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    - UROLOGY, NEPHROLOGY AND ANDROLOGY (155 journals)

UROLOGY, NEPHROLOGY AND ANDROLOGY (155 journals)                     

Showing 1 - 156 of 156 Journals sorted alphabetically
Acta Urológica Portuguesa     Open Access   (Followers: 1)
Actas Urológicas Españolas     Full-text available via subscription   (Followers: 3)
Actas Urológicas Españolas (English Edition)     Full-text available via subscription   (Followers: 1)
Advances in Chronic Kidney Disease     Full-text available via subscription   (Followers: 11)
Advances in Urology     Open Access   (Followers: 13)
African Journal of Nephrology     Open Access  
African Journal of Urology     Open Access   (Followers: 7)
AJP Renal Physiology     Hybrid Journal   (Followers: 8)
Aktuelle Urologie     Hybrid Journal   (Followers: 4)
American Journal of Kidney Diseases     Hybrid Journal   (Followers: 43)
American Journal of Men's Health     Open Access   (Followers: 9)
American Journal of Nephrology     Full-text available via subscription   (Followers: 37)
Andrologia     Hybrid Journal   (Followers: 2)
Andrology     Hybrid Journal   (Followers: 4)
Andrology & Gynecology : Current Research     Hybrid Journal   (Followers: 4)
Andrology and Genital Surgery     Open Access   (Followers: 7)
Andrology-Open Access     Open Access  
Annales d'Urologie     Full-text available via subscription  
Arab Journal of Nephrology and Transplantation     Open Access   (Followers: 1)
Arab Journal of Urology     Open Access   (Followers: 7)
Archives of Clinical Nephrology     Open Access   (Followers: 2)
Archivio Italiano di Urologia e Andrologia     Open Access   (Followers: 1)
Archivos Españoles de Urología     Open Access  
Asian Journal of Andrology     Open Access   (Followers: 1)
Asian Journal of Urology     Open Access   (Followers: 3)
Bangladesh Journal of Urology     Open Access   (Followers: 5)
BANTAO Journal     Open Access  
Basic and Clinical Andrology     Open Access  
BJU International     Hybrid Journal   (Followers: 34)
BMC Nephrology     Open Access   (Followers: 10)
BMC Urology     Open Access   (Followers: 14)
Canadian Journal of Kidney Health and Disease     Open Access   (Followers: 7)
Canadian Urological Association Journal     Open Access   (Followers: 2)
Cancer Urology     Open Access   (Followers: 2)
Cardiorenal Medicine     Full-text available via subscription   (Followers: 1)
Case Reports in Nephrology     Open Access   (Followers: 5)
Case Reports in Nephrology and Dialysis     Open Access   (Followers: 9)
Case Reports in Urology     Open Access   (Followers: 12)
Clinical and Experimental Nephrology     Hybrid Journal   (Followers: 4)
Clinical Journal of the American Society of Nephrology     Full-text available via subscription   (Followers: 20)
Clinical Kidney Journal     Open Access   (Followers: 4)
Clinical Medicine Insights : Urology     Open Access   (Followers: 3)
Clinical Nephrology     Full-text available via subscription   (Followers: 8)
Clinical Nephrology and Urology Science     Open Access   (Followers: 6)
Clinical Queries: Nephrology     Hybrid Journal   (Followers: 1)
Cuadernos de Cirugía     Open Access   (Followers: 3)
Current Opinion in Nephrology & Hypertension     Hybrid Journal   (Followers: 10)
Current Opinion in Urology     Hybrid Journal   (Followers: 12)
Current Urology     Open Access   (Followers: 10)
Current Urology Reports     Hybrid Journal   (Followers: 5)
Der Nephrologe     Hybrid Journal  
Der Urologe     Hybrid Journal   (Followers: 1)
EMC - Urología     Full-text available via subscription  
Enfermería Nefrológica     Open Access   (Followers: 1)
European Urology     Full-text available via subscription   (Followers: 34)
European Urology Focus     Hybrid Journal   (Followers: 4)
European Urology Supplements     Full-text available via subscription   (Followers: 10)
Forum Nefrologiczne     Full-text available via subscription  
Geriatric Nephrology and Urology     Hybrid Journal   (Followers: 7)
Giornale di Clinica Nefrologica e Dialisi     Open Access  
Herald Urology     Open Access   (Followers: 2)
Hong Kong Journal of Nephrology     Open Access   (Followers: 3)
Human Andrology     Partially Free   (Followers: 2)
IJU Case Reports     Open Access  
Indian Journal of Nephrology     Open Access   (Followers: 2)
Indian Journal of Urology     Open Access   (Followers: 5)
International Brazilian Journal of Urology     Open Access   (Followers: 5)
International Journal of Nephrology     Open Access   (Followers: 2)
International Journal of Nephrology and Renovascular Disease     Open Access   (Followers: 2)
International Journal of Urology     Hybrid Journal   (Followers: 12)
International Urology and Nephrology     Hybrid Journal   (Followers: 7)
Jornal Brasileiro de Nefrologia     Open Access  
Journal für Urologie und Urogynäkologie/Österreich     Hybrid Journal  
Journal of Clinical Nephrology     Open Access   (Followers: 1)
Journal of Clinical Urology     Hybrid Journal   (Followers: 14)
Journal of Endoluminal Endourology     Open Access  
Journal of Endourology     Hybrid Journal   (Followers: 2)
Journal of Endourology Case Reports     Hybrid Journal  
Journal of Genital System & Disorders     Hybrid Journal   (Followers: 3)
Journal of Integrative Nephrology and Andrology     Open Access   (Followers: 2)
Journal of Kidney Cancer and VHL     Open Access  
Journal of Lower Genital Tract Disease     Hybrid Journal  
Journal of Nephrology     Hybrid Journal   (Followers: 4)
Journal of Nephrology Research     Open Access   (Followers: 3)
Journal of Pediatric Nephrology     Open Access   (Followers: 4)
Journal of Renal Care     Hybrid Journal   (Followers: 8)
Journal of Renal Nursing     Full-text available via subscription   (Followers: 12)
Journal of Renal Nutrition     Hybrid Journal   (Followers: 28)
Journal of Renal Nutrition and Metabolism     Open Access   (Followers: 1)
Journal of the American Society of Nephrology     Full-text available via subscription   (Followers: 29)
Journal of The Egyptian Society of Nephrology and Transplantation     Open Access  
Journal of Translational Neurosciences     Open Access  
Journal of Urology     Full-text available via subscription   (Followers: 45)
Journal of Urology & Nephrology     Open Access   (Followers: 2)
Kidney Disease and Transplantation     Open Access   (Followers: 4)
Kidney Diseases     Open Access   (Followers: 3)
Kidney International     Hybrid Journal   (Followers: 46)
Kidney International Reports     Open Access   (Followers: 3)
Kidney Medicine     Open Access  
Kidney Research Journal     Open Access   (Followers: 6)
Kidneys (Počki)     Open Access   (Followers: 1)
Nature Reviews Nephrology     Full-text available via subscription   (Followers: 20)
Nature Reviews Urology     Full-text available via subscription   (Followers: 12)
Nefrología (English Edition)     Open Access  
Nefrología (Madrid)     Open Access  
Nephro-Urology Monthly     Open Access   (Followers: 1)
Nephrology     Hybrid Journal   (Followers: 13)
Nephrology Dialysis Transplantation     Hybrid Journal   (Followers: 26)
Nephron     Hybrid Journal   (Followers: 4)
Nephron Clinical Practice     Full-text available via subscription   (Followers: 4)
Nephron Experimental Nephrology     Full-text available via subscription   (Followers: 4)
Nephron Extra     Open Access   (Followers: 1)
Nephron Physiology     Full-text available via subscription   (Followers: 4)
Neurourology and Urodynamics     Hybrid Journal   (Followers: 1)
OA Nephrology     Open Access   (Followers: 2)
Open Access Journal of Urology     Open Access   (Followers: 6)
Open Journal of Nephrology     Open Access   (Followers: 5)
Open Journal of Urology     Open Access   (Followers: 6)
Open Urology & Nephrology Journal     Open Access  
Pediatric Urology Case Reports     Open Access   (Followers: 7)
Portuguese Journal of Nephrology & Hypertension     Open Access   (Followers: 1)
Progrès en Urologie     Full-text available via subscription  
Progrès en Urologie - FMC     Full-text available via subscription  
Prostate Cancer and Prostatic Diseases     Hybrid Journal   (Followers: 6)
Renal Failure     Open Access   (Followers: 12)
Renal Replacement Therapy     Open Access   (Followers: 4)
Research and Reports in Urology     Open Access   (Followers: 4)
Revista de Nefrología, Diálisis y Trasplante     Open Access   (Followers: 1)
Revista Mexicana de Urología     Open Access   (Followers: 1)
Revista Urologia Colombiana     Open Access  
Saudi Journal of Kidney Diseases and Transplantation     Open Access   (Followers: 2)
Scandinavian Journal of Urology     Hybrid Journal   (Followers: 7)
Seminars in Nephrology     Hybrid Journal   (Followers: 11)
The Prostate     Hybrid Journal   (Followers: 8)
Therapeutic Advances in Urology     Open Access   (Followers: 4)
Trends in Urology & Men's Health     Partially Free   (Followers: 1)
Ukrainian Journal of Nephrology and Dialysis     Open Access   (Followers: 1)
Uro-News     Hybrid Journal   (Followers: 1)
Urolithiasis     Hybrid Journal   (Followers: 2)
Urologia Internationalis     Full-text available via subscription   (Followers: 2)
Urologia Journal     Hybrid Journal  
Urologic Clinics of North America     Full-text available via subscription   (Followers: 4)
Urologic Nursing     Full-text available via subscription   (Followers: 4)
Urologic Radiology     Hybrid Journal  
Urological Science     Open Access  
Urologicheskie Vedomosti     Open Access  
Urologie in der Praxis     Hybrid Journal  
Urologie Scan     Hybrid Journal  
Urology     Hybrid Journal   (Followers: 33)
Urology Annals     Open Access   (Followers: 4)
Urology Case Reports     Open Access   (Followers: 3)
Urology Practice     Full-text available via subscription   (Followers: 2)
Urology Times     Free   (Followers: 3)
Urology Video Journal     Open Access   (Followers: 1)
World Journal of Nephrology and Urology     Open Access   (Followers: 15)
World Journal of Urology     Hybrid Journal   (Followers: 11)

           

Similar Journals
Journal Cover
Kidney International
Journal Prestige (SJR): 3.238
Citation Impact (citeScore): 5
Number of Followers: 46  
 
  Hybrid Journal Hybrid journal (It can contain Open Access articles)
ISSN (Print) 0085-2538 - ISSN (Online) 1523-1755
Published by NPG Homepage  [138 journals]
  • Subscription Information
    • Citation: Kidney International 98, 6 (2020)
      PubDate: 2020-12
      DOI: 10.1016/S0085-2538(20)31285-0
      Issue No: Vol. 98, No. 6 (2020)
       
  • In this issue—2020 draws to a close
    • Authors: Brad H. Rovin
      First page: 1361
      Abstract: As 2020 draws to a close, our last issue of Kidney International for this year is focused on the consequences of the pandemic for patients receiving renal replacement therapy. We offer our readership 7 original manuscripts, 4 letters to the editor, 1 editorial, 1 review, and 2 commentaries for their consideration. These curated articles were chosen because they report on large populations that the editors felt provided more accurate estimates of incidence, prevalence and consequences of the disease.
      Citation: Kidney International 98, 6 (2020)
      PubDate: 2020-12
      Issue No: Vol. 98, No. 6 (2020)
       
  • Sixty (plus one) breakthrough discoveries in nephrology
    • Authors: Yosuke Hirakawa; Masaomi Nangaku, Vivekanand Jha, Adeera Levin
      Pages: 1362 - 1366
      Abstract: To celebrate the 60th Anniversary of the International Society of Nephrology (ISN), Kidney International published a series of “Milestones in Nephrology.”1 For the same purpose, the ISN Research Working Group, supported by the ISN Young Nephrologist Committee, published narratives highlighting 60 + 1 historical discoveries of significant impact to the nephrology community (Supplementary Table S1). So that the selection of discoveries was globally representative, the leadership of the 10 ISN Regional Boards was asked to provide references from their respective regions (Supplementary References).
      Citation: Kidney International 98, 6 (2020)
      PubDate: 2020-12
      DOI: 10.1016/j.kint.2020.09.019
      Issue No: Vol. 98, No. 6 (2020)
       
  • The Nobel Prize in chemistry in 2020: genome editing tools and their
           immeasurable applications for humankind
    • Authors: Yoshiki Higashijima; Masaomi Nangaku
      Pages: 1367 - 1369
      Abstract: This year’s Nobel Prize in Chemistry was awarded to 2 remarkable researchers—Emmanuelle Charpentier from France now at the Max Planck Unit for the Science of Pathogens (Berlin, Germany) and Jennifer Doudna from University of California, Berkeley , who is also an investigator at Howard Hughes Medical Institute (San Francisco, CA)—who have developed one of the most flexible and precise genetic scissors, the CRISPR-Cas9 system. At the time of the discovery, Emmanuelle Charpentier was studying the gene regulatory mechanisms of pathogenic bacteria to understand how they can acquire resistance to antibiotics and viruses (phages), with the aim to find new therapeutic targets of infectious diseases, while Jennifer Doudna was leading the RNA structural biology field from the early 2000s.
      Citation: Kidney International 98, 6 (2020)
      PubDate: 2020-12
      Issue No: Vol. 98, No. 6 (2020)
       
  • Epidemiology of kidney disease: consolidating and integrating the evidence
           to improve kidney care from early childhood to adulthood
    • Authors: Germaine Wong; Toby Coates
      Pages: 1378 - 1381
      Abstract: Since the birth of Kidney International more than 60 years ago, the journal has unyieldingly challenged and questioned the evidence that underpins the epidemiology of kidney disease and its long-term outcomes at a global level. The publications highlighted here have improved our understanding of intrauterine programming on organ function and disease later in adult lives; the impact of low birth weight, nephron mass, kidney disease, and hypertension; the epidemiology of acute kidney injury (AKI) at a population level; and factors associated with adverse outcomes in those with kidney failure.
      Citation: Kidney International 98, 6 (2020)
      PubDate: 2020-12
      DOI: 10.1016/j.kint.2020.09.020
      Issue No: Vol. 98, No. 6 (2020)
       
  • Journal Club
    • Pages: 1382 - 1384
      Abstract: Groop et al. (Lancet Diabetes Endocrinol. 2020;8:845–854.)
      Citation: Kidney International 98, 6 (2020)
      PubDate: 2020-12
      Issue No: Vol. 98, No. 6 (2020)
       
  • Podocyte healthy self-eating boosted by a spermidine meal'
    • Authors: Olivia Lenoir; Pierre-Louis Tharaux
      Pages: 1390 - 1392
      Abstract: The mechanisms sustaining a high level of autophagy in podocytes are not well delineated. Seminal studies had unraveled that the polyamine pathway is involved in the regulation of aging and autophagy. Polyamines (e.g., spermine, spermidine, and putrescine) are ubiquitous molecules essential for the physiological processes, including cell growth, development, and differentiation. Liang et al. examined the role of ornithine decarboxylase, and spermidine synthase, and demonstrated that endogenous spermidine is required to maintain intact podocyte autophagy.
      Citation: Kidney International 98, 6 (2020)
      PubDate: 2020-12
      DOI: 10.1016/j.kint.2020.07.032
      Issue No: Vol. 98, No. 6 (2020)
       
  • Kidney-derived PCSK9—a new driver of hyperlipidemia in nephrotic
           syndrome'
    • Authors: Ferruh Artunc
      Pages: 1393 - 1395
      Abstract: Increased plasma concentrations of proprotein convertase subtilisin/kexin type 9 or PCSK9, which reduces hepatic uptake of low-density lipoprotein by downregulation of the low-density lipoprotein receptor, have been reported in nephrotic patients and might contribute to hyperlipidemia in nephrotic syndrome. The results of the study by Molina-Jijon et al. found that renal PCSK9 expression was upregulated in the collecting duct of nephrotic patients and animals, suggesting that the kidney might be a major source for plasma PCSK9 in nephrotic syndrome.
      Citation: Kidney International 98, 6 (2020)
      PubDate: 2020-12
      DOI: 10.1016/j.kint.2020.07.027
      Issue No: Vol. 98, No. 6 (2020)
       
  • More than ever, efficient evaluation of potential living kidney donors is
           needed
    • Authors: Edward G. Clark; Greg Knoll
      Pages: 1395 - 1397
      Abstract: In this issue, Habbous et al. reported that simultaneously evaluating multiple potential living kidney donors for the same intended recipient, rather than sequentially, is more effective and less expensive. This important study highlighted how quicker living kidney donor evaluations benefit patients and lower costs by reducing time spent on dialysis. Given the backlog precipitated by the coronavirus disease 2019 pandemic, devoting resources to ensure efficient living kidney donor evaluations is a better investment than ever before.
      Citation: Kidney International 98, 6 (2020)
      PubDate: 2020-12
      DOI: 10.1016/j.kint.2020.07.020
      Issue No: Vol. 98, No. 6 (2020)
       
