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    - UROLOGY, NEPHROLOGY AND ANDROLOGY (156 journals)

UROLOGY, NEPHROLOGY AND ANDROLOGY (156 journals)                     

Showing 1 - 157 of 157 Journals sorted alphabetically
Acta Urológica Portuguesa     Open Access   (Followers: 1)
Actas Urológicas Españolas     Full-text available via subscription   (Followers: 3)
Actas Urológicas Españolas (English Edition)     Full-text available via subscription   (Followers: 1)
Advances in Chronic Kidney Disease     Full-text available via subscription   (Followers: 11)
Advances in Urology     Open Access   (Followers: 13)
African Journal of Nephrology     Open Access  
African Journal of Urology     Open Access   (Followers: 7)
AJP Renal Physiology     Hybrid Journal   (Followers: 8)
Aktuelle Urologie     Hybrid Journal   (Followers: 4)
American Journal of Kidney Diseases     Hybrid Journal   (Followers: 43)
American Journal of Men's Health     Open Access   (Followers: 9)
American Journal of Nephrology     Full-text available via subscription   (Followers: 38)
Andrologia     Hybrid Journal   (Followers: 2)
Andrology     Hybrid Journal   (Followers: 4)
Andrology & Gynecology : Current Research     Hybrid Journal   (Followers: 4)
Andrology and Genital Surgery     Open Access   (Followers: 7)
Andrology-Open Access     Open Access  
Annales d'Urologie     Full-text available via subscription  
Arab Journal of Nephrology and Transplantation     Open Access   (Followers: 1)
Arab Journal of Urology     Open Access   (Followers: 7)
Archives of Clinical Nephrology     Open Access   (Followers: 2)
Archivio Italiano di Urologia e Andrologia     Open Access   (Followers: 1)
Archivos Españoles de Urología     Open Access  
Asian Journal of Andrology     Open Access   (Followers: 1)
Asian Journal of Urology     Open Access   (Followers: 3)
Bangladesh Journal of Urology     Open Access   (Followers: 5)
BANTAO Journal     Open Access  
Basic and Clinical Andrology     Open Access  
BJU International     Hybrid Journal   (Followers: 34)
BJUI Compass     Open Access  
BMC Nephrology     Open Access   (Followers: 10)
BMC Urology     Open Access   (Followers: 14)
Canadian Journal of Kidney Health and Disease     Open Access   (Followers: 8)
Canadian Urological Association Journal     Open Access   (Followers: 2)
Cancer Urology     Open Access   (Followers: 2)
Cardiorenal Medicine     Full-text available via subscription   (Followers: 1)
Case Reports in Nephrology     Open Access   (Followers: 5)
Case Reports in Nephrology and Dialysis     Open Access   (Followers: 9)
Case Reports in Urology     Open Access   (Followers: 12)
Clinical and Experimental Nephrology     Hybrid Journal   (Followers: 4)
Clinical Journal of the American Society of Nephrology     Full-text available via subscription   (Followers: 21)
Clinical Kidney Journal     Open Access   (Followers: 4)
Clinical Medicine Insights : Urology     Open Access   (Followers: 3)
Clinical Nephrology     Full-text available via subscription   (Followers: 8)
Clinical Nephrology and Urology Science     Open Access   (Followers: 6)
Clinical Queries: Nephrology     Hybrid Journal   (Followers: 1)
Cuadernos de Cirugía     Open Access   (Followers: 3)
Current Opinion in Nephrology & Hypertension     Hybrid Journal   (Followers: 10)
Current Opinion in Urology     Hybrid Journal   (Followers: 12)
Current Urology     Open Access   (Followers: 10)
Current Urology Reports     Hybrid Journal   (Followers: 5)
Der Nephrologe     Hybrid Journal  
Der Urologe     Hybrid Journal   (Followers: 1)
EMC - Urología     Full-text available via subscription  
Enfermería Nefrológica     Open Access   (Followers: 1)
European Urology     Full-text available via subscription   (Followers: 34)
European Urology Focus     Hybrid Journal   (Followers: 4)
European Urology Supplements     Full-text available via subscription   (Followers: 10)
Forum Nefrologiczne     Full-text available via subscription  
Geriatric Nephrology and Urology     Hybrid Journal   (Followers: 7)
Giornale di Clinica Nefrologica e Dialisi     Open Access  
Herald Urology     Open Access   (Followers: 2)
Hong Kong Journal of Nephrology     Open Access   (Followers: 3)
Human Andrology     Partially Free   (Followers: 2)
IJU Case Reports     Open Access  
Indian Journal of Nephrology     Open Access   (Followers: 2)
Indian Journal of Urology     Open Access   (Followers: 5)
International Brazilian Journal of Urology     Open Access   (Followers: 5)
International Journal of Nephrology     Open Access   (Followers: 2)
International Journal of Nephrology and Renovascular Disease     Open Access   (Followers: 2)
International Journal of Urology     Hybrid Journal   (Followers: 12)
International Urology and Nephrology     Hybrid Journal   (Followers: 7)
Jornal Brasileiro de Nefrologia     Open Access  
Journal für Urologie und Urogynäkologie/Österreich     Hybrid Journal  
Journal of Clinical Nephrology     Open Access   (Followers: 1)
Journal of Clinical Urology     Hybrid Journal   (Followers: 14)
Journal of Endoluminal Endourology     Open Access  
Journal of Endourology     Hybrid Journal   (Followers: 2)
Journal of Endourology Case Reports     Hybrid Journal  
Journal of Genital System & Disorders     Hybrid Journal   (Followers: 3)
Journal of Integrative Nephrology and Andrology     Open Access   (Followers: 2)
Journal of Kidney Cancer and VHL     Open Access  
Journal of Lower Genital Tract Disease     Hybrid Journal  
Journal of Nephrology     Hybrid Journal   (Followers: 4)
Journal of Nephrology Research     Open Access   (Followers: 3)
Journal of Pediatric Nephrology     Open Access   (Followers: 5)
Journal of Renal Care     Hybrid Journal   (Followers: 8)
Journal of Renal Nursing     Full-text available via subscription   (Followers: 12)
Journal of Renal Nutrition     Hybrid Journal   (Followers: 28)
Journal of Renal Nutrition and Metabolism     Open Access   (Followers: 1)
Journal of the American Society of Nephrology     Full-text available via subscription   (Followers: 30)
Journal of The Egyptian Society of Nephrology and Transplantation     Open Access  
Journal of Translational Neurosciences     Open Access  
Journal of Urology     Full-text available via subscription   (Followers: 45)
Journal of Urology & Nephrology     Open Access   (Followers: 2)
Kidney Disease and Transplantation     Open Access   (Followers: 4)
Kidney Diseases     Open Access   (Followers: 3)
Kidney International     Hybrid Journal   (Followers: 47)
Kidney International Reports     Open Access   (Followers: 3)
Kidney Medicine     Open Access  
Kidney Research Journal     Open Access   (Followers: 6)
Kidneys (Počki)     Open Access   (Followers: 1)
Nature Reviews Nephrology     Full-text available via subscription   (Followers: 22)
Nature Reviews Urology     Full-text available via subscription   (Followers: 13)
Nefrología (English Edition)     Open Access  
Nefrología (Madrid)     Open Access  
Nephro-Urology Monthly     Open Access   (Followers: 1)
Nephrology     Hybrid Journal   (Followers: 13)
Nephrology Dialysis Transplantation     Hybrid Journal   (Followers: 27)
Nephron     Hybrid Journal   (Followers: 4)
Nephron Clinical Practice     Full-text available via subscription   (Followers: 4)
Nephron Experimental Nephrology     Full-text available via subscription   (Followers: 4)
Nephron Extra     Open Access   (Followers: 1)
Nephron Physiology     Full-text available via subscription   (Followers: 4)
Neurourology and Urodynamics     Hybrid Journal   (Followers: 1)
OA Nephrology     Open Access   (Followers: 2)
Open Access Journal of Urology     Open Access   (Followers: 6)
Open Journal of Nephrology     Open Access   (Followers: 5)
Open Journal of Urology     Open Access   (Followers: 6)
Open Urology & Nephrology Journal     Open Access  
Pediatric Urology Case Reports     Open Access   (Followers: 7)
Portuguese Journal of Nephrology & Hypertension     Open Access   (Followers: 1)
Progrès en Urologie     Full-text available via subscription  
Progrès en Urologie - FMC     Full-text available via subscription  
Prostate Cancer and Prostatic Diseases     Hybrid Journal   (Followers: 6)
Renal Failure     Open Access   (Followers: 12)
Renal Replacement Therapy     Open Access   (Followers: 4)
Research and Reports in Urology     Open Access   (Followers: 4)
Revista de Nefrología, Diálisis y Trasplante     Open Access   (Followers: 1)
Revista Mexicana de Urología     Open Access   (Followers: 1)
Revista Urologia Colombiana     Open Access  
Saudi Journal of Kidney Diseases and Transplantation     Open Access   (Followers: 2)
Scandinavian Journal of Urology     Hybrid Journal   (Followers: 7)
Seminars in Nephrology     Hybrid Journal   (Followers: 11)
The Prostate     Hybrid Journal   (Followers: 8)
Therapeutic Advances in Urology     Open Access   (Followers: 4)
Trends in Urology & Men's Health     Partially Free   (Followers: 1)
Ukrainian Journal of Nephrology and Dialysis     Open Access   (Followers: 1)
Uro-News     Hybrid Journal   (Followers: 1)
Urolithiasis     Hybrid Journal   (Followers: 2)
Urologia Internationalis     Full-text available via subscription   (Followers: 2)
Urologia Journal     Hybrid Journal  
Urologic Clinics of North America     Full-text available via subscription   (Followers: 4)
Urologic Nursing     Full-text available via subscription   (Followers: 4)
Urologic Radiology     Hybrid Journal  
Urological Science     Open Access  
Urologicheskie Vedomosti     Open Access  
Urologie in der Praxis     Hybrid Journal  
Urologie Scan     Hybrid Journal  
Urology     Hybrid Journal   (Followers: 33)
Urology Annals     Open Access   (Followers: 4)
Urology Case Reports     Open Access   (Followers: 3)
Urology Practice     Full-text available via subscription   (Followers: 2)
Urology Times     Free   (Followers: 3)
Urology Video Journal     Open Access   (Followers: 1)
World Journal of Nephrology and Urology     Open Access   (Followers: 15)
World Journal of Urology     Hybrid Journal   (Followers: 11)

