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LABORATORY AND EXPERIMENTAL MEDICINE (99 journals)

Showing 1 - 99 of 99 Journals sorted alphabetically
AAPS PharmSciTech     Hybrid Journal   (Followers: 9)
Actualites Pharmaceutiques     Full-text available via subscription   (Followers: 7)
Adipocyte     Open Access   (Followers: 1)
African Journal of Laboratory Medicine     Open Access   (Followers: 2)
American Journal of Experimental and Clinical Research     Open Access   (Followers: 4)
American Journal of Medical and Biological Research     Open Access   (Followers: 10)
Animal Models and Experimental Medicine     Open Access  
Annals of Clinical Chemistry and Laboratory Medicine     Open Access   (Followers: 5)
Applied In Vitro Toxicology     Hybrid Journal   (Followers: 2)
Archives of Clinical and Experimental Medicine     Open Access  
Archives of Medical Research     Hybrid Journal   (Followers: 3)
Archives of Pathology & Laboratory Medicine     Full-text available via subscription   (Followers: 31)
Archives of Preventive Medicine     Open Access   (Followers: 3)
Biomedical Engineering     Hybrid Journal   (Followers: 3)
Bulletin of Experimental Biology and Medicine     Hybrid Journal  
Clinica Chimica Acta     Hybrid Journal   (Followers: 30)
Clinical & Experimental Metastasis     Hybrid Journal  
Clinical and Experimental Medical Journal     Full-text available via subscription   (Followers: 1)
Clinical and Experimental Medicine     Hybrid Journal   (Followers: 4)
Clinical Trials     Hybrid Journal   (Followers: 21)
Clinical Trials in Degenerative Diseases     Open Access  
Clinical Trials in Orthopedic Disorders     Open Access   (Followers: 1)
Current Medicine Research and Practice     Full-text available via subscription  
Current Research in Drug Discovery     Open Access   (Followers: 1)
Drug Design, Development and Therapy     Open Access   (Followers: 4)
Ecography     Hybrid Journal   (Followers: 28)
European Journal of Hospital Pharmacy : Science and Practice (EJHP)     Hybrid Journal   (Followers: 8)
European Journal of Medical Research     Open Access   (Followers: 1)
European Journal of Nanomedicine     Hybrid Journal   (Followers: 1)
Experimental & Molecular Medicine     Open Access   (Followers: 1)
Experimental Aging Research: An International Journal Devoted to the Scientific Study of the Aging Process     Hybrid Journal   (Followers: 3)
Experimental and Therapeutic Medicine     Full-text available via subscription   (Followers: 1)
Experimental Biology and Medicine     Hybrid Journal   (Followers: 3)
Expert Opinion on Drug Delivery     Hybrid Journal   (Followers: 20)
Frontiers in Laboratory Medicine     Open Access  
Frontiers in Medical Technology     Open Access   (Followers: 1)
IN VIVO     Full-text available via subscription   (Followers: 5)
International Archives of Biomedical and Clinical Research     Open Access  
International Journal of Experimental Pathology     Hybrid Journal   (Followers: 1)
International Journal of Health Research and Innovation     Open Access   (Followers: 1)
International Journal of Research in Medical Sciences     Open Access   (Followers: 5)
International Journal of Statistics in Medical Research     Hybrid Journal   (Followers: 5)
Journal of Cell Science & Therapy     Open Access   (Followers: 1)
Journal of Applied Biomaterials & Functional Materials     Hybrid Journal   (Followers: 1)
Journal of Biomedical and Clinical Research     Open Access  
Journal of Clinical Laboratory Analysis     Open Access   (Followers: 14)
Journal of Clinical Medicine and Research     Open Access  
Journal of Clinical Medicine Research     Open Access   (Followers: 4)
Journal of Clinical Trials     Open Access   (Followers: 6)
Journal of Current and Advance Medical Research     Open Access   (Followers: 1)
Journal of Current Medical Research and Practice     Open Access  
Journal of Current Research in Scientific Medicine     Open Access  
Journal of Current Researches on Health Sector     Open Access  
Journal of Drug Delivery and Therapeutics JDDT     Open Access   (Followers: 1)
Journal of Enzyme Inhibition and Medicinal Chemistry     Open Access   (Followers: 4)
Journal of Experimental & Clinical Medicine     Full-text available via subscription   (Followers: 1)
Journal of Experimental & Clinical Cancer Research     Open Access   (Followers: 2)
Journal of Experimental and Clinical Medicine     Open Access  
Journal of Experimental Medicine     Full-text available via subscription   (Followers: 45)
Journal of Experimental Pharmacology     Open Access   (Followers: 2)
Journal of Histotechnology     Hybrid Journal   (Followers: 2)
Journal of International Medical Research     Open Access   (Followers: 3)
Journal of Investigative Medicine High Impact Case Reports     Open Access  
Journal of Medicine and Biomedical Research     Open Access   (Followers: 1)
Journal of Muhammadiyah Medical Laboratory Technologist     Open Access  
Journal of Operating Department Practitioners     Full-text available via subscription   (Followers: 2)
Journal of the American Society of Cytopathology     Hybrid Journal   (Followers: 6)
Journal of Trace Elements in Medicine and Biology     Hybrid Journal   (Followers: 1)
Lab on a Chip     Full-text available via subscription   (Followers: 42)
Laboratory Investigation     Hybrid Journal   (Followers: 3)
Medical Devices & Sensors     Hybrid Journal  
Medical Image Analysis     Hybrid Journal   (Followers: 15)
Medical Instrumentation     Open Access  
Medical Laboratory Observer     Full-text available via subscription  
Medical Laboratory Technology Journal     Open Access  
Medicinal Chemistry Research     Hybrid Journal   (Followers: 12)
Medtech Insight     Full-text available via subscription   (Followers: 4)
Nanomedicine: Nanotechnology, Biology and Medicine     Hybrid Journal   (Followers: 7)
New Zealand Journal of Medical Laboratory Science     Full-text available via subscription   (Followers: 1)
Oriental Pharmacy and Experimental Medicine     Partially Free   (Followers: 3)
Pathology and Laboratory Medicine International     Open Access   (Followers: 7)
Physical Biology     Hybrid Journal   (Followers: 4)
Practical Laboratory Medicine     Open Access   (Followers: 2)
Proceedings of the Institution of Mechanical Engineers Part H: Journal of Engineering in Medicine     Hybrid Journal   (Followers: 3)
Prosthetics and Orthotics International     Hybrid Journal   (Followers: 9)
Pulse     Full-text available via subscription  
Qualitative Research in Medicine & Healthcare     Open Access  
Recent Advances in Biology and Medicine     Open Access  
Regulatory Toxicology and Pharmacology     Hybrid Journal   (Followers: 43)
Reproduction     Full-text available via subscription   (Followers: 7)
Revista Peruana de Medicina Experimental y Salud Pública     Open Access  
Revista Romana de Medicina de Laborator     Open Access  
RSC Medicinal Chemistry     Full-text available via subscription   (Followers: 6)
SA Pharmacist's Assistant     Open Access  
Savannah Journal of Medical Research and Practice     Full-text available via subscription  
SLAS Technology     Hybrid Journal   (Followers: 2)
Statistics in Medicine     Hybrid Journal   (Followers: 190)
Trends in Molecular Medicine     Full-text available via subscription   (Followers: 14)
Turkish Journal of Clinics and Laboratory     Open Access   (Followers: 1)
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Journal Cover
Journal of Trace Elements in Medicine and Biology
Journal Prestige (SJR): 0.932
Citation Impact (citeScore): 4
Number of Followers: 1  
 
