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LABORATORY AND EXPERIMENTAL MEDICINE (99 journals)

Showing 1 - 99 of 99 Journals sorted alphabetically
AAPS PharmSciTech     Hybrid Journal   (Followers: 9)
Actualites Pharmaceutiques     Full-text available via subscription   (Followers: 7)
Adipocyte     Open Access   (Followers: 1)
African Journal of Laboratory Medicine     Open Access   (Followers: 2)
American Journal of Experimental and Clinical Research     Open Access   (Followers: 4)
American Journal of Medical and Biological Research     Open Access   (Followers: 10)
Animal Models and Experimental Medicine     Open Access  
Annals of Clinical Chemistry and Laboratory Medicine     Open Access   (Followers: 5)
Applied In Vitro Toxicology     Hybrid Journal   (Followers: 2)
Archives of Clinical and Experimental Medicine     Open Access  
Archives of Medical Research     Hybrid Journal   (Followers: 3)
Archives of Pathology & Laboratory Medicine     Full-text available via subscription   (Followers: 31)
Archives of Preventive Medicine     Open Access   (Followers: 3)
Biomedical Engineering     Hybrid Journal   (Followers: 3)
Bulletin of Experimental Biology and Medicine     Hybrid Journal  
Clinica Chimica Acta     Hybrid Journal   (Followers: 30)
Clinical & Experimental Metastasis     Hybrid Journal  
Clinical and Experimental Medical Journal     Full-text available via subscription   (Followers: 1)
Clinical and Experimental Medicine     Hybrid Journal   (Followers: 4)
Clinical Trials     Hybrid Journal   (Followers: 21)
Clinical Trials in Degenerative Diseases     Open Access  
Clinical Trials in Orthopedic Disorders     Open Access   (Followers: 1)
Current Medicine Research and Practice     Full-text available via subscription  
Current Research in Drug Discovery     Open Access   (Followers: 1)
Drug Design, Development and Therapy     Open Access   (Followers: 4)
Ecography     Hybrid Journal   (Followers: 28)
European Journal of Hospital Pharmacy : Science and Practice (EJHP)     Hybrid Journal   (Followers: 8)
European Journal of Medical Research     Open Access   (Followers: 1)
European Journal of Nanomedicine     Hybrid Journal   (Followers: 1)
Experimental & Molecular Medicine     Open Access   (Followers: 1)
Experimental Aging Research: An International Journal Devoted to the Scientific Study of the Aging Process     Hybrid Journal   (Followers: 3)
Experimental and Therapeutic Medicine     Full-text available via subscription   (Followers: 1)
Experimental Biology and Medicine     Hybrid Journal   (Followers: 3)
Expert Opinion on Drug Delivery     Hybrid Journal   (Followers: 20)
Frontiers in Laboratory Medicine     Open Access  
Frontiers in Medical Technology     Open Access   (Followers: 1)
IN VIVO     Full-text available via subscription   (Followers: 5)
International Archives of Biomedical and Clinical Research     Open Access  
International Journal of Experimental Pathology     Hybrid Journal   (Followers: 1)
International Journal of Health Research and Innovation     Open Access   (Followers: 1)
International Journal of Research in Medical Sciences     Open Access   (Followers: 5)
International Journal of Statistics in Medical Research     Hybrid Journal   (Followers: 5)
Journal of Cell Science & Therapy     Open Access   (Followers: 1)
Journal of Applied Biomaterials & Functional Materials     Hybrid Journal   (Followers: 1)
Journal of Biomedical and Clinical Research     Open Access  
Journal of Clinical Laboratory Analysis     Open Access   (Followers: 14)
Journal of Clinical Medicine and Research     Open Access  
Journal of Clinical Medicine Research     Open Access   (Followers: 4)
Journal of Clinical Trials     Open Access   (Followers: 6)
