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LABORATORY AND EXPERIMENTAL MEDICINE (98 journals)

Showing 1 - 98 of 98 Journals sorted alphabetically
AAPS PharmSciTech     Hybrid Journal   (Followers: 10)
Actualites Pharmaceutiques     Full-text available via subscription   (Followers: 7)
Adipocyte     Open Access   (Followers: 1)
African Journal of Laboratory Medicine     Open Access   (Followers: 2)
American Journal of Experimental and Clinical Research     Open Access   (Followers: 4)
American Journal of Medical and Biological Research     Open Access   (Followers: 11)
Animal Models and Experimental Medicine     Open Access  
Annals of Clinical Chemistry and Laboratory Medicine     Open Access   (Followers: 5)
Applied In Vitro Toxicology     Hybrid Journal   (Followers: 2)
Archives of Clinical and Experimental Medicine     Open Access  
Archives of Medical Research     Hybrid Journal   (Followers: 3)
Archives of Pathology & Laboratory Medicine     Full-text available via subscription   (Followers: 32)
Archives of Preventive Medicine     Open Access   (Followers: 3)
Biomedical Engineering     Hybrid Journal   (Followers: 3)
Bulletin of Experimental Biology and Medicine     Hybrid Journal  
Clinica Chimica Acta     Hybrid Journal   (Followers: 30)
Clinical & Experimental Metastasis     Hybrid Journal  
Clinical and Experimental Medical Journal     Full-text available via subscription   (Followers: 1)
Clinical and Experimental Medicine     Hybrid Journal   (Followers: 4)
Clinical Trials     Hybrid Journal   (Followers: 21)
Clinical Trials in Degenerative Diseases     Open Access  
Clinical Trials in Orthopedic Disorders     Open Access   (Followers: 1)
Current Medicine Research and Practice     Full-text available via subscription  
Current Research in Drug Discovery     Open Access   (Followers: 1)
Drug Design, Development and Therapy     Open Access   (Followers: 4)
Ecography     Hybrid Journal   (Followers: 28)
European Journal of Hospital Pharmacy : Science and Practice (EJHP)     Hybrid Journal   (Followers: 9)
European Journal of Medical Research     Open Access   (Followers: 1)
European Journal of Nanomedicine     Hybrid Journal   (Followers: 1)
Experimental & Molecular Medicine     Open Access   (Followers: 1)
Experimental Aging Research: An International Journal Devoted to the Scientific Study of the Aging Process     Hybrid Journal   (Followers: 3)
Experimental and Therapeutic Medicine     Full-text available via subscription   (Followers: 2)
Experimental Biology and Medicine     Hybrid Journal   (Followers: 3)
Expert Opinion on Drug Delivery     Hybrid Journal   (Followers: 20)
Frontiers in Laboratory Medicine     Open Access  
Frontiers in Medical Technology     Open Access   (Followers: 1)
IN VIVO     Full-text available via subscription   (Followers: 5)
International Archives of Biomedical and Clinical Research     Open Access  
International Journal of Experimental Pathology     Hybrid Journal   (Followers: 1)
International Journal of Health Research and Innovation     Open Access   (Followers: 2)
International Journal of Research in Medical Sciences     Open Access   (Followers: 7)
International Journal of Statistics in Medical Research     Hybrid Journal   (Followers: 5)
Journal of Cell Science & Therapy     Open Access   (Followers: 1)
Journal of Applied Biomaterials & Functional Materials     Hybrid Journal   (Followers: 1)
Journal of Biomedical and Clinical Research     Open Access  
Journal of Clinical Laboratory Analysis     Open Access   (Followers: 14)
Journal of Clinical Medicine and Research     Open Access  
Journal of Clinical Medicine Research     Open Access   (Followers: 4)
Journal of Clinical Trials     Open Access   (Followers: 6)
Journal of Current and Advance Medical Research     Open Access   (Followers: 2)
Journal of Current Medical Research and Practice     Open Access  
Journal of Current Research in Scientific Medicine     Open Access  
Journal of Drug Delivery and Therapeutics JDDT     Open Access   (Followers: 1)
Journal of Enzyme Inhibition and Medicinal Chemistry     Open Access   (Followers: 4)
Journal of Experimental & Clinical Medicine     Full-text available via subscription   (Followers: 1)
Journal of Experimental & Clinical Cancer Research     Open Access   (Followers: 2)
Journal of Experimental and Clinical Medicine     Open Access  
Journal of Experimental Medicine     Full-text available via subscription   (Followers: 46)
Journal of Experimental Pharmacology     Open Access   (Followers: 2)
Journal of Histotechnology     Hybrid Journal   (Followers: 2)
Journal of International Medical Research     Open Access   (Followers: 3)
Journal of Investigative Medicine High Impact Case Reports     Open Access  
Journal of Medicine and Biomedical Research     Open Access   (Followers: 1)
Journal of Muhammadiyah Medical Laboratory Technologist     Open Access  
Journal of Operating Department Practitioners     Full-text available via subscription   (Followers: 2)
Journal of the American Society of Cytopathology     Hybrid Journal   (Followers: 5)
Journal of Trace Elements in Medicine and Biology     Hybrid Journal   (Followers: 1)
Lab on a Chip     Full-text available via subscription   (Followers: 43)
Laboratory Investigation     Hybrid Journal   (Followers: 3)
Medical Devices & Sensors     Hybrid Journal  
Medical Image Analysis     Hybrid Journal   (Followers: 15)
Medical Instrumentation     Open Access  
Medical Laboratory Observer     Full-text available via subscription  
Medical Laboratory Technology Journal     Open Access  
Medicinal Chemistry Research     Hybrid Journal   (Followers: 12)
Medtech Insight     Full-text available via subscription   (Followers: 4)
Nanomedicine: Nanotechnology, Biology and Medicine     Hybrid Journal   (Followers: 7)
New Zealand Journal of Medical Laboratory Science     Full-text available via subscription   (Followers: 1)
Oriental Pharmacy and Experimental Medicine     Partially Free   (Followers: 3)
Pathology and Laboratory Medicine International     Open Access   (Followers: 7)
Physical Biology     Hybrid Journal   (Followers: 4)
Practical Laboratory Medicine     Open Access   (Followers: 2)
Proceedings of the Institution of Mechanical Engineers Part H: Journal of Engineering in Medicine     Hybrid Journal   (Followers: 3)
Prosthetics and Orthotics International     Hybrid Journal   (Followers: 10)
Pulse     Full-text available via subscription  
Qualitative Research in Medicine & Healthcare     Open Access  
Recent Advances in Biology and Medicine     Open Access  
Regulatory Toxicology and Pharmacology     Hybrid Journal   (Followers: 43)
Reproduction     Full-text available via subscription   (Followers: 7)
Revista Peruana de Medicina Experimental y Salud Pública     Open Access  
Revista Romana de Medicina de Laborator     Open Access  
RSC Medicinal Chemistry     Full-text available via subscription   (Followers: 6)
SA Pharmacist's Assistant     Open Access  
Savannah Journal of Medical Research and Practice     Full-text available via subscription  
SLAS Technology     Hybrid Journal   (Followers: 2)
Statistics in Medicine     Hybrid Journal   (Followers: 196)
Trends in Molecular Medicine     Full-text available via subscription   (Followers: 14)
Turkish Journal of Clinics and Laboratory     Open Access   (Followers: 1)
Similar Journals
Journal Cover
Journal of Experimental & Clinical Medicine
Number of Followers: 1  
 
  Full-text available via subscription Subscription journal
ISSN (Print) 1878-3317
Published by Elsevier Homepage  [3225 journals]
  • The Closing of the Journal of Experimental and Clinical Medicine: December
           2009 to December 2014
    • Authors: Chuang C. Chiueh
      First page: 171
      Abstract: Publication date: December 2014
      Source:Journal of Experimental & Clinical Medicine, Volume 6, Issue 6
      Author(s): Chuang C. Chiueh


      PubDate: 2014-12-12T19:23:25Z
      DOI: 10.1016/j.jecm.2014.11.001
      Issue No: Vol. 6, No. 6 (2014)
       
  • Trends of Gold Nanoparticle-Based Drug Delivery System in Cancer Therapy
    • Authors: Giimel Ajnai; Amy Chiu; Tzuchun Kan; Chun-Chia Cheng; Teh-Hua Tsai; Jungshan Chang
      Pages: 172 - 178
      Abstract: Publication date: Available online 29 November 2014
      Source:Journal of Experimental & Clinical Medicine
      Author(s): Giimel Ajnai , Amy Chiu , Tzuchun Kan , Chun-Chia Cheng , Teh-Hua Tsai , Jungshan Chang
      Following surgical removal of malignant tumors, chemotherapeutic intervention usually is subsequently applied in patients with advanced stages of cancer. Most chemotherapeutic drugs are intravenously injected into patients, leading to systemic cytotoxicity in organs and tissues, including healthy tissue and tumors. Currently, it has been demonstrated that gold nanoparticles can easily penetrate blood vessels and tissue barriers into tumor foci, which indicates gold nanoparticles as a more effective drug carrier with great merits in reducing cytotoxicity and economic burden in patients. Moreover, gold nanoparticles display several unique characterizations with multiple functions in therapeutics, imaging, and surface modification, suggesting gold nanoparticles may become effective antitumor drug carriers. In this review article, we discuss the limitations and applications of gold nanoparticles in surface modification, targeting strategy, and safety considerations.

      PubDate: 2014-11-30T18:34:42Z
      DOI: 10.1016/j.jecm.2014.10.015
      Issue No: Vol. 6, No. 6 (2014)
       
  • Prevalence of Comorbid Psychiatric Disorders in Children and Adolescents
           with Autism Spectrum Disorder
    • Authors: Luke Y. Tsai
      Pages: 179 - 186
      Abstract: Publication date: Available online 14 November 2014
      Source:Journal of Experimental & Clinical Medicine
      Author(s): Luke Y. Tsai
      This review is based on an extensive literature search to determine the prevalence of comorbid psychiatric disorders in children and adolescents with autism spectrum disorder (ASD) and shows that case reports and clinic- and community-based studies are available with which to assess this prevalence. Attention-deficit/hyperactivity disorder, anxiety disorders, and mood disorders frequently present in children and adolescents with ASD. However, a valid and reliable prevalence of comorbid psychiatric disorders in children and adolescents with ASD has not been established as a result of the limited number and small sample sizes of the reported studies.

