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Proceedings of the National Academy of Sciences

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ISSN (Print) 0027-8424 - ISSN (Online) 1091-6490
Published by Proceedings of the National Academy of Sciences (PNAS)

[1 journal]

JH/Met control mosquito gene expression [Developmental Biology]
- Authors: Zou, Z; Saha, T. T, Roy, S, Shin, S. W, Backman, T. W. H, Girke, T, White, K. P, Raikhel, A. S.
  Pages: E2173 - E2181
  Abstract: Juvenile hormone III (JH) plays a key role in regulating the reproduction of female mosquitoes. Microarray time-course analysis revealed dynamic changes in gene expression during posteclosion (PE) development in the fat body of female Aedes aegypti. Hierarchical clustering identified three major gene clusters: 1,843 early-PE (EPE) genes maximally expressed at...
  PubDate: 2013-06-11T09:03:29-07:00
  DOI: 10.1073/pnas.1305293110|hwp:master-id:pnas;1305293110
  Issue No: Vol. 110, No. 24 (2013)
Sequestration of a highly reactive intermediate [Evolution]
- Authors: Yadid, I; Rudolph, J, Hlouchova, K, Copley, S. D.
  Pages: E2182 - E2190
  Abstract: Microbes in contaminated environments often evolve new metabolic pathways for detoxification or degradation of pollutants. In some cases, intermediates in newly evolved pathways are more toxic than the initial compound. The initial step in the degradation of pentachlorophenol by Sphingobium chlorophenolicum generates a particularly reactive intermediate; tetrachlorobenzoquinone (TCBQ) is a...
  PubDate: 2013-06-11T09:03:29-07:00
  DOI: 10.1073/pnas.1214052110|hwp:master-id:pnas;1214052110
  Issue No: Vol. 110, No. 24 (2013)
Immortal nontransformed macrophages [Immunology]
- Authors: Fe&jnodot;er, G; Wegner, M. D, Gyory, I, Cohen, I, Engelhard, P, Voronov, E, Manke, T, Ruzsics, Z, Dolken, L, Prazeres da Costa, O, Branzk, N, Huber, M, Prasse, A, Schneider, R, Apte, R. N, Galanos, C, Freudenberg, M. A.
  Pages: E2191 - E2198
  Abstract: Macrophages are diverse cell types in the first line of antimicrobial defense. Only a limited number of primary mouse models exist to study their function. Bone marrow-derived, macrophage-CSF–induced cells with a limited life span are the most common source. We report here a simple method yielding self-renewing, nontransformed, GM-CSF/signal transducer...
  PubDate: 2013-06-11T09:03:29-07:00
  DOI: 10.1073/pnas.1302877110|hwp:master-id:pnas;1302877110
  Issue No: Vol. 110, No. 24 (2013)
Identification of dietary apigenin human targets [Applied Biological Sciences]
- Authors: Arango, D; Morohashi, K, Yilmaz, A, Kuramochi, K, Parihar, A, Brahimaj, B, Grotewold, E, Doseff, A. I.
  Pages: E2153 - E2162
  Abstract: Flavonoids constitute the largest class of dietary phytochemicals, adding essential health value to our diet, and are emerging as key nutraceuticals. Cellular targets for dietary phytochemicals remain largely unknown, posing significant challenges for the regulation of dietary supplements and the understanding of how nutraceuticals provide health value. Here, we describe...
  PubDate: 2013-06-11T09:03:29-07:00
  DOI: 10.1073/pnas.1303726110|hwp:master-id:pnas;1303726110
  Issue No: Vol. 110, No. 24 (2013)
Cell type-specific neoplasia in Drosophila [Developmental Biology]
- Authors: Khan, S. J; Bajpai, A, Alam, M. A, Gupta, R. P, Harsh, S, Pandey, R. K, Goel-Bhattacharya, S, Nigam, A, Mishra, A, Sinha, P.
  Pages: E2163 - E2172
  Abstract: Only select cell types in an organ display neoplasia when targeted oncogenically. How developmental lineage hierarchies of these cells prefigure their neoplastic propensities is not yet well-understood. Here we show that neoplastic Drosophila epithelial cells reverse their developmental commitments and switch to primitive cell states. In a context of alleviated...
  PubDate: 2013-06-11T09:03:29-07:00
  DOI: 10.1073/pnas.1212513110|hwp:master-id:pnas;1212513110
  Issue No: Vol. 110, No. 24 (2013)
Richness increases with habitat diversity [Biological Sciences]
- Authors: Hortal, J; Carrascal, L. M, Triantis, K. A, Thebault, E, Meiri, S, Sfenthourakis, S.
  Pages: E2149 - E2150
  Abstract: In the paper by Allouche et al. (1), the authors suggested that species richness decreases at high levels of habitat diversity because the area available per habitat decreases [area–heterogeneity tradeoff hypothesis (AHTO)]. They showed a hump-shaped relationship between Catalonian bird richness and altitudinal range in grid cells, the authors’ surrogate...
  Keywords: Letters
  PubDate: 2013-06-11T09:03:29-07:00
  DOI: 10.1073/pnas.1301663110|hwp:master-id:pnas;1301663110
  Issue No: Vol. 110, No. 24 (2013)
Bird distribution in Spain supports the AHTO [Biological Sciences]
- Authors: Allouche, O; Kalyuzhny, M, Moreno-Rueda, G, Pizarro, M, Kadmon, R.
  Pages: E2151 - E2152
  Abstract: Niche theory predicts that species diversity should increase with increased environmental heterogeneity. In contrast to this prediction, breeding bird diversity in Catalonia shows an overall unimodal heterogeneity–diversity relationship (HDR). We attributed this result to a fundamental geometric constraint termed the area–heterogeneity tradeoff (AHTO) (1). Hortal et al. (2) reject our...
  Keywords: Letters
  PubDate: 2013-06-11T09:03:29-07:00
  DOI: 10.1073/pnas.1305057110|hwp:master-id:pnas;1305057110
  Issue No: Vol. 110, No. 24 (2013)
Letm1-linked metabolic defects in WHS [Physiology]
- Authors: Jiang, D; Zhao, L, Clish, C. B, Clapham, D. E.
  Pages: E2249 - E2254
  Abstract: Mitochondrial metabolism, respiration, and ATP production necessitate ion transport across the inner mitochondrial membrane. Leucine zipper-EF-hand containing transmembrane protein 1 (Letm1), one of the genes deleted in Wolf–Hirschhorn syndrome, encodes a putative mitochondrial Ca2+/H+ antiporter. Cellular Letm1 knockdown reduced Ca2+mito uptake, H+mito extrusion and impaired mitochondrial ATP generation capacity. Homozygous...
  PubDate: 2013-06-11T09:03:29-07:00
  DOI: 10.1073/pnas.1308558110|hwp:master-id:pnas;1308558110
  Issue No: Vol. 110, No. 24 (2013)
ShK-186 therapy for obesity and insulin resistance [Pharmacology]
- Authors: Upadhyay, S. K; Eckel-Mahan, K. L, Mirbolooki, M. R, Tjong, I, Griffey, S. M, Schmunk, G, Koehne, A, Halbout, B, Iadonato, S, Pedersen, B, Borrelli, E, Wang, P. H, Mukherjee, J, Sassone-Corsi, P, Chandy, K. G.
  Pages: E2239 - E2248
  Abstract: Obesity is an epidemic, calling for innovative and reliable pharmacological strategies. Here, we show that ShK-186, a selective and potent blocker of the voltage-gated Kv1.3 channel, counteracts the negative effects of increased caloric intake in mice fed a diet rich in fat and fructose. ShK-186 reduced weight gain, adiposity, and...
  PubDate: 2013-06-11T09:03:29-07:00
  DOI: 10.1073/pnas.1221206110|hwp:master-id:pnas;1221206110
  Issue No: Vol. 110, No. 24 (2013)
CB1 modulation of OX neurons in obesity [Neuroscience]
- Authors: Cristino, L; Busetto, G, Imperatore, R, Ferrandino, I, Palomba, L, Silvestri, C, Petrosino, S, Orlando, P, Bentivoglio, M, Mackie, K, Di Marzo, V.
  Pages: E2229 - E2238
  Abstract: Acute or chronic alterations in energy status alter the balance between excitatory and inhibitory synaptic transmission and associated synaptic plasticity to allow for the adaptation of energy metabolism to new homeostatic requirements. The impact of such changes on endocannabinoid and cannabinoid receptor type 1 (CB1)-mediated modulation of synaptic transmission and...
  PubDate: 2013-06-11T09:03:29-07:00
  DOI: 10.1073/pnas.1219485110|hwp:master-id:pnas;1219485110
  Issue No: Vol. 110, No. 24 (2013)
Genome and transcriptome of barley powdery mildew [Microbiology]
- Authors: Hacquard, S; Kracher, B, Maekawa, T, Vernaldi, S, Schulze-Lefert, P, Ver Loren van Themaat, E.
  Pages: E2219 - E2228
  Abstract: Barley powdery mildew, Blumeria graminis f. sp. hordei (Bgh), is an obligate biotrophic ascomycete fungal pathogen that can grow and reproduce only on living cells of wild or domesticated barley (Hordeum sp.). Domestication and deployment of resistant barley cultivars by humans selected for amplification of Bgh isolates with different virulence...