Journal of Current and Advance Medical Research     Open Access   (Followers: 1)
Journal of Current Medical Research and Practice     Open Access  
Journal of Current Research in Scientific Medicine     Open Access  
Journal of Current Researches on Health Sector     Open Access  
Journal of Drug Delivery and Therapeutics JDDT     Open Access   (Followers: 1)
Journal of Enzyme Inhibition and Medicinal Chemistry     Open Access   (Followers: 4)
Journal of Experimental & Clinical Medicine     Full-text available via subscription   (Followers: 1)
Journal of Experimental & Clinical Cancer Research     Open Access   (Followers: 2)
Journal of Experimental and Clinical Medicine     Open Access  
Journal of Experimental Medicine     Full-text available via subscription   (Followers: 45)
Journal of Experimental Pharmacology     Open Access   (Followers: 2)
Journal of Histotechnology     Hybrid Journal   (Followers: 2)
Journal of International Medical Research     Open Access   (Followers: 3)
Journal of Investigative Medicine High Impact Case Reports     Open Access  
Journal of Medicine and Biomedical Research     Open Access   (Followers: 1)
Journal of Muhammadiyah Medical Laboratory Technologist     Open Access  
Journal of Operating Department Practitioners     Full-text available via subscription   (Followers: 2)
Journal of the American Society of Cytopathology     Hybrid Journal   (Followers: 6)
Journal of Trace Elements in Medicine and Biology     Hybrid Journal   (Followers: 1)
Lab on a Chip     Full-text available via subscription   (Followers: 42)
Laboratory Investigation     Hybrid Journal   (Followers: 3)
Medical Devices & Sensors     Hybrid Journal  
Medical Image Analysis     Hybrid Journal   (Followers: 15)
Medical Instrumentation     Open Access  
Medical Laboratory Observer     Full-text available via subscription  
Medical Laboratory Technology Journal     Open Access  
Medicinal Chemistry Research     Hybrid Journal   (Followers: 12)
Medtech Insight     Full-text available via subscription   (Followers: 4)
Nanomedicine: Nanotechnology, Biology and Medicine     Hybrid Journal   (Followers: 7)
New Zealand Journal of Medical Laboratory Science     Full-text available via subscription   (Followers: 1)
Oriental Pharmacy and Experimental Medicine     Partially Free   (Followers: 3)
Pathology and Laboratory Medicine International     Open Access   (Followers: 7)
Physical Biology     Hybrid Journal   (Followers: 4)
Practical Laboratory Medicine     Open Access   (Followers: 2)
Proceedings of the Institution of Mechanical Engineers Part H: Journal of Engineering in Medicine     Hybrid Journal   (Followers: 3)
Prosthetics and Orthotics International     Hybrid Journal   (Followers: 9)
Pulse     Full-text available via subscription  
Qualitative Research in Medicine & Healthcare     Open Access  
Recent Advances in Biology and Medicine     Open Access  
Regulatory Toxicology and Pharmacology     Hybrid Journal   (Followers: 43)
Reproduction     Full-text available via subscription   (Followers: 7)
Revista Peruana de Medicina Experimental y Salud P├║blica     Open Access  
Revista Romana de Medicina de Laborator     Open Access  
RSC Medicinal Chemistry     Full-text available via subscription   (Followers: 6)
SA Pharmacist's Assistant     Open Access  
Savannah Journal of Medical Research and Practice     Full-text available via subscription  
SLAS Technology     Hybrid Journal   (Followers: 2)
Statistics in Medicine     Hybrid Journal   (Followers: 190)
Trends in Molecular Medicine     Full-text available via subscription   (Followers: 14)
Turkish Journal of Clinics and Laboratory     Open Access   (Followers: 1)
Similar Journals
Journal Cover
Turkish Journal of Clinics and Laboratory
Number of Followers: 1  