      PubDate: 2014-11-18T17:20:51Z
      DOI: 10.1016/j.jecm.2014.10.005
      Issue No: Vol. 6, No. 6 (2014)
       
  • Epidemiology and Prevalence of Bloodstream Infections in a Regional
           Hospital in Northern Taiwan during 2008–2013
    • Authors: Wen-Shyang Hsieh; Yin-Tai Tsai; Wei-Ming Chi; Hsueh-Hsia Wu
      Pages: 187 - 189
      Abstract: Publication date: Available online 30 October 2014
      Source:Journal of Experimental & Clinical Medicine
      Author(s): Wen-Shyang Hsieh , Yin-Tai Tsai , Wei-Ming Chi , Hsueh-Hsia Wu
      Background Diagnosing bloodstream infections (BSIs) is one of the most critical functions of clinical microbiology laboratories. To reveal the prevalence of BSIs in a hospital in Northern Taiwan, which was established in July 2008, we investigated the clinical characteristics of patients with positive blood cultures from July 2008 to December 2013. Methods The medical records of these patients were retrospectively reviewed; in total, 104,641 blood culture sets were collected and analyzed. Results Of these sets, 10.28% revealed growth of microorganisms: 5.48% exhibited growth of a single microorganism; 1.56% exhibited growth of more than one microorganism; and 3.24% exhibited growth of contaminants. Furthermore, the 5,739 monomicrobial isolates included 22.02% of gram-positive cocci; 56.51% of enterobacteriaceae; 7.27% of glucose nonfermentative GNB; 6.22% of yeast; and 6.64% of anaerobic bacteria. Most of the microorganisms were identified as follows: Escherichia coli (33.80%); Staphylococcus aureus (14.20%); Klebsiella pneumoniae (11.41%); Pseudomonas aeruginosa (3.17%); and the Acinetobacter calcoaceticus-Acinetobacter baumannii (Acb) complex (2.68%). Moreover, among the infants aged ≤ 3 months, Group B streptococcus (GBS) and S. aureus were the leading pathogens causing bacteremia, whereas among the 3–12-month and 1–4-year age groups, Salmonella species were the leading pathogens causing bacteremia. The prevalence of S. pneumoniae increased from the 3–12-month age group and reached a peak for the 5–12-year age group. For patients aged >13 years, the most common pathogens were E. coli, S. aureus, and K. pneumoniae. Conclusion We propose that the types and prevalence of BSIs vary according to age groups and exhibit substantial geographical differences.

      PubDate: 2014-10-31T15:57:49Z
      DOI: 10.1016/j.jecm.2014.10.011
      Issue No: Vol. 6, No. 6 (2014)
       
  • Risks of Internet Abnormal Use among Adolescents with Attention Deficit
           Hyperactivity Disorder
    • Authors: Jun-Han Wu; Yue-Cune Chang; Ruu-Fen Tzang
      Pages: 190 - 194
      Abstract: Publication date: Available online 30 October 2014
      Source:Journal of Experimental & Clinical Medicine
      Author(s): Jun-Han Wu , Yue-Cune Chang , Ruu-Fen Tzang
      Purpose This aim of the study is to investigate the risks among adolescents with Attention Deficit Hyperactivity Disorder (ADHD) who developed compulsive internet use (CIU) and those who did not develop CIU. Methods 78 ADHD adolescents completed general demographic questionnaires including body mass index (BMI), subtype, comorbidity, and behavioral problems. The family characteristics included parental ADHD diagnosis, psychiatric symptoms, and media exposure problems were collected. The respondents were categorized as ADHD with CIU or non-CIU group according to the internet addiction cut-off point by standardized measurements of the Chen Internet Addiction Scale (CIAS). Results The results revealed 12.8% of the adolescent ADHD had CIU. The ADHD adolescents who had CIU were characterized by average high height, withdrawal tendency on, having younger aged father, and playing computer games for more than one hour a day. Conclusion More attention is warranted to ADHD adolescents with CIU. The early intervention program is suggested for their social withdrawal tendency.

      PubDate: 2014-10-31T15:57:49Z
      DOI: 10.1016/j.jecm.2014.10.010
      Issue No: Vol. 6, No. 6 (2014)
       
  • Peroxisome Proliferator-activated Receptor Gamma: genetic Polymorphisms
           are not associated with metabolic Syndrome in Taiwan
    • Authors: Fu-Hsiung Su; Mei-Chieh Chen; Chiu-Shong Liu; Yi-Chieh Huang; Cheng-Chieh Lin; Fung-Chang Sung; Chien-Tien Su; Chih-Ching Yeh
      Pages: 195 - 199
      Abstract: Publication date: Available online 30 October 2014
      Source:Journal of Experimental & Clinical Medicine
      Author(s): Fu-Hsiung Su , Mei-Chieh Chen , Chiu-Shong Liu , Yi-Chieh Huang , Cheng-Chieh Lin , Fung-Chang Sung , Chien-Tien Su , Chih-Ching Yeh
      Background Peroxisome proliferator-activated receptor gamma (PPARγ) is one of the transcriptional regulators of adipocyte differentiation; it was suggested to be a candidate gene modulating obesity, insulin resistance, and dyslipidemia. Aim This study explored the association between PPARγ genetic polymorphisms (Pro12Ala and C161T) and the risk of metabolic syndrome (MetS) in Han Taiwanese participants. Methods This cross-sectional study included 346 participants with MetS and 804 without MetS. The parameters for fasting serum concentrations of glucose and lipids were measured. The presence or absence of MetS was determined according to the modified criteria of the third report of the National Cholesterol Education Program’s Adult Treatment Panel (NCEP ATP III). PPARγ genetic polymorphisms were genotyped with real-time polymerase chain reaction. Results Frequencies of the Pro12Ala Ala allele and C161T T allele among non-MetS participants were 5.2% and 26.0%, respectively. The Pro12Ala and C161T polymorphisms were not significantly associated with MetS risk (OR = 0.75, 95% CI = 0.47–1.21 and OR = 0.92, 95% CI = 0.70–1.20). No significant association was observed between haplotypes of the PPARγ gene and MetS risk even following stratification by gender. Conclusion This result suggests that PPARγ C161T and Pro12Ala genetic polymorphisms may not be associated with MetS among Han Taiwanese.

      PubDate: 2014-10-31T15:57:49Z
      DOI: 10.1016/j.jecm.2014.10.013
      Issue No: Vol. 6, No. 6 (2014)
       
  • Efficacy of Long-acting, Injectable Antipsychotics in the Treatment of
           Bipolar Disorders
    • Authors: Shih-Ku Lin
      Pages: 200 - 202
      Abstract: Publication date: Available online 26 November 2014
      Source:Journal of Experimental & Clinical Medicine
      Author(s): Shih-Ku Lin
      Objective Long-acting injectable (LAI) antipsychotic drugs have been used to treat bipolar disorders, especially in patients with poor medication adherence. We used copies of a questionnaire and chart reviews to investigate the outcome of long-term use of LAI antipsychotic drugs in bipolar patients. Methods In this study, the use of LAI antipsychotics, including first-generation LAI (FLAI) antipsychotic drugs and second-generation LAI (SLAI) antipsychotic drugs were studied, to determine their efficacy and side effects. The study group comprised patients with bipolar disorder who were recruited from outpatient clinics at Taipei City Psychiatric Center: 27 patients who received FLAI antipsychotics and 14 patients who received risperidone one of the SLAI antipsychotics. Self-report copies of the questionnaire were gathered, and information from patients' medical records was reviewed and analyzed (n = 41). Results The frequencies (number of times per year) of mood episodes were found to be significantly different before and after the administration of LAI antipsychotic drugs (0.71 ± 0.65 and 0.23 ± 0.43, respectively, p < 0.001). The frequency of hospitalizations was also significantly different (0.57 ± 0.69 and 0.11 ± 0.26, respectively, p < 0.001). Conclusion LAI treatment may decrease the frequency of mood episodes and number of hospitalizations in patients with bipolar disorder.

      PubDate: 2014-11-30T18:34:42Z
      DOI: 10.1016/j.jecm.2014.10.008
      Issue No: Vol. 6, No. 6 (2014)
       
  • Tissue Response to Titanium Implant with Novel Nanoporous Surface
           Functionalization: Orofacial Stress, Primary Stability, and
           Osseointegration
    • Authors: Yi-Chen Chiang; Li-Hsiang Lin; Keng-Liang Ou; Han-Yi Cheng
      Pages: 203 - 208
      Abstract: Publication date: Available online 3 December 2014
      Source:Journal of Experimental & Clinical Medicine
      Author(s): Yi-Chen Chiang , Li-Hsiang Lin , Keng-Liang Ou , Han-Yi Cheng
      Objective The aim of this study was to investigate the stress distributions in a surface-treated dental implant and bone under physiological load. Methods The nanoporous surface-modification films were characterized by scanning electron microscopy to analyze surface morphology. The novel implant surface used in this study was complex and difficult to represent because of limitations in computer performance. However, this complex geometry could be simplified using a nanoporous film to investigate stresses resulting from treatment of surfaces with 0–10-μm thicknesses. Results The study results indicated that the stresses were more uniform in implants coated with nanoporous films that underwent surface treatments, and the stresses were reduced with increasing film thickness. Conclusion These nanoporous surface modifications can be potentially beneficial in reducing the stress in dental implants.

