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UROLOGY, NEPHROLOGY AND ANDROLOGY (155 journals)                     

Showing 1 - 155 of 155 Journals sorted alphabetically
Acta Urológica Portuguesa     Open Access   (Followers: 1)
Actas Urológicas Españolas     Full-text available via subscription   (Followers: 3)
Actas Urológicas Españolas (English Edition)     Full-text available via subscription   (Followers: 1)
Advances in Chronic Kidney Disease     Full-text available via subscription   (Followers: 11)
Advances in Urology     Open Access   (Followers: 13)
African Journal of Nephrology     Open Access  
African Journal of Urology     Open Access   (Followers: 7)
AJP Renal Physiology     Hybrid Journal   (Followers: 8)
Aktuelle Urologie     Hybrid Journal   (Followers: 11)
American Journal of Kidney Diseases     Hybrid Journal   (Followers: 40)
American Journal of Men's Health     Open Access   (Followers: 9)
American Journal of Nephrology     Full-text available via subscription   (Followers: 35)
Andrologia     Hybrid Journal   (Followers: 2)
Andrology     Hybrid Journal   (Followers: 4)
Andrology & Gynecology : Current Research     Hybrid Journal   (Followers: 4)
Andrology and Genital Surgery     Open Access   (Followers: 7)
Andrology-Open Access     Open Access  
Annales d'Urologie     Full-text available via subscription  
Arab Journal of Nephrology and Transplantation     Open Access   (Followers: 1)
Arab Journal of Urology     Open Access   (Followers: 7)
Archives of Clinical Nephrology     Open Access   (Followers: 2)
Archivio Italiano di Urologia e Andrologia     Open Access   (Followers: 1)
Archivos Españoles de Urología     Open Access  
Asian Journal of Andrology     Open Access   (Followers: 1)
Asian Journal of Urology     Open Access   (Followers: 3)
Bangladesh Journal of Urology     Open Access   (Followers: 5)
BANTAO Journal     Open Access  
Basic and Clinical Andrology     Open Access  
BJU International     Hybrid Journal   (Followers: 35)
BMC Nephrology     Open Access   (Followers: 9)
BMC Urology     Open Access   (Followers: 15)
Canadian Journal of Kidney Health and Disease     Open Access   (Followers: 6)
Canadian Urological Association Journal     Open Access   (Followers: 2)
Cancer Urology     Open Access   (Followers: 2)
Cardiorenal Medicine     Full-text available via subscription   (Followers: 2)
Case Reports in Nephrology     Open Access   (Followers: 5)
Case Reports in Nephrology and Dialysis     Open Access   (Followers: 8)
Case Reports in Urology     Open Access   (Followers: 12)
Clinical and Experimental Nephrology     Hybrid Journal   (Followers: 4)
Clinical Journal of the American Society of Nephrology     Full-text available via subscription   (Followers: 19)
Clinical Medicine Insights : Urology     Open Access   (Followers: 3)
Clinical Nephrology     Full-text available via subscription   (Followers: 8)
Clinical Nephrology and Urology Science     Open Access   (Followers: 6)
Clinical Queries: Nephrology     Hybrid Journal   (Followers: 1)
Cuadernos de Cirugía     Open Access   (Followers: 3)
Current Opinion in Nephrology & Hypertension     Hybrid Journal   (Followers: 10)
Current Opinion in Urology     Hybrid Journal   (Followers: 12)
Current Urology     Open Access   (Followers: 10)
Current Urology Reports     Hybrid Journal   (Followers: 5)
Der Nephrologe     Hybrid Journal  
Der Urologe     Hybrid Journal   (Followers: 7)
EMC - Urología     Full-text available via subscription  
Enfermería Nefrológica     Open Access   (Followers: 1)
European Urology     Full-text available via subscription   (Followers: 39)
European Urology Focus     Hybrid Journal   (Followers: 6)
European Urology Supplements     Full-text available via subscription   (Followers: 15)
Forum Nefrologiczne     Full-text available via subscription  
Geriatric Nephrology and Urology     Hybrid Journal   (Followers: 7)
Giornale di Clinica Nefrologica e Dialisi     Open Access  
Herald Urology     Open Access   (Followers: 2)
Hong Kong Journal of Nephrology     Open Access   (Followers: 3)
Human Andrology     Partially Free   (Followers: 2)
IJU Case Reports     Open Access  
Indian Journal of Nephrology     Open Access   (Followers: 2)
Indian Journal of Urology     Open Access   (Followers: 5)
International Brazilian Journal of Urology     Open Access   (Followers: 5)
International Journal of Nephrology     Open Access   (Followers: 2)
International Journal of Nephrology and Renovascular Disease     Open Access   (Followers: 2)
International Journal of Urology     Hybrid Journal   (Followers: 12)
International Urology and Nephrology     Hybrid Journal   (Followers: 7)
Jornal Brasileiro de Nefrologia     Open Access  
Journal für Urologie und Urogynäkologie/Österreich     Hybrid Journal  
Journal of Clinical Nephrology     Open Access   (Followers: 1)
Journal of Clinical Urology     Hybrid Journal   (Followers: 14)
Journal of Endoluminal Endourology     Open Access  
Journal of Endourology     Hybrid Journal   (Followers: 2)
Journal of Endourology Case Reports     Hybrid Journal  
Journal of Genital System & Disorders     Hybrid Journal   (Followers: 3)
Journal of Integrative Nephrology and Andrology     Open Access   (Followers: 2)
Journal of Kidney Cancer and VHL     Open Access  
Journal of Lower Genital Tract Disease     Hybrid Journal  
Journal of Nephrology     Hybrid Journal   (Followers: 4)
Journal of Nephrology Research     Open Access   (Followers: 3)
Journal of Pediatric Nephrology     Open Access   (Followers: 3)
Journal of Renal Care     Hybrid Journal   (Followers: 8)
Journal of Renal Nursing     Full-text available via subscription   (Followers: 12)
Journal of Renal Nutrition     Hybrid Journal   (Followers: 29)
Journal of Renal Nutrition and Metabolism     Open Access   (Followers: 1)
Journal of the American Society of Nephrology     Full-text available via subscription   (Followers: 27)
Journal of The Egyptian Society of Nephrology and Transplantation     Open Access  
Journal of Translational Neurosciences     Open Access  
Journal of Urology     Full-text available via subscription   (Followers: 53)
Journal of Urology & Nephrology     Open Access   (Followers: 1)
Kidney Disease and Transplantation     Open Access   (Followers: 4)
Kidney Diseases     Open Access   (Followers: 3)
Kidney International     Hybrid Journal   (Followers: 44)
Kidney International Reports     Open Access   (Followers: 3)
Kidney Medicine     Open Access  
Kidney Research Journal     Open Access   (Followers: 6)
Kidneys (Počki)     Open Access   (Followers: 1)
Nature Reviews Nephrology     Full-text available via subscription   (Followers: 19)
Nature Reviews Urology     Full-text available via subscription   (Followers: 13)
Nefrología (English Edition)     Open Access  
Nefrología (Madrid)     Open Access  
Nephro-Urology Monthly     Open Access   (Followers: 1)
Nephrology     Hybrid Journal   (Followers: 12)
Nephrology Dialysis Transplantation     Hybrid Journal   (Followers: 25)
Nephron     Hybrid Journal   (Followers: 4)
Nephron Clinical Practice     Full-text available via subscription   (Followers: 4)
Nephron Experimental Nephrology     Full-text available via subscription   (Followers: 4)
Nephron Extra     Open Access   (Followers: 1)
Nephron Physiology     Full-text available via subscription   (Followers: 4)
Neurourology and Urodynamics     Hybrid Journal   (Followers: 1)
OA Nephrology     Open Access   (Followers: 2)
Open Access Journal of Urology     Open Access   (Followers: 6)
Open Journal of Nephrology     Open Access   (Followers: 5)
Open Journal of Urology     Open Access   (Followers: 7)
Open Urology & Nephrology Journal     Open Access  
Pediatric Urology Case Reports     Open Access   (Followers: 7)
Portuguese Journal of Nephrology & Hypertension     Open Access   (Followers: 1)
Progrès en Urologie     Full-text available via subscription  
Progrès en Urologie - FMC     Full-text available via subscription  
Prostate Cancer and Prostatic Diseases     Hybrid Journal   (Followers: 6)
Renal Failure     Open Access   (Followers: 12)
Renal Replacement Therapy     Open Access   (Followers: 4)
Research and Reports in Urology     Open Access   (Followers: 4)
Revista de Nefrología, Diálisis y Trasplante     Open Access   (Followers: 1)
Revista Mexicana de Urología     Open Access   (Followers: 1)
Revista Urologia Colombiana     Open Access  
Saudi Journal of Kidney Diseases and Transplantation     Open Access   (Followers: 2)
Scandinavian Journal of Urology     Hybrid Journal   (Followers: 8)
Seminars in Nephrology     Hybrid Journal   (Followers: 11)
The Prostate     Hybrid Journal   (Followers: 8)
Therapeutic Advances in Urology     Open Access   (Followers: 4)
Trends in Urology & Men's Health     Partially Free   (Followers: 1)
Ukrainian Journal of Nephrology and Dialysis     Open Access   (Followers: 1)
Uro-News     Hybrid Journal   (Followers: 2)
Urolithiasis     Hybrid Journal   (Followers: 2)
Urologia Internationalis     Full-text available via subscription   (Followers: 2)
Urologia Journal     Hybrid Journal  
Urologic Clinics of North America     Full-text available via subscription   (Followers: 4)
Urologic Nursing     Full-text available via subscription   (Followers: 4)
Urologic Radiology     Hybrid Journal  
Urological Science     Open Access  
Urologicheskie Vedomosti     Open Access  
Urologie in der Praxis     Hybrid Journal  
Urologie Scan     Hybrid Journal  
Urology     Hybrid Journal   (Followers: 34)
Urology Annals     Open Access   (Followers: 4)
Urology Case Reports     Open Access   (Followers: 3)
Urology Practice     Full-text available via subscription   (Followers: 2)
Urology Times     Free   (Followers: 3)
Urology Video Journal     Open Access   (Followers: 1)
World Journal of Nephrology and Urology     Open Access   (Followers: 15)
World Journal of Urology     Hybrid Journal   (Followers: 12)


Similar Journals
Journal Cover
Kidney International
Journal Prestige (SJR): 3.238
Citation Impact (citeScore): 5
Number of Followers: 44  
  Hybrid Journal Hybrid journal (It can contain Open Access articles)
ISSN (Print) 0085-2538 - ISSN (Online) 1523-1755
Published by NPG Homepage  [138 journals]
  • Subscription Information
    • Citation: Kidney International 98, 3 (2020)
      PubDate: 2020-09
      DOI: 10.1016/S0085-2538(20)30842-5
      Issue No: Vol. 98, No. 3 (2020)
  • In This Issue
    • First page: 521
      Abstract: Sodium glucose cotransporter 2 (SGLT2) inhibitors attenuate adverse kidney outcomes in patients with type 2 diabetes. Although the mechanisms of protection are unknown, several possibilities have been suggested, including improved blood pressure, weight loss, glycemic control, and reduction of albuminuria. Li and colleagues conducted a mediation analysis using data from the CANagliflozin cardioVascular Assessment Study (CANVAS) to identify mechanisms of kidney protection afforded by canagliflozin.
      Citation: Kidney International 98, 3 (2020)
      PubDate: 2020-09
      DOI: 10.1016/j.kint.2020.07.004
      Issue No: Vol. 98, No. 3 (2020)
  • Cardiovascular complications of chronic kidney disease: pioneering studies
    • Authors: Tilman B. Drüeke; Jürgen Floege
      Pages: 522 - 526
      Abstract: Compared with the general population, patients with chronic kidney disease (CKD) suffer from a dramatic increase in cardiovascular morbidity and mortality. The incidence increases as CKD progresses. The relative increase is particularly marked in young as compared with elderly patients. Since its beginning, Kidney International has published numerous articles dealing with all aspects of this issue including diagnosis, pathophysiology, epidemiology, treatment, and prevention. The articles presented below have greatly contributed to a better understanding and management of cardiovascular disease in the setting of CKD.
      Citation: Kidney International 98, 3 (2020)
      PubDate: 2020-09
      DOI: 10.1016/j.kint.2020.07.001
      Issue No: Vol. 98, No. 3 (2020)
  • Disparities in end-stage kidney disease care for children: a global survey
    • Authors: Rowena Lalji; Anna Francis, Germaine Wong, Andrea K. Viecelli, Allison Tong, Armando Teixeira-Pinto, Mignon McCulloch, Aminu K. Bello, Adeera Levin, Meaghan Lunney, Mohamed A. Osman, Feng Ye, Vivekanand Jha, John Feehally, David C. Harris, David W. Johnson
      Pages: 527 - 532
      Abstract: Chronic kidney disease (CKD) affects approximately 11% to 13% of people worldwide and is associated with catastrophic economic expenditure.1 Although global variations in the burden of kidney disease, related care practices, and their health outcomes have been reported in adults,2 data describing the global capacity to deliver kidney replacement therapies (KRT), dialysis, and kidney transplantation) for children have never previously been described, to our knowledge. The present study reports current disparities in ESKD care between children and adults around the world, along with the barriers to achieving equity for children, based on the findings of the 2018 International Society of Nephrology Global Kidney Health Atlas (GKHA) survey.
      Citation: Kidney International 98, 3 (2020)
      PubDate: 2020-09
      DOI: 10.1016/j.kint.2020.04.058
      Issue No: Vol. 98, No. 3 (2020)
  • Journal Club
    • Pages: 533 - 535
      Abstract: Kawarazaki et al. (J Clin Invest. 2020;130:4152–4166.)
      Citation: Kidney International 98, 3 (2020)
      PubDate: 2020-09
      DOI: 10.1016/j.kint.2020.07.005
      Issue No: Vol. 98, No. 3 (2020)
  • Variability in the B cell–receptor repertoire across immune-mediated
    • Authors: Brad H. Rovin; Loren D. Erickson
      Pages: 536 - 538
      Abstract: B cells are a central component of the adaptive immune system and are critical for protection against pathogens. They provide this protection by directly binding to pathogens through the B- cell immunoglobulin receptor (BCR) protein expressed on the cell surface and by the secretion of antibodies that tag pathogens for attack by other immune cells. Fundamental to this important function is the expression of a unique BCR by each B cell, which generates a highly diverse BCR repertoire capable of responding to a wide range of pathogens.
      Citation: Kidney International 98, 3 (2020)
      PubDate: 2020-09
      DOI: 10.1016/j.kint.2020.04.029
      Issue No: Vol. 98, No. 3 (2020)
  • Schlöndorff and Lee revealed crosstalk between glomerular cells and a
           role of BAMBI in diabetic kidney disease
    • Authors: Masaomi Nangaku
      Pages: 539 - 541
      Abstract: The editorial team of Kidney International feels truly proud to publish Detlef Schlöndorff’s legacy work. This seminal paper with Lee and Schlöndorff as joint senior authors revealed the importance of crosstalks between different glomerular cell types in diabetic kidney disease. Furthermore, they showed that bone morphogenetic protein (BMP) and activin membrane–bound inhibitor, an endogenous modulator of transforming growth factor-β signaling, plays a cell type–specific role and may be a good target for intervention against diabetic kidney disease.
      Citation: Kidney International 98, 3 (2020)
      PubDate: 2020-09
      DOI: 10.1016/j.kint.2020.04.027
      Issue No: Vol. 98, No. 3 (2020)
  • IL-9: a novel pro-podocyte survival cytokine in FSGS
    • Authors: Qisheng Lin; Madhav C. Menon, John Cijiang He
      Pages: 541 - 543
      Abstract: Progressive focal segmental glomerulosclerosis, characterized by podocyte loss, is often refractory to treatment and leads to progressive proteinuric chronic kidney disease. Interleukin-9 (IL-9) is reported to play important roles in innate and adaptive immunity in extrarenal inflammatory diseases. By using an IL-9 knockout mouse model, Xiong et al. demonstrate IL-9 as a novel pro-podocyte survival cytokine in the adriamycin nephropathy model of focal segmental glomerulosclerosis. Sequential in vitro and in vivo data corroborate a direct protective role, rather than an immunologic role, for IL-9 on podocyte survival.
      Citation: Kidney International 98, 3 (2020)
      PubDate: 2020-09
      DOI: 10.1016/j.kint.2020.05.045
      Issue No: Vol. 98, No. 3 (2020)
  • A new channel for the control of renin secretion in juxtaglomerular cells
    • Authors: Francois Alhenc-Gelas
      Pages: 543 - 545
      Abstract: The role of membrane channels in juxtaglomerular cell physiology is only partially understood. Pannexin 1 is a mechanosensitive, nonjunctional channel known for its role in adenosine triphosphate release. The study by DeLalio et al. documents involvement of pannexin 1 in renin secretion by studying mice deficient in pannexin 1 in renin-secreting cells and a prorenin-secreting cell line. Pannexin 1 is believed to suppress renin secretion and thereby modify blood pressure. The commentary addresses the broader physiological implication of these observations for the regulation of renin and blood pressure.
      Citation: Kidney International 98, 3 (2020)
      PubDate: 2020-09
      DOI: 10.1016/j.kint.2020.05.031
      Issue No: Vol. 98, No. 3 (2020)
  • Your blood pressure might be normal, but what about your podocytes'
    • Authors: John F. Bertram
      Pages: 545 - 547
      Abstract: Associations among hypertension, podocyte depletion, and chronic kidney disease are well-established, but whether mean arterial pressure (MAP) in the normal range influences podocyte depletion has not been previously examined. In this issue, Naik et al. use non-invasive urinary mRNA analysis to demonstrate that higher podocyte stress and detachment are associated with higher MAP in the normal range. The relationship between blood pressure and podocyte health suddenly got much more interesting.
      Citation: Kidney International 98, 3 (2020)
      PubDate: 2020-09
      DOI: 10.1016/j.kint.2020.05.020
      Issue No: Vol. 98, No. 3 (2020)
  • Blood pressure and kidney disease: chicken or egg (or both)'
    • Authors: Natalie Staplin; Richard Haynes, William G. Herrington
      Pages: 547 - 549
      Abstract: A recent study supports the concept that reduced kidney function causes higher blood pressure, but it found no evidence of causality in the opposite direction. We describe the method of bidirectional Mendelian randomization that was used to explore the direction of the causal relationship between kidney function and blood pressure, and examine the assumptions required for these analyses to give valid results.
      Citation: Kidney International 98, 3 (2020)
      PubDate: 2020-09
      DOI: 10.1016/j.kint.2020.05.048
      Issue No: Vol. 98, No. 3 (2020)
  • Autosomal dominant tubulointerstitial kidney disease: a new tool to guide
           genetic testing
    • Authors: Kaice A. LaFavers; Tarek M. El-Achkar
      Pages: 549 - 552
      Abstract: Autosomal dominant tubulointerstitial disease (ADTKD) is a dominantly inherited progressive nonglomerular disease. Several factors, such as a nonspecific clinical presentation and relative rarity, impede the phenotyping of ADTKD into clinically relevant subtypes and impair the appropriate implementation of genetic testing. The study by Olinger et al. describes the largest multicenter ADTKD cohort, which is likely to become a key resource. The authors also provide a new clinical tool that could guide diagnosis and genetic testing.