  • Clinical and genetic spectra of kidney disease caused by REN mutations
    • Authors: Céline Schaeffer; Eric Olinger
      Pages: 1397 - 1400
      Abstract: Heterozygous mutations in REN cause autosomal dominant tubulointerstitial kidney disease (ADTKD), an increasingly recognized entity characterized by interstitial fibrosis and tubular damage. In contrast to more common forms of ADTKD, the rarity of ADTKD-REN has precluded a thorough disease characterization. Živná and colleagues take advantage of an international patient cohort to expand the genetic and clinical spectra of ADTKD-REN and to establish genotype-phenotype correlations with important implications for patient care.
      Citation: Kidney International 98, 6 (2020)
      PubDate: 2020-12
      DOI: 10.1016/j.kint.2020.08.013
      Issue No: Vol. 98, No. 6 (2020)
       
  • Angiotensin-converting enzyme inhibitors in patients with Alport syndrome:
           can all patients benefit'
    • Authors: Michelle N. Rheault
      Pages: 1400 - 1402
      Abstract: Angiotensin-converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARBs) are prescribed to slow the progression of kidney disease in patients with Alport syndrome. In a recent publication by Yamamura et al. the authors showed an association of ACEi or ARB treatment with delay in ESKD, even for those patients with severe, truncating mutations. Despite these encouraging findings, there remain a number of clinical questions about the use of ACEi and ARBs in Alport syndrome.
      Citation: Kidney International 98, 6 (2020)
      PubDate: 2020-12
      DOI: 10.1016/j.kint.2020.07.011
      Issue No: Vol. 98, No. 6 (2020)
       
  • KDIGO Controversies Conference on onco-nephrology: kidney disease in
           hematological malignancies and the burden of cancer after kidney
           transplantation
    • Authors: Jolanta Małyszko; Aristotelis Bamias, Farhad R. Danesh, Alicja Dębska-Ślizień, Maurizio Gallieni, Morie A. Gertz, Jan T. Kielstein, Petra Tesarova, Germaine Wong, Michael Cheung, David C. Wheeler, Wolfgang C. Winkelmayer, Camillo Porta, Conference Participants
      Pages: 1407 - 1418
      Abstract: The bidirectional relationship between cancer and chronic kidney disease (CKD) is complex. Patients with cancer, particularly those with hematological malignancies such as multiple myeloma and lymphoma, are at increased risk of developing acute kidney injury and CKD. On the other hand, emerging evidence from large observational registry analyses have consistently shown that cancer risk is increased by at least 2- to 3-fold in kidney transplant recipients, and the observed increased risk occurs not only in those who have received kidney transplants but also in those on dialysis and with mild- to moderate-stage CKD.
      Citation: Kidney International 98, 6 (2020)
      PubDate: 2020-12
      DOI: 10.1016/j.kint.2020.07.012
      Issue No: Vol. 98, No. 6 (2020)
       
  • Executive summary for China Kidney Disease Network (CK-NET) 2016 Annual
           Data Report
    • Authors: Chao Yang; Bixia Gao, Xinju Zhao, Zaiming Su, Xiaoyu Sun, Huai-Yu Wang, Ping Zhang, Rong Wang, Jian Liu, Wen Tang, Dongliang Zhang, Hong Chu, Jinwei Wang, Fang Wang, Song Wang, Li Zuo, Yue Wang, Feng Yu, Haibo Wang, Luxia Zhang, Hong Zhang, Li Yang, Jianghua Chen, Ming-Hui Zhao
      Pages: 1419 - 1423
      Abstract: Chronic kidney disease (CKD) has been recognized as a public health problem globally. The spectrum of CKD in China has been evolving toward that of developed countries, which will have enormous impacts on the health care system. However, there has been no well-established national surveillance system for kidney diseases. Furthermore, China still faces several challenges of kidney care, including limited capacity and efficiency, suboptimal awareness, and huge heterogeneity in diagnosis and treatment.
      Citation: Kidney International 98, 6 (2020)
      PubDate: 2020-12
      DOI: 10.1016/j.kint.2020.09.003
      Issue No: Vol. 98, No. 6 (2020)
       
  • Erratum to “Rondeau E, Scully M, Ariceta G, Barbour T, Cataland S, Heyne
           N, Miyakawa Y, Ortiz S, Swenson E, Vallee M, Yoon S-S, Kavanagh D, Haller
           H; on behalf of the 311 Study Group. The long-acting C5 inhibitor,
           Ravulizumab, is effective and safe in adult patients with atypical
           hemolytic uremic syndrome naïve to complement inhibitor treatment”
           Kidney Int. 2020;97:1287–1296
    • Authors: Eric Rondeau; Marie Scully, Gema Ariceta, Tom Barbour, Spero Cataland, Nils Heyne, Yoshitaka Miyakawa, Stephan Ortiz, Eugene Swenson, Marc Vallee, Sung-Soo Yoon, David Kavanagh, Hermann Haller, 311 Study Group
      First page: 1621
      Abstract: The publisher regrets that the members of the 311 Study Group were not included as collaborative authors. Members of the 311 Study Group are listed in the Appendix.
      Citation: Kidney International 98, 6 (2020)
      PubDate: 2020-12
      DOI: 10.1016/j.kint.2020.11.001
      Issue No: Vol. 98, No. 6 (2020)
       
  • Corrigendum to “Gordon CE, Perrone RD. Tolvaptan or transplant: why
           wait'” Kidney Int. 2020;98:286–289
    • First page: 1622
      Abstract: The authors regret that disclosures were inadvertently not included with the published article.
      Citation: Kidney International 98, 6 (2020)
      PubDate: 2020-12
      DOI: 10.1016/j.kint.2020.11.002
      Issue No: Vol. 98, No. 6 (2020)
       
  • Cell invasion in glomerular basement membrane: infolding glomerulopathy
    • Authors: Shun Manabe; Masayo Sato, Hiroshi Kataoka, Sekiko Taneda, Toshio Mochizuki, Kosaku Nitta
      First page: 1623
      Abstract: We describe the case of a 35-year-old woman with Sjogren’s syndrome and scleroderma for several years who was not receiving immunosuppressive therapy. Her urinary protein turned positive with a progressive reduction in complement levels and positive anti-DNA antibodies. Kidney biopsy indicated mild mesangial proliferation with focal glomerular basement membrane (GBM) thickening and lucencies (Supplementary Figure S1, part 1). Immunofluorescent staining revealed mesangial Ig and complement deposition of a full house pattern with faint peripheral capillary IgG deposition (Supplementary Figure S1, parts 2 and 3).
      Citation: Kidney International 98, 6 (2020)
      PubDate: 2020-12
      DOI: 10.1016/j.kint.2020.04.035
      Issue No: Vol. 98, No. 6 (2020)
       
  • Tracheal necrotizing granulomatosis in antineutrophil cytoplasmic
           antibody–associated vasculitis
    • Authors: Pasquale Esposito; Stefano Tomaselli, Stefania Bianzina, Teresa Rampino
      First page: 1624
      Abstract: A 43-year-old woman presented at the emergency department with sore throat and fever for 2 weeks. On clinical examination, she only had diffuse decreased breath sounds. Laboratory evaluations revealed leucocytosis, anemia, and severe renal dysfunction (creatinine, 2408 μmol/l), requiring hemodialysis treatment.
      Citation: Kidney International 98, 6 (2020)
      PubDate: 2020-12
      DOI: 10.1016/j.kint.2020.04.012
      Issue No: Vol. 98, No. 6 (2020)
       
  • The Case Severe high-anion gap metabolic acidosis
    • Authors: Sara S. Jdiaa; Ali K. Abu-Alfa
      Pages: 1625 - 1626
      Abstract: An 80-year-old man was brought to the emergency department for decreased level of consciousness of 1-day duration. His past medical history was pertinent for hypertension, type 2 diabetes, chronic kidney disease stage 3a, and metastatic prostate cancer on palliative care. His medications included rosuvastatin, bisoprolol, prednisone, and daily acetaminophen for chronic pain. His past surgical history was relevant for transurethral resection of the prostate. On examination, the patient was hemodynamically stable but appeared weak and lethargic.
      Citation: Kidney International 98, 6 (2020)
      PubDate: 2020-12
      DOI: 10.1016/j.kint.2020.06.013
      Issue No: Vol. 98, No. 6 (2020)
       
  • The Case A 23-year-old male with hemoptysis
    • Authors: Georgina L. Irish; Philip Hesselman, Vadim K. Pedchenko, Philip A. Clayton, P. Toby Coates
      Pages: 1627 - 1628
      Abstract: A 23-year-old White Australian male presented with hemoptysis 9 days after kidney transplantation. This was his second kidney transplant for Alport syndrome, with genetic confirmation of COL4A5 gene mutation. His first transplant, from his father, lasted 2 years and then failed due to a vascular rejection in the setting of nonadherence. His second transplant was human leukocyte antigen–DR matched and from a deceased donor with donation after brain death. The patient received standard induction with tacrolimus, mycophenolate mofetil, prednisolone, and basiliximab.
      Citation: Kidney International 98, 6 (2020)
      PubDate: 2020-12
      DOI: 10.1016/j.kint.2020.07.050
      Issue No: Vol. 98, No. 6 (2020)
       
  • Translational Science Diet–Microbiota Interaction and Kidney Disease
           Progression
    • Authors: Ziad A. Massy; Tilman B. Drueke
      Abstract: Very high protein intake may lead to increased intraglomerular pressure, glomerular hyperfiltration, and chronic kidney disease (CKD). For this and other reasons dietary protein restriction has long been used with the aim of slowing the progression of CKD. In addition to the quantity of ingested protein, the quality of protein is also of importance for body growth, composition, and function. This also holds true for microbiota growth, composition, and function in the intestine. Generally speaking, nutrient intake is known to modify the relative abundance and the diversity of intestinal microbes, and dietary changes can induce alterations in gut microbial metabolite production.
      Citation: Kidney International (2020)
      PubDate: 2020-11-24
      DOI: 10.1016/j.kint.2020.11.006
       
  • Updating the International IgA Nephropathy Prediction Tool for use in
           children
    • Authors: Sean J. Barbour; Rosanna Coppo, Lee Er, Maria Luisa Russo, Zhi-Hong Liu, Jie Ding, Ritsuko Katafuchi, Norishige Yoshikawa, Hong Xu, Shoji Kagami, Yukio Yuzawa, Francesco Emma, Alexandra Cambier, Licia Peruzzi, Robert J. Wyatt, Daniel C. Cattran, International IgA Nephropathy Network
      Abstract: Although IgA nephropathy (IgAN) is a common cause of glomerulonephritis in children, the absence of a method to predict disease progression limits personalized risk-based treatment decisions. The adult International IgAN Prediction Tool comprises two validated Cox survival models that predict a 50% decline in estimated glomerular filtration rate (eGFR) or end stage kidney disease (ESKD) using clinical risk factors and Oxford MEST histology scores. Here, we updated the Prediction Tool for use in children using a multiethnic international cohort of 1,060 children with IgAN followed into adulthood.
      Citation: Kidney International (2020)
      PubDate: 2020-11-17
       
  • Atypical HUS relapse triggered by Covid-19.
    • Authors: Simon Ville; Sabine LE. Bot, Agnès Chapelet-Debout, Gilles Blancho, Véronique Fremeaux-Bachi, Clément Deltombe, Fadi Fakhouri
      Abstract: Microvascular injury, including thrombotic microangiopathy, has been widely reported as a hallmark pathological feature of organ injury in the setting of COVID-191. Accumulating data suggest that complement activation is implicated in the pathogenesis of COVID-19, including endothelial cell damage2–5. Some of these features are characteristic of atypical hemolytic uremic syndrome (aHUS), a prototypic disease of complement-mediated endothelial cell injury. We report the first case of aHUS relapse triggered by COVID-19.
      Citation: Kidney International (2020)
      PubDate: 2020-11-11
       
  • Results from the IRoc-GN international registry of patients with COVID-19
           and glomerular disease suggest close monitoring.
    • Authors: Meryl Waldman; Maria J. Soler, Clara García-Carro, Liz Lightstone, Tabitha Turner-Stokes, Megan Griffith, Joan Torras, Laura Martinez Valenzuela, Oriol Bestard, Colin Geddes, Oliver Flossmann, Kelly L. Budge, Chiara Cantarelli, Enrico Fiaccadori, Marco Delsante, Enrique Morales, Eduardo Gutierrez, Jose A. Niño-Cruz, Armando J. Martinez-Rueda, Giorgia Comai, Claudia Bini, Gaetano La Manna, Maria F. Slon, Joaquin Manrique, Irene Agraz, Ninet Sinaii, Paolo Cravedi
      Abstract: The effects of SARS-CoV-2 infection on individuals with immune-mediated glomerulonephritis, who are often undergoing immunosuppressive treatments, are unknown. Therefore, we created the International Registry of COVID infection in glomerulonephritis (IRoc-GN), and identified 40 patients with glomerulonephritis and COVID-19 followed in centers in North America and Europe. Detailed information on glomerulonephritis diagnosis, kidney parameters, and baseline immunosuppression prior to infection were recorded, as well as clinical presentation, laboratory values, treatment, complications, and outcomes of COVID-19.
      Citation: Kidney International (2020)
      PubDate: 2020-11-09
       
  • Characterization and implications of the initial estimated glomerular
           filtration rate ‘dip’ upon sodium-glucose co-transporter-2 inhibition
           with empagliflozin in the EMPA-REG OUTCOME trial.
    • Authors: Bettina J. Kraus; Matthew R. Weir, George L. Bakris, Michaela Mattheus, David Z.I. Cherney, Naveed Sattar, Hiddo J.L. Heerspink, Ivana Ritter, Maximilian von Eynatten, Bernard Zinman, Silvio E. Inzucchi, Christoph Wanner, Audrey Koitka-Weber
      Abstract: Treatment with sodium-glucose co-transporter-2 inhibitors induces an initial 3–5 ml/min/1.73 m2 decline in estimated glomerular filtration rate (eGFR). Although considered to be of hemodynamic origin and largely reversible, this ‘eGFR dip’ may cause concern in clinical practice, which highlights the need to better understand its incidence and clinical implications. In this post hoc analysis of the EMPA-REG OUTCOME trial, 6,668 participants randomized to empagliflozin 10 mg, 25 mg or placebo with eGFR available at baseline and week four were categorized by initial eGFR change into three groups; over 10% decline (‘eGFR dipper’), over 0 and up to 10% decline (‘eGFR intermediate’), no eGFR decline (‘eGFR non-dipper’).
      Citation: Kidney International (2020)
      PubDate: 2020-11-09
       
  • Reduced Lon protease 1 expression in podocytes contributes to the
           pathogenesis of podocytopathy
    • Authors: Wei Gong; Jiayu Song, Jing Liang, Haoyang Ma, Wenxiao Wu, Yue Zhang, Li Yang, Songming Huang, Zhanjun Jia, Aihua Zhang
      Abstract: Emerging evidence has shown that mitochondrial dysfunction is closely related to the pathogenesis of podocytopathy, but the molecular mechanisms mediating mitochondrial dysfunction in podocytes remain unclear. Lon protease 1 is an important soluble protease localized in the mitochondrial matrix, although its exact role in podocyte injury has yet to be determined. Here we investigated the specific role of this protease in podocyte in glomerular injury and the progression of podocytopathy using podocyte-specific Lon protease 1 knockout mice, murine podocytes in culture and kidney biopsy samples from patients with focal segmental glomerular sclerosis and minimal change disease.
      Citation: Kidney International (2020)
      PubDate: 2020-11-09
       
  • A propensity score matched analysis indicates screening for asymptomatic
           coronary artery disease does not predict cardiac events in kidney
           transplant recipients.
    • Authors: Ailish Nimmo; John Forsyth, Gabriel Oniscu, Matthew Robb, Chris Watson, James Fotheringham, Paul J. Roderick, Rommel Ravanan, Dominic M. Taylor
      Abstract: Screening for asymptomatic coronary artery disease prior to kidney transplantation aims to reduce peri- and post-operative cardiac events. It is uncertain if this is achieved. Here, we investigated whether pre-transplant screening with a stress test or coronary angiogram associated with any difference in major adverse cardiac events (MACE) up to five years post-transplantation. We examined a national prospective cohort recruited to the Access to Transplant and Transplant Outcome Measures study who received a kidney transplant between 2011-2017, and linked patient demographics and details of cardiac screening investigations to outcome data extracted from the Hospital Episode Statistics dataset and United Kingdom Renal Registry.
      Citation: Kidney International (2020)
      PubDate: 2020-11-07
       