  PubDate: 2013-06-11T09:03:29-07:00
  DOI: 10.1073/pnas.1306807110|hwp:master-id:pnas;1306807110
  Issue No: Vol. 110, No. 24 (2013)
PNAG as a conserved microbial vaccine target [Microbiology]
- Authors: Cywes–Bentley, C; Skurnik, D, Zaidi, T, Roux, D, DeOliveira, R. B, Garrett, W. S, Lu, X, O'Malley, J, Kinzel, K, , Rey, A, Perrin, C, Fichorova, R. N, Kayatani, A. K. K, Maira–Litran, T, Gening, M. L, Tsvetkov, Y. E, Nifantiev, N. E, Bakaletz, L. O, Pelton, S. I, Golenbock, D. T, Pier, G. B.
  Pages: E2209 - E2218
  Abstract: Microbial capsular antigens are effective vaccines but are chemically and immunologically diverse, resulting in a major barrier to their use against multiple pathogens. A β-(1→6)–linked poly-N-acetyl-d-glucosamine (PNAG) surface capsule is synthesized by four proteins encoded in genetic loci designated intercellular adhesion in Staphylococcus aureus or polyglucosamine in selected Gram-negative bacterial...
  PubDate: 2013-06-11T09:03:29-07:00
  DOI: 10.1073/pnas.1303573110|hwp:master-id:pnas;1303573110
  Issue No: Vol. 110, No. 24 (2013)
Immunotherapy with innate pro-B-cell progenitors [Immunology]
- Authors: Montandon, R; Korniotis, S, Layseca–Espinosa, E, Gras, C, Megret, J, Ezine, S, Dy, M, Zavala, F.
  Pages: E2199 - E2208
  Abstract: Diverse hematopoietic progenitors, including myeloid populations arising in inflammatory and tumoral conditions and multipotent cells, mobilized by hematopoietic growth factors or emerging during parasitic infections, display tolerogenic properties. Innate immune stimuli confer regulatory functions to various mature B-cell subsets but immature B-cell progenitors endowed with suppressive properties per se or...
  PubDate: 2013-06-11T09:03:29-07:00
  DOI: 10.1073/pnas.1222446110|hwp:master-id:pnas;1222446110
  Issue No: Vol. 110, No. 24 (2013)
Biomineralization toolkit proteome [Biological Sciences]
- Authors: Ramos-Silva, P; Marin, F, Kaandorp, J, Marie, B.
  Pages: E2144 - E2146
  Abstract: In an interesting work published recently in PNAS, Drake et al. (1) presented a proteomic study of the skeleton from the stony coral Stylophora pistillata. This study identified proteins that are associated to the mineral phase (i.e., that potentially contribute to shape the skeleton). In other words, this set of...
  Keywords: Letters
  PubDate: 2013-06-11T09:03:28-07:00
  DOI: 10.1073/pnas.1303657110|hwp:master-id:pnas;1303657110
  Issue No: Vol. 110, No. 24 (2013)
Coral skeletal proteome response [Biological Sciences]
- Authors: Drake, J. L; Mass, T, Haramaty, L, Zelzion, E, Bhattacharya, D, Falkowski, P. G.
  Pages: E2147 - E2148
  Abstract: We thank Ramos-Silva et al. (1) for their thoughtful comments on our work recently published in PNAS (2). We agree that careful cleaning of biomineral samples is indeed necessary for appropriate proteomic analysis. However, we respectfully disagree with their interpretation of our cleaning methods and our decision to include certain...
  Keywords: Letters
  PubDate: 2013-06-11T09:03:28-07:00
  DOI: 10.1073/pnas.1304591110|hwp:master-id:pnas;1304591110
  Issue No: Vol. 110, No. 24 (2013)
In This Issue [This Week in PNAS]
- Pages: 9615 - 9616
  Abstract: Measuring researchers’ scientific impact Using publication data to measure researchers’ scientific impact has become increasingly complicated partly due to the rise in interdisciplinary collaboration. Direct measures of publication quantity and citations by other researchers may not accurately reflect individual contributions on multiauthor papers. Jonathan Stallings et al. (pp. 9680–9685) developed...
  PubDate: 2013-06-11T09:03:22-07:00
  DOI: 10.1073/iti2413110|hwp:resource-id:pnas;110/24/9615
  Issue No: Vol. 110, No. 24 (2013)
Seeing sea spray by the seashore [Inner Workings]
- Authors: Powell; D.
  Pages: 9617 - 9617
  Abstract: The ocean-atmosphere wave flume (33 × 0.5 × 1 m) facility at Scripps Institution of Oceanography, University of California, San Diego. Surfers aren't the only ones chasing the perfect wave in California. After more than a year spent refurbishing an old metal tank, atmospheric chemist Kimberly Prather can recreate in...
  Keywords: Inner Workings
  PubDate: 2013-06-11T09:03:22-07:00
  DOI: 10.1073/pnas.1309455110|hwp:resource-id:pnas;110/24/9617
  Issue No: Vol. 110, No. 24 (2013)
QnAs with Roger D. Cone [QnAs]
- Authors: Griswold; A.
  Pages: 9618 - 9618
  Abstract: The factors underlying obesity are multifaceted, but recent research suggests that the brain’s melanocortin circuits, which play a key role in controlling the balance between energy consumption and use, lie at the heart of obesity. According to Roger D. Cone, elected to the National Academy of Sciences in 2010 and...
  Keywords: QnAs
  PubDate: 2013-06-11T09:03:22-07:00
  DOI: 10.1073/pnas.1308417110|hwp:master-id:pnas;1308417110
  Issue No: Vol. 110, No. 24 (2013)
Francis H. Ruddle [Retrospectives]
- Authors: Kucherlapati; R.
  Pages: 9619 - 9620
  Abstract: Frank was born August 19, 1929, in West New York, New Jersey, to immigrant parents. It was said that his Welsh-English heritage defined his personality and his unique sense of humor. He joined the Air Force in 1946 to serve our country before finishing high school. After excellent service, he...
  Keywords: Retrospectives
  PubDate: 2013-06-11T09:03:22-07:00
  DOI: 10.1073/pnas.1308094110|hwp:master-id:pnas;1308094110
  Issue No: Vol. 110, No. 24 (2013)
Making big cells [Commentary]
- Authors: Calvi; B. R.
  Pages: 9621 - 9622
  Abstract: During cell division, the genome is fully duplicated and then segregated to two daughter cells. In some tissues, however, cells repeatedly duplicate their genome and grow without dividing. This process results in large cells with many copies of their genome, a state known as polyploidy. In polyploid cells of the...
  PubDate: 2013-06-11T09:03:22-07:00
  DOI: 10.1073/pnas.1306908110|hwp:master-id:pnas;1306908110
  Issue No: Vol. 110, No. 24 (2013)
JH and mosquito fat body development [Commentary]
- Authors: Riddiford; L. M.
  Pages: 9623 - 9624
  Abstract: Mosquitoes are vectors of some of the world’s most devastating human diseases: malaria, dengue fever, and yellow fever in the tropics, and encephalitis and West Nile virus in the United States. The female mosquito usually requires a blood meal before she makes a batch of eggs, and one for each...
  PubDate: 2013-06-11T09:03:22-07:00
  DOI: 10.1073/pnas.1307487110|hwp:master-id:pnas;1307487110
  Issue No: Vol. 110, No. 24 (2013)
Endocannabinoid function in orexin neurons [Neuroscience]
- Authors: Alpar, A; Harkany, T.
  Pages: 9625 - 9626
  Abstract: Obesity is a pressing health problem affecting more than one-third of adults in the United States and Europe. Besides their increased risk to develop cardiovascular disease and type 2 diabetes, metabolic disturbances in overweight individuals affect sleeping behavior, promoting arousal and feeding (1). Task-dependent recruitment of diverse neuropeptidergic neurons in...
  PubDate: 2013-06-11T09:03:22-07:00
  DOI: 10.1073/pnas.1307389110|hwp:master-id:pnas;1307389110
  Issue No: Vol. 110, No. 24 (2013)
Ribosomal ambiguity made less ambiguous [Biochemistry]
- Authors: Moore; P. B.
  Pages: 9627 - 9628
  Abstract: In PNAS, Fagan et al. (1) report a significant step forward in the quest to understand how the fidelity with which ribosomes translate the sequences of mRNAs into protein sequences is determined. The crystal structures discussed in this paper show that the B8 bridge between the two ribosomal subunits is...
  PubDate: 2013-06-11T09:03:22-07:00
  DOI: 10.1073/pnas.1307288110|hwp:master-id:pnas;1307288110
  Issue No: Vol. 110, No. 24 (2013)
The cost of efficiency in energy metabolism [Systems Biology]
- Authors: Stettner, A. I; Segre, D.
  Pages: 9629 - 9630
  Abstract: In a universe being dragged into disorder by the second law of thermodynamics, living cells must expend energy to maintain their complex organization. In addition to providing a carbon source for biosynthesis, the classical Embden–Meyerhof–Parnas (EMP) and Entner-Doudoroff (ED) pathways help to satisfy this energetic demand by generating ATP during...
  PubDate: 2013-06-11T09:03:22-07:00
  DOI: 10.1073/pnas.1307485110|hwp:master-id:pnas;1307485110
  Issue No: Vol. 110, No. 24 (2013)
Gate-tunable polarized phase at LAO/STO interface [Applied Physical Sciences]
- Authors: Joshua, A; Ruhman, J, Pecker, S, Altman, E, Ilani, S.
  Pages: 9633 - 9638
  Abstract: Controlling the coupling between localized spins and itinerant electrons can lead to exotic magnetic states. A novel system featuring local magnetic moments and extended 2D electrons is the interface between LaAlO3 and SrTiO3. The magnetism of the interface, however, was observed to be insensitive to the presence of these electrons...