      Citation: Kidney International 98, 3 (2020)
      PubDate: 2020-09
      DOI: 10.1016/j.kint.2020.05.046
      Issue No: Vol. 98, No. 3 (2020)
  • Spot urine versus 24-hour urine collection for estimation of the
           generation of uremic toxins originating from gut microbial metabolism
    • Authors: Pieter Evenepoel; Henriette de Loor, H.S. Jorgensen, Bjorn Meijers
      Pages: 782 - 784
      Abstract: Uremic toxins originate, to a significant extent, from gut microbial metabolism. Important representatives include p-cresyl sulfate (PCS) and indoxyl sulfate.1 It remains a matter of controversy whether chronic kidney disease affects gut microbiome composition and metabolism, thereby altering the generation of toxins.2–4 Gryp et al. argued against this, partly based on the analysis of spot urine samples in 141 patients with chronic kidney disease.2 We studied whether spot urine is a reasonable alternative to a 24-hour urine collection, considered to be the gold standard for the assessment of the 24-hour intestinal toxin generation rate.
      Citation: Kidney International 98, 3 (2020)
      PubDate: 2020-09
      DOI: 10.1016/j.kint.2020.05.016
      Issue No: Vol. 98, No. 3 (2020)
  • The authors reply
    • Authors: Tessa Gryp; Raymond Vanholder, Griet Glorieux
      First page: 784
      Abstract: Referring to Gryp et al.,1 Evenepoel et al. discourage using spot urine uremic toxin/creatinine ratios (Uspot/C) as a proxy of uremic toxin generation,1 because of poor agreement between Uspot/C and 24-hour urine excretion (U24h),2 confirming similar observations for 24-hour proteinuria.3 The question is whether the problem raised is specific for Uspot/C.
      Citation: Kidney International 98, 3 (2020)
      PubDate: 2020-09
      DOI: 10.1016/j.kint.2020.05.019
      Issue No: Vol. 98, No. 3 (2020)
  • Hyperkalemia in pseudohypoaldosteronism type 2 can be from mutated WNK4,
           but more often from impaired ubiquitination of normal WNK4
    • Authors: John K. Healy
      Pages: 784 - 785
      Abstract: Clase et al.1 provide 2 references showing that in pseudohypoaldosteronism type 2 (PHA2), hyperkalemia occurs because of increased NaCl reabsorption by the NaCl cotransporter in the distal tubule, leading to K+ retention. These references show that a mutant form of a WNK lysine-deficient protein kinase 4, known as WNK4, can induce the features of PHA2 in mice.
      Citation: Kidney International 98, 3 (2020)
      PubDate: 2020-09
      DOI: 10.1016/j.kint.2020.02.042
      Issue No: Vol. 98, No. 3 (2020)
  • The authors reply
    • Authors: David H. Ellison; Biff F. Palmer
      First page: 785
      Abstract: We appreciate Dr. Healy’s pointing out that pseudohypoaldosteronism type 2, which is a disease of hyperkalemic hypertension, most often results from mutations in CUL3 and KLHL3; in these cases, mutations increase WNK4 abundance because they impair WNK4 degradation.1 He suggests 3 possible mechanisms by which WNK4 excess may impair potassium excretion, one of which involves WNK4 acting as a “strong suppressant” of the potassium channel (renal outer medullary potassium channel [ROMK]). Some WNK4 overexpression mouse models do exhibit low ROMK activity,2 and Shibata et al.
      Citation: Kidney International 98, 3 (2020)
      PubDate: 2020-09
      DOI: 10.1016/j.kint.2020.05.018
      Issue No: Vol. 98, No. 3 (2020)
  • Chronic interstitial nephritis of agricultural communities: continuing
           with the term CKDu (chronic kidney disease of unknown cause) is
    • Authors: Chula Herath
      First page: 786
      Abstract: I read with interest the letter by Wimalawansa1 commenting on the article by Vervaet et al.2 and their response.3 Vervaet et al. reiterate that the main message of their article is the hard evidence of a toxic etiology to chronic interstitial nephritis of agricultural communities (CINAC)/chronic kidney disease of unknown cause (CKDu), although there has been no previous cellular evidence. Although Wimalawansa seems to concede that CINAC is likely a toxic nephropathy, his usage of the term “lysosomal vacuolation” clearly misinterprets the description of the CINAC lysosomal inclusions, which seem to be unique to some toxic nephropathies and not others.
      Citation: Kidney International 98, 3 (2020)
      PubDate: 2020-09
      DOI: 10.1016/j.kint.2020.05.014
      Issue No: Vol. 98, No. 3 (2020)
  • Selinexor-associated hyponatremia: single-center, real-world data
    • Authors: Jaya Kala; Omar Mamlouk, Kenar D. Jhaveri
      Pages: 789 - 791
      Abstract: Selinexor was approved by the US Food and Drug Administration for use in relapsed refractory multiple myeloma. In clinical trials evaluating the efficacy and safety of selinexor in the treatment of multiple myeloma, hyponatremia was reported, with an incidence ranging from 7% to 47%, that was asymptomatic, transient, and highly responsive to dose reduction and sodium supplementation.1–3 Of these patients, 19% were reported to have grade ≥3 hyponatremia (
      Citation: Kidney International 98, 3 (2020)
      PubDate: 2020-09
      DOI: 10.1016/j.kint.2020.06.007
      Issue No: Vol. 98, No. 3 (2020)
  • Soft-tissue infiltration in a peritoneal dialysis patient
    • Authors: Christian Maalouly; Mathilde Duesberg, Etienne Danse, Eric Goffin
      First page: 792
      Abstract: A 44-year-old woman on peritoneal dialysis for 4 months for end-stage kidney disease secondary to systemic lupus erythematosus resistant to glucocorticoid and immunosuppressive agents presented with a major painful mass in the right abdomen.
      Citation: Kidney International 98, 3 (2020)
      PubDate: 2020-09
      DOI: 10.1016/j.kint.2020.03.007
      Issue No: Vol. 98, No. 3 (2020)
  • Renal granulomatous arteritis induced by immune checkpoint inhibitors
    • Authors: Nana Ishimura; Yayoi Shiotsu, Naoko Masuzawa, Shinji Sawai, Yasuto Sunahara, Noriko Urata, Fuminao Kanehisa, Keiichi Tamagaki
      First page: 793
      Abstract: A 67-year-old woman received combined nivolumab and ipilimumab for metastatic melanoma. After 2 months of treatment, she developed fever, chills, and diarrhea. Although bacteriuria improved with antibiotics, fever continued. Her serum creatinine increased from 0.63 to 4.24 mg/dl over 9 days. Antineutrophil cytoplasmic antibodies were negative. Urinalysis demonstrated proteinuria of 1.47 g/gCr and persistent pyuria, but no hematuria.
      Citation: Kidney International 98, 3 (2020)
      PubDate: 2020-09
      DOI: 10.1016/j.kint.2020.03.008
      Issue No: Vol. 98, No. 3 (2020)
  • The Case A patient with recurrent ventricular fibrillation and renal
    • Authors: Maria López-Andreu; M. Dolores Navarro Cabello, Rafael Sánchez-Sánchez, J. Mariano Rodríguez-Portillo, Sagrario Soriano Cabrera
      Pages: 795 - 796
      Abstract: A 47-year-old man with a past medical history of renal stones in the last year was admitted to the intensive care unit with ventricular fibrillation requiring defibrillation and acute renal failure, with a serum creatinine level of 3.0 mg/d (estimated glomerular filtration rate 24.0 ml/min).
      Citation: Kidney International 98, 3 (2020)
      PubDate: 2020-09
      DOI: 10.1016/j.kint.2020.03.013
      Issue No: Vol. 98, No. 3 (2020)
  • The Case Hyponatremia with an increased osmolar gap
    • Authors: Ashish Verma; Ankit B. Patel, Gearoid M. McMahon
      Pages: 797 - 798
      Abstract: A 53-year-old woman with a history of chronic obstructive pulmonary disease, epilepsy, hypertension, and alcohol abuse presented after getting a burn injury on her lap from spilling boiled water. She reported 3 vodka drinks daily. Her medications included valproic acid, sertraline, isosorbide mononitrate, omeprazole, and loratadine. Her blood pressure was 133/84 mm Hg, and her pulse was 98/min. On physical examination she was drowsy but followed commands and had moist mucus membranes, jugular venous pressure of 6 cm of H2O, clear bilateral airway movement, and no pedal edema.
      Citation: Kidney International 98, 3 (2020)
      PubDate: 2020-09
      DOI: 10.1016/j.kint.2020.03.006
      Issue No: Vol. 98, No. 3 (2020)
  • The sodium/proton exchanger NHA2 regulates blood pressure through a
           WNK4-NCC dependent pathway in the kidney.
    • Authors: Manuel A. Anderegg; Giuseppe Albano, Daniela Hanke, Christine Deisl, Dominik E. Uehlinger, Simone Brandt, Rajesh Bhardwaj, Matthias A. Hediger, Daniel G. Fuster
      Abstract: NHA2 is a sodium/proton exchanger associated with arterial hypertension in humans, but the role of NHA2 in kidney function and blood pressure homeostasis is currently unknown. Here we show that NHA2 localizes almost exclusively to distal convoluted tubules in the kidney. NHA2 knock-out mice displayed reduced blood pressure, normocalcemic hypocalciuria and an attenuated response to the thiazide diuretic hydrochlorothiazide. Phosphorylation of the thiazide-sensitive sodium/chloride cotransporter NCC and its upstream activating kinase Ste20/SPS1-related proline/alanine rich kinase (SPAK), as well as the abundance of with no lysine kinase 4 (WNK4), were significantly reduced in the kidneys of NHA2 knock-out mice.
      Citation: Kidney International (2020)
      PubDate: 2020-09-18
      DOI: 10.1016/j.kint.2020.08.023
  • Immune evasion in renal cell carcinoma: biology, clinical translation,
           future directions
    • Authors: Xiaoyang Wang; Robert Lopez, Rebecca A. Luchtel, Sassan Hafizi, Benjamin Gartrell, Niraj Shenoy
      Abstract: Targeted therapies and immune checkpoint inhibitors have advanced the treatment landscape of Renal Cell Carcinoma (RCC) over the last decade. While checkpoint inhibitors have demonstrated survival benefit and are currently approved in the front-line and second-line settings, primary and secondary resistance is common. A comprehensive understanding of the mechanisms of immune evasion in RCC is therefore critical to the development of effective combination treatment strategies. This article reviews the current understanding of the different, yet coordinated, mechanisms adopted by RCC cells to evade immune killing; summarizes various aspects of clinical translation thus far, including the currently registered RCC clinical trials exploring agents in combination with checkpoint inhibitors; and provides perspectives on the current landscape and future directions for the field.
      Citation: Kidney International (2020)
      PubDate: 2020-09-16
      DOI: 10.1016/j.kint.2020.08.028
  • Successful Simultaneous Pancreas and Kidney Transplant in a Patient
           Post-COVID-19 Infection
    • Authors: Neeraj Singh; Srijan Tandukar, Gazi Zibari, Muhammad Saad Naseer, Hosein S. Amiri, Millie Samaniego
      Abstract: The Coronavirus Disease-2019 (COVID-19) pandemic has slowed down the solid organ transplantation worldwide. Although, we have heard of few solid organ transplants having been performed in patients recovered from COVID-19 infection, none has been reported yet. We present a patient who underwent a simultaneous pancreas and kidney transplantation (SPK) after recovering from COVID-19 and is doing well close to 2 months post-transplantation. A 66-year-old Caucasian female with end-stage renal disease (ESRD) secondary to insulin dependent type 2 diabetes mellitus was called in to undergo SPK.
      Citation: Kidney International (2020)
      PubDate: 2020-09-15
      DOI: 10.1016/j.kint.2020.09.004
  • Plasma cadmium is associated with increased risk of long-term kidney graft
    • Authors: Camilo G. Sotomayor; Dion Groothof, Joppe J. Vodegel, Michele F. Eisenga, Tim J. Knobbe, Jan IJmker, Rosa G.M. Lammerts, Martin H. de Borst, Stefan P. Berger, Ilja M. Nolte, Ramón Rodrigo, Riemer H.J.A. Slart, Gerjan J. Navis, Daan J. Touw, Stephan J.L. Bakker
      Abstract: The kidney is one of the most sensitive organs to cadmium-induced toxicity, particularly in conditions of long-term oxidative stress. We hypothesized that, in kidney transplant recipients, nephrotoxic exposure to cadmium represents an overlooked hazard for optimal graft function. To test this, we performed a prospective cohort study and included 672 outpatient kidney transplant recipients with a functioning graft of beyond one year. The median plasma cadmium was 58 ng/L. During a median 4.9 years of follow-up, 78 kidney transplant recipients developed graft failure with a significantly different distribution across tertiles of plasma cadmium (13, 26, and 39 events, respectively).
      Citation: Kidney International (2020)
      PubDate: 2020-09-13
      DOI: 10.1016/j.kint.2020.08.027
  • Subgroup analysis of the ASPirin in Reducing Events in the Elderly
           randomized clinical trial suggest aspirin did not improve outcomes in
           older adults with chronic kidney disease.
    • Authors: Rory Wolfe; James B. Wetmore, Robyn L. Woods, John J. McNeil, Hugh Gallagher, Paul Roderick, Rowan Walker, Mark R. Nelson, Christopher M. Reid, Raj C. Shah, Michael E. Ernst, Jessica E. Lockery, Andrew M. Tonkin, Walter P. Abhayaratna, Peter Gibbs, Erica M. Wood, Suzanne E. Mahady, Jeff D. Williamson, Geoffrey A. Donnan, Geoffrey C. Cloud, Anne M. Murray, Kevan R. Polkinghorne, ASPREE Investigator Group
      Abstract: The role of aspirin for primary prevention in older adults with chronic kidney disease (CKD) is unclear. Therefore, post hoc analysis of the randomized controlled trial ASPirin in Reducing Events in the Elderly (ASPREE) was undertaken comparing 100 mg of enteric-coated aspirin daily against matching placebo. Participants were community dwelling adults aged 70 years and older in Australia, 65 years and older in the United States, all free of a history of dementia or cardiovascular disease and of any disease expected to lead to death within five years.
      Citation: Kidney International (2020)
      PubDate: 2020-09-10
      DOI: 10.1016/j.kint.2020.08.011
  • Mineral bone disease in autosomal dominant polycystic kidney disease.
    • Authors: Berenice Gitomer; Renata Pereira, Isidro B. Salusky, Jason W. Stoneback, Tamara Isakova, Xuan Cai, Lorien S. Dalrymple, Norma Ofsthun, Zhiying You, Harmut H. Malluche, Franklin Maddux, Diana George, Vicente Torres, Arlene Chapman, Theodore I. Steinman, Myles Wolf, Michel Chonchol
      Abstract: Mice with disruption of Pkd1 in osteoblasts demonstrate reduced bone mineral density, trabecular bone volume and cortical thickness. To date, the bone phenotype in adult patients with autosomal dominant polycystic kidney disease (ADPKD) with stage I and II chronic kidney disease has not been investigated. To examine this, we characterized biochemical markers of mineral metabolism, examined bone turnover and biology, and estimated risk of fracture in patients with ADPKD. Markers of mineral metabolism were measured in 944 patients with ADPKD and other causes of kidney disease.
      Citation: Kidney International (2020)
      PubDate: 2020-09-10
      DOI: 10.1016/j.kint.2020.07.041
  • Sepsis-Associated Acute Kidney Injury: Is COVID-19 different'
    • Authors: John A. Kellum; Mitra K. Nadim, Lui G. Forni
      Abstract: Faced with a new disease, clinicians understandably resort to what they know. For example, we know severe viral pneumonia secondary to influenza, so when we began seeing COVID-19, our first impression was that it was a similar disease, so we felt we knew how to manage it. However, it soon became clear that COVID-19 was strikingly different. First, there was the high transmission rate including spread within hospitals and health care workers 1—but this could simply have been due to a new disease in a naïve population.
      Citation: Kidney International (2020)
      PubDate: 2020-09-09
      DOI: 10.1016/j.kint.2020.08.009
  • Human kidney organoids produce functional renin
    • Authors: Anusha S. Shankar; Zhaoyu Du, Hector Tejeda Mora, Thierry P.P. van den Bosch, Sander S. Korevaar, Ingrid M. Van den Berg – Garrelds, Eric Bindels, Carmen Lopez-Iglesias, Marian Clahsen-van Groningen, Joost Gribnau, Carla C. Baan, A.H. Jan Danser, Ewout J. Hoorn, Martin J. Hoogduijn
      Abstract: Renin production by the kidney is of vital importance for salt, volume, and blood pressure homeostasis. The lack of human models hampers investigation into the regulation of renin and its relevance for kidney physiology. To develop such a model, we used human induced pluripotent stem cell derived kidney organoids to study the role of renin and the renin-angiotensin system in the kidney. Extensive characterization of the kidney organoids revealed kidney-specific cell populations consisting of podocytes, proximal and distal tubular cells, stromal cells and endothelial cells.
      Citation: Kidney International (2020)
      PubDate: 2020-09-09
      DOI: 10.1016/j.kint.2020.08.008
  • Cystinuria: clinical practice recommendation
    • Authors: Aude Servais; Kay Thomas, Luca Dello Strologo, John A. Sayer, Soumeya Bekri, Aurelia Bertholet-Thomas, Matthew Bultitude, Giovanna Capolongo, Rimante Cerkauskiene, Michel Daudon, Steeve Doizi, Valentine Gillion, Silvia Gràcia-Garcia, Jan Halbritter, Laurence Heidet, Marleen van den Heijkant, Sandrine Lemoine, Bertrand Knebelmann, Francesco Emma, Elena Levtchenko, Metabolic Nephropathy Workgroup of the European Reference Network for Rare Kidney Diseases (ERKNet) eUROGEN
      Abstract: Cystinuria (OMIM 220100) is an autosomal recessive hereditary disorder in which high urinary cystine excretion leads to formation of cystine stones due to its low solubility at normal urinary pH. We developed clinical practice recommendation for diagnosis, surgical and medical treatment, and follow up of cystinuria patients. Elaboration of these Clinical Practice Recommendations spanned from June 2018 until December 2019 with a consensus conference in January 2019. Selected topic areas were chosen by the co-chairs of the conference.
      Citation: Kidney International (2020)
      PubDate: 2020-09-09
      DOI: 10.1016/j.kint.2020.06.035
  • The phosphoinositide 3-kinase inhibitor alpelisib restores actin
           organization and improves proximal tubule dysfunction in vitro and in a
           mouse model of Lowe syndrome and Dent disease
    • Authors: Marine Berquez; Jonathan R. Gadsby, Beatrice Paola Festa, Richard Butler, Stephen P. Jackson, Valeria Berno, Alessandro Luciani, Olivier Devuyst, Jennifer L. Gallop
      Abstract: Loss-of-function mutations in the OCRL gene, which encodes the phosphatidylinositol [PI] 4,5-bisphosphate [PI(4,5)P2] 5-phosphatase OCRL, cause defective endocytosis and proximal tubule dysfunction in Lowe syndrome and Dent disease 2. The defect is due to increased levels of PI(4,5)P2 and aberrant actin polymerization, blocking endosomal trafficking. PI 3-phosphate [PI(3)P] has been recently identified as a coactivator with PI(4,5)P2 in the actin pathway. Here, we tested the hypothesis that phosphoinositide 3-kinase (PI3K) inhibitors may rescue the endocytic defect imparted by OCRL loss, by rebalancing phosphoinositide signals to the actin machinery.
      Citation: Kidney International (2020)
      PubDate: 2020-09-09
      DOI: 10.1016/j.kint.2020.05.040
  • Proximal tubular dysfunction in patients with COVID-19: what have we
           learnt so far'
    • Authors: Fabian Braun; Tobias B. Huber, Victor G. Puelles
      Abstract: Recent studies have reported a variety of urine abnormalities in patients hospitalized due to SARS-CoV-2 infection. In a single center study from Belgium, Werion et al., now present a concise investigation of tubular dysfunction in COVID-19 patients identifying potential risk factors for increased disease severity. These data complement current evidence regarding SARS-CoV-2 presence and potential infection in the kidney.
