas;1400574111
      Issue No: Vol. 111, No. 15 (2014)
       
  • Centrioles regulate a checkpoint in the mouse [Developmental Biology]
    • Authors: Bazzi, H; Anderson, K. V.
      Pages: E1491 - E1500
      Abstract: Centrosomes are the microtubule-organizing centers of animal cells that organize interphase microtubules and mitotic spindles. Centrioles are the microtubule-based structures that organize centrosomes, and a defined set of proteins, including spindle assembly defective-4 (SAS4) (CPAP/CENPJ), is required for centriole biogenesis. The biological functions of centrioles and centrosomes vary among animals,...
      PubDate: 2014-04-15T09:08:15-07:00
      DOI: 10.1073/pnas.1400568111|hwp:master-id:pnas;1400568111
      Issue No: Vol. 111, No. 15 (2014)
       
  • Differential membrane PS recognition by Tim4 [Biophysics and Computational
           Biology]
    • Authors: Tietjen, G. T; Gong, Z, Chen, C.-H, Vargas, E, Crooks, J. E, Cao, K. D, Heffern, C. T. R, Henderson, J. M, Meron, M, Lin, B, Roux, B, Schlossman, M. L, Steck, T. L, Lee, K. Y. C, Adams, E. J.
      Pages: E1463 - E1472
      Abstract: Recognition of phosphatidylserine (PS) lipids exposed on the extracellular leaflet of plasma membranes is implicated in both apoptotic cell removal and immune regulation. The PS receptor T cell immunoglobulin and mucin-domain-containing molecule 4 (Tim4) regulates T-cell immunity via phagocytosis of both apoptotic (high PS exposure) and nonapoptotic (intermediate PS exposure)...
      PubDate: 2014-04-15T09:08:15-07:00
      DOI: 10.1073/pnas.1320174111|hwp:master-id:pnas;1320174111
      Issue No: Vol. 111, No. 15 (2014)
       
  • Conformational ensemble of a DNA bulge [Biophysics and Computational
           Biology]
    • Authors: Shi, X; Beauchamp, K. A, Harbury, P. B, Herschlag, D.
      Pages: E1473 - E1480
      Abstract: Direct experimental measurements of conformational ensembles are critical for understanding macromolecular function, but traditional biophysical methods do not directly report the solution ensemble of a macromolecule. Small-angle X-ray scattering interferometry has the potential to overcome this limitation by providing the instantaneous distance distribution between pairs of gold-nanocrystal probes conjugated to...
      PubDate: 2014-04-15T09:08:15-07:00
      DOI: 10.1073/pnas.1317032111|hwp:master-id:pnas;1317032111
      Issue No: Vol. 111, No. 15 (2014)
       
  • Protein aggregation inhibits endocytosis [Cell Biology]
    • Authors: Yu, A; Shibata, Y, Shah, B, Calamini, B, Lo, D. C, Morimoto, R. I.
      Pages: E1481 - E1490
      Abstract: Protein conformational diseases exhibit complex pathologies linked to numerous molecular defects. Aggregation of a disease-associated protein causes the misfolding and aggregation of other proteins, but how this interferes with diverse cellular pathways is unclear. Here, we show that aggregation of neurodegenerative disease-related proteins (polyglutamine, huntingtin, ataxin-1, and superoxide dismutase-1) inhibits...
      PubDate: 2014-04-15T09:08:15-07:00
      DOI: 10.1073/pnas.1321811111|hwp:master-id:pnas;1321811111
      Issue No: Vol. 111, No. 15 (2014)
       
  • Strong evidence for protein epistasis [Biological Sciences]
    • Authors: Pollock, D. D; Goldstein, R. A.
      Pages: E1450 - E1450
      Abstract: A recent paper by Ashenberg et al. (1) reports protein stability measurements and computational simulations that they claim contradict the results of our previous paper describing a “Stokes shift” in protein evolution (2). They make strong assertions that coevolutionary interactions among amino acids due to effects on stability do not...
      Keywords: Letters
      PubDate: 2014-04-15T09:08:15-07:00
      DOI: 10.1073/pnas.1401112111|hwp:master-id:pnas;1401112111
      Issue No: Vol. 111, No. 15 (2014)
       
  • CD133 and kidney repair [Biological Sciences]
    • Authors: Corbeil, D; Fargeas, C. A, Jaszai, J.
      Pages: E1451 - E1452
      Abstract: Kusaba et al. provide additional evidence using genetic lineage analysis that epithelial cell dedifferentiation is responsible for repair of proximal tubules after injury in mouse (1). These data challenge the hypothesis of the implication of scattered stem cells in such a process or highlight a potential distinction between rodent and...
      Keywords: Letters
      PubDate: 2014-04-15T09:08:15-07:00
      DOI: 10.1073/pnas.1400195111|hwp:master-id:pnas;1400195111
      Issue No: Vol. 111, No. 15 (2014)
       
  • Dedifferentiation and multipotency [Biological Sciences]
    • Authors: Kusaba, T; Humphreys, B. D.
      Pages: E1453 - E1453
      Abstract: We thank Corbeil et al. for raising important points (1) regarding our recent article (2) describing the role of epithelial dedifferentiation in kidney repair. We agree that the forward primer we used to detect CD133 mRNA is in fact not directed against the CD133 transcript. This error resulted from the...
      Keywords: Letters
      PubDate: 2014-04-15T09:08:15-07:00
      DOI: 10.1073/pnas.1401733111|hwp:master-id:pnas;1401733111
      Issue No: Vol. 111, No. 15 (2014)
       
  • Freeze-mediated expansion of mangroves [Biological Sciences]
    • Authors: Cavanaugh, K. C; Kellner, J. R, Forde, A. J, Gruner, D. S, Parker, J. D, Rodriguez, W, Feller, I. C.
      Pages: E1449 - E1449
      Abstract: Giri and Long (1) agree with our conclusion (2) that the expansion of mangroves from 1984 to 2011 near their range limit on the Atlantic coast of Florida is a threshold response to fewer days below −4 °C. However, they suggest that our conclusions would have been “substantially different” had...
      Keywords: Letters
      PubDate: 2014-04-15T09:08:15-07:00
      DOI: 10.1073/pnas.1401809111|hwp:master-id:pnas;1401809111
      Issue No: Vol. 111, No. 15 (2014)
       
  • Analysis of V. cholerae outer membrane vesicles [Microbiology]
    • Authors: Altindis, E; Fu, Y, Mekalanos, J. J.
      Pages: E1548 - E1556
      Abstract: Outer membrane vesicles (OMVs) produced by Gram-negative bacteria provide an interesting research material for defining cell-envelope proteins without experimental cell disruption. OMVs are also promising immunogenic platforms and may play important roles in bacterial survival and pathogenesis. We used in-solution trypsin digestion coupled to mass spectrometry to identify 90 proteins...
      PubDate: 2014-04-15T09:08:15-07:00
      DOI: 10.1073/pnas.1403683111|hwp:master-id:pnas;1403683111
      Issue No: Vol. 111, No. 15 (2014)
       