      PubDate: 2014-12-05T18:44:56Z
      DOI: 10.1016/j.jecm.2014.10.012
      Issue No: Vol. 6, No. 6 (2014)
       
  • Endoscopic and Clinical Features of Cytomegalovirus Colitis in Critically
           Ill Patients: A Retrospective Review
    • Authors: Ding-Ek Toh; Chun-Nan Chen; Tze-Sian Chan; Gi-Shih Lien; Fat-Moon Suk
      Pages: 209 - 212
      Abstract: Publication date: Available online 22 November 2014
      Source:Journal of Experimental & Clinical Medicine
      Author(s): Ding-Ek Toh , Chun-Nan Chen , Tze-Sian Chan , Gi-Shih Lien , Fat-Moon Suk
      Background Patients with cytomegalovirus (CMV) colitis have increasingly been recognized among critically ill patients, yet few specific clinical and endoscopic features are known. In this study, we investigated the common clinical and endoscopic features of CMV colitis in critically ill patients. Methods From January 1, 2000 to February 28, 2014, patients with a histopathological diagnosis of CMV colitis were retrospectively reviewed. We reviewed and analyzed the clinical presentation, primary diseases, serum CMV antibody, treatment, mortality, and endoscopic features of these patients. Results Eighteen patients were diagnosed as having CMV colitis and 15 CMV colitis patients were included in this study. The mean age was 65.7 years (range 42–92 years). Bloody diarrhea and persistent diarrhea were the most common initial presentations of CMV, and sepsis was the most common comorbidity found. CMV-IgM was positive in three (17%) patients, and CMV-IgG was positive in 14 (93.3%) patients. All patients received ganciclovir and 11 patients clinically improved. Four (26.6%) patients died and two patients had colon perforation. According to the severity of the diseases, endoscopic presentation of CMV colitis ranged from colonic mucosa edema, loss of vasculature, subepithelial hemorrhage, and circular or geographic ulcers to perforation. Ten (66.7%) patients had multiple ulcers and five (33.3%) patients had a single ulcer. Eleven (73.3%) patients had colitis involving distal to splenic flexure, and four (26.6%) patients had colitis involving the whole colon. Conclusions Critically ill patients who present with bloody stool or persistent diarrhea should be considered for the diagnosis of CMV colitis. The endoscopic presentation of CMV colitis is highly variable. We suggest that the endoscopic manifestation of CMV colitis can be divided into three stages: nonulcerative inflammatory stage, simple ulcerative stage, and complicated ulcerative stage.

      PubDate: 2014-11-22T18:01:24Z
      DOI: 10.1016/j.jecm.2014.10.001
      Issue No: Vol. 6, No. 6 (2014)
       
  • Clinical Manifestations and Risk Factors Influencing Eradication of
           Extensive Multidrug-resistant Acinetobacter baumannii from the Respiratory
           Tract
    • Authors: Tai-Chin Hsieh; Shio-Shin Jean; Fu-Lun Chen; Tsong-Yih Ou; Giueng-Chueng Wang; Wen-Sen Lee
      Pages: 213 - 216
      Abstract: Publication date: Available online 24 November 2014
      Source:Journal of Experimental & Clinical Medicine
      Author(s): Tai-Chin Hsieh , Shio-Shin Jean , Fu-Lun Chen , Tsong-Yih Ou , Giueng-Chueng Wang , Wen-Sen Lee
      Purpose Extensive multidrug-resistant Acinetobacter baumannii (XDRAB) has increasingly emerged as one of the most difficult bacteria to treat in the healthcare setting. In this study, we intended to evaluate the factors affecting eradicating XDRAB from the respiratory tract, clinical manifestations, and treatment outcomes. Methods We retrospectively reviewed the medical records of patients who had XDRAB isolated from the respiratory tract in our medical center from January 1, 2012 to February 28, 2013. Results In total, 87 patients were included in this study. Eradication was achieved in 69 patients (79.3%). The factors that negatively affect eradication of XDRAB by aerosolized colistin therapy for two weeks included: (1) receiving noninvasive mechanical ventilation; (2) being infected/colonized during residency in long-term care facilities; and (3) receiving combination therapy with intravenous tigecycline. The 30-day mortality in patients with versus without eradication was 26.1% versus 55.6%, respectively (p < 0.05), and the in-hospital mortality rate (40.6% vs. 66.7%, p < 0.05), were significantly lower in the eradication group than the noneradication group. Steroid use was associated with significantly higher overall mortality (32% vs. 61%, p < 0.05) in both high and low dose groups. Conclusion XDRAB eradication from the respiratory tract is associated with improved clinical outcomes. Clinicians should be aware of the possible negative effect of combination therapy with aerosolized colistin and tigecycline for eradicating XDRAB.

      PubDate: 2014-11-25T18:25:20Z
      DOI: 10.1016/j.jecm.2014.10.003
      Issue No: Vol. 6, No. 6 (2014)
       
  • Impact of Knowledge and Behavior of Medical Personnel towards Speech
           Therapy for Tracheostomized Patients
    • Authors: Ya-Hui Wang; Cai-Jhen Lu; Kwang-Hwa Chang
      Pages: 217 - 221
      Abstract: Publication date: Available online 22 November 2014
      Source:Journal of Experimental & Clinical Medicine
      Author(s): Ya-Hui Wang , Cai-Jhen Lu , Kwang-Hwa Chang
      Background Tracheostomized patients suffer from communication difficulty, physical pain, swallowing difficulty, and decreased quality of life. In this study, we investigated the current status of communication and swallowing difficulties in tracheostomized patients in Taiwan, and the knowledge of medical personnel about tracheostomized patients and the perceived benefits of referring them to speech therapy. Methods We analyzed both the national data from The Collaboration Center of Health Information Application, and medical insurance data of a medical center in Taipei. We also administered a questionnaire survey to 80 medical personnel before and after an education program was given for patients and medical personnel. Results Treatment referral rates of inpatients with tracheostomy for speech therapy were found to be at 4.87% and 10%, from national and medical center data, respectively, and only a few patients received both communication and swallowing training. Over 50% of the medical personnel never referred any tracheostomized inpatients for speech therapy. The rate of referral was not significantly affected by experience and knowledge of medical personnel of tracheostomy. Conclusion Fundamental education about the availability of speech therapy and speech-language therapists for medical personnel would be the best way to help tracheostomized patients obtain entitled proper speech therapy in Taiwan.

      PubDate: 2014-11-22T18:01:24Z
      DOI: 10.1016/j.jecm.2014.10.004
      Issue No: Vol. 6, No. 6 (2014)
       
  • Role of c-Jun in Tumor Necrosis Factor-Alpha Inhibition of Activin
           A-Mediated Erythroid Gene Expression in Erythroleukemia K562 Cells
    • Authors: Chih-Wei Chen; Ming-Hui Chung; Ju-Ling Chang; Chin-Wei Liu; Huei-Mei Huang
      Pages: 222 - 227
      Abstract: Publication date: Available online 28 November 2014
      Source:Journal of Experimental & Clinical Medicine
      Author(s): Chih-Wei Chen , Ming-Hui Chung , Ju-Ling Chang , Chin-Wei Liu , Huei-Mei Huang
      Background The activation of the tumor necrosis factor-alpha (TNF-α)/nuclear factor kappa B (NF-κB) pathway inhibits the expression of erythroid genes, whereas activin A, a member of the transforming growth factor-β superfamily, induces erythroid differentiation. The effect of TNF-α on activin A-induced erythroid gene expression has not been elucidated. Methods Luciferase reporter assay and reverse transcription-polymerase chain reaction (PCR)/quantitative PCR were used to investigate globin promoter activity and globin gene expression in the hematopoietic progenitor cell line K562, respectively. Results TNF-α inhibited the activin A-induced promoter activity of α-globin and ζ-globin in a concentration-dependent manner in K562 cells. Activin A could reverse the TNF-α-inhibited promoter activity of α-globin and ζ-globin in a concentration-dependent manner. TNF-α decreased the mRNA levels of α-globin, ζ-globin, GATA-1, and NF-E2 p45 induced by activin A. The NF-κB inhibitor, Bay117082, inhibited the TNF-α-increased c-Jun level. NF-κB p65 overexpression increased c-Jun protein and enhanced the TNF-α-increased c-Jun level. Furthermore, TNF-α inhibition of activin A-induced promoter activity and mRNA expression of α-globin and ζ-globin were abolished in cells expressing dominant-negative c-Jun. TNF-α inhibition of activin A-induced mRNA expression of GATA-1 and NF-E2 p45 was also abolished in cells expressing dominant-negative c-Jun. Conclusion TNF-α may inhibit activin A-induced erythroid gene expression via increases of c-Jun in K562 cells.

      PubDate: 2014-11-30T18:34:42Z
      DOI: 10.1016/j.jecm.2014.10.014
      Issue No: Vol. 6, No. 6 (2014)
       
  • Community-acquired Methicillin-resistant Staphylococcus aureus Bacteremia
           in a Young Immunocompetent Patient Complicated by Brain and Spleen
           Abscesses with Abdominal Pain and Obstructive Jaundice
    • Authors: Fu-Lun Chen; Tai-Chin Hsieh; Tsong-Yih Ou; Cheng-En Mei; Wen-Sen Lee
      Pages: 232 - 233
      Abstract: Publication date: Available online 15 November 2014
      Source:Journal of Experimental & Clinical Medicine
      Author(s): Fu-Lun Chen , Tai-Chin Hsieh , Tsong-Yih Ou , Cheng-En Mei , Wen-Sen Lee


      PubDate: 2014-11-18T17:20:51Z
      DOI: 10.1016/j.jecm.2014.10.002
      Issue No: Vol. 6, No. 6 (2014)
       
  • Immunoglobulin G4-related Autoimmune Pancreatitis in a Patient
           Misdiagnosed with Abdominal Pain and Obstructive Jaundice
    • Authors: Chun-Nan Chen; Chun-Jen Chang; Gi-Shih Lien
      Pages: 234 - 235
      Abstract: Publication date: Available online 20 November 2014
      Source:Journal of Experimental & Clinical Medicine
      Author(s): Chun-Nan Chen , Chun-Jen Chang , Gi-Shih Lien


      PubDate: 2014-11-22T18:01:24Z
      DOI: 10.1016/j.jecm.2014.10.006
      Issue No: Vol. 6, No. 6 (2014)
       