      Citation: Kidney International (2020)
      PubDate: 2020-09-08
      DOI: 10.1016/j.kint.2020.09.002
  • Renin-angiotensin aldosterone inhibitor use at hospital discharge among
           patients with moderate to severe acute kidney injury and its association
           with recurrent acute kidney injury and mortality.
    • Authors: Edward D. Siew; Sharidan K. Parr, Khaled Abdel-Kader, Amy M. Perkins, Robert A. Greevy, Andrew J. Vincz, Jason Denton, Otis D. Wilson, Adriana M. Hung, T. Alp Ikizler, Cassianne Robinson-Cohen, Michael E. Matheny
      Abstract: Recurrent episodes of acute kidney injury (AKI) are common among AKI survivors. Renin-angiotensin aldosterone inhibitors (RAASi) are often indicated for these patients but may increase the risk for recurrent AKI. Here, we examined whether RAASi associates with a higher risk for recurrent AKI and mortality among survivors of moderate to severe AKI in a retrospective cohort of Veterans who survived Stage II or III AKI. The primary exposure was RAASi at hospital discharge and the primary endpoint was recurrent AKI within 12 months.
      Citation: Kidney International (2020)
      PubDate: 2020-09-08
      DOI: 10.1016/j.kint.2020.08.022
  • Magnetic resonance imaging accurately tracks kidney pathology and
           heterogeneity in the transition from acute kidney injury to chronic kidney
    • Authors: Jennifer R. Charlton; Yanzhe Xu, Teresa Wu, Kim A. deRonde, Jillian L. Hughes, Shourik Dutta, Gavin T. Oxley, Aleksandra Cwiek, Helen P. Cathro, Nathan P. Charlton, Mark R. Conaway, Edwin J. Baldelomar, Neda Parvin, Kevin M. Bennett
      Abstract: Acute kidney injury is common in hospitalized patients. Many of the patients who experience AKI develop chronic kidney disease. However, using clinically available tools it is difficult to predict who and when CKD will develop. CFE-MRI provides several measurements of functional glomeruli in preclinical studies. CFE-MRI has the potential to be translated to use in humans, to detect changes in the kidney following acute kidney injury and predict which patients may develop CKD. The next steps toward translation will include in vivo tracking of glomerular fate in preclinical models of AKI to CKD and assessing the toxicity of CF in repeated doses.
      Citation: Kidney International (2020)
      PubDate: 2020-09-08
      DOI: 10.1016/j.kint.2020.08.021
  • Prediction modelling - Part 2 - Using machine learning strategies to
           improve transplantation outcomes
    • Authors: Craig Peter Coorey; Ankit Sharma, Samuel Mueller, Jean Yang
      Abstract: Kidney transplant recipients and transplant physicians face important clinical questions where machine learning methods may help improve the decision-making process. This mini-review explores potential applications of machine learning methods to key stages of a kidney transplant recipient’s journey, from initial waitlisting and donor selection, to personalization of immunosuppression and prediction of post-transplantation events. Both unsupervised and supervised machine learning methods are presented, including k-means clustering, principal components analysis, k-nearest neighbors and random forests.
      Citation: Kidney International (2020)
      PubDate: 2020-09-07
      DOI: 10.1016/j.kint.2020.08.026
  • A cross sectional study of 502 patients found a diffuse hyperechoic kidney
           medulla pattern in patients with severe gout.
    • Authors: Thomas Bardin; Quang D. Nguyen, Khoy M. Tran, Nghia H. Le, Minh D. Do, Pascal Richette, Emmanuel Letavernier, Jean-Michel Correas, Mathieu Resche-Rigon
      Abstract: We have previously shown that ultrasonography can detect hyperechogenic crystal deposits in the kidney medulla of patients with gout. In this cross-sectional study we investigated the frequency and clinical correlates of hyperechogenic kidney medulla in 502 consecutive primary consultants for gout (ACR/EULAR criteria) at the Vien Gut medical center in Ho Chi Minh City, Vietnam. None of these patients received urate-lowering drugs. Kidney medulla echogenicity on B-mode ultrasonography was compared to that of the kidney cortex.
      Citation: Kidney International (2020)
      PubDate: 2020-09-05
      DOI: 10.1016/j.kint.2020.08.024
  • Preoperative Carfilzomib and Lulizumab based desensitization prolongs
           graft survival in a sensitized non-human primate model.
    • Authors: Paul M. Schroder; Robin Schmitz, Zachary W. Fitch, Brian Ezekian, Janghoon Yoon, Ashley Y. Choi, Miriam Manook, Andrew Barbas, Frank Leopardi, Mingqing Song, Alton B. Farris, Bradley Collins, Jean Kwun, Stuart J. Knechtle
      Abstract: Sensitized patients are difficult to transplant due to pre-formed anti-donor immunity. We have previously reported successful desensitization using carfilzomib and belatacept in a non-human primate (NHP) model. Here we evaluated selective blockade of the co-stimulatory signal (CD28-B7) with Lulizumab, which preserves the co-inhibitory signal (CTLA4-B7). Five maximally MHC-mismatched pairs of NHPs were sensitized to each other with two sequential skin transplants. Individuals from each pair were randomized to either desensitization with once-weekly Carfilzomib (27mg/m2 IV) and Lulizumab (12.5mg/kg SC) over four weeks, or no desensitization (Control).
      Citation: Kidney International (2020)
      PubDate: 2020-09-05
      DOI: 10.1016/j.kint.2020.08.020
  • Multifactorial intervention has a significant effect on diabetic kidney
           disease in patients with type 2 diabetes.
    • Authors: Kohjiro Ueki; Takayoshi Sasako, Yukiko Okazaki, Kana Miyake, Masaomi Nangaku, Yasuo Ohashi, Mitsuhiko Noda, Takashi Kadowaki, J-DOIT3 Study Group
      Abstract: To evaluate the effect of multifactorial intervention on the onset and progression of diabetic kidney disease in the patients with type 2 diabetes, we analyzed the effects of intensified multifactorial intervention (intensive therapy treatment targets; HbA1c under 6.2%, blood pressure under 120/75 mmHg, low-density lipoprotein cholesterol under 80 mg/dL) comparing with step-wise intensification of medications and life-style modifications of guideline-based standard care (conventional therapy treatment targets: HbA1c under 6.9%, blood pressure under 130/80 mmHg, low-density lipoprotein cholesterol under 120 mg/dL) on diabetic kidney disease.
      Citation: Kidney International (2020)
      PubDate: 2020-09-03
      DOI: 10.1016/j.kint.2020.08.012
  • Time-dependent lymphocyte count after transplantation is associated with
           higher risk of graft failure and death.
    • Authors: Amaury Dujardin; Marine Lorent, Yohann Foucher, Christophe Legendre, Clarisse Kerleau, Sophie Brouard, Magali Giral, DIVAT consortium
      Abstract: The transplantation field requires the identification of specific risk factors associated with the level of immunosuppression. Here, our aim was to analyze the association between the number of circulating lymphocytes, monitored routinely by complete blood cell counts during outpatient visits, and patient and graft survival. In total, 2,999 kidney or combined kidney-pancreas recipients transplanted between 2000 and 2016, from two University hospitals, were enrolled. We investigated the etiological relationship between time-dependent lymphocyte count beyond one year after transplantation and patient and graft survival, viral infection and cancer risk using time-dependent multivariate Cox models.
      Citation: Kidney International (2020)
      PubDate: 2020-09-03
      DOI: 10.1016/j.kint.2020.08.010
  • Development and testing of an artificial intelligence tool for predicting
           end stage kidney disease in patients with immunoglobulin A nephropathy.
    • Authors: Francesco Paolo Schena; Vito Walter Anelli, Joseph Trotta, Tommaso Di Noia, Carlo Manno, Giovanni Tripepi, Graziella D’Arrigo, Nicholas C. Chesnaye, Maria Luisa Russo, Maria Stangou, Aikaterini Papagianni, Carmine Zoccali, Vladimir Tesar, Rosanna Coppo
      Abstract: We have developed an artificial neural network prediction model for end-stage kidney disease (ESKD) in patients with primary immunoglobulin A nephropathy (IgAN) using a retrospective cohort of 948 patients with IgAN. Our tool is based on a two-step procedure of a classifier model that predicts ESRD, and a regression model that predicts development of ESKD over time. The classifier model showed a performance value of 0.82 (area under the receiver operating characteristic curve) in patients with a follow-up of five years, which improved to 0.89 at the ten-year follow-up.
      Citation: Kidney International (2020)
      PubDate: 2020-09-01
      DOI: 10.1016/j.kint.2020.07.046
  • HLA-D and PLA2R1 risk alleles associate with recurrent primary membranous
           nephropathy in kidney transplant recipients.
    • Authors: Lena Berchtold; Eric Letouzé, Mariam Priya Alexander, Guillaume Canaud, Anne-Els van de Logt, Patrick Hamilton, Christiane Mousson, Vincent Vuiblet, Ann M. Moyer, Sylvain Guibert, Petra Mrázová, Charlène Levi, Valérie Dubois, Josep Maria Cruzado, Armando Torres, Manish J. Gandhi, Nadhir Yousfi, Vladimir Tesar, Ondrej Viklický, Maryvonne Hourmant, Bruno Moulin, Philippe Rieu, Gabriel Choukroun, Christophe Legendre, Jack Wetzels, Paul Brenchley, José Aurelio Ballarín Castan, Hanna Debiec, Pierre Ronco
      Abstract: Recurrence of primary membranous nephropathy after transplantation occurs in up to 44% of patients and is driven by PLA2R antibody. Here, we asked whether genetic determinants could improve risk prediction. First, we sequenced PLA2R1 and HLA-D loci in 248 patients with primary membranous nephropathy and identified two independent single nucleotide polymorphisms (SNPs) at risk for primary membranous nephropathy at each locus. These were rs9271188 (intergenic between HLA-DRB1 and HLA-DQA1,) and rs9275086 (intergenic between HLA-DQB1 and HLA-DQA2) at the HLA-D locus along with rs6726925 and rs13018963 at the PLA2R1 locus.
      Citation: Kidney International (2020)
      PubDate: 2020-09-01
      DOI: 10.1016/j.kint.2020.08.007
  • Impaired angiotensin II type 1 receptor signaling contributes to sepsis
           induced acute kidney injury.
    • Authors: Daniel E. Leisman; Tiago D. Fernandes, Vanesa Bijol, Mabel N. Abraham, Jake R. Lehman, Matthew D. Taylor, Christine Capone, Omar Yaipan, Rinaldo Bellomo, Clifford S. Deutschman
      Abstract: In sepsis-induced acute kidney injury, kidney blood flow may increase despite decreased glomerular filtration. Normally, angiotensin-II reduces kidney blood flow to maintain filtration. We hypothesized that sepsis reduces angiotensin type-1 receptor (AT1R) expression to account for this observation and tested this hypothesis in a patient case-control study and studies in mice. Seventy-three mice underwent cecal ligation and puncture (a sepsis model) or sham operation. Additionally, 94 septic mice received losartan (selective AT1R antagonist), angiotensin II without or with losartan, or vehicle.
      Citation: Kidney International (2020)
      PubDate: 2020-08-31
      DOI: 10.1016/j.kint.2020.07.047
  • Management of idiopathic childhood nephrotic syndrome in Sub-Saharan
           Africa: Ibadan consensus statement
    • Authors: Christopher Esezobor; Adebowale D. Ademola, Adewale E. Adetunji, Emmanuel Ademola Anigilaje, Anthony Batte, Fatima Nma Jiya Bello, Francis Fredrick Furia, Uzoamaka Muoneke, Mignon McCulloch, Peter Nourse, Patience Obiagwu, Odutola Odetunde, Perditer Okyere, Adaobi Solarin, Elliot Koranteng Tannor, Damien Noone, Rasheed Gbadegesin, Rulan S. Parekh, H3 Africa Kidney Disease Research Network
      Abstract: In sub-Saharan Africa, glomerular disease, specifically nephrotic syndrome (NS), is the leading cause of chronic kidney disease (CKD) and end-stage kidney disease (ESKD) in children.1-3 Prevalence of NS is estimated at 2-7 per 100,000 children worldwide,1 and it is one of the more common causes of pediatric kidney disorders in Africa. Despite limited reports from Nigeria and Sudan, 2-4 the overall incidence of NS in Africa is unknown. Among the 54 African countries, only 17 have information on the burden of childhood NS indicating substantial underreporting.
      Citation: Kidney International (2020)
      PubDate: 2020-08-28
      DOI: 10.1016/j.kint.2020.07.045
  • Consensus Definitions for Glomerular Lesions by Light and Electron
           Microscopy: Recommendations from a Working Group of the Renal Pathology
    • Authors: Mark Haas; Surya V. Seshan, Laura Barisoni, Kerstin Amann, Ingeborg M. Bajema, Jan Ulrich Becker, Kensuke Joh, Danica Ljubanovic, Ian S.D. Roberts, Joris J. Roelofs, Sanjeev Sethi, Caihong Zeng, J. Charles Jennette
      Abstract: Over the past two decades, scoring systems for multiple glomerular diseases have emerged, as have consortia of pathologists and nephrologists for the study of glomerular diseases, including correlation of pathologic findings with clinical features and outcomes. However, one important limitation faced by members of these consortia and other renal pathologists and nephrologists in both investigative work and routine practice remains a lack of uniformity and precision in clearly defining the morphologic lesions on which the scoring systems are based.
      Citation: Kidney International (2020)
      PubDate: 2020-08-28
      DOI: 10.1016/j.kint.2020.08.006
  • A non-biodegradable scaffold-free cell sheet of genome-engineered
           mesenchymal stem cells inhibits development of acute kidney injury.
    • Authors: Hye-Jeong Park; Min Jung Kong, Hyo-Ju Jang, Jeong-In Cho, Eui-Jung Park, In-Kyu Lee, Jørgen Frøkiær, Rikke Norregaard, Kwon Moo Park, Tae-Hwan Kwon
      Abstract: Cell therapy using genome-engineered stem cells has emerged as a novel strategy for the treatment of kidney diseases. By exploiting genome editing technology, human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) secreting an angiogenic factors or an anti-inflammatory factor were generated for therapeutic application in acute kidney injury. Junction polymerase chain reaction analysis verified Zinc Finger Nucleases-assisted integration of the desired gene into the hUC-MSCs. Flow cytometry and differentiation assays indicated that genome editing did not affect the differentiation potential of these mesenchymal stem cells.
      Citation: Kidney International (2020)
      PubDate: 2020-08-24
      DOI: 10.1016/j.kint.2020.07.043
  • Low incidence of SARS-CoV-2, risk factors of mortality and the course of
           illness in the French national cohort of dialysis patients.
    • Authors: Couchoud Cécile; Bayer Florian, Ayav Carole, Béchade Clémence, Brunet Philippe, Chantrel François, Frimat Luc, Galland Roula, Hourmant Maryvonne, Laurain Emmanuelle, Lobbedez Thierry, Mercadal Lucile, Moranne Olivier, in the name of the French REIN registry
      Abstract: The aim of this study was to estimate the incidence of COVID-19 disease in the French national population of dialysis patients, their course of illness and to identify the risk factors associated with mortality. Our study included all patients on dialysis recorded in the French REIN Registry in April 2020. Clinical characteristics at last follow-up and the evolution of COVID-19 illness severity over time were recorded for diagnosed cases (either suspicious clinical symptoms, characteristic signs on the chest scan or a positive reverse transcription polymerase chain reaction) for SARS-CoV-2.
      Citation: Kidney International (2020)
      PubDate: 2020-08-24
      DOI: 10.1016/j.kint.2020.07.042
  • An initial report from the French SOT COVID Registry suggests high
           mortality due to Covid-19 in recipients of kidney transplants.
    • Authors: Sophie Caillard; Dany Anglicheau, Marie Matignon, Antoine Durrbach, Clarisse Greze, Luc Frimat, Olivier Thaunat, Tristan Legris, Valerie Moal, Pierre Francois Westeel, Nassim Kamar, Philippe Gatault, Renaud Snanoudj, Antoine Sicard, Dominique Bertrand, Charlotte Colosio, Lionel Couzi, Jonathan M. Chemouny, Christophe Masset, Gilles Blancho, Jamal Bamoulid, Agnes Duveau, Nicolas Bouvier, Nathalie Chavarot, Philippe Grimbert, Bruno Moulin, Yannick Le Meur, Marc Hazzan, French SOT COVID Registry
      Abstract: Notwithstanding the ongoing coronavirus disease-2019 (Covid-19) pandemic, information on its clinical presentation and prognosis in recipients of a kidney transplant remain scanty. The aim of this registry-based observational study was to explore characteristics and clinical outcomes of recipients of kidney transplants included in the French nationwide Registry of Solid Organ Transplant Recipients with Covid-19. Covid-19 was diagnosed in symptomatic patients who had a positive PCR assay for SARS-CoV-2 or having typical lung lesions on imaging.
      Citation: Kidney International (2020)
      PubDate: 2020-08-23
      DOI: 10.1016/j.kint.2020.08.005
  • Development and evaluation of deep learning-based segmentation of
           histologic structures in the kidney cortex with multiple histologic
    • Authors: Catherine P. Jayapandian; Yijiang Chen, Andrew R. Janowczyk, Matthew B. Palmer, Clarissa A. Cassol, Miroslav Sekulic, Jeffrey B. Hodgin, Jarcy Zee, Stephen M. Hewitt, John O’Toole, Paula Toro, John R. Sedor, Laura Barisoni, Anant Madabhushi
      Abstract: The application of deep learning for automated segmentation (delineation of boundaries) of histologic primitives (structures) from whole slide images can facilitate the establishment of novel protocols for kidney biopsy assessment. Here, we developed and validated deep learning networks for the segmentation of histologic structures on kidney biopsies and nephrectomies. For development, we examined 125 biopsies for Minimal Change Disease collected across 29 NEPTUNE enrolling centers along with 459 whole slide images stained with Hematoxylin & Eosin (125), Periodic Acid Schiff (125), Silver (102), and Trichrome (107)] divided into training, validation and testing sets (ratio 6:1:3).
      Citation: Kidney International (2020)
      PubDate: 2020-08-21
      DOI: 10.1016/j.kint.2020.07.044
  • APOL1 variant associated kidney disease: From trypanosomes to podocyte
    • Authors: Etienne Pays
      Abstract: Expression of the C-terminal APOL1 variants G1 and G2 is strongly linked to chronic kidney disease. The recent analysis of podocytes genetically engineered to express either C-terminal truncated APOL1 or disrupted APOL3 allowed the conclusion that C-terminal APOL1 variants induce reorganization of actomyosin activities through inhibition of APOL3 functions. This editorial is not intended to review the literature in the field, but rather to discuss the proposal that podocyte dysfunctions linked to APOL3 inactivation can account for chronic kidney disease linked to expression of the APOL1 risk variants G1 and G2.
      Citation: Kidney International (2020)
      PubDate: 2020-08-21
      DOI: 10.1016/j.kint.2020.07.034
  • Automated total kidney volume measurements in pre-clinical magnetic
           resonance imaging for resourcing imaging data, annotations, and source
    • Authors: Marie E. Edwards; Sigapriya Periyanan, Deema Anaam, Adriana V. Gregory, Timothy L. Kline
      Abstract: The objective of this study was to validate a fully automated total kidney volume measurement method for pre-clinical rodent trials that is fast, accurate, reproducible, and to provide these resources to the research community. Rodent studies that involve imaging are crucial for monitoring treatment efficacy in diseases such as polycystic kidney disease. Previous studies utilize manual or semi-automated segmentations, which are time consuming and potentially biased. To develop our automated system, a total of 150 axial magnetic resonance images (MRI) from a variety of mouse models were manually segmented and used to train/validate an automated algorithm.