  This is an Open Access Journal Open Access journal
ISSN (Online) 2149-8296
Published by DNT Ortadogu Yayincilik AS Homepage  [1 journal]
  • Advanced oxidation protein products and monocyte chemoattractant protein-1
           in periodontal disease

    • Authors: Meltem Hendek; Ebru Olgun Erdemir, Üçler Kısa
      Abstract: Aim:The aim of the study was to determine gingival crevicular fluid (GCF) levels ofadvancedoxidation protein product (AOPP) and monocyte chemoattractant protein (MCP)-1in subjects with periodontal disease and health. Material and Method:A total of 75 non-smokers, including 25 participantswith chronic periodontitis (CP), 25 participantswith gingivitis (G) and 25 participants with periodontallyhealthy (H) were included into the present study.The probing depth (PD), clinical attachment level (CAL), plaque index(PI) and gingival index (GI) were recorded. The GCF samples from4 sites in each individual werecollected and GCF AOPP and MCP-1 levels were determinedby enzyme-linked immunosorbent assay method.Results:GCFAOPP and MCP-1 levels were the lowestin the H group; followed by the G group and the highest in the CP group. Thesedifferences were statistically significant between G and H groupsand between the CP and the other groups (p <.05). A statistically positive correlation was detectedbetween GCF AOPP and MCP-1 levels. Conclusion: GCFAOPP andMCP-1 levels mightplay a considerable role during periodontal inflammation and an elevated GCF AOPP and MCP-1levels are suggested as a potential biomarker forperiodontal diseases.
      PubDate: Sat, 01 Dec 2018 00:00:00 +030
       
  • Mean platelet volume in type 2 diabetic patient: is there a relationship
           between mean platelet volume and diabetic microvascular complications'
           

    • Authors: Kenan Çadırcı; Osman Okan Olcaysu, Derman Yiğit, Ayşe Çarlıoğlu, Şenay Arıkan
      Abstract: Aim: Most diabetic patients suffer from vascular thromboticand atherosclerotic  complications.Alteration in platelet size are associated with atherosclerotic complicationsin patients with diabetes. The aim of present study is to determine therelationship between mean platelet volume (MPV) and microvascular diabeticcomplications in type 2 diabetic patients.Material andMethod: 115 type 2 diabeticpatients [mean age 50.4±9.9 year and body mass index (BMI) 31.0±5.3 kg/m2],and 67 healthy control subjects without any systemic disease (mean age48.8±12.0 year and BMI 30.3±7.3 kg/m2) were included in this study.Chronic diyabetic microvascular complications in diyabetic group wereresearched. Neurological evaluation, ocular fundus examination and EMG (electromyography)were performed. Our diabetic patients were initially divided into two groupswith and without at least one microvascular complication. Subsequently,patients with microvascular complications were divided into subgroups accordingto nephropathy, neuropathy and retinopathy. MPV levels were re-analyzed in allsubgroups.Results: There were 79 patients in our diabetic patient groupwith at least one microvascular complication. In this group, 44 (34.7%) patient neuropathy, 33(26.0%) patients diabetic nephropathy and 13 (10.2%) patients diabeticretinopathy were detected. There were 36 patients in the diabetic group withoutmicrovascular complications. This group was accepted as a diabetic controlgroup.We determinedthat mean MPV levels in diabetic microvascular group was significantlydifferent from control group (8.6±0.8 fL and 7.9±0.8 fL, p<0.001). Again wedetermined that mean MPV levels in diabetic control group was significantlydifferent from control group (8.3±0.5fL ve 7.9±0.8fL, p=0.005) Despite the difference in MPV between the diabetic microvasculargroup and the diabetic control group, this difference was not statisticallysignificant ( 8.6±0.8 fL, 8.3±0.5 fL, p=  0.06).In subgroupanalysis, we demonstrated that mean MPV levels in diabetic nephropathy (p=0.006) and in diabetic neuropathy groups (p=0.001) and diabeticretinopathy group (p=0.02) werehigher than control subjects.  Conclusions: In our study, we determined mean MPV levels in type 2 diabetic group wassignificantly highly from control group. Also, we detected MPV level in diabetic patients withnephropathy, neuropathy and retinopathy is more increase than healthy subjects.Although MPV is often used as the marker of platelet activity, elevated MPVlevels in patients with type 2 diabetes mellitus may associate with increased microvascularcomplication risk. 
      PubDate: Sat, 01 Sep 2018 00:00:00 +030
       