  Hybrid Journal Hybrid journal (It can contain Open Access articles)
ISSN (Print) 0946-672X - ISSN (Online) 1878-3252
Published by Elsevier Homepage  [3201 journals]
  • Titanium dioxide nanoparticles induce endothelial cell apoptosis via cell
           membrane oxidative damage and p38, PI3K/Akt, NF-κB signaling pathways
           modulation
    • Abstract: Publication date: July 2019Source: Journal of Trace Elements in Medicine and Biology, Volume 54Author(s): Zafar Gholinejad, Mohammad Hasan Khadem Ansari, Yousef Rasmi BackgroundTitanium dioxide nanoparticles (TiO2 NPs) are widely used nanoparticles. Despite, several studies investigated the toxic effects of TiO2 NPs on HUVECs, the results are contradictory and the possible underlying mechanisms remain unclear.MethodsIn the present study, we conducted an in vitro study to re-evaluate the possible toxic effects of TiO2 NPs on HUVECs including cell viability, lipids peroxidation, intracellular signaling pathways and nitric oxide syntheses enzymes.ResultsOur results demonstrated that, TiO2 NPs were internalized to HUVECs and induce intracellular reactive oxygen species production and cell membrane oxidative damage at the higher concentration. TiO2 NPs induce IKKα/β and Akt phosphorylation and p38 dephosphorylation. After 24 h treatment, pro-inflammatory cytokines, adhesion molecules and chemokine upregulated significantly. TiO2 NPs have no significant effects on eNOS enzymatic activation and iNOS gene expression. At cellular level, apoptosis is the main process that occur in response to TiO2 NPs treatment. HUVECs pretreatment with N-acetyl-l-cysteine (NAC) ameliorate the toxic effects of TiO2 NPs that indicate the oxidative stress is essential in TiO2 NPs -induced toxicity. Total antioxidant capacity show a trend to increase in response to TiO2 NPs exposure.ConclusionsTaken together, this study confirmed the effects of TiO2 NPs on endothelial cells and proposed multiple underlying mechanisms including cell membrane oxidative damage and intracellular processes.Graphical abstractGraphical abstract for this article
       
  • A urinary metabolomics study of a Polish subpopulation environmentally
           exposed to arsenic
    • Abstract: Publication date: Available online 1 April 2019Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): Lucyna Kozłowska, Beata Janasik, Katarzyna Nowicka, Wojciech WąsowiczGraphical abstractGraphical abstract for this article
       
  • Enhanced antibacterial activity of hemocyanin purified from Portunus
           pelagicus hemolymph combined with silver nanoparticles – Intracellular
           uptake and mode of action
    • Abstract: Publication date: July 2019Source: Journal of Trace Elements in Medicine and Biology, Volume 54Author(s): Ramachandran Ishwarya, Baskaralingam Vaseeharan, Sivakumar Shanthini, Marimuthu Govindarajan, Naiyf S. Alharbi, Shine Kadaikunnan, Jamal M. Khaled, Mohammed N. Al-anbr Recently, biogenic nanoparticles have been considered promising candidates for manufacturing antibacterial nanodrugs. Here, we synthesized AgNPs using the crab-borne antibacterial agent hemocyanin and assessed the antibacterial action against several pathogenic bacteria. In this study, the crustacean immune protein hemocyanin (Pp-Hc, 78 kDa) purified from Portunus pelagicus hemolymph was used to fabricate silver nanoparticles. Characterization of hemocyanin-fabricated AgNPs (Pp-Hc AgNPs) were achieved using ultraviolet-visible spectrophotometer, X-ray powder diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), high-resolution-transmission electron microscopy (HR-TEM), and energy-dispersive X-ray spectroscopy. The antibacterial efficacy of AgNO3, Pp-Hc and Pp-Hc AgNPs was compared by growth inhibition, antibiofilm and live and dead analyses. Based on the results, Pp-Hc AgNPs was more efficient than Pp-Hc and AgNO3 against pathogenic bacteria. Mechanistic analysis revealed membrane damage and reactive oxygen species (ROS) generation, suggesting that Pp-Hc and Pp-Hc AgNPs rely to similar modes of action. Intracellular protein molecules and nucleic acid leakage confirmed that Pp-Hc AgNPs increase membrane permeability, leading to cell death. Based on our results, capping of the exterior surface of nanoparticles with antimicrobial crab-borne peptides, such as Pp-Hc, improves their functions as potential agents against bacterial diseases, which may be useful in clinical applications.Graphical abstractGraphical abstract for this article
       
  • Comparison of aqueous and enzymatic extraction combination with sequential
           filtration for the profiling of selected trace elements in medicinal
           plants from Kenya
    • Abstract: Publication date: July 2019Source: Journal of Trace Elements in Medicine and Biology, Volume 54Author(s): R. Mogwasi, D.K. Kariuki, M.Z. Getenga, V. Nischwitz This work presents results for the profiling of eight essential elements (Co, Cu, Ni, V, Mo, Mn, Zn and Cr) in aqueous and enzymatic extracts of eight anti-diabetic medicinal plants, used by Traditional Medicine Practitioners from Nyamira County, Kenya determined by ICP-MS. The plants used in the study were Solanum indicum, Plectranthus barbatus, Ultrica dioica, Bidens pilosa, Solanum mauense, Clerodendrum myricoides, Carissa edulis and Aloe vera. A sequential filtration procedure was applied to fractionate the elemental contents of the obtained aqueous extracts into molecular size fractions. The results indicate that the low molecular size species (
       
  • The toxicological analysis of Cu, Mn and Zn as elemental impurities in
           pharmaceutical herbal products for teething available in pharmacies in
           Poland
    • Abstract: Publication date: May 2019Source: Journal of Trace Elements in Medicine and Biology, Volume 53Author(s): Kamil Jurowski, Mirosław Krośniak, Maria Fołta, Barbara Tatar, Michael Cole, Wojciech Piekoszewski The monitoring of elemental impurities (EIs) in pharmaceutical materials is often not adequately treated, although it is a very important topic because the directive ICH Q3D requires a wide range of elements, often at low concentrations, to be monitored. This article describes the quantitative toxicological analysis of copper, manganese and zinc as EIs in the pharmaceutical gels for teething containing herbs available in Poland. The levels of EIs were measured to evaluate whether the intake of these metals through the gels was within recommended levels. The flame absorption spectrometry (FAAS) following microwave induced digestion (concentrated nitric acid) was applied to determine the levels of Cu, Mn and Zn in the products. This article was motivated especially by the facts that: (i) herbs can be a potential source of EIs; (ii) Cu, Mn and Zn are essential trace elements in the infancy period; (iii) there is a general lack of data around the risk assessment associated with exposure to these EIs in this kind of pharmaceutical. Our safety assessment is based on triple approach including: (1) profile of EIs in gels; (2) the actual amount of EIs in the appropriate amount of gel applied with a single administration (one drop) and (3) the daily exposure of EIs in analysed teething pharmaceuticals due to the maximum daily dose. Our results show that all EI levels meet the standards of directive ICH Q3D. It can be concluded that all of the teething gels investigated, based on herbs, available in Polish pharmacies do not represents a health hazard to babies.Graphical abstractGraphical abstract for this article
       