  PubDate: 2013-06-11T09:03:22-07:00
  DOI: 10.1073/pnas.1221453110|hwp:master-id:pnas;1221453110
  Issue No: Vol. 110, No. 24 (2013)
Charge-resonance stabilization in bis-Fe(IV) MauG [Biochemistry]
- Authors: Geng, J; Dornevil, K, Davidson, V. L, Liu, A.
  Pages: 9639 - 9644
  Abstract: The diheme enzyme MauG catalyzes posttranslational modifications of a methylamine dehydrogenase precursor protein to generate a tryptophan tryptophylquinone cofactor. The MauG-catalyzed reaction proceeds via a bis-Fe(IV) intermediate in which one heme is present as Fe(IV)=O and the other as Fe(IV) with axial histidine and tyrosine ligation. Herein, a unique near-infrared...
  PubDate: 2013-06-11T09:03:22-07:00
  DOI: 10.1073/pnas.1301544110|hwp:master-id:pnas;1301544110
  Issue No: Vol. 110, No. 24 (2013)
Eocene cooling and Tasmanian Gateway [Earth, Atmospheric, and Planetary Sciences]
- Authors: Bi&jnodot;l, P. K; Bendle, J. A. P, Bohaty, S. M, Pross, J, Schouten, S, Tauxe, L, Stickley, C. E, McKay, R. M, Rohl, U, Olney, M, Slui&jnodot;s, A, Escutia, C, Brinkhuis, H, Expedition 318 Scientists
  Pages: 9645 - 9650
  Abstract: The warmest global temperatures of the past 85 million years occurred during a prolonged greenhouse episode known as the Early Eocene Climatic Optimum (52–50 Ma). The Early Eocene Climatic Optimum terminated with a long-term cooling trend that culminated in continental-scale glaciation of Antarctica from 34 Ma onward. Whereas early studies...
  PubDate: 2013-06-11T09:03:22-07:00
  DOI: 10.1073/pnas.1220872110|hwp:master-id:pnas;1220872110
  Issue No: Vol. 110, No. 24 (2013)
Collapses of Northern Hemisphere monsoons [Earth, Atmospheric, and Planetary Sciences]
- Authors: Asmerom, Y; Polyak, V. J, Rasmussen, J. B. T, Burns, S. J, Lachniet, M.
  Pages: 9651 - 9656
  Abstract: Late Holocene climate in western North America was punctuated by periods of extended aridity called megadroughts. These droughts have been linked to cool eastern tropical Pacific sea surface temperatures (SSTs). Here, we show both short-term and long-term climate variability over the last 1,500 y from annual band thickness and stable...
  PubDate: 2013-06-11T09:03:22-07:00
  DOI: 10.1073/pnas.1214870110|hwp:master-id:pnas;1214870110
  Issue No: Vol. 110, No. 24 (2013)
Asynchronous marine-terrestrial climate changes [Earth, Atmospheric, and Planetary Sciences]
- Authors: Xu, D; Lu, H, Wu, N, Liu, Z, Li, T, Shen, C, Wang, L.
  Pages: 9657 - 9662
  Abstract: A high-resolution multiproxy record, including pollen, foraminifera, and alkenone paleothermometry, obtained from a single core (DG9603) from the Okinawa Trough, East China Sea (ECS), provided unambiguous evidence for asynchronous climate change between the land and ocean over the past 40 ka. On land, the deglacial stage was characterized by rapid...
  PubDate: 2013-06-11T09:03:22-07:00
  DOI: 10.1073/pnas.1300025110|hwp:master-id:pnas;1300025110
  Issue No: Vol. 110, No. 24 (2013)
Slab-derived saline fluids [Earth, Atmospheric, and Planetary Sciences]
- Authors: Kawamoto, T; Yoshikawa, M, Kumagai, Y, Mirabueno, M. H. T, Okuno, M, Kobayashi, T.
  Pages: 9663 - 9668
  Abstract: Slab-derived fluids play an important role in heat and material transfer in subduction zones. Dehydration and decarbonation reactions of minerals in the subducting slab have been investigated using phase equilibria and modeling of fluid flow. Nevertheless, direct observations of the fluid chemistry and pressure–temperature conditions of fluids are few. This...
  PubDate: 2013-06-11T09:03:22-07:00
  DOI: 10.1073/pnas.1302040110|hwp:master-id:pnas;1302040110
  Issue No: Vol. 110, No. 24 (2013)
Curves, dynamical systems, and point counting [Mathematics]
- Authors: Cornelissen; G.
  Pages: 9669 - 9673
  Abstract: Suppose X is a (smooth projective irreducible algebraic) curve over a finite field k. Counting the number of points on X over all finite field extensions of k will not determine the curve uniquely. Actually, a famous theorem of Tate implies that two such curves over k have the same...
  PubDate: 2013-06-11T09:03:22-07:00
  DOI: 10.1073/pnas.1217710110|hwp:master-id:pnas;1217710110
  Issue No: Vol. 110, No. 24 (2013)
Ionic liquids behave as dilute electrolytes [Physics]
- Authors: Gebbie, M. A; Valtiner, M, Banquy, X, Fox, E. T, Henderson, W. A, Israelachvili, J. N.
  Pages: 9674 - 9679
  Abstract: We combine direct surface force measurements with thermodynamic arguments to demonstrate that pure ionic liquids are expected to behave as dilute weak electrolyte solutions, with typical effective dissociated ion concentrations of less than 0.1% at room temperature. We performed equilibrium force–distance measurements across the common ionic liquid 1-butyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide ([C4mim][NTf2])...
  PubDate: 2013-06-11T09:03:22-07:00
  DOI: 10.1073/pnas.1307871110|hwp:master-id:pnas;1307871110
  Issue No: Vol. 110, No. 24 (2013)
Scientific impact using a collaboration index [Statistics]
- Authors: Stallings, J; Vance, E, Yang, J, Vannier, M. W, Liang, J, Pang, L, Dai, L, Ye, I, Wang, G.
  Pages: 9680 - 9685
  Abstract: Researchers collaborate on scientific projects that are often measured by both the quantity and the quality of the resultant peer-reviewed publications. However, not all collaborators contribute to these publications equally, making metrics such as the total number of publications and the H-index insufficient measurements of individual scientific impact. To remedy...
  PubDate: 2013-06-11T09:03:22-07:00
  DOI: 10.1073/pnas.1220184110|hwp:master-id:pnas;1220184110
  Issue No: Vol. 110, No. 24 (2013)
Expert assessments of small modular reactor costs [Sustainability Science]
- Authors: Abdulla, A; Azevedo, I. L, Morgan, M. G.
  Pages: 9686 - 9691
  Abstract: Analysts and decision makers frequently want estimates of the cost of technologies that have yet to be developed or deployed. Small modular reactors (SMRs), which could become part of a portfolio of carbon-free energy sources, are one such technology. Existing estimates of likely SMR costs rely on problematic top-down approaches...
  Keywords: Sustainability Science
  PubDate: 2013-06-11T09:03:22-07:00
  DOI: 10.1073/pnas.1300195110|hwp:master-id:pnas;1300195110
  Issue No: Vol. 110, No. 24 (2013)
Molecular genetics and subjective well-being [Genetics]
- Authors: Rietveld, C. A; Cesarini, D, Benjamin, D. J, Koellinger, P. D, De Neve, J.-E, Tiemeier, H, Johannesson, M, Magnusson, P. K. E, Pedersen, N. L, Krueger, R. F, Bartels, M.
  Pages: 9692 - 9697
  Abstract: Subjective well-being (SWB) is a major topic of research across the social sciences. Twin and family studies have found that genetic factors may account for as much as 30–40% of the variance in SWB. Here, we study genetic contributions to SWB in a pooled sample of ≈11,500 unrelated, comprehensively-genotyped Swedish...
  PubDate: 2013-06-11T09:03:22-07:00
  DOI: 10.1073/pnas.1222171110|hwp:master-id:pnas;1222171110
  Issue No: Vol. 110, No. 24 (2013)
Parametric estimation in language competition [Evolution]
- Authors: Zhang, M; Gong, T.
  Pages: 9698 - 9703
  Abstract: It is generally difficult to define reasonable parameters and interpret their values in mathematical models of social phenomena. Rather than directly fitting abstract parameters against empirical data, we should define some concrete parameters to denote the sociocultural factors relevant for particular phenomena, and compute the values of these parameters based...
  PubDate: 2013-06-11T09:03:23-07:00
  DOI: 10.1073/pnas.1303108110|hwp:master-id:pnas;1303108110
  Issue No: Vol. 110, No. 24 (2013)
Mass spectrometry of a multidrug resistance pump [Chemistry]
- Authors: Marcoux, J; Wang, S. C, Politis, A, Reading, E, Ma, J, Biggin, P. C, Zhou, M, Tao, H, Zhang, Q, Chang, G, Morgner, N, Robinson, C. V.
  Pages: 9704 - 9709
  Abstract: Multidrug resistance is a serious barrier to successful treatment of many human diseases, including cancer, wherein chemotherapeutics are exported from target cells by membrane-embedded pumps. The most prevalent of these pumps, the ATP-Binding Cassette transporter P-glycoprotein (P-gp), consists of two homologous halves each comprising one nucleotide-binding domain and six transmembrane...