  • Acute effect of moderate exercise on oxidative stres in smoker versus
           non-smokers

    • Authors: Banu Çaycı; Berrin Gunaydin, Seher Yuksel, Sibel Soylemez, Çağrı Altundarak
      Abstract: Aim: One of the particularsources of oxidative stress is smoking and thiobarbituric acid reactivesubstances (TBARS) and malondialdehyde (MDA) have been used as biomarkers of lipidperoxidation of oxidative damage. Therefore, we aimed to investigate the acuteeffect of moderate exercise on oxidative stress by determining serum MDA levelsby TBARS in moderate smoker subjects versus non-smokers. Material & Methods: Fiftyhealthy subjects performing moderate intensity exercise were assigned to 2groups as moderate smokers (11-20 cigarettes/day) (Group Smoker, n=25) andnon-smokers (Group Non-Smoker, n=25). Venous blood samples were collected fromall participants half an hour before exercise (pre-exercise) and immediatelyafter exercise (post-exercise) to determine MDA levels as an indicator of lipidperoxidation in the serum by TBARS/UV (ultra violet).Results: Although no significantdifferences were observed in pre-exercise MDA levels between the groups,post-exercise MDA levels in smokers were significantly higher than that ofnon-smokers (p<0.05).Conclusion: The MDAdetermination in serum by TBARS/UV appears to be positively correlated withsmoking status in particularly female subjects. Therefore, it can be a promisinghelpful tool in demonstrating the oxidative stress due to moderate exerciseparticularly in smokers to reorganize a healthier life style.
      PubDate: Thu, 22 Mar 2018 00:00:00 +030
       
  • Comparison of Elastane Fiber with Polyprolene and Polyglecaprone 25 used
           as Surgical Suture Material: an experimental preliminary study

    • Authors: Mehmet Kabalcı; Nesimi Günal, Yasemin Dere Günal, Ali Bolat, Mahi Balcı, Berkant Özpolat, Koray Dural, Serap Yörübulut, Erdinç Eroğlu
      Abstract: Aim:  Elastane  fiber  is  a  synthetic  monofilament polymer  which  is  durable  and  highly  flexible. In  this  preliminary study  we  compared Elastane  fiber  with  polypropylene  and  polyglycaprone  25,  surching  the  inflammatory  reaction in  the  rat  soft  tissue, considering  that  it  could  be  used  for  sternal  closure because  of  its  properties.  Material  and  Methods: Elastane  fiber,  polypropylene  and  polyglycaprone25  sutures were  placed  in  3  separate areas  at  2  cm  intervals in  the  subcutaneous tissue  of  each  8  male  wistar  albino rats  without  any  incision,  using  the  seldinger method.  After  two  weeks,  the  rats  were  sacrified  and  tissue  specimens, including  the  suture fragments,  were  resected. Histopathological scoring  in  terms  of  inflammation, vascularization,  fibrosis  and  histiocytic  reaction were  achieved  semiquantitatively.  Results:  There  was  no  statistically  significant difference  between  three  suture  materials in  terms  of  inflammation  (p=0.513),  vascularization  (p=0.065),  fibrosis (p=0.108)  and  histiocytic  reaction (p=0.630).  Conclusion:  As  a  conclusion elastane  fiber  showed  similar inflammatory  changes  with  other  suture materials  in  the  rat  soft  tissue  which  is  thought to  be  useful for  sternal  closure due  to  its  high  flexibilityand  durability.  
      PubDate: Sat, 03 Mar 2018 00:00:00 +030
       
  • Relationship between nodular thyroid disease and metabolic paramethers in
           patients with acromegaly

