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UROLOGY, NEPHROLOGY AND ANDROLOGY (151 journals)                     

Showing 1 - 151 of 151 Journals sorted alphabetically
Acta Urológica Portuguesa     Open Access   (Followers: 1)
Actas Urológicas Españolas     Full-text available via subscription   (Followers: 3)
Actas Urológicas Españolas (English Edition)     Full-text available via subscription   (Followers: 1)
Advances in Chronic Kidney Disease     Full-text available via subscription   (Followers: 11)
Advances in Urology     Open Access   (Followers: 12)
African Journal of Nephrology     Open Access  
African Journal of Urology     Open Access   (Followers: 6)
AJP Renal Physiology     Hybrid Journal   (Followers: 8)
Aktuelle Urologie     Hybrid Journal   (Followers: 11)
American Journal of Kidney Diseases     Hybrid Journal   (Followers: 37)
American Journal of Men's Health     Open Access   (Followers: 8)
American Journal of Nephrology     Full-text available via subscription   (Followers: 36)
Andrologia     Hybrid Journal   (Followers: 2)
Andrology     Hybrid Journal   (Followers: 2)
Andrology & Gynecology : Current Research     Hybrid Journal   (Followers: 4)
Andrology and Genital Surgery     Open Access   (Followers: 7)
Andrology-Open Access     Open Access  
Annales d'Urologie     Full-text available via subscription  
Arab Journal of Nephrology and Transplantation     Open Access   (Followers: 1)
Arab Journal of Urology     Open Access   (Followers: 6)
Archivio Italiano di Urologia e Andrologia     Open Access   (Followers: 1)
Archivos Españoles de Urología     Open Access  
Asian Journal of Andrology     Open Access   (Followers: 1)
Asian Journal of Urology     Open Access   (Followers: 2)
Bangladesh Journal of Urology     Open Access   (Followers: 4)
BANTAO Journal     Open Access  
Basic and Clinical Andrology     Open Access  
BJU International     Hybrid Journal   (Followers: 37)
BMC Nephrology     Open Access   (Followers: 8)
BMC Urology     Open Access   (Followers: 14)
Canadian Journal of Kidney Health and Disease     Open Access   (Followers: 6)
Canadian Urological Association Journal     Open Access   (Followers: 2)
Cancer Urology     Open Access   (Followers: 1)
Cardiorenal Medicine     Full-text available via subscription   (Followers: 1)
Case Reports in Nephrology     Open Access   (Followers: 5)
Case Reports in Nephrology and Dialysis     Open Access   (Followers: 8)
Case Reports in Urology     Open Access   (Followers: 11)
Clinical and Experimental Nephrology     Hybrid Journal   (Followers: 4)
Clinical Journal of the American Society of Nephrology     Full-text available via subscription   (Followers: 17)
Clinical Medicine Insights : Urology     Open Access   (Followers: 2)
Clinical Nephrology     Full-text available via subscription   (Followers: 8)
Clinical Nephrology and Urology Science     Open Access   (Followers: 5)
Clinical Queries: Nephrology     Hybrid Journal   (Followers: 1)
Current Opinion in Nephrology & Hypertension     Hybrid Journal   (Followers: 10)
Current Opinion in Urology     Hybrid Journal   (Followers: 11)
Current Urology     Open Access   (Followers: 9)
Current Urology Reports     Hybrid Journal   (Followers: 4)
Der Nephrologe     Hybrid Journal  
Der Urologe     Hybrid Journal   (Followers: 8)
EMC - Urología     Full-text available via subscription  
Enfermería Nefrológica     Open Access   (Followers: 1)
European Urology     Full-text available via subscription   (Followers: 38)
European Urology Focus     Hybrid Journal   (Followers: 5)
European Urology Supplements     Full-text available via subscription   (Followers: 14)
Forum Nefrologiczne     Full-text available via subscription  
Geriatric Nephrology and Urology     Hybrid Journal   (Followers: 6)
Giornale di Clinica Nefrologica e Dialisi     Open Access  
Herald Urology     Open Access   (Followers: 1)
Hong Kong Journal of Nephrology     Open Access   (Followers: 3)
Human Andrology     Partially Free   (Followers: 2)
IJU Case Reports     Open Access  
Indian Journal of Nephrology     Open Access   (Followers: 2)
Indian Journal of Urology     Open Access   (Followers: 4)
International Brazilian Journal of Urology     Open Access   (Followers: 4)
International Journal of Nephrology     Open Access   (Followers: 2)
International Journal of Nephrology and Renovascular Disease     Open Access   (Followers: 2)
International Journal of Urology     Hybrid Journal   (Followers: 12)
International Urology and Nephrology     Hybrid Journal   (Followers: 7)
Jornal Brasileiro de Nefrologia     Open Access  
Journal für Urologie und Urogynäkologie/Österreich     Hybrid Journal  
Journal of Clinical Nephrology     Open Access   (Followers: 1)
Journal of Clinical Urology     Hybrid Journal   (Followers: 14)
Journal of Endoluminal Endourology     Open Access  
Journal of Endourology     Hybrid Journal   (Followers: 2)
Journal of Endourology Case Reports     Hybrid Journal  
Journal of Genital System & Disorders     Hybrid Journal   (Followers: 3)
Journal of Integrative Nephrology and Andrology     Open Access   (Followers: 2)
Journal of Kidney Cancer and VHL     Open Access  
Journal of Lower Genital Tract Disease     Hybrid Journal  
Journal of Nephrology     Hybrid Journal   (Followers: 4)
Journal of Nephrology Research     Open Access   (Followers: 3)
Journal of Pediatric Nephrology     Open Access   (Followers: 3)
Journal of Renal Care     Hybrid Journal   (Followers: 8)
Journal of Renal Nursing     Full-text available via subscription   (Followers: 12)
Journal of Renal Nutrition     Hybrid Journal   (Followers: 30)
Journal of Renal Nutrition and Metabolism     Open Access   (Followers: 1)
Journal of the American Society of Nephrology     Full-text available via subscription   (Followers: 25)
Journal of The Egyptian Society of Nephrology and Transplantation     Open Access  
Journal of Translational Neurosciences     Open Access  
Journal of Urology     Full-text available via subscription   (Followers: 55)
Kidney Disease and Transplantation     Open Access   (Followers: 4)
Kidney Diseases     Open Access   (Followers: 3)
Kidney International     Hybrid Journal   (Followers: 42)
Kidney International Reports     Open Access   (Followers: 3)
Kidney Medicine     Open Access  
Kidney Research Journal     Open Access   (Followers: 6)
Nature Reviews Nephrology     Full-text available via subscription   (Followers: 19)
Nature Reviews Urology     Full-text available via subscription   (Followers: 13)
Nefrología (English Edition)     Open Access  
Nefrología (Madrid)     Open Access  
Nephro-Urology Monthly     Open Access   (Followers: 1)
Nephrology     Hybrid Journal   (Followers: 12)
Nephrology Dialysis Transplantation     Hybrid Journal   (Followers: 24)
Nephron     Hybrid Journal   (Followers: 4)
Nephron Clinical Practice     Full-text available via subscription   (Followers: 4)
Nephron Experimental Nephrology     Full-text available via subscription   (Followers: 4)
Nephron Extra     Open Access   (Followers: 1)
Nephron Physiology     Full-text available via subscription   (Followers: 4)
Neurourology and Urodynamics     Hybrid Journal   (Followers: 1)
OA Nephrology     Open Access   (Followers: 2)
Open Access Journal of Urology     Open Access   (Followers: 6)
Open Journal of Nephrology     Open Access   (Followers: 5)
Open Journal of Urology     Open Access   (Followers: 7)
Open Urology & Nephrology Journal     Open Access  
Pediatric Urology Case Reports     Open Access   (Followers: 7)
Portuguese Journal of Nephrology & Hypertension     Open Access   (Followers: 1)
Progrès en Urologie     Full-text available via subscription  
Progrès en Urologie - FMC     Full-text available via subscription  
Prostate Cancer and Prostatic Diseases     Hybrid Journal   (Followers: 6)
Renal Failure     Open Access   (Followers: 11)
Renal Replacement Therapy     Open Access   (Followers: 4)
Research and Reports in Urology     Open Access   (Followers: 4)
Revista de Nefrología, Diálisis y Trasplante     Open Access   (Followers: 1)
Revista Mexicana de Urología     Open Access   (Followers: 1)
Revista Urologia Colombiana     Open Access  
Saudi Journal of Kidney Diseases and Transplantation     Open Access   (Followers: 2)
Scandinavian Journal of Urology     Hybrid Journal   (Followers: 9)
Seminars in Nephrology     Hybrid Journal   (Followers: 11)
The Prostate     Hybrid Journal   (Followers: 8)
Therapeutic Advances in Urology     Open Access   (Followers: 4)
Trends in Urology & Men's Health     Partially Free   (Followers: 1)
Ukrainian Journal of Nephrology and Dialysis     Open Access   (Followers: 1)
Uro-News     Hybrid Journal   (Followers: 2)
Urolithiasis     Hybrid Journal   (Followers: 2)
Urologia Internationalis     Full-text available via subscription   (Followers: 3)
Urologia Journal     Hybrid Journal  
Urologic Clinics of North America     Full-text available via subscription   (Followers: 4)
Urologic Nursing     Full-text available via subscription   (Followers: 3)
Urologic Radiology     Hybrid Journal  
Urological Science     Open Access  
Urologicheskie Vedomosti     Open Access  
Urologie in der Praxis     Hybrid Journal  
Urologie Scan     Hybrid Journal  
Urology     Hybrid Journal   (Followers: 35)
Urology Annals     Open Access   (Followers: 4)
Urology Case Reports     Open Access   (Followers: 3)
Urology Practice     Full-text available via subscription   (Followers: 3)
Urology Times     Free   (Followers: 3)
Urology Video Journal     Open Access  
World Journal of Nephrology and Urology     Open Access   (Followers: 15)
World Journal of Urology     Hybrid Journal   (Followers: 12)


Similar Journals
Journal Cover
Kidney International
Journal Prestige (SJR): 3.238
Citation Impact (citeScore): 5
Number of Followers: 42  
  Hybrid Journal Hybrid journal (It can contain Open Access articles)
ISSN (Print) 0085-2538 - ISSN (Online) 1523-1755
Published by NPG Homepage  [137 journals]
  • Subscription Information
    • Citation: Kidney International 97, 2 (2020)
      PubDate: 2020-02
      DOI: 10.1016/S0085-2538(19)31256-6
      Issue No: Vol. 97, No. 2 (2020)
  • In This Issue
    • First page: 221
      Abstract: Rituximab is used in many glomerular diseases, generally off-label. Most protocols started with the lymphoma dosing schedule of 375 mg/m2, but over the years, an array of schedules have been reported. Chan and colleagues retrospectively analyzed children with frequently relapsing/steroid-dependent nephrotic syndrome to try to determine optimal rituximab management. Rituximab has been used to delay relapse and reduce corticosteroid administration in these children. The investigators noted 3 rituximab dosing courses: low dose—375 mg/m2, medium dose—750 mg/m2, and high dose—1125–1500 mg/m2.