  • The STARMEN trial indicates that alternating treatment with
           corticosteroids and cyclophosphamide is superior to sequential treatment
           with tacrolimus and rituximab in primary membranous nephropathy.
    • Authors: Gema Fernández-Juárez; Jorge Rojas-Rivera, Anne-Els van de Logt, Joana Justino, Angel Sevillano, Fernando Caravaca-Fontán, Ana Ávila, Cristina Rabasco, Virginia Cabello, Alfonso Varela, Montserrat Díez, Guillermo Martín-Reyes, Marian Goicoechea Diezhandino, Luis F. Quintana, Irene Agraz, Juan Ramón Gómez-Martino, Mercedes Cao, Antolina Rodríguez-Moreno, Begoña Rivas, Cristina Galeano, Jose Bonet, Ana Romera, Amir Shabaka, Emmanuelle Plaisier, Mario Espinosa, Jesus Egido, Alfonso Segarra, Gérard Lambeau, Pierre Ronco, Jack Wetzels, Manuel Praga, STARMEN investigators
      Abstract: A cyclical corticosteroid-cyclophosphamide regimen is recommended for patients with primary membranous nephropathy at high risk of progression. We hypothesized that sequential therapy with tacrolimus and rituximab is superior to cyclical alternating treatment with corticosteroids and cyclophosphamide in inducing persistent remission in these patients. This was tested in a randomized, open-label controlled trial of 86 patients with primary membranous nephropathy and persistent nephrotic syndrome after six-months observation and assigned 43 each to receive six-month cyclical treatment with corticosteroid and cyclophosphamide or sequential treatment with tacrolimus (full-dose for six months and tapering for another three months) and rituximab (one gram at month six).
      Citation: Kidney International (2020)
      PubDate: 2020-11-06
       
  • Targeting fibroblast growth factor 23-responsive pathways uncovers
           controlling genes in kidney mineral metabolism.
    • Authors: Pu Ni; Erica L. Clinkenbeard, Megan L. Noonan, Joseph M. Richardville, Jeanette McClintick, Takashi Hato, Danielle Janosevic, Ying-Hua Cheng, Tarek M. El-Achkar, Michael T. Eadon, Pierre C. Dagher, Kenneth E. White
      Abstract: Fibroblast Growth Factor 23 (FGF23) is a bone-derived hormone that reduces kidney phosphate reabsorption and 1,25(OH)2 vitamin D synthesis via its required co-receptor alpha-Klotho. To identify novel genes that could serve as targets to control FGF23-mediated mineral metabolism, gene array and single-cell RNA sequencing were performed in wild type mouse kidneys. Gene array demonstrated that heparin-binding EGF-like growth factor (HBEGF) was significantly up-regulated following one-hour FGF23 treatment of wild type mice.
      Citation: Kidney International (2020)
      PubDate: 2020-11-04
       
  • Deletion of the proton receptor OGR1 in mouse osteoclasts impairs
           metabolic acidosis-induced bone resorption.
    • Authors: Nancy S. Krieger; Luojing Chen, Jennifer Becker, Michaela Chan, David A. Bushinsky
      Abstract: Metabolic acidosis induces osteoclastic bone resorption and inhibits osteoblastic bone formation. Previously we found that mice with a global deletion of the proton receptor OGR1 had increased bone density although both osteoblast and osteoclast activity were increased. To test whether direct effects on osteoclast OGR1 are critical for metabolic acidosis stimulated bone resorption, we generated knockout mice with an osteoclast-specific deletion of OGR1 (knockout mice). We studied bones from three-month old female mice and the differentiated osteoclasts derived from bone marrow of femurs from these knockout and wild type mice.
      Citation: Kidney International (2020)
      PubDate: 2020-11-04
       
  • Changes in cancer incidence and outcomes among kidney transplant
           recipients in the United States over a thirty-year period.
    • Authors: Christopher D. Blosser; Gregory Haber, Eric A. Engels
      Abstract: Recipients of kidney transplants have elevated cancer risk compared with the general population. Improvements over time in transplant care and cancer treatment may have affected incidence and outcomes of cancer among recipients of kidney transplant. To evaluate this, we used linked United States transplant and cancer registry data to study 101,014 adult recipients of kidney transplants over three decades (1987-1996, 1997-2006, 2007-2016). Poisson regression was used to assess trends in incidence for cancer overall and seven common cancers.
      Citation: Kidney International (2020)
      PubDate: 2020-11-04
       
  • Estimation of the glomerular filtration rate in children and young adults
           using the CKD-EPI equation with age-adjusted creatinine values.
    • Authors: Jonas Björk; Ulf Nyman, Anders Larsson, Pierre Delanaye, Hans Pottel
      Abstract: The CKD-EPI creatinine-based estimation equation for glomerular filtration rate (GFR) cannot be used in children, overestimates GFR in young adults, and its combination with the KDIGO recommended pediatric CKiD (Schwartz bedside) equation causes implausible increases in estimated GFR when switching from pediatric to adult care. By establishing sex-specific creatinine growth curves for children and young adults, creatinine levels of children and young adults below age 40 years were adjusted with 40 as assigned age and applied in the CKD-EPI equation.
      Citation: Kidney International (2020)
      PubDate: 2020-11-03
       
  • Kidney epithelial targeted mitochondrial transcription factor A deficiency
           results in progressive mitochondrial depletion associated with severe
           cystic disease.
    • Authors: Ken Ishii; Hanako Kobayashi, Kensei Taguchi, Nan Guan, Andraia Li, Carmen Tong, Olena Davidoff, Pamela V. Tran, Madhulika Sharma, Navdeep S. Chandel, Meghan E. Kapp, Agnes B. Fogo, Craig R. Brooks, Volker H. Haase
      Abstract: Abnormal mitochondrial function is a well-recognized feature of acute and chronic kidney diseases. To gain insight into the role of mitochondria in kidney homeostasis and pathogenesis, we targeted mitochondrial transcription factor A (TFAM), a protein required for mitochondrial DNA replication and transcription that plays a critical part in the maintenance of mitochondrial mass and function. To examine the consequences of disrupted mitochondrial function in kidney epithelial cells, we inactivated TFAM in sine oculis-related homeobox 2-expressing kidney progenitor cells.
      Citation: Kidney International (2020)
      PubDate: 2020-11-03
       
  • Cannabinoid receptor type 2 promotes kidney fibrosis through orchestrating
           β-catenin signaling
    • Authors: Shan Zhou; Qinyu Wu, Xu Lin, Xian Ling, Jinhua Miao, Xi Liu, Chengxiao Hu, Yunfang Zhang, Nan Jia, Fan Fan Hou, Youhua Liu, Lili Zhou
      Abstract: The endocannabinoid system has multiple effects. Through interacting with cannabinoid receptor type 1 and type 2, this system can greatly affect disease progression. Previously, we showed that activated cannabinoid receptor type 2 (CB2) mediated kidney fibrosis. However, the underlying mechanisms remain underdetermined. Here, we report that CB2 was upregulated predominantly in kidney tubular epithelial cells in unilateral urinary obstruction and ischemia-reperfusion injury models in mice, and in patients with a variety of kidney diseases.
      Citation: Kidney International (2020)
      PubDate: 2020-11-02
      DOI: 10.1016/j.kint.2020.09.025
       
  • Results of the PROPINE randomized controlled study suggest tapering of
           prednisone treatment for relapses of steroid sensitive nephrotic syndrome
           is not necessary in children.
    • Authors: Antonio Gargiulo; Laura Massella, Barbara Ruggiero, Lucilla Ravà, Marta Ciofi degli Atti, Marco Materassi, Francesca Lugani, Elisa Benetti, William Morello, Daniela Molino, Francesca Mattozzi, Marco Pennesi, Silvio Maringhini, Andrea Pasini, Bruno Gianoglio, Carmine Pecoraro, Giovanni Montini, Luisa Murer, Gian Marco Ghiggeri, Paola Romagnani, Marina Vivarelli, Francesco Emma
      Abstract: Corticosteroid-related toxicity in children with steroid-sensitive nephrotic syndrome is primarily related to the cumulative dose of prednisone. To optimize treatment of relapses, we conducted the PROPINE study, a multicentric, open-label, randomized, superiority trial. Seventy-eight relapsing children aged 3-17 years who had not received steroid-sparing medications during the previous 12 months were randomized to receive, from day five after remission, either 18 doses of 40 mg/m2 of prednisone on alternate days (short arm), or the same cumulative dose tapered over double the time (long arm).
      Citation: Kidney International (2020)
      PubDate: 2020-11-02
      DOI: 10.1016/j.kint.2020.09.024
       
  • Mechanisms of vascular dysfunction in the interleukin-10-deficient murine
           model of preeclampsia indicate nitric oxide dysregulation.
    • Authors: H. Cubro; K.A. Nath, S. Suvakov, O. Garcia-Valencia, S. Parashuram, W.M. White, T.L. Weissgerber, M.C. Nath, N.M. Milic, F. Sontag, L.V. d’Uscio, Y. Zhu, J.L. Kirkland, T. Tchkonia, M.P. Alexander, R.A. Quinton, Z.S. Katusic, J.P. Grande, V.D. Garovic
      Abstract: Preeclampsia is a pregnancy-specific hypertensive disorder characterized by proteinuria, and vascular injury in the second half of pregnancy. We hypothesized that endothelium-dependent vascular dysfunction is present in a murine model of preeclampsia based on administration of human preeclamptic sera to interleukin -10-/- mice and studied mechanisms that underlie vascular injury. Pregnant wild type and IL-10-/- mice were injected with either normotensive or severe preeclamptic patient sera (sPE) during gestation.
      Citation: Kidney International (2020)
      PubDate: 2020-10-31
      DOI: 10.1016/j.kint.2020.09.034
       
  • MAGI-2 orchestrates the localization of backbone proteins in the slit
           diaphragm of podocytes.
    • Authors: Hiroyuki Yamada; Naritoshi Shirata, Shinichi Makino, Takafumi Miyake, Juan Alejandro Oliva Trejo, Kanae Yamamoto-Nonaka, Mitsuhiro Kikyo, Maulana A. Empitu, Ika N. Kadariswantiningsih, Maiko Kimura, Koichiro Ichimura, Hideki Yokoi, Masashi Mukoyama, Akitsu Hotta, Katsuhiko Nishimori, Motoko Yanagita, Katsuhiko Asanuma
      Abstract: Podocytes are highly specialized cells within the glomerulus that are essential for ultrafiltration. The slit-diaphragm between the foot processes of podocytes functions as a final filtration barrier to prevent serum protein leakage into urine. The slit-diaphragm consists mainly of Nephrin and Neph1, and localization of these backbone proteins is essential to maintaining the integrity of the glomerular filtration barrier. However, the mechanisms that regulate the localization of these backbone proteins have remained elusive.
      Citation: Kidney International (2020)
      PubDate: 2020-10-31
      DOI: 10.1016/j.kint.2020.09.027
       
  • New insights from SONAR indicate adding sodium glucose co-transporter 2
           inhibitors to an endothelin receptor antagonist mitigates fluid retention
           and enhances albuminuria reduction.
    • Authors: Hiddo J.L. Heerspink; Donald E. Kohan, Dick de Zeeuw
      Abstract: The diuretic effects achieved with sodium glucose co-transporter 2 inhibitors (SGLT2i) may offset fluid retaining effects of the endothelin receptor antagonist (ERA) atrasentan while effects on albuminuria and kidney protection of both drug classes may be complimentary due to distinct mechanisms of action. Here, post-hoc analysis of the SONAR trial, in patients with type 2 diabetes and chronic kidney disease, show that six-weeks treatment with combined SGLT2i/atrasentan versus atrasentan alone decreased body weight, a surrogate for fluid retention, and further decreased albuminuria.
      Citation: Kidney International (2020)
      PubDate: 2020-10-31
      DOI: 10.1016/j.kint.2020.09.026
       
  • Clinical and immunological follow-up of very long-term kidney transplant
           
    • Authors: Amaury Dujardin; Mélanie Chesneau, Florian Dubois, Richard Danger, Linh Bui, Clarisse Kerleau, Pierrick Guérif, Sophie Brouard, Jacques Dantal
      Abstract: Operationally tolerant kidney transplant recipients harbor an immunological signature, associated with low rejection risk, and focused on B lymphocytes. Here, we investigated whether patients with long-term transplantation and still on immunosuppressive therapy would present such a signature of low immunological rejection risk, compared to more recently transplanted patients. Of 114 kidney transplant recipients enrolled, 38 with more than 25 years of graft survival and stable graft function under calcineurin inhibitors, were matched with two different groups of transplanted patients (10-15 and 5-7 years after transplantation).
      Citation: Kidney International (2020)
      PubDate: 2020-10-30
      DOI: 10.1016/j.kint.2020.09.036
       
  • EOS789, a broad-spectrum inhibitor of phosphate transport, is safe with an
           indication of efficacy in a Phase 1b randomized cross-over trial in
           hemodialysis patients.
    • Authors: Kathleen M. Hill Gallant; Elizabeth R. Stremke, Laurie Trevino, Ranjani N. Moorthi, Simit Doshi, Meryl E. Wastney, Nozomi Hisada, Jotaro Sato, Yoshitaka Ogita, Naohisa Fujii, Yuya Matsuda, Takei Kake, Sharon M. Moe
      Abstract: The treatment of hyperphosphatemia remains challenging in patients receiving hemodialysis. This Phase 1b study assessed safety and efficacy of EOS789, a novel pan-inhibitor of phosphate transport (NaPi-2b, PiT-1, PiT-2) on intestinal phosphate absorption in patients receiving intermittent hemodialysis therapy. Two cross-over, randomized order studies of identical design (ten patients each) compared daily EOS789 50 mg to placebo with meals and daily EOS789 100 mg vs EOS789 100 mg plus 1600 mg sevelamer with meals.
      Citation: Kidney International (2020)
      PubDate: 2020-10-30
      DOI: 10.1016/j.kint.2020.09.035
       
  • Complement activation is a crucial driver of acute kidney injury in
           rhabdomyolysis
    • Authors: Idris Boudhabhay; Victoria Poillerat, Anne Grunenwald, Carine Torset, Juliette Leon, Marie V. Daugan, Francesca Lucibello, Khalil El Karoui, Amandine Ydee, Sophie Chauvet, Patrick Girardie, Steven Sacks, Conrad A. Farrar, Peter Garred, Romain Berthaud, Moglie Le Quintrec, Marion Rabant, Pascale de Lonlay, Caroline Rambaud, Viviane Gnemmi, Veronique Fremeaux-Bacchi, Marie Frimat, Lubka T. Roumenina
      Abstract: Rhabdomyolysis is a life-threatening condition caused by skeletal muscle damage with acute kidney injury being the main complication dramatically worsening the prognosis. Specific treatment for rhabdomyolysis-induced acute kidney injury is lacking and the mechanisms of the injury are unclear. To clarify this, we studied intra-kidney complement activation (C3d and C5b-9 deposits) in tubules and vessels of patients and mice with rhabdomyolysis-induced acute kidney injury. The lectin complement pathway was found to be activated in the kidney; likely via an abnormal pattern of Fut2-dependent cell fucosylation, recognized by the pattern recognition molecule collectin-11 and this proceeded in a C4-independent, bypass manner.
      Citation: Kidney International (2020)
      PubDate: 2020-10-30
      DOI: 10.1016/j.kint.2020.09.033
       
  • THREE-DIMENSIONAL ARCHITECTURE OF NEPHRONS IN THE NORMAL AND CYSTIC KIDNEY
    • Authors: Thomas Blanc; Nicolas Goudin, Mohamad Zaidan, Meriem Garfa Traore, Frank Bienaime, Lisa Turinsky, Serge Garbay, Clément Nguyen, Martine Burtin, Gérard Friedlander, Fabiola Terzi, Marco Pontoglio
      Abstract: Kidney function is crucially dependent on the complex three-dimensional structure of nephrons. Any distortion of their shape may lead to kidney dysfunction. Traditional histological methods present major limitations for three-dimensional tissue reconstruction. Here, we combined tissue clearing, multi-photon microscopy and digital tracing for the reconstruction of single nephrons under physiological and pathological conditions. Sets of nephrons differing in location, shape and size according to their function were identified.
      Citation: Kidney International (2020)
      PubDate: 2020-10-30
      DOI: 10.1016/j.kint.2020.09.032
       
  • Stabilization of Hypoxia-Inducible Factor Ameliorates Glomerular Injury
           Sensitization after Tubulointerstitial Injury
    • Authors: Jun Zou; Jaewon Yang, Xiaoye Zhu, Jianyong Zhong, Ahmed Elshaer, Taiji Matsusaka, Ira Pastan, Volker H. Haase, Hai-Chun Yang, Agnes B. Fogo
      Abstract: Previously, we found that mild tubulointerstitial injury sensitizes glomeruli to subsequent injury. Here, we evaluated whether stabilization of hypoxia-inducible factor-α (HIF-α), a key regulator of tissue response to hypoxia, ameliorates tubulointerstitial injury and impact on subsequent glomerular injury. Nep25 mice, which express the human CD25 receptor on podocytes under control of the nephrin promotor and develop glomerulosclerosis when a specific toxin is administered were used. Tubulointerstitial injury, evident by week two, was induced by folic acid, and mice were treated with an HIF stabilizer, dimethyloxalylglycine or vehicle from week three to six.
      Citation: Kidney International (2020)
      PubDate: 2020-10-30
      DOI: 10.1016/j.kint.2020.09.031
       