  • HIV-1 reactivation requires Hsp90 [Microbiology]
    • Authors: Anderson, I; Low, J. S, Weston, S, Weinberger, M, Zhyvoloup, A, Labokha, A. A, Corazza, G, Kitson, R. A, Moody, C. J, Marcello, A, Fassati, A.
      Pages: E1528 - E1537
      Abstract: Latency allows HIV-1 to persist in long-lived cellular reservoirs, preventing virus eradication. We have previously shown that the heat shock protein 90 (Hsp90) is required for HIV-1 gene expression and mediates greater HIV-1 replication in conditions of hyperthermia. Here we report that specific inhibitors of Hsp90 such as 17-(N-allylamino)-17-demethoxygeldanamycin and...
      PubDate: 2014-04-15T09:08:15-07:00
      DOI: 10.1073/pnas.1320178111|hwp:master-id:pnas;1320178111
      Issue No: Vol. 111, No. 15 (2014)
       
  • Lifespan extension in active, nondividing yeast [Microbiology]
    • Authors: Nagarajan, S; Kruckeberg, A. L, Schmidt, K. H, Kroll, E, Hamilton, M, McInnerney, K, Summers, R, Taylor, T, Rosenzweig, F.
      Pages: E1538 - E1547
      Abstract: Studies of replicative and chronological lifespan in Saccharomyces cerevisiae have advanced understanding of longevity in all eukaryotes. Chronological lifespan in this species is defined as the age-dependent viability of nondividing cells. To date this parameter has only been estimated under calorie restriction, mimicked by starvation. Because postmitotic cells in higher...
      PubDate: 2014-04-15T09:08:15-07:00
      DOI: 10.1073/pnas.1323918111|hwp:master-id:pnas;1323918111
      Issue No: Vol. 111, No. 15 (2014)
       
  • Mangrove reemergence in eastern Florida [Biological Sciences]
    • Authors: Giri, C. P; Long, J.
      Pages: E1447 - E1448
      Abstract: Cavanaugh et al. (1) report conclusive evidence of poleward expansion of mangroves at the northern limit of their historic range on the east coast of Florida and associate the expansion to a reduction in the frequency of extreme cold events. We agree with their assertion that mangrove expansion has occurred...
      Keywords: Letters
      PubDate: 2014-04-15T09:08:14-07:00
      DOI: 10.1073/pnas.1400687111|hwp:master-id:pnas;1400687111
      Issue No: Vol. 111, No. 15 (2014)
       
  • In This Issue [This Week in PNAS]
    • Pages: 5445 - 5446
      Abstract: Past climate change and marine carbon dioxide release The abrupt endings of glacial periods during the Pleistocene have led researchers to investigate the drivers of such ancient climate cycles. One hypothesis states that glacial melting may have interrupted global ocean circulation patterns in the North Atlantic, triggering a widespread release...
      PubDate: 2014-04-15T09:08:12-07:00
      DOI: 10.1073/iti1514111|hwp:resource-id:pnas;111/15/5445
      Issue No: Vol. 111, No. 15 (2014)
       
  • Supersized viruses [Science and Culture]
    • Authors: Ornes; S.
      Pages: 5447 - 5447
      Abstract: On February 22, festival-goers at Melbourne’s dusk-to-dawn White Night celebration lined up in droves outside the State Library of Victoria for an intimate evening with herpes. And they got it, in a big way: Bobbling around on the 40-meter-diameter central dome on the ceiling of the library’s La Trobe Reading...
      Keywords: Science and Culture
      PubDate: 2014-04-15T09:08:12-07:00
      DOI: 10.1073/pnas.1404827111|hwp:resource-id:pnas;111/15/5447
      Issue No: Vol. 111, No. 15 (2014)
       
  • Algal phytochromes [Plant Biology]
    • Authors: Forest; K. T.
      Pages: 5448 - 5449
      Abstract: The maritime palette is blue because light of this hue alone penetrates through the upper ocean. Longer wavelengths of visible light are absorbed by water; red light is found only within the top 5–20 m of coastal ocean, and yellow and green light are lost by ∼50 and ∼70 m,...
      PubDate: 2014-04-15T09:08:12-07:00
      DOI: 10.1073/pnas.1403530111|hwp:master-id:pnas;1403530111
      Issue No: Vol. 111, No. 15 (2014)
       
  • Predicting species vulnerability to climate change [Ecology]
    • Authors: Bernardo; J.
      Pages: 5450 - 5451
      Abstract: Cole (1) remarked [it is] “axiomatic that the reproductive potentials of existing species are related to their requirements for survival”; this logic applies to understanding species’ capacities to respond to anthropogenic climate change. Extant species reflect the ghost of environments past: species traits such as physiological performance and tolerance are...
      PubDate: 2014-04-15T09:08:12-07:00
      DOI: 10.1073/pnas.1404505111|hwp:master-id:pnas;1404505111
      Issue No: Vol. 111, No. 15 (2014)
       
  • Cryptic refuges for life during glaciation [Evolution]
    • Authors: Pointing, S. B; Bollard-Breen, B, Gillman, L. N.
      Pages: 5452 - 5453
      Abstract: A long-standing paradigm in ecology has been that contemporary biodiversity requires a diverse array of life to have survived through repeated Pleistocene glaciations when much of the higher latitudes on earth were covered in thick ice sheets. The notion that isolated pockets of ice-free land or “cryptic refugia” also persisted...
      PubDate: 2014-04-15T09:08:12-07:00
      DOI: 10.1073/pnas.1403594111|hwp:master-id:pnas;1403594111
      Issue No: Vol. 111, No. 15 (2014)
       
  • Imaging peptidoglycan with NIR fluorogenic azides [Biochemistry]
    • Authors: Shieh, P; Siegrist, M. S, Cullen, A. J, Bertozzi, C. R.
      Pages: 5456 - 5461
      Abstract: Fluorescent probes designed for activation by bioorthogonal chemistry have enabled the visualization of biomolecules in living systems. Such activatable probes with near-infrared (NIR) emission would be ideal for in vivo imaging but have proven difficult to engineer. We present the development of NIR fluorogenic azide probes based on the Si-rhodamine...
      PubDate: 2014-04-15T09:08:12-07:00
      DOI: 10.1073/pnas.1322727111|hwp:master-id:pnas;1322727111
      Issue No: Vol. 111, No. 15 (2014)
       
  • Methanogenic burst in the end-Permian carbon cycle [Evolution]
    • Authors: Rothman, D. H; Fournier, G. P, French, K. L, Alm, E. J, Boyle, E. A, Cao, C, Summons, R. E.
      Pages: 5462 - 5467
      Abstract: The end-Permian extinction is associated with a mysterious disruption to Earth’s carbon cycle. Here we identify causal mechanisms via three observations. First, we show that geochemical signals indicate superexponential growth of the marine inorganic carbon reservoir, coincident with the extinction and consistent with the expansion of a new microbial metabolic...
      PubDate: 2014-04-15T09:08:12-07:00
      DOI: 10.1073/pnas.1318106111|hwp:master-id:pnas;1318106111
      Issue No: Vol. 111, No. 15 (2014)
       