  • Sex-specific effects of blood cadmium on thyroid hormones and thyroid
           function status: Korean nationwide cross-sectional study
    • Abstract: Publication date: May 2019Source: Journal of Trace Elements in Medicine and Biology, Volume 53Author(s): Seung Min Chung, Jun Sung Moon, Ji Sung Yoon, Kyu Chang Won, Hyoung Woo Lee Previous studies on blood cadmium (BCd) and changes in thyroid hormone levels are controversial. We investigated whether thyroid hormone levels and thyroid function status were associated with BCd according to sex in the Korean population. Our study included 1972 participants based on the 2013 Korea National Health and Nutrition Examination Survey (KNHANES) data. Participants whose thyroid-stimulating hormone (TSH) and free thyroxine (fT4) levels were altered physiologically or medically were excluded. Changes in TSH, fT4, and anti-thyroid peroxidase antibody (TPOAb) in men and women were analyzed by different characteristics: age, body mass index (BMI), smoking status, drinking status, BCd, and urine iodine-to-creatinine ratio (UI/Cre). Thyroid function status was classified as hypothyroidism, euthyroidism, and hyperthyroidism as defined by TSH and fT4 levels. Among the total participants, there was a negative correlation between BCd and fT4 (r=-0.067, p = 0.003). In men (n = 1057), fT4 levels decreased with increasing BCd quartile (p-for-trend = 0.002). After adjustment for age, BMI, smoking status, UI/Cre, and TPOAb, the association between BCd and hypothyroidism was significant in men (odds ratio = 1.813, p = 0.032) but not in women. These results suggest that cadmium accumulation is closely associated with thyroid dysfunction, and there is a difference in metabolic capacity according to sex.
       
  • Organoselenotriazoles attenuate oxidative damage induced by mitochondrial
           dysfunction in mev-1 Caenorhabditis elegans mutants
    • Abstract: Publication date: May 2019Source: Journal of Trace Elements in Medicine and Biology, Volume 53Author(s): Ana Thalita Gonçalves Soares, Luiz Brasil Lopes Rodrigues, Willian Goulart Salgueiro, Ana Helena de Castro Dal Forno, Cristiane Freitas Rodrigues, Manoela Sacramento, Jeferson Franco, Diego Alves, Riva de Paula Oliveira, Simone Pinton, Daiana S. Ávila Organic selenium compounds have several pharmacological activities already described, as anti-inflammatory and antitumor activities, which have been attributed to their antioxidant effects. Because they are promising in pharmacology, the synthesis of these compounds has increased significantly. As many new molecules are synthesized the use of a simple model like Caenorhabditis elegans is highly advantageous for initial evaluation of the toxicity and therapeutic potential of these molecules. The objective of this study was to evaluate the toxicity and antioxidant capacity of a series of selenotriazoles compounds in C. elegans. The animals were exposed to the compounds in liquid medium for only 30 min at the first larval stage (L1). The compounds had no toxic effects at the concentrations tested. Treatment with selenotriazoles (10 μM) partially reversed the stress induced by the pesticide paraquat (1 mM). Se-Tz Ia compound partially increased the survival of worms treated with H2O2 (0.5 mM). The compounds also increased the longevity of mev-1 mutants, which have a reduced life span by the production of excessive reactive oxygen species (ROS) in the mitochondria caused by a mutation in complex II of the electron transport chain. In addition, the compounds reduced the levels of ROS determined by the fluorescent probe DCF-DA as well as also reduced catalase enzyme activity in these animals. Based on the results found, it is possible to conclude that the compounds have antioxidant activity mainly in oxidative stress condition generated by a mitochondrial dysfunction in C. elegans.
       
  • Sex-dependent expression of metallothioneins MT1 and MT2 and
           concentrations of trace elements in rat liver and kidney tissues: Effect
           of gonadectomy
    • Abstract: Publication date: May 2019Source: Journal of Trace Elements in Medicine and Biology, Volume 53Author(s): Marija Ljubojević, Tatjana Orct, Vedran Micek, Dean Karaica, Jasna Jurasović, Davorka Breljak, Ivana Vrhovac Madunić, Dubravka Rašić, Ivana Novak Jovanović, Maja Peraica, Marko Gerić, Goran Gajski, Saša Kralik Oguić, Dunja Rogić, Lucia Nanić, Ivica Rubelj, Ivan Sabolić Metallothioneins (MTs) exhibit binding affinity for several essential and toxic trace elements. Previous studies in rodents indicated sex differences in the hepatic and renal expression of MTs and concentrations of various elements. The mechanism responsible for these differences has not been resolved. Here, in the liver and kidney tissues of sham-operated and gonadectomized male and female rats we determined the expression of MT1 and MT2 (MT1&2) mRNA by RT-PCR, abundance of MT1&2 proteins by Western blotting and immunocytochemistry, concentrations of essential (Fe, Zn, Cu, Co) and toxic (Cd, Hg, Pb) elements by ICP-MS, and oxidative status parameters (SOD, GPx, MDA, GSH) by biochemical methods. In both organs, the expression of MT1&2 mRNA and MT1&2 proteins was female-dominant, upregulated by castration, and downregulated by ovariectomy. Concentrations of Fe in the liver and Co in the kidneys followed the same pattern. Most other elements (Zn, Cu, Cd, Hg) exhibited female- or male-dominant sex differences, affected by gonadectomy in one or both organs. Pb was sex- and gonadectomy-unaffected. GPx and MDA were elevated and associated with the highest concentrations of Fe only in the female liver. We conclude that the sex-dependent expression of MT1&2 mRNA and proteins in the rat liver and kidneys may include different mechanisms. In the liver, the female-dominant tissue concentrations of Fe may generate oxidative stress which is a potent enhancer of MTs production, whereas in kidneys, the female-dominant expression of MTs may be unrelated to Fe-mediated oxidative stress.
       
  • The combined effects of Cr(III) propionate complex supplementation and
           iron excess on copper and zinc status in rats
    • Abstract: Publication date: May 2019Source: Journal of Trace Elements in Medicine and Biology, Volume 53Author(s): Halina Staniek It is suggested that both iron overload and chromium(III) deficiency may be risk factors of diabetes. It seems that both Fe and Cr(III) metabolism as well as copper and zinc metabolism are interrelated. However, the direction of these changes may depend on mutual proportions of these elements in the diet and organism. The aim of the study was to evaluate the combined effects of Cr(III) supplementation with Fe excess on the Cu and Zn status in female rats. Thirty-six healthy rats were divided into 6 experimental groups with different Fe levels in the diet. Groups marked with C (control) contained Fe at the recommended level (45 mg kg−1). The excess groups (E) contained Fe at 180 mg kg−1. At the same time the animals were supplemented with Cr(III) of doses 1, 50 and 500 mg kg−1 of diet. The Cr, Fe, Cu and Zn dietary and tissular contents were measured with the AAS method.The excess Fe in the diet significantly decreased the Cu content in the liver and kidneys, but it increased the spleen Cu level. The Cr(III) supplementary did not affect the tissular Cu levels, regardless of Fe supply with diet. The experimental factors did not have significant interactional effect on the Cu status parameters under study.The Fe excess in the diet reduced the renal and splenic Zn content, but increased the heart Zn content. The Cr(III) supplementation decreased the Zn content in the kidneys. The Zn content in the liver and spleen tended to decrease as the Cr(III) supply in the diet increased. There was no significant interactional effect of Cr(III) supplementation and the Fe excessive supply in diet on the parameters of Zn metabolism in Wistar rats.Iron oversupply disturbed the rat's Cu and Zn status. However, Cr(III) supplementation did not affect the tissular levels of these elements, except the kidney Zn content. Simultaneous supplementation with the Cr(III) propionate complex did not deepen changes in tissular Cu and Zn levels caused by the Fe excess in the diet.
       