  • Meta-analysis uncovers genome-wide significant variants for rapid kidney
           function decline.
    • Authors: Mathias Gorski; Bettina Jung, Yong Li, Pamela R. Matias-Garcia, Matthias Wuttke, Stefan Coassin, Chris H.L. Thio, Marcus E. Kleber, Thomas W. Winkler, Veronika Wanner, Jin-Fang Chai, Audrey Y. Chu, Massimiliano Cocca, Mary F. Feitosa, Sahar Ghasemi, Anselm Hoppmann, Katrin Horn, Man Li, Teresa Nutile, Markus Scholz, Karsten B. Sieber, Alexander Teumer, Adrienne Tin, Judy Wang, Bamidele O. Tayo, Tarunveer S. Ahluwalia, Peter Almgren, Stephan J.L. Bakker, Bernhard Banas, Nisha Bansal, Mary L. Biggs, Eric Boerwinkle, Erwin P. Bottinger, Hermann Brenner, Robert J. Carroll, John Chalmers, Miao-Li Chee, Miao-Ling Chee, Ching-Yu Cheng, Josef Coresh, Martin H. de Borst, Frauke Degenhardt, Kai-Uwe Eckardt, Karlhans Endlich, Andre Franke, Sandra Freitag-Wolf, Piyush Gampawar, Ron T. Gansevoort, Mohsen Ghanbari, Christian Gieger, Pavel Hamet, Kevin Ho, Edith Hofer, Bernd Holleczek, Valencia Hui Xian Foo, Nina Hutri-Kähönen, Shih-Jen Hwang, M. Arfan Ikram, Navya Shilpa Josyula, Mika Kähönen, Chiea-Chuen Khor, Wolfgang Koenig, Holly Kramer, Bernhard K. Krämer, Brigitte Kühnel, Leslie A. Lange, Terho Lehtimäki, Wolfgang Lieb, Lifelines cohort study, Regeneron Genetics Center, Ruth J.F. Loos, Mary Ann Lukas, Leo-Pekka Lyytikäinen, Christa Meisinger, Thomas Meitinger, Olle Melander, Yuri Milaneschi, Pashupati P. Mishra, Nina Mononen, Josyf C. Mychaleckyj, Girish N. Nadkarni, Matthias Nauck, Kjell Nikus, Boting Ning, Ilja M. Nolte, Michelle L. O’Donoghue, Marju Orho-Melander, Sarah A. Pendergrass, Brenda W.J. H. Penninx, Michael H. Preuss, Bruce M. Psaty, Laura M. Raffield, Olli T. Raitakari, Rainer Rettig, Myriam Rheinberger, Kenneth M. Rice, Alexander R. Rosenkranz, Peter Rossing, Jerome I. Rotter, Charumathi Sabanayagam, Helena Schmidt, Reinhold Schmidt, Ben Schöttker, Christina-Alexandra Schulz, Sanaz Sedaghat, Christian M. Shaffer, Konstantin Strauch, Silke Szymczak, Kent D. Taylor, Johanne Tremblay, Layal Chaker, Pim van der Harst, Peter J. van der Most, Niek Verweij, Uwe Völker, Melanie Waldenberger, Lars Wallentin, Dawn M. Waterworth, Harvey D. White, James G. Wilson, Tien-Yin Wong, Mark Woodward, Qiong Yang, Masayuki Yasuda, Laura M. Yerges-Armstrong, Yan Zhang, Harold Snieder, Christoph Wanner, Carsten A. Böger, Anna Köttgen, Florian Kronenberg, Cristian Pattaro, Iris M. Heid
      Abstract: Rapid decline of glomerular filtration rate estimated from creatinine (eGFRcrea) is associated with severe clinical endpoints. In contrast to cross-sectionally assessed eGFRcrea, the genetic basis for rapid eGFRcrea decline is largely unknown. To help define this, we meta-analyzed 42 genome-wide association studies from the Chronic Kidney Diseases Genetics Consortium and United Kingdom Biobank to identify genetic loci for rapid eGFRcrea decline. Two definitions of eGFRcrea decline were used: 3 mL/min/1.73m2/year or more (“Rapid3”; encompassing 34,874 cases, 107,090 controls) and eGFRcrea decline 25% or more and eGFRcrea under 60 mL/min/1.73m2 at follow-up among those with eGFRcrea 60 mL/min/1.73m2 or more at baseline (“CKDi25”; encompassing 19,901 cases, 175,244 controls).
      Citation: Kidney International (2020)
      PubDate: 2020-10-30
      DOI: 10.1016/j.kint.2020.09.030
       
  • Ivemark II syndrome, a renal-hepatic-pancreatic dysplasia.
    • Authors: Penelope Jordan; Christelle Arrondel, Bettina Bessières, Aude Tessier, Tania Attié-Bitach, Sarah Guterman, Vincent Morinière, Corinne Antignac, Sophie Saunier, Marie-Claire Gubler, Laurence Heidet
      Abstract: DNAJB11 (DnaJ Heat Shock Protein Family (Hsp40) Member B11) heterozygous loss of; function variations have been reported in autosomal dominant cystic kidney disease with extensive fibrosis, associated with maturation and trafficking defect involving both the autosomal dominant polycystic kidney disease protein polycystin-1 and the autosomal dominant tubulointerstitial kidney disease protein uromodulin. Here we show that biallelic pathogenic variations in DNAJB11 lead to a severe fetal disease including enlarged cystic kidneys, dilation and proliferation of pancreatic duct cells, and liver ductal plate malformation, an association known as Ivemark II syndrome.
      Citation: Kidney International (2020)
      PubDate: 2020-10-28
      DOI: 10.1016/j.kint.2020.09.029
       
  • Complement activity is regulated in C3 glomerulopathy by IgG-factor H
           fusion proteins with and without properdin targeting domains.
    • Authors: Alyssa C. Gilmore; Yuchun Zhang, H Terence Cook, Deborah P. Lavin, Suresh Katti, Yi Wang, Krista Johnson, SungKwon Kim, Matthew C. Pickering
      Abstract: C3 glomerulopathy is characterized by accumulation of complement C3 within glomeruli. Causes include, but are not limited to, abnormalities in factor H, the major negative regulator of the complement alternative pathway. Factor H-deficient (Cfh-/-) mice develop C3 glomerulopathy together with a reduction in plasma C3 levels. Using this model, we assessed the efficacy of two fusion proteins containing the factor H alternative pathway regulatory domains (FH1-5) linked to either a non-targeting mouse immunoglobulin (IgG-FH1-5) or to an anti-mouse properdin antibody (Anti-P-FH1-5).
      Citation: Kidney International (2020)
      PubDate: 2020-10-28
      DOI: 10.1016/j.kint.2020.09.028
       
  • Patient-reported outcomes and experiences in the transition of
           undocumented patients from emergency to scheduled hemodialysis
    • Authors: Lilia Cervantes; Allison Tong, Claudia Camacho, Adriana Collings, Neil R. Powe
      Abstract: Undocumented immigrants with kidney failure can only access dialysis after presenting critically ill to an emergency department in most states within the United States. How access to scheduled dialysis might improve or harm patient experience is currently unknown. To clarify this, we assessed patient reported outcomes and experiences of undocumented patients who transitioned from emergency to scheduled dialysis. Pre-post intervention interviews were conducted using a mixed-methods study (questionnaires and interviews) in a Colorado hospital.
      Citation: Kidney International (2020)
      PubDate: 2020-10-28
      DOI: 10.1016/j.kint.2020.07.024
       
  • The Case for Early Identification and Intervention of Chronic Kidney
           Disease: Conclusions from a Kidney Disease: Improving Global Outcomes
           (KDIGO) Controversies Conference
    • Authors: Michael G. Shlipak; Sri Lekha Tummalapalli, L. Ebony Boulware, Morgan E. Grams, Joachim H. Ix, Vivekanand Jha, Andre P. Kengne, Magdalena Madero, Borislava Mihaylova, Navdeep Tangri, Michael Cheung, Michel Jadoul, Wolfgang C. Winkelmayer, Sophia Zoungas, for Conference Participants
      Abstract: Chronic kidney disease causes substantial global morbidity and increases cardiovascular and all-cause mortality. Unlike other chronic diseases with established strategies for screening, there has been no consensus on whether health systems and governments should prioritize early identification and intervention for CKD. Guidelines on evaluating and managing early CKD are available but have not been universally adopted in the absence of incentives or quality measures for prioritizing CKD care. The burden of CKD falls disproportionately upon persons with lower socioeconomic status, who have a higher prevalence of CKD, limited access to treatment, and poorer outcomes.
      Citation: Kidney International (2020)
      PubDate: 2020-10-27
       
  • Rho GTPase regulatory proteins in podocytes
    • Authors: Jun Matsuda; Kana Asano-Matsuda, Thomas Kitzler, Tomoko Takano
      Abstract: Rho-family of small GTPases (Rho GTPases) are the master regulators of the actin cytoskeleton and consist of 22 members. Previous studies implicated dysregulation of Rho GTPases in podocytes in the pathogenesis of proteinuric glomerular diseases. Rho GTPases are primarily regulated by the three families of proteins; guanine nucleotide exchange factors (GEFs, 82 members), GTPase activating proteins (GAPs, 69 members), and GDP dissociation inhibitors (GDIs, 3 members). Since the regulatory proteins far outnumber their substrate Rho GTPases, and act in concert in a cell-/context-dependent manner, upstream regulatory mechanism directing Rho GTPases in podocytes is largely unknown.
      Citation: Kidney International (2020)
      PubDate: 2020-10-26
      DOI: 10.1016/j.kint.2020.08.035
       
  • Increase in phosphaturia by inhibition of renal sodium-dependent phosphate
           co-transporter NPT2a
    • Authors: Tilman B. Drueke
      Abstract: Numerous mechanisms are involved in maintaining serum phosphate concentration in the normal range, mainly by regulating phosphate absorption in the gut and tubular phosphate reabsorption in the kidney. In the gut, phosphate is absorbed by passive paracellular diffusion and active transcellular transport, mainly via NPT2b, the major sodium phosphate co-transporter in the small intestine (1). Active phosphate absorption is enhanced by 1,25(OH)2 vitamin D. Intestinal phosphate absorption can be reduced by several approaches (1), including reduction of dietary phosphate intake, chelation of phosphate in the gut lumen (2), specific inhibition of NPT2b activity by small-molecule inhibitors (3), non-specific inhibition of NPT2b by niacin or its derivative nicotinamide (2), and reduction of passive paracellular phosphate flux via inhibition of the sodium/hydrogen exchanger 3 (4).
      Citation: Kidney International (2020)
      PubDate: 2020-10-14
      DOI: 10.1016/j.kint.2020.09.022
       
  • Neural cell adhesion molecule 1 is a novel autoantigen in membranous lupus
           nephritis.
    • Authors: Tiffany Caza; Samar Hassen, Michael Kuperman, Shree Sharma, Zeljko Dvanajscak, John Arthur, Rick Edmondson, Aaron Storey, Christian Herzog, Daniel Kenan, Christopher Larsen
      Abstract: Membranous lupus nephritis is a frequent cause of nephrotic syndrome in patients with systemic lupus erythematosus. It has been shown in phospholipase A2 receptor positive membranous; nephropathy that known antibodies can be detected within sera, determination of the target; autoantigen can have diagnostic significance, inform prognosis, and enable non-invasive; monitoring of disease activity. Here we utilized mass spectrometry for antigen discovery in laser; captured microdissected glomeruli from formalin-fixed paraffin embedded tissue and tissue; protein G immunoprecipitation studies to interrogate immune complexes from frozen kidney; biopsy tissue.
      Citation: Kidney International (2020)
      PubDate: 2020-10-09
      DOI: 10.1016/j.kint.2020.09.016
       
  • How mTORC1 makes sense of nutrients
    • Authors: Alessandro Luciani; Massimiliano Stagi
      Abstract: Mammalian cells must sense and respond to fluctuations in environmental nutrient concentrations to preserve homeostasis.1 A key step in this process is the recruitment of an ancient protein kinase called the mammalian Target of Rapamycin (mTOR) and its associated regulatory complex 1 (mTORC1) to the surface of the endolysosome — an organelle that functions in the degradation and recycling of cellular macromolecules.1 There, the kinase activity of mTORC1 is initiated by its activator, the small GTPase Rheb, which conveys the second set of different stimuli2 (e.g., cellular energy status, oxygen levels and growth factors; Figure 1a).
      Citation: Kidney International (2020)
      PubDate: 2020-09-30
      DOI: 10.1016/j.kint.2020.07.052
       
  • The sodium/proton exchanger NHA2 regulates blood pressure through a
           WNK4-NCC dependent pathway in the kidney.
    • Authors: Manuel A. Anderegg; Giuseppe Albano, Daniela Hanke, Christine Deisl, Dominik E. Uehlinger, Simone Brandt, Rajesh Bhardwaj, Matthias A. Hediger, Daniel G. Fuster
      Abstract: NHA2 is a sodium/proton exchanger associated with arterial hypertension in humans, but the role of NHA2 in kidney function and blood pressure homeostasis is currently unknown. Here we show that NHA2 localizes almost exclusively to distal convoluted tubules in the kidney. NHA2 knock-out mice displayed reduced blood pressure, normocalcemic hypocalciuria and an attenuated response to the thiazide diuretic hydrochlorothiazide. Phosphorylation of the thiazide-sensitive sodium/chloride cotransporter NCC and its upstream activating kinase Ste20/SPS1-related proline/alanine rich kinase (SPAK), as well as the abundance of with no lysine kinase 4 (WNK4), were significantly reduced in the kidneys of NHA2 knock-out mice.
      Citation: Kidney International (2020)
      PubDate: 2020-09-18
      DOI: 10.1016/j.kint.2020.08.023
       
  • Immune evasion in renal cell carcinoma: biology, clinical translation,
           future directions
    • Authors: Xiaoyang Wang; Robert Lopez, Rebecca A. Luchtel, Sassan Hafizi, Benjamin Gartrell, Niraj Shenoy
      Abstract: Targeted therapies and immune checkpoint inhibitors have advanced the treatment landscape of Renal Cell Carcinoma (RCC) over the last decade. While checkpoint inhibitors have demonstrated survival benefit and are currently approved in the front-line and second-line settings, primary and secondary resistance is common. A comprehensive understanding of the mechanisms of immune evasion in RCC is therefore critical to the development of effective combination treatment strategies. This article reviews the current understanding of the different, yet coordinated, mechanisms adopted by RCC cells to evade immune killing; summarizes various aspects of clinical translation thus far, including the currently registered RCC clinical trials exploring agents in combination with checkpoint inhibitors; and provides perspectives on the current landscape and future directions for the field.
      Citation: Kidney International (2020)
      PubDate: 2020-09-16
      DOI: 10.1016/j.kint.2020.08.028
       
  • Plasma cadmium is associated with increased risk of long-term kidney graft
           failure.
    • Authors: Camilo G. Sotomayor; Dion Groothof, Joppe J. Vodegel, Michele F. Eisenga, Tim J. Knobbe, Jan IJmker, Rosa G.M. Lammerts, Martin H. de Borst, Stefan P. Berger, Ilja M. Nolte, Ramón Rodrigo, Riemer H.J.A. Slart, Gerjan J. Navis, Daan J. Touw, Stephan J.L. Bakker
      Abstract: The kidney is one of the most sensitive organs to cadmium-induced toxicity, particularly in conditions of long-term oxidative stress. We hypothesized that, in kidney transplant recipients, nephrotoxic exposure to cadmium represents an overlooked hazard for optimal graft function. To test this, we performed a prospective cohort study and included 672 outpatient kidney transplant recipients with a functioning graft of beyond one year. The median plasma cadmium was 58 ng/L. During a median 4.9 years of follow-up, 78 kidney transplant recipients developed graft failure with a significantly different distribution across tertiles of plasma cadmium (13, 26, and 39 events, respectively).
      Citation: Kidney International (2020)
      PubDate: 2020-09-13
      DOI: 10.1016/j.kint.2020.08.027
       
  • Subgroup analysis of the ASPirin in Reducing Events in the Elderly
           randomized clinical trial suggest aspirin did not improve outcomes in
           older adults with chronic kidney disease.
    • Authors: Rory Wolfe; James B. Wetmore, Robyn L. Woods, John J. McNeil, Hugh Gallagher, Paul Roderick, Rowan Walker, Mark R. Nelson, Christopher M. Reid, Raj C. Shah, Michael E. Ernst, Jessica E. Lockery, Andrew M. Tonkin, Walter P. Abhayaratna, Peter Gibbs, Erica M. Wood, Suzanne E. Mahady, Jeff D. Williamson, Geoffrey A. Donnan, Geoffrey C. Cloud, Anne M. Murray, Kevan R. Polkinghorne, ASPREE Investigator Group
      Abstract: The role of aspirin for primary prevention in older adults with chronic kidney disease (CKD) is unclear. Therefore, post hoc analysis of the randomized controlled trial ASPirin in Reducing Events in the Elderly (ASPREE) was undertaken comparing 100 mg of enteric-coated aspirin daily against matching placebo. Participants were community dwelling adults aged 70 years and older in Australia, 65 years and older in the United States, all free of a history of dementia or cardiovascular disease and of any disease expected to lead to death within five years.
      Citation: Kidney International (2020)
      PubDate: 2020-09-10
      DOI: 10.1016/j.kint.2020.08.011
       