  • Dynamic Archean sulfur cycle [Evolution]
    • Authors: Fischer, W. W; Fike, D. A, Johnson, J. E, Raub, T. D, Guan, Y, Kirschvink, J. L, Eiler, J. M.
      Pages: 5468 - 5473
      Abstract: Many aspects of Earth’s early sulfur cycle, from the origin of mass-anomalous fractionations to the degree of biological participation, remain poorly understood—in part due to complications from postdepositional diagenetic and metamorphic processes. Using a combination of scanning high-resolution magnetic superconducting quantum interference device (SQUID) microscopy and secondary ion mass spectrometry...
      PubDate: 2014-04-15T09:08:13-07:00
      DOI: 10.1073/pnas.1322577111|hwp:master-id:pnas;1322577111
      Issue No: Vol. 111, No. 15 (2014)
       
  • Methanethiol in hydrothermal fluids [Earth, Atmospheric, and Planetary
           Sciences]
    • Authors: Reeves, E. P; McDermott, J. M, Seewald, J. S.
      Pages: 5474 - 5479
      Abstract: Simple alkyl thiols such as methanethiol (CH3SH) are widely speculated to form in seafloor hot spring fluids. Putative CH3SH synthesis by abiotic (nonbiological) reduction of inorganic carbon (CO2 or CO) has been invoked as an initiation reaction for the emergence of protometabolism and microbial life in primordial hydrothermal settings. Thiols...
      PubDate: 2014-04-15T09:08:13-07:00
      DOI: 10.1073/pnas.1400643111|hwp:master-id:pnas;1400643111
      Issue No: Vol. 111, No. 15 (2014)
       
  • Bipolar seesaw in Atlantic deep-water ventilation [Earth, Atmospheric, and
           Planetary Sciences]
    • Authors: Skinner, L. C; Waelbroeck, C, Scrivner, A. E, Fallon, S. J.
      Pages: 5480 - 5484
      Abstract: Recent theories for glacial–interglacial climate transitions call on millennial climate perturbations that purged the deep sea of sequestered carbon dioxide via a “bipolar ventilation seesaw.” However, the viability of this hypothesis has been contested, and robust evidence in its support is lacking. Here we present a record of North Atlantic...
      PubDate: 2014-04-15T09:08:13-07:00
      DOI: 10.1073/pnas.1400668111|hwp:master-id:pnas;1400668111
      Issue No: Vol. 111, No. 15 (2014)
       
  • Dangers and constructions in models of randomness [Mathematics]
    • Authors: Pincus, S; Singer, B. H.
      Pages: 5485 - 5490
      Abstract: The certification, construction, and delineation of individual, infinite-length “random” sequences have been longstanding yet incompletely resolved problems. We address this topic via the study of normal numbers, which often have been viewed as reasonable proxies for randomness, given their limiting equidistribution of subblocks of all lengths. However, limitations arise within...
      PubDate: 2014-04-15T09:08:13-07:00
      DOI: 10.1073/pnas.1402621111|hwp:master-id:pnas;1402621111
      Issue No: Vol. 111, No. 15 (2014)
       
  • Lattice dynamics by ultrafast Kikuchi diffraction [Physics]
    • Authors: Liang, W; Vanacore, G. M, Zewail, A. H.
      Pages: 5491 - 5496
      Abstract: In materials, the nature of the strain–stress relationship, which is fundamental to their properties, is determined by both the linear and nonlinear elastic responses. Whereas the linear response can be measured by various techniques, the nonlinear behavior is nontrivial to probe and to reveal its nature. Here, we report the...
      PubDate: 2014-04-15T09:08:13-07:00
      DOI: 10.1073/pnas.1404101111|hwp:master-id:pnas;1404101111
      Issue No: Vol. 111, No. 15 (2014)
       
  • Americans are ill prepared for the ACA [Economic Sciences]
    • Authors: Barcellos, S. H; Wuppermann, A. C, Carman, K. G, Bauhoff, S, McFadden, D. L, Kapteyn, A, Winter, J. K, Goldman, D.
      Pages: 5497 - 5502
      Abstract: This paper investigates whether individuals are sufficiently informed to make reasonable choices in the health insurance exchanges established by the Affordable Care Act (ACA). We document knowledge of health reform, health insurance literacy, and expected changes in healthcare using a nationally representative survey of the US population in the 5...
      PubDate: 2014-04-15T09:08:13-07:00
      DOI: 10.1073/pnas.1320488111|hwp:master-id:pnas;1320488111
      Issue No: Vol. 111, No. 15 (2014)
       
  • Oxytocin promotes group-serving dishonesty [Psychological and Cognitive
           Sciences]
    • Authors: Shalvi, S; De Dreu, C. K. W.
      Pages: 5503 - 5507
      Abstract: To protect and promote the well-being of others, humans may bend the truth and behave unethically. Here we link such tendencies to oxytocin, a neuropeptide known to promote affiliation and cooperation with others. Using a simple coin-toss prediction task in which participants could dishonestly report their performance levels to benefit...
      PubDate: 2014-04-15T09:08:13-07:00
      DOI: 10.1073/pnas.1400724111|hwp:master-id:pnas;1400724111
      Issue No: Vol. 111, No. 15 (2014)
       
  • Biomimetic engineered skeletal muscle [Applied Biological Sciences]
    • Authors: Juhas, M; Engelmayr, G. C, Fontanella, A. N, Palmer, G. M, Bursac, N.
      Pages: 5508 - 5513
      Abstract: Tissue-engineered skeletal muscle can serve as a physiological model of natural muscle and a potential therapeutic vehicle for rapid repair of severe muscle loss and injury. Here, we describe a platform for engineering and testing highly functional biomimetic muscle tissues with a resident satellite cell niche and capacity for robust...
      PubDate: 2014-04-15T09:08:13-07:00
      DOI: 10.1073/pnas.1402723111|hwp:master-id:pnas;1402723111
      Issue No: Vol. 111, No. 15 (2014)
       
  • Docking protein mediated VEGF receptor signaling [Biochemistry]
    • Authors: Chen, P.-Y; Qin, L, Zhuang, Z. W, Tellides, G, Lax, I, Schlessinger, J, Simons, M.
      Pages: 5514 - 5519
      Abstract: Vascular endothelial growth factors (VEGFs) signal via their cognate receptor tyrosine kinases designated VEGFR1-3. We report that the docking protein fibroblast growth factor receptor substrate 2 (FRS2α) plays a critical role in cell signaling via these receptors. In vitro FRS2α regulates VEGF-A and VEGF-C–dependent activation of extracellular signal-regulated receptor kinase...
      PubDate: 2014-04-15T09:08:13-07:00
      DOI: 10.1073/pnas.1404545111|hwp:master-id:pnas;1404545111
      Issue No: Vol. 111, No. 15 (2014)
       