  • Endomorphin-1 and Endomorthin-2: Involvement of Endogenous μ-Opioid
           Receptor Ligands in Analgesia, Antinociceptive Tolerance, Antianalgesia,
           and Hyperalgesia
    • Authors: Leon F. Tseng
      Pages: 151 - 156
      Abstract: Publication date: Available online 24 September 2014
      Source:Journal of Experimental & Clinical Medicine
      Author(s): Leon F. Tseng
      Endomorphin-1 (EM-1) and endomorphin-2 (EM-2) are endogenous ligands for μ-opioid receptors. Both EM-1 and EM-2, given supraspinally or spinally, produce potent antinociception (analgesia) in mice and rats, measured by the thermal tail-flick response. The antinociception produced by either EM-1 or EM-2 is mediated by the stimulation of μ-opioid receptors, but not by δ- or κ-opioid receptors. EM-1 or EM-2 given supraspinally stimulates primarily μ-opioid receptors and subsequently releases spinipetal noradrenaline and serotonin, acting on α2-adrenoceptors and serotonin receptors in the spinal cord for producing antinociception. However, the antinociception produced by EM-2, but not by EM-1, also contains an additional component, which is mediated by the release of dynorphin A1–17 and Met-enkephalin acting on κ-opioid receptors and δ2-receptors, respectively, in the spinal cord for producing antinociception. Pretreatment with EM-1 or EM-2, given supraspinally or spinally, attenuates the antinociception (antinociceptive tolerance) produced by EM-1 or EM-2, respectively. Pretreatment with EM-2 attenuates the antinociception produced by EM-1; however, pretreatment with EM-1 does not attenuate the antinociception produced by EM-2 (asymmetric cross-tolerance). The antinociception produced by (–)-morphine given into the ventral periaqueductal gray is attenuated by pretreatment with a subanalgesic dose of EM-1 or EM-2 given into the ventral periaqueductal gray in rats (antianalgesia). The antianalgesia produced by EM-2, but not by EM-1, is mediated by the release of dynorphin A1–17, which antagonizes the analgesic response to (–)-morphine. EM-2, but not EM-1, given into the centromedial amygdala decreases the tail-flick latencies (hyperalgesia) in rats. The hyperalgesia induced by EM-2 from centromedial amygdala is mediated by the release of dynorphin A1–17 acting on N-methyl-D-aspartate receptors. It is therefore proposed that there are two separate subtypes of μ-opioid receptors: μ and μ′. The μ-opioid receptors are stimulated by both EM-1 and EM-2, (–)-morphine, and [D-Ala2,NMePhe4,Gly5-ol]enkephalin, and blocked by D-Pro2-endomorphin-1. The μ′-opioid receptors are stimulated by EM-2 but not by EM-1, and blocked by D-Pro2-endomorphin-2, naloxonazine, and 3-methoxynaltrexone. However, both subtypes of μ-opioid receptors are commonly blocked by β-funaltrexamine, D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2, and (–)-naloxone.

      PubDate: 2014-09-24T22:38:57Z
      DOI: 10.1016/j.jecm.2014.08.001
      Issue No: Vol. 6, No. 5 (2014)
       
  • Bundle Care for Preventing Ventilator-associated Pneumonia at a Medical
           Center: A Preliminary Report
    • Authors: Joyce Kee-Hsin Chen; Tzu-Hsuan Chen; Hsueh-Erh (Sarah) Liu; Ching-Chiu Kao; Chieh Feng (Cliff) Chen; Tsong-Yi Ou; Pei-Chuan Tseng; Ken N. Kuo; Wen-Sen Lee
      Pages: 157 - 160
      Abstract: Publication date: Available online 22 September 2014
      Source:Journal of Experimental & Clinical Medicine
      Author(s): Joyce Kee-Hsin Chen , Tzu-Hsuan Chen , Hsueh-Erh (Sarah) Liu , Ching-Chiu Kao , Chieh Feng (Cliff) Chen , Tsong-Yi Ou , Pei-Chuan Tseng , Ken N. Kuo , Wen-Sen Lee
      Background Ventilator-associated pneumonia (VAP) is a very common nosocomial infection in intensive care units (ICUs). Ventilator-associated pneumonia occurs in a considerable proportion of patients undergoing mechanical ventilation and is associated with substantial morbidity, mortality, and excess cost. Therefore, strategies that effectively prevent VAP are urgently needed. Methods Patients admitted between January 1, 2010 and December 31, 2012 were investigated prospectively for VAP. Patients who were admitted to medical and surgical ICUs required more than 48 hours of mechanical ventilation. To develop evidence-based recommendations for VAP bundle care, we organized a multidisciplinary team that included administrators, infection control professionals, clinicians, and nursing informatics specialists. By April 1, 2011, the VAP bundle care interventions were implemented, and integrated into a clinical informatics system for reminding clinicians to promote compliance in bundle care. Results After implementing VAP bundle care, the incidence of VAP decreased from 1.5% to 0% in both ICUs. The average overall patient-ventilator days were decreased from 1301 person-days per month to 1213 person-days per month in both ICUs. Conclusion Based on our experience, we found that implementing VAP bundle care decreased ventilator days and the incidence of VAP.

      PubDate: 2014-09-24T22:38:57Z
      DOI: 10.1016/j.jecm.2014.08.003
      Issue No: Vol. 6, No. 5 (2014)
       
  • Surgical Treatment of Phyllodes Tumor of the Breast with the Trend
    • Authors: Cheng-Chiao Huang; Tsang-Pai Liu; Shih-Ping Cheng; Yuan-Ching Chang
      Pages: 161 - 165
      Abstract: Publication date: Available online 26 September 2014
      Source:Journal of Experimental & Clinical Medicine
      Author(s): Cheng-Chiao Huang , Tsang-Pai Liu , Shih-Ping Cheng , Yuan-Ching Chang
      Objective Phyllodes tumors are composed of a benign epithelial component and a cellular spindle cell stroma that form a leaf-like structure. The purpose of this study was to define changes in patient characteristics, histopathologic parameters, and the outcome during two periods: before and after the introduction of core needle biopsy for preoperative diagnosis. Methods Records were reviewed of 170 patients with phyllodes tumors who were managed surgically. Patients treated from 1997 to 2004 (n = 101) were compared with patients treated from 2006 to 2013 (n = 69). Results The analysis of the two treatment periods revealed that the tumor size at diagnosis increased from 4.6 cm during the earlier period to 7.0 cm during the recent period (p < 0.05). The number of patients undergoing wide excision significantly increased during the recent period. Multivariate analysis revealed that a positive surgical margin was the only independent predictor of recurrence with an increased hazard of 4.8. Conclusion Wide excision with a clear margin is the first choice of current treatment for phyllodes tumors, even for malignant phyllodes tumors. However, this strategy does not further reduce local recurrence effectively, and core needle biopsy cannot be overstated in avoiding inappropriate initial surgery.

      PubDate: 2014-09-28T23:59:04Z
      DOI: 10.1016/j.jecm.2014.08.002
      Issue No: Vol. 6, No. 5 (2014)
       
  • Necrotizing Fasciitis Caused by Infection with Streptococcus pyogenes
           Harboring emm Genotype 11 and Sequence Type 403
    • Authors: Akiyoshi Shibayama; Mitsugu Tamaki; Haruyuki Nagasawa; Susumu Nakamata; Yoshitaka Nakamori; Haruno Yoshida; Takashi Takahashi
      Pages: 166 - 167
      Abstract: Publication date: Available online 3 October 2014
      Source:Journal of Experimental & Clinical Medicine
      Author(s): Akiyoshi Shibayama , Mitsugu Tamaki , Haruyuki Nagasawa , Susumu Nakamata , Yoshitaka Nakamori , Haruno Yoshida , Takashi Takahashi


      PubDate: 2014-10-04T02:56:28Z
      DOI: 10.1016/j.jecm.2014.07.001
      Issue No: Vol. 6, No. 5 (2014)
       
  • Fatal Varicella Infections in a Young Patient with Systemic Lupus
           Erythematosus
    • Authors: Fu-Lun Chen; Tai-Chin Hsieh; Tsong-Yih Ou; Ying-Hua Shieh; Wen-Sen Lee
      Pages: 168 - 169
      Abstract: Publication date: Available online 22 September 2014
      Source:Journal of Experimental & Clinical Medicine
      Author(s): Fu-Lun Chen , Tai-Chin Hsieh , Tsong-Yih Ou , Ying-Hua Shieh , Wen-Sen Lee


      PubDate: 2014-09-24T22:38:57Z
      DOI: 10.1016/j.jecm.2014.08.004
      Issue No: Vol. 6, No. 5 (2014)
       
  • A Bibliometric Study on Second-generation Antipsychotic Drugs in the
           Asia–Pacific Region
    • Authors: Francisco López-Muñoz; Winston W. Shen; Naotaka Shinfuku; Chi-Un Pae; David J. Castle; Albert K. Chung; Kang Sim; Cecilio Álamo
      Pages: 111 - 117
      Abstract: Publication date: Available online 21 July 2014
      Source:Journal of Experimental & Clinical Medicine
      Author(s): Francisco López-Muñoz , Winston W. Shen , Naotaka Shinfuku , Chi-Un Pae , David J. Castle , Albert K. Chung , Kang Sim , Cecilio Álamo
      In this review, we analyzed the status and changes in the research on second-generation (atypical) antipsychotic drugs in the Asia–Pacific region (i.e., Japan, South Korea, Taiwan, Hong Kong, Singapore, and Australia). We also performed a bibliometric study of the literature in this region on atypical antipsychotic drugs (e.g., clozapine, risperidone, olanzapine, ziprasidone, quetiapine, sertindole, aripiprazole, paliperidone, amisulpride, zotepine, asenapine, iloperidone, lurasidone, perospirone, and blonanserin). We applied bibliometric indicators of production and dispersion (i.e., Price's law on the increase of scientific literature and Bradford's law, respectively). We also calculated the participation index of different countries. The data were also correlated with relevant social and health data from the Asia–Pacific region (e.g., the per capita gross domestic product and total per capita expenditure on health and gross domestic expenditure on research and development). All data are discussed together. We also analyzed the different aspects among the six countries in the region.