  • Mineral bone disease in autosomal dominant polycystic kidney disease.
    • Authors: Berenice Gitomer; Renata Pereira, Isidro B. Salusky, Jason W. Stoneback, Tamara Isakova, Xuan Cai, Lorien S. Dalrymple, Norma Ofsthun, Zhiying You, Harmut H. Malluche, Franklin Maddux, Diana George, Vicente Torres, Arlene Chapman, Theodore I. Steinman, Myles Wolf, Michel Chonchol
      Abstract: Mice with disruption of Pkd1 in osteoblasts demonstrate reduced bone mineral density, trabecular bone volume and cortical thickness. To date, the bone phenotype in adult patients with autosomal dominant polycystic kidney disease (ADPKD) with stage I and II chronic kidney disease has not been investigated. To examine this, we characterized biochemical markers of mineral metabolism, examined bone turnover and biology, and estimated risk of fracture in patients with ADPKD. Markers of mineral metabolism were measured in 944 patients with ADPKD and other causes of kidney disease.
      Citation: Kidney International (2020)
      PubDate: 2020-09-10
      DOI: 10.1016/j.kint.2020.07.041
       
  • Human kidney organoids produce functional renin
    • Authors: Anusha S. Shankar; Zhaoyu Du, Hector Tejeda Mora, Thierry P.P. van den Bosch, Sander S. Korevaar, Ingrid M. Van den Berg – Garrelds, Eric Bindels, Carmen Lopez-Iglesias, Marian Clahsen-van Groningen, Joost Gribnau, Carla C. Baan, A.H. Jan Danser, Ewout J. Hoorn, Martin J. Hoogduijn
      Abstract: Renin production by the kidney is of vital importance for salt, volume, and blood pressure homeostasis. The lack of human models hampers investigation into the regulation of renin and its relevance for kidney physiology. To develop such a model, we used human induced pluripotent stem cell derived kidney organoids to study the role of renin and the renin-angiotensin system in the kidney. Extensive characterization of the kidney organoids revealed kidney-specific cell populations consisting of podocytes, proximal and distal tubular cells, stromal cells and endothelial cells.
      Citation: Kidney International (2020)
      PubDate: 2020-09-09
      DOI: 10.1016/j.kint.2020.08.008
       
  • Cystinuria: clinical practice recommendation
    • Authors: Aude Servais; Kay Thomas, Luca Dello Strologo, John A. Sayer, Soumeya Bekri, Aurelia Bertholet-Thomas, Matthew Bultitude, Giovanna Capolongo, Rimante Cerkauskiene, Michel Daudon, Steeve Doizi, Valentine Gillion, Silvia Gràcia-Garcia, Jan Halbritter, Laurence Heidet, Marleen van den Heijkant, Sandrine Lemoine, Bertrand Knebelmann, Francesco Emma, Elena Levtchenko, Metabolic Nephropathy Workgroup of the European Reference Network for Rare Kidney Diseases (ERKNet) eUROGEN
      Abstract: Cystinuria (OMIM 220100) is an autosomal recessive hereditary disorder in which high urinary cystine excretion leads to formation of cystine stones due to its low solubility at normal urinary pH. We developed clinical practice recommendation for diagnosis, surgical and medical treatment, and follow up of cystinuria patients. Elaboration of these Clinical Practice Recommendations spanned from June 2018 until December 2019 with a consensus conference in January 2019. Selected topic areas were chosen by the co-chairs of the conference.
      Citation: Kidney International (2020)
      PubDate: 2020-09-09
      DOI: 10.1016/j.kint.2020.06.035
       
  • Renin-angiotensin aldosterone inhibitor use at hospital discharge among
           patients with moderate to severe acute kidney injury and its association
           with recurrent acute kidney injury and mortality.
    • Authors: Edward D. Siew; Sharidan K. Parr, Khaled Abdel-Kader, Amy M. Perkins, Robert A. Greevy, Andrew J. Vincz, Jason Denton, Otis D. Wilson, Adriana M. Hung, T. Alp Ikizler, Cassianne Robinson-Cohen, Michael E. Matheny
      Abstract: Recurrent episodes of acute kidney injury (AKI) are common among AKI survivors. Renin-angiotensin aldosterone inhibitors (RAASi) are often indicated for these patients but may increase the risk for recurrent AKI. Here, we examined whether RAASi associates with a higher risk for recurrent AKI and mortality among survivors of moderate to severe AKI in a retrospective cohort of Veterans who survived Stage II or III AKI. The primary exposure was RAASi at hospital discharge and the primary endpoint was recurrent AKI within 12 months.
      Citation: Kidney International (2020)
      PubDate: 2020-09-08
      DOI: 10.1016/j.kint.2020.08.022
       
  • Magnetic resonance imaging accurately tracks kidney pathology and
           heterogeneity in the transition from acute kidney injury to chronic kidney
           disease.
    • Authors: Jennifer R. Charlton; Yanzhe Xu, Teresa Wu, Kim A. deRonde, Jillian L. Hughes, Shourik Dutta, Gavin T. Oxley, Aleksandra Cwiek, Helen P. Cathro, Nathan P. Charlton, Mark R. Conaway, Edwin J. Baldelomar, Neda Parvin, Kevin M. Bennett
      Abstract: Acute kidney injury is common in hospitalized patients. Many of the patients who experience AKI develop chronic kidney disease. However, using clinically available tools it is difficult to predict who and when CKD will develop. CFE-MRI provides several measurements of functional glomeruli in preclinical studies. CFE-MRI has the potential to be translated to use in humans, to detect changes in the kidney following acute kidney injury and predict which patients may develop CKD. The next steps toward translation will include in vivo tracking of glomerular fate in preclinical models of AKI to CKD and assessing the toxicity of CF in repeated doses.
      Citation: Kidney International (2020)
      PubDate: 2020-09-08
      DOI: 10.1016/j.kint.2020.08.021
       
  • Prediction modelling - Part 2 - Using machine learning strategies to
           improve transplantation outcomes
    • Authors: Craig Peter Coorey; Ankit Sharma, Samuel Mueller, Jean Yang
      Abstract: Kidney transplant recipients and transplant physicians face important clinical questions where machine learning methods may help improve the decision-making process. This mini-review explores potential applications of machine learning methods to key stages of a kidney transplant recipient’s journey, from initial waitlisting and donor selection, to personalization of immunosuppression and prediction of post-transplantation events. Both unsupervised and supervised machine learning methods are presented, including k-means clustering, principal components analysis, k-nearest neighbors and random forests.
      Citation: Kidney International (2020)
      PubDate: 2020-09-07
      DOI: 10.1016/j.kint.2020.08.026
       
  • A cross sectional study of 502 patients found a diffuse hyperechoic kidney
           medulla pattern in patients with severe gout.
    • Authors: Thomas Bardin; Quang D. Nguyen, Khoy M. Tran, Nghia H. Le, Minh D. Do, Pascal Richette, Emmanuel Letavernier, Jean-Michel Correas, Mathieu Resche-Rigon
      Abstract: We have previously shown that ultrasonography can detect hyperechogenic crystal deposits in the kidney medulla of patients with gout. In this cross-sectional study we investigated the frequency and clinical correlates of hyperechogenic kidney medulla in 502 consecutive primary consultants for gout (ACR/EULAR criteria) at the Vien Gut medical center in Ho Chi Minh City, Vietnam. None of these patients received urate-lowering drugs. Kidney medulla echogenicity on B-mode ultrasonography was compared to that of the kidney cortex.
      Citation: Kidney International (2020)
      PubDate: 2020-09-05
      DOI: 10.1016/j.kint.2020.08.024
       
  • Preoperative Carfilzomib and Lulizumab based desensitization prolongs
           graft survival in a sensitized non-human primate model.
    • Authors: Paul M. Schroder; Robin Schmitz, Zachary W. Fitch, Brian Ezekian, Janghoon Yoon, Ashley Y. Choi, Miriam Manook, Andrew Barbas, Frank Leopardi, Mingqing Song, Alton B. Farris, Bradley Collins, Jean Kwun, Stuart J. Knechtle
      Abstract: Sensitized patients are difficult to transplant due to pre-formed anti-donor immunity. We have previously reported successful desensitization using carfilzomib and belatacept in a non-human primate (NHP) model. Here we evaluated selective blockade of the co-stimulatory signal (CD28-B7) with Lulizumab, which preserves the co-inhibitory signal (CTLA4-B7). Five maximally MHC-mismatched pairs of NHPs were sensitized to each other with two sequential skin transplants. Individuals from each pair were randomized to either desensitization with once-weekly Carfilzomib (27mg/m2 IV) and Lulizumab (12.5mg/kg SC) over four weeks, or no desensitization (Control).
      Citation: Kidney International (2020)
      PubDate: 2020-09-05
      DOI: 10.1016/j.kint.2020.08.020
       
  • Multifactorial intervention has a significant effect on diabetic kidney
           disease in patients with type 2 diabetes.
    • Authors: Kohjiro Ueki; Takayoshi Sasako, Yukiko Okazaki, Kana Miyake, Masaomi Nangaku, Yasuo Ohashi, Mitsuhiko Noda, Takashi Kadowaki, J-DOIT3 Study Group
      Abstract: To evaluate the effect of multifactorial intervention on the onset and progression of diabetic kidney disease in the patients with type 2 diabetes, we analyzed the effects of intensified multifactorial intervention (intensive therapy treatment targets; HbA1c under 6.2%, blood pressure under 120/75 mmHg, low-density lipoprotein cholesterol under 80 mg/dL) comparing with step-wise intensification of medications and life-style modifications of guideline-based standard care (conventional therapy treatment targets: HbA1c under 6.9%, blood pressure under 130/80 mmHg, low-density lipoprotein cholesterol under 120 mg/dL) on diabetic kidney disease.
      Citation: Kidney International (2020)
      PubDate: 2020-09-03
      DOI: 10.1016/j.kint.2020.08.012
       
  • Time-dependent lymphocyte count after transplantation is associated with
           higher risk of graft failure and death.
    • Authors: Amaury Dujardin; Marine Lorent, Yohann Foucher, Christophe Legendre, Clarisse Kerleau, Sophie Brouard, Magali Giral, DIVAT consortium
      Abstract: The transplantation field requires the identification of specific risk factors associated with the level of immunosuppression. Here, our aim was to analyze the association between the number of circulating lymphocytes, monitored routinely by complete blood cell counts during outpatient visits, and patient and graft survival. In total, 2,999 kidney or combined kidney-pancreas recipients transplanted between 2000 and 2016, from two University hospitals, were enrolled. We investigated the etiological relationship between time-dependent lymphocyte count beyond one year after transplantation and patient and graft survival, viral infection and cancer risk using time-dependent multivariate Cox models.
      Citation: Kidney International (2020)
      PubDate: 2020-09-03
      DOI: 10.1016/j.kint.2020.08.010
       
  • Development and testing of an artificial intelligence tool for predicting
           end stage kidney disease in patients with immunoglobulin A nephropathy.
    • Authors: Francesco Paolo Schena; Vito Walter Anelli, Joseph Trotta, Tommaso Di Noia, Carlo Manno, Giovanni Tripepi, Graziella D’Arrigo, Nicholas C. Chesnaye, Maria Luisa Russo, Maria Stangou, Aikaterini Papagianni, Carmine Zoccali, Vladimir Tesar, Rosanna Coppo
      Abstract: We have developed an artificial neural network prediction model for end-stage kidney disease (ESKD) in patients with primary immunoglobulin A nephropathy (IgAN) using a retrospective cohort of 948 patients with IgAN. Our tool is based on a two-step procedure of a classifier model that predicts ESRD, and a regression model that predicts development of ESKD over time. The classifier model showed a performance value of 0.82 (area under the receiver operating characteristic curve) in patients with a follow-up of five years, which improved to 0.89 at the ten-year follow-up.
      Citation: Kidney International (2020)
      PubDate: 2020-09-01
      DOI: 10.1016/j.kint.2020.07.046
       
  • HLA-D and PLA2R1 risk alleles associate with recurrent primary membranous
           nephropathy in kidney transplant recipients.
    • Authors: Lena Berchtold; Eric Letouzé, Mariam Priya Alexander, Guillaume Canaud, Anne-Els van de Logt, Patrick Hamilton, Christiane Mousson, Vincent Vuiblet, Ann M. Moyer, Sylvain Guibert, Petra Mrázová, Charlène Levi, Valérie Dubois, Josep Maria Cruzado, Armando Torres, Manish J. Gandhi, Nadhir Yousfi, Vladimir Tesar, Ondrej Viklický, Maryvonne Hourmant, Bruno Moulin, Philippe Rieu, Gabriel Choukroun, Christophe Legendre, Jack Wetzels, Paul Brenchley, José Aurelio Ballarín Castan, Hanna Debiec, Pierre Ronco
      Abstract: Recurrence of primary membranous nephropathy after transplantation occurs in up to 44% of patients and is driven by PLA2R antibody. Here, we asked whether genetic determinants could improve risk prediction. First, we sequenced PLA2R1 and HLA-D loci in 248 patients with primary membranous nephropathy and identified two independent single nucleotide polymorphisms (SNPs) at risk for primary membranous nephropathy at each locus. These were rs9271188 (intergenic between HLA-DRB1 and HLA-DQA1,) and rs9275086 (intergenic between HLA-DQB1 and HLA-DQA2) at the HLA-D locus along with rs6726925 and rs13018963 at the PLA2R1 locus.
      Citation: Kidney International (2020)
      PubDate: 2020-09-01
      DOI: 10.1016/j.kint.2020.08.007
       
  • Impaired angiotensin II type 1 receptor signaling contributes to sepsis
           induced acute kidney injury.
    • Authors: Daniel E. Leisman; Tiago D. Fernandes, Vanesa Bijol, Mabel N. Abraham, Jake R. Lehman, Matthew D. Taylor, Christine Capone, Omar Yaipan, Rinaldo Bellomo, Clifford S. Deutschman
      Abstract: In sepsis-induced acute kidney injury, kidney blood flow may increase despite decreased glomerular filtration. Normally, angiotensin-II reduces kidney blood flow to maintain filtration. We hypothesized that sepsis reduces angiotensin type-1 receptor (AT1R) expression to account for this observation and tested this hypothesis in a patient case-control study and studies in mice. Seventy-three mice underwent cecal ligation and puncture (a sepsis model) or sham operation. Additionally, 94 septic mice received losartan (selective AT1R antagonist), angiotensin II without or with losartan, or vehicle.
      Citation: Kidney International (2020)
      PubDate: 2020-08-31
      DOI: 10.1016/j.kint.2020.07.047
       
  • Management of idiopathic childhood nephrotic syndrome in Sub-Saharan
           Africa: Ibadan consensus statement
    • Authors: Christopher Esezobor; Adebowale D. Ademola, Adewale E. Adetunji, Emmanuel Ademola Anigilaje, Anthony Batte, Fatima Nma Jiya Bello, Francis Fredrick Furia, Uzoamaka Muoneke, Mignon McCulloch, Peter Nourse, Patience Obiagwu, Odutola Odetunde, Perditer Okyere, Adaobi Solarin, Elliot Koranteng Tannor, Damien Noone, Rasheed Gbadegesin, Rulan S. Parekh, H3 Africa Kidney Disease Research Network
      Abstract: In sub-Saharan Africa, glomerular disease, specifically nephrotic syndrome (NS), is the leading cause of chronic kidney disease (CKD) and end-stage kidney disease (ESKD) in children.1-3 Prevalence of NS is estimated at 2-7 per 100,000 children worldwide,1 and it is one of the more common causes of pediatric kidney disorders in Africa. Despite limited reports from Nigeria and Sudan, 2-4 the overall incidence of NS in Africa is unknown. Among the 54 African countries, only 17 have information on the burden of childhood NS indicating substantial underreporting.
      Citation: Kidney International (2020)
      PubDate: 2020-08-28
      DOI: 10.1016/j.kint.2020.07.045
       
  • A non-biodegradable scaffold-free cell sheet of genome-engineered
           mesenchymal stem cells inhibits development of acute kidney injury.
    • Authors: Hye-Jeong Park; Min Jung Kong, Hyo-Ju Jang, Jeong-In Cho, Eui-Jung Park, In-Kyu Lee, Jørgen Frøkiær, Rikke Norregaard, Kwon Moo Park, Tae-Hwan Kwon
      Abstract: Cell therapy using genome-engineered stem cells has emerged as a novel strategy for the treatment of kidney diseases. By exploiting genome editing technology, human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) secreting an angiogenic factors or an anti-inflammatory factor were generated for therapeutic application in acute kidney injury. Junction polymerase chain reaction analysis verified Zinc Finger Nucleases-assisted integration of the desired gene into the hUC-MSCs. Flow cytometry and differentiation assays indicated that genome editing did not affect the differentiation potential of these mesenchymal stem cells.
      Citation: Kidney International (2020)
      PubDate: 2020-08-24
      DOI: 10.1016/j.kint.2020.07.043
       