  PubDate: 2013-06-11T09:03:23-07:00
  DOI: 10.1073/pnas.1303888110|hwp:master-id:pnas;1303888110
  Issue No: Vol. 110, No. 24 (2013)
Structures of ABCB10, a human ABC transporter [Biochemistry]
- Authors: Shintre, C. A; Pike, A. C. W, Li, Q, Kim, J.-I, Barr, A. J, Goubin, S, Shrestha, L, Yang, J, Berridge, G, Ross, J, Stansfeld, P. J, Sansom, M. S. P, Edwards, A. M, Bountra, C, Marsden, B. D, von Delft, F, Bullock, A. N, Gileadi, O, Burgess-Brown, N. A, Carpenter, E. P.
  Pages: 9710 - 9715
  Abstract: ABCB10 is one of the three ATP-binding cassette (ABC) transporters found in the inner membrane of mitochondria. In mammals ABCB10 is essential for erythropoiesis, and for protection of mitochondria against oxidative stress. ABCB10 is therefore a potential therapeutic target for diseases in which increased mitochondrial reactive oxygen species production and...
  PubDate: 2013-06-11T09:03:23-07:00
  DOI: 10.1073/pnas.1217042110|hwp:master-id:pnas;1217042110
  Issue No: Vol. 110, No. 24 (2013)
Structural basis for rRNA ram mutations [Biochemistry]
- Authors: Fagan, C. E; Dunkle, J. A, Maehigashi, T, Dang, M. N, Devaraj, A, Miles, S. J, Qin, D, Fredrick, K, Dunham, C. M.
  Pages: 9716 - 9721
  Abstract: After four decades of research aimed at understanding tRNA selection on the ribosome, the mechanism by which ribosomal ambiguity (ram) mutations promote miscoding remains unclear. Here, we present two X-ray crystal structures of the Thermus thermophilus 70S ribosome containing 16S rRNA ram mutations, G347U and G299A. Each of these mutations...
  PubDate: 2013-06-11T09:03:23-07:00
  DOI: 10.1073/pnas.1301585110|hwp:master-id:pnas;1301585110
  Issue No: Vol. 110, No. 24 (2013)
Pirin is a nonheme Fe-based redox sensor [Biochemistry]
- Authors: Liu, F; Rehmani, I, Esaki, S, Fu, R, Chen, L, de Serrano, V, Liu, A.
  Pages: 9722 - 9727
  Abstract: Pirin is a nuclear nonheme Fe protein of unknown function present in all human tissues. Here we describe that pirin may act as a redox sensor for the nuclear factor κB (NF-κB) transcription factor, a critical mediator of intracellular signaling that has been linked to cellular responses to proinflammatory signals...
  PubDate: 2013-06-11T09:03:23-07:00
  DOI: 10.1073/pnas.1221743110|hwp:master-id:pnas;1221743110
  Issue No: Vol. 110, No. 24 (2013)
Inhibitors of mitochondrial BCKD kinase [Biochemistry]
- Authors: Tso, S.-C; Qi, X, Gui, W.-J, Chuang, J. L, Morlock, L. K, Wallace, A. L, Ahmed, K, Laxman, S, Campeau, P. M, Lee, B. H, Hutson, S. M, Tu, B. P, Williams, N. S, Tambar, U. K, Wynn, R. M, Chuang, D. T.
  Pages: 9728 - 9733
  Abstract: The branched-chain amino acids (BCAAs) leucine, isoleucine, and valine are elevated in maple syrup urine disease, heart failure, obesity, and type 2 diabetes. BCAA homeostasis is controlled by the mitochondrial branched-chain α-ketoacid dehydrogenase complex (BCKDC), which is negatively regulated by the specific BCKD kinase (BDK). Here, we used structure-based design...
  PubDate: 2013-06-11T09:03:23-07:00
  DOI: 10.1073/pnas.1303220110|hwp:master-id:pnas;1303220110
  Issue No: Vol. 110, No. 24 (2013)
MPIase is essential for SecG inversion [Biochemistry]
- Authors: Moser, M; Nagamori, S, Huber, M, Tokuda, H, Nishiyama, K.-i.
  Pages: 9734 - 9739
  Abstract: Presecretory proteins are translocated across biological membranes through protein-conducting channels such as Sec61 (eukaryotes) and SecYEG (bacteria). SecA, a translocation ATPase, pushes preproteins out with dynamic structural changes through SecYEG. SecG, a subunit of the SecYEG channel possessing two transmembrane stretches (TMs), undergoes topology inversion coupled with SecA-dependent translocation. Recently,...
  PubDate: 2013-06-11T09:03:23-07:00
  DOI: 10.1073/pnas.1303160110|hwp:master-id:pnas;1303160110
  Issue No: Vol. 110, No. 24 (2013)
RNA polymerase promoter approach without sliding [Biochemistry]
- Authors: Friedman, L. J; Mumm, J. P, Gelles, J.
  Pages: 9740 - 9745
  Abstract: Sequence-specific DNA binding proteins must quickly bind target sequences, despite the enormously larger amount of nontarget DNA present in cells. RNA polymerases (or associated general transcription factors) are hypothesized to reach promoter sequences by facilitated diffusion (FD). In FD, a protein first binds to nontarget DNA and then reaches the...
  PubDate: 2013-06-11T09:03:23-07:00
  DOI: 10.1073/pnas.1300221110|hwp:master-id:pnas;1300221110
  Issue No: Vol. 110, No. 24 (2013)
Climbing, falling, and jamming in tunnels [Applied Physical Sciences]
- Authors: Gravish, N; Monaenkova, D, Goodisman, M. A. D, Goldman, D. I.
  Pages: 9746 - 9751
  Abstract: Locomotion emerges from effective interactions of an individual with its environment. Principles of biological terrestrial locomotion have been discovered on unconfined vertical and horizontal substrates. However, a diversity of organisms construct, inhabit, and move within confined spaces. Such animals are faced with locomotor challenges including limited limb range of motion,...
  PubDate: 2013-06-11T09:03:24-07:00
  DOI: 10.1073/pnas.1302428110|hwp:master-id:pnas;1302428110
  Issue No: Vol. 110, No. 24 (2013)
Tension modulates actin polymerization by formin [Biophysics and Computational Biology]
- Authors: Courtemanche, N; Lee, J. Y, Pollard, T. D, Greene, E. C.
  Pages: 9752 - 9757
  Abstract: Formins promote processive elongation of actin filaments for cytokinetic contractile rings and other cellular structures. In vivo, these structures are exposed to tension, but the effect of tension on these processes was unknown. Here we used single-molecule imaging to investigate the effects of tension on actin polymerization mediated by yeast...
  PubDate: 2013-06-11T09:03:24-07:00
  DOI: 10.1073/pnas.1308257110|hwp:master-id:pnas;1308257110
  Issue No: Vol. 110, No. 24 (2013)
Secondary nucleation in A{beta}42 aggregation [Biophysics and Computational Biology]
- Authors: Cohen, S. I. A; Linse, S, Luheshi, L. M, Hellstrand, E, White, D. A, Rajah, L, Otzen, D. E, Vendruscolo, M, Dobson, C. M, Knowles, T. P. J.
  Pages: 9758 - 9763
  Abstract: The generation of toxic oligomers during the aggregation of the amyloid-β (Aβ) peptide Aβ42 into amyloid fibrils and plaques has emerged as a central feature of the onset and progression of Alzheimer’s disease, but the molecular pathways that control pathological aggregation have proved challenging to identify. Here, we use a...
  PubDate: 2013-06-11T09:03:24-07:00
  DOI: 10.1073/pnas.1218402110|hwp:master-id:pnas;1218402110
  Issue No: Vol. 110, No. 24 (2013)
Polaro-crypsis in the open ocean [Biophysics and Computational Biology]
- Authors: Brady, P. C; Travis, K. A, Maginnis, T, Cummings, M. E.
  Pages: 9764 - 9769
  Abstract: With no object to hide behind in 3D space, the open ocean represents a challenging environment for camouflage. Conventional strategies for reflective crypsis (e.g., standard mirror) are effective against axially symmetric radiance fields associated with high solar altitudes, yet ineffective against asymmetric polarized radiance fields associated with low solar inclinations....
  PubDate: 2013-06-11T09:03:24-07:00
  DOI: 10.1073/pnas.1222125110|hwp:master-id:pnas;1222125110
  Issue No: Vol. 110, No. 24 (2013)
Failing myocardium on a chip [Biophysics and Computational Biology]
- Authors: McCain, M. L; Sheehy, S. P, Grosberg, A, Goss, J. A, Parker, K. K.
  Pages: 9770 - 9775
  Abstract: The lack of a robust pipeline of medical therapeutic agents for the treatment of heart disease may be partially attributed to the lack of in vitro models that recapitulate the essential structure–function relationships of healthy and diseased myocardium. We designed and built a system to mimic mechanical overload in vitro...
  PubDate: 2013-06-11T09:03:24-07:00
  DOI: 10.1073/pnas.1304913110|hwp:master-id:pnas;1304913110
  Issue No: Vol. 110, No. 24 (2013)
Proteolytic release of EGF ligands [Cell Biology]
- Authors: Dang, M; Armbruster, N, Miller, M. A, Cermeno, E, Hartmann, M, Bell, G. W, Root, D. E, Lauffenburger, D. A, Lodish, H. F, Herrlich, A.
  Pages: 9776 - 9781
  Abstract: Ectodomain cleavage of cell-surface proteins by A disintegrin and metalloproteinases (ADAMs) is highly regulated, and its dysregulation has been linked to many diseases. ADAM10 and ADAM17 cleave most disease-relevant substrates. Broad-spectrum metalloprotease inhibitors have failed clinically, and targeting the cleavage of a specific substrate has remained impossible. It is therefore...
