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Laboratory Investigation
Journal Prestige (SJR): 1.883

Citation Impact (citeScore): 4
Number of Followers: 3

Hybrid journal (It can contain Open Access articles)
ISSN (Print) 0023-6837 - ISSN (Online) 1530-0307
Published by NPG

[138 journals]

Artificial intelligence and computational pathology
- Laboratory Investigation, Published online: 16 January 2021; doi:10.1038/s41374-020-00514-0
  Data processing and learning has become a spearhead for the advancement of medicine. Computational pathology is burgeoning subspecialty that promises a better-integrated solution to whole-slide images, multi-omics data and clinical informatics as innovative approach for patient care. This review describes clinical perspectives and discusses the statistical methods, clinical applications, potential obstacles, and future directions of computational pathology.Laboratory Investigation, Published online: 2021-01-16; doi:10.1038/s41374-020-00514-02021-01-16
  DOI: 10.1038/s41374-020-00514-0
Generation of a new immortalized human lung pericyte cell line: a
promising tool for human lung pericyte studies
- Laboratory Investigation, Published online: 14 January 2021; doi:10.1038/s41374-020-00524-y
  Recent studies highlight a prominent role of human lung pericytes in lung diseases. However, human lung pericytes usually stop growth within ten passages. This study successfully established an immortalized human lung pericyte cell line, which exhibited sustained proliferation, retained pericyte characteristics and function, is a promising tool for in vitro pericyte studies.Laboratory Investigation, Published online: 2021-01-14; doi:10.1038/s41374-020-00524-y2021-01-14
  DOI: 10.1038/s41374-020-00524-y
Exosomes derived from hypoxic glioma deliver miR-1246 and miR-10b-5p to
normoxic glioma cells to promote migration and invasion
- Laboratory Investigation, Published online: 14 January 2021; doi:10.1038/s41374-020-00522-0
  In this study, the authors reveal that the hypoxic microenvironment stimulates glioma to generate miR-1246- and miR-10b-5p-rich exosomes, which are delivered to normoxic glioma cells to promote their migration and invasion by targeting FRK and TFAP2A respectively. Treatment targeting the exosomes and microRNAs may impair the motility of gliomas, providing a novel direction for the development of antitumor therapy.Laboratory Investigation, Published online: 2021-01-14; doi:10.1038/s41374-020-00522-02021-01-14
  DOI: 10.1038/s41374-020-00522-0
Large-scale, three-dimensional tissue cytometry of the human kidney: a
complete and accessible pipeline
- Laboratory Investigation, Published online: 06 January 2021; doi:10.1038/s41374-020-00518-w
  Tissue cytometry is a promising new microscopy technique that can be used to enumerate and characterize each cell in a tissue. Here the authors describe a complete and accessible pipeline, including methods of sample preparation, microscopy, image analysis, and data analysis for large-scale three-dimensional tissue cytometry of human kidney tissues.Laboratory Investigation, Published online: 2021-01-06; doi:10.1038/s41374-020-00518-w2021-01-06
  DOI: 10.1038/s41374-020-00518-w
Extracellular vesicles derived from miR-199a-5p-modified adipose-derived
mesenchymal stem cells alleviate immune thrombocytopenia by inhibiting T
helper 17 differentiation
- Laboratory Investigation, Published online: 05 January 2021; doi:10.1038/s41374-020-00515-z
  The abnormal differentiation of Th17 cells is a vital promoter of immune thrombocytopenia (ITP) progression. In this study, the authors found that miR-199a-5p is downregulated during ITP. Supplementation of extracellular vesicles (EVs) derived from miR-199a-5p-modified ADSCs markedly repress Th17 differentiation by transferring miR-199a-5p to CD4+T cells, thus ameliorating experimental ITP.Laboratory Investigation, Published online: 2021-01-05; doi:10.1038/s41374-020-00515-z2021-01-05
  DOI: 10.1038/s41374-020-00515-z
Inside the USCAP Journals
- Laboratory Investigation, Published online: 23 December 2020; doi:10.1038/s41374-020-00521-1
  Inside the USCAP JournalsLaboratory Investigation, Published online: 2020-12-23; doi:10.1038/s41374-020-00521-12020-12-23
  DOI: 10.1038/s41374-020-00521-1
GTSE1 promotes prostate cancer cell proliferation via the SP1/FOXM1
signaling pathway
- Laboratory Investigation, Published online: 16 December 2020; doi:10.1038/s41374-020-00510-4
  This study confirms that the expression of GTSE1 in prostate cancer is significantly increased and negatively correlated with patient prognosis. Furthermore, GTSE1 promotes prostate cancer cell proliferation via the SP1/FOXM1 signaling pathway, which facilitates tumorigenesis and progression. These results suggest that GTSE1 has potential value as a prognostic marker and therapeutic target in prostate cancer.Laboratory Investigation, Published online: 2020-12-16; doi:10.1038/s41374-020-00510-42020-12-16
  DOI: 10.1038/s41374-020-00510-4
LncRNA SNHG5 upregulation induced by YY1 contributes to angiogenesis via
miR-26b/CTGF/VEGFA axis in acute myelogenous leukemia
- Laboratory Investigation, Published online: 14 December 2020; doi:10.1038/s41374-020-00519-9
  This study reveals that upregulation of lncRNA small nucleolar RNA host gene 5 (SNHG5), mediated by Yin Yang 1 (YY1), activates connective tissue growth factor (CTGF)/vascular endothelial growth factor (VEGFA) axis via targeting miR-26b to regulate angiogenesis of acute myelogenous leukemia (AML), providing new insights into mechanisms of AML.Laboratory Investigation, Published online: 2020-12-14; doi:10.1038/s41374-020-00519-92020-12-14
  DOI: 10.1038/s41374-020-00519-9

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