  • Development and evaluation of deep learning-based segmentation of
           histologic structures in the kidney cortex with multiple histologic
           stains.
    • Authors: Catherine P. Jayapandian; Yijiang Chen, Andrew R. Janowczyk, Matthew B. Palmer, Clarissa A. Cassol, Miroslav Sekulic, Jeffrey B. Hodgin, Jarcy Zee, Stephen M. Hewitt, John O’Toole, Paula Toro, John R. Sedor, Laura Barisoni, Anant Madabhushi
      Abstract: The application of deep learning for automated segmentation (delineation of boundaries) of histologic primitives (structures) from whole slide images can facilitate the establishment of novel protocols for kidney biopsy assessment. Here, we developed and validated deep learning networks for the segmentation of histologic structures on kidney biopsies and nephrectomies. For development, we examined 125 biopsies for Minimal Change Disease collected across 29 NEPTUNE enrolling centers along with 459 whole slide images stained with Hematoxylin & Eosin (125), Periodic Acid Schiff (125), Silver (102), and Trichrome (107)] divided into training, validation and testing sets (ratio 6:1:3).
      Citation: Kidney International (2020)
      PubDate: 2020-08-21
      DOI: 10.1016/j.kint.2020.07.044
       
  • Automated total kidney volume measurements in pre-clinical magnetic
           resonance imaging for resourcing imaging data, annotations, and source
           code
    • Authors: Marie E. Edwards; Sigapriya Periyanan, Deema Anaam, Adriana V. Gregory, Timothy L. Kline
      Abstract: The objective of this study was to validate a fully automated total kidney volume measurement method for pre-clinical rodent trials that is fast, accurate, reproducible, and to provide these resources to the research community. Rodent studies that involve imaging are crucial for monitoring treatment efficacy in diseases such as polycystic kidney disease. Previous studies utilize manual or semi-automated segmentations, which are time consuming and potentially biased. To develop our automated system, a total of 150 axial magnetic resonance images (MRI) from a variety of mouse models were manually segmented and used to train/validate an automated algorithm.
      Citation: Kidney International (2020)
      PubDate: 2020-08-20
      DOI: 10.1016/j.kint.2020.07.040
       
  • NELL1 is a target antigen in malignancy-associated membranous nephropathy
    • Authors: Tiffany Caza; Samar Hassen, Zeljko Dvanajscak, Michael Kuperman, Rick Edmondson, Christian Herzog, Aaron Storey, John Arthur, L. Nicholas Cossey, Shree Sharma, Daniel Kenan, Christopher Larsen
      Abstract: Patients with membranous nephropathy have an increased risk of malignancy compared to the general population, but the target antigen for malignancy-associated membranous nephropathy is unknown. To explore this, we utilized mass spectrometry for antigen discovery in malignancy-associated membranous nephropathy examining immune complexes eluted from frozen kidney biopsy tissue using protein G bead immunoglobulin capture. Antigen discovery was performed comparing cases of membranous nephropathy of unknown and known type.
      Citation: Kidney International (2020)
      PubDate: 2020-08-19
      DOI: 10.1016/j.kint.2020.07.039
       
  • Statins, obesity, and the microbiome: A potential mechanism for the
           pleiotropic effects of statin therapy
    • Authors: Martin Reichel; Felix Knauf
      Abstract: Statins are the most commonly prescribed oral agents for lipid-lowering therapy. The drugs have a proven survival benefit when used as primary or secondary cardiovascular disease prevention over a wide range of baseline low density lipoprotein cholesterol (LDL-C) levels. Statins competitively inhibit hydroxymethyl-glutaryl CoA reductase (HMG-CoA reductase), the rate-limiting step in cholesterol biosynthesis. However, the exact mechanism(s) of clinical benefit with statins are incompletely understood.
      Citation: Kidney International (2020)
      PubDate: 2020-08-18
      DOI: 10.1016/j.kint.2020.07.038
       
  • Immunotactoid glomerulopathy is a rare entity with monoclonal and
           polyclonal variants.
    • Authors: Samih H. Nasr; Satoru S. Kudose, Samar M. Said, Dominick Santoriello, Mary E. Fidler, Sean R. Williamson, Sibel Erdogan Damgard, Sanjeev Sethi, Nelson Leung, Vivette D. D’Agati, Glen S. Markowitz
      Abstract: Immunotactoid glomerulopathy (ITG) is a rare form of glomerulonephritis for which our understanding is limited to case reports and small case series. Herein we describe the clinical, pathologic, and outcome characteristics of 73 patients with ITG who typically presented with proteinuria, hematuria, and renal insufficiency. Hematologic disorders were present in 66% of patients, including lymphoma in 41% (mainly chronic lymphocytic leukemia/small lymphocytic lymphoma), monoclonal gammopathy in 20%, and multiple myeloma in 6%.
      Citation: Kidney International (2020)
      PubDate: 2020-08-17
      DOI: 10.1016/j.kint.2020.07.037
       
  • Genetic or Pharmacologic Nrf2 Activation Increases Proteinuria in Chronic
           Kidney Disease in Mice
    • Authors: Brittney M. Rush; Corry D. Bondi, Sean D. Stocker, Kacie M. Barry, Sarah A. Small, Jason Ong, Soma Jobbagy, Donna B. Stolz, Sheldon I. Bastacky, Dionysios V. Chartoumpekis, Thomas W. Kensler, Roderick J. Tan
      Abstract: The nuclear factor erythroid 2 related factor 2 (Nrf2) pathway upregulates key cellular defenses. Clinical trials are utilizing pharmacologic Nrf2 inducers such as bardoxolone methyl to treat chronic kidney disease, but Nrf2 activation has been linked to a paradoxical increase in; proteinuria. To understand this effect, we examined genetically engineered mice with elevatedNrf2 signaling due to reduced expression of the Nrf2 inhibitor, Kelch-like ECH-associated protein-1 (Keap1). These Keap1FA/FA mice lacked baseline proteinuria but exhibited increased; proteinuria in experimental models evoked by adriamycin, angiotensin II, or protein overload.
      Citation: Kidney International (2020)
      PubDate: 2020-08-17
      DOI: 10.1016/j.kint.2020.07.036
       
  • A practical guide to multiple imputation of missing data in nephrology
    • Authors: Katrina Blazek; Anita van Zwieten, Valeria Saglimbene, Armando Teixeira-Pinto
      Abstract: Health data are often plagued with missing values which can greatly reduce the sample size if only complete cases are considered for analysis. Furthermore, analyses which ignore the missing data have the potential to introduce bias in the parameter estimates. Multiple imputation techniques have been developed to recover the information that would otherwise be lost when excluding observations with missing data and to help minimise bias. However, the validity of analyses using imputed data relies on the imputation model having been correctly specified.
      Citation: Kidney International (2020)
      PubDate: 2020-08-17
      DOI: 10.1016/j.kint.2020.07.035
       
  • A systematic review and participant-level meta-analysis found little
           
    • Authors: Weng Kit Lye; Euan Paterson, Christopher C. Patterson, Alexander P. Maxwell, Riswana Banu Binte Mohammed Abdul, E Shyong Tai, Ching Yu Cheng, Takamasa Kayama, Hidetoshi Yamashita, Mark Sarnak, Michael Shlipak, Kunihiro Matsushita, Unal Mutlu, Mohammad A. Ikram, Caroline Klaver, Annette Kifley, Paul Mitchell, Chelsea Myers, Barbara E. Klein, Ronald Klein, Tien Y. Wong, Charumathi Sabanayagam, Gareth J. McKay
      Abstract: Previously, variation in retinal vascular caliber has been reported in association with chronic kidney disease (CKD) but findings remain inconsistent. To help clarify this we conducted individual participant data meta-analysis and aggregate data meta-analysis on summary estimates to evaluate cross-sectional associations between retinal vascular caliber and CKD. A systematic review was performed using Medline and EMBASE for articles published until October 2018. The aggregate analysis used a two-stage approach combining summary estimates from eleven studies (44,803 patients) while the individual participant analysis used a one-stage approach combining raw data from nine studies (33,222 patients).
      Citation: Kidney International (2020)
      PubDate: 2020-08-15
      DOI: 10.1016/j.kint.2020.06.033
       
  • Trajectories of glomerular filtration rate and progression to end stage
           kidney disease after kidney transplantation.
    • Authors: Marc Raynaud; Olivier Aubert, Peter P. Reese, Yassine Bouatou, Maarten Naesens, Nassim Kamar, Élodie Bailly, Magali Giral, Marc Ladrière, Moglie Le Quintrec, Michel Delahousse, Ivana Juric, Nikolina Basic-Jukic, Gaurav Gupta, Enver Akalin, Chen-Shan Chin, Cécile Proust-Lima, Georg Böhmig, Rainer Oberbauer, Mark D. Stegall, Andrew J. Bentall, Stanley C. Jordan, Edmund Huang, Denis Glotz, Christophe Legendre, Robert A. Montgomery, Dorry L. Segev, Jean-Philippe Empana, Morgan E. Grams, Josef Coresh, Xavier Jouven, Carmen Lefaucheur, Alexandre Loupy
      Abstract: Although the gold standard of monitoring kidney transplant function relies on glomerular filtration rate (GFR), little is known about GFR trajectories after transplantation, their determinants, and their association with outcomes. To evaluate these parameters we examined kidney transplant recipients receiving care at 15 academic centers. Patients underwent prospective monitoring of estimated GFR (eGFR) measurements, with assessment of clinical, functional, histological and immunological parameters.
      Citation: Kidney International (2020)
      PubDate: 2020-08-08
      DOI: 10.1016/j.kint.2020.07.025
       
  • Amniotic fluid peptides predict postnatal kidney survival in developmental
           kidney disease.
    • Authors: Julie Klein; Bénédicte Buffin-Meyer, Franck Boizard, Nabila Moussaoui, Ophélie Lescat, Benjamin Breuil, Camille Fedou, Guylène Feuillet, Audrey Casemayou, Eric Neau, An Hindryckx, Luc Decatte, Elena Levtchenko, Anke Raaijmakers, Christophe Vayssière, Valérie Goua, Charlotte Lucas, Franck Perrotin, Sylvie Cloarec, Alexandra Benachi, Marie-Christine Manca-Pellissier, Hélène Laurichesse Delmas, Lucie Bessenay, Claudine Le Vaillant, Emma Allain-Launay, Jean Gondry, Bernard Boudailliez, Elisabeth Simon, Fabienne Prieur, Marie-Pierre Lavocat, Anne-Hélène Saliou, Loic De Parscau, Laurent Bidat, Catherine Noel, Corinne Floch, Guylène Bourdat-Michel, Romain Favre, Anne-Sophie Weingertner, Jean-François Oury, Véronique Baudouin, Jean-Paul Bory, Christine Pietrement, Maryse Fiorenza, Jérôme Massardier, Sylvie Kessler, Nadia Lounis, Françoise Conte Auriol, Pascale Marcorelles, Sophie Collardeau-Frachon, Petra Zürbig, Harald Mischak, Pedro Magalhães, Julie Batut, Patrick Blader, Jean-Sebastien Saulnier Blache, Jean-Loup Bascands, Franz Schaefer, Stéphane Decramer, Joost P. Schanstra, BIOMAN consortium
      Abstract: Although a rare disease, bilateral congenital anomalies of the kidney and urinary tract (CAKUT) are the leading cause of end stage kidney disease in children. Ultrasound-based prenatal prediction of postnatal kidney survival in CAKUT pregnancies is far from accurate. To improve prediction, we conducted a prospective multicenter peptidome analysis of amniotic fluid spanning 140 evaluable fetuses with CAKUT. We identified a signature of 98 endogenous amniotic fluid peptides, mainly composed of fragments from extracellular matrix proteins and from the actin binding protein thymosin-β4.
      Citation: Kidney International (2020)
      PubDate: 2020-08-01
      DOI: 10.1016/j.kint.2020.06.043
       
  • Simultaneous Glomerular Filtration Rate Determination Using Inulin,
           Iohexol and 99mTc-DTPA Demonstrates the Need for Customized Measurement
           Protocols
    • Authors: Christine A. White; Ayub Akbari, Celine Allen, Andrew G. Day, Patrick A. Norman, David Holland, Michael A. Adams, Greg A. Knoll
      Abstract: Urinary inulin clearance is considered the gold standard of glomerular filtration rate (GFR)measurement but plasma clearance of less expensive and more accessible tracers is more commonly performed. Many plasma sampling protocols exist but little is known about their accuracy. Here, the study objectives were to compare plasma iohexol and 99mTc-DTPA GFR with varying sampling strategies to the GFR measured by urinary inulin and to identify protocols with the greatest accuracy according to clinical characteristics.
      Citation: Kidney International (2020)
      PubDate: 2020-07-31
      DOI: 10.1016/j.kint.2020.06.044
       
  • Results of a nation-wide cohort study suggest favorable long-term outcomes
           of clone-targeted chemotherapy in immunotactoid glomerulopathy.
    • Authors: Vincent Javaugue; Léa Dufour-Nourigat, Estelle Desport, Audrey Sibille, Bruno Moulin, Pierre Bataille, Pascal Bindi, Cyril Garrouste, Christophe Mariat, Lionel Karlin, Mathilde Nouvier, Jean-Michel Goujon, Viviane Gnemmi, Jean-Paul Fermand, Guy Touchard, Frank Bridoux
      Abstract: Immunotactoid glomerulopathy is a rare disease defined by glomerular microtubular immunoglobulin deposits. Since management and long-term outcomes remain poorly described, we retrospectively analyzed results of 27 adults from 21 departments of nephrology in France accrued over19 years. Inclusion criteria were presence of glomerular Congo red-negative monotypic immunoglobulin deposits with ultrastructural microtubular organization, without evidence for cryoglobulinemic glomerulonephritis. Baseline manifestations of this cohort included: proteinuria (median 6.0 g/day), nephrotic syndrome (70%), microscopic hematuria (74%) and hypertension (56%) with a median serum creatinine of 1.5 mg/dL.
      Citation: Kidney International (2020)
      PubDate: 2020-07-30
      DOI: 10.1016/j.kint.2020.06.039
       
  • Spot urinary citrate-to-creatinine ratio is a marker for acid-base status
           in chronic kidney disease.
    • Authors: Fabiola G. Gianella; Victor E. Prado, John R. Poindexter, Beverley Adams-Huet, Xilong Li, R. Tyler Miller, Khashayar Sakhaee, Naim M. Maalouf, Orson W. Moe
      Abstract: Due to multiple compensating mechanisms, the serum bicarbonate concentration is a relatively insensitive marker of acid-base status; especially in chronic kidney disease (CKD). This is a major drawback that impairs the ability to diagnose acid excess or monitor alkali therapy. We postulated that it is more logical to measure the compensatory defense mechanism(s) rather than the defended parameter, which remains normal if the compensation is successful. Therefore, a retrospective cross-sectional study was performed in 1733 stone formers along with a prospective cross-sectional study of 22 individuals with normal kidney function and 50 patients in different stages of CKD.
      Citation: Kidney International (2020)
      PubDate: 2020-07-25
      DOI: 10.1016/j.kint.2020.07.006
       
  • Results from the TRIBE-AKI Study found associations between post-operative
           
    • Authors: Steven Menez; Dennis G. Moledina, Amit X. Garg, Heather Thiessen-Philbrook, Eric McArthur, Yaqi Jia, Caroline Liu, Wassim Obeid, Sherry G. Mansour, Jay L. Koyner, Michael G. Shlipak, Francis P. Wilson, Steven G. Coca, Chirag R. Parikh
      Abstract: Patients undergoing cardiac surgery are placed under intense physiologic stress. Blood and urine biomarkers measured peri-operatively may help identify patients at higher risk for adverse long-term kidney outcomes.We sought to determine independent associations of various biomarkers with development or progression of chronic kidney disease (CKD) following cardiac surgery. In this sub-study of the prospective cohort –TRIBE-AKI Study, we evaluated 613 adult patients undergoing cardiac surgery in Canada in our primary analysis and tested the association of 40 blood and urinary biomarkers with the primary composite outcome of CKD incidence or progression.
      Citation: Kidney International (2020)
      PubDate: 2020-07-25
      DOI: 10.1016/j.kint.2020.06.037
       
  • A profile of multiple circulating tumor necrosis factor receptors
           associated with early progressive kidney decline in Type 1 Diabetes is
           similar to profiles in autoimmune disorders.
    • Authors: Katsuhito Ihara; Jan Skupien, Bozena Krolewski, Zaipul I. Md Dom, Kristina O’Neil, Eiichiro Satake, Hiroki Kobayashi, Narges M. Rashidi, Monika A. Niewczas, Andrzej S. Krolewski
      Abstract: This study comprehensively evaluated the association between known circulating tumor necrosis factor (TNF) superfamily ligands and receptors and the development of early progressive kidney decline (PKD) leading to end-stage kidney disease (ESKD) in Type 1 diabetes. Participants for the study were from the Macro-Albuminuria Study (198 individuals), and the Micro-Albuminuria Study (148 individuals) of the Joslin Kidney Study. All individuals initially had normal kidney function and were followed for seven-fifteen years to determine the slope of the estimate glomerular filtration rate and to ascertain onset of ESKD.
      Citation: Kidney International (2020)
      PubDate: 2020-07-24
      DOI: 10.1016/j.kint.2020.07.007
       