  PubDate: 2013-06-11T09:03:24-07:00
  DOI: 10.1073/pnas.1307478110|hwp:master-id:pnas;1307478110
  Issue No: Vol. 110, No. 24 (2013)
CIT-K controls midbody formation in cytokinesis [Cell Biology]
- Authors: Bassi, Z. I; Audusseau, M, Riparbelli, M. G, Callaini, G, D'Avino, P. P.
  Pages: 9782 - 9787
  Abstract: Cytokinesis partitions cytoplasmic and genomic materials at the end of cell division. Failure in this process causes polyploidy, which in turn can generate chromosomal instability, a hallmark of many cancers. Successful cytokinesis requires cooperative interaction between contractile ring and central spindle components, but how this cooperation is established is poorly...
  PubDate: 2013-06-11T09:03:24-07:00
  DOI: 10.1073/pnas.1301328110|hwp:master-id:pnas;1301328110
  Issue No: Vol. 110, No. 24 (2013)
How vinculin regulates force transmission [Cell Biology]
- Authors: Dumbauld, D. W; Lee, T. T, Singh, A, Scrimgeour, J, Gersbach, C. A, Zamir, E. A, Fu, J, Chen, C. S, Curtis, J. E, Craig, S. W, Garcia, A. J.
  Pages: 9788 - 9793
  Abstract: Focal adhesions mediate force transfer between ECM-integrin complexes and the cytoskeleton. Although vinculin has been implicated in force transmission, few direct measurements have been made, and there is little mechanistic insight. Using vinculin-null cells expressing vinculin mutants, we demonstrate that vinculin is not required for transmission of adhesive and traction...
  PubDate: 2013-06-11T09:03:24-07:00
  DOI: 10.1073/pnas.1216209110|hwp:master-id:pnas;1216209110
  Issue No: Vol. 110, No. 24 (2013)
Mechanism of brefeldin A-mediated ADP-ribosylation [Cell Biology]
- Authors: Colanzi, A; Grimaldi, G, Catara, G, Valente, C, Cericola, C, Liberali, P, Ronci, M, Lalioti, V. S, Bruno, A, Beccari, A. R, Urbani, A, De Flora, A, Nardini, M, Bolognesi, M, Luini, A, Corda, D.
  Pages: 9794 - 9799
  Abstract: ADP-ribosylation is a posttranslational modification that modulates the functions of many target proteins. We previously showed that the fungal toxin brefeldin A (BFA) induces the ADP-ribosylation of C-terminal–binding protein-1 short-form/BFA–ADP-ribosylation substrate (CtBP1-S/BARS), a bifunctional protein with roles in the nucleus as a transcription factor and in the cytosol as a...
  PubDate: 2013-06-11T09:03:24-07:00
  DOI: 10.1073/pnas.1222413110|hwp:master-id:pnas;1222413110
  Issue No: Vol. 110, No. 24 (2013)
Ypt1 recruits Atg1 to the PAS [Cell Biology]
- Authors: Wang, J; Menon, S, Yamasaki, A, Chou, H.-T, Walz, T, Jiang, Y, Ferro-Novick, S.
  Pages: 9800 - 9805
  Abstract: When macroautophagy, a catabolic process that rids the cells of unwanted proteins, is initiated, 30–60 nm Atg9 vesicles move from the Golgi to the preautophagosomal structure (PAS) to initiate autophagosome formation. The Rab GTPase Ypt1 and its mammalian homolog Rab1 regulate macroautophagy and two other trafficking events: endoplasmic reticulum-Golgi and...
  PubDate: 2013-06-11T09:03:24-07:00
  DOI: 10.1073/pnas.1302337110|hwp:master-id:pnas;1302337110
  Issue No: Vol. 110, No. 24 (2013)
HDACs regulate cardiac hypertrophy via DUSP5 [Cell Biology]
- Authors: Ferguson, B. S; Harrison, B. C, Jeong, M. Y, Reid, B. G, Wempe, M. F, Wagner, F. F, Holson, E. B, McKinsey, T. A.
  Pages: 9806 - 9811
  Abstract: Cardiac hypertrophy is a strong predictor of morbidity and mortality in patients with heart failure. Small molecule histone deacetylase (HDAC) inhibitors have been shown to suppress cardiac hypertrophy through mechanisms that remain poorly understood. We report that class I HDACs function as signal-dependent repressors of cardiac hypertrophy via inhibition of...
  PubDate: 2013-06-11T09:03:24-07:00
  DOI: 10.1073/pnas.1301509110|hwp:master-id:pnas;1301509110
  Issue No: Vol. 110, No. 24 (2013)
Poly(I:C) induces RAR{beta} reexpression [Cell Biology]
- Authors: Galli, R; Paone, A, Fabbri, M, Zanesi, N, Calore, F, Cascione, L, Acunzo, M, Stoppacciaro, A, Tubaro, A, Lovat, F, Gasparini, P, Fadda, P, Alder, H, Volinia, S, Filippini, A, Ziparo, E, Riccioli, A, Croce, C. M.
  Pages: 9812 - 9817
  Abstract: Toll-like receptor 3 (TLR3) is a key effector of the innate immune system against viruses. Activation of TLR3 exerts an antitumoral effect through a mechanism of action still poorly understood. Here we show that TLR3 activation by polyinosinic:polycytidylic acid induces up-regulation of microRNA-29b, -29c, -148b, and -152 in tumor-derived cell...
  PubDate: 2013-06-11T09:03:24-07:00
  DOI: 10.1073/pnas.1304610110|hwp:master-id:pnas;1304610110
  Issue No: Vol. 110, No. 24 (2013)
Regulation of translation by eIF3h [Developmental Biology]
- Authors: Choudhuri, A; Maitra, U, Evans, T.
  Pages: 9818 - 9823
  Abstract: Eukaryotic translation initiation factor 3 (eIF3) plays a central role in translation initiation and consists of five core (conserved) subunits present in both budding yeast and higher eukaryotes. Higher eukaryotic eIF3 contains additional (noncore or nonconserved) subunits of poorly defined function, including sub-unit h (eIF3h), which in zebrafish is encoded...
  PubDate: 2013-06-11T09:03:24-07:00
  DOI: 10.1073/pnas.1302934110|hwp:master-id:pnas;1302934110
  Issue No: Vol. 110, No. 24 (2013)
Global distributions of marine Cyanobacteria [Ecology]
- Authors: Flombaum, P; Gallegos, J. L, Gordillo, R. A, Rincon, J, Zabala, L. L, Jiao, N, Karl, D. M, Li, W. K. W, Lomas, M. W, Veneziano, D, Vera, C. S, Vrugt, J. A, Martiny, A. C.
  Pages: 9824 - 9829
  Abstract: The Cyanobacteria Prochlorococcus and Synechococcus account for a substantial fraction of marine primary production. Here, we present quantitative niche models for these lineages that assess present and future global abundances and distributions. These niche models are the result of neural network, nonparametric, and parametric analyses, and they rely on>35,000...
  PubDate: 2013-06-11T09:03:24-07:00
  DOI: 10.1073/pnas.1307701110|hwp:master-id:pnas;1307701110
  Issue No: Vol. 110, No. 24 (2013)
Microbialite foraminifera [Ecology]
- Authors: Bernhard, J. M; Edgcomb, V. P, Visscher, P. T, McIntyre-Wressnig, A, Summons, R. E, Bouxsein, M. L, Louis, L, Jeglinski, M.
  Pages: 9830 - 9834
  Abstract: Microbialites, which are organosedimentary structures formed by microbial communities through binding and trapping and/or in situ precipitation, have a wide array of distinctive morphologies and long geologic record. The origin of morphological variability is hotly debated; elucidating the cause or causes of microfabric differences could provide insights into ecosystem functioning...
  PubDate: 2013-06-11T09:03:24-07:00
  DOI: 10.1073/pnas.1221721110|hwp:master-id:pnas;1221721110
  Issue No: Vol. 110, No. 24 (2013)
Soil legacy effects on a plant community [Ecology]
- Authors: Meisner, A; De Deyn, G. B, de Boer, W, van der Putten, W. H.
  Pages: 9835 - 9838
  Abstract: Climate change is expected to increase future abiotic stresses on ecosystems through extreme weather events leading to more extreme drought and rainfall incidences [Jentsch A, et al. (2007) Front Ecol Environ 5(7):365–374]. These fluctuations in precipitation may affect soil biota, soil processes [Evans ST, Wallenstein MD (2012) Biogeochemistry 109:101–116], and...
  PubDate: 2013-06-11T09:03:24-07:00
  DOI: 10.1073/pnas.1300922110|hwp:master-id:pnas;1300922110
  Issue No: Vol. 110, No. 24 (2013)
Regeneration of exhumed Little Ice Age bryophytes [Environmental Sciences]
- Authors: La Farge, C; Williams, K. H, England, J. H.
  Pages: 9839 - 9844
  Abstract: Across the Canadian Arctic Archipelago, widespread ice retreat during the 20th century has sharply accelerated since 2004. In Sverdrup Pass, central Ellesmere Island, rapid glacier retreat is exposing intact plant communities whose radiocarbon dates demonstrate entombment during the Little Ice Age (1550–1850 AD). The exhumed bryophyte assemblages have exceptional structural...
  PubDate: 2013-06-11T09:03:24-07:00
  DOI: 10.1073/pnas.1304199110|hwp:master-id:pnas;1304199110
  Issue No: Vol. 110, No. 24 (2013)
microRNA in ovarian cancer chemoresistance [Genetics]
- Authors: Vecchione, A; Belletti, B, Lovat, F, Volinia, S, Chiappetta, G, Giglio, S, Sonego, M, Cirombella, R, Onesti, E. C, Pellegrini, P, Califano, D, Pignata, S, Losito, S, Canzonieri, V, Sorio, R, Alder, H, Wernicke, D, Stoppacciaro, A, Baldassarre, G, Croce, C. M.