  • Rutin abrogates manganese—Induced striatal and hippocampal toxicity via
           inhibition of iron depletion, oxidative stress, inflammation and
           suppressing the NF-κB signaling pathway
    • Abstract: Publication date: May 2019Source: Journal of Trace Elements in Medicine and Biology, Volume 53Author(s): Kpobari W. Nkpaa, Godspower I. Onyeso, Kale Z. Kponee Excess exposure to Manganese (Mn) promotes oxidative stress and neuro-inflammation. Rutin (RUT) has been found to exhibit both anti-oxidative stress and anti-inflammatory properties. This study aimed to investigate the effects of RUT on Mn accumulation, endogenous iron (Fe) depletion, oxidative stress, inflammation and nuclear factor kappa B (NF-κB) signaling pathways in the hippocampus and striatum of Mn – induced rats. Rats were treated with 30 mg/kg Mn body weight alone or orally co-treated by gavage with RUT at 50 and at 100 mg/kg body weight for 35 consecutive days. Thereafter, we investigated Mn and endogenous Fe levels, acetylcholinesterase activity, oxidative stress markers, pro-inflammatory cytokines and nuclear factor kappa B (NF-κB) in the hippocampus and striatum of rats. The results indicate that Mn induced Mn – accumulation, Fe depletion, oxidative stress, inflammation and the activation of acetylcholinesterase activity and NF-κB signaling pathways in the hippocampus and striatum of the rats. However, RUT attenuated Fe depletion, oxidative stress and inflammation and suppressed acetylcholinesterase activity and NF-κB pathway via downstream regulations of tumor necrosis factor alpha, interleukin I beta and interleukin 6. Taken together, our present study demonstrates that RUT abrogates Mn – induced striatal and hippocampal toxicity via inhibition of Fe depletion, oxidative stress, inflammation and suppressing the NF-κB signaling pathways. Our results indicate that RUT may be of use as a neuroprotective agent against Mn – induced neuronal toxicity.
       
  • Chronic copper treatment prevents the liver critical balance transcription
           response induced by acetaminophen
    • Abstract: Publication date: May 2019Source: Journal of Trace Elements in Medicine and Biology, Volume 53Author(s): Mauricio Latorre, Jason L. Burkhead, Christian Hodar, Miguel Arredondo, Mauricio González, Magdalena Araya The independent toxic effects of copper and acetaminophen are among the most studied topics in liver toxicity. Here, in an animal model of Cebus capucinus chronically exposed to high dietary copper, we assessed clinical and global transcriptional adaptations of the liver induced by a single high dose of acetaminophen. The experiment conditions were chosen to resemble a close to human real-life situation of exposure to both toxic stimuli. The clinical parameters and histological analyses indicated that chronic copper administration does not induce liver damage and may have a protective effect in acetaminophen challenge. Acetaminophen administration in previously non-exposed animals induced down-regulation of a complex network of gene regulators, highlighting the putative participation of the families of gene regulators HNF, FOX, PPAR and NRF controlling this process. This gene response was not observed in animals that previously received chronic oral copper, suggesting that this metal induces a transcriptional adaptation that may protect against acetaminophen toxicity, a classical adaptation response termed preconditioning of the liver.
       
  • Zebrafish exposure to diphenyl diselenide-loaded polymeric nanocapsules
           caused no behavioral impairments and brain oxidative stress
    • Abstract: Publication date: May 2019Source: Journal of Trace Elements in Medicine and Biology, Volume 53Author(s): Luana Mota Ferreira, Luiz Vinícius Costa da Rosa, Talise Ellwanger Müller, Charlene Cavalheiro de Menezes, Marcel Henrique Marcondes Sari, Vania Lucia Loro, Cristina Wayne Nogueira, Denis Broock Rosemberg, Letícia Cruz Previous findings showed that the nanoencapsulation of diphenyl diselenide [(PhSe)2], an organoselenium compound, provided superior biological effects and lower toxicological potential than its free form in vitro. However, few studies reported the behavioral and biochemical effects of this nanocapsules formulation in vivo. Zebrafish (Danio rerio) has emerged as a useful animal model to determine the pharmacological and toxicological effects of nanoparticles. Here, we evaluated the behavioral and brain oxidative effects after zebrafish exposure to (PhSe)2-loaded nanocapsules. Formulations were prepared by interfacial deposition of preformed polymer method and later tested at concentrations ranging from 0.1 to 2.0 μM. Both locomotor and exploratory activities were assessed in the novel tank diving test. Moreover, brain oxidative status was determined by measuring thiobarbituric acid-reactive substance levels, glutathione peroxidase, glutathione redutase and glutathione S-transferase activities. (PhSe)2-loaded nanocapsules showed no alteration on travelled distance, immobility, and erratic swimming, suggesting the absence of behavioral impairments. Interestingly, the higher concentration tested had anxiolytic-like effects, since animals spent more time in the top area and showed a decreased thigmotaxis behavior. Biochemical analysis demonstrated that the concentrations used in this study did not affect oxidative stress-related parameters in brain samples, reinforcing the low toxicological potential of the formulation. In conclusion, the exposure to (PhSe)2-loaded nanocapsules caused no locomotor impairments as well as did not modify the oxidative status of zebrafish brain, indicating that this formulation is probably non-toxic and promising for future pharmacological studies.
       
  • Hepato-preventive and anti-apoptotic role of boric acid against liver
           injury induced by cyclophosphamide
    • Abstract: Publication date: May 2019Source: Journal of Trace Elements in Medicine and Biology, Volume 53Author(s): Mustafa Cengiz, Songul Cetik Yildiz, Cemil Demir, İlknur Kulcanay Şahin, Özgün Teksoy, Adnan Ayhanci This study aims to examine cyclophosphamide (CP) exsposure associated toxicity on rat livers and the likely defensive effects of boric acid (BA). The rats used in this study were divided into four groups: control group, CP group, BA group, and BA + CP group. The present study was carried out using routine histological H&E stain, immunohistochemical stain caspase-3 as apoptotic marker, serum biochemical analysis for liver function markers (alanine transaminase (ALT), aspartate transaminase (AST) and alkalen phosphatase (ALP)), oxidative stress markers (total oxidant status (TOS), oxidative stress index (OSI) and total antioxidant capacity marker (TAC)). In the CP group, the levels of ALT, AST, ALP, TOS, OSI and caspase-3 increased whereas TAC levels decreased compared with the control group. In the BA + CP group, the levels of ALT, AST, ALP, TOS, OSI and caspase-3 decreased whereas TAC levels increased compared with the CP group. The histopathological evaluation of light microscope images and immunohistochemical caspase-3 activity in the BA + CP group were found to be decrease compared with those in the CP group. In conclusion, BA was successful in defending the liver against apoptosis and histopathological changes that are attributable to CP.
       