  • Regulation of FGF23 by Fam20C phosphorylation [Biochemistry]
    • Authors: Tagliabracci, V. S; Engel, J. L, Wiley, S. E, Xiao, J, Gonzalez, D. J, Nidumanda Appaiah, H, Koller, A, Nizet, V, White, K. E, Dixon, J. E.
      Pages: 5520 - 5525
      Abstract: The family with sequence similarity 20, member C (Fam20C) has recently been identified as the Golgi casein kinase. Fam20C phosphorylates secreted proteins on Ser-x-Glu/pSer motifs and loss-of-function mutations in the kinase cause Raine syndrome, an often-fatal osteosclerotic bone dysplasia. Fam20C is potentially an upstream regulator of the phosphate-regulating hormone fibroblast...
      PubDate: 2014-04-15T09:08:13-07:00
      DOI: 10.1073/pnas.1402218111|hwp:master-id:pnas;1402218111
      Issue No: Vol. 111, No. 15 (2014)
       
  • Chronology in lesion tolerance [Biochemistry]
    • Authors: Naiman, K; Philippin, G, Fuchs, R. P, Pages, V.
      Pages: 5526 - 5531
      Abstract: The encounter of a replication fork with a blocking DNA lesion is a common event that cells need to address properly to preserve genome integrity. Cells possess two main strategies to tolerate unrepaired lesions: potentially mutagenic translesion synthesis (TLS) and nonmutagenic damage avoidance (DA). Little is known about the partitioning...
      PubDate: 2014-04-15T09:08:13-07:00
      DOI: 10.1073/pnas.1321008111|hwp:master-id:pnas;1321008111
      Issue No: Vol. 111, No. 15 (2014)
       
  • Water drives the 20S proteasome gating reaction [Chemistry]
    • Authors: Latham, M. P; Sekhar, A, Kay, L. E.
      Pages: 5532 - 5537
      Abstract: The 20S core particle proteasome is a molecular machine playing an important role in cellular function by degrading protein substrates that no longer are required or that have become damaged. Regulation of proteasome activity occurs, in part, through a gating mechanism controlling the sizes of pores at the top and...
      PubDate: 2014-04-15T09:08:13-07:00
      DOI: 10.1073/pnas.1322079111|hwp:master-id:pnas;1322079111
      Issue No: Vol. 111, No. 15 (2014)
       
  • smFRET study on programmed -1 frameshifting [Biophysics and Computational
           Biology]
    • Authors: Kim, H.-K; Liu, F, Fei, J, Bustamante, C, Gonzalez, R. L, Tinoco, I.
      Pages: 5538 - 5543
      Abstract: Ribosomal frameshifting occurs when a ribosome slips a few nucleotides on an mRNA and generates a new sequence of amino acids. Programmed −1 ribosomal frameshifting (−1PRF) is used in various systems to express two or more proteins from a single mRNA at precisely regulated levels. We used single-molecule fluorescence resonance...
      PubDate: 2014-04-15T09:08:13-07:00
      DOI: 10.1073/pnas.1403457111|hwp:master-id:pnas;1403457111
      Issue No: Vol. 111, No. 15 (2014)
       
  • Conformational landscape of the 26S proteasome [Biophysics and
           Computational Biology]
    • Authors: Unverdorben, P; Beck, F, Śledź, P, Schweitzer, A, Pfeifer, G, Plitzko, J. M, Baumeister, W, Forster, F.
      Pages: 5544 - 5549
      Abstract: The 26S proteasome is a 2.5 MDa molecular machine that executes the degradation of substrates of the ubiquitin–proteasome pathway. The molecular architecture of the 26S proteasome was recently established by cryo-EM approaches. For a detailed understanding of the sequence of events from the initial binding of polyubiquitylated substrates to the...
      PubDate: 2014-04-15T09:08:13-07:00
      DOI: 10.1073/pnas.1403409111|hwp:master-id:pnas;1403409111
      Issue No: Vol. 111, No. 15 (2014)
       
  • Crosstalk in two-component signaling [Biophysics and Computational
           Biology]
    • Authors: Rowland, M. A; Deeds, E. J.
      Pages: 5550 - 5555
      Abstract: Two-component signaling (TCS) serves as the dominant signaling modality in bacteria. A typical pathway includes a sensor histidine kinase (HK) that phosphorylates a response regulator (RR), modulating its activity in response to an incoming signal. Most HKs are bifunctional, acting as both kinase and phosphatase for their substrates. Unlike eukaryotic...
      PubDate: 2014-04-15T09:08:13-07:00
      DOI: 10.1073/pnas.1317178111|hwp:master-id:pnas;1317178111
      Issue No: Vol. 111, No. 15 (2014)
       
  • Electron transport via cytochrome c [Biophysics and Computational Biology]
    • Authors: Amdursky, N; Ferber, D, Bortolotti, C. A, Dolgikh, D. A, Chertkova, R. V, Pecht, I, Sheves, M, Cahen, D.
      Pages: 5556 - 5561
      Abstract: Electronic coupling to electrodes, Γ, as well as that across the examined molecules, H, is critical for solid-state electron transport (ETp) across proteins. Assessing the importance of each of these couplings helps to understand the mechanism of electron flow across molecules. We provide here experimental evidence for the importance of...
      PubDate: 2014-04-15T09:08:13-07:00
      DOI: 10.1073/pnas.1319351111|hwp:master-id:pnas;1319351111
      Issue No: Vol. 111, No. 15 (2014)
       
  • Dimeric kinesin-3 motors are superprocessive [Biophysics and Computational
           Biology]
    • Authors: Soppina, V; Norris, S. R, Dizaji, A. S, Kortus, M, Veatch, S, Peckham, M, Verhey, K. J.
      Pages: 5562 - 5567
      Abstract: The kinesin-3 family is one of the largest among the kinesin superfamily and its members play important roles in a wide range of cellular transport activities, yet the molecular mechanisms of kinesin-3 regulation and cargo transport are largely unknown. We performed a comprehensive analysis of mammalian kinesin-3 motors from three...
      PubDate: 2014-04-15T09:08:13-07:00
      DOI: 10.1073/pnas.1400759111|hwp:master-id:pnas;1400759111
      Issue No: Vol. 111, No. 15 (2014)
       
  • Proline switch modulates force sensing of filamin [Biophysics and
           Computational Biology]
    • Authors: Rognoni, L; Most, T, Žoldak, G, Rief, M.
      Pages: 5568 - 5573
      Abstract: Proline switches, controlled by cis–trans isomerization, have emerged as a particularly effective regulatory mechanism in a wide range of biological processes. In this study, we use single-molecule mechanical measurements to develop a full kinetic and energetic description of a highly conserved proline switch in the force-sensing domain 20 of human...
      PubDate: 2014-04-15T09:08:13-07:00
      DOI: 10.1073/pnas.1319448111|hwp:master-id:pnas;1319448111
      Issue No: Vol. 111, No. 15 (2014)
       