      Citation: Kidney International 97, 2 (2020)
      PubDate: 2020-02
      DOI: 10.1016/j.kint.2019.12.004
      Issue No: Vol. 97, No. 2 (2020)
  • Systemic autoimmune diseases and the kidney
    • Authors: Brad H. Rovin
      Pages: 222 - 225
      Abstract: Since its inception, Kidney International has published seminal articles describing the effects of systemic autoimmune diseases on the kidney. These manuscripts have characterized the pathology and clinical course of these diseases and perhaps most importantly have provided guidance to the nephrology community about how to treat these complex conditions using the best possible evidence available at the time. To illustrate the wealth of information contained within the Kidney International archives, consider the following papers.
      Citation: Kidney International 97, 2 (2020)
      PubDate: 2020-02
      DOI: 10.1016/j.kint.2019.11.002
      Issue No: Vol. 97, No. 2 (2020)
  • Kidney health for everyone everywhere—from prevention to detection and
           equitable access to care
    • Authors: Philip Kam-Tao Li; Guillermo Garcia-Garcia, Siu-Fai Lui, Sharon Andreoli, Winston Wing-Shing Fung, Anne Hradsky, Latha Kumaraswami, Vassilios Liakopoulos, Ziyoda Rakhimova, Gamal Saadi, Luisa Strani, Ifeoma Ulasi, Kamyar Kalantar-Zadeh, World Kidney Day Steering Committee
      Pages: 226 - 232
      Abstract: Around 850 million people currently are affected by different types of kidney disorders.1 Up to 1 in 10 adults worldwide has chronic kidney disease (CKD), which is invariably irreversible and mostly progressive. The global burden of CKD is increasing, and CKD is projected to become the fifth most common cause of years of life lost globally by 2040.2 If CKD remains uncontrolled and if the affected person survives the ravages of cardiovascular and other complications of the disease, CKD progresses to end-stage kidney disease, where life cannot be sustained without dialysis therapy or kidney transplantation.
      Citation: Kidney International 97, 2 (2020)
      PubDate: 2020-02
      DOI: 10.1016/j.kint.2019.12.002
      Issue No: Vol. 97, No. 2 (2020)
  • Statistics and data analyses—a new educational series for
    • Authors: Valeria Saglimbene; Giovanni Strippoli, Jonathan C. Craig, Germaine Wong
      Pages: 233 - 235
      Abstract: Evidence-based medicine has been the backbone of modern health care. Careful evaluation and synthesis of high-quality evidence may provide robust information that can be applied to policy and patient-level decision making, while accounting for patient preferences and needs and local contextual factors, with transformational effects on provision and delivery of care.1 Traditionally, evidence from randomized controlled trials (RCTs) has been considered the pinnacle of the hierarchy of clinical evidence because of the methodological rigor and robustness in RCT design and because RCTs are conducted in controlled settings with minimum risk of bias as a result of selection and confounding issues.
      Citation: Kidney International 97, 2 (2020)
      PubDate: 2020-02
      DOI: 10.1016/j.kint.2019.09.021
      Issue No: Vol. 97, No. 2 (2020)
  • The CKDGen Consortium: ten years of insights into the genetic basis of
           kidney function
    • Authors: Anna Köttgen; Cristian Pattaro
      Pages: 236 - 242
      Abstract: With increasing incidence and a prevalence of >10% among adults worldwide, chronic kidney disease (CKD) represents a major public health issue.1 CKD can lead to metabolic disorders and progress to end-stage kidney disease, and it increases the risk for cardiovascular disease and mortality. Our limited understanding of CKD pathophysiology and the mechanisms influencing kidney function in the healthy range represents a major barrier to the development of treatments targeting the causes rather than the symptoms of CKD.
      Citation: Kidney International 97, 2 (2020)
      PubDate: 2020-02
      Issue No: Vol. 97, No. 2 (2020)
  • Journal Club
    • Pages: 243 - 245
      Abstract: Lees et al. (Glomerular filtration rate by differing measures, albuminuria and prediction of cardiovascular disease, mortality and end-stage kidney disease. Nat Med. 2019;25:1753–1760;
      Citation: Kidney International 97, 2 (2020)
      PubDate: 2020-02
      DOI: 10.1016/j.kint.2019.12.003
      Issue No: Vol. 97, No. 2 (2020)
  • Notch notches lupus
    • Authors: George C. Tsokos
      Pages: 251 - 253
      Abstract: The multifaceted Notch signaling pathway appears to tame the autoimmune response and protect lupus-prone mice from inflammation and damage.
      Citation: Kidney International 97, 2 (2020)
      PubDate: 2020-02
      Issue No: Vol. 97, No. 2 (2020)
  • Potassium channels in control of renal function
    • Authors: Pedro H. Imenez Silva; Carsten A. Wagner
      Pages: 253 - 255
      Abstract: Potassium channels are important to control membrane potential and drive epithelial transport processes. In this issue of Kidney International, Bignon et al. report the role of the Kir4.2 K+-channel, localized at the basolateral membrane of proximal tubules, in the reabsorption of bicarbonate and the modulation of renal ammoniagenesis. The findings have implications for our understanding of how the kidney reacts to hypokalemia, an acid load, and the metabolic acidosis of patients with advanced stages of chronic kidney disease.
      Citation: Kidney International 97, 2 (2020)
      PubDate: 2020-02
      Issue No: Vol. 97, No. 2 (2020)
  • Refining insulin signaling in the proximal tubule at the level of the
    • Authors: Carolyn M. Ecelbarger
      Pages: 256 - 258
      Abstract: Insulin has many varied actions in the proximal tubule. Two distinct activities include upregulation of sodium/bicarbonate reabsorption and downregulation of gluconeogenesis. The inability to perform these 2 tasks simultaneously under fed and fasted conditions can lead to hyper- or hypoglycemia, acidosis, and/or impaired extracellular fluid regulation. Nakamura and colleagues illuminate our understanding of this process, which appears to be managed in part by recruitment of different insulin receptor substrates under different physiological conditions.
      Citation: Kidney International 97, 2 (2020)
      PubDate: 2020-02
      DOI: 10.1016/j.kint.2019.11.018
      Issue No: Vol. 97, No. 2 (2020)
  • Uncovering the etiology of CINAC, a complex and mysterious renal
    • Authors: Mark Haas
      Pages: 258 - 260
      Abstract: Chronic interstitial nephritis in agricultural communities (CINAC) is a progressive form of tubulointerstitial nephritis affecting agricultural workers in different parts of the world. Its underlying etiology is not known, although a study by Vervaet and coworkers in this issue of Kidney International provides strong evidence that CINAC is a lysosomal tubulopathy induced by toxin exposure. Key to this important discovery is a thorough morphologic analysis of kidney tissue, including ultrastructural as well as histopathologic examination.
      Citation: Kidney International 97, 2 (2020)
      PubDate: 2020-02
      Issue No: Vol. 97, No. 2 (2020)
  • Next-generation sequencing for detection of somatic mosaicism in autosomal
           dominant polycystic kidney disease
    • Authors: Olivier Devuyst; York Pei
      Pages: 261 - 263
      Abstract: Mosaicism is defined as the presence of 2 genetically different populations of cells in a single organism, resulting from a mutation during early embryogenesis. Hopp et al. characterized mosaicism in 20 unresolved ADPKD families, using next-generation sequencing techniques with DNA isolated from blood cells. Mosaicism may be involved in 1% of ADPKD families, and it may explain some atypical disease phenotypes.
      Citation: Kidney International 97, 2 (2020)
      PubDate: 2020-02
      DOI: 10.1016/j.kint.2019.11.019
      Issue No: Vol. 97, No. 2 (2020)
  • Considerations for advancing nephrology research and practice through
           natural language processing
    • Authors: Sharidan K. Parr; Glenn T. Gobbel
      Pages: 263 - 265
      Abstract: Much of medical data is buried in the free text of clinical notes and not captured by structured data, such as administrative codes. Natural language processing (NLP) can locate and use information that resides in unstructured free text. Chan et al. demonstrate that NLP is sensitive for identifying symptoms in hemodialysis patients. These findings highlight the benefit NLP may bring to nephrology and should prompt discussion of important considerations for NLP system design and implementation.