      PubDate: 2014-07-26T18:31:28Z
      DOI: 10.1016/j.jecm.2014.06.001
      Issue No: Vol. 6, No. 4 (2014)
       
  • Application of Synovial Fluid Mesenchymal Stem Cells: Platelet-rich Plasma
           Hydrogel for Focal Cartilage Defect
    • Authors: Chih-Wei Chiang; Wei-Chuan Chen; Hsia-Wei Liu; Chih-Hwa Chen
      Pages: 118 - 124
      Abstract: Publication date: Available online 12 July 2014
      Source:Journal of Experimental & Clinical Medicine
      Author(s): Chih-Wei Chiang , Wei-Chuan Chen , Hsia-Wei Liu , Chih-Hwa Chen
      Purpose To evaluate the effectiveness of synovial fluid mesenchymal stem cells (SFMSCs) mixed with platelet-rich plasma (PRP) and thermosensitive hydrogel in the management of porcine articular cartilage defects in vitro and in vivo. Methods The in vitro experiment was designed to evaluate the differential potential of cell-laden PRP composite hydrogels, i.e., porcine SFMSCs plus PRP with thermosensitive hydrogel. The chondrogenic-related gene expressions were evaluated for 3 weeks. For the in vivo experiment, an osteochondral defect was first created in the medial condyle of the porcine femurs, which was filled with PRP composite hydrogel, i.e., PRP with thermosensitive hydrogel, in the right femur. The left femur was embedded with cell-laden PRP composite hydrogel. The gross morphology, microscopic histology, and immunohistological staining were evaluated at 4 weeks and 8 weeks after implantation. Results The in vitro study demonstrated that the cell-laden PRP composite hydrogel appeared to have profound chondrogenic potential. The in vivo study also revealed that the cell-laden PRP composite hydrogels had better therapeutic effects with increased cell growth and maturation of chondrocyte than that of the PRP composite hydrogel only group. Conclusion The SFMSCs with PRP and thermosensitive hydrogel have a great capability for chondrocyte regeneration and maturation.

      PubDate: 2014-07-26T18:31:28Z
      DOI: 10.1016/j.jecm.2014.06.007
      Issue No: Vol. 6, No. 4 (2014)
       
  • Factors Associated with Infant Mortality in Malawi
    • Authors: Peter Austin Morton Ntenda; Kun-Yang Chuang; Fentanesh Nibret Tiruneh; Ying-Chih Chuang
      Pages: 125 - 131
      Abstract: Publication date: Available online 10 July 2014
      Source:Journal of Experimental & Clinical Medicine
      Author(s): Peter Austin Morton Ntenda , Kun-Yang Chuang , Fentanesh Nibret Tiruneh , Ying-Chih Chuang
      Objective Despite the large reduction in infant mortality rates in the last two decades, the burden of infant mortality is still high in Malawi. Because few studies have specifically addressed the determinants of infant mortality in Malawi, this exploratory study identified a series of distal, intermediate, and proximal factors related to infant mortality using a conceptual framework that explains the risk in developing countries. The objective of this study was to examine the effects of family and socioeconomic factors on the risk of an infant dying before the age of 12 months. Methods In this study, we analyzed the 2004 and 2010 data of the Malawi Demographic and Health Surveys. This study adopted a cross-sectional study design involving 4,698 and 12,174 singleton births in the years 2004 and 2010, respectively. Multiple logistic regression models were used to estimate the effects of selected variables on infant mortality. Results In the multivariate logistic regression analyses, women who resided in wealthy urban areas were 58% less likely to report infant deaths than those in rural areas [odds ratio (OR) = 0.48]. Infants who were second or third in birth order were less likely to die before 12 months. However, cesarean section delivery was found to be a risk factor associated with infant mortality in the year 2004 (OR = 1.95). By contrast, women who were in the highest 20% of household wealth, who resided in the northern region, and were in the 20–29 age group were less likely to report infant deaths. However, cesarean section delivery (OR = 1.42), male infants (OR = 1.26), and small size at birth (OR = 1.63) were the significant predictors of infant mortality in the year 2010. Furthermore, the mother's education and household wealth were not significant predictors of infant mortality in Malawi. Conclusion The present study shows that improving the quality of life in rural areas, evenly distributing health care delivery services and other social economic factors across the nation, and improving maternal health care, neonatal care, and nutrient intake could decrease infant mortality in Malawi.

      PubDate: 2014-07-26T18:31:28Z
      DOI: 10.1016/j.jecm.2014.06.005
      Issue No: Vol. 6, No. 4 (2014)
       
  • Protective Effect of Diindolylmethane against N-Butyl-N-(4-hydroxybutyl)
           Nitrosamine-induced Bladder Carcinogenesis
    • Authors: Bhoopathy Prabhu; Ramasamy Padma; Devaraj Alwin; Natesan Pazhanivel; Doraisami Balakrishnan; Sivapatham Sundaresan
      Pages: 132 - 138
      Abstract: Publication date: Available online 31 July 2014
      Source:Journal of Experimental & Clinical Medicine
      Author(s): Bhoopathy Prabhu , Ramasamy Padma , Devaraj Alwin , Natesan Pazhanivel , Doraisami Balakrishnan , Sivapatham Sundaresan
      Background Carcinogenesis involves three distinguishable stages, namely, initiation, promotion, and progression. Chemoprevention is the use of agents to inhibit, reverse, or retard tumorigenesis at the initiation stage itself. Diindolylmethane (DIM) is one such agent. The precursor of DIM, that is, indole-3-carbinol, has been found to have beneficial effects in the treatment of prostate and breast cancers. This study was designed to evaluate the protective role of DIM in bladder carcinogenesis. N-Butyl-N-(4-hydroxybutyl) nitrosamine (BBN) was used as a carcinogen to study the chemopreventive activity of DIM in bladder carcinogenesis. Methods Male Wistar rats (n = 24) were grouped into control and experimental groups and the study was terminated at the 32nd week. Group I rats were treated with 0.05% BBN for 8 weeks. Group II rats were treated with BBN + DIM [DIM (5 mg/kg) treatment was started 1 week prior to the BBN treatment, and it was administered for 8 weeks]. Group III rats were treated with DIM alone. Group IV rats were treated as control. The activity and levels of drug-metabolizing and liver enzymes were measured by standard spectrophotometric procedures. Tissues were stained with hematoxylin and eosin and subjected to histopathological examination. Results Male albino Wistar rats were divided into four groups of six animals each. Rats in Group I received BBN and served as experimental control. Group II rats were treated with BBN along with DIM for the initial 8-week period. During the same period, Group III rats were treated with DIM alone. Group IV rats served as the healthy control. At the end of 32 weeks, bladder tissues were collected and subjected to histopathological examination. Increase in the activities of cytochrome (CYP) P450, CYPb5, and CYP c reductase, nicotinamide adenine dinucleotide phosphate (reduced):quinone oxidoreductase 1, aspartate aminotransaminase, and alanine aminotransaminase and decrease in the activity of glutathione S-transferase were found in experimental rats when compared with control rats. Results of histopathological examination showed that DIM reduced BBN-induced initiation of carcinogenesis such as hyperplasia. Conclusion The results of this study show that DIM inhibited hyperplasia, a condition that reflects the development of initiation of carcinogenesis in an experimental model of nitrosamine-induced bladder carcinogenesis, and this effect of DIM can be attributed to its antioxidant activity and its ability to modulate xenobiotic enzymes.

      PubDate: 2014-07-31T18:49:47Z
      DOI: 10.1016/j.jecm.2014.06.008
      Issue No: Vol. 6, No. 4 (2014)
       
  • The Outcome of Clinical Pharmacists' Interventions in a Taiwanese Hospital
           on Pharmacoeconomics and Cost Avoidance
    • Authors: Tzu-Hsuan Lu; Yen-Ying Lee; Shin-Chia Tsai; Hsiu-Yu Chien; Jui-Chia Chang; Ju-Huei Tseng; Wuan-Jin Leu
      Pages: 139 - 142
      Abstract: Publication date: Available online 17 July 2014
      Source:Journal of Experimental & Clinical Medicine
      Author(s): Tzu-Hsuan Lu , Yen-Ying Lee , Shin-Chia Tsai , Hsiu-Yu Chien , Jui-Chia Chang , Ju-Huei Tseng , Wuan-Jin Leu
      Objective In this study, we indented to evaluate the cost implications after preventing drug adverse events of inpatients by the proper interventions made by clinical pharmacists in a Taiwanese hospital. Methods Five clinical pharmacists who were assigned to intensive care units, neurology, cardiology, and nephrology wards documented all interventions with a standardized form. The data were retrospectively evaluated for the following information: (1) categories of drug-related problems; (2) general descriptions of the interventions; and (3) the clinical outcomes of the pharmacist-provided interventions. These pharmacist-provided interventions were independently reviewed by one clinical pharmacist and one physician to determine the probability that an adverse drug event (ADE) would have occurred without the intervention, the severity of potential ADEs, and the clinical significance of the interventions. The potential cost avoidance of the interventions was estimated calculating the payments for the potential ADEs. Results A total of 460 interventions provided by pharmacists were documented from December 2010 to May 2011. The most commonly documented interventions made by pharmacists were the recommendations of dosage adjustments (48.7%). Approximately, 89.3% of pharmacist recommendations (n = 411) were accepted by physicians in the therapeutic team. The potential cost saving of the documented interventions during a 6-month period was calculated to be between 3,692,019 and 9,110,880 in National Taiwan Dollars (NTD), and the potential benefit:cost ratio was estimated as high as 8.4:1. Conclusion Interventions provided by hospital clinical pharmacists significantly prevented potential ADEs by monitor actively drug therapy and patient safety at the intensive care unit, cardiology, neurology, and nephrology care units. To the best of our knowledge, this is the first study to document the potential cost saving and obtained a benefit:cost ratio of 8.4:1 based on the implementation of a proper medication management and use provided by five clinical pharmacists for 6 months in a Taiwan hospital.