  • SUMO regulates cell differentiation [Cell Biology]
    • Authors: Gong, L; Ji, W.-K, Hu, X.-H, Hu, W.-F, Tang, X.-C, Huang, Z.-X, Li, L, Liu, M, Xiang, S.-H, Wu, E, Woodward, Z, Liu, Y.-Z, Nguyen, Q. D, Li, D. W.-C.
      Pages: 5574 - 5579
      Abstract: The mammalian small ubiquitin-like modifiers (SUMOs) are actively involved in regulating differentiation of different cell types. However, the functional differences between SUMO isoforms and their mechanisms of action remain largely unknown. Using the ocular lens as a model system, we demonstrate that different SUMOs display distinct functions in regulating differentiation...
      PubDate: 2014-04-15T09:08:13-07:00
      DOI: 10.1073/pnas.1315034111|hwp:master-id:pnas;1315034111
      Issue No: Vol. 111, No. 15 (2014)
       
  • Combined hydrogels for pluripotent stem cells [Cell Biology]
    • Authors: Dixon, J. E; Shah, D. A, Rogers, C, Hall, S, Weston, N, Parmenter, C. D. J, McNally, D, Denning, C, Shakesheff, K. M.
      Pages: 5580 - 5585
      Abstract: The ability of materials to define the architecture and microenvironment experienced by cells provides new opportunities to direct the fate of human pluripotent stem cells (HPSCs) [Robinton DA, Daley GQ (2012) Nature 481(7381):295–305]. However, the conditions required for self-renewal vs. differentiation of HPSCs are different, and a single system that...
      PubDate: 2014-04-15T09:08:13-07:00
      DOI: 10.1073/pnas.1319685111|hwp:master-id:pnas;1319685111
      Issue No: Vol. 111, No. 15 (2014)
       
  • Spatial constraints control growth in tissues [Developmental Biology]
    • Authors: Streichan, S. J; Hoerner, C. R, Schneidt, T, Holzer, D, Hufnagel, L.
      Pages: 5586 - 5591
      Abstract: Control of cell proliferation is a fundamental aspect of tissue formation in development and regeneration. Cells experience various spatial and mechanical constraints depending on their environmental context in the body, but we do not fully understand if and how such constraints influence cell cycle progression and thereby proliferation patterns in...
      PubDate: 2014-04-15T09:08:13-07:00
      DOI: 10.1073/pnas.1323016111|hwp:master-id:pnas;1323016111
      Issue No: Vol. 111, No. 15 (2014)
       
  • Temperature control of O-GlcNAc in poikilotherms [Developmental Biology]
    • Authors: Radermacher, P. T; Myachina, F, Bosshardt, F, Pandey, R, Mariappa, D, Muller, H.– A. J, Lehner, C. F.
      Pages: 5592 - 5597
      Abstract: Effects of temperature on biological processes are complex. Diffusion is less affected than the diverse enzymatic reactions that have distinct individual temperature profiles. Hence thermal fluctuations pose a formidable challenge to ectothermic organisms in which body temperature is largely dictated by the ambient temperature. How cells in ectotherms cope with...
      PubDate: 2014-04-15T09:08:13-07:00
      DOI: 10.1073/pnas.1322396111|hwp:master-id:pnas;1322396111
      Issue No: Vol. 111, No. 15 (2014)
       
  • Olive bioeconomics under climate warming [Economic Sciences]
    • Authors: Ponti, L; Gutierrez, A. P, Ruti, P. M, Dell'Aquila, A.
      Pages: 5598 - 5603
      Abstract: The Mediterranean Basin is a climate and biodiversity hot spot, and climate change threatens agro-ecosystems such as olive, an ancient drought-tolerant crop of considerable ecological and socioeconomic importance. Climate change will impact the interactions of olive and the obligate olive fruit fly (Bactrocera oleae), and alter the economics of olive...
      PubDate: 2014-04-15T09:08:13-07:00
      DOI: 10.1073/pnas.1314437111|hwp:master-id:pnas;1314437111
      Issue No: Vol. 111, No. 15 (2014)
       
  • Amazonian functional assembly [Ecology]
    • Authors: Asner, G. P; Martin, R. E, Tupayachi, R, Anderson, C. B, Sinca, F, Carranza–Jimenez, L, Martinez, P.
      Pages: 5604 - 5609
      Abstract: Patterns of tropical forest functional diversity express processes of ecological assembly at multiple geographic scales and aid in predicting ecological responses to environmental change. Tree canopy chemistry underpins forest functional diversity, but the interactive role of phylogeny and environment in determining the chemical traits of tropical trees is poorly known....
      PubDate: 2014-04-15T09:08:13-07:00
      DOI: 10.1073/pnas.1401181111|hwp:master-id:pnas;1401181111
      Issue No: Vol. 111, No. 15 (2014)
       
  • Behavior thwarts thermal danger [Ecology]
    • Authors: Sunday, J. M; Bates, A. E, Kearney, M. R, Colwell, R. K, Dulvy, N. K, Longino, J. T, Huey, R. B.
      Pages: 5610 - 5615
      Abstract: Physiological thermal-tolerance limits of terrestrial ectotherms often exceed local air temperatures, implying a high degree of thermal safety (an excess of warm or cold thermal tolerance). However, air temperatures can be very different from the equilibrium body temperature of an individual ectotherm. Here, we compile thermal-tolerance limits of ectotherms across...
      PubDate: 2014-04-15T09:08:13-07:00
      DOI: 10.1073/pnas.1316145111|hwp:master-id:pnas;1316145111
      Issue No: Vol. 111, No. 15 (2014)
       
  • Traits predict tropical forest dynamics [Ecology]
    • Authors: Lasky, J. R; Uriarte, M, Boukili, V. K, Chazdon, R. L.
      Pages: 5616 - 5621
      Abstract: Interspecific differences in relative fitness can cause local dominance by a single species. However, stabilizing interspecific niche differences can promote local diversity. Understanding these mechanisms requires that we simultaneously quantify their effects on demography and link these effects to community dynamics. Successional forests are ideal systems for testing assembly theory...
      PubDate: 2014-04-15T09:08:14-07:00
      DOI: 10.1073/pnas.1319342111|hwp:master-id:pnas;1319342111
      Issue No: Vol. 111, No. 15 (2014)
       