      Citation: Kidney International 97, 2 (2020)
      PubDate: 2020-02
      DOI: 10.1016/j.kint.2019.12.001
      Issue No: Vol. 97, No. 2 (2020)
  • The authors reply
    • Authors: Michel Jadoul; Brian A. Bieber, David A. Goodkin, Ronald L. Pisoni
      Pages: 421 - 422
      Abstract: Although our Dialysis Outcomes and Practice Patterns Study reported a relatively slow international decrease of hepatitis C virus (HCV) prevalence and incidence in hemodialysis (HD) units from 1996 to 20121 (before the direct-acting antiviral era), Huang et al. now report their direct-acting antiviral–based elimination of HCV from a single HD unit in Taiwan.2 Such eradication of HCV will reduce the clinical burden associated with HCV infection. In addition, HCV eradication should prevent HCV nosocomial transmission.
      Citation: Kidney International 97, 2 (2020)
      PubDate: 2020-02
      DOI: 10.1016/j.kint.2019.11.005
      Issue No: Vol. 97, No. 2 (2020)
  • Patient-centered outreach treatment toward micro-elimination of hepatitis
           C virus infection in hemodialysis patients
    • Authors: Chung-Feng Huang; Yi-Wen Chiu, Ming-Lung Yu
      First page: 421
      Abstract: We read the report by Jadoul et al.1 with great interest in a recent issue in Kidney International. The World Health Organization has set ambitious goals for hepatitis C virus (HCV) eradication using the “micro-elimination” approach.2 Taiwan has one of the highest prevalence and incidence of end-stage kidney disease worldwide. HCV infection is an important complication among our hemodialysis patients.3 With the advent of the new direct-acting antivirals, complete eradication of HCV infection is one of our key priorities.
      Citation: Kidney International 97, 2 (2020)
      PubDate: 2020-02
      Issue No: Vol. 97, No. 2 (2020)
  • Erratum to “Wu K-Y, Zhang T, Zhao G-X, et al. The C3a/C3aR axis
           mediates anti-inflammatory activity and protects against uropathogenic E
           coli–induced kidney injury in mice.” Kidney Int. 2019;96:612–627
    • First page: 423
      Abstract: In the above-stated article, the publisher regrets that a Western blot was not included in a portion of Figure 4b. The figure in its entirety is below.
      Citation: Kidney International 97, 2 (2020)
      PubDate: 2020-02
      DOI: 10.1016/j.kint.2019.11.014
      Issue No: Vol. 97, No. 2 (2020)
  • Corrigendum to “Sutherland MR, Chatfield MD, Davison B, et al. Renal
           dysfunction is already evident within the first month of life in
           Australian Indigenous infants born preterm.” Kidney Int.
    • First page: 424
      Abstract: The authors of the above-stated article regret that there is a correction to their graphical abstract. The value for urine albumin is 57%.
      Citation: Kidney International 97, 2 (2020)
      PubDate: 2020-02
      DOI: 10.1016/j.kint.2019.11.015
      Issue No: Vol. 97, No. 2 (2020)
  • Air embolism from pericatheter air leak
    • Authors: Tuncay Sahutoglu
      First page: 425
      Abstract: A 25-year-old male with end-stage kidney disease from obstructive uropathy and neurogenic bladder presented to the emergency room with generalized tonic-clonic seizures. Two weeks before this presentation, the patient was started on hemodialysis via nontunneled precurved hemodialysis catheter, which was inserted into the right internal jugular vein. A cranial computed tomography obtained for the seizures revealed subcutaneous emphysema of the scalp and air bubbles within the dural venous sinuses (Figure 1a).
      Citation: Kidney International 97, 2 (2020)
      PubDate: 2020-02
      DOI: 10.1016/j.kint.2019.09.009
      Issue No: Vol. 97, No. 2 (2020)
  • X-linked Alport syndrome with “empty capsule sign”
    • Authors: Satoru Kudose; Ibrahim Batal, Cynthia D’Alessandri-Silva, Fangming Lin, Vivette D. D’Agati, Glen S. Markowitz
      First page: 426
      Abstract: A 4-year-old white boy with a 10-month history of microhematuria presented with episodes of gross hematuria. The patient’s mother had a history of “chronic glomerulonephritis” diagnosed on renal biopsy many years earlier. The patient had serum creatinine of 0.3 mg/dl, 24-hour urine protein of 0.6 g, serum albumin of 3.9 g/dl, no edema, normal blood pressure, negative antinuclear antibodies, and normal serum complements.
      Citation: Kidney International 97, 2 (2020)
      PubDate: 2020-02
      DOI: 10.1016/j.kint.2019.08.025
      Issue No: Vol. 97, No. 2 (2020)
  • The Case Glomerulonephritis with prolonged recurrent fever
    • Authors: Jiale Tang; Zhonghua Liao, Ting Meng, Jianping Ning, Xiangcheng Xiao, Qiaoling Zhou, Xiaozhao Li
      Pages: 427 - 428
      Abstract: A 52-year-old farmer was admitted with recurrent fever for >1 year, hematuria, proteinuria, renal insufficiency, and anemia for 4 months. He lost 15 kg over 1 year. He was employed in the animal husbandry industry including breeding of cattle and sheep and slaughtering cattle. On admission, the patient was afebrile and his blood pressure was 110/70 mm Hg. Physical examination revealed 3 enlarged lymph nodes bilaterally in the inguinal area and was otherwise normal.
      Citation: Kidney International 97, 2 (2020)
      PubDate: 2020-02
      DOI: 10.1016/j.kint.2019.08.003
      Issue No: Vol. 97, No. 2 (2020)
  • The Case Knee pain and allograft dysfunction in a kidney transplant
    • Authors: Samantha E. Jacobs; Kyriakos A. Kirou, Surya V. Seshan, Thomas J. Walsh, Choli Hartono
      Pages: 429 - 430
      Abstract: A 72-year-old man was admitted to the hospital with diabetic ketoacidosis and acute kidney injury 3 months after receiving a deceased-donor kidney transplant. He had undergone induction immunosuppression with rabbit-antithymocyte globulin and took tacrolimus and mycophenolic acid for maintenance immunosuppression. Twelve days prior to admission to the hospital, right knee pain and swelling developed. Synovial fluid was aspirated and showed a white blood cell count of 1825, 61% polymorphonuclear neutrophils, and monosodium urate crystals visualized by polarizing light microscopy.
      Citation: Kidney International 97, 2 (2020)
      PubDate: 2020-02
      DOI: 10.1016/j.kint.2019.07.007
      Issue No: Vol. 97, No. 2 (2020)
  • Renal TNFα activates the WNK phosphorylation cascade and contributes to
           salt-sensitive hypertension in chronic kidney disease
    • Authors: Taisuke Furusho; Eisei Sohara, Shintaro Mandai, Hiroaki Kikuchi, Naohiro Takahashi, Takuya Fujimaru, Hiroko Hashimoto, Yohei Arai, Fumiaki Ando, Moko Zeniya, Takayasu Mori, Koichiro Susa, Kiyoshi Isobe, Naohiro Nomura, Kohei Yamamoto, Tomokazu Okado, Tatemitsu Rai, Shinichi Uchida
      Abstract: The inappropriate over-activation of the with-no-lysine kinase (WNK)–STE20/SPS1–related proline/alanine-rich kinase (SPAK)–sodium chloride cotransporter (NCC) phosphorylation cascade increases sodium reabsorption in distal kidney nephrons, resulting in salt-sensitive hypertension. Although chronic kidney disease (CKD) is a common cause of salt-sensitive hypertension, the involvement of the WNK phosphorylation cascade is unknown. Moreover, the effect of immune systems on WNK kinases has not been investigated despite the fact that immune systems are important for salt sensitivity.
      Citation: Kidney International (2020)
      PubDate: 2020-02-11
      DOI: 10.1016/j.kint.2019.11.021
  • The spectrum of kidney biopsy findings in HIV-infected patients in the
           modern era
    • Authors: Satoru Kudose; Dominick Santoriello, Andrew S. Bomback, M. Barry Stokes, Ibrahim Batal, Glen S. Markowitz, Christina M. Wyatt, Vivette D. D’Agati
      Abstract: HIV-associated kidney disease is evolving rapidly. Few North American studies have addressedmodern trends and none has applied the 2018 Kidney Disease Improving Global Outcomes (KDIGO) pathologic classification. Therefore we performed a retrospective clinical-pathologic analysis of all HIV-positive patients with kidney biopsy interpreted at Columbia University from 2010-2018 using the KDIGO classification. The biopsy cohort of 437 HIV-positive patients had median age 53 years, including 66% males, 80% on anti-retroviral therapy, 57% with hypertension, 31% with diabetes, 27% with hepatitis C and 6% with hepatitis B co-infections.
      Citation: Kidney International (2020)
      PubDate: 2020-02-03
      DOI: 10.1016/j.kint.2020.01.018
  • A prospective controlled study of metabolic and physiologic effects of
           kidney donation suggests that donors retain stable kidney function over
           the first nine years.
    • Authors: Bertram L. Kasiske; Tracy L. Anderson-Haag, Daniel A. Duprez, Roberto S. Kalil, Paul L. Kimmel, Todd E. Pesavento, Jon J. Snyder, Matthew R. Weir
      Abstract: While there have been numerous studies of living kidney donors, most have been retrospective without suitable controls and have yielded conflicting results. To clarify this we studied 205 living donor candidates and 203 controls having no medical conditions precluding donation. Before and at six months, one, two, three, six, and nine years after donation we measured iohexol glomerular filtration rate, clinic blood pressure, urine protein excretion and metabolic parameters reported to be affected by kidney function.