      PubDate: 2014-07-26T18:31:28Z
      DOI: 10.1016/j.jecm.2014.06.002
      Issue No: Vol. 6, No. 4 (2014)
       
  • Risk Factors of Carbapenem-resistant Acinetobacter Baumannii Infection
           among Hospitalized Patients
    • Authors: Yi-Hsuan Chen; Chuang Chin Chiueh; Yuarn-Jang Lee
      Pages: 143 - 146
      Abstract: Publication date: Available online 21 July 2014
      Source:Journal of Experimental & Clinical Medicine
      Author(s): Yi-Hsuan Chen , Chuang Chin Chiueh , Yuarn-Jang Lee
      Objective A very common pan-resistant pathogen in health care-related infections in Taiwan is carbapenem-resistant Acinetobacter baumannii (CRAB), which can increase mortality and health care expenses. Increased resistant bacteria due to increased antimicrobial consumption may be responsible for the soaring percentage (to 70%) of the CRAB infection rate in hospitalized patients. In the present study, we used a case-case-control study in a teaching hospital to investigate factors (especially the prior use of antimicrobials) that affect the development of A. baumannii resistance. Methods This was a case-case-control design and was composed of two parallel age- and gender-matched control groups, and two experimental groups [i.e., the carbapenem-resistant group (n = 73) and the carbapenem-sensitive group (n = 77)]. The primary outcome was to identify common risk factors that induce CRAB in hospitalized patients in a teaching hospital in Taiwan. Results The common risk factors for infection of patients by CRAB and carbapenem-sensitive A. baumannii (CSAB) were previous antimicrobial exposure to piperacillin/tazobactam [odds ratio (OR), 2.5] and amikacin (OR, 2.5), meropenem-treated patients had a 4.99-fold increased risk of CRAB infection, but not CSAB infection, when they were admitted to the hospital within 3 months after the antimicrobial exposure. Diabetic patients were moreover prone to being infected by both CRAB and CSAB with an increased OR of 6.26. Ventilator use increased the OR significantly in CRAB infections and CSAB infections by 13.51-fold and 4.72-fold, respectively. Conclusion This study confirms that prior use of antimicrobials such as piperacillin/tazobactam and amikacin can significantly increase CRAB and CSAB infections in hospitalized patients. The prior use of meropenem increased CRAB infections, but not CSAB infections, in patients who were hospitalized 3 months after the drug exposure. Diabetes and ventilator use were also associated with a high rate of CRAB and CSAB infections.

      PubDate: 2014-07-26T18:31:28Z
      DOI: 10.1016/j.jecm.2014.06.003
      Issue No: Vol. 6, No. 4 (2014)
       
  • A Patient with Obese Hypoventilation Syndrome with Ventilator-associated
           Pneumonia: Brain Mapping and Polysomnography Outcomes
    • Authors: Inampudi Jyothi; Thangavel Mahalingam Vijayakumar; Kammella Ananth Kumar; Rajappan Chandra Satish Kumar; Kaliappan Ilango; Ramkumar Sundaraperumal; Aruna Agrawal; Govind Prasad Dubey
      Pages: 147 - 148
      Abstract: Publication date: Available online 19 July 2014
      Source:Journal of Experimental & Clinical Medicine
      Author(s): Inampudi Jyothi , Thangavel Mahalingam Vijayakumar , Kammella Ananth Kumar , Rajappan Chandra Satish Kumar , Kaliappan Ilango , Ramkumar Sundaraperumal , Aruna Agrawal , Govind Prasad Dubey


      PubDate: 2014-07-26T18:31:28Z
      DOI: 10.1016/j.jecm.2014.06.004
      Issue No: Vol. 6, No. 4 (2014)
       
  • Recurrent Complication of Simple and Superficial Pacemaker Pocket
           Infection Caused by Staphylococcus Lugdunensis
    • Authors: Weng-Chio Tam; Ho-Shun Cheng; Shao-Jung Li; Ming-Hsiung Hsieh
      Pages: 149 - 150
      Abstract: Publication date: Available online 12 July 2014
      Source:Journal of Experimental & Clinical Medicine
      Author(s): Weng-Chio Tam , Ho-Shun Cheng , Shao-Jung Li , Ming-Hsiung Hsieh


      PubDate: 2014-07-26T18:31:28Z
      DOI: 10.1016/j.jecm.2014.06.006
      Issue No: Vol. 6, No. 4 (2014)
       
  • Epigenomics of Alzheimer's Disease
    • Authors: Ramón Cacabelos; Clara Torrellas; Francisco López-Muñoz
      Pages: 75 - 82
      Abstract: Publication date: Available online 29 April 2014
      Source:Journal of Experimental & Clinical Medicine
      Author(s): Ramón Cacabelos , Clara Torrellas , Francisco López-Muñoz
      Alzheimer's disease (AD) is a polygenic/complex disorder in which genomic, epigenomic, and environmental factors are involved. Epigenetic factors have emerged as important mediators of aging, neurodegeneration, and brain disorders. Epigenomic changes underlying the phenotypic expression of AD, represented by deposits of extracellular Aβ aggregates in senile plaques, intracellular neurofibrillary tangles, neuronal loss, dendritic desarborization, and neurochemical alterations, are candidate targets for therapeutic intervention. Changes in DNA methylation, histone modifications, chromatin remodeling, and noncoding RNA dysregulation can affect AD-related gene expression, leading to the multistep process of premature neurodegeneration. Epigenetic modifications are reversible and can be potentially targeted by pharmacological and dietary interventions.

      PubDate: 2014-04-29T16:16:05Z
      DOI: 10.1016/j.jecm.2014.03.010
      Issue No: Vol. 6, No. 3 (2014)
       
  • Effect of Ketamine on the Quality of Anesthesia and Postoperative
           Analgesia in Epidural Anesthesia
    • Authors: İbrahim Mustafa Erol; Levent Özdoğan; Dilşen Örnek; Vildan Taşpınar; Dilek Kalaycı; Semiha Barçın; Fazilet Şahin; Gülcan Erk; Bayazit Dikmen
      Pages: 83 - 89
      Abstract: Publication date: Available online 5 May 2014
      Source:Journal of Experimental & Clinical Medicine
      Author(s): İbrahim Mustafa Erol , Levent Özdoğan , Dilşen Örnek , Vildan Taşpınar , Dilek Kalaycı , Semiha Barçın , Fazilet Şahin , Gülcan Erk , Bayazit Dikmen
      Purpose To investigate the effects of adding ketamine to the epidural anesthesia over quality of intraoperative anesthesia and postoperative analgesia. Methods Sixty adult patients, 20–70 yr with an American Society of Anesthesiologists physical status of I-III (ASA I-III) who were scheduled for total hip arthroplasty were enrolled. A 18-gauge epidural needle from the L4-5 space in addition to bupivacaine 75 mg; fentanyl 100 mcg was delivered in Group BF, ketamine 30 mg in Group BK, and fentanyl 100 μg plus ketamine 30 mg in Group BKF. Onset time of sensory block, start time of surgery, maximal sensory block level, time to two-segment regression, length of anesthesia, motor block level, quality of anesthesia, and patient satisfaction were determined. At the end of the operation, analgesia was achieved by patient-controlled analgesia method. Time to first analgesic requirement, morphine consumption at 24 hours, number of requests for additional analgesic, and the amount of delivered bolus solution, were noted. Results There was no statistically significant difference between the groups with regard to onset time of sensory block and length of surgery. Start time of surgery was significantly shorter in Group BKF; and time to two-segment regression, length of anesthesia, and time to first analgesic requirement were significantly longer in Group BF. Morphine consumption at 24 hours, number of requests for additional analgesic, and the amount of delivered analgesic bolus were minimal in Group BKF. Conclusion Epidural ketamine shortened the start time of surgery by reducing the onset time of block and elevating the maximal block level.

      PubDate: 2014-05-09T11:26:20Z
      DOI: 10.1016/j.jecm.2014.02.008
      Issue No: Vol. 6, No. 3 (2014)
       
  • Hospital-acquired Urinary Tract Infections in Patients with Diabetes and
           Urinary Catheterization
    • Authors: Lin-Fang Chen; Tsong-Yih Ou; Sing-On Teng; Fu-Lun Chen; Tai-Chin Hsieh; Wen-Sen Lee
      Pages: 90 - 93
      Abstract: Publication date: Available online 24 May 2014
      Source:Journal of Experimental & Clinical Medicine
      Author(s): Lin-Fang Chen , Tsong-Yih Ou , Sing-On Teng , Fu-Lun Chen , Tai-Chin Hsieh , Wen-Sen Lee
      Objective Urinary tract infection (UTI) is the most common hospital-acquired infection. Foley catheter-related UTI is associated with increased mortality, morbidity, length of hospital stay, and costs. Few studies have compared the pathogens by bacterial strains, resistance to antibiotics, comorbidities, and related risk factors in hospital-acquired UTI patients with or without diabetes and with or without a Foley catheter. The objective of this study was to compare the variables of hospital-acquired UTI between these two groups. Methods In this retrospective chart review study, we included hospital-acquired UTI patients (hospitalization time > 48 hours) with either diabetes or a Foley catheter from a medical center in Taipei (Taiwan) between January 1, 2011 and December 31, 2012. We excluded patients with positive urine culture for bacteria within 48 hours of admission. Clinically related information was collected using case data sheets. Results We analyzed 595 patients with hospital-acquired UTI; the infection rate of hospital-acquired UTI in our study was significantly higher in patients with a urinary catheter (n = 497) than in those without (p < 0.05). Regardless of the status of diabetes, all hospital-acquired UTI patients with a urinary catheter had higher mortality (27% vs. 19%) and bloodstream infection rates (14% vs. 9%) than those without a urinary catheter. Predictably, both groups (i.e., groups with and without a urinary catheter) had more Gram-negative strains, with Escherichia coli, Pseudomonas aeruginosa, and Klebsiella pneumoniae being the most commonly isolated pathogens. The fungal infection rate was significantly higher in the urinary catheter group than in the nonurinary catheter group (37% vs. 25%; p < 0.05). Among the 78 pathogenic strains isolated from patients who died, the microorganisms found were fungi (39%), Gram-negative bacteria (31%), and Gram-positive bacteria (8%). Of the patients with a urinary catheter, age, length of hospital stay, number of comorbidities, and duration of infection after admission were all significantly higher in the diabetic group than in the nondiabetic group (p < 0.05). Conclusion Unlike having diabetes, having a urinary catheter was a significant risk factor for hospital-acquired UTI (p < 0.001). However, diabetic patients with a urinary catheter had a longer length of hospital stay than those without a urinary catheter. The resistance rate of E. coli to first-generation cephalosporins was higher in diabetic patients with a urinary catheter. Fungal infections, renal insufficiency, and cerebral vascular accident were significantly (p < 0.01) related risk factors for mortality. Candida deaths outnumbered other bacterial infections, and fungal UTI was the most prominent infection in nosocomial urinary catheterized patients.