      Citation: Kidney International (2020)
      PubDate: 2020-08-20
      DOI: 10.1016/j.kint.2020.07.040
  • NELL1 is a target antigen in malignancy-associated membranous nephropathy
    • Authors: Tiffany Caza; Samar Hassen, Zeljko Dvanajscak, Michael Kuperman, Rick Edmondson, Christian Herzog, Aaron Storey, John Arthur, L. Nicholas Cossey, Shree Sharma, Daniel Kenan, Christopher Larsen
      Abstract: Patients with membranous nephropathy have an increased risk of malignancy compared to the general population, but the target antigen for malignancy-associated membranous nephropathy is unknown. To explore this, we utilized mass spectrometry for antigen discovery in malignancy-associated membranous nephropathy examining immune complexes eluted from frozen kidney biopsy tissue using protein G bead immunoglobulin capture. Antigen discovery was performed comparing cases of membranous nephropathy of unknown and known type.
      Citation: Kidney International (2020)
      PubDate: 2020-08-19
      DOI: 10.1016/j.kint.2020.07.039
  • Statins, obesity, and the microbiome: A potential mechanism for the
           pleiotropic effects of statin therapy
    • Authors: Martin Reichel; Felix Knauf
      Abstract: Statins are the most commonly prescribed oral agents for lipid-lowering therapy. The drugs have a proven survival benefit when used as primary or secondary cardiovascular disease prevention over a wide range of baseline low density lipoprotein cholesterol (LDL-C) levels. Statins competitively inhibit hydroxymethyl-glutaryl CoA reductase (HMG-CoA reductase), the rate-limiting step in cholesterol biosynthesis. However, the exact mechanism(s) of clinical benefit with statins are incompletely understood.
      Citation: Kidney International (2020)
      PubDate: 2020-08-18
      DOI: 10.1016/j.kint.2020.07.038
  • Kidney-intrinsic factors determine the severity of ischemia/reperfusion
           injury in a mouse model of delayed graft function
    • Authors: Longhui Qiu; Xingqiang Lai, Jiao-jing Wang, Xin Yi Yeap, Shulin Han, Feibo Zheng, Charlie Lin, Zhuoli Zhang, Daniele Procissi, Deyu Fang, Lin Li, Edward B. Thorp, Michael M. Abecassis, Yashpal S. Kanwar, Zheng J. Zhang
      Abstract: Delayed graft function due to transplant ischemia/reperfusion injury adversely affects up to 50% of deceased-donor kidney transplant recipients. However, key factors contributing to the severity of ischemia/reperfusion injury remain unclear. Here, using a clinically relevant mouse model of delayed graft function, we demonstrated that donor genetic background and kidney-intrinsic MyD88/Trif-dependent innate immunity were key determinants of delayed graft function. Functional deterioration of kidney grafts directly corresponded with the duration of cold ischemia time.
      Citation: Kidney International (2020)
      PubDate: 2020-08-18
      DOI: 10.1016/j.kint.2020.07.033
  • Immunotactoid glomerulopathy is a rare entity with monoclonal and
           polyclonal variants.
    • Authors: Samih H. Nasr; Satoru S. Kudose, Samar M. Said, Dominick Santoriello, Mary E. Fidler, Sean R. Williamson, Sibel Erdogan Damgard, Sanjeev Sethi, Nelson Leung, Vivette D. D’Agati, Glen S. Markowitz
      Abstract: Immunotactoid glomerulopathy (ITG) is a rare form of glomerulonephritis for which our understanding is limited to case reports and small case series. Herein we describe the clinical, pathologic, and outcome characteristics of 73 patients with ITG who typically presented with proteinuria, hematuria, and renal insufficiency. Hematologic disorders were present in 66% of patients, including lymphoma in 41% (mainly chronic lymphocytic leukemia/small lymphocytic lymphoma), monoclonal gammopathy in 20%, and multiple myeloma in 6%.
      Citation: Kidney International (2020)
      PubDate: 2020-08-17
      DOI: 10.1016/j.kint.2020.07.037
  • Genetic or Pharmacologic Nrf2 Activation Increases Proteinuria in Chronic
           Kidney Disease in Mice
    • Authors: Brittney M. Rush; Corry D. Bondi, Sean D. Stocker, Kacie M. Barry, Sarah A. Small, Jason Ong, Soma Jobbagy, Donna B. Stolz, Sheldon I. Bastacky, Dionysios V. Chartoumpekis, Thomas W. Kensler, Roderick J. Tan
      Abstract: The nuclear factor erythroid 2 related factor 2 (Nrf2) pathway upregulates key cellular defenses. Clinical trials are utilizing pharmacologic Nrf2 inducers such as bardoxolone methyl to treat chronic kidney disease, but Nrf2 activation has been linked to a paradoxical increase in; proteinuria. To understand this effect, we examined genetically engineered mice with elevatedNrf2 signaling due to reduced expression of the Nrf2 inhibitor, Kelch-like ECH-associated protein-1 (Keap1). These Keap1FA/FA mice lacked baseline proteinuria but exhibited increased; proteinuria in experimental models evoked by adriamycin, angiotensin II, or protein overload.
      Citation: Kidney International (2020)
      PubDate: 2020-08-17
      DOI: 10.1016/j.kint.2020.07.036
  • A practical guide to multiple imputation of missing data in nephrology
    • Authors: Katrina Blazek; Anita van Zwieten, Valeria Saglimbene, Armando Teixeira-Pinto
      Abstract: Health data are often plagued with missing values which can greatly reduce the sample size if only complete cases are considered for analysis. Furthermore, analyses which ignore the missing data have the potential to introduce bias in the parameter estimates. Multiple imputation techniques have been developed to recover the information that would otherwise be lost when excluding observations with missing data and to help minimise bias. However, the validity of analyses using imputed data relies on the imputation model having been correctly specified.
      Citation: Kidney International (2020)
      PubDate: 2020-08-17
      DOI: 10.1016/j.kint.2020.07.035
  • Outcomes of patients with end-stage kidney disease hospitalized with
    • Authors: Jia H. Ng; Jamie S. Hirsch, Rimda Wanchoo, Mala Sachdeva, Vipulbhai Sakhiya, Susana Hong, Kenar D. Jhaveri, Steven Fishbane, Northwell COVID-19 Research Consortium the Northwell Nephrology COVID-19 Research Consortium
      Abstract: Given the high risk of infection-related mortality, patients with end-stage kidney disease (ESKD) may be at increased risk with COVID-19. To assess this, we compared outcomes of patients with and without ESKD, hospitalized with COVID-19. This was a retrospective study of patients admitted with COVID-19 from 13 New York. hospitals from March 1, 2020, to April 27, 2020, and followed through May 27, 2020. We measured primary outcome (in-hospital death), and secondary outcomes (mechanical ventilation and length of stay), Of 10,482 patients with COVID-19, 419 had ESKD.
      Citation: Kidney International (2020)
      PubDate: 2020-08-15
      DOI: 10.1016/j.kint.2020.07.030
  • A systematic review and participant-level meta-analysis found little
    • Authors: Weng Kit Lye; Euan Paterson, Christopher C. Patterson, Alexander P. Maxwell, Riswana Banu Binte Mohammed Abdul, E Shyong Tai, Ching Yu Cheng, Takamasa Kayama, Hidetoshi Yamashita, Mark Sarnak, Michael Shlipak, Kunihiro Matsushita, Unal Mutlu, Mohammad A. Ikram, Caroline Klaver, Annette Kifley, Paul Mitchell, Chelsea Myers, Barbara E. Klein, Ronald Klein, Tien Y. Wong, Charumathi Sabanayagam, Gareth J. McKay
      Abstract: Previously, variation in retinal vascular caliber has been reported in association with chronic kidney disease (CKD) but findings remain inconsistent. To help clarify this we conducted individual participant data meta-analysis and aggregate data meta-analysis on summary estimates to evaluate cross-sectional associations between retinal vascular caliber and CKD. A systematic review was performed using Medline and EMBASE for articles published until October 2018. The aggregate analysis used a two-stage approach combining summary estimates from eleven studies (44,803 patients) while the individual participant analysis used a one-stage approach combining raw data from nine studies (33,222 patients).
      Citation: Kidney International (2020)
      PubDate: 2020-08-15
      DOI: 10.1016/j.kint.2020.06.033
  • SARS-CoV-2 Causes a Specific Dysfunction of the Kidney Proximal Tubule
    • Authors: Alexis Werion; Leila Belkhir, Marie Perrot, Gregory Schmit, Selda Aydin, Zhiyong Chen, Andrea Penaloza, Julien De Greef, Halil Yildiz, Lucie Pothen, Jean Cyr Yombi, Joseph Dewulf, Anais Scohy, Ludovic Gérard, Xavier Wittebole, Pierre-François Laterre, Sara E. Miller, Olivier Devuyst, Michel Jadoul, Johann Morelle, CUSL COVID-19 Research Group
      Abstract: Coronavirus disease 2019 (COVID-19) is commonly associated with kidney damage, and the angiotensin converting enzyme 2 (ACE2) receptor for SARS-CoV-2 is highly expressed in the proximal tubule cells. Whether patients with COVID-19 present specific manifestations of proximal tubule dysfunction remains unknown. To test this, we examined a cohort of 49 patients requiring hospitalization in a large academic hospital in Brussels, Belgium. There was evidence of proximal tubule dysfunction in a subset of patients with COVID-19, as attested by low-molecular-weight proteinuria (70-80%), neutral aminoaciduria (46%), and defective handling of uric acid (46%) or phosphate (19%).
      Citation: Kidney International (2020)
      PubDate: 2020-08-10
      DOI: 10.1016/j.kint.2020.07.019
  • Measuring Quality in Living Donation and Kidney Transplantation: Moving
           Beyond Survival Metrics
    • Authors: Greg A. Knoll; Marie-Chantal Fortin, Jagbir Gill, Jeremy M. Grimshaw, David P. Hartell, Priscilla Karnabi, Christina D. Parsons, Hans Vorster, S. Joseph Kim
      Abstract: One-year patient and allograft survival have improved dramatically since the first successful kidney transplant in 1954. At many programs, 1-year allograft survival now exceeds 95%. Short-term survival metrics, such as 1-year patient/graft survival, are commonly used as a gauge to determine the “quality” of a transplant program. While most patients and clinicians have some understanding of what quality means, it is not easily defined in the healthcare setting. In a landmark report, the Institute of Medicine (IOM) characterized high-quality health care as one that is safe, effective, patient-centered, timely, efficient and equitable (Table 1).
      Citation: Kidney International (2020)
      PubDate: 2020-08-09
      DOI: 10.1016/j.kint.2020.07.014
  • Results of an explorative clinical evaluation suggest immediate and
           persistent post-reperfusion metabolic paralysis drives kidney ischemia
           reperfusion injury.
    • Authors: Jan H. Lindeman; Leonie G. Wijermars, Sarantos Kostidis, Oleg A. Mayboroda, Amy C. Harms, Thomas Hankemeier, Jörgen Bierau, Karthick B. Sai Sankar Gupta, Martin Giera, Marlies E. Reinders, Melissa C. Zuiderwijk Bsc, Sylvia E. Le Dévédec, Alexander F. Schaapherder, Jaap A. Bakker
      Abstract: Delayed graft function is the manifestation of ischemia reperfusion injury in the context of kidney transplantation. While hundreds of interventions successfully reduce ischemia reperfusion injury in experimental models, all clinical interventions have failed. This explorative clinical evaluation examined possible metabolic origins of clinical ischemia reperfusion injury combining data from 18 pre- and post-reperfusion tissue biopsies with 36 sequential arteriovenous blood samplings over the graft in three study groups.
      Citation: Kidney International (2020)
      PubDate: 2020-08-08
      DOI: 10.1016/j.kint.2020.07.026
  • Trajectories of glomerular filtration rate and progression to end stage
           kidney disease after kidney transplantation.
    • Authors: Marc Raynaud; Olivier Aubert, Peter P. Reese, Yassine Bouatou, Maarten Naesens, Nassim Kamar, Élodie Bailly, Magali Giral, Marc Ladrière, Moglie Le Quintrec, Michel Delahousse, Ivana Juric, Nikolina Basic-Jukic, Gaurav Gupta, Enver Akalin, Chen-Shan Chin, Cécile Proust-Lima, Georg Böhmig, Rainer Oberbauer, Mark D. Stegall, Andrew J. Bentall, Stanley C. Jordan, Edmund Huang, Denis Glotz, Christophe Legendre, Robert A. Montgomery, Dorry L. Segev, Jean-Philippe Empana, Morgan E. Grams, Josef Coresh, Xavier Jouven, Carmen Lefaucheur, Alexandre Loupy
      Abstract: Although the gold standard of monitoring kidney transplant function relies on glomerular filtration rate (GFR), little is known about GFR trajectories after transplantation, their determinants, and their association with outcomes. To evaluate these parameters we examined kidney transplant recipients receiving care at 15 academic centers. Patients underwent prospective monitoring of estimated GFR (eGFR) measurements, with assessment of clinical, functional, histological and immunological parameters.
      Citation: Kidney International (2020)
      PubDate: 2020-08-08
      DOI: 10.1016/j.kint.2020.07.025
  • Secretion of the epithelial sodium channel chaperone PCSK9 from the
           cortical collecting duct links sodium retention with hypercholesterolemia
           in nephrotic syndrome.
    • Authors: Eduardo Molina-Jijon; Stéphanie Gambut, Camille Macé, Carmen Avila-Casado, Lionel C. Clement
      Abstract: The proprotein PCSK9 functions as a chaperone for the epithelial sodium channel in the cortical collecting duct (CCD), is highly expressed in the liver, and plays a significant role in the pathogenesis of hypercholesterolemia. Lower levels of PCSK9 expression also occur in the normal kidney and intestine. Here, we found increased PCSK9 expression in the CCD of biopsies of patients with primary glomerular disease and explored a possible relationship with hypercholesterolemia of nephrotic syndrome.
      Citation: Kidney International (2020)
      PubDate: 2020-08-01
      DOI: 10.1016/j.kint.2020.06.045
  • Treatment Impact on COVID-19 evolution in hemodialysis patients
    • Authors: Sylvain Chawki; Albert Buchard, Hamza Sakhi, Karim Dardim, Karim El Sakhawi, Mokhtar Chawki, Henri Boulanger, Tomek Kofman, Djamal Dahmane, Philippe Rieu, David Attaf, Salima Ahriz-Saksi, Frederic Besson, Remy Boula, Ali Hafi, Afshin Massoumi, Ali Zineddine Diddaoui, Luc Fromentin, Patrick Michaut, Rachida Nebbad, Jean-François Desassis, Laurence Nicolet, Abderrahmane Ghazali, Julie Sohier-Attias, Larbi Lamriben, Arezki Adem, Emmanuel Dupuis, Mohamad-Khair Rifard, Dominique Joly, Khalil El Karoui, Philippe Attias, HD-CovIDF Study group
      Abstract: We retrospectively studied 248 patients on maintenance hemodialysis (MHD) affected by COVID-19 (1) in 19 private and academic MHD centers of the Paris, France area.
      Citation: Kidney International (2020)
      PubDate: 2020-08-01
      DOI: 10.1016/j.kint.2020.07.010
  • Amniotic fluid peptides predict postnatal kidney survival in developmental
           kidney disease.
    • Authors: Julie Klein; Bénédicte Buffin-Meyer, Franck Boizard, Nabila Moussaoui, Ophélie Lescat, Benjamin Breuil, Camille Fedou, Guylène Feuillet, Audrey Casemayou, Eric Neau, An Hindryckx, Luc Decatte, Elena Levtchenko, Anke Raaijmakers, Christophe Vayssière, Valérie Goua, Charlotte Lucas, Franck Perrotin, Sylvie Cloarec, Alexandra Benachi, Marie-Christine Manca-Pellissier, Hélène Laurichesse Delmas, Lucie Bessenay, Claudine Le Vaillant, Emma Allain-Launay, Jean Gondry, Bernard Boudailliez, Elisabeth Simon, Fabienne Prieur, Marie-Pierre Lavocat, Anne-Hélène Saliou, Loic De Parscau, Laurent Bidat, Catherine Noel, Corinne Floch, Guylène Bourdat-Michel, Romain Favre, Anne-Sophie Weingertner, Jean-François Oury, Véronique Baudouin, Jean-Paul Bory, Christine Pietrement, Maryse Fiorenza, Jérôme Massardier, Sylvie Kessler, Nadia Lounis, Françoise Conte Auriol, Pascale Marcorelles, Sophie Collardeau-Frachon, Petra Zürbig, Harald Mischak, Pedro Magalhães, Julie Batut, Patrick Blader, Jean-Sebastien Saulnier Blache, Jean-Loup Bascands, Franz Schaefer, Stéphane Decramer, Joost P. Schanstra, BIOMAN consortium
      Abstract: Although a rare disease, bilateral congenital anomalies of the kidney and urinary tract (CAKUT) are the leading cause of end stage kidney disease in children. Ultrasound-based prenatal prediction of postnatal kidney survival in CAKUT pregnancies is far from accurate. To improve prediction, we conducted a prospective multicenter peptidome analysis of amniotic fluid spanning 140 evaluable fetuses with CAKUT. We identified a signature of 98 endogenous amniotic fluid peptides, mainly composed of fragments from extracellular matrix proteins and from the actin binding protein thymosin-β4.
      Citation: Kidney International (2020)
      PubDate: 2020-08-01
      DOI: 10.1016/j.kint.2020.06.043
  • Simultaneous Glomerular Filtration Rate Determination Using Inulin,
           Iohexol and 99mTc-DTPA Demonstrates the Need for Customized Measurement
    • Authors: Christine A. White; Ayub Akbari, Celine Allen, Andrew G. Day, Patrick A. Norman, David Holland, Michael A. Adams, Greg A. Knoll
      Abstract: Urinary inulin clearance is considered the gold standard of glomerular filtration rate (GFR)measurement but plasma clearance of less expensive and more accessible tracers is more commonly performed. Many plasma sampling protocols exist but little is known about their accuracy. Here, the study objectives were to compare plasma iohexol and 99mTc-DTPA GFR with varying sampling strategies to the GFR measured by urinary inulin and to identify protocols with the greatest accuracy according to clinical characteristics.
      Citation: Kidney International (2020)
      PubDate: 2020-07-31
      DOI: 10.1016/j.kint.2020.06.044
  • The potassium regulator patiromer affects serum and stool electrolytes in
           patients receiving hemodialysis.
    • Authors: Richard L. Amdur; Rohan Paul, Elizabeth D. Barrows, Danielle Kincaid, Jagadeesan Muralidharan, Ehsan Nobakht, Patricia Centron-Vinales, Muhammad Siddiqi, Samir S. Patel, Dominic S. Raj
      Abstract: Hyperkalemia is a common and an important cause of death in maintenance hemodialysis patients. Here we investigated the effect of patiromer, a synthetic cation exchanger, to regulate potassium homeostatis. Serum and stool electrolytes were measured in 27 anuric patients with hyperkalemia receiving hemodialysis (mainly 2 mEq/L dialysate) during consecutive two weeks of no-treatment, 12 weeks of treatment with patiromer (16.8g once daily), and six weeks of no treatment. The serum potassium decreased from a mean of 5.7 mEq/L pre-treatment to 5.1 mEq/L during treatment and rebounded to 5.4 mEq/L post-treatment.