           

Similar Journals
Journal Cover
Kidney International
Journal Prestige (SJR): 3.238
Citation Impact (citeScore): 5
Number of Followers: 47  
 
  Hybrid Journal Hybrid journal (It can contain Open Access articles)
ISSN (Print) 0085-2538 - ISSN (Online) 1523-1755
Published by NPG Homepage  [137 journals]
  • Title Page
    • Citation: Kidney International 99, 3 (2021)
      PubDate: 2021-03
      DOI: 10.1016/S0085-2538(21)00150-2
      Issue No: Vol. 99, No. 3 (2021)
       
  • Subscription Information
    • Citation: Kidney International 99, 3 (2021)
      PubDate: 2021-03
      DOI: 10.1016/S0085-2538(21)00149-6
      Issue No: Vol. 99, No. 3 (2021)
       
  • KDIGO 2021 Clinical Practice Guideline for the Management of Blood
           Pressure in Chronic Kidney Disease
    • Authors: Kidney Disease: Improving Global Outcomes (KDIGO) Blood Pressure Work Group
      Abstract: The development and publication of this guideline were supported by KDIGO. The opinions or views expressed in this professional education supplement are those of the authors and do not necessarily reflect the opinions or recommendations of the International Society of Nephrology or Elsevier. Dosages, indications, and methods of use for products that are referred to in the supplement by the authors may reflect their clinical experience or may be derived from the professional literature or other clinical sources.
      Citation: Kidney International 99, 3 (2021)
      PubDate: 2021-03
      DOI: 10.1016/j.kint.2020.11.003
      Issue No: Vol. 99, No. 3 (2021)
       
  • Hyperphosphatemia in chronic kidney disease exacerbates atherosclerosis
           via a mannosidases-mediated complex-type conversion of SCAP N-glycans
    • Authors: Chao Zhou; Quan He, Hua Gan, Tingting Zeng, Qiao Liu, John F. Moorhead, Zac Varghese, Nan Ouyang, Xiong Z. Ruan
      Abstract: Blood phosphate levels are linked to atherosclerotic cardiovascular disease in patients with chronic kidney disease (CKD), but the molecular mechanisms remain unclear. Emerging studies indicate an involvement of hyperphosphatemia in CKD accelerated atherogenesis through disturbed cholesterol homeostasis. Here, we investigated a potential atherogenic role of high phosphate concentrations acting through aberrant activation of sterol regulatory element-binding protein (SREBP) and cleavage-activating protein (SCAP)-SREBP2 signaling in patients with CKD, hyperphosphatemic apolipoprotein E (ApoE) knockout mice, and cultured vascular smooth muscle cells.
      Citation: Kidney International (2021)
      PubDate: 2021-02-22
      DOI: 10.1016/j.kint.2021.01.016
       
  • Proteinuria converts hepatic heparan sulfate to an effective proprotein
           convertase subtilisin kexin type 9 enzyme binding partner
    • Authors: Pragyi Shrestha; Saleh Yazdani, Romain R. Vivès, Rana El Masri, Wendy Dam, Bart van de Sluis, Jacob van den Born
      Abstract: Hepatic uptake of triglyceride-rich remnant lipoproteins is mediated by the low-density lipoprotein receptor, a low-density lipoprotein receptor related protein and the heparan sulfate proteoglycan, syndecan-1. Heparan sulfate proteoglycan also mediates low-density lipoprotein receptor degradation by a regulator of cholesterol homeostasis, proprotein convertase subtilisin kexin type 9 (PCSK9), thereby hampering triglyceride-rich remnant lipoproteins uptake. In this study, we investigated the effects of proteinuria on PCSK9, hepatic heparan sulfate proteoglycan and plasma triglyceride-rich remnant lipoproteins.
      Citation: Kidney International (2021)
      PubDate: 2021-02-17
      DOI: 10.1016/j.kint.2021.01.023
       
  • Making human collecting ducts and modelling disease in the laboratory
    • Authors: Adrian S. Woolf
      Abstract: Human pluripotent stem cells (hPSCs) are derived from early embryos (embryonic SCs) or made by regressing mature tissues (induced PSCs). Theoretically, such cells have the potential to form all tissue types. Reasons to generate kidney tissues from hPSCs include: understanding normal kidney development; modeling kidney disorders; and making kidney cells for regenerative medicine therapies.1
      Citation: Kidney International (2021)
      PubDate: 2021-02-16
      DOI: 10.1016/j.kint.2021.02.012
       
  • A multicenter blinded preclinical randomized controlled trial on Jak1/2
           inhibition in MRL/MpJ-Faslpr mice with proliferative lupus nephritis
           predicts low effect size.
    • Authors: Yutian Lei; Bettina Sehnert, Reinhard E. Voll, Conxita Jacobs-Cachá, Maria Jose Soler, Maria D. Sanchez-Niño, Alberto Ortiz, Roman D. Bülow, Peter Boor, Hans-Joachim Anders
      Abstract: Data reproducibility and single-center bias are concerns in preclinical research and compromise translation from animal to human. Multicenter preclinical randomized controlled trials (pRCT) may reduce the gap between experimental studies and RCT and improve the predictability of results, for example Jak1/2 inhibition in lupus nephritis. To evaluate this, we conducted the first pRCT in the kidney domain at two Spanish and two German academic sites. Eligible MRL/MpJ-Faslpr mice (female, age13-14 weeks, stress scores of less than two and no visible tumor or signs of infection) were equally randomized to either oral treatment with the Jak1/2 inhibitor baricitinib or vehicle for four weeks.
      Citation: Kidney International (2021)
      PubDate: 2021-02-16
      DOI: 10.1016/j.kint.2021.01.024
       
  • The time of onset of intradialytic hypotension during a hemodialysis
           session associates with clinical parameters and mortality.
    • Authors: David F. Keane; Jochen G. Raimann, Hanjie Zhang, Joanna Willetts, M.S. Stephan Thijssen, Peter Kotanko
      Abstract: Intradialytic hypotension (IDH) is a common complication of hemodialysis, but there is no data about the time of onset during treatment. Here we describe the incidence of IDH throughout hemodialysis and associations of time of hypotension with clinical parameters and survival by analyzing data from 21 dialysis clinics in the United States to include 785682 treatments from 4348 patients. IDH was defined as a systolic blood pressure of 90 mmHg or under while IDH incidence was calculated in 30-minute intervals throughout the hemodialysis session.
      Citation: Kidney International (2021)
      PubDate: 2021-02-16
      DOI: 10.1016/j.kint.2021.01.018
       
  • The urgent need to vaccinate dialysis patients against SARS-CoV-2: A call
           to action
    • Authors: Anna Francis; Colin Baigent, T. Alp Ikizler, Paul Cockwell, Vivekanand Jha
      Abstract: The COVID-19 pandemic is causing extreme stress to many health systems and an ever-mounting death toll. Out of the darkness of the last 14 months comes a beacon of hope in the form of multiple SARS-Cov-2 vaccines. To best utilize this precious resource, we must efficiently deploy vaccination to high-risk groups.
      Citation: Kidney International (2021)
      PubDate: 2021-02-11
      DOI: 10.1016/j.kint.2021.02.003
       