  • Boron and pigment content in alfalfa affected by nano fertilization under
           calcareous conditions
    • Abstract: Publication date: May 2019Source: Journal of Trace Elements in Medicine and Biology, Volume 53Author(s): Maryam Taherian, Amir Bostani, Heshmat Omidi Boron is among the necessary nutrients for plant growth and yield production, and it can improve the nutritional properties of forage crops. However, at higher levels it maybe toxic adversely affecting plant growth and forage quality. Plant boron concentration is affected by different parameters including boron fertilization, soil, climate, plant species, etc. A new era in the field of plant fertilization is the use of nano technology. Accordingly, a factorial field experiment on the basis of a complete block design in six replicates was conducted in a 300-hactare agro-industry area. The objectives were to investigate the effects of different boron treatments on alfalfa (Medicago sativa L.): 1) boron concentration, and 2) pigment contents including chlorophyll a, b, total, and carotenoids. Six regions with different properties were selected for the experiment; the soil samples were collected using GPS. The experimental treatments including: 1) soil type (S1-S6), 2) boron sources including boric acid (B1) and nano boron fertilization (B2), and 3) number of spraying (zero-, one-, two-, and three-time) were tested. The nano structure of boric acid-copper in an aqueous medium was produced using the chemical reduction method. The results indicated that soil type, boron source and number of spraying significantly affected (P ≤ 0.01) alfalfa boron concentration and pigment content. The mean of alfalfa boron concentration by B1 and B2 was 103.52 and 111.52% higher than control. The three-time spraying significantly increased B concentration related to the other spraying treatments (P ≤ 0.05) as it resulted in a 207.81% increase compared with the control treatment. The three-time spraying resulted in the highest increase of pigment contents (P ≤ 0.05) including chlorophyll a, b, total, and carotenoids compared with the other treatments. Although the highest boron and pigment contents were resulted by the three-time spraying, the combined use of B2 and the two-time spraying was the most optimum treatment (non-toxic) significantly increasing alfalfa boron and pigment contents (P ≤ 0.05). It would be possible to produce alfalfa at large amounts and with suitable forage quality using boron nano fertilization (synthesized and tested in this research work) under calcareous conditions.Graphical abstractGraphical abstract for this articleThe TEM pictures of synthesized nano Cu and nano Cu-boric acid (Cu-B).
       
  • Assessing the dietary intake of calcium, magnesium, iron, zinc and copper
           in institutionalised children and adolescents from Guatemala. Contribution
           of nutritional supplements
    • Abstract: Publication date: May 2019Source: Journal of Trace Elements in Medicine and Biology, Volume 53Author(s): José Joaquín Muros, Carmen Cabrera-Vique, Mercedes Briones, Isabel Seiquer In childhood and adolescence an adequate mineral intake is essential for normal growth and immune function, and to prevent chronic diseases in adulthood. The aim of this study was to analyse the dietary intake of Ca, Mg, Fe, Zn and Cu in children and adolescents from an orphanage-school in Guatemala and to assess the mineral contribution of nutritional supplements used by this population. Mineral content was analysed in nutritional supplements, bioaccesible fractions obtained after an in vitro gastrointestinal method, and diets sampled by a 7-day duplicate diet study. The average mineral content in the duplicate diets, including supplements, was (mg/d): Ca 452, Mg 230, Fe 25, Zn 8 and Cu 0.22. Especially Ca and Cu values were below recommended daily intakes. The content of these minerals in the nutritional supplements (mg/serving) was 49–112 for Ca, 1.2–3.8 for Fe, 24–47 for Mg, 0.7–4.16 for Zn and 0.08-0.23 for Cu. A great proportion of dietary minerals was provided by supplements, the contribution of which was: Ca 53.1%, Mg 58.4%, Fe 27.6%. Zn 82.2% and Cu 98.5%. Mineral bioaccessibility in supplements was particularly low for Ca and, to a lesser extent, for Fe and Zn. In spite of the high supplement consumption (up to 4 servings/d) important mineral deficiencies were detected in the diet of institutionalised children. Findings suggest that formulation and nutritional values of supplements used in Latin America should be carefully reviewed, in order to be a useful tool in the prevention and treatment of hidden hunger.Graphical abstractGraphical abstract for this article
       
  • In vitro gastrointestinal digestion to evaluate the total, bioaccessible
           and bioavailable concentrations of iron and manganese in açaí (Euterpe
           oleracea Mart.) pulps
    • Abstract: Publication date: May 2019Source: Journal of Trace Elements in Medicine and Biology, Volume 53Author(s): Silvana Ruella Oliveira, Katherine Chacón-Madrid, Marco Aurélio Zezzi Arruda, Fernando Barbosa Júnior Açaí pulp consumption has increased in Brazil and worldwide. Recently, a high average content of manganese (450 mg/kg) was observed in açaí pulp, raising the hypothesis of toxicological effects associated to its ingestion. However, the total concentration of an element does not reflect the real benefits and risks of consuming a food. In this context, the total, bioaccessible and bioavailable concentrations of Fe and Mn were assessed in 9 açaí pulps. Fe and Mn contents ranged from 27.6 to 73 and from 145 to 1197 mg kg−1, respectively. Fe and Mn bioaccessibilities represented from 29 to 40 and from 39 to 55% of total amounts. Fe bioavailabilities were lower than LOQ and those of Mn varied from 8 to 17% of total. A daily consumption of 100 g of açaí pulp exceeds by at least 1.5-fold the recommended Mn daily intakes for adults whereas poorly contributes to Fe intakes. Since the lowest Mn bioaccessible and bioavailable fraction corresponded to a Mn intake value higher than the tolerable upper intakes for children and that high amounts of Mn intake may impair Fe absorption, higher açaí consumption may be worrisome. Future nutritional, toxicological and speciation studies must be undertaken.Graphical abstractGraphical abstract for this article
       
  • High iodine intake and central lymph node metastasis risk of papillary
           thyroid cancer
    • Abstract: Publication date: May 2019Source: Journal of Trace Elements in Medicine and Biology, Volume 53Author(s): Hengqiang Zhao, Hehe Li, Tao Huang The relationship between iodine intake and clinicopathologic characteristics of papillary thyroid cancer (PTC) is unclear. We aim to investigate the relationship between iodine intake and central lymph node metastasis (CLNM) of PTC. A total of 4040 consecutive patients with PTC receiving thyroidectomy and central lymph node dissection were enrolled from 2013 to 2018. Pathological features of tumors and urinary iodine concentration (UIC) were recorded. Multivariate analysis was performed to investigate the association between iodine intake and CLNM of PTC. More than adequate (UIC: 200.0-299.9 μg/L) and excessive iodine intake (UIC ≥ 300.0 μg/L) were present in 1741 cases (43.09%). Iodine deficiency (UIC ≤ 99.9 μg/L) was inversely associated with female PTC risk only with OR (95% CI): 0.48 (0.29–0.80) relative to adequate iodine intake (UIC: 100.0–199.9 μg/L). However, more than adequate and excessive iodine intake was not associated with PTC risk among the general population and patients with thyroid nodules. In addition, high iodine intake was not associated CLNM risk of PTC. After defining CLNM as metastatic lymph nodes ≥ 2, excessive iodine intake was marginally associated with CLNM among female PTC patients with OR (95% CI): 1.25 (0.99–1.57) by multivariate analysis. Additionally, excessive iodine intake was marginally associated with larger tumor size and capsular invasion. Furthermore, we found that female PTC patients were more closely linked with iodine intake than male ones. In conclusion, high iodine intake appears not to be an initiator, but may be a weak promoter for female PTC progression, which needs further validation.
       