    • Authors: Bekir Uçan; Mustafa Şahin, Muhammed Kızılgül, Mustafa Özbek, İlknur Ünsal, Erman Çakal
      Abstract: Aim: Thehigh prevalence of nodular goiter in patients with acromegaly is well known. Insulin-like growth factor-1 (IGF-1) has been claimed to be one of the etiologic factors. The aim of the study was toevaluate the incidence of thyroid lesions in ouracromegalic patients and to analyze possible factors influencing thyroid noduledevelopment, especially insulin resistance and hormonal parameters. Material and Methods: Sixty patients with acromegaly, 32 females, and 28 males,with a mean age of 52.7 ± 10.0 years withoutknown thyroid diseasewere included. Age and sex matched 100 control subjectsalso included in the study. Waist and hip circumference, weight,and height, fasting blood glucose, postprandial blood glucose,insulin, thyroid functiontests, thyroid autoantibodies,lipid profile, IGF-1, growth hormone, other anterior pituitaryhormone levels were measured in allpatients. Magnetic Resonance Imaging (MRI) andthyroid ultrasonography (US)was performed in allpatients. Thyroid nodulevolume and thyroid volume were calculated. Results: Thirty-five (58.3%)patients with acromegaly had thyroid nodules according to(% 25) in control group (p<0,0001). There were significant differences inBMI, thyroid volume, fasting glucose and TSH levels between patients andcontrols. After regressionanalysis, thyroid volume was associated with insulin, waist circumference, HOMA-IR, LDL-cholesteroland the size of the pituitary adenoma (p<0.05) or diabetes occurrence. During the logisticregression analysis, the presenceof nodules was strongly associated with luteinizinghormone (LH) (p<0.02) and HDL-cholesterol levels (p<0.05). Nodule volume weresignificantly associated with LH level (p<0.05), ACTH (beta= -0.51, p< 0.01),plasma cortisol (beta= 0.965, p <0.05), freeT4 (beta= 0.522, p<0.05), the size of adenoma (beta= 0.615,p<0.05) in the regression analysis.Conclusion: The prevalence of nodules in acromegalic patientswere found to be higher than usual prevalence. In addition to IGF-1, otherhormones and insulin resistance might play an important role in thyroid volume,nodule volume, and nodule formation mechanism in patients with acromegaly.
      PubDate: Thu, 01 Mar 2018 00:00:00 +030
       
  • An etiological searching for multiple displaced metatarsal stress
           fractures

    • Authors: Kadri Yıldız; Esra Demirel, Kenan Çadırcı, Eyüp Şenocak
      Abstract: Metatarsal fracture that is improved by using low-dosecortico-steroid for a long time due to secondary osteoporosis reason by rheumatoidarthritis. 53 year-old female patient use low-dosecortico-steroid for 12 years due to Rheumatoid Arthritis. At the last clinicaktrials, multiple metatarsal fractures occured before 3 months. Multilpe metatarsalfracture were fixed by conservative treatment on the serial clinicaltrials for 3 month. In patients which have used corticosteroid, even iflow-dose, fractıres can be seen on the unusual bones.
      PubDate: Thu, 01 Mar 2018 00:00:00 +030
       
  • Effects of carbon monoxide poisoning on temperament

    • Authors: Oğuz Eroğlu; Orhan Murat Koçak, Şadiye Visal Buturak, Figen Coşkun, Ayşe Gül Yılmaz Özpolat, Turgut Deniz
      Abstract: Aim:The aim of this study was toinvestigate the effect of carbon monoxide(CO) poisoning on temperament andassociated disorders.Materialand Methods: The study was conducted inhealthy volunteers and patientswho presented to the Emergency Department of Kirikkale University Hospital after exposure to CO. Patients with a carboxyhemoglobinlevel of ≥10% were consideredto have CO poisoning. Patients withpsychiatric disease or an illness that could increase CO levels andthose who smoked orwere using medication wereexcluded. Healthy volunteers were evaluated once, and CO poisoning patients wereevaluated at the time of presentationand 3 months after discharge using the Temperament Evaluation of Memphis, Pisa,Paris, and San DiegoAutoquestionnaire (TEMPS-A) temperament scale. Repeated analysis ofvariance was appliedfor comparisons. A pvalue of <0.05 was considered statistically significant.Results:The study included 110participants: 68 in the CO poisoning group and 42 healthy volunteers. Significantdifferences between the groups were observed in the TEMPS-Ascores for depressive type (p=0.016) and anxious type(p=0.01) at first presentation and forthe irritability type (p=0.02) and anxious type(p=0.034) at 3months after the discharge.When the temperament scale scores of the CO poisoning patients were compared accordingto evaluation time (first presentation and 3months after discharge), no significantdifference in temperament types was observed.Conclusion:Although the temperament typesrelated to depression and anxiety were affected after CO poisoning, theydid notchange completely.Further research isneeded to better understand thepsychiatric effects of CO poisoning.
      PubDate: Thu, 01 Mar 2018 00:00:00 +030
       