  • Glomerular filtrate affects the dynamics of podocyte detachment in a model
           of diffuse toxic podocytopathy
    • Authors: Nobuyuki Saga; Kazuo Sakamoto, Taiji Matsusaka, Michio Nagata
      Abstract: Podocyte injury and subsequent detachment are hallmarks of progressive glomerulosclerosis. In addition to cell injury, unknown mechanical forces on the injured podocyte may promote detachment. To identify the nature of these mechanical forces, we studied the dynamics of podocyte detachment using sequential ultrastructural geometry analysis by transmission electron microscopy in NEP25, a mouse model of podocytopathy induced by anti-Tac(Fv)-PE38 (LMB2), a fusion protein attached to Pseudomonas exotoxin A, targeting CD25 on podocytes.
      Citation: Kidney International (2021)
      PubDate: 2021-02-11
      DOI: 10.1016/j.kint.2020.12.034
       
  • AI Applications in Renal Pathology
    • Authors: Yuankai Huo; Ruining Deng, Quan Liu, Agnes B. Fogo, Haichun Yang
      Abstract: The explosive growth of artificial intelligence (AI) technologies, especially deep learning methods, has been translated at revolutionary speed to efforts in AI-assisted healthcare. New applications of AI to renal pathology have recently become available, driven by the successful AI deployments in digital pathology. However, synergetic developments of renal pathology and AI require close interdisciplinary collaborations between computer scientists and renal pathologists. Computer scientists should understand that not every AI innovation is translatable to renal pathology, while renal pathologists should capture high-level principles of the relevant AI technologies.
      Citation: Kidney International (2021)
      PubDate: 2021-02-10
      DOI: 10.1016/j.kint.2021.01.015
       
  • GBM nephritis - Crescentic renal inflammation and immunosuppressive
           intervention in the time of the SARS-CoV-2 pandemic
    • Authors: Silke R. Brix; Rachel B. Jones, David R.W. Jayne
      Abstract: the diagnosis and management of autoimmune disorders is challenging in the current pandemic of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we describe the case of a patient with anti-glomerular-basement-membrane (GBM) disease complicated by a SARS-CoV-2 infection to highlight the importance of appropriate immunosuppression and individualized care in respect of these two disease processes.
      Citation: Kidney International (2021)
      PubDate: 2021-02-10
      DOI: 10.1016/j.kint.2021.02.004
       
  • Whole exome sequencing of large populations: identification of loss of
           function alleles and implications for inherited kidney diseases
    • Authors: Robert Geraghty; Eric Olinger, John A. Sayer
      Abstract: Technological advances in next-generation DNA sequencing now allow fast and cost-effective sequencing of the ‘exome’, defined as all the exons in the genome. Such is the rapidity and accessibility of this technique that whole exome sequencing (WES) is becoming a first-line diagnostic tool for the investigation of many diseases, including cancers, metabolic disorders, and childhood neurodevelopmental disorders.
      Citation: Kidney International (2021)
      PubDate: 2021-02-04
      DOI: 10.1016/j.kint.2020.12.036
       
  • Uromodulin fights UTI with sugars
    • Authors: Andrew Beenken; Qais Al-Awqati
      Abstract: Modification of host receptor proteins with sugars, or glycosylation, is essential for the binding of many pathogens. For instance, Group B streptococcus, Helicobacter pylori, and uropathogenic Type 1 fimbriated Escherichia coli (UPEC), among others, all bind to sugars present on the membrane proteins of epithelial cells. In a recent study published in Science, Weiss et al. have shown that a specific glycosylation on uromodulin is required for it to bind UPEC and prevent colonization of bladder epithelia.
      Citation: Kidney International (2021)
      PubDate: 2021-02-04
      DOI: 10.1016/j.kint.2020.12.035
       
  • High rates of long-term renal recovery in survivors of COVID-19-associated
           acute kidney injury requiring kidney replacement therapy
    • Authors: H. Stockmann; J.-H.B. Hardenberg, A. Aigner, C. Hinze, I. Gotthardt, B. Stier, K.-U. Eckardt, K.M. Schmidt-Ott, P. Enghard
      Abstract: While acute kidney injury requiring kidney replacement therapy (AKI-KRT) is an important and severe complication in COVID-19 patients, data on its long-term outcomes are currently limited. Previous studies reported that 65-70% of patients with AKI-KRT had recovered from dialysis dependency at the time of hospital discharge.1,2 However, long-term renal outcomes are unknown, since post-hospital follow-up after COVID-19-associated AKI in previous studies was limited to short observational periods.1,3 We retrospectively analyzed renal outcomes in 74 hospitalized COVID-19 patients with AKI-KRT in a large tertiary care center in Berlin, Germany, between March and June 2020.
      Citation: Kidney International (2021)
      PubDate: 2021-01-26
      DOI: 10.1016/j.kint.2021.01.005
       
  • Best Practices for Correctly Identifying Coronavirus by Transmission
           Electron Microscopy
    • Authors: Hannah A. Bullock; Cynthia S. Goldsmith, Sara E. Miller
      Abstract: To summarize, intracellular coronaviruses are 60 to 140-nm round-to-ovoid particles, with dark 6 to 12-nm dots inside and will be contained inside a vacuole; spikes (if visible) will touch the vacuolar contents, not the cell cytosol, and will not be as prominent as those on clathrin-coated vesicles. Extracellular virus particles, released through the plasma membrane by exocytosis, will cling to the cell surface, and may be more likely to show surface projections, and the spikes will face the extracellular space. Thus, the ultrastructural findings in tissue described in many of the published articles does not confirm the presence of coronavirus directly in tissue, and, when in doubt, investigators should consult an ultrastructural virologist or one of the virology authors listed.6,29-37,39-45,47-49
      Citation: Kidney International (2021)
      PubDate: 2021-01-21
      DOI: 10.1016/j.kint.2021.01.004
       
  • Two episodes of SARS-CoV-2 infection in a patient on chronic hemodialysis.
           A note of caution.
    • Authors: M. Torreggiani; B. Ebikili, S. Blanchi, G.B. Piccoli
      Abstract: Knowledge about COVID-19 patterns in frail patients is still incomplete. Patients on chronic haemodialysis have a high risk both of infection and of severe disease because of their fragility and unavoidable health-care related contacts.
      Citation: Kidney International (2021)
      PubDate: 2021-01-20
      DOI: 10.1016/j.kint.2021.01.003
       
  • Non-oxidized parathyroid hormone (PTH) measured by current method is not
           superior to total PTH in assessing bone turnover in chronic kidney
           disease.
    • Authors: Stan R. Ursem; Annemieke C. Heijboer, Patrick C. D’Haese, Geert J. Behets, Etienne Cavalier, Marc G. Vervloet, Pieter Evenepoel
      Abstract: Parathyroid hormone (PTH) is a key regulator of bone turnover but can be oxidized in vivo, which impairs biological activity. Variable PTH oxidation may account for the rather poor correlation of PTH with indices of bone turnover in chronic kidney disease. Here, we tested whether non-oxidized PTH is superior to total PTH as a marker of bone turnover in 31 patients with kidney failure included from an ongoing prospective observational bone biopsy study and selected to cover the whole spectrum of bone turnover.
      Citation: Kidney International (2021)
      PubDate: 2021-01-07
      DOI: 10.1016/j.kint.2020.12.024
       
  • Differential expression of microRNA miR-150-5p in IgA nephropathy as a
           potential mediator and marker of disease progression.
    • Authors: Izabella ZA. Pawluczyk; Athanasios Didangelos, Sean J. Barbour, Lee Er, Jan U. Becker, Roberto Martin, Scott Taylor, Jasraj S. Bhachu, Edward G. Lyons, Robert Jenkins, Donald Fraser, Karen Molyneux, Javier Perales-Patón, Julio Saez-Rodriguez, Jonathan Barratt
      Abstract: Understanding why certain patients with IgA nephropathy progress to kidney failure while others maintain normal kidney function remains a major unanswered question. To help answer this, we performed miRnome profiling by next generation sequencing of kidney biopsies in order to identify microRNAs specifically associated with the risk of IgA nephropathy progression. Following sequencing and validation in independent cohorts, four microRNAs (-150-5p, -155-5p, -146b-5p, -135a-5p) were found to be differentially expressed in IgA nephropathy progressors compared to non-progressors, and patients with thin membrane nephropathy, lupus nephritis and membranous nephropathy, and correlated with estimated glomerular filtration rate, proteinuria, and the Oxford MEST-C scores (five histological features that are independent predictors of clinical outcome).
      Citation: Kidney International (2021)
      PubDate: 2021-01-05
      DOI: 10.1016/j.kint.2020.12.028
       
  • Chlorthalidone with potassium citrate decreases calcium oxalate stones and
           increases bone quality in genetic hypercalciuric stone-forming rats.
    • Authors: Nancy S. Krieger; John Asplin, Ignacio Granja, Luojing Chen, Daiana Spataru, Tong Tong Wu, Marc Grynpas, David A. Bushinsky
      Abstract: To study human idiopathic hypercalciuria we developed an animal model, genetic hypercalciuric stone-forming rats, whose pathophysiology parallels that of human idiopathic hypercalciuria. Fed the oxalate precursor, hydroxyproline, every rat in this model develops calcium oxalate stones. Using this rat model, we tested whether chlorthalidone and potassium citrate combined would reduce calcium oxalate stone formation and improve bone quality more than either agent alone. These rats (113 generation) were fed a normal calcium and phosphorus diet with hydroxyproline and divided into four groups: diets plus potassium chloride as control, potassium citrate, chlorthalidone plus potassium chloride, or potassium citrate plus chlorthalidone.
      Citation: Kidney International (2021)
      PubDate: 2021-01-05
      DOI: 10.1016/j.kint.2020.12.023
       