      PubDate: 2014-05-24T21:24:09Z
      DOI: 10.1016/j.jecm.2014.04.001
      Issue No: Vol. 6, No. 3 (2014)
       
  • Preliminary Study of the Effect of Use of Antibiotic Ointment on Nasal
           Packings: Is it Effective in Reducing Postoperative Nasal Bacterial
           Loads'
    • Authors: Po-Yueh Chen; Kuei Chen; Pin-Zhi Chao; Hsin-Te Hsu; Shih-Han Hung
      Pages: 94 - 97
      Abstract: Publication date: Available online 3 May 2014
      Source:Journal of Experimental & Clinical Medicine
      Author(s): Po-Yueh Chen , Kuei Chen , Pin-Zhi Chao , Hsin-Te Hsu , Shih-Han Hung
      Nasal packing is a widely used procedure in various types of nasal surgery and the management of nasal bleeding. The purpose of this study was to evaluate a simple procedure of applying antibiotic ointment to the surface of the packing during the packing procedure. Six patients who were undergoing septomeatoplasty were enrolled in this study. All patients received postoperative antibiotics by mouth (cephalexin 500 mg 4 times daily for 7 days). In addition, all patients received bilateral nasal packing with Merocele. On one randomly chosen side, ointment containing neomycin sulfate 5 mg plus bacitracin zinc 12.5 mg was applied on the surface of the packing prior to use. On the control side of the same patient, Vaseline ointment was used instead. The packs were removed 3 days later and a 1 cm3 piece of the packing was taken from the middle section. The samples were sent for bacteriological analysis. Tryptic soy broth was added to the samples and they were evenly dispersed on blood agar plates. After incubating overnight, colony formation was observed and recorded. The data from each group were compared using the Wilcoxon signed rank test. Among the control nasal packing side, Pseudomonas putida and Staphylococcus epidermidis were the bacteria most commonly cultured. The mean ± SD number of colony-forming units for the removed nasal packing (n = 6) on the neomycin side and the control side of the same patient were 70 ± 105 units and 165 ± 166 units, respectively. In addition to the systemic administration of antibiotics, a significant reduction in bacterial load was achieved if a topical neomycin antibiotic ointment was applied to the nasal packing prior to use. We suggest that this simple application of topical neomycin on the nasal packing surface should be used whenever nasal packing is needed.

      PubDate: 2014-05-04T16:23:02Z
      DOI: 10.1016/j.jecm.2014.03.002
      Issue No: Vol. 6, No. 3 (2014)
       
  • Erlotinib Had No Cholinergic Effects on Tracheal Smooth Muscle
    • Authors: Chih-Cheng Chang; Hsiao-Chi Chuang; Chun-Nin Lee; Wen-Yueh Hung; Hsing-Won Wang
      Pages: 98 - 101
      Abstract: Publication date: Available online 5 May 2014
      Source:Journal of Experimental & Clinical Medicine
      Author(s): Chih-Cheng Chang , Hsiao-Chi Chuang , Chun-Nin Lee , Wen-Yueh Hung , Hsing-Won Wang
      Erlotinib (Tarceva) is an oral epidermal growth factor receptor-tyrosine kinase inhibitor that is mainly used for patients with advanced or metastatic non-small-cell lung cancer. Tyrosine kinase signaling cascades also play a critical role in the pathogenesis of allergic airway inflammation and airway remodeling. However, cholinergic effects caused by erlotinib on tracheal smooth muscle remain unclear. The objective of this study was to determine the effects of erlotinib on the isolated rat tracheal smooth muscle in vitro. To examine the cholinergic effects of erlotinib, in vitro rat tracheal smooth muscle was used to assess alterations in methacholine-induced contraction (served as a parasympathetic mimetic) and electrically induced contraction. The results demonstrated that the addition of erlotinib (from 1 × 10−8M to 1 × 10−4M) induced no significant effects on tracheal tension after methacholine treatment. Furthermore, erlotinib did not affect electrical field stimulation-induced spike contraction. This study demonstrated that erlotinib had no cholinergic effects in vitro, suggesting it may be safe for asthmatic patients with non-small-cell lung cancer after further investigation.

      PubDate: 2014-05-09T11:26:20Z
      DOI: 10.1016/j.jecm.2014.03.007
      Issue No: Vol. 6, No. 3 (2014)
       
  • Influence of Demographic Status on Pulmonary Function, Quality of Life,
           and Symptom Scores in Patients with Mild to Moderate Persistent Asthma
    • Authors: M.G. Rajanandh; A.D. Nageswari; K. Ilango
      Pages: 102 - 104
      Abstract: Publication date: Available online 9 May 2014
      Source:Journal of Experimental & Clinical Medicine
      Author(s): M.G. Rajanandh , A.D. Nageswari , K. Ilango
      The association of patient factors such as age, gender, smoking status, asthma duration, and literacy with pulmonary function, quality of life, and symptom scores was examined. Two hundred and forty-two patients were included in this study. Pulmonary function was measured by spirometry and data on the patients' health-related quality of life and asthma symptom scores were obtained from questionnaires. After the drug treatment, younger asthmatics, particularly male patients showed statistically significant (p < 0.05) improvement in pulmonary function, day-time and night-time symptom score. Patients with an asthma duration of ≤5 years showed a significant improvement in pulmonary function and health-related quality of life scores (p < 0.05). Nonsmokers and literate patients had a significantly higher improvement in pulmonary function than smokers and illiterate patients (p < 0.05). Demographic factors were independently associated with asthma efficacy parameters. We encourage further studies on the underlying pathways and public health interventions, focusing on reducing socio-demographic inequalities in patients with asthma.

      PubDate: 2014-05-14T00:29:21Z
      DOI: 10.1016/j.jecm.2014.03.008
      Issue No: Vol. 6, No. 3 (2014)
       
  • Endobronchial Cryptococcosis in a Non-HIV Immunocompromised Patient
    • Authors: Chise Sugita; Sawako Tanaka; Takashi Takahashi
      Pages: 105 - 106
      Abstract: Publication date: Available online 5 May 2014
      Source:Journal of Experimental & Clinical Medicine
      Author(s): Chise Sugita , Sawako Tanaka , Takashi Takahashi


      PubDate: 2014-05-09T11:26:20Z
      DOI: 10.1016/j.jecm.2014.03.004
      Issue No: Vol. 6, No. 3 (2014)
       
  • Zinc-Finger Nucleases and their Application in the Treatment of Genetic
           Diseases
    • Authors: Muhammad Saad Farooq; Muhammad Zain Farooq
      First page: 107
      Abstract: Publication date: Available online 3 May 2014
      Source:Journal of Experimental & Clinical Medicine
      Author(s): Muhammad Saad Farooq , Muhammad Zain Farooq


      PubDate: 2014-05-04T16:23:02Z
      DOI: 10.1016/j.jecm.2014.03.005
      Issue No: Vol. 6, No. 3 (2014)
       
  • Breakthrough Trichosporon asahii Fungemia during Caspofungin Therapy
    • Authors: Wen-Sen Lee; Fang-Lan Yu; Tsong-Yih Ou; Fu-Lun Chen; Shio-Shin Jean; Chin-Wang Hsu
      Pages: 108 - 109
      Abstract: Publication date: Available online 29 April 2014
      Source:Journal of Experimental & Clinical Medicine
      Author(s): Wen-Sen Lee , Fang-Lan Yu , Tsong-Yih Ou , Fu-Lun Chen , Shio-Shin Jean , Chin-Wang Hsu


      PubDate: 2014-04-29T16:16:05Z
      DOI: 10.1016/j.jecm.2014.03.009
      Issue No: Vol. 6, No. 3 (2014)
       
  • Corrigendum to ‘‘Detecting Interleukin-1β Genes Using a N2O Plasma
           Modified Silicon Nanowire Biosensor’’ [J Exp Clin Med
           2013;5(1):12–16]
    • Authors: Chia-Yu Wu; Ching-Li Tseng; Yang-Kao Wang; Yvonne Yu; Keng-Liang Ou; Chi-Chang Wu
      First page: 110
      Abstract: Publication date: Available online 21 April 2014
      Source:Journal of Experimental & Clinical Medicine
      Author(s): Chia-Yu Wu , Ching-Li Tseng , Yang-Kao Wang , Yvonne Yu , Keng-Liang Ou , Chi-Chang Wu


      PubDate: 2014-04-24T16:51:44Z
      DOI: 10.1016/j.jecm.2014.03.001
      Issue No: Vol. 6, No. 3 (2014)
       
  • Nerve Excitability Changes in Chronic Inflammatory Demyelinating
           Polyneuropathy: A New Clinical Diagnostic Biomarker
    • Authors: Jowy Tani; Chin-I Chen; Jia-Ying Sung
      Pages: 43 - 49
      Abstract: Publication date: Available online 18 March 2014
      Source:Journal of Experimental & Clinical Medicine
      Author(s): Jowy Tani , Chin-I Chen , Jia-Ying Sung
      The diagnosis of chronic inflammatory demyelinating polyneuropathy (CIDP) mainly relies on clinical presentation and traditional nerve conduction studies. However, diagnosing CIDP with an atypical presentation remains a challenge. Availability of an additional diagnostic utility, such as the nerve excitability test (NET), can improve clinicians' ability to diagnose CIDP. In this article, we present a review of published papers on the changes in nerve excitability parameters in CIDP. Among the nerve excitability parameters, a baseline increase of the threshold current in a stimulus–response curve, decreased strength–duration time constant, and “fanning-out” pattern of the threshold electrotonus are consistently noted. The recovery cycle might show increased superexcitability and the current–voltage relationship might show inward rectification, but these changes are less consistently noted. These parameters are compatible with membrane hyperpolarization in CIDP. On longitudinal follow-up, normalization of nerve excitability parameters is noted after intravenous immunoglobulin treatment. We also report a case of acute-onset focal CIDP with a longitudinal nerve excitability study, where nerve excitability changes consistent with previous studies have enabled early diagnosis. NET may be a useful tool for clinical neurophysiologists for early diagnosis and follow-up of CIDP.