  • Bactericidal and antibiofilm activities of copper against biofilm producer
           pathogens colonized on orthopedic implants

    • Authors: Sahra Kırmusaoğlu
      Abstract: Background:New and alternative antimicrobial and antibiofilm agent discovery has gained attention since antibiotic resistancewas easily developed. It has been accepted that metals haveantimicrobial activity. Abiotic surfaces such as orthopedic implants that areimpregnated with copper can prevent colonization of biofilm producer pathogens,and can detach biofilms produced on implants. In this study, the effects ofcopper against planktonic bacteria and biofilm embedded bacteria adhered on kirschnerwire orthopedicimplant were studied. Materialand Methods: MICs, MBCs and MBEC of copper against main biofilm producer pathogenssuch as methicillin resistance Staphylococcus aureus (MRSA), methicillin sensitive Staphylococcus aureus (MSSA), methicillinresistance Staphylococcus epidermidis (MRSE), methicillin sensitive Staphylococcus epidermidis (MSSE),Escherichia coli (E. coli),Klebsiella pneumoniae (K. pneumoniae), Pseudomonas aeruginosa (P.aeruginosa), Proteus mirabilis (P. mirabilis) colonized on kirschner wire orthopedic implant were determined.Results:MICs,MBCs, and MBECs of copper against pathogens were ranged from 0.063 to 0.75mg/mL. This study revealed that 0.75mg/mL of copper inhibit all isolatesanalyzed in this study. The most tolerant pathogen was MRSA. The activities ofcopper against biofilm embeddedbacteria and planktonic bacteria were found to be the same.Conclusion:Indwellingmedical devices such as orthopedic wires, prosthetics can be impregnated bycopper to overcome colonization and production of matured biofilm on indwellingdevices, consequently, implant associated infections. 
      PubDate: Thu, 01 Mar 2018 00:00:00 +030
       
  • Pediatric urinary infections

    • Authors: Ayşegül Alpcan; Serkan Tursun, Banu Çelikel Acar
      Abstract: Urinarytract infections are very common in children. The most common pathogensisolated in urinary tract infections are Escherichia coli.  Theincidence of Urinary tract infections  in children 4-8 %in girls and 1-2 % in boys. Urinary tract infections in children is of concern because it can be associatedwith  urosepsis, renal scarring,hypertension, and chronic renal insufficiency. In this reviewwe aim to describe the diagnosis and management of acute and recurrent urinarytract infections in the pediatric population.
      PubDate: Fri, 01 Dec 2017 00:00:00 +030
       
  • A case of foreign body aspiration diagnosed 5 years after the incident

    • Authors: Serhat Yalçinkaya
      Abstract: Foreign bodyaspiration is rare in adult patients. The aspirated materials may be of various kinds and may not be diagnosedfor a long period of time.  The patientssometimes are even misdiagnosed and may be treated as asthma, pneumonia, andchronic obstructive pulmonary disease patients. A 72-year-old male patient treated as such was discovered to have aforeign body aspiration 5 years after the incident.  The clinical presentation, history, andtreatment are presented.
      PubDate: Fri, 01 Dec 2017 00:00:00 +030
       
  • Healthy lifestyle behaviours and attitudes of relatives of patients with
           colorectal cancer towards protection from colorectal cancer