  Pages: 9845 - 9850
  Abstract: Epithelial ovarian cancer is the most lethal gynecologic malignancy; it is highly aggressive and causes almost 125,000 deaths yearly. Despite advances in detection and cytotoxic therapies, a low percentage of patients with advanced stage disease survive 5 y after the initial diagnosis. The high mortality of this disease is mainly...
  PubDate: 2013-06-11T09:03:24-07:00
  DOI: 10.1073/pnas.1305472110|hwp:master-id:pnas;1305472110
  Issue No: Vol. 110, No. 24 (2013)
Clinical Genomic Database [Genetics]
- Authors: Solomon, B. D; Nguyen, A.-D, Bear, K. A, Wolfsberg, T. G.
  Pages: 9851 - 9855
  Abstract: Technological advances have greatly increased the availability of human genomic sequencing. However, the capacity to analyze genomic data in a clinically meaningful way lags behind the ability to generate such data. To help address this obstacle, we reviewed all conditions with genetic causes and constructed the Clinical Genomic Database (CGD)...
  PubDate: 2013-06-11T09:03:25-07:00
  DOI: 10.1073/pnas.1302575110|hwp:master-id:pnas;1302575110
  Issue No: Vol. 110, No. 24 (2013)
ZNF408 is mutated in FEVR [Genetics]
- Authors: Collin, R. W. J; Nikopoulos, K, Dona, M, Gilissen, C, Hoischen, A, Boonstra, F. N, Poulter, J. A, Kondo, H, Berger, W, Toomes, C, Tahira, T, Mohn, L. R, Blokland, E. A, Hetterschijt, L, Ali, M, Groothuismink, J. M, Duijkers, L, Inglehearn, C. F, Sollfrank, L, Strom, T. M, Uchio, E, van Nouhuys, C. E, Kremer, H, Veltman, J. A, van Wijk, E, Cremers, F. P. M.
  Pages: 9856 - 9861
  Abstract: Familial exudative vitreoretinopathy (FEVR) is a genetically heterogeneous disorder characterized by abnormal vascularization of the peripheral retina, which can result in retinal detachment and severe visual impairment. In a large Dutch FEVR family, we performed linkage analysis, exome sequencing, and segregation analysis of DNA variants. We identified putative disease-causing DNA...
  PubDate: 2013-06-11T09:03:25-07:00
  DOI: 10.1073/pnas.1220864110|hwp:master-id:pnas;1220864110
  Issue No: Vol. 110, No. 24 (2013)
Inflammasome-induced dysbiosis & colorectal cancer [Immunology]
- Authors: Hu, B; Elinav, E, Huber, S, Strowig, T, Hao, L, Hafemann, A, Jin, C, Eisenbarth, S. C, Flavell, R. A.
  Pages: 9862 - 9867
  Abstract: The microbiota is pivotal in the pathogenesis of inflammatory bowel disease (IBD)-associated inflammation-induced colorectal cancer (CRC), yet mechanisms for these effects remain poorly characterized. Here, we demonstrate that aberrant inflammasome-induced microbiota plays a critical role in CRC development, where mice deficient in the NOD-like receptor family pyrin domain containing 6...
  PubDate: 2013-06-11T09:03:26-07:00
  DOI: 10.1073/pnas.1307575110|hwp:master-id:pnas;1307575110
  Issue No: Vol. 110, No. 24 (2013)
Antibody effector function regulation [Immunology]
- Authors: Sondermann, P; Pincetic, A, Maamary, J, Lammens, K, Ravetch, J. V.
  Pages: 9868 - 9872
  Abstract: Immunoglobulins recognize and clear microbial pathogens and toxins through the coupling of variable region specificity to Fc-triggered cellular activation. These proinflammatory activities are regulated, thus avoiding the pathogenic sequelae of uncontrolled inflammation by modulating the composition of the Fc-linked glycan. Upon sialylation, the affinities for Fcγ receptors are reduced, whereas...
  PubDate: 2013-06-11T09:03:26-07:00
  DOI: 10.1073/pnas.1307864110|hwp:master-id:pnas;1307864110
  Issue No: Vol. 110, No. 24 (2013)
Phosphorylation by AMPK regulates RAG1 activity [Immunology]
- Authors: Um, J.-H; Brown, A. L, Singh, S. K, Chen, Y, Gucek, M, Lee, B.-S, Luckey, M. A, Kim, M. K, Park, J.-H, Sleckman, B. P, Gellert, M, Chung, J. H.
  Pages: 9873 - 9878
  Abstract: The ability to sense metabolic stress is critical for successful cellular adaptation. In eukaryotes, the AMP-activated protein kinase (AMPK), a highly conserved serine/threonine kinase, functions as a critical metabolic sensor. AMPK is activated by the rising ADP/ATP and AMP/ATP ratios during conditions of energy depletion and also by increasing intracellular...
  PubDate: 2013-06-11T09:03:27-07:00
  DOI: 10.1073/pnas.1307928110|hwp:master-id:pnas;1307928110
  Issue No: Vol. 110, No. 24 (2013)
Unique B7 family member [Immunology]
- Authors: Zhao, R; Chinai, J. M, Buhl, S, Scandiuzzi, L, Ray, A, Jeon, H, Ohaegbulam, K. C, Ghosh, K, Zhao, A, Scharff, M. D, Zang, X.
  Pages: 9879 - 9884
  Abstract: T-cell costimulation and coinhibition generated by engagement of the B7 family and their receptor CD28 family are of central importance in regulating the T-cell response, making these pathways very attractive therapeutic targets. Here we describe HERV–H LTR-associating protein 2 (HHLA2) as a member of the B7 family that shares 10–18%...
  PubDate: 2013-06-11T09:03:27-07:00
  DOI: 10.1073/pnas.1303524110|hwp:master-id:pnas;1303524110
  Issue No: Vol. 110, No. 24 (2013)
Aire+ mTECs originate from {beta}5t+ cells [Immunology]
- Authors: Ohigashi, I; Zuklys, S, Sakata, M, Mayer, C. E, Zhanybekova, S, Murata, S, Tanaka, K, Hollander, G. A, Takahama, Y.
  Pages: 9885 - 9890
  Abstract: The thymus provides multiple microenvironments that are essential for the development and repertoire selection of T lymphocytes. The thymic cortex induces the generation and positive selection of T lymphocytes, whereas the thymic medulla establishes self-tolerance among the positively selected T lymphocytes. Cortical thymic epithelial cells (cTECs) and medullary TECs (mTECs)...
  PubDate: 2013-06-11T09:03:27-07:00
  DOI: 10.1073/pnas.1301799110|hwp:master-id:pnas;1301799110
  Issue No: Vol. 110, No. 24 (2013)
TSH, TNF, and bone [Medical Sciences]
- Authors: Sun, L; Zhu, L.-L, Lu, P, Yuen, T, Li, J, Ma, R, Baliram, R, Moonga, S. S, Liu, P, Zallone, A, New, M. I, Davies, T. F, Zaidi, M.
  Pages: 9891 - 9896
  Abstract: Clinical data showing correlations between low thyroid-stimulating hormone (TSH) levels and high bone turnover markers, low bone mineral density, and an increased risk of osteoporosis-related fractures are buttressed by mouse genetic and pharmacological studies identifying a direct action of TSH on the skeleton. Here we show that the skeletal actions...
  PubDate: 2013-06-11T09:03:27-07:00
  DOI: 10.1073/pnas.1308336110|hwp:master-id:pnas;1308336110
  Issue No: Vol. 110, No. 24 (2013)
Circadian clock and Salmonella [Medical Sciences]
- Authors: Bellet, M. M; Deriu, E, Liu, J. Z, Grimaldi, B, Blaschitz, C, Zeller, M, Edwards, R. A, Sahar, S, Dandekar, S, Baldi, P, George, M. D, Raffatellu, M, Sassone-Corsi, P.
  Pages: 9897 - 9902
  Abstract: Organisms adapt to day–night cycles through highly specialized circadian machinery, whose molecular components anticipate and drive changes in organism behavior and metabolism. Although many effectors of the immune system are known to follow daily oscillations, the role of the circadian clock in the immune response to acute infections is not...
  PubDate: 2013-06-11T09:03:27-07:00
  DOI: 10.1073/pnas.1120636110|hwp:master-id:pnas;1120636110
  Issue No: Vol. 110, No. 24 (2013)
CNS development requires ZIP12 [Medical Sciences]
- Authors: Chowanadisai, W; Graham, D. M, Keen, C. L, Rucker, R. B, Messerli, M. A.
  Pages: 9903 - 9908
  Abstract: Zn2+ is required for many aspects of neuronal structure and function. However, the regulation of Zn2+ in the nervous system remains poorly understood. Systematic analysis of tissue-profiling microarray data showed that the zinc transporter ZIP12 (slc39a12) is highly expressed in the human brain. In the work reported here, we confirmed...
  PubDate: 2013-06-11T09:03:27-07:00
  DOI: 10.1073/pnas.1222142110|hwp:master-id:pnas;1222142110
  Issue No: Vol. 110, No. 24 (2013)
PKG oxidation mediates injury during sepsis [Medical Sciences]
- Authors: Rudyk, O; Phinikaridou, A, Prysyazhna, O, Burgoyne, J. R, Botnar, R. M, Eaton, P.