  • Rho-GTPase Activating Protein myosin MYO9A identified as a novel candidate
           gene for monogenic focal segmental glomerulosclerosis.
    • Authors: Qi Li; Ashima Gulati, Mathieu Lemaire, Timothy Nottoli, Allen Bale, Alda Tufro
      Abstract: Focal segmental glomerulosclerosis (FSGS) is a podocytopathy leading to kidney failure, whose molecular cause frequently remains unresolved. Here, we describe a rare MYO9A loss of function nonsense heterozygous mutation (p.Arg701*) as a possible contributor to disease in a sibling pair with familial FSGS/proteinuria. MYO9A variants of uncertain significance were identified by whole exome sequencing in a cohort of 94 biopsy proven patients with FSGS. MYO9A is an unconventional myosin with a Rho-GAP domain that controls epithelial cell junction assembly, crosslinks and bundles actin and deactivates the small GTPase protein encoded by the RHOA gene.
      Citation: Kidney International (2021)
      PubDate: 2021-01-04
      DOI: 10.1016/j.kint.2020.12.022
       
  • Innate lymphoid cells in kidney diseases
    • Authors: Ruifeng Wang; Yiping Wang, David C.H. Harris, Qi Cao
      Abstract: It is well known that innate immune cells, including dendritic cells, macrophages and natural killer cells contribute to pathogenesis and protection in various kidney diseases. The understanding of innate immunity has been advanced recently by the discovery of a new group of innate lymphoid cells (ILCs) including ILC1, ILC2, and ILC3. ILCs lack adaptive antigen receptors, yet can be triggered by various pathogens and rapidly provide an abundant source of immunomodulatory cytokines to exert immediate immune reactions and direct subsequent innate and adaptive immune responses.
      Citation: Kidney International (2020)
      PubDate: 2020-12-29
      DOI: 10.1016/j.kint.2020.11.023
       
  • A multi-center study on safety and efficacy of immune checkpoint
           inhibitors in cancer patients with kidney transplant.
    • Authors: Naoka Murakami; Patrick Mulvaney, Melissa Danesh, Ala Abudayyeh, Adi Diab, Noha Abdel-Wahab, Maen Abdelrahim, Pascale Khairallah, Shayan Shirazian, Aleksandra Kukla, Itunu O. Owoyemi, Tarek Alhamad, Samir Husami, Madhav Menon, Andrew Santeusanio, Christopher Blosser, Sandra Carias Zuniga, Maria Jose Soler, Francesc Moreso, Zain Mithani, David Ortiz-Melo, Edgar A. Jaimes, Victoria Gutgarts, Erik Lum, Gabriel M. Danovitch, Francesca Cardarelli, Reed E. Drews, Claude Bassil, Jennifer L. Swank, Scott Westphal, Roslyn B. Mannon, Keisuke Shirai, Abhijat Kitchlu, Song Ong, Shana M. Machado, Suraj S. Mothi, Patrick A. Ott, Osama Rahma, F. Stephen Hodi, Meghan E. Sise, Shruti Gupta, David E. Leaf, Craig E. Devoe, Rimda Wanchoo, Vinay V. Nair, Chrysalyne D. Schmults, Glenn J. Hanna, Ben Sprangers, Leonardo V. Riella, Kenar D. Jhaveri, Immune Checkpoint Inhibitors in Solid Organ Transplant Consortium
      Abstract: Immune checkpoint inhibitors (ICIs) are widely used for various malignancies. However, their safety and efficacy in patients with a kidney transplant have not been defined. To delineate this, we conducted a multicenter retrospective study of 69 patients with a kidney transplant receiving ICIs between January 2010 and May 2020. For safety, we assessed the incidence, timing, and risk factors of acute graft rejection. For efficacy, objective response rate and overall survival were assessed in cutaneous squamous cell carcinoma and melanoma, the most common cancers in our cohort, and compared with stage-matched 23 patients with squamous cell carcinoma and 14 with melanoma with a kidney transplant not receiving ICIs.
      Citation: Kidney International (2020)
      PubDate: 2020-12-23
      DOI: 10.1016/j.kint.2020.12.015
       
  • Upregulation of HLA-F expression by BK polyomavirus infection induces
           immune recognition by KIR3DS1-positive natural killer cells.
    • Authors: Tobias F. Koyro; Emma Kraus, Sebastian Lunemann, Angelique Hölzemer, Sonia Wulf, Johannes Jung, Pia Fittje, Florian Henseling, Christian Körner, Tobias B. Huber, Adam Grundhoff, Thorsten Wiech, Ulf Panzer, Nicole Fischer, Marcus Altfeld
      Abstract: BK polyomavirus-associated nephropathy is a common complication after kidney transplantation leading to reduced graft function or loss. The molecular pathogenesis of BK polyomavirus-induced nephropathy is not well understood. A recent study had described a protective effect of the activating natural killer cell receptor KIR3DS1 in BK polyomavirus-associated nephropathy, suggesting a role of NK cells in modulating disease progression. Using an in vitro cell culture model of human BK polyomavirus infection and kidney biopsy samples from patients with BK polyomavirus-associated nephropathy, we observed significantly increased surface expression of the ligand for KIR3DS1, HLA-F, on BK polyomavirus-infected kidney tubular cells.
      Citation: Kidney International (2020)
      PubDate: 2020-12-22
      DOI: 10.1016/j.kint.2020.12.014
       
  • Empagliflozin restores chronic kidney disease-induced impairment of
           endothelial regulation of cardiomyocyte relaxation and contraction
    • Authors: Rio P. Juni; Rushd Al-Shama, Diederik W.D. Kuster, Jolanda van der Velden, Henrike M. Hamer, Marc G. Vervloet, Etto C. Eringa, Pieter Koolwijk, Victor W.M. van Hinsbergh
      Abstract: Chronic kidney disease (CKD) promotes development of cardiac abnormalities and is highly prevalent in patients with heart failure, particularly in those with preserved ejection fraction. CKD is associated with endothelial dysfunction, however, whether CKD can induce impairment of endothelium-to-cardiomyocyte crosstalk leading to impairment of cardiomyocyte function is not known. The sodium-glucose co-transporter 2 inhibitor, empagliflozin, reduced cardiovascular events in diabetic patients with or without CKD, suggesting its potential as a new treatment for heart failure with preserved ejection fraction.
      Citation: Kidney International (2020)
      PubDate: 2020-12-22
      DOI: 10.1016/j.kint.2020.12.013
       
  • Low expression of HIV genes in podocytes accelerates the progression of
           diabetic kidney disease in mice.
    • Authors: Jie Feng; Bao Li, Xuan Wang, Huilin Li, Yuqiang Chen, Wenzhen Xiao, Zhengzhe Li, Liyi Xie, Wanhong Lu, Hongli Jiang, Kyung Lee, John Cijiang He
      Abstract: With the widespread use combination antiretroviral therapy, there has been a dramatic decrease in HIV-associated nephropathy. However, although the patients living with HIV have low or undetectable viral load, the prevalence of chronic kidney disease (CKD) in this population remains high. Additionally, improved survival is associated with aging-related comorbidities such as diabetes and cardiovascular disease. A faster progression of CKD is associated with concurrent HIV infection and diabetes than with HIV infection or diabetes alone.
      Citation: Kidney International (2020)
      PubDate: 2020-12-22
      DOI: 10.1016/j.kint.2020.12.012
       
  • A case-control study indicates that coagulation imbalance is associated
           with arteriosclerosis and markers of endothelial dysfunction in kidney
           failure
    • Authors: Lucie Tran; Bruno Pannier, Patrick Lacolley, Tomas Serrato, Athanase Benetos, Gérard M. London, Yvonnick Bézie, Véronique Regnault
      Abstract: Endothelial dysfunction, one of many causes of arterial changes in end-stage kidney disease (kidney failure). is a likely link between early vascular aging and the risk of thrombosis or bleeding in this condition To evaluate this, we compared links between arterial stiffness and endothelial/coagulation factors in 55 patients receiving hemodialysis therapy and 57 age-/sex-matched control individuals. Arterial stiffness was assessed from carotid-femoral pulse wave velocity, and coagulation status from the endogenous thrombin generating potential.
      Citation: Kidney International (2020)
      PubDate: 2020-12-22
      DOI: 10.1016/j.kint.2020.12.011
       