      Citation: Kidney International (2020)
      PubDate: 2020-02-03
      DOI: 10.1016/j.kint.2020.01.017
  • Five year kidney outcomes of bariatric surgery differ in severely obese
           adolescents and adults with and without type 2 diabetes.
    • Authors: P. Bjornstad; E. Nehus, T. Jenkins, M. Mitsnefes, M. Moxey-Mims, J.B. Dixon, T. Inge
      Abstract: Bariatric surgery improves markers of kidney health in severe obesity, yet it is unclear if kidneydisease outcomes differ according to age at surgery. Therefore, we examined health effects of Roux-en-Y gastric bypass between 161 adolescents and 396 adults participating in two related but distinct studies. Primary outcomes were elevated urine albumin-to-creatinine ratio (UACR) of 30mg/g or more and hyperfiltration (an estimated glomerular filtration rate of 135 ml/min/1.73m2 or more). Analyses were stratified by the presence of pre-operative type 2 diabetes.
      Citation: Kidney International (2020)
      PubDate: 2020-02-03
      DOI: 10.1016/j.kint.2020.01.016
  • IL-17C has a pathogenic role in kidney ischemia/reperfusion Injury
    • Authors: Feng Wang; Jianyong Yin, Yingying Lin, Fangfei Zhang, Xuanchen Liu, Guangyuan Zhang, Yiwei Kong, Zeyuan Lu, Rui Wu, Niansong Wang, Tao Xing, Youcun Qian
      Abstract: Cytokines are necessary to trigger the inflammatory response in kidney ischemia/reperfusion injury. Interleukin-17C (IL-17C), a unique member of the IL-17 family, is a cytokine produced by epithelial cells implicated in host defense and autoimmune diseases. However, little is known about the role of IL-17C in acute kidney injury. We investigated this and found that IL-17C was significantly increased kidney biopsies of patients and mice with acute kidney injury. Exposure to hypoxia induced upregulation of IL-17C in kidney tubular epithelial cells.
      Citation: Kidney International (2020)
      PubDate: 2020-02-03
      DOI: 10.1016/j.kint.2020.01.015
  • Anti-CD20-mediated B-cell depletion in auto-immune diseases: successes,
           failures and future perspectives.
    • Authors: Etienne Crickx; Jean-Claude Weill, Claude-Agnès Reynaud, Matthieu Mahévas
      Abstract: B-cell depletion with anti-CD20 monoclonal antibodies is widely used for the treatment of auto-immune diseases. In this review, we will discuss mechanisms contributing to success or failure of B-cell depletion therapy in antibody-mediated auto-immune diseases. We will also explain how key informations about disease pathogeny can be provided by the different outcomes observed after B-cell depletion therapy. These findings provide the basis for future innovative therapeutic strategies aiming at an optimized B cell and/or plasma cell depletion to increase long-term disease remission.
      Citation: Kidney International (2020)
      PubDate: 2020-01-30
      DOI: 10.1016/j.kint.2019.12.025
  • How to assess kidney function in oncology patients
    • Authors: Jolanta Malyszko; Michael W. Lee, Giovambattista Capasso, Pawel Kulicki, Joanna Matuszkiewicz-Rowinska, Pierre Ronco, Paul Stevens, Petra Tesarova, Davide Viggiano, Anna Capasso
      Abstract: Assessment of kidney function in oncology patients is a fundamental factor in profiling the survival risk, determining the appropriate dose of chemotherapeutic drugs and defining a patient eligibility for clinical trials with novel agents. Both overestimation and underestimation of kidney function may affect the treatment efficacy and outcomes. Overestimation may lead to overdosing or inappropriate agent selection and corresponding toxicity, while underestimation may be responsible for underdosing or inappropriate agent exclusion and subsequent treatment failure.
      Citation: Kidney International (2020)
      PubDate: 2020-01-29
      DOI: 10.1016/j.kint.2019.12.023
  • Mesenchymal Stromal Cell-Based Therapies for Acute Kidney Injury: Progress
           in the Last Decade
    • Authors: Barbara Fazekas; Matthew D. Griffin
      Abstract: A little over 10 years ago, the therapeutic potential of mesenchymal stromal cells (MSC) for the treatment of acute kidney injury (AKI) was becoming widely recognized. Since then, there has been further intensive study of this topic with a clear translational intent. Over the past decade, many more animal model studies have strengthened the evidence that systemically or locally-delivered MSC ameliorate renal injury in sterile and sepsis-associated AKI (SA-AKI). Some of these pre-clinical studies have also provided a range of compelling new insights into the in vivo fate and mechanisms of action of MSC in the setting of AKI and other inflammatory conditions.
      Citation: Kidney International (2020)
      PubDate: 2020-01-28
      DOI: 10.1016/j.kint.2019.12.019
  • Collecting system specific deletion of Kcnj10 predisposes for thiazide-
           and low potassium diet-induced hypokalemia.
    • Authors: David Penton; Twinkle Vohra, Eszter Banki, Agnieszka Wengi, Maria Weigert, Anna-Lena Forst, Sascha Bandulik, Richard Warth, Johannes Loffing
      Abstract: The basolateral potassium channel KCNJ10 (Kir4.1), is expressed in the renal distal convoluted tubule and controls the activity of the thiazide-sensitive sodium chloride cotransporter. Loss-of-function mutations of KCNJ10 cause EAST/SeSAME syndrome with salt wasting and severe hypokalemia. KCNJ10 is also expressed in the principal cells of the collecting system. However, its pathophysiological role in this segment has not been studied in detail. To address this, we generated the mouse model AQP2cre:Kcnj10flox/flox with a deletion of Kcnj10 specifically in the collecting system (collecting system-Kcnj10-knockout).
      Citation: Kidney International (2020)
      PubDate: 2020-01-17
      DOI: 10.1016/j.kint.2019.12.016
  • A multicenter, randomized, placebo-controlled, double-blind phase 3 trial
           with open-arm comparison indicates safety and efficacy of nephroprotective
           therapy with ramipril in children with Alport’s syndrome.
    • Authors: Oliver Gross; Burkhard Tönshoff, Lutz T. Weber, Lars Pape, Kay Latta, Henry Fehrenbach, Baerbel Lange-Sperandio, Hildegard Zappel, Peter Hoyer, Hagen Staude, Sabine König, Ulrike John, Jutta Gellermann, Bernd Hoppe, Matthias Galiano, Britta Hoecker, Rasmus Ehren, Christian Lerch, Clifford E. Kashtan, Markus Harden, Jan Boeckhaus, Tim Friede, GPN Study Group EARLY PRO-TECT Alport investigators
      Abstract: Children with Alport syndrome develop renal failure early in life. Since the safety and efficacy of preemptive nephroprotective therapy are uncertain we conducted a randomized, placebo-controlled, double-blind trial in 14 German sites of pediatric patients with ramipril for three to six years plus six months follow-up to determine these parameters. Pretreated children and those whose parents refused randomization became an open-arm control, which were compared to prospective real-world data from untreated children.
      Citation: Kidney International (2020)
      PubDate: 2020-01-17
      DOI: 10.1016/j.kint.2019.12.015
  • Spleen tyrosine kinase inhibition is an effective treatment for
           established vasculitis in a pre-clinical model.
    • Authors: Stephen P. McAdoo; Maria Prendecki, Anisha Tanna, Tejal Bhatt, Gurjeet Bhangal, John McDaid, Esteban S. Masuda, H. Terence Cook, Frederick WK. Tam, Charles D. Pusey
      Abstract: The anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitides (AAV) are a group of life-threatening multi-system diseases characterized by necrotising inflammation of small blood vessels and crescentic glomerulonephritis. ANCA are thought to play a direct pathogenic role. Previous studies have shown that spleen tyrosine kinase (SYK) is phosphorylated during ANCA-induced neutrophil activation in vitro. However, the role of SKY in vivo is unknown. Here, we studied its role in the pathogenesis of experimental autoimmune vasculitis, a pre-clinical model of myeloperoxidase-ANCA-induced pauci-immune systemic vasculitis in the Wistar Kyoto rat.
      Citation: Kidney International (2020)
      PubDate: 2020-01-16
      DOI: 10.1016/j.kint.2019.12.014
  • Electronic health records for the diagnosis of rare diseases
    • Authors: Nicolas Garcelon; Anita Burgun, Rémi Salomon, Antoine Neuraz
      Abstract: With the emergence of electronic health records, the reuse of clinical data offers new perspectives for the diagnosis and management of patients with rare diseases. However, there are many locks for the repurposing of clinical data. The development of decision support systems depends on the ability: to recruit patients; then to extract and integrate the patients’ data; to mine and stratify these data; and to integrate the decision support algorithm into the patient care. This last step requires an adaptability of the electronic health records to integrate learning health system tools.
      Citation: Kidney International (2020)
      PubDate: 2020-01-13
      DOI: 10.1016/j.kint.2019.11.037
  • The circadian clock is disrupted in mice with adenine-induced
           tubulointerstitial nephropathy
    • Authors: Hiroaki Motohashi; Yu Tahara, Daniel S. Whittaker, Huei-Bin Wang, Takahiro Yamaji, Hiromichi Wakui, Atsushi Haraguchi, Mayu Yamazaki, Hiroki Miyakawa, Koki Hama, Hiroyuki Sasaki, Tomoko Sakai, Rina Hirooka, Kengo Takahashi, Miku Takizawa, Saneyuki Makino, Shinya Aoyama, Christopher S. Colwell, Shigenobu Shibata
      Abstract: Chronic Kidney Disease (CKD) is increasing in incidence and has become a worldwide health problem. Sleep disorders are prevalent in patients with CKD raising the possibility that these patients have a disorganized circadian timing system. Here, we examined the effect of adenine-induced tubulointerstitial nephropathy on the circadian system in mice. Compared to controls, adenine-treated mice showed serum biochemistry evidence of CKD as well as increased kidney expression of inflammation and fibrosis markers.