      Citation: Kidney International (2020)
      PubDate: 2020-07-31
      DOI: 10.1016/j.kint.2020.06.042
  • An International Cohort Study of Autosomal Dominant Tubulointerstitial
    • Authors: Martina Živná; Kendrah Kidd, Mohamad Zaidan, Petr Vyleťal, Veronika Barešová, Kateřina Hodaňová, Jana Sovová, Hana Hartmannová, Miroslav Votruba, Helena Trešlová, Ivana Jedličková, Jakub Sikora, Helena Hůlková, Victoria Robins, Aleš Hnízda, Jan Živný, Gregory Papagregoriou, Laurent Mesnard, Bodo B. Beck, Andrea Wenzel, Kálmán Tory, Karsten Häeffner, Matthias T.F. Wolf, Michael E. Bleyer, John A. Sayer, Albert C.M. Ong, Lídia Balogh, Anna Jakubowska, Agnieszka Łaszkiewicz, Rhian Clissold, Charles Shaw-Smith, Raj Munshi, Robert M. Haws, Claudia Izzi, Irene Capelli, Marisa Santostefano, Claudio Graziano, Francesco Scolari, Amy Sussman, Howard Trachtman, Stephane Decramer, Marie Matignon, Philippe Grimbert, Lawrence R. Shoemaker, Christoforos Stavrou, Mayssa Abdelwahed, Neila Belghith, Matthew Sinclair, Kathleen Claes, Tal Kopel, Sharon Moe, Constantinos Deltas, Bertrand Knebelmann, Luca Rampoldi, Stanislav Kmoch, Anthony J. Bleyer
      Abstract: There have been few clinical or scientific reports of autosomal dominant tubulointerstitial kidney disease due to REN mutations (ADTKD-REN), limiting characterization. To further study this, we formed an international cohort characterizing 111 individuals from 30 families with both clinical and laboratory findings. Sixty-nine individuals had a REN mutation in the signal peptide region (signal group), 27 in the prosegment (prosegment group), and 15 in the mature renin peptide (mature group). Signal group patients were most severely affected, presenting at a mean age of 19.7 years, with the prosegment group presenting at 22.4 years, and the mature group at 37 years.
      Citation: Kidney International (2020)
      PubDate: 2020-07-31
      DOI: 10.1016/j.kint.2020.06.041
  • Results of a nation-wide cohort study suggest favorable long-term outcomes
           of clone-targeted chemotherapy in immunotactoid glomerulopathy.
    • Authors: Vincent Javaugue; Léa Dufour-Nourigat, Estelle Desport, Audrey Sibille, Bruno Moulin, Pierre Bataille, Pascal Bindi, Cyril Garrouste, Christophe Mariat, Lionel Karlin, Mathilde Nouvier, Jean-Michel Goujon, Viviane Gnemmi, Jean-Paul Fermand, Guy Touchard, Frank Bridoux
      Abstract: Immunotactoid glomerulopathy is a rare disease defined by glomerular microtubular immunoglobulin deposits. Since management and long-term outcomes remain poorly described, we retrospectively analyzed results of 27 adults from 21 departments of nephrology in France accrued over19 years. Inclusion criteria were presence of glomerular Congo red-negative monotypic immunoglobulin deposits with ultrastructural microtubular organization, without evidence for cryoglobulinemic glomerulonephritis. Baseline manifestations of this cohort included: proteinuria (median 6.0 g/day), nephrotic syndrome (70%), microscopic hematuria (74%) and hypertension (56%) with a median serum creatinine of 1.5 mg/dL.
      Citation: Kidney International (2020)
      PubDate: 2020-07-30
      DOI: 10.1016/j.kint.2020.06.039
  • Sterol-O-acyltransferase-1 has a role in kidney disease associated with
           diabetes and Alport Syndrome.
    • Authors: Xiaochen Liu; Gloria Michelle Ducasa, Shamroop Kumar Mallela, Jin-Ju Kim, Judith Molina, Alla Mitrofanova, Sydney Symone Wilbon, Mengyuan Ge, Antonio Fontanella, Christopher Pedigo, Javier Varona Santos, Robert Nelson, Yelena Drexler, Gabriel Contreras, Al-Ali Hassan, Sandra Merscher, Alessia Fornoni
      Abstract: Defective cholesterol metabolism primarily linked to reduced ATP-binding cassette transporter A1 (ABCA1) expression is closely associated with the pathogenesis and progression of kidney diseases, including diabetic kidney disease and Alport Syndrome. However, whether the accumulation of free or esterified cholesterol contributes to progression in kidney disease remains unclear. Here, we demonstrate that inhibition of sterol-O-acyltransferase-1 (SOAT1), the enzyme at the endoplasmic reticulum that converts free cholesterol to cholesterol esters, which are then stored in lipid droplets, effectively reduced cholesterol ester and lipid droplet formation in human podocytes.
      Citation: Kidney International (2020)
      PubDate: 2020-07-29
      DOI: 10.1016/j.kint.2020.06.040
  • Spot urinary citrate-to-creatinine ratio is a marker for acid-base status
           in chronic kidney disease.
    • Authors: Fabiola G. Gianella; Victor E. Prado, John R. Poindexter, Beverley Adams-Huet, Xilong Li, R. Tyler Miller, Khashayar Sakhaee, Naim M. Maalouf, Orson W. Moe
      Abstract: Due to multiple compensating mechanisms, the serum bicarbonate concentration is a relatively insensitive marker of acid-base status; especially in chronic kidney disease (CKD). This is a major drawback that impairs the ability to diagnose acid excess or monitor alkali therapy. We postulated that it is more logical to measure the compensatory defense mechanism(s) rather than the defended parameter, which remains normal if the compensation is successful. Therefore, a retrospective cross-sectional study was performed in 1733 stone formers along with a prospective cross-sectional study of 22 individuals with normal kidney function and 50 patients in different stages of CKD.
      Citation: Kidney International (2020)
      PubDate: 2020-07-25
      DOI: 10.1016/j.kint.2020.07.006
  • Results from the TRIBE-AKI Study found associations between post-operative
    • Authors: Steven Menez; Dennis G. Moledina, Amit X. Garg, Heather Thiessen-Philbrook, Eric McArthur, Yaqi Jia, Caroline Liu, Wassim Obeid, Sherry G. Mansour, Jay L. Koyner, Michael G. Shlipak, Francis P. Wilson, Steven G. Coca, Chirag R. Parikh
      Abstract: Patients undergoing cardiac surgery are placed under intense physiologic stress. Blood and urine biomarkers measured peri-operatively may help identify patients at higher risk for adverse long-term kidney outcomes.We sought to determine independent associations of various biomarkers with development or progression of chronic kidney disease (CKD) following cardiac surgery. In this sub-study of the prospective cohort –TRIBE-AKI Study, we evaluated 613 adult patients undergoing cardiac surgery in Canada in our primary analysis and tested the association of 40 blood and urinary biomarkers with the primary composite outcome of CKD incidence or progression.
      Citation: Kidney International (2020)
      PubDate: 2020-07-25
      DOI: 10.1016/j.kint.2020.06.037
  • A molecular circadian clock operates in the parathyroid gland and is
    • Authors: Søren Egstrand; Anders Nordholm, Marya Morevati, Maria Lerche Mace, Alia Hassan, Tally Naveh-Many, Jakob L. Rukov, Eva Gravesen, Klaus Olgaard, Ewa Lewin
      Abstract: Circadian rhythms in metabolism, hormone secretion, cell cycle and locomotor activity are regulated by a molecular circadian clock with the master clock in the suprachiasmatic nucleus of the central nervous system. However, an internal clock is also expressed in several peripheral tissues. Although about 10% of all genes are regulated by clock machinery an internal molecular circadian clock in the parathyroid glands has not previously been investigated. Parathyroid hormone secretion exhibits a diurnal variation and parathyroid hormone gene promoter contains an E-box like element, a known target of circadian clock proteins.
      Citation: Kidney International (2020)
      PubDate: 2020-07-25
      DOI: 10.1016/j.kint.2020.06.034
  • A profile of multiple circulating tumor necrosis factor receptors
           associated with early progressive kidney decline in Type 1 Diabetes is
           similar to profiles in autoimmune disorders.
    • Authors: Katsuhito Ihara; Jan Skupien, Bozena Krolewski, Zaipul I. Md Dom, Kristina O’Neil, Eiichiro Satake, Hiroki Kobayashi, Narges M. Rashidi, Monika A. Niewczas, Andrzej S. Krolewski
      Abstract: This study comprehensively evaluated the association between known circulating tumor necrosis factor (TNF) superfamily ligands and receptors and the development of early progressive kidney decline (PKD) leading to end-stage kidney disease (ESKD) in Type 1 diabetes. Participants for the study were from the Macro-Albuminuria Study (198 individuals), and the Micro-Albuminuria Study (148 individuals) of the Joslin Kidney Study. All individuals initially had normal kidney function and were followed for seven-fifteen years to determine the slope of the estimate glomerular filtration rate and to ascertain onset of ESKD.
      Citation: Kidney International (2020)
      PubDate: 2020-07-24
      DOI: 10.1016/j.kint.2020.07.007
  • Genotype-phenotype correlations influence the response to
           angiotensin-targeting drugs in Japanese patients with male X-linked Alport
    • Authors: Tomohiko Yamamura; Tomoko Horinouchi, China Nagano, Takashi Omori, Nana Sakakibara, Yuya Aoto, Shinya Ishiko, Koichi Nakanishi, Yuko Shima, Hiroaki Nagase, Hiroki Takeda, Rini Rossanti, Ming Juan Ye, Yoshimi Nozu, Shingo Ishimori, Takeshi Ninchoji, Hiroshi Kaito, Naoya Morisada, Kazumoto Iijima, Kandai Nozu
      Abstract: Early kidney failure in the hereditary type IV collagen disease, Alport syndrome, can be delayed by renin-angiotensin inhibitors. However, whether all patients and all different genotypes respond equally well to this kidney-protective therapy remains unclear. Here, we performed a retrospective study on 430 patients with male X-linked Alport syndrome to examine the relationships among kidney prognosis, genotype, and treatment effect in a large cohort of Japanese patients. We analyzed the clinical features, genotype-phenotype correlation, and kidney survival period for patients treated with or without renin-angiotensin inhibitors.
      Citation: Kidney International (2020)
      PubDate: 2020-07-23
      DOI: 10.1016/j.kint.2020.06.038
  • A study from The Mayo Clinic evaluated long-term outcomes of kidney
           transplantation in patients with immunoglobulin light chain amyloidosis.
    • Authors: Cihan Heybeli; Andrew Bentall, Jiqiu Wen, Mariam Priya Alexander, Francis K. Buadi, Fernando Cosio, Patrick G. Dean, Angela Dispenzieri, David Dingli, Mireille El Ters, Morie A. Gertz, Amer Hatem, Prashant Kapoor, Hasan Khamash, Taxiarchis Kourelis, Shaji Kumar, Elizabeth Lorenz, Martin Mai, Eli Muchtar, David Murray, Mikel Prieto, Carrie Schinstock, Mark Stegall, Rahma Warsame, Nelson Leung
      Abstract: Longer survival using modern therapies has increased the number of patients with immunoglobulin light-chain amyloidosis receiving kidney transplantation. We evaluated 60 patients with immunoglobulin light chain amyloidosis who underwent kidney transplantation based on their hematologic response for outcomes of death, graft failure, and complications. Patient hematologic responses (light-chain in blood or urine) prior to kidney transplantation were three patients had no response, five had a partial response, six had a very good partial response, 37 had a complete response, and nine were treatment-naive patients (never treated for this disorder).
      Citation: Kidney International (2020)
      PubDate: 2020-07-23
      DOI: 10.1016/j.kint.2020.06.036
  • Fumarate modulates phospholipase A2 receptor autoimmunity-induced podocyte
           injury in membranous nephropathy.
    • Authors: Hyung Ah Jo; Jin Seong Hyeon, Seung Hee Yang, Youngae Jung, Hunjoo Ha, Chang Wook Jeong, Cheol Kwak, Yaerim Kim, Hajeong Lee, Jung Pyo Lee, Kwon Wook Joo, Chun Soo Lim, Yon Su Kim, Geum-Sook Hwang, Dong Ki Kim
      Abstract: Downstream mechanisms that lead to podocyte injury following phospholipase A2 receptor (PLA2R) autoimmunity remain elusive. To help define this we compared urinary metabolomic profiles of patients with PLA2R-associated membranous nephropathy (MN) at the time of kidney biopsy with those of patients with minimal change disease (MCD) and to healthy individuals. Among the metabolites differentially expressed in patients with PLA2R-associated MN compared to healthy individuals, fumarate was the only significant differentially expressed metabolite in PLA2R-associated MN compared to MCD [fold-difference vs.
      Citation: Kidney International (2020)
      PubDate: 2020-07-23
      DOI: 10.1016/j.kint.2020.06.031
  • A prospective cohort study that examined acute kidney injury and kidney
           outcomes, cardiovascular events and death informs on long-term clinical
    • Authors: T. Alp Ikizler; Chirag R. Parikh, Jonathan Himmelfarb, Vernon M. Chinchilli, Kathleen D. Liu, Steven G. Coca, Amit X. Garg, Chi-yuan Hsu, Edward D. Siew, Mark M. Wurfel, Lorraine B. Ware, Georgia Brown Faulkner, Thida C. Tan, James S. Kaufman, Paul L. Kimmel, Alan S. Go, ASSESS-AKI Study Investigators
      Abstract: Acute kidney injury (AKI) has been reported to be associated with excess risks of death, kidney disease progression and cardiovascular events although previous studies have important limitations. To further examine this, we prospectively studied adults from four clinical centers surviving three months and more after hospitalization with or without AKI who were matched on center, pre-admission CKD status, and an integrated priority score based on age, prior cardiovascular disease or diabetes mellitus, preadmission estimated glomerular filtration rate (eGFR) and treatment in the intensive care unit during the index hospitalization between December 2009-February 2015, with follow-up through November 2018.
      Citation: Kidney International (2020)
      PubDate: 2020-07-21
      DOI: 10.1016/j.kint.2020.06.032
  • Surveying the Human Single Cell Landscape
    • Authors: Haikuo Li; Benjamin D. Humphreys
      Abstract: Refers to: Han X, Zhou Z, Fei L, et al. Construction of a human cell landscape at single-cell level. Nature. 2020;581(October 2018). doi:10.1038/s41586-020-2157-4
      Citation: Kidney International (2020)
      PubDate: 2020-07-14
      DOI: 10.1016/j.kint.2020.06.027
  • Genetic variation in claudin-2, hypercalciuria and kidney stones
    • Authors: Valentine Gillion; Olivier Devuyst
      Abstract: Idiopathic hypercalciuria is a major risk factor for kidney stones, which affect 5 to 10% of the population and are increasing on a global scale. Potential causes for idiopathic hypercalciuria include increased intestinal absorption, abnormal bone resorption, and reduced reabsorption of calcium by the kidney (1). In steady state, the kidney tubules reabsorb approximately 98% of the filtrated Ca2+, via transcellular and paracellular pathways. The transcellular pathway is mediated by transporters expressed in the apical and basolateral membrane domains of cells, whereas the paracellular pathway depends on transepithelial electrochemical gradients and involves specialized proteins, the claudins (2).
      Citation: Kidney International (2020)
      PubDate: 2020-07-09
      DOI: 10.1016/j.kint.2020.05.055
  • Hyperuricemia As a trigger of Immune Response in Hypertension and Chronic
           Kidney Disease
    • Authors: Claudio Ponticelli; Manuel Alfredo Podestà, Gabriella Moroni
      Abstract: Accumulating evidence indicates that asymptomatic hyperuricemia is involved in the development of hypertension and chronic kidney disease. A two-hit model has been proposed to explain the role of urate in hypertension. The first hit entails activation of the renin-angiotensin system and inhibition of nitric oxide synthesis, which promote endothelial dysfunction, proliferation of vascular smooth-muscle cells and sodium reabsorption, leading to a moderate but consistent increase in systemic blood pressure.
      Citation: Kidney International (2020)
      PubDate: 2020-07-07
      DOI: 10.1016/j.kint.2020.05.056
  • Interleukin 6 levels after tocilizumab administration in transplant
           recipients with COVID-19
    • Authors: Akhil R. Gade; Harshitha Alavala, Sridhar R. Allam
      Abstract: It is with great interest we read the article by Gautier-Vargas and colleagues that reported favorable clinical response with tocilizumab in a kidney transplant recipient with severe coronavirus disease 2019 (COVID-19) 1. Our clinical experience has also been similar 2.
      Authors reported dramatic decrease of serum interleukin 6 (IL-6) level from 430.8 pg/mL to 3.4 pg/mL within 2 days after administration of tocilizumab. However, as previously published 3-4, and in our own experience, IL-6 levels generally increase after administration of tocilizumab.
      Citation: Kidney International (2020)
      PubDate: 2020-07-07
      DOI: 10.1016/j.kint.2020.06.025
  • Practical management of C3 glomerulopathy and immunoglobulin-mediated
           MPGN: facts and uncertainties.
    • Authors: Fadi Fakhouri; Moglie Le Quintrec, Véronique Frémeaux-Bacchi
      Abstract: In recent years, a substantial body of experimental and clinical work has been devoted to C3 glomerulopathy and immunoglobulin-mediated membranoproliferative glomerulonephritis. Despite the rapid accumulation of data, several uncertainties regarding these two rare forms of nephropathies persist. They concern their pathophysiology, classification, clinical course, relevance of biomarkers and of pathology findings and assessment of the efficacy of available therapies. The present review discusses the impact of these uncertainties on the clinical management of patients.
      Citation: Kidney International (2020)
      PubDate: 2020-07-02
      DOI: 10.1016/j.kint.2020.05.053
  • The prevalence of chronic kidney disease in Iceland according to KDIGO
    • Authors: Arnar J. Jonsson; Sigrun H. Lund, Bjørn O. Eriksen, Runolfur Palsson, Olafur S. Indridason
      Abstract: Most epidemiological studies on chronic kidney disease (CKD) are based solely on estimated glomerular filtration rates (eGFR). Few studies have included proteinuria, while the chronicity criterion is usually omitted. To explore this, we examined the prevalence of CKD stages 1-5 in Iceland based on multiple markers of kidney damage. All serum creatinine values, urine protein measurements and diagnostic codes for kidney diseases and comorbid conditions for people aged 18 years and older were obtained from electronic medical records of all healthcare institutions in Iceland in 2008-2016.
      Citation: Kidney International (2020)
      PubDate: 2020-07-02
      DOI: 10.1016/j.kint.2020.06.017
  • Evaluating multiple living kidney donor candidates simultaneously is more
           cost-effective than sequentially.
    • Authors: Steven Habbous; Lianne Barnieh, Scott Klarenbach, Braden Manns, Sisira Sarma, Mehmet A. Begen, Kenneth Litchfield, Krista L. Lentine, Sunita Singh, Amit X. Garg
      Abstract: When multiple living donor candidates come forward to donate a kidney to the same recipient, some living donor programs evaluate one candidate at a time to avoid unnecessary evaluations. Evaluating multiple candidates concurrently rather than sequentially may be cost-effective from a societal perspective if it reduces the time recipients spend on dialysis. We used a simple decision tree to estimate the cost-effectiveness of evaluating two to four candidates simultaneously rather than sequentially as potential kidney donors for the same intended recipient.
      Citation: Kidney International (2020)
      PubDate: 2020-06-30
      DOI: 10.1016/j.kint.2020.06.015
  • Genetic reduction of cilium-length by targeting intraflagellar transport
           88 protein impedes kidney and liver cysts formation in mouse models of
           autosomal polycystic kidney disease.
    • Authors: Lina Shao; Wassim El-Jouni, Fanwu Kong, Janani Ramesh, Radhe Shantha Kumar, Xiaogang Shen, Jingjing Ren, Shruti Devendra, Arianna Dorschel, Maoqing Wu, Ivan Barrera, Azadeh Tabari, Kang Hu, Nadeem Haque, Ilyas Yambayev, Shiqi Li, Amresh Kumar, Tapas Ranjan Behera, Gregory McDonough, Masahito Furuich, Michael Xifaras, Tzongshi Lu, Rami Mohammad Alhayaza, Koji Miyabayashi, Qiuling Fan, Amrendra K. Ajay, Jing Zhou
      Abstract: Polycystin-1 (PC1) and -2 (PC2), products of the PKD1 and PKD2 genes, are mutated in autosomal dominant polycystic kidney disease (ADPKD). They localize to the primary cilia; however, their ciliary function is in dispute. Loss of either the primary cilia or PC1or PC2 causes cyst formation. However, loss of both cilia and PC1 or PC2 inhibits cyst growth via an unknown pathway. To help define a pathway, we studied cilium length in human and mouse kidneys. We found cilia are elongated in kidneys from patients with ADPKD and from both Pkd1 and Pkd2 knockout mice.