  • The analysis of Cu, Mn and Zn content in prescription food for special
           medical purposes and modified milk products for newborns and infants
           available in Polish pharmacies from toxicological and nutritional point of
           view
    • Abstract: Publication date: May 2019Source: Journal of Trace Elements in Medicine and Biology, Volume 53Author(s): Kamil Jurowski, Mirosław Krośniak, Maria Fołta, Barbara Tatar, Michael Cole, Wojciech Piekoszewski BackgroundPrescription food for special medical purposes (FSMPs) and modified milk products (MMPs), available in pharmacies, are important for newborns and infants that are not breastfed. In the scientific literature there is a lack of comprehensive studies and corresponding safety assessment of the essential trace elements in these products.ObjectiveThe aim of this article was determination of Cu, Mn and Zn levels in the most frequently available prescription FSMPs (n = 6) and MMPs (n = 6) available in Polish pharmacies.MethodsFlame absorption spectrometry (FAAS) following microwave induced digestion (concentrated nitric acid) was applied to determine the levels of the elements in the products.ResultsOur studies are based on a triple approach (1) the “raw results” of Cu, Mn and Zn levels (products in powdered form), (2) single intake - the level of each essential trace element consumed in one portion, (3) the daily intake depending on age and weight including comparison with Adequate Intake established by European Food Safety Authority.ConclusionThe results show the occurrence of differences between the manufacturer’s declared composition and the finished product for consumption. The prescription FSMPs in comparison to MMPs available in Polish pharmacies contain similar levels of Cu, Mn and Zn. Our results show additionally that all of the products do not represent a health hazard to the newborns and infants. This is a pioneer study in terms of the safety assessment, and quality of prescription FSMPs and MMPs available in Polish pharmacies from toxicological and nutritional point of view.Graphical abstractGraphical abstract for this article
       
  • Absorption of strontium by foods prepared in drinking water
    • Abstract: Publication date: May 2019Source: Journal of Trace Elements in Medicine and Biology, Volume 53Author(s): Lisa Jo Melnyk, Maura J. Donohue, Maily Pham, Joyce Donohue Strontium (Sr) is a natural element, ubiquitous in the environment and known to occur in water, food, air, and soils. Strontium is present in media as a salt or an ionized divalent cation. The Sr ion (dissociated) is toxicokinetically important because it is easily absorbed into systemic circulation when inhaled with particulates or ingested with water or foods. Dietary exposure can be influenced by using tap water containing dissolved Sr in food preparation. Research was conducted to determine the amount of Sr transferred from water to individual foods during preparation. Strontium transferred to broccoli, lentils, and spaghetti at all levels tested (1.5, 10, and 50 mg/L) as evidenced by the residual Sr in the pour-off water following food preparation (33–64%). The data from the cooking study support the hypothesis that cooking of foods with water containing Sr adds to total dietary exposure. This information can inform the determination of the relative source contribution (RSC) that is typically used in developing drinking water advisory guidelines. These cooking study results indicate that food prepared in water containing Sr should be considered as part of the food in a dietary exposure assessment.
       
  • Selenium and selenium species in the etiology of Alzheimer’s dementia:
           The potential for bias of the case-control study design
    • Abstract: Publication date: May 2019Source: Journal of Trace Elements in Medicine and Biology, Volume 53Author(s): Marco Vinceti, Bernhard Michalke, Carlotta Malagoli, Marcel Eichmüller, Tommaso Filippini, Manuela Tondelli, Annalisa Bargellini, Giulia Vinceti, Giovanna Zamboni, Annalisa Chiari Several human studies imply that the trace element selenium and its species may influence the onset of neurological disease, including Alzheimer’s dementia (AD). Nevertheless, the literature is conflicting, with reported associations between exposure and risk in opposite direction, possibly due to biases in exposure assessment.After conducting a cohort study that detected an excess AD risk associated with higher levels of inorganic-hexavalent selenium in subjects with mild cognitive impairment (MCI), we investigated the relation between selenium and AD using a case-control study design. We determined cerebrospinal fluid levels of selenium species in 56 MCI participants already included in the cohort study, considered as referents, and in 33 patients with established AD.AD risk was inversely correlated with inorganic selenium species and with the organic form bound to selenoprotein P. Selenium bound to other organo-selenium species was positively correlated with AD risk, suggesting compensatory selenoprotein upregulation following increased oxidative stress. The finding of an increased AD risk associated with inorganic-hexavalent selenium from the cohort study was not replicated.This case-control study yielded entirely different results than those generated by a cohort study with a partially overlapping participant population, suggesting that case-control design does not allow to reliably assess the role of selenium exposure in AD etiology. This inability appears to be due to exposure misclassification, falsely indicating an etiologic role of selenium deficiency likely due to reverse causation, and involving most selenium species. The case-control design may instead lend insights into the pathologic process underlying disease progression.
       
  • Environmental boron exposure does not induce DNA damage in lymphocytes and
           buccal cells of females: DNA damage in lymphocytes and buccal cells of
           boron exposed females
    • Abstract: Publication date: May 2019Source: Journal of Trace Elements in Medicine and Biology, Volume 53Author(s): Nurşen Başaran, Yalçın Duydu, Aylin Üstündağ, Gökçe Taner, Sevtap Aydin Dilsiz, Hatice Gül Anlar, Can Özgür Yalçin, Merve Bacanli, Klaus Golka, Tanja Schwerdtle, Hermann M. Bolt Boron (B) compounds are essential for plants and animals and beneficial for humans in nutritional amounts. I animals and humans increasing evidence have shown beneficial effects on B compounds on nutrition and on antioxidant status. The genotoxic effects of environmental B exposure in women living in boron-rich and boron-poor areas was examined in this study. For this purpose, the DNA damage in the lymphocytes and buccal cells of females were assessed by Comet and micronucleus (MN) assays respectively. No significant difference was observed in the DNA damage of the lymphocytes of B exposed groups of female volunteers in Comet assay. Even buccal micronucleus (MN) frequency observed in the high exposure group was significantly lower than the low exposure group (p 
       