  • Ecological differentiation in marine bacteria [Ecology]
    • Authors: Yawata, Y; Cordero, O. X, Menolascina, F, Hehemann, J.-H, Polz, M. F, Stocker, R.
      Pages: 5622 - 5627
      Abstract: Although competition–dispersal tradeoffs are commonly invoked to explain species coexistence for animals and plants in spatially structured environments, such mechanisms for coexistence remain unknown for microorganisms. Here we show that two recently speciated marine bacterioplankton populations pursue different behavioral strategies to exploit nutrient particles in adaptation to the landscape of...
      PubDate: 2014-04-15T09:08:14-07:00
      DOI: 10.1073/pnas.1318943111|hwp:master-id:pnas;1318943111
      Issue No: Vol. 111, No. 15 (2014)
       
  • Deoxygenation of the Baltic Sea [Ecology]
    • Authors: Carstensen, J; Andersen, J. H, Gustafsson, B. G, Conley, D. J.
      Pages: 5628 - 5633
      Abstract: Deoxygenation is a global problem in coastal and open regions of the ocean, and has led to expanding areas of oxygen minimum zones and coastal hypoxia. The recent expansion of hypoxia in coastal ecosystems has been primarily attributed to global warming and enhanced nutrient input from land and atmosphere. The...
      PubDate: 2014-04-15T09:08:14-07:00
      DOI: 10.1073/pnas.1323156111|hwp:master-id:pnas;1323156111
      Issue No: Vol. 111, No. 15 (2014)
       
  • Geothermal refugia [Evolution]
    • Authors: Fraser, C. I; Terauds, A, Smellie, J, Convey, P, Chown, S. L.
      Pages: 5634 - 5639
      Abstract: Climate change has played a critical role in the evolution and structure of Earth’s biodiversity. Geothermal activity, which can maintain ice-free terrain in glaciated regions, provides a tantalizing solution to the question of how diverse life can survive glaciations. No comprehensive assessment of this “geothermal glacial refugia” hypothesis has yet...
      PubDate: 2014-04-15T09:08:14-07:00
      DOI: 10.1073/pnas.1321437111|hwp:master-id:pnas;1321437111
      Issue No: Vol. 111, No. 15 (2014)
       
  • From bad ribosomes to cancer [Genetics]
    • Authors: Sulima, S. O; Patchett, S, Advani, V. M, De Keersmaecker, K, Johnson, A. W, Dinman, J. D.
      Pages: 5640 - 5645
      Abstract: Ribosomopathies are a class of diseases caused by mutations that affect the biosynthesis and/or functionality of the ribosome. Although they initially present as hypoproliferative disorders, such as anemia, patients have elevated risk of hyperproliferative disease (cancer) by midlife. Here, this paradox is explored using the rpL10-R98S (uL16-R98S) mutant yeast model...
      PubDate: 2014-04-15T09:08:14-07:00
      DOI: 10.1073/pnas.1400247111|hwp:master-id:pnas;1400247111
      Issue No: Vol. 111, No. 15 (2014)
       
  • Role of MEX3C in antiviral immune responses [Immunology]
    • Authors: Kuniyoshi, K; Takeuchi, O, Pandey, S, Satoh, T, Iwasaki, H, Akira, S, Kawai, T.
      Pages: 5646 - 5651
      Abstract: The RIG-I–like receptors, retinoic acid inducible gene-1 (RIG-I), melanoma differentiation-associated protein 5, and laboratory of genetics and physiology-2, are cytoplasmic sensors for RNA viruses that mediate the antiviral innate immune responses. We demonstrate that really interesting new gene-finger domain- and K homology domain-containing MEX3C regulates RIG-I function. MEX3C colocalizes with...
      PubDate: 2014-04-15T09:08:14-07:00
      DOI: 10.1073/pnas.1401674111|hwp:master-id:pnas;1401674111
      Issue No: Vol. 111, No. 15 (2014)
       
  • GC interactions are required for TCR revision [Immunology]
    • Authors: Higdon, L. E; Deets, K. A, Friesen, T. J, Sze, K.-Y, Fink, P. J.
      Pages: 5652 - 5657
      Abstract: Peripheral CD4 T cells in Vβ5 transgenic (Tg) C57BL/6J mice undergo tolerance to an endogenous superantigen encoded by mouse mammary tumor virus 8 (Mtv-8) by either deletion or T-cell receptor (TCR) revision. Revision is a process by which surface expression of the Vβ5+ TCR is down-regulated in response to Mtv-8...
      PubDate: 2014-04-15T09:08:14-07:00
      DOI: 10.1073/pnas.1321803111|hwp:master-id:pnas;1321803111
      Issue No: Vol. 111, No. 15 (2014)
       
  • Pre-TCR enforces {gamma}{delta}-fate with weak {gamma}{delta}-TCR signals
           [Immunology]
    • Authors: Zarin, P; Wong, G. W, Mohtashami, M, Wiest, D. L, Zuniga–Pflucker, J. C.
      Pages: 5658 - 5663
      Abstract: Developing thymocytes bifurcate from a bipotent precursor into αβ- or γδ-lineage T cells. Considering this common origin and the fact that the T-cell receptor (TCR) β-, γ-, and δ-chains simultaneously rearrange at the double negative (DN) stage of development, the possibility exists that a given DN cell can express and...
      PubDate: 2014-04-15T09:08:14-07:00
      DOI: 10.1073/pnas.1312872111|hwp:master-id:pnas;1312872111
      Issue No: Vol. 111, No. 15 (2014)
       
  • IL-17 promotes tumor in early stage of lung cancer [Immunology]
    • Authors: Chang, S. H; Mirabolfathinejad, S. G, Katta, H, Cumpian, A. M, Gong, L, Caetano, M. S, Moghaddam, S. J, Dong, C.
      Pages: 5664 - 5669
      Abstract: Lung cancer development is associated with extensive pulmonary inflammation. In addition, the linkage between chronic obstructive pulmonary disease (COPD) and lung cancer has been demonstrated in population-based studies. IL-17–producing CD4 helper T cells (Th17 cells) play a critical role in promoting chronic tissue inflammation. Although Th17 cells are found in...
      PubDate: 2014-04-15T09:08:14-07:00
      DOI: 10.1073/pnas.1319051111|hwp:master-id:pnas;1319051111
      Issue No: Vol. 111, No. 15 (2014)
       
  • Gentamicin reveals cryptic epitopes in the 3' UTR [Immunology]
    • Authors: Goodenough, E; Robinson, T. M, Zook, M. B, Flanigan, K. M, Atkins, J. F, Howard, M. T, Eisenlohr, L. C.
      Pages: 5670 - 5675
      Abstract: Aminoglycosides have been proposed as therapies for genetic disorders caused by nonsense mutations, because of their capacity to enhance translational read-through of premature termination codons (PTCs), thereby permitting expression of functional full-length protein. However, a potential consequence of this strategy is the development of an autoimmune response to HLA-presented epitopes...
      PubDate: 2014-04-15T09:08:14-07:00
      DOI: 10.1073/pnas.1402670111|hwp:master-id:pnas;1402670111
      Issue No: Vol. 111, No. 15 (2014)
       