  • A study from The Mayo Clinic evaluated long-term outcomes of kidney
           transplantation in patients with immunoglobulin light chain amyloidosis.
    • Authors: Cihan Heybeli; Andrew Bentall, Jiqiu Wen, Mariam Priya Alexander, Francis K. Buadi, Fernando Cosio, Patrick G. Dean, Angela Dispenzieri, David Dingli, Mireille El Ters, Morie A. Gertz, Amer Hatem, Prashant Kapoor, Hasan Khamash, Taxiarchis Kourelis, Shaji Kumar, Elizabeth Lorenz, Martin Mai, Eli Muchtar, David Murray, Mikel Prieto, Carrie Schinstock, Mark Stegall, Rahma Warsame, Nelson Leung
      Abstract: Longer survival using modern therapies has increased the number of patients with immunoglobulin light-chain amyloidosis receiving kidney transplantation. We evaluated 60 patients with immunoglobulin light chain amyloidosis who underwent kidney transplantation based on their hematologic response for outcomes of death, graft failure, and complications. Patient hematologic responses (light-chain in blood or urine) prior to kidney transplantation were three patients had no response, five had a partial response, six had a very good partial response, 37 had a complete response, and nine were treatment-naive patients (never treated for this disorder).
      Citation: Kidney International (2020)
      PubDate: 2020-07-23
      DOI: 10.1016/j.kint.2020.06.036
       
  • Fumarate modulates phospholipase A2 receptor autoimmunity-induced podocyte
           injury in membranous nephropathy.
    • Authors: Hyung Ah Jo; Jin Seong Hyeon, Seung Hee Yang, Youngae Jung, Hunjoo Ha, Chang Wook Jeong, Cheol Kwak, Yaerim Kim, Hajeong Lee, Jung Pyo Lee, Kwon Wook Joo, Chun Soo Lim, Yon Su Kim, Geum-Sook Hwang, Dong Ki Kim
      Abstract: Downstream mechanisms that lead to podocyte injury following phospholipase A2 receptor (PLA2R) autoimmunity remain elusive. To help define this we compared urinary metabolomic profiles of patients with PLA2R-associated membranous nephropathy (MN) at the time of kidney biopsy with those of patients with minimal change disease (MCD) and to healthy individuals. Among the metabolites differentially expressed in patients with PLA2R-associated MN compared to healthy individuals, fumarate was the only significant differentially expressed metabolite in PLA2R-associated MN compared to MCD [fold-difference vs.
      Citation: Kidney International (2020)
      PubDate: 2020-07-23
      DOI: 10.1016/j.kint.2020.06.031
       
  • A prospective cohort study that examined acute kidney injury and kidney
           outcomes, cardiovascular events and death informs on long-term clinical
           outcomes.
    • Authors: T. Alp Ikizler; Chirag R. Parikh, Jonathan Himmelfarb, Vernon M. Chinchilli, Kathleen D. Liu, Steven G. Coca, Amit X. Garg, Chi-yuan Hsu, Edward D. Siew, Mark M. Wurfel, Lorraine B. Ware, Georgia Brown Faulkner, Thida C. Tan, James S. Kaufman, Paul L. Kimmel, Alan S. Go, ASSESS-AKI Study Investigators
      Abstract: Acute kidney injury (AKI) has been reported to be associated with excess risks of death, kidney disease progression and cardiovascular events although previous studies have important limitations. To further examine this, we prospectively studied adults from four clinical centers surviving three months and more after hospitalization with or without AKI who were matched on center, pre-admission CKD status, and an integrated priority score based on age, prior cardiovascular disease or diabetes mellitus, preadmission estimated glomerular filtration rate (eGFR) and treatment in the intensive care unit during the index hospitalization between December 2009-February 2015, with follow-up through November 2018.
      Citation: Kidney International (2020)
      PubDate: 2020-07-21
      DOI: 10.1016/j.kint.2020.06.032
       
  • The clinicopathologic spectrum of segmental membranous glomerulopathy.
    • Authors: Satoru Kudose; Dominick Santoriello, Hanna Debiec, Pietro A. Canetta, Andrew S. Bomback, M. Barry Stokes, Ibrahim Batal, Pierre Ronco, Vivette D. D’Agati, Glen S. Markowitz
      Abstract: Membranous glomerulopathy (MGN) is characterized by global subepithelial immune deposits that stain most intensely by immunofluorescence for IgG. Here we describe the clinical and pathologic findings in a cohort of patients with MGN in which, by definition, only segmental immune deposits are present. This rare variant, termed segmental MGN (sMGN), is poorly characterized. We retrospectively identified all patients with sMGN diagnosed at Columbia University from January 2010 to October 2018, excluding those with systemic lupus erythematosus.
      Citation: Kidney International (2020)
      PubDate: 2020-06-26
      DOI: 10.1016/j.kint.2020.06.014
       
  • Nuclear antigen-reactive CD4+ T cells expand in active systemic lupus
           erythematosus, produce effector cytokines, and invade the kidneys.
    • Authors: Dimas Abdirama; Sebastian Tesch, Anna-Sophie Grießbach, Caroline von Spee-Mayer, Jens Y. Humrich, Ulrik Stervbo, Nina Babel, Christian Meisel, Tobias Alexander, Robert Biesen, Petra Bacher, Alexander Scheffold, Kai-Uwe Eckardt, Falk Hiepe, Andreas Radbruch, Gerd-Rüdiger Burmester, Gabriela Riemekasten, Philipp Enghard
      Abstract: Systemic lupus erythematosus is a systemic and chronic autoimmune disease characterized by loss of tolerance towards nuclear antigens with autoreactive CD4+ T cells implicated in disease pathogenesis. However, very little is known about their receptor specificity since the detection of human autoantigen specific CD4+ T cells has been extremely challenging. Here we present an analysis of CD4+ T cells reactive to nuclear antigens using two complementary methods: T cell libraries and antigen-reactive T cell enrichment.
      Citation: Kidney International (2020)
      PubDate: 2020-06-24
      DOI: 10.1016/j.kint.2020.05.051
       
  • Sepsis-Associated Acute Kidney Injury: Is COVID-19 different'
    • Authors: John A. Kellum; Mitra K. Nadim, Lui G. Forni
      First page: 1370
      Abstract: Faced with a new disease, clinicians understandably resort to what they know. For example, we know severe viral pneumonia secondary to influenza, so when we began seeing COVID-19, our first impression was that it was a similar disease, so we felt we knew how to manage it. However, it soon became clear that COVID-19 was strikingly different. First, there was the high transmission rate including spread within hospitals and health care workers 1—but this could simply have been due to a new disease in a naïve population.
      Citation: Kidney International (2020)
      PubDate: 2020-09-09
      DOI: 10.1016/j.kint.2020.08.009
       
  • APOL1 variant associated kidney disease: From trypanosomes to podocyte
           cytoskeleton.
    • Authors: Etienne Pays
      First page: 1373
      Abstract: Expression of the C-terminal APOL1 variants G1 and G2 is strongly linked to chronic kidney disease. The recent analysis of podocytes genetically engineered to express either C-terminal truncated APOL1 or disrupted APOL3 allowed the conclusion that C-terminal APOL1 variants induce reorganization of actomyosin activities through inhibition of APOL3 functions. This editorial is not intended to review the literature in the field, but rather to discuss the proposal that podocyte dysfunctions linked to APOL3 inactivation can account for chronic kidney disease linked to expression of the APOL1 risk variants G1 and G2.
      Citation: Kidney International (2020)
      PubDate: 2020-08-21
      DOI: 10.1016/j.kint.2020.07.034
       
  • Surveying the Human Single Cell Landscape
    • Authors: Haikuo Li; Benjamin D. Humphreys
      First page: 1385
      Abstract: Refers to: Han X, Zhou Z, Fei L, et al. Construction of a human cell landscape at single-cell level. Nature. 2020;581(October 2018). doi:10.1038/s41586-020-2157-4
      Citation: Kidney International (2020)
      PubDate: 2020-07-14
      DOI: 10.1016/j.kint.2020.06.027
       
  • More reasons to use SGLT2 inhibitors: EMPEROR-Reduced and DAPA-CKD
    • Authors: Masaomi Nangaku
      First page: 1387
      Abstract: Refers to:
      Citation: Kidney International (2020)
      PubDate: 2020-10-14
       
  • COVID-19 in Dialysis Patients: Outlasting and Outsmarting a Pandemic
    • Authors: Caroline M. Hsu; Daniel E. Weiner
      First page: 1402
      Abstract: COVID-19 has affected dialysis patients and dialysis patient care worldwide. In this issue of Kidney International, three reports highlight the disproportionately severe impact of COVID-19 on dialysis patients, noting its high prevalence, particularly among in-center dialysis patients. This likely reflects patients’ limited ability to physically distance as well as community exposures, including residence in areas with high rates of infection. Dialysis patients are at extremely high risk should they develop COVID-19, with short-term mortality of 20% or higher.
      Citation: Kidney International (2020)
      PubDate: 2020-10-13
       
  • A Kidney International “Journal of the COVID-19 Year” in
           Kidney Transplantation
    • Authors: P. Toby Coates
      First page: 1404
      Abstract: The global COVID-19 pandemic’s impact on kidney transplant recipients and transplantation programs in the calamitous months of February to June 2020, the Northern Hemisphere Spring to Summer, is represented in articles published in the December issue of Kidney International. Writing about another pandemic in the year of 1665 over 300 years ago the author Daniel Defoe describes the same period of time in London and gives a remarkably familiar description of how a pandemic affects populations, including the unproven treatments, epidemiology of infection and human response to restrictions on freedom of city lockdowns that occurred during that time (1).
      Citation: Kidney International (2020)
      PubDate: 2020-10-19
       
  • Ethics of kidney care in the era of COVID-19
    • Authors: Dominique E. Martin; Jordan A. Parsons, Fergus Caskey, David C.H. Harris, Vivekanand Jha
      First page: 1424
      Abstract: The COVID-19 pandemic presents significant challenges for health systems globally, including substantive ethical dilemmas that may pose specific concerns in the context of care for people with kidney disease. Ethical concerns may arise as changes to policy and practice impact on the ability of all health professionals to fulfil their ethical duties towards their patients in providing best practice care. In this paper we briefly describe such concerns and elaborate on issues of particular ethical complexity in kidney care: equitable access to dialysis during pandemic surges; balancing the risks and benefits of different kidney failure treatments, specifically with regards to suspending kidney transplantation programs and prioritizing home dialysis, and barriers to shared-decision making; and ensuring ethical practice when using unproven interventions.
      Citation: Kidney International (2020)
      PubDate: 2020-10-07
      DOI: 10.1016/j.kint.2020.09.014
       
  • A RECIPROCAL REGULATION OF SPERMIDINE AND AUTOPHAGY IN PODOCYTES MAINTAINS
           THE FILTRATION BARRIER
    • Authors: Wei Liang; Kosuke Yamahara, Camila Hernando-Erhard, Simon Lagies, Nicola Wanner, Huan Liang, Christoph Schell, Bernd Kammerer, Tobias B. Huber, Tillmann Bork
      First page: 1434
      Abstract: Podocyte maintenance and stress resistance are exquisitely based on high basal rates of autophagy making these cells a unique model to unravel mechanisms of autophagy regulation. Polyamines have key cellular functions such as proliferation, nucleic acid biosynthesis and autophagy. Here we test whether endogenous spermidine signaling is a driver of basal and dynamic autophagy in podocytes by using genetic and pharmacologic approaches to interfere with different steps of polyamine metabolism. Translational studies revealed altered spermidine signaling in focal segmental glomerulosclerosis in vivo and in vitro.
      Citation: Kidney International (2020)
      PubDate: 2020-06-27
      DOI: 10.1016/j.kint.2020.06.016
       
  • Secretion of the epithelial sodium channel chaperone PCSK9 from the
           cortical collecting duct links sodium retention with hypercholesterolemia
           in nephrotic syndrome.
    • Authors: Eduardo Molina-Jijon; Stéphanie Gambut, Camille Macé, Carmen Avila-Casado, Lionel C. Clement
      First page: 1449
      Abstract: The proprotein PCSK9 functions as a chaperone for the epithelial sodium channel in the cortical collecting duct (CCD), is highly expressed in the liver, and plays a significant role in the pathogenesis of hypercholesterolemia. Lower levels of PCSK9 expression also occur in the normal kidney and intestine. Here, we found increased PCSK9 expression in the CCD of biopsies of patients with primary glomerular disease and explored a possible relationship with hypercholesterolemia of nephrotic syndrome.
      Citation: Kidney International (2020)
      PubDate: 2020-08-01
      DOI: 10.1016/j.kint.2020.06.045
       
  • A molecular circadian clock operates in the parathyroid gland and is
           
    • Authors: Søren Egstrand; Anders Nordholm, Marya Morevati, Maria Lerche Mace, Alia Hassan, Tally Naveh-Many, Jakob L. Rukov, Eva Gravesen, Klaus Olgaard, Ewa Lewin
      First page: 1461
      Abstract: Circadian rhythms in metabolism, hormone secretion, cell cycle and locomotor activity are regulated by a molecular circadian clock with the master clock in the suprachiasmatic nucleus of the central nervous system. However, an internal clock is also expressed in several peripheral tissues. Although about 10% of all genes are regulated by clock machinery an internal molecular circadian clock in the parathyroid glands has not previously been investigated. Parathyroid hormone secretion exhibits a diurnal variation and parathyroid hormone gene promoter contains an E-box like element, a known target of circadian clock proteins.
      Citation: Kidney International (2020)
      PubDate: 2020-07-25
      DOI: 10.1016/j.kint.2020.06.034
       
  • Results of an explorative clinical evaluation suggest immediate and
           persistent post-reperfusion metabolic paralysis drives kidney ischemia
           reperfusion injury.
    • Authors: Jan H. Lindeman; Leonie G. Wijermars, Sarantos Kostidis, Oleg A. Mayboroda, Amy C. Harms, Thomas Hankemeier, Jörgen Bierau, Karthick B. Sai Sankar Gupta, Martin Giera, Marlies E. Reinders, Melissa C. Zuiderwijk Bsc, Sylvia E. Le Dévédec, Alexander F. Schaapherder, Jaap A. Bakker
      First page: 1476
      Abstract: Delayed graft function is the manifestation of ischemia reperfusion injury in the context of kidney transplantation. While hundreds of interventions successfully reduce ischemia reperfusion injury in experimental models, all clinical interventions have failed. This explorative clinical evaluation examined possible metabolic origins of clinical ischemia reperfusion injury combining data from 18 pre- and post-reperfusion tissue biopsies with 36 sequential arteriovenous blood samplings over the graft in three study groups.
      Citation: Kidney International (2020)
      PubDate: 2020-08-08
      DOI: 10.1016/j.kint.2020.07.026
       
  • Kidney-intrinsic factors determine the severity of ischemia/reperfusion
           injury in a mouse model of delayed graft function
    • Authors: Longhui Qiu; Xingqiang Lai, Jiao-jing Wang, Xin Yi Yeap, Shulin Han, Feibo Zheng, Charlie Lin, Zhuoli Zhang, Daniele Procissi, Deyu Fang, Lin Li, Edward B. Thorp, Michael M. Abecassis, Yashpal S. Kanwar, Zheng J. Zhang
      First page: 1489
      Abstract: Delayed graft function due to transplant ischemia/reperfusion injury adversely affects up to 50% of deceased-donor kidney transplant recipients. However, key factors contributing to the severity of ischemia/reperfusion injury remain unclear. Here, using a clinically relevant mouse model of delayed graft function, we demonstrated that donor genetic background and kidney-intrinsic MyD88/Trif-dependent innate immunity were key determinants of delayed graft function. Functional deterioration of kidney grafts directly corresponded with the duration of cold ischemia time.
      Citation: Kidney International (2020)
      PubDate: 2020-08-18
      DOI: 10.1016/j.kint.2020.07.033
       
  • SARS-CoV-2 receptor networks in diabetic and COVID-19 associated kidney
           disease
    • Authors: Rajasree Menon; Edgar A. Otto, Rachel Sealfon, Viji Nair, Aaron K. Wong, Chandra L. Theesfeld, Xi Chen, Yuan Wang, Avinash S. Boppana, Jinghui Luo, Yingbao Yang, Peter M. Kasson, Jennifer A. Schaub, Celine C. Berthier, Sean Eddy, Chrysta C. Lienczewski, Bradley Godfrey, Susan L. Dagenais, Ryann Sohaney, John Hartman, Damian Fermin, Lalita Subramanian, Helen C. Looker, Jennifer L. Harder, Laura H. Mariani, Jeffrey B. Hodgin, Jonathan Z. Sexton, Christiane E. Wobus, Abhijit S. Naik, Robert G. Nelson, Olga G. Troyanskaya, Matthias Kretzler
      First page: 1502
      Abstract: COVID-19 morbidity and mortality are increased in patients with diabetes and kidney disease via unknown mechanisms. SARS-CoV-2 uses angiotensin-converting enzyme 2 (ACE2) for entry into host cells. Since ACE2 is a susceptibility factor for infection, we investigated how diabetic kidney disease and medications alter ACE2 receptor expression in kidneys. Single cellRNA profiling of healthy living donor and kidney biopsies from patients with diabetic kidney disease revealed ACE2 expression primarily in proximal tubular epithelial cells.
      Citation: Kidney International (2020)
      PubDate: 2020-10-07
      DOI: 10.1016/j.kint.2020.09.015
       