  • Supplemented ERA-EDTA Registry data evaluated the frequency of dialysis,
           kidney transplantation and comprehensive conservative management for
           patients with kidney failure in Europe.
    • Authors: Vianda S. Stel; Rianne W. de Jong, Anneke Kramer, Anton M. Andrusev, José M. Baltar, Myftar Barbullushi, Samira Bell, Pablo Castro de la Nuez, Harijs Cernevskis, Cécile Couchoud, Johan De Meester, Bjørn O. Eriksen, Lilliana Garneata, Eliezer Golan, Jaakko Helve, Marc H. Hemmelder, Kristine Hommel, Kyriakos Ioannou, Faiçal Jarraya, Nino Kantaria, Julia Kerschbaum, Kirill S. Komissarov, Ángela Magaz, Lucile Mercadal, Mai Ots-Rosenberg, Runolfur Palsson, Axel Rahmel, Helena Rydell, Manuela Savino, Nurhan Seyahi, Maria F. Slon Roblero, Olivera Stojceva-Taneva, Arjan Van der Tol, Evgueniy S. Vazelov, Edita Ziginskiene, Oscar Zurriaga, Raymond C. Vanholder, Ziad A. Massy, Kitty J. Jager
      Abstract: The aims of this study were to determine the frequency of dialysis and kidney transplantation and to estimate the regularity of comprehensive conservative management (CCM) for patients with kidney failure in Europe. This study uses data from the ERA-EDTA Registry. Additionally, our study included supplemental data from Armenia, Germany, Hungary, Ireland, Kosovo, Luxembourg, Malta, Moldova, Montenegro, Slovenia and additional data from Israel, Italy, Slovakia using other information sources. Through an online survey, responding nephrologists estimated the frequency of CCM (i.e.
      Citation: Kidney International (2020)
      PubDate: 2020-12-21
      DOI: 10.1016/j.kint.2020.12.010
       
  • Going Rogue: how autoantibodies become pathogenic
    • Authors: Griffith B. Perkins; Juewan Kim, P. Toby Coates
      Abstract: Refers to: Singh M, Jackson KJL, Wang, JJ, et al. Lymphoma Driver Mutations in the Pathogenic Evolution of an Iconic Human Autoantibody. Cell. 2020;180:1-17
      Citation: Kidney International (2020)
      PubDate: 2020-12-17
       
  • Development and external validation combining existing models and recent
           data into an up-to-date prediction model for evaluating kidneys from older
           deceased donors for transplantation.
    • Authors: Chava L. Ramspek; Mostafa El Moumni, Eelaha Wali, Martin B.A. Heemskerk, Robert A. Pol, Meindert J. Crop, Nichon E. Jansen, Andries Hoitsma, Friedo W. Dekker, M. van Diepen, Cyril Moers
      Abstract: With a rising demand for kidney transplantation, reliable pre-transplant assessment of organ quality becomes top priority. In clinical practice, physicians are regularly in doubt whether suboptimal kidney offers from older donors should be accepted. Here, we externally validate existing prediction models in a European population of older deceased donors, and subsequently developed and externally validated an adverse outcome prediction tool. Recipients of kidney grafts from deceased donors 50 years of age and older were included from the Netherlands Organ Transplant Registry (NOTR) and United States organ transplant registry from 2006-2018.
      Citation: Kidney International (2020)
      PubDate: 2020-12-16
      DOI: 10.1016/j.kint.2020.11.016
       
  • A well-developed endolysosomal system reflects protein reabsorption in
           segment 1 and 2 of rat proximal tubules
    • Authors: Erik I. Christensen; Inger B. Kristoffersen, Birgitte Grann, Jesper S. Thomsen, Arne Andreasen, Rikke Nielsen
      Abstract: Proteinuria is a well-established marker and predictor of kidney disease. The receptors megalin and cubilin reabsorb filtered proteins and thereby proteinuria is avoided. It is unknown if all segments of the proximal tubule are involved in clearing the filtrate or if there exists a reserve capacity in case of increased glomerular protein filtration. To determine this, we performed serial sectioning of rat kidney and used stereology to quantify the endolysosomal system of the three segments of cortical and juxtamedullary nephrons by electron microscopy.
      Citation: Kidney International (2020)
      PubDate: 2020-12-16
      DOI: 10.1016/j.kint.2020.11.015
       
  • Knockout of aminopeptidase A in mice causes functional alterations and
           morphological glomerular basement membrane changes in the kidneys.
    • Authors: Benedikt Marahrens; Arndt Schulze, Jan Wysocki, Meei-Hua Lin, Minghao Ye, Yashpal S. Kanwar, Michael Bader, Juan Carlos Q. Velez, Jeffrey H. Miner, Daniel Batlle
      Abstract: Aminopeptidase A is one of the most potent enzymes within the renin-angiotensin system in terms of angiotensin II degradation. Here, we examined whether there is a kidney phenotype and any compensatory changes in other renin angiotensin system enzymes involved in the metabolism of angiotensin II associated with aminopeptidase A deficiency. Kidneys harvested from aminopeptidase A knockout mice were examined by light and electron microscopy, immunohistochemistry and immunofluorescence. Kidney angiotensin II levels and the ability of renin angiotensin system enzymes in the glomerulus to degrade angiotensin II ex vivo, their activities, protein and mRNA levels in kidney lysates were evaluated.
      Citation: Kidney International (2020)
      PubDate: 2020-12-11
      DOI: 10.1016/j.kint.2020.11.012
       
  • Insights from CREDENCE trial indicate an acute drop in estimated
           glomerular filtration rate during treatment with canagliflozin with
           implications for clinical practice.
    • Authors: Megumi Oshima; Meg J. Jardine, Rajiv Agarwal, George Bakris, Christopher P. Cannon, David M. Charytan, Dick de Zeeuw, Robert Edwards, Tom Greene, Adeera Levin, Soo Kun Lim, Kenneth W. Mahaffey, Bruce Neal, Carol Pollock, Norman Rosenthal, David C. Wheeler, Hong Zhang, Bernard Zinman, Vlado Perkovic, Hiddo J.L. Heerspink
      Abstract: Canagliflozin slows the progression of chronic kidney disease in patients with type 2 diabetes and induces a reversible acute drop in estimated glomerular filtration rate (eGFR), believed to be a hemodynamic effect. Predictors of the initial drop and its association with long-term eGFR trajectories and safety outcomes are unknown. To assess this, we performed a post-hoc analysis of 4289 participants in the CREDENCE trial with type 2 diabetes and chronic kidney disease equally split into treatment and placebo groups who had eGFR measured at both baseline and week three.
      Citation: Kidney International (2020)
      PubDate: 2020-12-11
       
  • Tubular mitochondrial AKT1 is activated during ischemia reperfusion injury
           and has a critical role in predisposition to chronic kidney disease.
    • Authors: Hugo Y-H Lin; Yumay Chen, Yu-Han Chen, Albert P. Ta, Hsiao-Chen Lee, Grant R. MacGregor, Nosratola D. Vaziri, Ping H. Wang
      Abstract: Kidney tubular dysfunction contributes to acute kidney injury and to the transition to chronic kidney disease. Although tubular mitochondria have been implicated in the pathophysiology of kidney failure, the mechanisms are not yet clear. Here, we demonstrated that ischemia-reperfusion injury induced acute translocation and activation of mitochondrial protein kinase B (also known as AKT1) in the kidney tubules. We hypothesized that mitochondrial AKT1 signaling protects against the development of acute kidney injury and subsequent chronic kidney disease.
      Citation: Kidney International (2020)
      PubDate: 2020-12-11
       
  • Mild X-linked Alport syndrome due to the COL4A5 G624D variant originating
           in the Middle Ages is predominant in Central/East Europe and causes kidney
           failure in midlife.
    • Authors: Aleksandra M. Żurowska; Olga Bielska, Patrycja Daca-Roszak, Maciej Jankowski, Maria Szczepańska, Danuta Roszkowska-Bjanid, Elżbieta Kuźma-Mroczkowska, Małgorzata Pańczyk-Tomaszewska, Anna Moczulska, Dorota Drożdż, Despina Hadjipanagi, Constantinos Deltas, Danuta Ostalska-Nowicka, Alina Rabiega, Janina Taraszkiewicz, Katarzyna Taranta-Janusz, Anna Wieczorkiewicz-Plaza, Katarzyna Jobs, Judyta Mews, Kinga Musiał, Anna Jakubowska, Hanna Nosek, Anna E. Jander, Constantina Koutsofti, Anna Stanisławska-Sachadyn, Dominka Kuleszo, Ewa Ziętkiewicz, Beata S. Lipska-Ziętkiewicz
      Abstract: A study of 269 children enrolled into a National Registry for children with persistent glomerular hematuria identified 131 individuals with genetically confirmed X-linked Alport Syndrome. A single variant c.1871G>A p.Gly624Asp (G624D) in COL4A5 was predominant and accounted for 39% of X-linked Alport Syndrome in unrelated Polish families (44 of 113). To evaluate its origins, the genetic variation in a 2.79 Mb segment encompassing the COL4A5 locus on chromosome X was assessed. All G624D alleles were found on the same rare haplotype background, indicating a founder effect dating back to the 12-13th century.
      Citation: Kidney International (2020)
      PubDate: 2020-12-10
       