      Citation: Kidney International (2020)
      PubDate: 2020-06-28
      DOI: 10.1016/j.kint.2020.05.049
    • Authors: Wei Liang; Kosuke Yamahara, Camila Hernando-Erhard, Simon Lagies, Nicola Wanner, Huan Liang, Christoph Schell, Bernd Kammerer, Tobias B. Huber, Tillmann Bork
      Abstract: Podocyte maintenance and stress resistance are exquisitely based on high basal rates of autophagy making these cells a unique model to unravel mechanisms of autophagy regulation. Polyamines have key cellular functions such as proliferation, nucleic acid biosynthesis and autophagy. Here we test whether endogenous spermidine signaling is a driver of basal and dynamic autophagy in podocytes by using genetic and pharmacologic approaches to interfere with different steps of polyamine metabolism. Translational studies revealed altered spermidine signaling in focal segmental glomerulosclerosis in vivo and in vitro.
      Citation: Kidney International (2020)
      PubDate: 2020-06-27
      DOI: 10.1016/j.kint.2020.06.016
  • The clinicopathologic spectrum of segmental membranous glomerulopathy.
    • Authors: Satoru Kudose; Dominick Santoriello, Hanna Debiec, Pietro A. Canetta, Andrew S. Bomback, M. Barry Stokes, Ibrahim Batal, Pierre Ronco, Vivette D. D’Agati, Glen S. Markowitz
      Abstract: Membranous glomerulopathy (MGN) is characterized by global subepithelial immune deposits that stain most intensely by immunofluorescence for IgG. Here we describe the clinical and pathologic findings in a cohort of patients with MGN in which, by definition, only segmental immune deposits are present. This rare variant, termed segmental MGN (sMGN), is poorly characterized. We retrospectively identified all patients with sMGN diagnosed at Columbia University from January 2010 to October 2018, excluding those with systemic lupus erythematosus.
      Citation: Kidney International (2020)
      PubDate: 2020-06-26
      DOI: 10.1016/j.kint.2020.06.014
  • The role of hypoxia in the pathogenesis of lupus nephritis
    • Authors: Yu Kurata; Tetsuhiro Tanaka, Masaomi Nangaku
      Abstract: Systemic Lupus Erythematosus (SLE) is a systemic autoimmune disease of multifactorial etiology. T cells play an important role in the pathogenesis of SLE by amplifying inflammatory responses and helping B cells to produce autoantibodies. Naïve T cells are activated by recognition of an antigen signal and initiate immune responses including differentiation, expansion, and effector functions. Activated T cells shift their metabolic program toward glycolysis in order to generate energy and biosynthetic precursors.
      Citation: Kidney International (2020)
      PubDate: 2020-06-26
      DOI: 10.1016/j.kint.2020.06.008
  • Global transcriptomic changes occur in aged mouse podocytes.
    • Authors: Yuliang Wang; Diana G. Eng, Natalya V. Kaverina, Carol J. Loretz, Abbal Koirala, Shreeram Akilesh, Jeffrey W. Pippin, Stuart J. Shankland
      Abstract: Glomerular podocytes undergo structural and functional changes with advanced age, that; increase susceptibility of aging kidneys to worse outcomes following superimposed glomerular; diseases. To delineate transcriptional changes in podocytes in aged mice, RNA-seq was performed on isolated populations of reporter-labeled (tdTomato) podocytes from multiple young (two to three months) and advanced aged mice (22 to 24 months, equivalent to 70 plus year old humans). Of the 2,494 differentially expressed genes, 1,219 were higher and 1,275 were lower in aged podocytes.
      Citation: Kidney International (2020)
      PubDate: 2020-06-24
      DOI: 10.1016/j.kint.2020.05.052
  • Nuclear antigen-reactive CD4+ T cells expand in active systemic lupus
           erythematosus, produce effector cytokines, and invade the kidneys.
    • Authors: Dimas Abdirama; Sebastian Tesch, Anna-Sophie Grießbach, Caroline von Spee-Mayer, Jens Y. Humrich, Ulrik Stervbo, Nina Babel, Christian Meisel, Tobias Alexander, Robert Biesen, Petra Bacher, Alexander Scheffold, Kai-Uwe Eckardt, Falk Hiepe, Andreas Radbruch, Gerd-Rüdiger Burmester, Gabriela Riemekasten, Philipp Enghard
      Abstract: Systemic lupus erythematosus is a systemic and chronic autoimmune disease characterized by loss of tolerance towards nuclear antigens with autoreactive CD4+ T cells implicated in disease pathogenesis. However, very little is known about their receptor specificity since the detection of human autoantigen specific CD4+ T cells has been extremely challenging. Here we present an analysis of CD4+ T cells reactive to nuclear antigens using two complementary methods: T cell libraries and antigen-reactive T cell enrichment.
      Citation: Kidney International (2020)
      PubDate: 2020-06-24
      DOI: 10.1016/j.kint.2020.05.051
  • Low dose L-NAME induces salt sensitivity associated with sustained
           increased blood volume and sodium-chloride cotransporter activity in
    • Authors: Conghui Wang; Fumiko Kawakami-Mori, Lei Kang, Nobuhiro Ayuzawa, Sayoko Ogura, Suang Suang Koid, Latapati Reheman, Alimila Yeerbolati, Beibei Liu, Yutaka Yatomi, Xiangmei Chen, Toshiro Fujita, Tatsuo Shimosawa
      Abstract: To investigate the cause of salt sensitivity in a normotensive animal model, we treated rats with a low-dose of the nitric oxide synthase inhibitor, L-NAME, that does not elevate blood pressure per se or induce kidney fibrosis. A high salt diet increased the circulating blood volume both in L-NAME-treated and nontreated animals for the first 24 hours. Thereafter, the blood volume increase persisted only in the L-NAME-treated rats. Blood pressure was higher in the L-NAME-treated group from the start of high salt diet exposure.
      Citation: Kidney International (2020)
      PubDate: 2020-06-24
      DOI: 10.1016/j.kint.2020.05.050
  • Visualization of sodium dynamics in the kidney by magnetic resonance
           imaging by a multisite study.
    • Authors: James T. Grist; Frank Riemer, Esben Hansen, Rasmus S. Tougaard, Mary A. McLean, Joshua Kaggie, Nikolaj Bøgh, Martin J. Graves, Ferdia A. Gallagher, Christoffer Laustsen
      Abstract: Sodium magnetic resonance imaging (MRI) is a powerful, non-invasive technique to assess the sodium distribution within the kidney. Here we undertook pre-clinical and clinical studies to quantify the corticomedullary sodium gradient in healthy individuals and in a porcine model of diuresis. The results demonstrated that sodium MRI could detect spatial differences in sodium biodistribution across the kidney. The sodium gradient of the kidney changed significantly after diuresis in the pig model and was independent of blood electrolyte measurements.
      Citation: Kidney International (2020)
      PubDate: 2020-06-21
      DOI: 10.1016/j.kint.2020.04.056
  • Carbonyl iron and iron dextran therapies cause adverse effects on bone
           health in juveniles with chronic kidney disease.
    • Authors: Edwin Patino; Stephen B. Doty, Divya Bhatia, Kelly Meza, Yuan-Shan Zhu, Stefano Rivella, Mary E. Choi, Oleh Akchurin
      Abstract: Anemia is a frequent complication of chronic kidney disease (CKD), related in part to the disruption of iron metabolism. Iron therapy is very common in children with CKD and excess iron has been shown to induce bone loss in non-CKD settings, but the impact of iron on bone health in CKD remains poorly understood. Here, we evaluated the effect of oral and parenteral iron therapy on bone transcriptome, bone histology and morphometry in two mouse models of; juvenile CKD (adenine-induced and 5/6-nephrectomy).
      Citation: Kidney International (2020)
      PubDate: 2020-06-20
      DOI: 10.1016/j.kint.2020.05.043
  • Off the beaten track: defining the developmental path of T cells through
           the human Thymus
    • Authors: Juewan Kim; Jacqueline Scaffidi, P. Toby Coates
      Abstract: The thymus is a primary lymphoid organ in which T cells are developed and T cell receptor repertoire is formed. T cell development starts when T cell precursors migrate from the bone marrow or the foetal liver to the thymus.1 In the thymic microenvironment, these precursor cells undergo a series of differentiation and selection events in different regions of the thymus, resulting in a diverse repertoire of mature T cells to establish immune protection against foreign antigens and immune tolerance towards self-antigens2.
      Citation: Kidney International (2020)
      PubDate: 2020-06-19
      DOI: 10.1016/j.kint.2020.05.047
  • Deletion of the myeloid endothelin-B receptor confers long-term protection
           from angiotensin II-mediated kidney, eye and vessel injury.
    • Authors: Léa Guyonnet; Alicja Czopek, Tariq E. Farrah, Véronique Baudrie, Philippe Bonnin, Anna Chipont, Olivia Lenoir, Florian Sennlaub, Christophe Roubeix, David J. Webb, David C. Kluth, Matthew A. Bailey, Pierre-Louis Tharaux, Neeraj Dhaun
      Abstract: The endothelin system may be an important player in hypertensive end-organ injury as endothelin-1 increases blood pressure and is pro-inflammatory. The immune system is emerging as an important regulator of blood pressure and we have shown that the early hypertensive response to angiotensin-II infusion was amplified in mice deficient of myeloid endothelin-B (ETB) receptors (LysM-CreEdnrblox/lox). Hypothesizing that these mice would display enhanced organ injury, we gave angiotensin-II to LysM-CreEdnrblox/lox and littermate controls (Ednrblox/lox) for six weeks.
      Citation: Kidney International (2020)
      PubDate: 2020-06-19
      DOI: 10.1016/j.kint.2020.05.042
  • Data from the ERA-EDTA Registry was examined for trends in excess
           mortality in European adults on kidney replacement therapy.
    • Authors: Rianne Boenink; Vianda S. Stel, Bård E. Waldum-Grevbo, Frederic Collart, Julia Kerschbaum, James G. Heaf, Johan de Meester, Patrik Finne, Sergio A. García-Marcos, Marie Evans, Patrice M. Ambühl, Mustafa Arici, Carole Ayav, Retha Steenkamp, Aleix Cases, Jamie P. Traynor, Runolfur Palsson, Carmine Zoccali, Ziad A. Massy, Kitty J. Jager, Anneke Kramer
      Abstract: The objective of this study was to investigate whether the improvement in survival seen in patients on kidney replacement therapy reflects the enhanced survival of the general population. Patient and general population statistics were obtained from the European Renal Association-European Dialysis and Transplant Association (ERA-EDTA) Registry and the World Health Organization databases, respectively. Relative survival models were composed to examine trends over time in all-cause and cause-specific excess mortality, stratified by age and modality of kidney replacement therapy, and adjusted for sex, primary kidney disease and country.
      Citation: Kidney International (2020)
      PubDate: 2020-06-19
      DOI: 10.1016/j.kint.2020.05.039
  • A New Player in the Kidney-Bone Axis: Regulation of fibroblast growth
           factor-23 by renal glycerol-3-phosphate
    • Authors: Ziad A. Massy; Tilman B. Drueke
      Abstract: Fibroblast growth factor-23 (FGF23) is a bone-derived hormone that regulates phosphate handling and vitamin D activation in the kidney. High circulating FGF23 levels are associated with an increased risk of all-cause and cardiovascular mortality not only in patients with chronic kidney disease (CKD) but also in the general population, independent of other risk factors. Furthermore, FGF23 has been shown to promote left ventricular hypertrophy in experimental animals and to induce cardiomyocyte hypertrophy in vitro.
      Citation: Kidney International (2020)
      PubDate: 2020-06-18
      DOI: 10.1016/j.kint.2020.05.037
  • Common risk variants in NPHS1 and TNFSF15 are associated with childhood
           steroid-sensitive nephrotic syndrome
    • Authors: Xiaoyuan Jia; Tomohiko Yamamura, Rasheed Gbadegesin, Michelle T. McNulty, Kyuyong Song, China Nagano, Yuki Hitomi, Dongwon Lee, Yoshihiro Aiba, Seik-Soon Khor, Kazuko Ueno, Yosuke Kawai, Masao Nagasaki, Eisei Noiri, Tomoko Horinouchi, Hiroshi Kaito, Riku Hamada, Takayuki Okamoto, Koichi Kamei, Yoshitsugu Kaku, Rika Fujimaru, Ryojiro Tanaka, Yuko Shima, The Research Consortium on Genetics of Childhood Idiopathic Nephrotic Syndrome in Japan, Jiwon Baek, Hee Gyung Kang, Il-Soo Ha, Kyoung Hee Han, Eun Mi Yang, Korean Consortium of Hereditary Renal Diseases in Children, Asiri Abeyagunawardena, Brandon Lane, Megan Chryst-Stangl, Christopher Esezobor, Adaobi Solarin, Midwest Pediatric Nephrology Consortium (Genetics of nephrotic syndrome study group), Claire Dossier, Georges Deschênes, NEPHROVIR, Marina Vivarelli, Hanna Debiec, Kenji Ishikura, Masafumi Matsuo, Kandai Nozu, Pierre Ronco, Hae Il Cheong, Matthew G. Sampson, Katsushi Tokunaga, Kazumoto Iijima
      Abstract: To understand the genetics of steroid-sensitive nephrotic syndrome (SSNS), we conducted a genome-wide association study in 987 childhood SSNS patients and 3,206 healthy controls with Japanese ancestry. Beyond known associations in the HLA-DR/DQ region, common variants in NPHS1-KIRREL2 (rs56117924, P=4.94E-20, odds ratio (OR) =1.90) and TNFSF15 (rs6478109, P=2.54E-8, OR=0.72) regions achieved genome-wide significance and were replicated in Korean, South Asian and African populations. Trans-ethnic meta-analyses including Japanese, Korean, South Asian, African, European, Hispanic and Maghrebian populations confirmed the significant associations of variants in NPHS1-KIRREL2 (Pmeta=6.71E-28, OR=1.88) and TNFSF15 (Pmeta=5.40E-11, OR=1.33) loci.
      Citation: Kidney International (2020)
      PubDate: 2020-06-13
      DOI: 10.1016/j.kint.2020.05.029
  • Derivation and Validation of Genome Wide Polygenic Score for Urinary Tract
           Stone Diagnosis
    • Authors: Ishan Paranjpe; Noah Tsao, Renae Judy, Manish Paranjpe, Kumardeep Chaudhary, Derek Klein, Iain Forrest, Ross O’Hagan, Arjun Kapoor, John Pfail, Suraj Jaladanki, Fayzan Chaudhry, Akhil Vaid, Phan Q. Duy, CBIPM Genomics Team, Regeneron Genomics Team, John Cijiang He, Benjamin S. Glicksberg, Steven G. Coca, Mantu Gupta, Ron Do, Scott M. Damrauer, Girish N. Nadkarni
      Abstract: Urinary tract stones have high heritability indicating a strong genetic component. However, genome wide association studies (GWAS) have uncovered only a few genome wide significant single nucleotide polymorphisms (SNPs). Polygenic risk scores (PRS) sum cumulative effect of many SNPs and shed light on underlying genetic architecture. Using GWAS summary statistics from 361,141 participants in the United Kingdom Biobank, we generated a PRS and determined association with stone diagnosis in 28,877 participants in the Mount Sinai BioMe Biobank.
      Citation: Kidney International (2020)
      PubDate: 2020-06-12
      DOI: 10.1016/j.kint.2020.04.055
  • Derivation and external validation of the SIMPLICITY Score as a simple
           immune-based risk score to predict infection in kidney transplant
    • Authors: Mario Fernández-Ruiz; Daniel Seron, Ángel Alonso, David Lora, Domingo Hernández, Esther González, María José Pérez-Sáez, Gonzalo Gómez, Luis Manuel Pallardó-Mateu, Luisa Jimeno-García, Frederic Cofán, Alex Gutierrez-Dalmau, Juan Carlos Ruiz, Ana Ramírez-Puga, Raquel Santana Estupiñán, Roberto Marcén, José María Portolés, Miguel Ángel Muñoz-Cepeda, Francisco López-Medrano, Rafael San Juan, Amado Andrés, José María Aguado, Spanish Network for Research in Infectious Diseases (REIPI RD16/0016), Spanish Network for Research in Renal Diseases (REDinREN RD16/0009)
      Abstract: Existing approaches for infection risk stratification in kidney transplant recipients aresuboptimal. Here, we aimed to develop and validate a weighted score integrating non-pathogen-specific immune parameters and clinical variables to predict the occurrence of post-transplant infectious complications. To this end, we retrospectively analyzed a single-center derivation cohort of 410 patients undergoing kidney transplantation in 2008-2013 in Madrid. Peripheral blood lymphocyte subpopulations, serum immunoglobulin and complement levels were measured at one-month post-transplant.
      Citation: Kidney International (2020)
      PubDate: 2020-06-12
      DOI: 10.1016/j.kint.2020.04.054
  • Mutation of complement factor B causing massive fluid-phase dysregulation
           of the alternative complement pathway can result in atypical hemolytic
           uremic syndrome
    • Authors: Yuzhou Zhang; Robin Kremsdorf, C. John Sperati, Kammi J. Henriksen, Mari Mori, Renee X. Goodfellow, Gabriella R. Pitcher, Cindy Benson, Nicolo Ghiringhelli Borsa, Ronald P. Taylor, Carla M. Nester, Richard JH. Smith
      Abstract: Atypical hemolytic uremic syndrome is an ultra-rare disease characterized by microangiopathic hemolytic anemia, thrombocytopenia and acute kidney injury. Its pathogenesis is driven most frequently by dysregulated cell-surface control of the alternative pathway of complement secondary to inherited and/or acquired factors. Here we evaluated two unrelated patients with atypical hemolytic uremic syndrome. The first, a five-year-old Caucasian female, presented at 10 months with schistocytes, thrombocytopenia and kidney injury.
      Citation: Kidney International (2020)
      PubDate: 2020-06-12
      DOI: 10.1016/j.kint.2020.05.028
  • Semaphorin 3B-associated membranous nephropathy is a distinct type of
           disease predominantly present in pediatric patients.
    • Authors: Sanjeev Sethi; Hanna Debiec, Benjamin Madden, Marina Vivarelli, M. Cristine Charlesworth, Aishwarya Ravindran, LouAnn Gross, Tim Ulinski, David Buob, Cheryl L. Tran, Francesco Emma, Francesca Diomedi-Camassei, Fernando C. Fervenza, Pierre Ronco
      Abstract: Membranous nephropathy results from subepithelial antigen-antibody complex deposition along the glomerular basement membrane. Although PLA2R, THSD7A, and NELL-1 account for a majority (about 80%) of the target antigens, the target antigen in the remaining cases is not known. Using laser microdissection of PLA2R-negative glomeruli of patients with membranous nephropathy followed by mass spectrometry we identified a unique protein, Semaphorin 3B, in three cases. Mass spectrometry failed to detect Semaphorin-3B in 23 PLA2R-associated cases of membranous nephropathy and 88 controls.
      Citation: Kidney International (2020)
      PubDate: 2020-06-10
      DOI: 10.1016/j.kint.2020.05.030
  • Salt, but not protein intake, is associated with accelerated disease
           progression in autosomal dominant polycystic kidney disease.