  • Toward a universal vaccine for influenza [Medical Sciences]
    • Authors: Valkenburg, S. A; Li, O. T. W, Mak, P. W. Y, Mok, C. K. P, Nicholls, J. M, Guan, Y, Waldmann, T. A, Peiris, J. S. M, Perera, L. P, Poon, L. L. M.
      Pages: 5676 - 5681
      Abstract: Current influenza vaccines are ineffective against novel viruses and the source or the strain of the next outbreak of influenza is unpredictable; therefore, establishing universal immunity by vaccination to limit the impact of influenza remains a high priority. To meet this challenge, a novel vaccine has been developed using the...
      PubDate: 2014-04-15T09:08:14-07:00
      DOI: 10.1073/pnas.1403684111|hwp:master-id:pnas;1403684111
      Issue No: Vol. 111, No. 15 (2014)
       
  • Bcl2L13 inhibits ceramide synthase activity [Medical Sciences]
    • Authors: Jensen, S. A; Calvert, A. E, Volpert, G, Kouri, F. M, Hurley, L. A, Luciano, J. P, Wu, Y, Chalastanis, A, Futerman, A. H, Stegh, A. H.
      Pages: 5682 - 5687
      Abstract: Therapy resistance is a major limitation to the successful treatment of cancer. Here, we identify Bcl2-like 13 (Bcl2L13), an atypical member of the Bcl-2 family, as a therapy susceptibility gene with elevated expression in solid and blood cancers, including glioblastoma (GBM). We demonstrate that mitochondria-associated Bcl2L13 inhibits apoptosis induced by...
      PubDate: 2014-04-15T09:08:14-07:00
      DOI: 10.1073/pnas.1316700111|hwp:master-id:pnas;1316700111
      Issue No: Vol. 111, No. 15 (2014)
       
  • Angucyclines as signals [Microbiology]
    • Authors: Wang, W; Ji, J, Li, X, Wang, J, Li, S, Pan, G, Fan, K, Yang, K.
      Pages: 5688 - 5693
      Abstract: The angucycline antibiotic jadomycin B (JdB) produced by Streptomyces venezuelae has been found here to induce complex survival responses in Streptomyces coelicolor at subinhibitory concentration. The receptor for JdB was identified as a “pseudo” gamma-butyrolactone receptor, ScbR2, which was shown to bind two previously unidentified target promoters, those of redD...
      PubDate: 2014-04-15T09:08:14-07:00
      DOI: 10.1073/pnas.1324253111|hwp:master-id:pnas;1324253111
      Issue No: Vol. 111, No. 15 (2014)
       
  • Global dissemination of E. coli ST131 [Microbiology]
    • Authors: Petty, N. K; Ben Zakour, N. L, Stanton–Cook, M, Skippington, E, Totsika, M, Forde, B. M, Phan, M.–D, Gomes Moriel, D, Peters, K. M, Davies, M, Rogers, B. A, Dougan, G, Rodriguez–Bano, J, Pascual, A, Pitout, J. D. D, Upton, M, Paterson, D. L, Walsh, T. R, Schembri, M. A, Beatson, S. A.
      Pages: 5694 - 5699
      Abstract: Escherichia coli sequence type 131 (ST131) is a globally disseminated, multidrug resistant (MDR) clone responsible for a high proportion of urinary tract and bloodstream infections. The rapid emergence and successful spread of E. coli ST131 is strongly associated with several factors, including resistance to fluoroquinolones, high virulence gene content, the...
      PubDate: 2014-04-15T09:08:14-07:00
      DOI: 10.1073/pnas.1322678111|hwp:master-id:pnas;1322678111
      Issue No: Vol. 111, No. 15 (2014)
       
  • A mechanism for integral feedback [Engineering]
    • Authors: Schnell, B; Weir, P. T, Roth, E, Fairhall, A. L, Dickinson, M. H.
      Pages: 5700 - 5705
      Abstract: Sensory feedback is a ubiquitous feature of guidance systems in both animals and engineered vehicles. For example, a common strategy for moving along a straight path is to turn such that the measured rate of rotation is zero. This task can be accomplished by using a feedback signal that is...
      PubDate: 2014-04-15T09:08:14-07:00
      DOI: 10.1073/pnas.1400698111|hwp:master-id:pnas;1400698111
      Issue No: Vol. 111, No. 15 (2014)
       
  • Huntingtin ubiquitination modulated by Ube3a [Neuroscience]
    • Authors: Bhat, K. P; Yan, S, Wang, C.-E, Li, S, Li, X.-J.
      Pages: 5706 - 5711
      Abstract: Ubiquitination of misfolded proteins, a common feature of many neurodegenerative diseases, is mediated by different lysine (K) residues in ubiquitin and alters the levels of toxic proteins. In Huntington disease, polyglutamine expansion causes N-terminal huntingtin (Htt) to misfold, inducing neurodegeneration. Here we report that shorter N-terminal Htt fragments are more...
      PubDate: 2014-04-15T09:08:14-07:00
      DOI: 10.1073/pnas.1402215111|hwp:master-id:pnas;1402215111
      Issue No: Vol. 111, No. 15 (2014)
       
  • Functional evolution of Erg potassium channels [Neuroscience]
    • Authors: Martinson, A. S; van Rossum, D. B, Diatta, F. H, Layden, M. J, Rhodes, S. A, Martindale, M. Q, Jegla, T.
      Pages: 5712 - 5717
      Abstract: Mammalian Ether-a-go-go related gene (Erg) family voltage-gated K+ channels possess an unusual gating phenotype that specializes them for a role in delayed repolarization. Mammalian Erg currents rectify during depolarization due to rapid, voltage-dependent inactivation, but rebound during repolarization due to a combination of rapid recovery from inactivation and slow deactivation....
      PubDate: 2014-04-15T09:08:14-07:00
      DOI: 10.1073/pnas.1321716111|hwp:master-id:pnas;1321716111
      Issue No: Vol. 111, No. 15 (2014)
       
  • Merged hand/mouth neural representations in humans [Neuroscience]
    • Authors: Desmurget, M; Richard, N, Harquel, S, Baraduc, P, Szathmari, A, Mottolese, C, Sirigu, A.
      Pages: 5718 - 5722
      Abstract: Complex motor responses are often thought to result from the combination of elemental movements represented at different neural sites. However, in monkeys, evidence indicates that some behaviors with critical ethological value, such as self-feeding, are represented as motor primitives in the precentral gyrus (PrG). In humans, such primitives have not...
      PubDate: 2014-04-15T09:08:14-07:00
      DOI: 10.1073/pnas.1321909111|hwp:master-id:pnas;1321909111
      Issue No: Vol. 111, No. 15 (2014)
       