  • The long-acting C5 inhibitor, ravulizumab, is effective and safe in
           pediatric patients with atypical hemolytic uremic syndrome naïve to
           complement inhibitor treatment
    • Authors: Gema Ariceta; Bradley P. Dixon, Seong Heon Kim, Gaurav Kapur, Teri Mauch, Stephan Ortiz, Marc Vallee, Andrew E. Denker, Hee Gyung Kang, Larry A. Greenbaum
      Abstract: Ravulizumab, a long-acting complement C5 inhibitor engineered from eculizumab, allows extending maintenance dosing from every 2–3 weeks to every 4–8 weeks depending on bodyweight. Here, we evaluated the efficacy and safety of ravulizumab in complement inhibitor-naïve children (under 18 years) with atypical hemolytic uremic syndrome. In this phase III, single-arm trial, ravulizumab was administered every eight weeks in patients 20 kg and over, and four weeks in patients under 20 kg. The primary endpoint was a complete thrombotic microangiopathy response (normalization of platelet count and lactate dehydrogenase, and a 25% or more improvement in serum creatinine) through 26 weeks.
      Citation: Kidney International (2020)
      PubDate: 2020-12-08
       
  • Targeting Energy Pathways in Kidney Disease: The Roles of Sirtuins, AMPK,
           and PGC1α
    • Authors: Amanda J. Clark; Samir M. Parikh
      Abstract: The kidney has extraordinary metabolic demands to sustain the active transport of solutes that is critical to renal filtration and clearance. Mitochondrial health is vital to meet those demands and maintain renal fitness. Decades of studies have linked poor mitochondrial health to kidney disease. Key regulators of mitochondrial health – 5-AMP-activated protein kinase (AMPK), sirtuins, and peroxisome proliferator-activated receptor γ coactivator-1alpha (PGC1α) – have all been shown to play significant roles in renal resilience against disease.
      Citation: Kidney International (2020)
      PubDate: 2020-12-08
      DOI: 10.1016/j.kint.2020.09.037
       
  • Diphenhydramine may be a preventive medicine against cisplatin-induced
           kidney toxicity.
    • Authors: Hirofumi Hamano; Yasumasa Ikeda, Mitsuhiro Goda, Keijo Fukushima, Seiji Kishi, Masayuki Chuma, Michiko Yamashita, Takahiro Niimura, Kenshi Takechi, Masaki Imanishi, Yoshito Zamami, Yuya Horinouchi, Yuki Izawa-Ishizawa, Licht Miyamoto, Keisuke Ishizawa, Hiromichi Fujino, Toshiaki Tamaki, Ken-ichi Aihara, Koichiro Tsuchiya
      Abstract: Cisplatin is widely used as an anti-tumor drug for the treatment of solid tumors. Unfortunately, it causes kidney toxicity as a critical side effect, limiting its use, given that no preventive drug against cisplatin-induced kidney toxicity is currently available. Here, based on a repositioning analysis of the Food and Drug Administration Adverse Events Reporting System, we found that a previously developed drug, diphenhydramine, may provide a novel treatment for cisplatin-induced kidney toxicity.
      Citation: Kidney International (2020)
      PubDate: 2020-12-08
       
  • Age- and sex-dependent clinical equations to estimate glomerular
           filtration rates in children and young adults with chronic kidney disease.
           
    • Authors: Christopher B. Pierce; Alvaro Muñoz, Derek K. Ng, Bradley A. Warady, Susan L. Furth, George J. Schwartz
      Abstract: Using data (2655 observations from 928 participants) from the Chronic Kidney Disease in Children Study, we developed and internally validated new glomerular filtration rate estimating equations for clinical use in children and young adults: two forms of k × [height (ht) serum creatinine (sCr)] and two forms of k × [1 cystatin C(cysC)]. For each marker, one equation used a sex-dependent k; in the other, k is sex-and age-dependent. Glomerular filtration rate (GFR) was measured directly by plasma iohexol disappearance.
      Citation: Kidney International (2020)
      PubDate: 2020-12-07
       
  • A Fast and Simple Clearing and Swelling Protocol for 3D In-Situ Imaging of
           the Kidney across Scales
    • Authors: David Unnersjö-Jess; Linus Butt, Martin Höhne, Anna Witasp, Lucas Kühne, Peter F. Hoyer, Jaakko Patrakka, Paul T. Brinkkötter, Annika Wernerson, Bernhard Schermer, Thomas Benzing, Lena Scott, Hjalmar Brismar, Hans Blom
      Abstract: In recent years, many light-microscopy protocols have been published for visualization of nanoscale structures in the kidney. These protocols present researchers with new tools to evaluate both foot process anatomy and effacement, as well as protein distributions in foot processes, the slit diaphragm and in the glomerular basement membrane. However, these protocols either involve the application of different complicated super resolution microscopes or lengthy sample preparation protocols. Here, we present a fast and simple, five-hour long procedure for three-dimensional visualization of kidney morphology on all length scales.
      Citation: Kidney International (2020)
      PubDate: 2020-12-04
       
  • Translational Science Diet–Microbiota Interaction and Kidney Disease
           Progression
    • Authors: Ziad A. Massy; Tilman B. Drueke
      Abstract: Very high protein intake may lead to increased intraglomerular pressure, glomerular hyperfiltration, and chronic kidney disease (CKD). For this and other reasons dietary protein restriction has long been used with the aim of slowing the progression of CKD. In addition to the quantity of ingested protein, the quality of protein is also of importance for body growth, composition, and function. This also holds true for microbiota growth, composition, and function in the intestine. Generally speaking, nutrient intake is known to modify the relative abundance and the diversity of intestinal microbes, and dietary changes can induce alterations in gut microbial metabolite production.
      Citation: Kidney International (2020)
      PubDate: 2020-11-24
      DOI: 10.1016/j.kint.2020.11.006
       
  • Updating the International IgA Nephropathy Prediction Tool for use in
           children
    • Authors: Sean J. Barbour; Rosanna Coppo, Lee Er, Maria Luisa Russo, Zhi-Hong Liu, Jie Ding, Ritsuko Katafuchi, Norishige Yoshikawa, Hong Xu, Shoji Kagami, Yukio Yuzawa, Francesco Emma, Alexandra Cambier, Licia Peruzzi, Robert J. Wyatt, Daniel C. Cattran, International IgA Nephropathy Network
      Abstract: Although IgA nephropathy (IgAN) is a common cause of glomerulonephritis in children, the absence of a method to predict disease progression limits personalized risk-based treatment decisions. The adult International IgAN Prediction Tool comprises two validated Cox survival models that predict a 50% decline in estimated glomerular filtration rate (eGFR) or end stage kidney disease (ESKD) using clinical risk factors and Oxford MEST histology scores. Here, we updated the Prediction Tool for use in children using a multiethnic international cohort of 1,060 children with IgAN followed into adulthood.
      Citation: Kidney International (2020)
      PubDate: 2020-11-17
       
  • Reduced Lon protease 1 expression in podocytes contributes to the
           pathogenesis of podocytopathy
    • Authors: Wei Gong; Jiayu Song, Jing Liang, Haoyang Ma, Wenxiao Wu, Yue Zhang, Li Yang, Songming Huang, Zhanjun Jia, Aihua Zhang
      Abstract: Emerging evidence has shown that mitochondrial dysfunction is closely related to the pathogenesis of podocytopathy, but the molecular mechanisms mediating mitochondrial dysfunction in podocytes remain unclear. Lon protease 1 is an important soluble protease localized in the mitochondrial matrix, although its exact role in podocyte injury has yet to be determined. Here we investigated the specific role of this protease in podocyte in glomerular injury and the progression of podocytopathy using podocyte-specific Lon protease 1 knockout mice, murine podocytes in culture and kidney biopsy samples from patients with focal segmental glomerular sclerosis and minimal change disease.
      Citation: Kidney International (2020)
      PubDate: 2020-11-09
       
  • The STARMEN trial indicates that alternating treatment with
           corticosteroids and cyclophosphamide is superior to sequential treatment
           with tacrolimus and rituximab in primary membranous nephropathy.
    • Authors: Gema Fernández-Juárez; Jorge Rojas-Rivera, Anne-Els van de Logt, Joana Justino, Angel Sevillano, Fernando Caravaca-Fontán, Ana Ávila, Cristina Rabasco, Virginia Cabello, Alfonso Varela, Montserrat Díez, Guillermo Martín-Reyes, Marian Goicoechea Diezhandino, Luis F. Quintana, Irene Agraz, Juan Ramón Gómez-Martino, Mercedes Cao, Antolina Rodríguez-Moreno, Begoña Rivas, Cristina Galeano, Jose Bonet, Ana Romera, Amir Shabaka, Emmanuelle Plaisier, Mario Espinosa, Jesus Egido, Alfonso Segarra, Gérard Lambeau, Pierre Ronco, Jack Wetzels, Manuel Praga, STARMEN investigators
      Abstract: A cyclical corticosteroid-cyclophosphamide regimen is recommended for patients with primary membranous nephropathy at high risk of progression. We hypothesized that sequential therapy with tacrolimus and rituximab is superior to cyclical alternating treatment with corticosteroids and cyclophosphamide in inducing persistent remission in these patients. This was tested in a randomized, open-label controlled trial of 86 patients with primary membranous nephropathy and persistent nephrotic syndrome after six-months observation and assigned 43 each to receive six-month cyclical treatment with corticosteroid and cyclophosphamide or sequential treatment with tacrolimus (full-dose for six months and tapering for another three months) and rituximab (one gram at month six).
      Citation: Kidney International (2020)
      PubDate: 2020-11-06
       