    • Authors: Bart J. Kramers; Iris W. Koorevaar, Joost P.H. Drenth, Johan W. de Fijter, Antonio Gomes Neto, Dorien J.M. Peters, Priya Vart, Jack F. Wetzels, Robert Zietse, Ron T. Gansevoort, Esther Meijer
      Abstract: In autosomal dominant polycystic kidney disease (ADPKD), there are only scarce data on the effect of salt and protein intake on disease progression. Here we studied association of these dietary factors with the rate of disease progression in ADPKD, and what the mediating factors are by analyzing an observational cohort of 589 patients with ADPKD. Salt and protein intake were estimated from 24-hour urine samples and the plasma copeptin concentration measured as a surrogate for vasopressin. The association of dietary intake with annual change in the estimated glomerular filtration rate (eGFR) and height adjusted total kidney volume (htTKV) growth was analyzed with mixed models.
      Citation: Kidney International (2020)
      PubDate: 2020-06-10
      DOI: 10.1016/j.kint.2020.04.053
  • Novel Nephronophthisis-associated variants reveal functional importance of
           MAPKBP1 dimerization for centriolar recruitment
    • Authors: Ria Schönauer; Wenjun Jin, Anastasia Ertel, Melanie Nemitz-Kliemchen, Nydia Panitz, Elena Hantmann, Anna Seidel, Daniela A. Braun, Shirlee Shril, Matthias Hansen, Khurrum Shahzad, Richard Sandford, Sophie Saunier, Alexandre Benmerah, Carsten Bergmann, Friedhelm Hildebrandt, Jan Halbritter
      Abstract: Biallelic mutations in MAPKBP1 were recently associated with late-onset cilia-independent nephronophthisis. MAPKBP1 was found at mitotic spindle poles but could not be detected at primary cilia or centrosomes. Here, by identification and characterization of novel MAPKBP1 variants, we aimed at further investigating its role in health and disease. Genetic analysis was done by exome sequencing, homozygosity mapping, and a targeted kidney gene panel while co-immunoprecipitation was used to explore wildtype and mutant protein-protein interactions.
      Citation: Kidney International (2020)
      PubDate: 2020-06-04
      DOI: 10.1016/j.kint.2020.05.027
  • Hyponatremia in the cancer patient
    • Authors: Biruh T. Workeneh; Kenar D. Jhaveri, Helbert Rondon-Berrios
      Abstract: Hyponatremia is a common electrolyte disorder observed in a wide variety of malignancies and is associated with substantial morbidity and mortality. Newer cancer therapies have improved patient outcomes while also contributing to new cases of hyponatremia. Patients should be monitored closely for the development of vasopressin and non-vasopressin mediated hyponatremia. Acute and symptomatic forms of hyponatremia require urgent intervention, and recent findings also support the correction of chronic “asymptomatic” hyponatremia.
      Citation: Kidney International (2020)
      PubDate: 2020-06-01
      DOI: 10.1016/j.kint.2020.05.015
  • Phasor approach to autofluorescence lifetime imaging FLIM can be a
           quantitative biomarker of chronic renal parenchymal injury
    • Authors: Suman Ranjit; Kammi Henriksen, Alexander Dvornikov, Marco Delsante, Avi Rosenberg, Moshe Levi, Enrico Gratton
      Abstract: Diabetic kidney disease continues to be the leading cause of chronic kidney disease, often advancing to end stage kidney disease. In addition to the well characterized glomerular alterations including mesangial expansion, podocyte injury, and glomerulosclerosis, tubulointerstitial fibrosis is also an important component of diabetic kidney injury. Similarly, tubulointerstitial fibrosis is a critical component of any chronic kidney injury. Therefore, sensitive and quantitative identification of tubulointerstitial fibrosis is critical for the assessment of long-term prognosis of kidney disease.
      Citation: Kidney International (2020)
      PubDate: 2020-05-27
      DOI: 10.1016/j.kint.2020.02.019
  • CRISPR/Cas9–mediated metabolic pathway reprogramming in a novel
           humanized rat model ameliorates primary hyperoxaluria type 1.
    • Authors: Rui Zheng; Yueyan Li, Liren Wang, Xiaoliang Fang, Junqi Zhang, Lei He, Lei Yang, Dali Li, Hongquan Geng
      Abstract: Primary hyperoxaluria type I is caused by mutations in the alanine glyoxylate aminotransferase gene (AGXT), leading to accumulation of glyoxylate and subsequent production of oxalate and urolithiasis. Here, we generated a novel rat model of primary hyperoxaluria type I that carries a D205N mutation in the partially humanized Agxt gene through the CRISPR/Cas9 system. The AgxtD205N mutant rats showed undetectable alanine glyoxylate aminotransferase protein expression, developed hyperoxaluria at 1 month of age and exhibited severe renal calcium oxalate deposition after ethylene glycol challenge.
      Citation: Kidney International (2020)
      PubDate: 2020-05-25
      DOI: 10.1016/j.kint.2020.04.049
  • Intestinal microbiota controls acute kidney injury severity by immune
    • Authors: Jihyun Yang; Chan Johng Kim, Yoon Sook Go, Hee Young Lee, Myung Gyu Kim, Se Won Oh, Won Yong Cho, Sin-Hyeog Im, Sang Kyung Jo
      Abstract: Intestinal microbiota impacts the host immune system and influences the outcomes of chronic diseases. However, it remains uncertain whether acute kidney injury (AKI) impacts intestinal microbiota or vice versa. To determine this, we investigated the mechanistic link between AKI, microbiota, and immune response in ischemia/reperfusion injury. Microbiota alteration and its biological consequences after ischemia/reperfusion injury were examined and the effect of dysbiotic microbiota on the outcome of AKI was also assessed by colonizing germ-free mice with post-AKI microbiota.
      Citation: Kidney International (2020)
      PubDate: 2020-05-25
      DOI: 10.1016/j.kint.2020.04.048
  • Improving treatment decisions using personalized risk assessment from the
           International IgA Nephropathy Prediction Tool
    • Authors: Sean J. Barbour; Mark Canney, Rosanna Coppo, Hong Zhang, Zhi-Hong Liu, Yusuke Suzuki, Keiichi Matsuzaki, Ritsuko Katafuchi, Dilshani Induruwage, Lee Er, Heather N. Reich, John Feehally, Jonathan Barratt, Daniel C. Cattran, International IgA Nephropathy Network
      Abstract: Immunosuppression in IgA nephropathy (IgAN) should be reserved for patients at high-risk of disease progression, which KDIGO guidelines determine based solely on proteinuria 1g or more/day. To investigate if treatment decisions can be more accurately accomplished using individualized risk from the International IgAN Prediction Tool, we simulated allocation of a hypothetical immunosuppression therapy in an international cohort of adults with IgAN. Two decision rules for treatment were applied based on proteinuria 1g or more/day or predicted risk from the Prediction Tool above a threshold probability.
      Citation: Kidney International (2020)
      PubDate: 2020-05-25
      DOI: 10.1016/j.kint.2020.04.042
  • Baclofen has a risk of encephalopathy in older adults receiving dialysis.
    • Authors: Kianna J. Chauvin; Peter G. Blake, Amit X. Garg, Matthew A. Weir, Lavanya Bathini, Stephanie N. Dixon, Eric McArthur, Jessica M. Sontrop, Louise Moist, Richard B. Kim, Flory T. Muanda
      Abstract: At least 23 case reports link the muscle relaxant baclofen to encephalopathy in patients receiving dialysis. To explore this issue, we conducted a study to quantify the risk of encephalopathy from baclofen in patients receiving dialysis. Linked healthcare databases were used to conduct a population-based cohort study of older adults receiving maintenance dialysis in Ontario, Canada (1997-2018) to compare new users of baclofen to non-users. The primary outcome was the 30-day risk of hospitalization with encephalopathy, defined as a main diagnosis of delirium, disorientation, transient alteration of awareness, or transient cerebral ischemic attack.
      Citation: Kidney International (2020)
      PubDate: 2020-05-22
      DOI: 10.1016/j.kint.2020.04.047
  • After ten years of follow-up, no difference between supportive care plus
           immunosuppression and supportive care alone in IgA nephropathy.
    • Authors: Thomas Rauen; Stephanie Wied, Christina Fitzner, Frank Eitner, Claudia Sommerer, Martin Zeier, Britta Otte, Ulf Panzer, Klemens Budde, Urs Benck, Peter R. Mertens, Uwe Kuhlmann, Oliver Witzke, Oliver Gross, Volker Vielhauer, Johannes F.E. Mann, Ralf-Dieter Hilgers, Jürgen Floege, STOP-IgAN investigators
      Abstract: The randomized, controlled STOP-IgAN trial in patients with IgA nephropathy (IgAN) and substantial proteinuria showed no benefit of immunosuppression added on top of supportive care on renal function over three years. As a follow-up we evaluated renal outcomes in patients over a follow-up of up to ten years in terms of serum creatinine, proteinuria, end-stage kidney disease (ESKD), and death. The adapted primary endpoint was the time to first occurrence of a composite of death, ESKD, or a decline of over 40% in the estimated glomerular filtration rate (eGFR) compared to baseline at randomization into STOP-IgAN.
      Citation: Kidney International (2020)
      PubDate: 2020-05-22
      DOI: 10.1016/j.kint.2020.04.046
  • Human and mouse studies establish TBX6 in Mendelian CAKUT and as a
           potential driver of kidney defects associated with the 16p11.2
           microdeletion syndrome
    • Authors: Nan Yang; Nan Wu, Shuangshuang Dong, Ling Zhang, Yanxue Zhao, Weisheng Chen, Renqian Du, Chengcheng Song, Xiaojun Ren, Jiaqi Liu, Davut Pehlivan, Zhenlei Liu, Rao Jia, Chunyan Wang, Sen Zhao, Amy M. Breman, Huadan Xue, Hao Sun, Jianxiong Shen, Shuyang Zhang, Jennifer E. Posey, Hong Xu, Li Jin, Jianguo Zhang, Pengfei Liu, Simone Sanna-Cherchi, Guixing Qiu, Zhihong Wu, James R. Lupski, Feng Zhang
      Abstract: Congenital anomalies of the kidney and urinary tract (CAKUT) are the most common cause of chronic kidney disease in children. Human 16p11.2 deletions have been associated with CAKUT, but the responsible molecular mechanism remains to be illuminated. To explore this, we investigated 102 carriers of 16p11.2 deletion from multi-center cohorts, among which we retrospectively ascertained kidney morphologic and functional data from 37 individuals (12 Chinese and 25 Caucasian/Hispanic). Significantly higher CAKUT rates were observed in 16p11.2 deletion carriers (about 25% in Chinese and 16% in Caucasian/Hispanic) than those found in the non-clinically ascertained general populations (about 1/1000 found at autopsy).
      Citation: Kidney International (2020)
      PubDate: 2020-05-22
      DOI: 10.1016/j.kint.2020.04.045
  • Different subpopulations of kidney interstitial cells produce
           erythropoietin and factors supporting tissue oxygenation in response to
           hypoxia in vivo.
    • Authors: Katharina A.E. Broeker; Michaela A.A. Fuchs, Julia Schrankl, Birgül Kurt, Karen A. Nolan, Roland H. Wenger, Rafael Kramann, Charlotte Wagner, Armin Kurtz
      Abstract: Genetic induction of hypoxia signaling by deletion of the von Hippel-Lindau (Vhl) protein in mesenchymal PDGFR-β+ cells leads to abundant HIF-2 dependent erythropoietin (EPO) expression in the cortex and outer medulla of the kidney. This rather unique feature of kidney PDGFR-β+ cells promote questions about their special characteristics and general functional response to hypoxia. To address these issues, we characterized kidney PDGFR-β+ EPO expressing cells based on additional cell markers and their gene expression profile in response to hypoxia signaling induced by targeted deletion of Vhl or exposure to low oxygen and carbon monoxide respectively, and after unilateral ureteral obstruction.
      Citation: Kidney International (2020)
      PubDate: 2020-05-22
      DOI: 10.1016/j.kint.2020.04.040
           IN RABBITS
    • Authors: Yusuke Sata; Sandra L. Burke, Anna M.D. Watson, Jay C. Jha, Cindy Gueguen, Nina Eikelis, Kyungjoon Lim, Kristy L. Jackson, Gavin W. Lambert, Karin A.M. Jandeleit-Dahm, Kate M. Denton, Murray D. Esler, Markus P. Schlaich, Geoffrey A. Head
      Abstract: Chronic kidney disease (CKD) is associated with greater sympathetic nerve activity but it is unclear if this is a kidney specific response or due to generalized stimulation of sympathetic nervous system activity. To determine this, we used a rabbit model of CKD in which quantitative comparisons with control rabbits could be made of kidney sympathetic nerve activity and whole-body norepinephrine spillover. Rabbits either had surgery to lesion 5/6th of the cortex of one kidney by electro-lesioning and two weeks later removal of the contralateral kidney, or sham lesioning and sham nephrectomy.
      Citation: Kidney International (2020)
      PubDate: 2020-04-25
      DOI: 10.1016/j.kint.2020.03.039
  • Early T cell infiltration is modulated by programed cell death-1 protein
           and its ligand (PD-1/PD-L1) interactions in murine kidney transplants.
    • Authors: Young Jun Shim; Raneem Khedraki, Jayeeta Dhar, Ran Fan, Nina Dvorina, Anna Valujskikh, Robert L. Fairchild, William M. Baldwin
      Abstract: Allogeneic transplants elicit dynamic T cell responses that are modulated by positive and negative co-stimulatory receptors. Understanding mechanisms that intrinsically modulate the immune responses to transplants is vital to develop rational treatment for rejection. Here, we have investigated the impact of programed cell death-1 (PD-1) protein, a negative co-stimulatory receptor on the rejection of MHC incompatible kidney transplants in mice. T cells were found to rapidly infiltrate the kidneys of A/J mice transplanted to C57BL/6 mice which peaked at six days and decline by day 14.
      Citation: Kidney International (2020)
      PubDate: 2020-04-25
      DOI: 10.1016/j.kint.2020.03.037
  • Metacarpal bone mineral density by radiographic absorptiometry predicts
           fracture risk in patients undergoing maintenance hemodialysis
    • Authors: Yosuke Nakagawa; Hirotaka Komaba, Naoto Hamano, Takehiko Wada, Miho Hida, Takao Suga, Takatoshi Kakuta, Masafumi Fukagawa
      Abstract: The 2017 Kidney Disease: Improving Global Outcomes (KDIGO) guideline update suggests bone mineral density testing to assess fracture risk in patients with chronic kidney disease, but dual-energy X-ray absorptiometry is not available in most dialysis facilities. Radiographic absorptiometry is an inexpensive and quick method for evaluating bone mineral density. Therefore, we analyzed a historical cohort of 456 maintenance hemodialysis patients to determine whether metacarpal bone mineral density measured by digital image processing, a computer-assisted radiographic absorptiometry technique, predicts fracture risk.
      Citation: Kidney International ()
      PubDate: 2020-04-09
      DOI: 10.1016/j.kint.2020.02.035
  • Establishing core outcome domains in pediatric kidney disease: report of
           the Standardized Outcomes in Nephrology – Children and Adolescents
           (SONG-KIDS) consensus workshops
    • Authors: Camilla S. Hanson; Jonathan C. Craig, Charlotte Logeman, Aditi Sinha, Allison Dart, Allison A. Eddy, Chandana Guha, Debbie S. Gipson, Detlef Bockenhauer, Hui-Kim Yap, Jaap Groothoff, Michael Zappitelli, Nicholas J.A. Webb, Stephen I. Alexander, Susan L. Furth, Susan Samuel, Alicia Neu, Andrea K. Viecelli, Angela Ju, Ankit Sharma, Eric H. Au, Hailey Desmond, Jenny I. Shen, Karine E. Manera, Karolis Azukaitis, Louese Dunn, Simon A. Carter, Talia Gutman, Yeoungjee Cho, Amanda Walker, Anna Francis, Cheryl Sanchez-Kazi, Joshua Kausman, Meghan Pearl, Nadine Benador, Shobha Sahney, Allison Tong
      First page: 553
      Abstract: Trials in children with chronic kidney disease (CKD) do not consistently report outcomes that are critically important to patients and caregivers. This can diminish the relevance and reliability of evidence for decision-making, limiting the implementation of results into practice and policy. As part of the Standardized Outcomes in Nephrology – Children and Adolescents (SONG-Kids) initiative, we convened two consensus workshops in San Diego, United States (7 patients, 24 caregivers, 43 health professionals; and Melbourne, Australia (7 patients, 23 caregivers, 49 health professionals).
      Citation: Kidney International (2020)
      PubDate: 2020-07-03
      DOI: 10.1016/j.kint.2020.05.054
  • International perspectives on Patient Involvement in Clinical Trials in
    • Authors: Debasish Banerjee; Racquel Lowe-Jones, Sandrine Damster, Nicola Thomas, Nicole Scholes-Robertson, Allison Tong, Adeera Levin, ISN-ACT patient-engagement in clinical trials group
      First page: 566
      Abstract: The involvement of patients in nephrology clinical trials is limited despite their ability to prioritise research, help with study design, participation and implementation of results. The aim of this position paper is to review the need, challenges and assess the present situation of patient involvement; and describe the role of International Society of Nephrology in promoting patient involvement.Patient involvement across from priority setting through to implementation of the trial findings can ensure that the evidence generated aligns with their priorities, maximises recruitment and retention, as well as its impact on practice and policy.
      Citation: Kidney International (2020)
      PubDate: 2020-07-09
      DOI: 10.1016/j.kint.2020.06.023
  • Novel trial strategies to enhance the relevance, efficiency, effectiveness
           and impact of nephrology research
    • Authors: Kathryn Dansie; Andrea K. Viecelli, Elaine M. Pascoe, David W. Johnson, Stephen McDonald, Philip Clayton, Carmel Hawley
      First page: 572
      Abstract: Randomised Controlled Trials (RCTs) are considered the gold-standard for evaluating the effectiveness of interventions. However, criticisms of traditional designs are that they can be inefficient, inflexible, expensive and conducted in a manner disconnected from real-life clinical practice. Novel strategies and approaches are being utilised to overcome these limitations including comprehensive consumer engagement, core outcome sets, novel trial designs, streamlined data collection, cost-effectiveness and return on investment evaluations, knowledge dissemination plans and impact evaluation.
      Citation: Kidney International (2020)
      PubDate: 2020-05-25
      DOI: 10.1016/j.kint.2020.04.050
  • The role of renal hypoxia in the pathogenesis of diabetic kidney disease:
           a promising target for newer renoprotective agents including SGLT2
    • Authors: Anne C. Hesp; Jennifer A. Schaub, Pottumarthi V. Prasad, Volker Vallon, Gozewijn D. Laverman, Petter Bjornstad, Daniël H. van Raalte
      First page: 579
      Abstract: Diabetic kidney disease is the most common cause of end-stage kidney disease and poses a major global health problem. Finding new, safe, and effective strategies to halt this disease has proven to be challenging. In part that is because the underlying mechanisms are complex and not fully understood. However, in recent years evidence has accumulated suggesting that chronic hypoxia may be the primary pathophysiological pathway driving diabetic kidney disease, and chronic kidney disease of other etiologies, and was coined the ‘chronic hypoxia hypothesis’.
      Citation: Kidney International (2020)
      PubDate: 2020-04-26
      DOI: 10.1016/j.kint.2020.02.041
  • Genetic Testing for Kidney Disease of Unknown Etiology
    • Authors: Thomas Hays; Emily E. Groopman, Ali G. Gharavi
      First page: 590
      Abstract: In many cases of CKD, the cause of disease remains unknown despite a thorough nephrological workup. Genetic testing has revolutionized many areas of medicine, and promises to empower diagnosis and targeted management of such cases of kidney disease of unknown etiology. Recent studies using genetic testing have demonstrated that Mendelian etiologies account for approximately 20% of cases of kidney disease of unknown etiology. While genetic testing has significant benefits, including tailoring of therapy, informing targeted workup, detecting extrarenal disease, counseling patients and families, and redirecting care, it also has important limitations and risks that must be considered.