    • Authors: Hatice Yüceler Kaçmaz; Gülsüm Nihal Çürük
      Abstract: Aim: Thisstudy was conducted in order to determine healthy lifestyle behaviours andattitudes of first degree relatives of patients with colorectal cancer (CRC)towards protection from CRC. Material and Method:The data were collected by the researcher using Colorectal Cancer ScreeningAttitude Beliefs Scale (CCSAB), and Health Promotion Life-Style Profile II(HPLP). Results:It was found that more than half (56.3%) of the patient relatives did not haveknowledge about CRC and 85.2% did not participate early diagnosis/screeningprograms of CRC. It was found that CCSAB total mean score of the patientrelatives was 53.06±8.91 and HPLP’ total mean score was 132.46±20.96. BothHPLP’ mean score and CCSAB’ mean score was higher in patient’ relatives who hadknowledge about CRC and participated in early diagnosis/screening programs ofCRC and the difference was determined to be highly significant. A positive,weak, and statistically significant correlation was found between CCSAB andHPLP scale of patient relatives in the study. Discussion:The present study showed that the rate of patient relatives to participate inCRC screening participation rates was low, healthy lifestyle behaviours andattitudes towards protection from CRC were moderate. Nurses should raiseawareness through protection from cancer and early diagnosis/screening programsespecially for cancer patients’ relatives in all individuals is at riskprimarily first degree relatives of patients with protection from and beguiding to acquire healthy lifestyle behaviours.
      PubDate: Fri, 01 Dec 2017 00:00:00 +030
       
  • Assessment of the reperfusion success using TIMI Frame score in cases with
           anterior myocardial infarction undergoing thrombus aspirat─▒on

    • Authors: Sezen Uzunget; Orhan Maden, Gizem Çabuk, Eliz Uzel, Mustafa Mücahit Balcı, Zehra Gölbaşı
      Abstract: Background and aim:Achieving reperfusion is the key target in the treatment ofmyocardial infarction with acute ST elevation. In our study, we aimedto compare the improvement in coronary blood flow using correctedTIMI frame score (cTFC) in patients, who presented with acuteanterior ST elevated myocardial infarction (AASTEMI), underwentprimary percutaneous coronary intervention (PPCI) with manualthrombus aspiration (MTA) and those, who underwent PPCI alone.Methods:We included 30 patients with acute AASTEMI, who underwent PPCI withMTA and 60patients, who underwent PPCI alone, between June 2009 and August2013. Coronary angiography images were reviewed after the procedureto evaluate distal embolization, TIMI scores and the corrected TIMIframe scores in both groups. All-cause mortality and stent thrombosiswere recorded at hospital admission. All-cause mortality, stentthrombosis, and hospitalization due to cardiac failure, occurringwithin a month of discharge, were investigated.Results:The mean age was 56.50 ± 16.45 among patients undergoing thrombusaspiration; there were 22 males and 8 females. Among those who didnot undergo MTA, the mean age was 56.57 ± 13.21; and there were 44males and 16females. The rate of previous myocardial infarction (MI) (23.3 % vs6,6 %; p = 0.019) and history of percutaneous coronary intervention(PCI) ( 20.0 % vs 6.7 %, p = 0.040) was higher in patients, whounderwent MTA. The mean TIMI frame score was 28.33 ± 7.24 and 26,68 ± 8,22, respectively in the patients, who underwent and did notundergo MTA; however, no statistically significant difference wasdetected (p = 0.389). Overall time to ischemia was longer in thegroups of patients, who underwent MTA (8.23 ± 9.68 vs 3,68 ± 8,22hours, p = 0.003). Three patients, who underwent MTA (10 %, p =0.007) died before discharge and 1 patients (13.1 %, p = 0.003) diedwithin a month. No cases of death were detected in the group ofpatients, who did not undergo MTA, in the hospital and within amonth. There were no statistically significant differences betweenthese two groups with respect to hospitalization due to cardiacfailure and occurrence of stent thrombosis.Conclusion:The use of MTA in AASTEMI did not have a favorable impact onreperfusion compared to not using MTA.Key words:myocardial infarction, thrombus aspiration, acute anterior myocardialinfarction, percutaneous coronary intervention
      PubDate: Fri, 01 Dec 2017 00:00:00 +030
       
 
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