  • Levels of serum trace elements in patients with primary open-angle
           glaucoma
    • Abstract: Publication date: May 2019Source: Journal of Trace Elements in Medicine and Biology, Volume 53Author(s): Alexander Fick, Anselm Jünemann, Bernhard Michalke, Marianna Lucio, Bettina Hohberger PurposeGlaucoma disease is known as multifactorial. Trace elements seemed to be linked via oxidative stress mediated changes to the complex glaucoma pathophysiology. Thus, it was the aim of this study to investigate serum levels of trace elements in primary open-angle glaucoma patients (POAG).Patients and methodsPeripheral venous blood samples were taken from a total of 40 subjects: 22 primary open-angle glaucoma patients (mean age 58.1 ± 13.9, female 8, male 14) and 18 controls (mean age 38.9 ± 11.6, 6 female 6, male 12). Serum samples of cadmium, cobalt, copper, iron, lead, manganese and zinc were analyzed by Inductively-Coupled-Plasma-Optical Emission Spectrometry (Cu, Fe, Zn) and Inductively-Coupled-Plasma-sectorfield-Mass-Spectrometry (Cd, Co, Mn, Pb, Se). Data were analyzed using ANCOVA and presented as log transformed LS-mean.ResultsPatients with POAG had significantly increased serum levels of iron (2.98 ± 0.03 μg/L vs 2.98 ± 0.03 μg/L) when compared to controls, and of cadmium (1.57 ± 0.05 ng/L vs. 1.40 ± 0.06 ng/L) considering the interaction between age and the class variable (control versus POAG). A gender effect was seen for cadmium, cobalt, copper, and iron in controls and POAG patients. Iron concentration was reduced in dependency of age for both genders in normals, however lesser in POAG patients. No difference was seen in serum levels of lead, manganese, and zinc between patients with POAG and controls.ConclusionA significant elevation of serum cadmium and iron levels in POAG patients as well as an additional gender effect of cadmium, cobalt, copper, and iron in normals and POAG patients, may argue for a potential role of these trace elements in the pathogenesis of primary open-angle glaucoma.
       
  • Assessment of 7 trace elements in serum of patients with nontuberculous
           mycobacterial lung disease
    • Abstract: Publication date: May 2019Source: Journal of Trace Elements in Medicine and Biology, Volume 53Author(s): Jongwon Oh, Sun Hye Shin, Rihwa Choi, Serim Kim, Hyung-Doo Park, Su-Young Kim, Sun Ae Han, Won-Jung Koh, Soo-Youn Lee Nontuberculous mycobacterial (NTM) lung diseases are an emerging cause of pulmonary infection, becoming more common in the clinical setting as incidence of NTM lung diseases steadily increases worldwide. Trace elements are essential micronutrients and are known to play many important roles in infectious diseases. We investigated the concentrations of trace elements in patients with NTM lung disease and compared these values to patients with pulmonary tuberculosis and healthy controls. A case-control study was conducted to evaluate the serum trace element concentrations in 95 patients with NTM lung disease, 97 patients with pulmonary tuberculosis, and 99 healthy control subjects. The serum concentrations of 7 trace elements (cobalt, copper, chromium, manganese, molybdenum, selenium, and zinc) were measured using inductively coupled plasma-mass spectrometry. We also analyzed demographic data, clinical outcomes, and other biochemical parameters. The median serum concentrations of copper and molybdenum were higher in patients with NTM lung disease (109 vs. 91 μg/dL, p 
       
  • Measurement of the enriched stable isotope 58Fe in iron related disorders-
           comparison of INAA and MC-ICP-MS
    • Abstract: Publication date: May 2019Source: Journal of Trace Elements in Medicine and Biology, Volume 53Author(s): Tayser Yagob, Albert van de Wiel, Peter Bode, Ayse Demir, Bas van der Wagt, Petra Krystek, Bert Wolterbeek As a safer alternative for the use of radioactive tracers, the enriched stable 58Fe isotope has been introduced in studies of iron metabolism. In this study this isotope is measured with instrumental neutron activation analysis (INAA) in blood samples of patients with iron related disorders and controls after oral ingestion of a 58Fe containing pharmaceutical. Results were compared with those derived from MC-ICP-MS, applied on the same samples, and analytical and practical aspects of the two techniques were compared.Both techniques showed an increased absorption and incorporation in red blood cells of the 58Fe isotope in iron deficient patients in contrast to the controls. In all individuals results of INAA measurements were in good agreement with those of MC-ICP-MS ( zeta < 2). Uncertainties in INAA are substantially higher than those achievable by MC-ICP-MS but the INAA technique offers a high specificity and selectivity for iron close to 100%. In contrast to INAA, sample preparation before measurement is very critical in MC-ICP-MS and interferences with 58Ni and 54Cr may hamper the measurement of 58Fe and 54Fe respectively. Since it takes at least five days after irradiation to reduce the activity of interfering radionuclides (mainly 24Na), INAA is a more time consuming procedure; the need of a nuclear reactor facility makes it also less accessible than MC-ICP-MS. Costs are comparable.Both INAA and MC-ICP-MS are able to adequately measure changes in iron isotope composition in blood when an enriched stable iron isotope is applied in clinical research. Although MC-ICP-MS is more sensitive, is faster and has easier access, in INAA preparative steps before measurement are simpler and there are hardly demands on the kind and size of the samples. This may be relevant working with biomaterials in a clinical setting.Graphical abstractGraphical abstract for this article
       
  • Urinary ionomic analysis reveals new relationship between minerals and
           longevity in a Han Chinese population
    • Abstract: Publication date: May 2019Source: Journal of Trace Elements in Medicine and Biology, Volume 53Author(s): Qingxiu Li, Caiyou Hu, Jie Lin, Ze Yang, Qi Zhou, Ruiyue Yang, Huiping Yuan, Xiaoquan Zhu, Yuan Lv, Qinghua Liang, Zeping Lv, Liang Sun, Yan Zhang Human longevity involves genetic, nutritional, environmental and many other factors playing a key role in healthy aging. Previous studies have shown that mineral metabolism and homeostasis are associated with lifespan extension. However, the majority of them have focused on a limited number of elements and ignored the complex relationship between them. In this study, we carried out a network-based approach to investigate the urinary ionome of nonagenarians and centenarians (longevity group) when compared with their biologically unrelated and younger family members (control group) from a Han Chinese population. Several differentially changed elements were identified, almost all of which showed an elevated level in the longevity group. Correlation analysis of the ionome revealed significant element-element interactions in each group. We then divided each group into distinct subgroups according to age ranges, and built the elemental correlation network for each of them. Significant elemental correlations and correlation changes involving all examined elements were identified within or between different subgroups, implying a highly dynamic and complex crosstalk among the elements during human life. Finally, more similar elemental patterns were observed between extremely old and middle-aged people. Overall, our data reveal new relationship between urinary minerals and human longevity, which may extend our understanding of the mechanism of healthy aging.Graphical abstractGraphical abstract for this article
       
  • Monitoring of salt iodisation programme in Iran; Health outcomes,
           shortages and perspective
    • Abstract: Publication date: May 2019Source: Journal of Trace Elements in Medicine and Biology, Volume 53Author(s): Zheng Feei Ma, Yutong Zhang, Hang Zhou, Binyu Pan
       
  • Blood metals, age related macular degeneration and contrast sensitivity
           impairment
    • Abstract: Publication date: May 2019Source: Journal of Trace Elements in Medicine and Biology, Volume 53Author(s): Tomoyuki Kawada
       
  • Blood titanium level as a biomarker of orthopaedic implant wear
    • Abstract: Publication date: May 2019Source: Journal of Trace Elements in Medicine and Biology, Volume 53Author(s): Ilona Swiatkowska, Nicholas Martin, Alister J. Hart BackgroundJoint replacement implants are usually manufactured from cobalt-chromium or titanium alloys. After the device is implanted, wear and corrosion generate metal particles and ions, which are released into local tissue and blood. The metal debris can cause a range of adverse local and systemic effects in patients.Research problemIn the case of cobalt and chromium, a blood level exceeding 7 μg L−1 indicates potential for local toxicity, and a failing implant. It has been repeatedly suggested in the literature that measurement of titanium could also be used to assess implant function. Despite an increasing interest in this biomarker, and growing use of titanium in orthopaedics, it is unclear what blood concentrations should raise concerns. This is partly due to the technical challenges involved in the measurement of titanium in biological samples.AimThis Review summarises blood/serum titanium levels associated with well-functioning and malfunctioning prostheses, so that the prospects of using titanium measurements to gain insights into implant performance can be evaluated.ConclusionDue to inter-laboratory analytical differences, reliable conclusions regarding “normal” and “abnormal” titanium levels in patients with orthopaedic implants are difficult to draw. Diagnosis of symptomatic patients should be based on radiographic evidence combined with blood/serum metal levels.
       