  Pages: 9909 - 9913
  Abstract: Sepsis is a common life-threatening clinical syndrome involving complications as a result of severe infection. A cardinal feature of sepsis is inflammation that results in oxidative stress. Sepsis in wild-type mice induced oxidative activation of cGMP-dependent protein kinase 1 alpha (PKG Iα), which increased blood vessel dilation and permeability, and...
  PubDate: 2013-06-11T09:03:27-07:00
  DOI: 10.1073/pnas.1301026110|hwp:master-id:pnas;1301026110
  Issue No: Vol. 110, No. 24 (2013)
Eosinophils stimulate liver regeneration via IL-4 [Medical Sciences]
- Authors: Goh, Y. P. S; Henderson, N. C, Heredia, J. E, Red Eagle, A, Odegaard, J. I, Lehwald, N, Nguyen, K. D, Sheppard, D, Mukundan, L, Locksley, R. M, Chawla, A.
  Pages: 9914 - 9919
  Abstract: The liver is a central organ for the synthesis and storage of nutrients, production of serum proteins and hormones, and breakdown of toxins and metabolites. Because the liver is susceptible to toxin- or pathogen-mediated injury, it maintains a remarkable capacity to regenerate by compensatory growth. Specifically, in response to injury,...
  PubDate: 2013-06-11T09:03:27-07:00
  DOI: 10.1073/pnas.1304046110|hwp:master-id:pnas;1304046110
  Issue No: Vol. 110, No. 24 (2013)
HMGA2/TET1/HOXA9 in breast cancer [Medical Sciences]
- Authors: Sun, M; Song, C.-X, Huang, H, Frankenberger, C. A, Sankarasharma, D, Gomes, S, Chen, P, Chen, J, Chada, K. K, He, C, Rosner, M. R.
  Pages: 9920 - 9925
  Abstract: The ten–eleven translocation (TET) family of methylcytosine dioxygenases initiates demethylation of DNA and is associated with tumorigenesis in many cancers; however, the mechanism is mostly unknown. Here we identify upstream activators and downstream effectors of TET1 in breast cancer using human breast cancer cells and a genetically engineered mouse model....
  PubDate: 2013-06-11T09:03:27-07:00
  DOI: 10.1073/pnas.1305172110|hwp:master-id:pnas;1305172110
  Issue No: Vol. 110, No. 24 (2013)
Autoinducer-mediated bacterial resuscitation [Microbiology]
- Authors: Bari, S. M. N; Roky, M. K, Mohiuddin, M, Kamruzzaman, M, Mekalanos, J. J, Faruque, S. M.
  Pages: 9926 - 9931
  Abstract: Cholera epidemics have long been known to spread through water contaminated with human fecal material containing the toxigenic bacterium Vibrio cholerae. However, detection of V. cholerae in water is complicated by the existence of a dormant state in which the organism remains viable, but resists cultivation on routine bacteriological media....
  PubDate: 2013-06-11T09:03:27-07:00
  DOI: 10.1073/pnas.1307697110|hwp:master-id:pnas;1307697110
  Issue No: Vol. 110, No. 24 (2013)
CCT mediates cytosolic delivery of anthrax toxin [Microbiology]
- Authors: Slater, L. H; Hett, E. C, Clatworthy, A. E, Mark, K. G, Hung, D. T.
  Pages: 9932 - 9937
  Abstract: Bacterial toxins have evolved successful strategies for coopting host proteins to access the cytosol of host cells. Anthrax lethal factor (LF) enters the cytosol through pores in the endosomal membrane formed by anthrax protective antigen. Although in vitro models using planar lipid bilayers have shown that translocation can occur in...
  PubDate: 2013-06-11T09:03:27-07:00
  DOI: 10.1073/pnas.1302257110|hwp:master-id:pnas;1302257110
  Issue No: Vol. 110, No. 24 (2013)
Prefrontal compensation following hippocampal loss [Psychological and Cognitive Sciences]
- Authors: Zelikowsky, M; Bissiere, S, Hast, T. A, Bennett, R. Z, Abdipranoto, A, Vissel, B, Fanselow, M. S.
  Pages: 9938 - 9943
  Abstract: Specific brain circuits have been classically linked to dedicated functions. However, compensation following brain damage suggests that these circuits are capable of dynamic adaptation. Such compensation is exemplified by Pavlovian fear conditioning following damage to the dorsal hippocampus (DH). Although the DH normally underlies contextual fear and fear renewal after...
  PubDate: 2013-06-11T09:03:27-07:00
  DOI: 10.1073/pnas.1301691110|hwp:master-id:pnas;1301691110
  Issue No: Vol. 110, No. 24 (2013)
Emotional contagion in Alzheimer's disease [Neuroscience]
- Authors: Sturm, V. E; Yokoyama, J. S, Seeley, W. W, Kramer, J. H, Miller, B. L, Rankin, K. P.
  Pages: 9944 - 9949
  Abstract: Emotional changes are common in mild cognitive impairment (MCI) and Alzheimer’s disease (AD). Intrinsic connectivity imaging studies suggest that default mode network degradation in AD is accompanied by the release of an emotion-relevant salience network. We investigated whether emotional contagion, an evolutionarily conserved affect-sharing mechanism, is higher in MCI and...
  PubDate: 2013-06-11T09:03:27-07:00
  DOI: 10.1073/pnas.1301119110|hwp:master-id:pnas;1301119110
  Issue No: Vol. 110, No. 24 (2013)
Human brain circadian rhythm altered in depression [Neuroscience]
- Authors: Li, J. Z; Bunney, B. G, Meng, F, Hagenauer, M. H, Walsh, D. M, Vawter, M. P, Evans, S. J, Choudary, P. V, Cartagena, P, Barchas, J. D, Schatzberg, A. F, Jones, E. G, Myers, R. M, Watson, S. J, Akil, H, Bunney, W. E.
  Pages: 9950 - 9955
  Abstract: A cardinal symptom of major depressive disorder (MDD) is the disruption of circadian patterns. However, to date, there is no direct evidence of circadian clock dysregulation in the brains of patients who have MDD. Circadian rhythmicity of gene expression has been observed in animals and peripheral human tissues, but its...
  PubDate: 2013-06-11T09:03:27-07:00
  DOI: 10.1073/pnas.1305814110|hwp:master-id:pnas;1305814110
  Issue No: Vol. 110, No. 24 (2013)
BPA-induced sex-specific epigenetic disruption [Neuroscience]
- Authors: Kundakovic, M; Gudsnuk, K, Franks, B, Madrid, J, Miller, R. L, Perera, F. P, Champagne, F. A.
  Pages: 9956 - 9961
  Abstract: Bisphenol A (BPA) is an estrogenic endocrine disruptor widely used in the production of plastics. Increasing evidence indicates that in utero BPA exposure affects sexual differentiation and behavior; however, the mechanisms underlying these effects are unknown. We hypothesized that BPA may disrupt epigenetic programming of gene expression in the brain....
  PubDate: 2013-06-11T09:03:27-07:00
  DOI: 10.1073/pnas.1214056110|hwp:master-id:pnas;1214056110
  Issue No: Vol. 110, No. 24 (2013)
Deficits in human Down syndrome neurons [Neuroscience]
- Authors: Weick, J. P; Held, D. L, Bonadurer, G. F, Doers, M. E, Liu, Y, Maguire, C, Clark, A, Knackert, J. A, Molinarolo, K, Musser, M, Yao, L, Yin, Y, Lu, J, Zhang, X, Zhang, S.-C, Bhattacharyya, A.
  Pages: 9962 - 9967
  Abstract: Down syndrome (trisomy 21) is the most common genetic cause of intellectual disability, but the precise molecular mechanisms underlying impaired cognition remain unclear. Elucidation of these mechanisms has been hindered by the lack of a model system that contains full trisomy of chromosome 21 (Ts21) in a human genome that...
  PubDate: 2013-06-11T09:03:27-07:00
  DOI: 10.1073/pnas.1216575110|hwp:master-id:pnas;1216575110
  Issue No: Vol. 110, No. 24 (2013)
Serotonin and female sexual preference [Neuroscience]
- Authors: Zhang, S; Liu, Y, Rao, Y.
  Pages: 9968 - 9973
  Abstract: A role for serotonin in male sexual preference was recently uncovered by our finding that male mutant mice lacking serotonin have lost sexual preference. Here we show that female mouse mutants lacking either central serotonergic neurons or serotonin prefer female over male genital odors when given a choice, and displayed...
  PubDate: 2013-06-11T09:03:27-07:00
  DOI: 10.1073/pnas.1220712110|hwp:master-id:pnas;1220712110
  Issue No: Vol. 110, No. 24 (2013)
Role of Neuroligin-1 in wake maintenance [Neuroscience]
- Authors: El Helou, J; Belanger–Nelson, E, Freyburger, M, Dorsaz, S, Curie, T, La Spada, F, Gaudreault, P.–O, Beaumont, E, Pouliot, P, Lesage, F, Frank, M. G, Franken, P, Mongrain, V.
  Pages: 9974 - 9979
  Abstract: Maintaining wakefulness is associated with a progressive increase in the need for sleep. This phenomenon has been linked to changes in synaptic function. The synaptic adhesion molecule Neuroligin-1 (NLG1) controls the activity and synaptic localization of N-methyl-d-aspartate receptors, which activity is impaired by prolonged wakefulness. We here highlight that this...
  PubDate: 2013-06-11T09:03:27-07:00
  DOI: 10.1073/pnas.1221381110|hwp:master-id:pnas;1221381110
  Issue No: Vol. 110, No. 24 (2013)
Tinnitus is a Kv7 chanellopathy [Neuroscience]
- Authors: Li, S; Choi, V, Tzounopoulos, T.