  • Changes in cancer incidence and outcomes among kidney transplant
           recipients in the United States over a thirty-year period.
    • Authors: Christopher D. Blosser; Gregory Haber, Eric A. Engels
      Abstract: Recipients of kidney transplants have elevated cancer risk compared with the general population. Improvements over time in transplant care and cancer treatment may have affected incidence and outcomes of cancer among recipients of kidney transplant. To evaluate this, we used linked United States transplant and cancer registry data to study 101,014 adult recipients of kidney transplants over three decades (1987-1996, 1997-2006, 2007-2016). Poisson regression was used to assess trends in incidence for cancer overall and seven common cancers.
      Citation: Kidney International (2020)
      PubDate: 2020-11-04
       
  • Estimation of the glomerular filtration rate in children and young adults
           using the CKD-EPI equation with age-adjusted creatinine values.
    • Authors: Jonas Björk; Ulf Nyman, Anders Larsson, Pierre Delanaye, Hans Pottel
      Abstract: The CKD-EPI creatinine-based estimation equation for glomerular filtration rate (GFR) cannot be used in children, overestimates GFR in young adults, and its combination with the KDIGO recommended pediatric CKiD (Schwartz bedside) equation causes implausible increases in estimated GFR when switching from pediatric to adult care. By establishing sex-specific creatinine growth curves for children and young adults, creatinine levels of children and young adults below age 40 years were adjusted with 40 as assigned age and applied in the CKD-EPI equation.
      Citation: Kidney International (2020)
      PubDate: 2020-11-03
       
  • Clinical and immunological follow-up of very long-term kidney transplant
           
    • Authors: Amaury Dujardin; Mélanie Chesneau, Florian Dubois, Richard Danger, Linh Bui, Clarisse Kerleau, Pierrick Guérif, Sophie Brouard, Jacques Dantal
      Abstract: Operationally tolerant kidney transplant recipients harbor an immunological signature, associated with low rejection risk, and focused on B lymphocytes. Here, we investigated whether patients with long-term transplantation and still on immunosuppressive therapy would present such a signature of low immunological rejection risk, compared to more recently transplanted patients. Of 114 kidney transplant recipients enrolled, 38 with more than 25 years of graft survival and stable graft function under calcineurin inhibitors, were matched with two different groups of transplanted patients (10-15 and 5-7 years after transplantation).
      Citation: Kidney International (2020)
      PubDate: 2020-10-30
      DOI: 10.1016/j.kint.2020.09.036
       
  • EOS789, a broad-spectrum inhibitor of phosphate transport, is safe with an
           indication of efficacy in a Phase 1b randomized cross-over trial in
           hemodialysis patients.
    • Authors: Kathleen M. Hill Gallant; Elizabeth R. Stremke, Laurie Trevino, Ranjani N. Moorthi, Simit Doshi, Meryl E. Wastney, Nozomi Hisada, Jotaro Sato, Yoshitaka Ogita, Naohisa Fujii, Yuya Matsuda, Takei Kake, Sharon M. Moe
      Abstract: The treatment of hyperphosphatemia remains challenging in patients receiving hemodialysis. This Phase 1b study assessed safety and efficacy of EOS789, a novel pan-inhibitor of phosphate transport (NaPi-2b, PiT-1, PiT-2) on intestinal phosphate absorption in patients receiving intermittent hemodialysis therapy. Two cross-over, randomized order studies of identical design (ten patients each) compared daily EOS789 50 mg to placebo with meals and daily EOS789 100 mg vs EOS789 100 mg plus 1600 mg sevelamer with meals.
      Citation: Kidney International (2020)
      PubDate: 2020-10-30
      DOI: 10.1016/j.kint.2020.09.035
       
  • Meta-analysis uncovers genome-wide significant variants for rapid kidney
           function decline.
    • Authors: Mathias Gorski; Bettina Jung, Yong Li, Pamela R. Matias-Garcia, Matthias Wuttke, Stefan Coassin, Chris H.L. Thio, Marcus E. Kleber, Thomas W. Winkler, Veronika Wanner, Jin-Fang Chai, Audrey Y. Chu, Massimiliano Cocca, Mary F. Feitosa, Sahar Ghasemi, Anselm Hoppmann, Katrin Horn, Man Li, Teresa Nutile, Markus Scholz, Karsten B. Sieber, Alexander Teumer, Adrienne Tin, Judy Wang, Bamidele O. Tayo, Tarunveer S. Ahluwalia, Peter Almgren, Stephan J.L. Bakker, Bernhard Banas, Nisha Bansal, Mary L. Biggs, Eric Boerwinkle, Erwin P. Bottinger, Hermann Brenner, Robert J. Carroll, John Chalmers, Miao-Li Chee, Miao-Ling Chee, Ching-Yu Cheng, Josef Coresh, Martin H. de Borst, Frauke Degenhardt, Kai-Uwe Eckardt, Karlhans Endlich, Andre Franke, Sandra Freitag-Wolf, Piyush Gampawar, Ron T. Gansevoort, Mohsen Ghanbari, Christian Gieger, Pavel Hamet, Kevin Ho, Edith Hofer, Bernd Holleczek, Valencia Hui Xian Foo, Nina Hutri-Kähönen, Shih-Jen Hwang, M. Arfan Ikram, Navya Shilpa Josyula, Mika Kähönen, Chiea-Chuen Khor, Wolfgang Koenig, Holly Kramer, Bernhard K. Krämer, Brigitte Kühnel, Leslie A. Lange, Terho Lehtimäki, Wolfgang Lieb, Lifelines cohort study, Regeneron Genetics Center, Ruth J.F. Loos, Mary Ann Lukas, Leo-Pekka Lyytikäinen, Christa Meisinger, Thomas Meitinger, Olle Melander, Yuri Milaneschi, Pashupati P. Mishra, Nina Mononen, Josyf C. Mychaleckyj, Girish N. Nadkarni, Matthias Nauck, Kjell Nikus, Boting Ning, Ilja M. Nolte, Michelle L. O’Donoghue, Marju Orho-Melander, Sarah A. Pendergrass, Brenda W.J. H. Penninx, Michael H. Preuss, Bruce M. Psaty, Laura M. Raffield, Olli T. Raitakari, Rainer Rettig, Myriam Rheinberger, Kenneth M. Rice, Alexander R. Rosenkranz, Peter Rossing, Jerome I. Rotter, Charumathi Sabanayagam, Helena Schmidt, Reinhold Schmidt, Ben Schöttker, Christina-Alexandra Schulz, Sanaz Sedaghat, Christian M. Shaffer, Konstantin Strauch, Silke Szymczak, Kent D. Taylor, Johanne Tremblay, Layal Chaker, Pim van der Harst, Peter J. van der Most, Niek Verweij, Uwe Völker, Melanie Waldenberger, Lars Wallentin, Dawn M. Waterworth, Harvey D. White, James G. Wilson, Tien-Yin Wong, Mark Woodward, Qiong Yang, Masayuki Yasuda, Laura M. Yerges-Armstrong, Yan Zhang, Harold Snieder, Christoph Wanner, Carsten A. Böger, Anna Köttgen, Florian Kronenberg, Cristian Pattaro, Iris M. Heid
      Abstract: Rapid decline of glomerular filtration rate estimated from creatinine (eGFRcrea) is associated with severe clinical endpoints. In contrast to cross-sectionally assessed eGFRcrea, the genetic basis for rapid eGFRcrea decline is largely unknown. To help define this, we meta-analyzed 42 genome-wide association studies from the Chronic Kidney Diseases Genetics Consortium and United Kingdom Biobank to identify genetic loci for rapid eGFRcrea decline. Two definitions of eGFRcrea decline were used: 3 mL/min/1.73m2/year or more (“Rapid3”; encompassing 34,874 cases, 107,090 controls) and eGFRcrea decline 25% or more and eGFRcrea under 60 mL/min/1.73m2 at follow-up among those with eGFRcrea 60 mL/min/1.73m2 or more at baseline (“CKDi25”; encompassing 19,901 cases, 175,244 controls).
      Citation: Kidney International (2020)
      PubDate: 2020-10-30
      DOI: 10.1016/j.kint.2020.09.030
       