  • The association of serum zinc and copper with hypertension: A
           meta-analysis
    • Abstract: Publication date: May 2019Source: Journal of Trace Elements in Medicine and Biology, Volume 53Author(s): Zhaoying Li, Weijing Wang, Hui Liu, Suyun Li, Dongfeng Zhang ObjectiveThe association of serum zinc (Zn), copper (Cu) with the risk of hypertension (HT) remains controversial. Therefore, we conducted a meta-analysis to explore the relationships.MethodsWe searched relevant literatures on PubMed and Web of Science up to September 2018. Pooled standard mean difference (SMD) with corresponding 95% confidence interval (CI) was calculated by random effects model.I2 was used to evaluate heterogeneity among studies.Results25 articles of serum Zn and 22 articles of serum Cu were included in meta-analysis. HT patients had lower serum Zn [SMD (95%CI): -0.612(-0.951, -0.274), z = 3.54, Pfor z
       
  • Placental levels of metals and associated factors in urban and sub-urban
           areas of Seville (Spain)
    • Abstract: Publication date: Available online 12 March 2019Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): L. Cerrillos, R. Fernández, M.J. Machado, I. Morillas, B. Dahiri, D. Gonzalez-Weller, A. Gutiérrez, C. Rubio, A. Hardisson, I. Moreno, A. Fernández-Palacín Environmental exposure to metals among women, revealed their adverse effects on pregnancy. The fetus is exposed to these toxic elements only via the placenta which are able to accumulate there or cross it, compromising the protective functions of this organ. Numerous studies have shown associations between the prenatal exposition to some metals and an impact on cognitive, motor and intellectual development of the child. Sixty two placental samples were taken at delivery to determine the mineral content (Al, B, Ba, Ca, Cd, Cr, Cu, Fe, K, Li, Mg, Mn, Mo, Na, Ni, Pb, Sr, V, Zn) by ICP-OES. Among these metals, essential ones (B, Ca, Cu, Fe, Mg, Mn, Mo, Na, Zn) can have health beneficial effects at low levels however, in high concentration are potentially toxic. On the other hand, elements such as Al, Cd, Pb, are classified as toxic metals, no matter what its concentration is. The aim of this study is to find the potential relationships between these metals levels, newborn's parameters, pregnancy details and the epidemiologic information obtained using a questionnaire data from the participant pregnant women from Seville (Spain).The main maternal determinant of detectable placenta Cd levels was smoking during pregnancy. Other maternal factors that may affect placenta metal levels were gestational age (Al, B, Ba, and Pb) or dietary supplement (Fe). It has to be stressed that our results have to be interpreted with caution, because of the small study group and the low exposure levels, along with the lack of information on potential sources of exposure to these metals. The use of placenta samples obtained at delivery can be considered strength of this study since the concentration of some metals in placenta can indicate the extent of maternal exposure during gestation.
       
  • 7-chloro-4-(phenylselanyl) quinoline prevents dopamine depletion in a
           Drosophila melanogaster model of Parkinson’s-like disease
    • Abstract: Publication date: Available online 15 October 2018Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): Shanda de Freitas Couto, Stífani Machado Araujo, Vandreza Cardoso Bortolotto, Marcia Rósula Poetini, Franciane Cabral Pinheiro, Elize Aparecida Santos Musachio, Luana Barreto Meichtry, Manoela do Sacramento, Diego Alves, Diogo La Rosa Novo, Márcia Foster Mesko, Marina Prigol Neurodegeneration in Parkinson's disease appears to be caused by multiple factors, including oxidative damage and an increase in acetylcholinesterase expression that can culminate in loss of dopaminergic neurons. A selenium-containing quinoline derivative, 7-chloro-4-(phenylselanyl) quinoline (4-PSQ), shows important pharmacological actions mainly attributed to its antioxidant and anticholinesterase properties. Thus, this study investigated the neuroprotective effect of 4-PSQ in a model of Parkinson’s-like disease induced by rotenone (ROT) in Drosophila melanogaster and verified whether these effects are related to selenium levels. Adult flies were divided into: [1] control, [2] 4-PSQ (25 μM), [3] ROT (500 μM), and [4] 4-PSQ (25 μM) + ROT (500 μM) groups and exposed to a diet containing ROT and/or 4-PSQ for 7 days, according to their respective groups. Survival, behavioral, and ex vivo analyses were performed. Dopamine levels, reactive species levels (RS), lipid peroxidation (LPO), superoxide dismutase (SOD) and catalase (CAT) activity, and proteic thiol (PSH) and non-proteic thiol (NPSH) content in the head region were analyzed, while acetylcholinesterase (AChE) activity and selenium levels in the head and body regions were analyzed. 4-PSQ was able to reverse the ROT-induced deficits in flies, reestablish dopamine and selenium levels, reverse cholinergic deficits, improve motor function, and ameliorate mortality. Furthermore, 4-PSQ also reduced RS levels and LPO, and restored the activities of the antioxidant enzymes, SOD and CAT. Interestingly, a positive relationship between dopamine and selenium levels could be seen. Our results demonstrate the neuroprotective effect of 4-PSQ, and we suggest that the compound may act via different mechanisms, such as improving antioxidant defenses and consequently reducing oxidative damages, as well as having an anticholinesterase action, which together can prevent dopamine depletion, as these actions were correlated with the presence of selenium in the 4-PSQ molecule.Graphical abstractNeuroprotective effect of 4-PSQ through different mechanisms of action, by improving antioxidant defenses and consequently reducing oxidative damages, and by anticholinesterase action, factors that together can prevent dopamine depletion, actions correlated with the presence of selenium in the molecule of 4-PSQ.Source: author’s personal archive.Caption: Full arrows demonstrate the results obtained in this study. Dotted lines represent some hypotheses of possible pathways in the mechanism of action, however they were not performed in this study.Graphical abstract for this article
       
  • Corrigendum to “The importance of boron in biological systems” [J.
           Trace Elem. Med. Biol. 45 (2018) 156–162]
    • Abstract: Publication date: Available online 27 April 2018Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): Irem Uluisik, Huseyin Caglar Karakaya, Ahmet Koc
       
  • Corrigendum to “Synthesis and characterization of new
           1-hydroxy-2-pyridinethione derivatives: Their lead complexes and efficacy
           in the treatment of acute lead poisoning in rats” [J. Trace Elem. Med.
           Biol. 44 (December 2017) 209–217]
    • Abstract: Publication date: Available online 13 February 2018Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): Manal H. Al Khabbas, Samah A. Ata, Kamal I. Abu-Dari, Maha F. Tutunji, Mohammad S. Mubarak
       
 
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