  Pages: 9980 - 9985
  Abstract: Tinnitus, the perception of phantom sound, is often a debilitating condition that affects many millions of people. Little is known, however, about the molecules that participate in the induction of tinnitus. In brain slices containing the dorsal cochlear nucleus, we reveal a tinnitus-specific increase in the spontaneous firing rate of...
  PubDate: 2013-06-11T09:03:27-07:00
  DOI: 10.1073/pnas.1302770110|hwp:master-id:pnas;1302770110
  Issue No: Vol. 110, No. 24 (2013)
Proteasomal overload in retinal degeneration [Neuroscience]
- Authors: Lobanova, E. S; Finkelstein, S, Skiba, N. P, Arshavsky, V. Y.
  Pages: 9986 - 9991
  Abstract: Inherited retinal degenerations, caused by mutations in over 100 individual genes, affect approximately 2 million people worldwide. Many of the underlying mutations cause protein misfolding or mistargeting in affected photoreceptors. This places an increased burden on the protein folding and degradation machinery, which may trigger cell death. We analyzed how...
  PubDate: 2013-06-11T09:03:27-07:00
  DOI: 10.1073/pnas.1305521110|hwp:master-id:pnas;1305521110
  Issue No: Vol. 110, No. 24 (2013)
Potent kinetic stabilizer of transthyretin [Pharmacology]
- Authors: Penchala, S. C; Connelly, S, Wang, Y, Park, M. S, Zhao, L, Baranczak, A, Rappley, I, Vogel, H, Liedtke, M, Witteles, R. M, Powers, E. T, Reixach, N, Chan, W. K, Wilson, I. A, Kelly, J. W, Graef, I. A, Alhamadsheh, M. M.
  Pages: 9992 - 9997
  Abstract: The misassembly of soluble proteins into toxic aggregates, including amyloid fibrils, underlies a large number of human degenerative diseases. Cardiac amyloidoses, which are most commonly caused by aggregation of Ig light chains or transthyretin (TTR) in the cardiac interstitium and conducting system, represent an important and often underdiagnosed cause of...
  PubDate: 2013-06-11T09:03:28-07:00
  DOI: 10.1073/pnas.1300761110|hwp:master-id:pnas;1300761110
  Issue No: Vol. 110, No. 24 (2013)
Kidney sulfatides and renal acid-base regulation [Physiology]
- Authors: Stettner, P; Bourgeois, S, Marsching, C, Traykova–Brauch, M, Porubsky, S, Nordstrom, V, Hopf, C, Kosters, R, Sandhoff, R, Wiegandt, H, Wagner, C. A, Grone, H.–J, Jennemann, R.
  Pages: 9998 - 10003
  Abstract: Urinary ammonium excretion by the kidney is essential for renal excretion of sufficient amounts of protons and to maintain stable blood pH. Ammonium secretion by the collecting duct epithelia accounts for the majority of urinary ammonium; it is driven by an interstitium-to-lumen NH3 gradient due to the accumulation of ammonium...
  PubDate: 2013-06-11T09:03:28-07:00
  DOI: 10.1073/pnas.1217775110|hwp:master-id:pnas;1217775110
  Issue No: Vol. 110, No. 24 (2013)
NHA2 and insulin secretion [Physiology]
- Authors: Deisl, C; Simonin, A, Anderegg, M, Albano, G, Kovacs, G, Ackermann, D, Moch, H, Dolci, W, Thorens, B, A. Hediger, M, Fuster, D. G.
  Pages: 10004 - 10009
  Abstract: NHA2 is a sodium/hydrogen exchanger with unknown physiological function. Here we show that NHA2 is present in rodent and human β-cells, as well as β-cell lines. In vivo, two different strains of NHA2-deficient mice displayed a pathological glucose tolerance with impaired insulin secretion but normal peripheral insulin sensitivity. In vitro,...
  PubDate: 2013-06-11T09:03:28-07:00
  DOI: 10.1073/pnas.1220009110|hwp:master-id:pnas;1220009110
  Issue No: Vol. 110, No. 24 (2013)
SOBIR1 interacts with RLPs in plant immunity [Plant Biology]
- Authors: Liebrand, T. W. H; van den Berg, G. C. M, Zhang, Z, Smit, P, Cordewener, J. H. G, America, A. H. P, Sklenar, J, Jones, A. M. E, Tameling, W. I. L, Robatzek, S, Thomma, B. P. H. J, Joosten, M. H. A. J.
  Pages: 10010 - 10015
  Abstract: The plant immune system is activated by microbial patterns that are detected as nonself molecules. Such patterns are recognized by immune receptors that are cytoplasmic or localized at the plasma membrane. Cell surface receptors are represented by receptor-like kinases (RLKs) that frequently contain extracellular leucine-rich repeats and an intracellular kinase...
  PubDate: 2013-06-11T09:03:28-07:00
  DOI: 10.1073/pnas.1220015110|hwp:master-id:pnas;1220015110
  Issue No: Vol. 110, No. 24 (2013)
Isolation of NPQ supercomplex in Chlamydomonas [Plant Biology]
- Authors: Tokutsu, R; Minagawa, J.
  Pages: 10016 - 10021
  Abstract: Plants and green algae have a low pH-inducible mechanism in photosystem II (PSII) that dissipates excess light energy, measured as the nonphotochemical quenching of chlorophyll fluorescence (qE). Recently, nonphotochemical quenching 4 (npq4), a mutant strain of the green alga Chlamydomonas reinhardtii that is qE-deficient and lacks the light-harvesting complex stress-related...
  PubDate: 2013-06-11T09:03:28-07:00
  DOI: 10.1073/pnas.1222606110|hwp:master-id:pnas;1222606110
  Issue No: Vol. 110, No. 24 (2013)
Crystal structure of the FRP [Plant Biology]
- Authors: Sutter, M; Wilson, A, Leverenz, R. L, Lopez-Igual, R, Thurotte, A, Salmeen, A. E, Kirilovsky, D, Kerfeld, C. A.
  Pages: 10022 - 10027
  Abstract: Photosynthetic reaction centers are sensitive to high light conditions, which can cause damage because of the formation of reactive oxygen species. To prevent high-light induced damage, cyanobacteria have developed photoprotective mechanisms. One involves a photoactive carotenoid protein that decreases the transfer of excess energy to the reaction centers. This protein,...
  PubDate: 2013-06-11T09:03:28-07:00
  DOI: 10.1073/pnas.1303673110|hwp:master-id:pnas;1303673110
  Issue No: Vol. 110, No. 24 (2013)
SCFKMD controls cytokinin signaling [Plant Biology]
- Authors: Kim, H. J; Chiang, Y.-H, Kieber, J. J, Schaller, G. E.
  Pages: 10028 - 10033
  Abstract: Cytokinins are plant hormones that play critical roles in growth and development. In Arabidopsis, the transcriptional response to cytokinin is regulated by action of type-B Arabidopsis response regulators (ARRs). Although central elements in the cytokinin signal transduction pathway have been identified, mechanisms controlling output remain to be elucidated. Here we...
  PubDate: 2013-06-11T09:03:28-07:00
  DOI: 10.1073/pnas.1300403110|hwp:master-id:pnas;1300403110
  Issue No: Vol. 110, No. 24 (2013)
Perceptual basis of music styles [Applied Mathematics]
- Authors: Rodriguez Zivic, P. H; Shifres, F, Cecchi, G. A.
  Pages: 10034 - 10038
  Abstract: The brain processes temporal statistics to predict future events and to categorize perceptual objects. These statistics, called expectancies, are found in music perception, and they span a variety of different features and time scales. Specifically, there is evidence that music perception involves strong expectancies regarding the distribution of a melodic...
  PubDate: 2013-06-11T09:03:28-07:00
  DOI: 10.1073/pnas.1222336110|hwp:master-id:pnas;1222336110
  Issue No: Vol. 110, No. 24 (2013)
Tradeoffs in glycolytic strategy [Systems Biology]
- Authors: Flamholz, A; Noor, E, Bar-Even, A, Liebermeister, W, Milo, R.
  Pages: 10039 - 10044
  Abstract: Contrary to the textbook portrayal of glycolysis as a single pathway conserved across all domains of life, not all sugar-consuming organisms use the canonical Embden–Meyerhoff–Parnass (EMP) glycolytic pathway. Prokaryotic glucose metabolism is particularly diverse, including several alternative glycolytic pathways, the most common of which is the Entner–Doudoroff (ED) pathway. The...
  PubDate: 2013-06-11T09:03:28-07:00
  DOI: 10.1073/pnas.1215283110|hwp:master-id:pnas;1215283110
  Issue No: Vol. 110, No. 24 (2013)
Correction for Shinohara et al., Left-right asymmetry of the hippocampal synapses with differential subunit allocation of glutamate receptors [Corrections]
- Pages: 10045 - 10046
  Abstract: NEUROSCIENCE Correction for “Left-right asymmetry of the hippocampal synapses with differential subunit allocation of glutamate receptors,” by Yoshiaki Shinohara, Hajime Hirase, Masahiko Watanabe, Makoto Itakura, Masami Takahashi, and Ryuichi Shigemoto, which appeared in issue 49, December 9, 2008, of Proc Natl Acad Sci USA (105:19498–19503; first published December 3, 2008;...
  PubDate: 2013-06-11T09:03:28-07:00
  DOI: 10.1073/pnas.1309461110|hwp:master-id:pnas;1309461110
  Issue No: Vol. 110, No. 24 (2013)