      PubDate: 2014-03-18T16:47:16Z
      DOI: 10.1016/j.jecm.2014.02.011
      Issue No: Vol. 6, No. 2 (2014)
       
  • Relationship of Cytokines to Symptom Distress and Symptom Clusters among
           Non-Small-Cell Lung Cancer Patients Receiving Gefitinib Treatment: A Pilot
           Study
    • Authors: Shu-Yi Wang; Chun-Ming Tsai; Chia-Chin Lin
      Pages: 50 - 56
      Abstract: Publication date: Available online 22 March 2014
      Source:Journal of Experimental & Clinical Medicine
      Author(s): Shu-Yi Wang , Chun-Ming Tsai , Chia-Chin Lin
      Purpose Several cytokines involved in the development of sickness behaviors are considered to be related to the development of cancer symptoms. However, the mechanism of cytokines' involvement in symptom relief with gefitinib treatment remains unknown. This study analyzed the relationships between single symptoms/symptom clusters and cytokines in patients with advanced non-small-cell lung cancer (NSCLC) at pretreatment and at 1 month, 3 months, and 6 months after gefitinib treatment. Methods Fifty-seven patients with NSCLC were recruited via convenience sampling from a group of thoracic oncology patients in Northern Taiwan. Research measures included the use of the M.D. Anderson Symptom Inventory—Taiwan form and enzyme-linked immunosorbent assays. Statistical analyses included descriptive statistics and generalized estimating equation analysis. Results Positive relationships were observed between interleukin (IL)-2 and nausea (p = 0.004), distress (p = 0.012), drowsiness (p = 0.009), lack of appetite (p = 0.010), sum of symptom severity scores (p = 0.004), and a gastrointestinal symptom cluster (p = 0.004). Positive relationships between IL-6 and sadness (p = 0.020), lack of appetite (p = 0.012), and pain (p = 0.014), and a negative relationship between IL-6 and difficulty remembering (p = −0.013) were also observed. In addition, positive relationships were observed between IL-10 and fatigue (p = 0.005), lack of appetite (p = 0.007), drowsiness (p = 0.006), sadness (p = 0.014), sum of symptom severity scores (p = 0.003), and a general symptom cluster (p = 0.004). Conclusion These results may provide a basis for understanding possible mechanisms of symptom distress in patients with NSCLC; this may possibly lead to the identification of a target for effective symptom management, i.e., focusing on the inflammation pathway for the treatment of detrimental effects of cytokine-induced inflammatory responses.

      PubDate: 2014-03-24T00:09:44Z
      DOI: 10.1016/j.jecm.2014.02.009
      Issue No: Vol. 6, No. 2 (2014)
       
  • Interleukin-21 Receptor might be a Novel Therapeutic Target for the
           Treatment of Rheumatoid Arthritis
    • Authors: Farhad Seif; Majid Khoshmirsafa; Mohammad Mousavi; Pezhman Beshkar; Mahmoud Rafeian-Kopaei; Nader Bagheri; Hedayatollah Shirzad
      Pages: 57 - 61
      Abstract: Publication date: Available online 21 March 2014
      Source:Journal of Experimental & Clinical Medicine
      Author(s): Farhad Seif , Majid Khoshmirsafa , Mohammad Mousavi , Pezhman Beshkar , Mahmoud Rafeian-Kopaei , Nader Bagheri , Hedayatollah Shirzad
      Background Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by the synovial inflammation of the joints. Various cells and cytokines have been identified that may contribute to RA pathology. Interleukin (IL)-21 is a proinflammatory cytokine mediating pleiotropic functions through the IL-21 receptor (IL-21R). Blockade of IL-21R may represent a hopeful therapeutic approach in RA. The aim of this study was to determine the percentage of IL-21R expressing CD4+ cells and IL-21 mRNA expression in peripheral blood of RA patients. Methods Surface expression of IL-21R on CD4+ cells in peripheral blood of RA patients (n = 32 compared to healthy control participants (n = 20) was evaluated by flow cytometry. Simultaneously, mononuclear cells were taken apart from the peripheral blood of individuals on a density gradient. The expression of IL-21 mRNA was assessed by real-time polymerase chain reaction. Results IL-21R-expressing CD4+ cells from RA patients showed a significantly higher percentage of IL-21R compared with healthy controls (p = 0.001). Moreover, real-time polymerase chain reaction showed that there was no significant difference between patients and healthy controls. Conclusion Our results indicate higher expression of IL-21R in RA patients and suggest that targeting of the IL-21R may be a novel therapeutic idea for the treatment of RA.

      PubDate: 2014-03-24T00:09:44Z
      DOI: 10.1016/j.jecm.2014.02.010
      Issue No: Vol. 6, No. 2 (2014)
       
  • AIDS-Related Gastric Kaposi's Sarcoma Before and After Treatment with
           Pegylated Liposomal Doxorubicin
    • Authors: Takashi Takahashi; Aikichi Iwamoto
      Pages: 62 - 63
      Abstract: Publication date: Available online 18 March 2014
      Source:Journal of Experimental & Clinical Medicine
      Author(s): Takashi Takahashi , Aikichi Iwamoto


      PubDate: 2014-03-18T16:47:16Z
      DOI: 10.1016/j.jecm.2014.02.001
      Issue No: Vol. 6, No. 2 (2014)
       
  • A Growing Mass in the Mediastinum: Hiatus Hernia
    • Authors: Takashi Takahashi; Masashi Okuro; Kunimitsu Iwai; Shigeto Morimoto
      Pages: 64 - 65
      Abstract: Publication date: Available online 17 March 2014
      Source:Journal of Experimental & Clinical Medicine
      Author(s): Takashi Takahashi , Masashi Okuro , Kunimitsu Iwai , Shigeto Morimoto


      PubDate: 2014-03-18T16:47:16Z
      DOI: 10.1016/j.jecm.2014.02.002
      Issue No: Vol. 6, No. 2 (2014)
       
  • Brugada Syndrome in a Patient with Complete Right Bundle Branch Block
    • Authors: Cheng-Yen Chuang; Ho-Shun Cheng; Pai-Fung Kao; Ming-Hsiung Hsieh
      Pages: 66 - 67
      Abstract: Publication date: Available online 17 March 2014
      Source:Journal of Experimental & Clinical Medicine
      Author(s): Cheng-Yen Chuang , Ho-Shun Cheng , Pai-Fung Kao , Ming-Hsiung Hsieh


      PubDate: 2014-03-18T16:47:16Z
      DOI: 10.1016/j.jecm.2014.02.003
      Issue No: Vol. 6, No. 2 (2014)
       
  • Severe Mycoplasma pneumoniae Infection Complicating Septic Encephalopathy
           and Seizure Attacks
    • Authors: Wen-Sen Lee; Tsong-Yih Ou; Fu-Lun Chen; Chin-Wang Hsu; Shio-Shin Jean
      Pages: 68 - 69
      Abstract: Publication date: Available online 26 March 2014
      Source:Journal of Experimental & Clinical Medicine
      Author(s): Wen-Sen Lee , Tsong-Yih Ou , Fu-Lun Chen , Chin-Wang Hsu , Shio-Shin Jean


      PubDate: 2014-03-29T15:16:00Z
      DOI: 10.1016/j.jecm.2014.02.004
      Issue No: Vol. 6, No. 2 (2014)
       
  • Epistaxies from a Pyogenic Granuloma of Nasal Septum
    • Authors: Hsing-Won Wang; Tsung-Wei Liu; Pin-Zhir Chao; Chia-Yang Shiau
      Pages: 70 - 71
      Abstract: Publication date: Available online 21 March 2014
      Source:Journal of Experimental & Clinical Medicine
      Author(s): Hsing-Won Wang , Tsung-Wei Liu , Pin-Zhir Chao , Chia-Yang Shiau


      PubDate: 2014-03-24T00:09:44Z
      DOI: 10.1016/j.jecm.2014.02.005
      Issue No: Vol. 6, No. 2 (2014)
       
  • Title Index
    • Abstract: Publication date: December 2014
      Source:Journal of Experimental & Clinical Medicine, Volume 6, Issue 6


      PubDate: 2014-12-12T19:23:25Z
       
  • Combined Cervical Cord and Bilateral Cerebellar Infarction: A Case Report
    • Authors: Hung-Ju Chen; Chih-Shan Huang
      Abstract: Publication date: Available online 4 November 2014
      Source:Journal of Experimental & Clinical Medicine
      Author(s): Hung-Ju Chen , Chih-Shan Huang


      PubDate: 2014-11-05T16:05:12Z
       
  • Streptococcus parasanguinis Co-infection with Escherichia coli Bacteremia
           in a Patient with Complicated Urinary Tract Infection
    • Authors: Wen-Sen Lee; Fang-Lan Tai-Chin Hsieh Tsong-Yih Fu-Len Cheng Shio-Shin Jean
      Abstract: Publication date: Available online 30 October 2014
      Source:Journal of Experimental & Clinical Medicine
      Author(s): Wen-Sen Lee , Fang-Lan Yu , Tai-Chin Hsieh , Tsong-Yih Ou , Fu-Len Cheng , Shio-Shin Jean , Chin-Wang Hsu


      PubDate: 2014-10-31T15:57:49Z
       
 
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