      Citation: Kidney International (2020)
      PubDate: 2020-01-13
      DOI: 10.1016/j.kint.2019.09.032
  • Health disparities in access to kidney replacement therapy amongst
           children and adolescents with end stage kidney disease in low- and
           lower-middle income countries
    • Authors: Rowena Lalji; Anna Francis, David W. Johnson, Mignon McCulloch
      Abstract: Many health disparities exist between children of low and lower-middle income countries (LLMIC) when compared to their high-income country (HIC) counterparts due to a complex interplay of resource constraints and epidemiological, biological and social factors. A lack of adequate infrastructure, clean water and access to physicians and essential medicines in addition to high rates of prematurity, low birth weight and poor nutrition place children from LLMIC at significant risk of mortality and kidney morbidity.
      Citation: Kidney International (2020)
      PubDate: 2020-01-09
      DOI: 10.1016/j.kint.2019.11.030
  • Coronary Artery Disease in Chronic Kidney Disease: Highlights from a
           Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference
    • Authors: Daniel Edmonston; Patrick Pun
      Abstract: The risk of coronary artery disease (CAD) increases as chronic kidney disease (CKD) advances, despite adjustment for traditional cardiovascular risk factors.1 Conventional therapies have failed to improve these outcomes, especially in patients with end-stage kidney disease (ESKD).2 The abrupt decline in CAD risk after kidney transplant, despite years of exposure to traditional CAD risk factors, suggests a role for reversible factors associated with ESKD and dialysis. Here, we briefly highlight select topics from the recent Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference on CAD in CKD.
      Citation: Kidney International (2019)
      PubDate: 2019-12-28
      DOI: 10.1016/j.kint.2019.12.010
  • Transgenic zebrafish modeling low-molecular weight proteinuria and
           lysosomal storage disease
    • Authors: Zhiyong Chen; Alessandro Luciani, José María Mateos, Gery Barmettler, Rachel H. Giles, Stephan C.F. Neuhauss, Olivier Devuyst
      Abstract: Epithelial cells lining the proximal tubule of the kidney reabsorb and metabolize most of the filtered low-molecular-weight proteins through receptor-mediated endocytosis and lysosomal processing. Congenital and acquired dysfunctions of the proximal tubule are consistently reflected by the inappropriate loss of solutes including low-molecular-weight proteins in the urine. The zebrafish pronephros shares individual functional segments with the human nephron, including lrp2a/megalin-dependent endocytic transport processes of the proximal tubule.
      Citation: Kidney International (2019)
      PubDate: 2019-12-27
      DOI: 10.1016/j.kint.2019.11.016
  • Role of Direct Oral Anticoagulants in Patients with Kidney Disease
    • Authors: Vimal K. Derebail; Michelle N. Rheault, Bryce A. Kerlin
      Abstract: The anticoagulation field is experiencing a renaissance that began with regulatory approval of the direct thrombin inhibitor, dabigatran, a Direct Oral Anticoagulant (DOAC) in 2010. The DOAC medication class has rapidly evolved to include the additional approval of four direct factor Xa inhibitors. Commensurately, DOAC utilization has grown and collectively account for the majority of new anticoagulant prescriptions. Despite exclusion of moderate-to-severe kidney disease patients from most DOAC pivotal trials, DOACs are increasingly utilized in this setting.
      Citation: Kidney International (2019)
      PubDate: 2019-12-24
      DOI: 10.1016/j.kint.2019.11.027
  • The oral hypoxia-inducible factor prolyl hydroxylase inhibitor enarodustat
           counteracts alterations in renal energy metabolism in the early stages of
           diabetic kidney disease
    • Authors: Sho Hasegawa; Tetsuhiro Tanaka, Tomoyuki Saito, Kenji Fukui, Takeshi Wakashima, Etsuo A. Susaki, Hiroki R. Ueda, Masaomi Nangaku
      Abstract: Hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors, also known as HIF stabilizers, increase endogenous erythropoietin production and serve as novel therapeutic agents against anemia in chronic kidney disease. HIF induces the expression of various genes related to energy metabolism as an adaptive response to hypoxia. However, it remains obscure how the metabolic reprogramming in renal tissue by HIF stabilization affects the pathophysiology of kidney diseases. Previous studies suggest that systemic metabolic disorders such as hyperglycemia and dyslipidemia cause alterations of renal metabolism, leading to renal dysfunction including diabetic kidney disease.
      Citation: Kidney International (2019)
      PubDate: 2019-12-24
      DOI: 10.1016/j.kint.2019.12.007
  • The proton-activated ovarian cancer G protein-coupled receptor 1 (OGR1) is
           responsible for renal calcium loss during acidosis.
    • Authors: Pedro Henrique Imenez Silva; Chahira Katamesh-Benabbas, Kessara Chan, Eva Maria Pastor Arroyo, Thomas Knöpfel, Carla Bettoni, Marie-Gabrielle Ludwig, Jürg A. Gasser, Andrea Brandao-Burch, Timothy R. Arnett, Olivier Bonny, Klaus Seuwen, Carsten Alexander Wagner
      Abstract: Hypercalciuria is a common feature during metabolic acidosis and associates to nephrolithiasis and nephrocalcinosis. The mechanisms sensing acidosis and inducing increased urinary calcium excretion are still unknown. Here we tested whether mice deficient for proton-activated Ovarian cancer G-protein coupled receptor 1 (OGR1 or Gpr68) have reduced urinary excretion of calcium during chronic metabolic acidosis. In the kidney, OGR1 mRNA was found in cells of the glomerulus, proximal tubule, and interstitium including endothelial cells.
      Citation: Kidney International (2019)
      PubDate: 2019-12-24
      DOI: 10.1016/j.kint.2019.12.006
  • Tubule-derived exosomes play a central role in fibroblast activation and
           kidney fibrosis
    • Authors: Xi Liu; Jinhua Miao, Cong Wang, Shan Zhou, Shuangqin Chen, Qian Ren, Xue Hong, Yongping Wang, Fan Fan Hou, Lili Zhou, Youhua Liu
      Abstract: Extracellular vesicles such as exosomes are involved in mediating cell-cell communication by shuttling an assortment of proteins and genetic information. Here, we tested whether renal tubule-derived exosomes play a central role in mediating kidney fibrosis. The production of exosomes was found to be increased in the early stage of unilateral ureteral obstruction, ischemia reperfusion injury or 5/6 nephrectomy models of kidney disease. Exosome production occurred primarily in renal proximal tubular epithelium and was accompanied by induction of sonic hedgehog (Shh).
      Citation: Kidney International (2019)
      PubDate: 2019-12-17
      DOI: 10.1016/j.kint.2019.11.026
  • Kidney residency of VISTA-positive macrophages accelerates repair from
           ischemic injury
    • Authors: Jun-Gyu Park; Cho-Rong Lee, Min-Gang Kim, Gwanghun Kim, Hyun Mu Shin, Yun-Hui Jeon, Seung Hee Yang, Dong Ki Kim, Wook Joo Kwon, Eun Young Choi, Hang-Rae Kim, Cheol Kwak, Yon Su Kim, Murim Choi, Dong-Sup Lee, Seung Seok Han
      Abstract: Tissue-resident macrophages have unique tissue-specific functions in maintaining homeostasis and resolving inflammation. However, the repair role and relevant molecules of kidney-resident macrophages after ischemic injury remain unresolved. To this end, mice without kidney-resident R1 macrophages but containing infiltrating monocyte-derived R2 macrophages were generated using differential cellular kinetics following clodronate liposome treatment. When ischemia-reperfusion injury was induced in these mice, late phase repair was reduced.
      Citation: Kidney International (2019)
      PubDate: 2019-12-17
      DOI: 10.1016/j.kint.2019.11.025
  • Lipopolysaccharide induces filtrate leakage from renal tubular lumina into
           the interstitial space via a proximal tubular Toll-like receptor
           4-dependent pathway and limits sensitivity to fluid therapy in mice.
    • Authors: Daisuke Nakano; Kento Kitada, Ningning Wan, Yahua Zhang, Helge Wiig, Kittikulsuth Wararat, Motoko Yanagita, Syann Lee, Lin Jia, Jens M. Titze, Akira Nishiyama
      Abstract: Sustained oliguria during fluid resuscitation represents a perplexing problem in patients undergoing therapy for septic acute kidney injury. Here, we tested whether lipopolysaccharide induces filtrate leakage from the proximal tubular lumen into the interstitium, thus disturbing the recovery of urine output during therapy, such as fluid resuscitation, aiming to restore the glomerular filtration rate. Intravital imaging of the tubular flow rate in the proximal tubules in mice showed that lipopolysaccharide did not change the inflow rate of proximal tubule filtrate, reflecting an unchanged glomerular filtration rate, but significantly reduced the outflow rate, resulting in oliguria.
      Citation: Kidney International (2019)
      PubDate: 2019-12-17
      DOI: 10.1016/j.kint.2019.11.024
  • Clinical features of genetically-confirmed patients with primary
    • Authors: David J. Sas; Felicity T. Enders, Ramila A. Mehta, Xiaojing Tang, Fang Zhao, Barbara M. Seide, Dawn S. Milliner, John C. Lieske
      Abstract: Primary hyperoxaluria is a rare monogenic disorder characterized by excessive hepatic production of oxalate leading to recurrent nephrolithiasis, nephrocalcinosis and progressive kidney damage. Most patients with primary hyperoxaluria are diagnosed after clinical suspicion based on symptoms. Since some patients are detected by family screening following detection of an affected family member, we compared the clinical phenotype of these two groups. Patients with primary hyperoxaluria types 1, 2, and 3 enrolled in the Rare Kidney Stone Consortium Primary Hyperoxaluria Registry were retrospectively analyzed following capture of clinical and laboratory results in the Registry.