  • Low incidence of SARS-CoV-2, risk factors of mortality and the course of
           illness in the French national cohort of dialysis patients.
    • Authors: Couchoud Cécile; Bayer Florian, Ayav Carole, Béchade Clémence, Brunet Philippe, Chantrel François, Frimat Luc, Galland Roula, Hourmant Maryvonne, Laurain Emmanuelle, Lobbedez Thierry, Mercadal Lucile, Moranne Olivier, in the name of the French REIN registry
      First page: 1519
      Abstract: The aim of this study was to estimate the incidence of COVID-19 disease in the French national population of dialysis patients, their course of illness and to identify the risk factors associated with mortality. Our study included all patients on dialysis recorded in the French REIN Registry in April 2020. Clinical characteristics at last follow-up and the evolution of COVID-19 illness severity over time were recorded for diagnosed cases (either suspicious clinical symptoms, characteristic signs on the chest scan or a positive reverse transcription polymerase chain reaction) for SARS-CoV-2.
      Citation: Kidney International (2020)
      PubDate: 2020-08-24
      DOI: 10.1016/j.kint.2020.07.042
       
  • Outcomes of patients with end-stage kidney disease hospitalized with
           COVID-19
    • Authors: Jia H. Ng; Jamie S. Hirsch, Rimda Wanchoo, Mala Sachdeva, Vipulbhai Sakhiya, Susana Hong, Kenar D. Jhaveri, Steven Fishbane, Northwell COVID-19 Research Consortium the Northwell Nephrology COVID-19 Research Consortium
      First page: 1530
      Abstract: Given the high risk of infection-related mortality, patients with end-stage kidney disease (ESKD) may be at increased risk with COVID-19. To assess this, we compared outcomes of patients with and without ESKD, hospitalized with COVID-19. This was a retrospective study of patients admitted with COVID-19 from 13 New York. hospitals from March 1, 2020, to April 27, 2020, and followed through May 27, 2020. We measured primary outcome (in-hospital death), and secondary outcomes (mechanical ventilation and length of stay), Of 10,482 patients with COVID-19, 419 had ESKD.
      Citation: Kidney International (2020)
      PubDate: 2020-08-15
      DOI: 10.1016/j.kint.2020.07.030
       
  • Results from the ERA-EDTA Registry indicate a high mortality due to
           COVID-19 in dialysis patients and kidney transplant recipients across
           Europe.
    • Authors: Kitty J. Jager; Anneke Kramer, Nicholas C. Chesnaye, Cécile Couchoud, J. Emilio Sánchez-Álvarez, Liliana Garneata, Fréderic Collart, Marc H. Hemmelder, Patrice Ambühl, Julia Kerschbaum, Camille Legeai, María Dolores del Pino y Pino, Gabriel Mircescu, Lionel Mazzoleni, Tiny Hoekstra, Rebecca Winzeler, Gert Mayer, Vianda S. Stel, Christoph Wanner, Carmine Zoccali, Ziad A. Massy
      First page: 1540
      Abstract: The aim of this study was to investigate 28-day mortality after COVID-19 diagnosis in the European kidney replacement therapy population. In addition, we determined the role of patient characteristics, treatment factors, and country on mortality risk using ERA-EDTA Registry data on patients receiving kidney replacement therapy in Europe between February 1, 2020 and April 30, 2020. Additional data on all patients with a diagnosis of COVID-19 were collected from seven European countries encompassing 4298 patients.
      Citation: Kidney International (2020)
      PubDate: 2020-09-22
      DOI: 10.1016/j.kint.2020.09.006
       
  • An initial report from the French SOT COVID Registry suggests high
           mortality due to Covid-19 in recipients of kidney transplants.
    • Authors: Sophie Caillard; Dany Anglicheau, Marie Matignon, Antoine Durrbach, Clarisse Greze, Luc Frimat, Olivier Thaunat, Tristan Legris, Valerie Moal, Pierre Francois Westeel, Nassim Kamar, Philippe Gatault, Renaud Snanoudj, Antoine Sicard, Dominique Bertrand, Charlotte Colosio, Lionel Couzi, Jonathan M. Chemouny, Christophe Masset, Gilles Blancho, Jamal Bamoulid, Agnes Duveau, Nicolas Bouvier, Nathalie Chavarot, Philippe Grimbert, Bruno Moulin, Yannick Le Meur, Marc Hazzan, French SOT COVID Registry
      First page: 1549
      Abstract: Notwithstanding the ongoing coronavirus disease-2019 (Covid-19) pandemic, information on its clinical presentation and prognosis in recipients of a kidney transplant remain scanty. The aim of this registry-based observational study was to explore characteristics and clinical outcomes of recipients of kidney transplants included in the French nationwide Registry of Solid Organ Transplant Recipients with Covid-19. Covid-19 was diagnosed in symptomatic patients who had a positive PCR assay for SARS-CoV-2 or having typical lung lesions on imaging.
      Citation: Kidney International (2020)
      PubDate: 2020-08-23
      DOI: 10.1016/j.kint.2020.08.005
       
  • COVID-19 infection in kidney transplant recipients at the epicenter of
           pandemics
    • Authors: Yorg Azzi; Michael Parides, Omar Alani, Pablo Loarte-Campos, Rachel Bartash, Stefanie Forest, Adriana Colovai, Maria Ajaimy, Luz Liriano-Ward, Cindy Pynadath, Jay Graham, Marie Le, Stuart Greenstein, Juan Rocca, Milan Kinkhabwala, Enver Akalin
      First page: 1559
      Abstract: We investigated the prevalence and clinical outcomes of COVID-19 in recipients of kidney transplants in the Bronx, New York, one of the epicenters of the pandemic. Between March 16 and June 2, 2020, 132 kidney transplant recipients tested positive by SARS-CoV-2 RT-PCR. From May 3 to July 29, 2020, 912 kidney transplant recipients were screened for SARS-CoV-2 IgG antibodies during routine clinic visits, of which 16.6% tested positive. Fifty-five of the 152 patients had previously tested positive by RT-PCR, while the remaining 97 did not have significant symptoms and had not been previously tested by RT-PCR.
      Citation: Kidney International (2020)
      PubDate: 2020-10-15
       
  • IMPact of the COVID-19 epidemic on the moRTAlity of kidney transplant
           recipients and candidates in a French Nationwide registry sTudy
           (IMPORTANT).
    • Authors: Olivier Thaunat; Camille Legeai, Dany Anglicheau, Lionel Couzi, Gilles Blancho, Marc Hazzan, Myriam Pastural, Emilie Savoye, Florian Bayer, Emmanuel Morelon, Yann Le Meur, Olivier Bastien, Sophie Caillard, French nationwide Registry of Solid Organ Transplant Recipients with COVID-19
      First page: 1568
      Abstract: End stage kidney disease increase the risk of COVID-19 related death but how the kidney replacement strategy should be adapted during the pandemic is unknown. Chronic hemodialysis makes social distancing difficult to achieve. Alternatively, kidney transplantation could increase the severity of COVID-19 due to therapeutic immunosuppression and contribute to saturation of intensive care units. For these reasons, kidney transplantation was suspended in France during the first epidemic wave. Here, we retrospectively evaluated this strategy by comparing the overall and COVID-19 related mortality in kidney transplant recipients and candidates over the last three years.
      Citation: Kidney International (2020)
      PubDate: 2020-10-29
       
  • Evaluating multiple living kidney donor candidates simultaneously is more
           cost-effective than sequentially.
    • Authors: Steven Habbous; Lianne Barnieh, Scott Klarenbach, Braden Manns, Sisira Sarma, Mehmet A. Begen, Kenneth Litchfield, Krista L. Lentine, Sunita Singh, Amit X. Garg
      First page: 1578
      Abstract: When multiple living donor candidates come forward to donate a kidney to the same recipient, some living donor programs evaluate one candidate at a time to avoid unnecessary evaluations. Evaluating multiple candidates concurrently rather than sequentially may be cost-effective from a societal perspective if it reduces the time recipients spend on dialysis. We used a simple decision tree to estimate the cost-effectiveness of evaluating two to four candidates simultaneously rather than sequentially as potential kidney donors for the same intended recipient.
      Citation: Kidney International (2020)
      PubDate: 2020-06-30
      DOI: 10.1016/j.kint.2020.06.015
       
  • An International Cohort Study of Autosomal Dominant Tubulointerstitial
           
    • Authors: Martina Živná; Kendrah Kidd, Mohamad Zaidan, Petr Vyleťal, Veronika Barešová, Kateřina Hodaňová, Jana Sovová, Hana Hartmannová, Miroslav Votruba, Helena Trešlová, Ivana Jedličková, Jakub Sikora, Helena Hůlková, Victoria Robins, Aleš Hnízda, Jan Živný, Gregory Papagregoriou, Laurent Mesnard, Bodo B. Beck, Andrea Wenzel, Kálmán Tory, Karsten Häeffner, Matthias T.F. Wolf, Michael E. Bleyer, John A. Sayer, Albert C.M. Ong, Lídia Balogh, Anna Jakubowska, Agnieszka Łaszkiewicz, Rhian Clissold, Charles Shaw-Smith, Raj Munshi, Robert M. Haws, Claudia Izzi, Irene Capelli, Marisa Santostefano, Claudio Graziano, Francesco Scolari, Amy Sussman, Howard Trachtman, Stephane Decramer, Marie Matignon, Philippe Grimbert, Lawrence R. Shoemaker, Christoforos Stavrou, Mayssa Abdelwahed, Neila Belghith, Matthew Sinclair, Kathleen Claes, Tal Kopel, Sharon Moe, Constantinos Deltas, Bertrand Knebelmann, Luca Rampoldi, Stanislav Kmoch, Anthony J. Bleyer
      First page: 1589
      Abstract: There have been few clinical or scientific reports of autosomal dominant tubulointerstitial kidney disease due to REN mutations (ADTKD-REN), limiting characterization. To further study this, we formed an international cohort characterizing 111 individuals from 30 families with both clinical and laboratory findings. Sixty-nine individuals had a REN mutation in the signal peptide region (signal group), 27 in the prosegment (prosegment group), and 15 in the mature renin peptide (mature group). Signal group patients were most severely affected, presenting at a mean age of 19.7 years, with the prosegment group presenting at 22.4 years, and the mature group at 37 years.
      Citation: Kidney International (2020)
      PubDate: 2020-07-31
      DOI: 10.1016/j.kint.2020.06.041
       
  • Genotype-phenotype correlations influence the response to
           angiotensin-targeting drugs in Japanese patients with male X-linked Alport
           syndrome.
    • Authors: Tomohiko Yamamura; Tomoko Horinouchi, China Nagano, Takashi Omori, Nana Sakakibara, Yuya Aoto, Shinya Ishiko, Koichi Nakanishi, Yuko Shima, Hiroaki Nagase, Hiroki Takeda, Rini Rossanti, Ming Juan Ye, Yoshimi Nozu, Shingo Ishimori, Takeshi Ninchoji, Hiroshi Kaito, Naoya Morisada, Kazumoto Iijima, Kandai Nozu
      First page: 1605
      Abstract: Early kidney failure in the hereditary type IV collagen disease, Alport syndrome, can be delayed by renin-angiotensin inhibitors. However, whether all patients and all different genotypes respond equally well to this kidney-protective therapy remains unclear. Here, we performed a retrospective study on 430 patients with male X-linked Alport syndrome to examine the relationships among kidney prognosis, genotype, and treatment effect in a large cohort of Japanese patients. We analyzed the clinical features, genotype-phenotype correlation, and kidney survival period for patients treated with or without renin-angiotensin inhibitors.
      Citation: Kidney International (2020)
      PubDate: 2020-07-23
      DOI: 10.1016/j.kint.2020.06.038
       
  • Successful Simultaneous Pancreas and Kidney Transplant in a Patient
           Post-COVID-19 Infection
    • Authors: Neeraj Singh; Srijan Tandukar, Gazi Zibari, Muhammad Saad Naseer, Hosein S. Amiri, Millie Samaniego
      First page: 1615
      Abstract: The Coronavirus Disease-2019 (COVID-19) pandemic has slowed down the solid organ transplantation worldwide. Although, we have heard of few solid organ transplants having been performed in patients recovered from COVID-19 infection, none has been reported yet. We present a patient who underwent a simultaneous pancreas and kidney transplantation (SPK) after recovering from COVID-19 and is doing well close to 2 months post-transplantation. A 66-year-old Caucasian female with end-stage renal disease (ESRD) secondary to insulin dependent type 2 diabetes mellitus was called in to undergo SPK.
      Citation: Kidney International (2020)
      PubDate: 2020-09-15
      DOI: 10.1016/j.kint.2020.09.004
       
  • Significant impact of COVID-19 on organ donation and transplantation in a
           low-prevalence country: Australia.
    • Authors: S.J. Chadban; M. McDonald, K. Wyburn, H. Opdam, L. Barry, P.T. Coates
      First page: 1616
      Abstract: The incidence and impact of COVID-19 has varied enormously across the globe. The pandemic has negatively impacted organ donation and transplantation in countries that have experienced high rates of infection, including the USA, France and the UK, all reporting greater than 50% reductions in transplant activity1,2. Australia has experienced a significantly lower incidence of COVID-19 (Table 1). Despite this, the impact on organ transplantation has been significant.
      Citation: Kidney International (2020)
      PubDate: 2020-10-20
       
  • Response to “Registry reports in COVID-19 patients: juggling with big
           data, poor data, and no data”
    • Authors: Marc Hazzan; Sophie Caillard
      First page: 1618
      Abstract: We thank Søfteland and coworkers (1) for their interest in our registry based-study focusing on COVID-19 in kidney transplant recipients (2). First, the authors lament that a discrepancy exists in the number of patients reported in the “Introduction” section (n=426) and those included in the final analysis (n=279). However, the 147 excluded patients had
      Citation: Kidney International (2020)
      PubDate: 2020-10-13
      DOI: 10.1016/j.kint.2020.09.018
       
  • Registry reports in COVID-19 patients: juggling with big data, poor data,
           and no data
    • Authors: John Søfteland; Kristian Karason, Jesper Magnusson, Andreas Schult, Marie Felldin, Vanda Friman, Mihai Oltean
      First page: 1618
      Abstract: We read with great interest the paper by Caillard et al. recently accepted in the Journal (1), which is an interesting addition to the burgeoning COVID-19 literature (2). However, we noted a discrepancy between the 426 kidney transplant patients reported to the registry and the 279 cases presented, which corresponds to a third of all patients. These available but unreported cases may have significantly impacted the results, but the authors neither explain this omission nor acknowledge it as a limitation.
      Citation: Kidney International (2020)
      PubDate: 2020-10-13
      DOI: 10.1016/j.kint.2020.09.017
       
  • Thrombotic microangiopathy: COVID-19 or Hydroxychloroquine'
    • Authors: Nuri Baris Hasbal
      First page: 1619
      Abstract: To the Editor, I read with great interest the Letter to the Editor by Jhaveri et al. reporting the first published case report of thrombotic microangiopathy in a patient with COVID-19.1 While there was a clear temporal relationship between the presentation with COVID-19 and development of thrombotic microangiopathy, I wonder whether the authors considered the possibility of a drug-induced thrombotic microangiopathy in particular hydroxychloroquine which was introduced on Day 1 of admission.
      Citation: Kidney International (2020)
      PubDate: 2020-09-21
      DOI: 10.1016/j.kint.2020.08.030
       
  • Response to Thrombotic Microangiopathy: COVID-19 or
           Hydroxychloroquine'
    • Authors: Rimda Wanchoo; Maria Louise Barilla-LaBarca, Kenar D. Jhaveri
      First page: 1620
      Abstract: We thank Dr Hasbal for the concern expressed (1) regarding hydroxychloroquine (HCQ) as the cause of the TMA in our published case titled “Thrombotic microangiopathy (TMA) in a patient with COVID-19”(2). An immune mediated thrombotic microangiopathy usually requires ongoing exposure to the drug. In our case, the patient mentioned was on HCQ for a duration of 5 days. The initial 2 doses were prior to the admission and the drug was continued during the initial 3 days of hospitalization. The findings of hemolysis and TMA developed on day 17 of the admission which was 2 weeks after the drug had been discontinued.
      Citation: Kidney International (2020)
      PubDate: 2020-09-21
      DOI: 10.1016/j.kint.2020.09.009
       
 
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