  • Microtubule binding unique to dystrophin [Physiology]
    • Authors: Belanto, J. J; Mader, T. L, Eckhoff, M. D, Strandjord, D. M, Banks, G. B, Gardner, M. K, Lowe, D. A, Ervasti, J. M.
      Pages: 5723 - 5728
      Abstract: Dystrophin and utrophin are highly similar proteins that both link cortical actin filaments with a complex of sarcolemmal glycoproteins, yet localize to different subcellular domains within normal muscle cells. In mdx mice and Duchenne muscular dystrophy patients, dystrophin is lacking and utrophin is consequently up-regulated and redistributed to locations normally...
      PubDate: 2014-04-15T09:08:14-07:00
      DOI: 10.1073/pnas.1323842111|hwp:master-id:pnas;1323842111
      Issue No: Vol. 111, No. 15 (2014)
       
  • Activin signaling and metabolism [Physiology]
    • Authors: Ghosh, A. C; O'Connor, M. B.
      Pages: 5729 - 5734
      Abstract: The ability to maintain cellular and physiological metabolic homeostasis is key for the survival of multicellular organisms in changing environmental conditions. However, our understanding of extracellular signaling pathways that modulate metabolic processes remains limited. In this study we show that the Activin-like ligand Dawdle (Daw) is a major regulator of...
      PubDate: 2014-04-15T09:08:14-07:00
      DOI: 10.1073/pnas.1319116111|hwp:master-id:pnas;1319116111
      Issue No: Vol. 111, No. 15 (2014)
       
  • FSH rerouting and ovarian function [Physiology]
    • Authors: Wang, H; Larson, M, Jablonka-Shariff, A, Pearl, C. A, Miller, W. L, Conn, P. M, Boime, I, Kumar, T. R.
      Pages: 5735 - 5740
      Abstract: FSH and luteinizing hormone (LH) are secreted constitutively or in pulses, respectively, from pituitary gonadotropes in many vertebrates, and regulate ovarian function. The molecular basis for this evolutionarily conserved gonadotropin-specific secretion pattern is not understood. Here, we show that the carboxyterminal heptapeptide in LH is a gonadotropin-sorting determinant in vivo...
      PubDate: 2014-04-15T09:08:14-07:00
      DOI: 10.1073/pnas.1321404111|hwp:master-id:pnas;1321404111
      Issue No: Vol. 111, No. 15 (2014)
       
  • RCAR7, abscisic acid receptor [Plant Biology]
    • Authors: Fuchs, S; Tischer, S. V, Wunschel, C, Christmann, A, Grill, E.
      Pages: 5741 - 5746
      Abstract: The plant hormone abscisic acid (ABA) acts both as a developmental signal and as an integrator of environmental cues such as drought and cold. ABA perception recruits an ABA-binding regulatory component [regulatory component of ABA receptor (RCAR)/PYR1/PYL] and an associated protein phosphatase 2C (PP2C). Phytohormone binding inactivates the phosphatase activity...
      PubDate: 2014-04-15T09:08:14-07:00
      DOI: 10.1073/pnas.1322085111|hwp:master-id:pnas;1322085111
      Issue No: Vol. 111, No. 15 (2014)
       
  • Locus expression signature analysis [Systems Biology]
    • Authors: Lee, E; de Ridder, J, Kool, J, Wessels, L. F. A, Bussemaker, H. J.
      Pages: 5747 - 5752
      Abstract: Retroviral insertional mutagenesis is a powerful tool for identifying putative cancer genes in mice. To uncover the regulatory mechanisms by which common insertion loci affect downstream processes, we supplemented genotyping data with genome-wide mRNA expression profiling data for 97 tumors induced by retroviral insertional mutagenesis. We developed locus expression signature...
      PubDate: 2014-04-15T09:08:14-07:00
      DOI: 10.1073/pnas.1309293111|hwp:master-id:pnas;1309293111
      Issue No: Vol. 111, No. 15 (2014)
       
  • Correction for Dong et al., Lipopeptide nanoparticles for potent and
           selective siRNA delivery in rodents and nonhuman primates [Correction]
    • Pages: 5753 - 5753
      Abstract: ENGINEERING Correction for “Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates,” by Yizhou Dong, Kevin T. Love, J. Robert Dorkin, Sasilada Sirirungruang, Yunlong Zhang, Delai Chen, Roman L. Bogorad, Hao Yin, Yi Chen, Arturo J. Vegas, Christopher A. Alabi, Gaurav Sahay, Karsten T. Olejnik, Weiheng...
      PubDate: 2014-04-15T09:08:14-07:00
      DOI: 10.1073/pnas.1404711111|hwp:master-id:pnas;1404711111
      Issue No: Vol. 111, No. 15 (2014)
       
  • Correction for Ehre et al., Overexpressing mouse model demonstrates the
           protective role of Muc5ac in the lungs [Correction]
    • Pages: 5753 - 5753
      Abstract: BIOCHEMISTRY Correction for “Overexpressing mouse model demonstrates the protective role of Muc5ac in the lungs,” by Camille Ehre, Erin N. Worthington, Rachael M. Liesman, Barbara R. Grubb, Diane Barbier, Wanda K. O’Neal, Jean-Michel Sallenave, Raymond J. Pickles, and Richard C. Boucher, which appeared in issue 41, October 9, 2012, of...
      PubDate: 2014-04-15T09:08:14-07:00
      DOI: 10.1073/pnas.1405175111|hwp:master-id:pnas;1405175111
      Issue No: Vol. 111, No. 15 (2014)
       
  • Correction for Tompkins et al., Testing Turing's theory of morphogenesis
           in chemical cells [Correction]
    • Pages: 5753 - 5753
      Abstract: PHYSICS Correction for “Testing Turing’s theory of morphogenesis in chemical cells,” by Nathan Tompkins, Ning Li, Camille Girabawe, Michael Heymann, G. Bard Ermentrout, Irving R. Epstein, and Seth Fraden, which appeared in issue 12, March 25, 2014, of Proc Natl Acad Sci USA (111:4397–4402; first published March 10, 2014; 10.1073/pnas.1322005111)....
      PubDate: 2014-04-15T09:08:14-07:00
      DOI: 10.1073/pnas.1405180111|hwp:master-id:pnas;1405180111
      Issue No: Vol. 111, No. 15 (2014)
       
  • Correction for Kusaba et al., Differentiated kidney epithelial cells
           repair injured proximal tubule [Correction]
    • Pages: 5754 - 5754
      Abstract: MEDICAL SCIENCES Correction for “Differentiated kidney epithelial cells repair injured proximal tubule,” by Tetsuro Kusaba, Matthew Lalli, Rafael Kramann, Akio Kobayashi, and Benjamin D. Humphreys, which appeared in issue 4, January 28, 2014, of Proc Natl Acad Sci USA (111:1527–1532; first published October 14, 2013; 10.1073/pnas.1310653110). The authors note that...
      PubDate: 2014-04-15T09:08:14-07:00
      DOI: 10.1073/pnas.1403446111|hwp:master-id:pnas;1403446111
      Issue No: Vol. 111, No. 15 (2014)
       
 
 
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