      Citation: Kidney International (2019)
      PubDate: 2019-12-13
      DOI: 10.1016/j.kint.2019.11.023
  • In a Phase 1a escalating clinical trial, autologous mesenchymal stem cell
           infusion for renovascular disease increases blood flow and the glomerular
    • Authors: Abdelrhman Abumoawad; Ahmed Saad, Christopher M. Ferguson, Alfonso Eirin, Sandra M. Herrmann, LaTonya J. Hickson, Busra B. Goksu, Emily Bendel, Sanjay Misra, James Glockner, Allan B. Dietz, Lilach O. Lerman, Stephen C. Textor
      Abstract: Atherosclerotic renovascular disease (ARVD) reduces tissue perfusion and eventually leads to loss of kidney function with limited therapeutic options. Here we describe results of Phase 1a escalating dose clinical trial of autologous mesenchymal stem cell infusion for ARVD. Thirty-nine patients with ARVD were studied on two occasions separated by three months. Autologous adipose-derived mesenchymal stem cells were infused through the renal artery in 21 patients at three different dose levels (1, 2.5 and 5.0 x 105 cells/kg) in seven patients each.
      Citation: Kidney International (2019)
      PubDate: 2019-12-13
      DOI: 10.1016/j.kint.2019.11.022
  • IL-6-mediated hepatocyte production is the primary source of plasma and
           urine neutrophil gelatinase associated lipocalin during acute kidney
    • Authors: Nataliya I. Skrypnyk; Katja M. Gist, Kayo Okamura, John R. Montford, Zhiying You, Haichun Yang, Radu Moldovan, Evelyn Bodoni, Judith T. Blaine, Charles L. Edelstein, Danielle E. Soranno, Lara A. Kirkbride-Romeo, Benjamin R. Griffin, Chris Altmann, Sarah Faubel
      Abstract: Neutrophil gelatinase associated lipocalin (NGAL, Lcn2) is the most widely studied biomarker of acute kidney injury (AKI). Previous studies have demonstrated that NGAL is produced by thekidney and released into the urine and plasma. Consequently, NGAL is currently considered a tubule specific injury marker of AKI. However, the utility of NGAL to predict AKI has been variable suggesting that other mechanisms of production are present. IL-6 is a proinflammatory cytokine increased in plasma by two hours of AKI and mediates distant organ effects.
      Citation: Kidney International (2019)
      PubDate: 2019-11-28
      DOI: 10.1016/j.kint.2019.11.013
  • Cadmium exposure enhances organic cation transporter 2 trafficking to the
           kidney membrane and exacerbates cisplatin nephrotoxicity
    • Authors: Hong Yang; Jie Tang, Dong Guo, Qingqing Zhao, Jiagen Wen, Yanjuan Zhang, Obinna N. Obianom, Shiwei Zhou, Wei Zhang, Yan Shu
      Abstract: Renal accumulation and exposure of cadmium originating from pollution in agricultural land and the prevalence of cigarette smoking remains an unneglectable human health concern. Whereas cadmium exposure has been correlated with increased incidence of a variety of kidney diseases, little is known pertaining to its effect on renal drug disposition and response in patients. Here, we report that cadmium exposure significantly increased the activity of organic cation transporter 2 (OCT2), a critical renal drug transporter recommended in United States Federal Drug Administration guidance for assessment during drug development.
      Citation: Kidney International (2019)
      PubDate: 2019-11-26
      DOI: 10.1016/j.kint.2019.11.012
  • Epidemiology research to foster improvement in chronic kidney disease care
    • Authors: Shengyuan Luo; Morgan E. Grams
      Abstract: With the growing availability of linked electronic health records, long-running cohorts, and high-throughput technologies, the potential for epidemiology research to improve the care of patients with kidney disease is greater than ever before. In this review, we highlight the application of epidemiology techniques to identify, evaluate, and address chronic kidney disease. We discuss studies that inform guidelines, identify health disparities, evaluate the genetic basis of disease, and relate -omic data such as proteomics, metabolomics, and genetics to outcomes.
      Citation: Kidney International (2019)
      PubDate: 2019-11-26
      DOI: 10.1016/j.kint.2019.11.010
  • The zinc fingers and homeoboxes 2 protein ZHX2 and its interacting
           proteins regulate upstream pathways in podocyte diseases.
    • Authors: Camille Macé; Maria Del Nogal Avila, Caroline B. Marshall, Joubert Kharlyngdoh, Ranjan Das, Eduardo Molina-Jijon, Hector Donoro Blazquez, Suresh Shastry, Elisabeth Soria, Jack Wetzels, Henry Dijkman, Carmen Avila-Casado, Lionel C. Clement, Sumant S. Chugh
      Abstract: Zinc fingers and homeoboxes (ZHX) proteins are heterodimeric transcriptional factors largely expressed at the cell membrane in podocytes in vivo. We found ZHX2-based heterodimers in podocytes, with ZHX2-ZHX1 predominantly at the cell membrane of the podocyte cell body, and ZHX2-ZHX3 at the slit diaphragm. In addition to changes in overall ZHX2 expression, there was increased podocyte nuclear ZHX3 and ZHX2 in patients with focal segmental glomerulosclerosis, and increased podocyte nuclear ZHX1 in patients with minimal change disease .
      Citation: Kidney International (2019)
      PubDate: 2019-11-25
      DOI: 10.1016/j.kint.2019.11.011
  • Cross-talk between the nervous system and the kidney
    • Authors: Shinji Tanaka; Mark D. Okusa
      Abstract: Under physiological states, the nervous system and the kidneys communicate with each other to maintain normal body homeostasis. However, pathological states disrupt this interaction as seen in hypertension, and kidney damage can cause impaired renorenal reflex and sodium handling. In acute kidney injury (AKI) and chronic kidney disease (CKD), damaged kidneys can have a detrimental effect on the central nervous system. CKD is an independent risk factor for cerebrovascular disease and cognitive impairment, and many factors, including retention of uremic toxins and phosphate, have been proposed as CKD-specific factors responsible for structural and functional cerebral changes in patients with CKD.
      Citation: Kidney International (2019)
      PubDate: 2019-11-22
  • Symmetric dimethylarginine in dysfunctional high-density lipoprotein
           mediates endothelial glycocalyx breakdown in chronic kidney disease.
    • Authors: Bettina Hesse; Alexandros Rovas, Konrad Buscher, Kristina Kusche-Vihrog, Marcus Brand, Giovana Seno Di Marco, Jan T. Kielstein, Renke Maas, Hermann Pavenstädt, Wolfgang A. Linke, Jerzy-Roch Nofer, Philipp Kümpers, Alexander Lukasz
      Abstract: Dysfunctional high-density lipoprotein (d-HDL) in chronic kidney disease is known to have a change in composition towards an endothelial-damaging phenotype, amongst others, via the accumulation of symmetric dimethylarginine. The endothelial glycocalyx, a carbohydrate-rich layer lining the endothelial luminal surface, is a first line defense against vascular diseases including atherosclerosis. Here we conducted a translational, cross-sectional study to determine the role of symmetric dimethylarginine in d-HDL as a mediator of glycocalyx damage.
      Citation: Kidney International (2019)
      PubDate: 2019-11-13
  • Epitopes as characterized by antibody-verified eplet mismatches determine
           risk of kidney transplant loss
    • Authors: Ruth Sapir-Pichhadze; Xun Zhang, Abdelhakim Ferradji, Abeer Madbouly, Kathryn Tinckam, Howard Gebel, Daniel Blum, Marilyn Marrari, S Joseph Kim, Stephanie Fingerson, Pradeep Bashyal, Héloïse Cardinal, Bethany Foster
      Abstract: To optimize strategies that mitigate the risk of graft loss associated with HLA incompatibility, we evaluated whether sequence defined HLA targets (eplets) that result in donor-specific antibodies are associated with transplant outcomes. To define this, we fit multivariable Cox proportional hazard models in a cohort of 118 382 United States first kidney transplant recipients to assess risk of death-censored graft failure by increments of ten antibody-verified eplet mismatches. To verify robustness of our findings, we conducted sensitivity analysis in this United States cohort and assessed the role of antibody-verified eplet mismatches as autonomous predictors of transplant glomerulopathy in an independent Canadian cohort.
      Citation: Kidney International (2019)
      PubDate: 2019-11-12
  • Light chain only variant of proliferative glomerulonephritis with
           monoclonal immunoglobulin deposits is associated with a high detection
           rate of the pathogenic plasma cell clone
    • Authors: Samih H. Nasr; Christopher P. Larsen, Christophe Sirac, Jason D. Theis, Camille Domenger, Sophie Chauvet, Vincent Javaugue, Jonathan J. Hogan, Samar M. Said, Surendra Dasari, Julie A. Vrana, Ellen D. McPhail, Lynn D. Cornell, Eve Vilaine, Ziad A. Massy, Jean-Jacques Boffa, David Buob, Stéphanie Toussaint, Thomas Guincestre, Guy Touchard, Vivette D. D’Agati, Nelson Leung, Frank Bridoux
      Abstract: IgG (mainly IgG3) is the most commonly involved isotype in proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID). Here we describe the first series of PGNMID with deposition of monoclonal immunoglobulin light chain only (PGNMID-light chain). This multicenter cohort of 17 patients presented with nephritic or nephrotic syndrome with underlying hematologic conditions of monoclonal gammopathy of renal significance (71%) or multiple myeloma (29%). Monoclonal immunoglobulin was identified by serum and urine immunofixation in 65% and 73%, respectively, with abnormal serum free light chain in 83%, and a detectable bone marrow plasma cell clone in 88% of patients.