  • Neural cell adhesion molecule 1 is a novel autoantigen in membranous lupus
           nephritis.
    • Authors: Tiffany Caza; Samar Hassen, Michael Kuperman, Shree Sharma, Zeljko Dvanajscak, John Arthur, Rick Edmondson, Aaron Storey, Christian Herzog, Daniel Kenan, Christopher Larsen
      Abstract: Membranous lupus nephritis is a frequent cause of nephrotic syndrome in patients with systemic lupus erythematosus. It has been shown in phospholipase A2 receptor positive membranous; nephropathy that known antibodies can be detected within sera, determination of the target; autoantigen can have diagnostic significance, inform prognosis, and enable non-invasive; monitoring of disease activity. Here we utilized mass spectrometry for antigen discovery in laser; captured microdissected glomeruli from formalin-fixed paraffin embedded tissue and tissue; protein G immunoprecipitation studies to interrogate immune complexes from frozen kidney; biopsy tissue.
      Citation: Kidney International (2020)
      PubDate: 2020-10-09
      DOI: 10.1016/j.kint.2020.09.016
       
  • Plasma cadmium is associated with increased risk of long-term kidney graft
           failure.
    • Authors: Camilo G. Sotomayor; Dion Groothof, Joppe J. Vodegel, Michele F. Eisenga, Tim J. Knobbe, Jan IJmker, Rosa G.M. Lammerts, Martin H. de Borst, Stefan P. Berger, Ilja M. Nolte, Ramón Rodrigo, Riemer H.J.A. Slart, Gerjan J. Navis, Daan J. Touw, Stephan J.L. Bakker
      Abstract: The kidney is one of the most sensitive organs to cadmium-induced toxicity, particularly in conditions of long-term oxidative stress. We hypothesized that, in kidney transplant recipients, nephrotoxic exposure to cadmium represents an overlooked hazard for optimal graft function. To test this, we performed a prospective cohort study and included 672 outpatient kidney transplant recipients with a functioning graft of beyond one year. The median plasma cadmium was 58 ng/L. During a median 4.9 years of follow-up, 78 kidney transplant recipients developed graft failure with a significantly different distribution across tertiles of plasma cadmium (13, 26, and 39 events, respectively).
      Citation: Kidney International (2020)
      PubDate: 2020-09-13
      DOI: 10.1016/j.kint.2020.08.027
       
  • Mineral bone disease in autosomal dominant polycystic kidney disease.
    • Authors: Berenice Gitomer; Renata Pereira, Isidro B. Salusky, Jason W. Stoneback, Tamara Isakova, Xuan Cai, Lorien S. Dalrymple, Norma Ofsthun, Zhiying You, Harmut H. Malluche, Franklin Maddux, Diana George, Vicente Torres, Arlene Chapman, Theodore I. Steinman, Myles Wolf, Michel Chonchol
      Abstract: Mice with disruption of Pkd1 in osteoblasts demonstrate reduced bone mineral density, trabecular bone volume and cortical thickness. To date, the bone phenotype in adult patients with autosomal dominant polycystic kidney disease (ADPKD) with stage I and II chronic kidney disease has not been investigated. To examine this, we characterized biochemical markers of mineral metabolism, examined bone turnover and biology, and estimated risk of fracture in patients with ADPKD. Markers of mineral metabolism were measured in 944 patients with ADPKD and other causes of kidney disease.
      Citation: Kidney International (2020)
      PubDate: 2020-09-10
      DOI: 10.1016/j.kint.2020.07.041
       
  • Renin-angiotensin aldosterone inhibitor use at hospital discharge among
           patients with moderate to severe acute kidney injury and its association
           with recurrent acute kidney injury and mortality.
    • Authors: Edward D. Siew; Sharidan K. Parr, Khaled Abdel-Kader, Amy M. Perkins, Robert A. Greevy, Andrew J. Vincz, Jason Denton, Otis D. Wilson, Adriana M. Hung, T. Alp Ikizler, Cassianne Robinson-Cohen, Michael E. Matheny
      Abstract: Recurrent episodes of acute kidney injury (AKI) are common among AKI survivors. Renin-angiotensin aldosterone inhibitors (RAASi) are often indicated for these patients but may increase the risk for recurrent AKI. Here, we examined whether RAASi associates with a higher risk for recurrent AKI and mortality among survivors of moderate to severe AKI in a retrospective cohort of Veterans who survived Stage II or III AKI. The primary exposure was RAASi at hospital discharge and the primary endpoint was recurrent AKI within 12 months.
      Citation: Kidney International (2020)
      PubDate: 2020-09-08
      DOI: 10.1016/j.kint.2020.08.022
       
  • Prediction modelling - Part 2 - Using machine learning strategies to
           improve transplantation outcomes
    • Authors: Craig Peter Coorey; Ankit Sharma, Samuel Mueller, Jean Yang
      Abstract: Kidney transplant recipients and transplant physicians face important clinical questions where machine learning methods may help improve the decision-making process. This mini-review explores potential applications of machine learning methods to key stages of a kidney transplant recipient’s journey, from initial waitlisting and donor selection, to personalization of immunosuppression and prediction of post-transplantation events. Both unsupervised and supervised machine learning methods are presented, including k-means clustering, principal components analysis, k-nearest neighbors and random forests.
      Citation: Kidney International (2020)
      PubDate: 2020-09-07
      DOI: 10.1016/j.kint.2020.08.026
       
  • Time-dependent lymphocyte count after transplantation is associated with
           higher risk of graft failure and death.
    • Authors: Amaury Dujardin; Marine Lorent, Yohann Foucher, Christophe Legendre, Clarisse Kerleau, Sophie Brouard, Magali Giral, DIVAT consortium
      Abstract: The transplantation field requires the identification of specific risk factors associated with the level of immunosuppression. Here, our aim was to analyze the association between the number of circulating lymphocytes, monitored routinely by complete blood cell counts during outpatient visits, and patient and graft survival. In total, 2,999 kidney or combined kidney-pancreas recipients transplanted between 2000 and 2016, from two University hospitals, were enrolled. We investigated the etiological relationship between time-dependent lymphocyte count beyond one year after transplantation and patient and graft survival, viral infection and cancer risk using time-dependent multivariate Cox models.
      Citation: Kidney International (2020)
      PubDate: 2020-09-03
      DOI: 10.1016/j.kint.2020.08.010
       
  • Development and testing of an artificial intelligence tool for predicting
           end stage kidney disease in patients with immunoglobulin A nephropathy.
    • Authors: Francesco Paolo Schena; Vito Walter Anelli, Joseph Trotta, Tommaso Di Noia, Carlo Manno, Giovanni Tripepi, Graziella D’Arrigo, Nicholas C. Chesnaye, Maria Luisa Russo, Maria Stangou, Aikaterini Papagianni, Carmine Zoccali, Vladimir Tesar, Rosanna Coppo
      Abstract: We have developed an artificial neural network prediction model for end-stage kidney disease (ESKD) in patients with primary immunoglobulin A nephropathy (IgAN) using a retrospective cohort of 948 patients with IgAN. Our tool is based on a two-step procedure of a classifier model that predicts ESRD, and a regression model that predicts development of ESKD over time. The classifier model showed a performance value of 0.82 (area under the receiver operating characteristic curve) in patients with a follow-up of five years, which improved to 0.89 at the ten-year follow-up.
      Citation: Kidney International (2020)
      PubDate: 2020-09-01
      DOI: 10.1016/j.kint.2020.07.046
       
  • NELL1 is a target antigen in malignancy-associated membranous nephropathy
    • Authors: Tiffany Caza; Samar Hassen, Zeljko Dvanajscak, Michael Kuperman, Rick Edmondson, Christian Herzog, Aaron Storey, John Arthur, L. Nicholas Cossey, Shree Sharma, Daniel Kenan, Christopher Larsen
      Abstract: Patients with membranous nephropathy have an increased risk of malignancy compared to the general population, but the target antigen for malignancy-associated membranous nephropathy is unknown. To explore this, we utilized mass spectrometry for antigen discovery in malignancy-associated membranous nephropathy examining immune complexes eluted from frozen kidney biopsy tissue using protein G bead immunoglobulin capture. Antigen discovery was performed comparing cases of membranous nephropathy of unknown and known type.
      Citation: Kidney International (2020)
      PubDate: 2020-08-19
      DOI: 10.1016/j.kint.2020.07.039
       
  • Simultaneous Glomerular Filtration Rate Determination Using Inulin,
           Iohexol and 99mTc-DTPA Demonstrates the Need for Customized Measurement
           Protocols
    • Authors: Christine A. White; Ayub Akbari, Celine Allen, Andrew G. Day, Patrick A. Norman, David Holland, Michael A. Adams, Greg A. Knoll
      Abstract: Urinary inulin clearance is considered the gold standard of glomerular filtration rate (GFR)measurement but plasma clearance of less expensive and more accessible tracers is more commonly performed. Many plasma sampling protocols exist but little is known about their accuracy. Here, the study objectives were to compare plasma iohexol and 99mTc-DTPA GFR with varying sampling strategies to the GFR measured by urinary inulin and to identify protocols with the greatest accuracy according to clinical characteristics.
      Citation: Kidney International (2020)
      PubDate: 2020-07-31
      DOI: 10.1016/j.kint.2020.06.044
       
 
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