      Citation: Kidney International (2020)
      PubDate: 2020-04-24
      DOI: 10.1016/j.kint.2020.03.031
  • Podocyte and endothelial-specific elimination of BAMBI identifies
           differential transforming growth factor-β pathways contributing to
           diabetic glomerulopathy.
    • Authors: Han Lai; Anqun Chen, Hong Cai, Jia Fu, Fadi Salem, Yu Li, John C. He, Detlef Schlondorff, Kyung Lee
      First page: 601
      Abstract: Transforming growth factor-β (TGF-β) is a central mediator of diabetic nephropathy. The effect of TGF-β, mediated by the type I TGF-β receptor, ALK5, and subsequent Smad2/3 activation results in podocyte apoptosis and loss. Previously, we demonstrated that the genetic deletion of the BMP and Activin Membrane-Bound Inhibitor (BAMBI), a negative modulator TGF-β signaling, accelerates diabetic nephropathy in mice. This was associated with heightened ALK1-mediated activation of Smad1/5 in the glomerular endothelial cells (ECs).
      Citation: Kidney International (2020)
      PubDate: 2020-04-26
      DOI: 10.1016/j.kint.2020.03.036
  • Interleukin-9 protects from early podocyte injury and progressive
           glomerulosclerosis in Adriamycin-induced nephropathy.
    • Authors: Tingting Xiong; Madena Attar, Ann-Christin Gnirck, Malte Wunderlich, Martina Becker, Constantin Rickassel, Victor G. Puelles, Catherine Meyer-Schwesinger, Thorsten Wiech, Jasper F. Nies, Mylène Divivier, Tobias Fuchs, Julian Schulze zur Wiesch, Hanna Taipaleenmäki, Elion Hoxha, Stefan Wirtz, Tobias B. Huber, Ulf Panzer, Jan-Eric Turner
      First page: 615
      Abstract: A wide spectrum of immunological functions has been attributed to Interleukin 9 (IL-9), including effects on the survival and proliferation of immune and parenchymal cells. In; recent years, emerging evidence suggests that IL-9 expression can promote tissue repair in; inflammatory conditions. However, data about the involvement of IL-9 in kidney tissueprotection is very limited. Here, we investigated the role of IL-9 in Adriamycin-induced nephropathy (AN), a mouse model for proteinuric chronic kidney disease.
      Citation: Kidney International (2020)
      PubDate: 2020-05-21
      DOI: 10.1016/j.kint.2020.04.036
    • Authors: Leon J. DeLalio; Ester Masati, Suresh Mendu, Claire A. Ruddiman, Yang Yang, Scott R. Johnstone, Jenna A. Milstein, T.C. Stevenson Keller, Rachel B. Weaver, Nick A. Guagliardo, Angela K. Best, Kodi S. Ravichandran, Douglas A. Bayliss, Maria Luisa S. Sequeira-Lopez, Swapnil N. Sonkusare, Xiaohong H. Shu, Bimal Desai, Paula Q. Barrett, Thu H. Le, R. Ariel Gomez, Brant E. Isakson
      First page: 630
      Abstract: Kidney function and blood pressure homeostasis are regulated by purinergic signaling mechanisms. These autocrine/paracrine signaling pathways are initiated by the release; of cellular ATP, which influences kidney hemodynamics and steady-state renin secretion; from juxtaglomerular cells. However, the mechanism responsible for ATP release that supports tonic inputs to juxtaglomerular cells and regulates renin secretion remains unclear. Pannexin 1 (Panx1) channels localize to both afferent arterioles and juxtaglomerular cells, and provide a transmembrane conduit for ATP release and ion permeability in the kidney and the vasculature.
      Citation: Kidney International (2020)
      PubDate: 2020-05-21
      DOI: 10.1016/j.kint.2020.04.041
  • Decoy receptor 2 mediation of the senescent phenotype of tubular cells by
           interacting with peroxiredoxin 1 presents a novel mechanism of renal
           fibrosis in diabetic nephropathy.
    • Authors: Chen Jia; Chen Ke-Hong, Xiao Fei, Dai Huan-Zi, Yang Jie, Wang Li-Ming, Wang Xiao-Yue, Zhang Jian-Guo, He Ya-Ni
      First page: 645
      Abstract: Premature senescence of renal tubular epithelial cell (RTEC), which is involved in kidney fibrosis, is a key event in the progression of diabetic nephropathy. However, the underlying mechanism remains unclear. Here we investigated the role and mechanism of decoy receptor 2 (DcR2) in kidney fibrosis and the senescent phenotype of RTEC. DcR2 was specifically expressed in senescent RTEC and associated with kidney fibrosis in patients with diabetic nephropathy and mice with streptozotocin-induced with diabetic nephropathy.
      Citation: Kidney International (2020)
      PubDate: 2020-04-24
      DOI: 10.1016/j.kint.2020.03.026
  • Accumulation of natriuretic peptides is associated with protein energy
           wasting and activation of browning in white adipose tissue in chronic
           kidney disease.
    • Authors: Mathilde Luce; Christophe Barba, Dan Yi, Anne Mey, Damien Roussel, Emilie Bres, Bérengère Benoit, Myriam Pastural, Samuel Granjon, Jean Christophe Szelag, Maurice Laville, Walid Arkouche, Anais Bouchara, Elsa Nyam, Denis Fouque, Christophe O. Soulage, Laetitia Koppe
      First page: 663
      Abstract: Protein energy wasting is a common feature of patients with chronic kidney disease (CKD) and is associated with poor outcomes. Protein energy wasting and cachexia, a severe form of protein energy wasting, are characterized by increased resting energy expenditure but the underlying mechanisms are unclear. Browning corresponds to the activation of inducible brown adipocytes in white adipose tissue and occurs in states of cachexia associated with hypermetabolic disease such as cancer. Here we tested the hypothesis that CKD-associated protein energy wasting could result from browning activation as a direct effect of the uremic environment on adipocytes.
      Citation: Kidney International (2020)
      PubDate: 2020-04-23
      DOI: 10.1016/j.kint.2020.03.027
  • Arginase 2 is a mediator of ischemia–reperfusion injury in the kidney
           through regulation of nitrosative stress
    • Authors: Masatoshi Hara; Kumiko Torisu, Keigo Tomita, Yasuhiro Kawai, Kazuhiko Tsuruya, Toshiaki Nakano, Takanari Kitazono
      First page: 673
      Abstract: Kidney ischemia–reperfusion injury is a major cause of acute kidney injury (AKI). Following reduced kidney perfusion, the pathological overproduction of reactive oxygen and reactive nitrogen species play a substantial role in the development of kidney ischemia–reperfusion injury. Arginase 2 (ARG2) competes with nitric oxide synthase for the same substrate, L-arginine, and is implicated in the regulation of reactive nitrogen species. Therefore, we investigated the role of ARG2 in kidney ischemia–reperfusion injury using human proximal tubule cells (HK-2) and a mouse model of kidney ischemia–reperfusion injury.
      Citation: Kidney International (2020)
      PubDate: 2020-04-24
      DOI: 10.1016/j.kint.2020.03.032
  • Tuberous sclerosis 1(Tsc1) mediated mTORC1 activation promotes glycolysis
           in tubular epithelial cells in kidney fibrosis.
    • Authors: Hongdi Cao; Jing Luo, Yu Zhang, Xiaoming Mao, Ping Wen, Hao Ding, Jing Xu, Qi Sun, Weichun He, Chunsun Dai, Ke Zen, Yang Zhou, Junwei Yang, Lei Jiang
      First page: 686
      Abstract: Energy reprogramming to glycolysis is closely associated with the development of chronic kidney disease. As an important negative regulatory factor of the mammalian target of rapamycin complex 1 (mTORC1) signal, tuberous sclerosis complex 1 (Tsc1) is also a key regulatory point of glycolysis. Here, we investigated whether Tsc1 could mediate the progression of kidney interstitial fibrosis by regulating glycolysis in proximal tubular epithelial cells. We induced mTORC1 signal activation in tubular epithelial cells in kidneys with fibrosis via unilateral ureteral occlusion.
      Citation: Kidney International (2020)
      PubDate: 2020-04-27
      DOI: 10.1016/j.kint.2020.03.035
  • Podocyte stress and detachment measured in urine is related to mean
           arterial pressure in healthy humans
    • Authors: Abhijit S. Naik; Dustin Le, Jawad Aqeel, Su Q. Wang, Mahboob Chowdhury, Lisa M. Walters, Diane M. Cibrik, Milagros Samaniego, Roger C. Wiggins
      First page: 699
      Abstract: Hypertension-associated progressive glomerulosclerosis is a significant driver of both de novo and all-cause chronic kidney disease leading to end-stage kidney failure. The progression of glomerular disease proceeds via continuing depletion of podocytes from the glomeruli into the; ultrafiltrate. To non-invasively assess injury patterns associated with mean arterial pressure (MAP), we conducted an observational study of 87 healthy normotensive individuals who were cleared for living kidney donation.
      Citation: Kidney International (2020)
      PubDate: 2020-04-27
      DOI: 10.1016/j.kint.2020.03.038
  • A bidirectional Mendelian randomization study supports causal effects of
           kidney function on blood pressure.
    • Authors: Zhi Yu; Josef Coresh, Guanghao Qi, Morgan Grams, Eric Boerwinkle, Harold Snieder, Alexander Teumer, Cristian Pattaro, Anna Köttgen, Nilanjan Chatterjee, Adrienne Tin
      First page: 708
      Abstract: Blood pressure and kidney function have a bidirectional relation. Hypertension has long been considered as a risk factor for kidney function decline. However, whether intensive blood; pressure control could promote kidney health has been uncertain. The kidney is known to have a; major role in affecting blood pressure through sodium extraction and regulating electrolyte balance. This bidirectional relation makes causal inference between these two traits difficult. Therefore, to examine the causal relations between these two traits, we performed two-sample Mendelian randomization analyses using summary statistics of large-scale genome-wide association studies.
      Citation: Kidney International (2020)
      PubDate: 2020-05-22
      DOI: 10.1016/j.kint.2020.04.044
  • Clinical and Genetic Spectra of Autosomal Dominant Tubulointerstitial
           Kidney Disease due to Mutations in UMOD and MUC1
    • Authors: E. Olinger; P. Hofmann, K. Kidd, I. Dufour, H. Belge, C. Schaeffer, A. Kipp, O. Bonny, C. Deltas, N. Demoulin, T. Fehr, D.G. Fuster, D.P. Gale, E. Goffin, K. Hodanova, U. Hyunh-Do, A.D. Kistler, J. Morelle, G. Papagregoriou, Y. Pirson, R. Sandford, J.A. Sayer, R. Torra, C. Venzin, R. Venzin, B. Vogt, M. Živná, A. Greka, K. Dahan, L. Rampoldi, S. Kmoch, A.J. Bleyer, O. Devuyst
      First page: 717
      Abstract: Autosomal dominant tubulointerstitial kidney disease (ADTKD) is an increasingly recognized. cause of end-stage kidney disease, primarily due to mutations in UMOD and MUC1. The lack of clinical recognition and the small size of cohorts have slowed the understanding of disease ontology and development of diagnostic algorithms. To expand on this, we analyzed two registries from Europe and the United States to define genetic and clinical characteristics of ADTKD-UMOD and ADTKD-MUC1 and develop a practical score to guide genetic testing.
      Citation: Kidney International (2020)
      PubDate: 2020-05-21
      DOI: 10.1016/j.kint.2020.04.038
  • Imbalance favoring follicular helper T cells over IL10+ regulatory B cells
           is detrimental for the kidney allograft
    • Authors: Rocio Laguna-Goya; Alberto Utrero-Rico, Francisco Luis Cano-Romero, Elena Gómez-Massa, Esther González, Amado Andrés, Esther Mancebo-Sierra, Estela Paz-Artal
      First page: 732
      Abstract: A high frequency of regulatory B (Breg) cells, generally transitional B cells, has been associated with long-term kidney allograft survival and operational tolerance. However, circulating follicular helper T cells (cTfh) correlate with graft rejection. In order to better understand the interplay between these cell subsets and to determine their association with graft outcome we studied transitional and IL10+ Breg cells, as well as cTfh, pre- and post-transplantation in a prospective cohort of 200 kidney transplant recipients and in healthy volunteers,.
      Citation: Kidney International (2020)
      PubDate: 2020-04-20
      DOI: 10.1016/j.kint.2020.02.039
  • ANCA autoantigen gene expression highlights neutrophil heterogeneity where
           expression in normal-density neutrophils correlates with ANCA-induced
    • Authors: Britta E. Jones; Carolina A. Herrera, Christian Agosto-Burgos, Joshua Starmer, William A. Bass, Caroline J. Poulton, Lauren Blazek, Candace D. Henderson, Yichun Hu, Susan L. Hogan, Peiqi Hu, Hong Xiao, Eveline Y. Wu, Dhruti P. Chen, J. Charles Jennette, Meghan E. Free, Ronald J. Falk, Dominic J. Ciavatta
      First page: 744
      Abstract: ANCA vasculitis is an autoimmune disease with increased expression of the autoantigen genes, myeloperoxidase (MPO) and proteinase 3 (PRTN3), but their origin and significance of expression is less distinct. To clarify this, we measured MPO and PRTN3 messenger RNA in monocytes, normal-density neutrophils, and in enriched leukocytes from peripheral blood mononuclear cells. Increased autoantigen gene expression was detected in normal-density neutrophils and enriched leukocytes from patients during active disease compared to healthy individuals, with the largest difference in enriched leukocytes.
      Citation: Kidney International (2020)
      PubDate: 2020-05-21
      DOI: 10.1016/j.kint.2020.04.037
  • Genome-wide non-HLA donor-recipient genetic differences influence renal
           allograft survival via early allograft fibrosis
    • Authors: Zhongyang Zhang; Madhav C. Menon, Weijia Zhang, Eli Stahl, Bao-Li Loza, Ivy A. Rosales, Zhengzi Yi, Khadija Banu, Felipe Garzon, Zeguo Sun, Chengguo Wei, Weiqing Huang, Qisheng Lin, Ajay Israni, Brendan J. Keating, Robert B. Colvin, Ke Hao, Barbara Murphy
      First page: 758
      Abstract: Donor-recipient (D-R) differences at human leukocyte antigen (HLA) loci are currently incorporated into organ sharing, allocation and immunosuppression decisions. However, while acute rejection episodes have substantially diminished, progressive histologic damage occurs in allografts and improved long-term survival remains an unrealized goal among kidney recipients. Here we tested the hypothesis that non-HLA dependent, genome-wide D-R genetic differences.could contribute to unchecked alloimmunity with histologic and functional consequences, culminating in long-term allograft failure.
      Citation: Kidney International (2020)
      PubDate: 2020-05-23
      DOI: 10.1016/j.kint.2020.04.039
  • Mediators of the effects of canagliflozin on kidney protection in patients
           with type 2 diabetes
    • Authors: JingWei Li; Bruce Neal, Vlado Perkovic, Dick de Zeeuw, Brendon L. Neuen, Clare Arnott, Roger Simpson, Richard Oh, Kenneth W. Mahaffey, Hiddo J.L. Heerspink
      First page: 769
      Abstract: Canagliflozin reduced kidney disease progression in participants with type 2 diabetes in the CANagliflozin cardioVascular Assessment Study (CANVAS) Program that explored potential mediators of the effects of canagliflozin on kidney outcomes. The percent mediating effect of 18 biomarkers indicative of disease was determined by comparing the hazard ratios for the effect of randomized treatment from an unadjusted model and from a model adjusting for the average post-randomization level of each biomarker.
      Citation: Kidney International (2020)
      PubDate: 2020-05-27
      DOI: 10.1016/j.kint.2020.04.051
  • Reduced prescription tacrolimus use: A cross-sectional analysis of
           England’s national prescription statistics during COVID-19 pandemic by
    • Authors: Ravina Barrett
      First page: 778
      Abstract: Many United Kingdom transplant centres currently provide restricted access due to COVID-19.1. Full-year total organ transplants were 3997 in 2019/20 versus 4183 in the previous year, a fall of 4.45% as shown in table 1.
      Citation: Kidney International (2020)
      PubDate: 2020-06-25
      DOI: 10.1016/j.kint.2020.06.010
  • Anti-glomerular basement membrane disease during the COVID-19 pandemic
    • Authors: Maria Prendecki; Candice Clarke, Tom Cairns, Terry Cook, Candice Roufosse, David Thomas, Michelle Willicombe, Charles D. Pusey, Stephen P. McAdoo
      First page: 780
      Abstract: Anti-glomerular basement membrane (anti-GBM) disease is a rare autoimmune small vessel vasculitis.1 The recent confirmation of spatial and temporal clustering of cases suggests that environmental factors, including infection, may trigger disease in susceptible individuals.2
      Citation: Kidney International (2020)
      PubDate: 2020-06-26
      DOI: 10.1016/j.kint.2020.06.009
  • Coronavirus Disease (COVID-19) hospitalized patients with acute kidney
           injury (AKI) treated with acute peritoneal dialysis do not have infectious
           PD effluent
    • Authors: Osama El Shamy; Joseph A. Vassalotti, Shuchita Sharma, Teresa Aydillo-Gomez, Nada Marjanovic, Irene Ramos, Adolfo García-Sastre, Jaime Uribarri
      First page: 782
      Abstract: Acute peritoneal dialysis (PD) has been used in COVID-19 as an alternative to intermittent hemodialysis or continuous renal replacement therapy to mitigate the overwhelming demand for dialysis1,2. Liters of PD effluent are discarded in the sewerage system by both patients and medical institutions performing PD on a daily basis. The detection of SARS-CoV-2 in the peritoneal waste of a COVID-19 infected patient with end stage kidney disease was previously reported3. Given the uncertainty regarding the risk for viral transmission through the handling of PD effluent of patients with confirmed COVID-19 infections, we set out to determine the presence and infectivity of the SARS-CoV-2 virus in the PD effluent of 10 admitted patients with severe COVID-19 pneumonia (Table 1) treated with acute PD.
      Citation: Kidney International (2020)
      PubDate: 2020-06-23
      DOI: 10.1016/j.kint.2020.06.012
  • “Dysmorphic” lysosomes in proximal tubular cells are not specific for
           CINAC/CKDu and do not provide evidence that CINAC/CKDu is a toxin-induced
    • Authors: Julia Wijkström; Carl-Gustaf Elinder, Kjell Hultenby, Magnus Söderberg, Annika Wernerson
      First page: 786
      Abstract: In a recent report, Vervaet and collaborators argue that chronic interstitial nephritis in agricultural communities (CINAC)/chronic kidney disease of unknow cause (CKDu) is a toxin-induced nephropathy with “dysmorphic” lysosomes in proximal tubular cells (PTCs), and they present diagnostic criteria for this lysosomal phenotype.1
      Citation: Kidney International (2020)
      PubDate: 2020-06-17
      DOI: 10.1016/j.kint.2020.04.057
  • Response to “Dysmorphic” lysosomes in proximal tubular cells are not
           specific for CINAC/CKDu and do not provide evidence that CINAC/CKDu is a
           toxin-induced disease
    • Authors: Benjamin A. Vervaet; Cynthia C. Nast, Gerd Schreurs, Channa Jayasumana, Chula Herath, Marc E. De Broe
      First page: 787
      Abstract: We took notice of the comments raised by Wijkström et al.1 on our manuscript2. Since it was impossible to properly answer 8 issues within the size limitations of this letter, we extended our response with a Supplemental file.
      Citation: Kidney International (2020)
      PubDate: 2020-07-02
      DOI: 10.1016/j.kint.2020.06.021
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