      Citation: Kidney International (2019)
      PubDate: 2019-11-09
  • Serum amyloid P deposition is a sensitive and specific feature of
           membranous-like glomerulopathy with masked IgG kappa deposits.
    • Authors: Christopher P. Larsen; Shree G. Sharma, Tiffany N. Caza, Daniel J. Kenan, Aaron J. Storey, Ricky D. Edmondson, Christian Herzog, John M. Arthur
      Abstract: Membranous-like glomerulopathy with masked IgG kappa deposits (MGMID) is a recently described pattern of glomerulonephritis with a unique histopathology. The pattern is characterized by subepithelial and/or mesangial immune deposits that are “masked”, to immunoglobulin staining by routine immunofluorescence but strongly stain for IgG and kappa light chain after protease digestion. Patients with this pattern of glomerulonephritis are most commonly young females presenting with proteinuria and a vague history of autoimmune disease such as low titer antinuclear antibodies.
      Citation: Kidney International (2019)
      PubDate: 2019-11-08
  • The nucleic acid binding protein YB-1-controlled expression of CXCL-1
           modulates kidney damage in liver fibrosis.
    • Authors: Daniela Hermert; Ina V. Martin, Lucy K. Reiss, Xiyang Liu, Daniel M. Breitkopf, Katharina Charlotte Reimer, Christina Alidousty, Thomas Rauen, Jürgen Floege, Tammo Ostendorf, Ralf Weiskirchen, Ute Raffetseder
      Abstract: Acute kidney injury is a common complication of advanced liver disease and increased mortality of these patients. Here, we analyzed the role of Y-box protein-1 (YB-1), a nucleic acid binding protein, in the bile duct ligation model of liver fibrosis and monitored liver and subsequent kidney damage. Following bile duct ligation, both serum levels of liver enzymes and expression of hepatic extracellular matrix components such as type I collagen were significantly reduced in mice with half-maximal YB-1 expression (Yb1+/-) as compared to their wild-type littermates.
      Citation: Kidney International (2019)
      PubDate: 2019-11-08
  • A novel mouse model of phospholipase A2 receptor 1-associated membranous
           nephropathy mimics podocyte injury in patients
    • Authors: Catherine Meyer-Schwesinger; Nicola M. Tomas, Silke Dehde, Larissa Seifert, Irm Hermans-Borgmeyer, Thorsten Wiech, Friedrich Koch-Nolte, Tobias B. Huber, Gunther Zahner
      Abstract: The phospholipase A2 receptor 1 (PLA2R1) is the major autoantigen in patients suffering from membranous nephropathy. To date, the lack of endogenous glomerular expression of PLA2R1 in mice and rats has impeded the establishment of PLA2R1-dependent animal models of this disease. Here, we generated a transgenic mouse line expressing murine full-length PLA2R1 in podocytes. Furthermore, expression of murine PLA2R1 did not result in any morphological disturbance as high-resolution confocal microscopy demonstrated an intact nephrin distribution with normal foot processes.
      Citation: Kidney International (2019)
      PubDate: 2019-11-07
  • Prolyl hydroxylase inhibition protects the kidneys from ischemia via
           upregulation of glycogen storage
    • Authors: Marie Ito; Tetsuhiro Tanaka, Taisuke Ishii, Takeshi Wakashima, Kenji Fukui, Masaomi Nangaku
      Abstract: Hypoxia-inducible factor (HIF) mediates protection via hypoxic preconditioning in both, in vitro and in vivo ischemia models. However, the underlying mechanism remains largely unknown. Prolyl hydroxylase domain proteins serve as the main HIF regulator via hydroxylation of HIFα leading to its degradation. At present, prolyl hydroxylase inhibitors including enarodustat are under clinical trials for the treatment of renal anemia. In an in vitro model of ischemia produced by oxygen-glucose deprivation of renal proximal tubule cells in culture, enarodustat treatment and siRNA knockdown of prolyl hydroxylase 2, but not of prolyl hydroxylase 1 or prolyl hydroxylase 3, significantly increased the cell viability and reduced the levels of reactive oxygen species.
      Citation: Kidney International (2019)
      PubDate: 2019-11-07
  • Calciprotein particles regulate fibroblast growth factor-23 expression in
    • Authors: Ken-ichi Akiyama; Yutaka Miura, Hirosaka Hayashi, Asuka Sakata, Yoshitaka Matsumura, Masaki Kojima, Ken Tsuchiya, Kosaku Nitta, Kazuhiro Shiizaki, Hiroshi Kurosu, Makoto Kuro-o
      Abstract: Fibroblast growth factor-23 (FGF23) is a hormone indispensable for maintaining phosphate homeostasis. In response to phosphate intake, FGF23 is secreted from osteocytes/osteoblasts and acts on the kidney to increase urinary phosphate excretion. However, the mechanism by which these cells sense phosphate intake remains elusive. Calciprotein particles are nanoparticles of calcium-phosphate precipitates bound to serum protein fetuin-A and are generated spontaneously in solution containing calcium, phosphate, and fetuin-A to be dispersed as colloids.
      Citation: Kidney International (2019)
      PubDate: 2019-11-07
  • Non-canonical immunomodulatory activity of complement regulator C4BP(β-)
           limits the development of lupus nephritis
    • Authors: Ana Luque; Inmaculada Serrano, Elia Ripoll, Catarina Malta, Montserrat Gomà, Anna M. Blom, Josep M. Grinyó, Santiago Rodríguez de Córdoba, Joan Torras, Josep M. Aran
      Abstract: Lupus nephritis is a chronic autoimmune-inflammatory condition that can lead to end-stage kidney disease. Presently available immunosuppressive treatments for lupus nephritis are suboptimal and can induce significant side effects. Recently, we characterized a novel immunomodulatory activity of the minor isoform of the classical pathway complement inhibitor, C4BP(β-). We show here that C4BP(β-) treatment prevented the development of proteinuria and albuminuria, decreased significantly the formation of anti-dsDNA antibodies and, locally, mitigated renal glomerular IgG and C3 deposition and generation of apoptotic cells.
      Citation: Kidney International (2019)
      PubDate: 2019-11-06
  • Blocking matrix metalloproteinase-mediated syndecan-4 shedding restores
           the endothelial glycocalyx and glomerular filtration barrier function in
           early diabetic kidney disease
    • Authors: Raina D. Ramnath; Matthew J. Butler, Georgina Newman, Sara Desideri, Amy Russell, Abigail C. Lay, Chris R. Neal, Yan Qiu, Sarah Fawaz, Karen L. Onions, Monica Gamez, Michael Crompton, Chris Michie, Natalie Finch, Richard J. Coward, Gavin I. Welsh, Rebecca R. Foster, Simon C. Satchell
      Abstract: The endothelial glycocalyx is a key component of the glomerular filtration barrier. We have shown that matrix metalloproteinase (MMP)-mediated syndecan 4 shedding is a mechanism of glomerular endothelial glycocalyx damage in vitro, resulting in increased albumin permeability.Here we sought to determine whether this mechanism is important in early diabetic kidney disease, by studying streptozotocin-induced type 1 diabetes in DBA2/J mice. Diabetic mice were albuminuric, had increased glomerular albumin permeability and endothelial glycocalyx damage.
      Citation: Kidney International (2019)
      PubDate: 2019-11-02
      DOI: 10.1016/j.kint.2019.09.035
  • Magnesium prevents vascular calcification in Klotho deficiency
    • Authors: Anique D. ter Braake; Anna E. Smit, Caro Bos, Antonius E. van Herwaarden, Wynand Alkema, Huib W. van Essen, Nathalie Bravenboer, Marc G. Vervloet, Joost G.J. Hoenderop, Jeroen H.F. de Baaij
      Abstract: Klotho knock-out mice are an important model for vascular calcification, which is associated with chronic kidney disease. In chronic kidney disease, serum magnesium inversely correlates with vascular calcification. Here we determine the effects of serum magnesium on aortic calcification in Klotho knock-out mice treated with a minimal or a high magnesium diet from birth. After eight weeks, serum biochemistry, and aorta and bone tissues were studied. Protective effects of magnesium were characterized by RNA-sequencing of the aorta and micro-CT analysis was performed to study bone integrity.
      Citation: Kidney International (2019)
      PubDate: 2019-11-02
      DOI: 10.1016/j.kint.2019.09.034
  • A prospective multi-center quality improvement initiative (NINJA)
           indicates a reduction in nephrotoxic acute kidney injury in hospitalized
    • Authors: Stuart L. Goldstein; Devesh Dahale, Eric S. Kirkendall, Theresa Mottes, Heather Kaplan, Stephen Muething, David J. Askenazi, Traci Henderson, Lynn Dill, Michael J.G. Somers, Jessica Kerr, Jennifer Gilarde, Joshua Zaritsky, Valerie Bica, Patrick D. Brophy, Jason Misurac, Richard Hackbarth, Julia Steinke, Joann Mooney, Sara Ogrin, Vimal Chadha, Bradley Warady, Richard Ogden, Wendy Hoebing, Jordan Symons, Karyn Yonekawa, Shina Menon, Lisa Abrams, Scott Sutherland, Patricia Weng, Fang Zhang, Kathleen Walsh
      Abstract: Nephrotoxic medication (NTMx) exposure is a common cause of acute kidney injury (AKI) in hospitalized children. The Nephrotoxic Injury Negated by Just-in time Action (NINJA) program decreased NTMx associated AKI (NTMx-AKI) by 62% at one center. To further test the program, we incorporated NINJA across nine centers with the goal of reducing NTMx exposure and, consequently, AKI rates across these centers. NINJA screens all non-critically ill hospitalized patients for high NTMx exposure (over three medications on the same day or an intravenous aminoglycoside over three consecutive days), and then recommends obtaining a daily serum creatinine level in exposed patients for the duration of, and two days after, exposure ending.
      Citation: Kidney International (2019)
      PubDate: 2019-11-01
  • Temporal and tissue-specific activation of aryl hydrocarbon hydroxylase
           signaling may be visualized in discrete mouse models of kidney disease
    • Authors: Joshua A. Walker; Sean Richards, Mostafa E. Belghasem, Nkiruka Arinze, Sung Bok Yoo, Joseph Y. Tashjian, Stephen A. Whelan, Norman Lee, Vijaya B. Kolachalama, Jean Francis, Katya Ravid, David Sherr, Vipul C. Chitalia
      Abstract: Emerging evidence in animal models of chronic kidney disease (CKD) implicates Aryl Hydrocarbon Receptor (AHR) signaling as a mediator of uremic toxicity. However, details about its tissue-specific and time-dependent activation in response to various renal pathologies remain poorly defined. Here, a comprehensive analysis of AHR induction was conducted in response to discrete models of kidney diseases using a transgenic mouse line expressing the AHR responsive-promoter tethered to a β-galactosidase reporter gene.
      Citation: Kidney International (2019)
      PubDate: 2019-10-29
      DOI: 10.1016/j.kint.2019.09.029
  • Scratching the itch: A new therapeutic target for dialysis-associated
    • Authors: Christina M. Wyatt; Tilman B. Drueke
      Abstract: Pruritus is common among patients with end-stage kidney disease (ESKD), affecting an estimated 55% of adults on maintenance dialysis (1). In cross-sectional studies, dialysis-associated pruritus has been linked to depression, lower quality of life, disordered sleep, and increased mortality (2-3). In addition to ensuring that patients are receiving adequate dialysis, the treatment of dialysis-associated pruritus is largely symptomatic. Available treatments including phototherapy, antihistamines, and gabapentin or related agents have dose-limiting side effects and limited efficacy for chronic pruritus (4).
      Citation: Kidney International (2019)
      PubDate: 2019-10-25
  • Does MRI trump pathology' An new era for staging and monitoring of
           kidney fibrosis
    • Authors: Anna Caroli; Andrea Remuzzi, Giuseppe Remuzzi
      Abstract: Renal fibrosis, which is characterised by the progressive deposition and accumulation of excess extracellular matrix (1), is a strong predictor of progression in chronic kidney disease (CKD)(2)(3). Recent advances in diagnostic imaging techniques, including ultrasonography and non contrast-enhanced magnetic resonance imaging (MRI), have shown promise for non-invasive assessment of renal fibrosis both in animals and humans.(4) However, the specificity of these techniques is controversial, as they indirectly assess renal fibrosis by evaluating the impact on mechanical or molecular properties of the tissue, and in the case of functional MRI, on kidney function.
      Citation: Kidney International (2019)
      PubDate: 2019-10-25
  • Whole exome sequencing identified ATP6V1C2 as a novel candidate gene for
           recessive distal renal tubular acidosis
    • Authors: Tilman Jobst-Schwan; Verena Klämbt, Maureen Tarsio, John F. Heneghan, Amar J. Majmundar, Shirlee Shril, Florian Buerger, Isabel Ottlewski, Boris E. Shmukler, Rezan Topaloglu, Seema Hashmi, Farkhanda Hafeez, Francesco Emma, Marcella Greco, Guido F. Laube, Hanan M. Fathy, Martin Pohl, Jutta Gellermann, Danko Milosevic, Michelle A. Baum, Shrikant Mane, Richard P. Lifton, Patricia M. Kane, Seth Alper, Friedhelm Hildebrandt
      Abstract: Distal renal tubular acidosis is a rare renal tubular disorder characterized by hyperchloremic metabolic acidosis and impaired urinary acidification. Mutations in three genes (ATP6V0A4, ATP6V1B1 and SLC4A1) constitute a monogenic causation in 58-70% of familial cases of distal renal tubular acidosis. Recently, mutations in FOXI1 have been identified as an additional cause. Therefore, we hypothesized that further monogenic causes of distal renal tubular acidosis remain to be discovered. Panel sequencing and/or whole exome sequencing was performed in a cohort of 17 families with 19 affected individuals with pediatric onset distal renal tubular acidosis.
      Citation: Kidney International (2019)
      PubDate: 2019-10-22
      DOI: 10.1016/j.kint.2019.09.026
  • Avian erythroblastosis virus E26 oncogene homolog-1 (ETS-1) plays a role
           in renal microvascular pathophysiology in the Dahl salt-sensitive rat
    • Authors: Wenguang Feng; Zhengrong Guan, Dongqi Xing, Xingsheng Li, Wei-zhong Ying, Colton E. Remedies, Edward W. Inscho, Paul W. Sanders
      Abstract: Prior studies reported that haploinsufficiency of the transcription factor ETS-1 is renoprotective in Dahl salt-sensitive rats, but the mechanism is unclear. Here, we tested whether ETS-1 is involved in hypertension-induced renal microvascular pathology and autoregulatory impairment. Hypertension was induced in salt-sensitive rats and salt-sensitive rats that are heterozygous with one wild-type or reference allele of Ets1 (SSEts1+/-) by feeding a diet containing 4% sodium chloride for one week. Increases in blood pressure did not differ.
      Citation: Kidney International (2019)
      PubDate: 2019-10-22
      DOI: 10.1016/j.kint.2019.09.025
  • Mast cell chymase protects against acute ischemic kidney injury by
           limiting neutrophil hyperactivation and recruitment
    • Authors: Lydia Celia Madjene; Luca Danelli, Albert Dahdah, Shamila Vibhushan, Julie Bex-Coudrat, Emeline Pacreau, Celine Vaugier, Julien Claver, Loïc Rolas, Maguelonne Pons, Iris Karina Madera-Salcedo, Walid Beghdadi, Alaa ElGhoneimi, Marc Benhamou, Pierre Launay, Magnus Abrink, Gunnar Pejler, Ivan Cruz Moura, Nicolas Charles, Eric Daugas, Axel Perianin, Ulrich Blank
      Abstract: Here we investigated the role of murine mast cell protease 4 (MCPT4), the functional counterpart of human mast cell chymase, in an experimental model of renal ischemia reperfusion injury, a major cause of acute kidney injury. MCPT4-deficient mice had worsened kidney function compared to wildtype mice. MCPT4 absence exacerbated pathologic neutrophil infiltration in the kidney and increased kidney myeloperoxidase expression, cell death and necrosis. In kidneys with ischemia reperfusion injury, when compared to wildtype mice, MCPT4-deficient mice showed increased surface expression of adhesion molecules necessary for leukocyte extravasation including neutrophil CD162 and endothelial cell CD54.
      Citation: Kidney International (2019)
      PubDate: 2019-10-10
      DOI: 10.1016/j.kint.2019.08.037
  • A collagen-binding protein enables molecular imaging of kidney fibrosis in
    • Authors: Maike Baues; Barbara M. Klinkhammer, Josef Ehling, Felix Gremse, Marc A.M. J. van Zandvoort, Chris P.M. Reutelingsperger, Christoph Daniel, Kerstin Amann, Janka Bábíčková, Fabian Kiessling, Jürgen Floege, Twan Lammers, Peter Boor
      Abstract: Pathological deposition of collagen is a hallmark of kidney fibrosis. To illustrate this process we employed multimodal optical imaging to visualize and quantify collagen deposition in murine models of kidney fibrosis (ischemia-reperfusion or unilateral ureteral obstruction) using the collagen-binding adhesion protein CNA35. For in vivo imaging, we used hybrid computed tomography-fluorescence molecular tomography and CNA35 labeled with the near-infrared fluorophore Cy7. Upon intravenous injection, CNA35-Cy7 accumulation was significantly higher in fibrotic compared to non-fibrotic kidneys.
      Citation: Kidney International (2019)
      PubDate: 2019-09-18
      DOI: 10.1016/j.kint.2019.08.029
  • Class Effect: Dapagliflozin Reduces Cardiovascular and Kidney Events
    • Authors: Tania Salehi; P. Toby Coates
      First page: 246
      Abstract: The sodium-dependent glucose co-transporter (SGLT-2) inhibitors are the newest class of oral agents in the armoury of the physician to combat type 2 diabetes mellitus (T2DM). The significant reduction in cardiovascular outcomes with all three SGLT2- inhibitors is now well documented (1-3), as is the reduction in chronic kidney disease (CKD) outcomes with canagliflozin (4). The effect of another SGLT-2 inhibitor, dapagliflozin, on long term CKD outcomes is the subject of a secondary analysis of the Dapagliflozin Effect on Cardiovascular Events–Thrombolysis In Myocardial Infarction 58 (DECLARE-TIMI 58) trial, recently published in Lancet Diabetes and Endocrinology (5).
      Citation: Kidney International (2019)
      PubDate: 2019-10-10
      DOI: 10.1016/j.kint.2019.08.035
  • Immunotherapy to delay the clinical onset of type 1 diabetes
    • Authors: Mai Sugahara; Tetsuhiro Tanaka, Masaomi Nangaku
      First page: 248
      Abstract: Type 1 diabetes is an autoimmune disease characterized by loss of pancreatic beta cells and reliance on exogenous insulin for survival. It is one of the most common chronic diseases of childhood, and its incidence is increasing worldwide.1 Despite significant advances in insulin therapy, many patients fail to achieve satisfactory glycemic control, which leads to an increased risk of complications and reduced life expectancy.2
      Citation: Kidney International (2019)
      PubDate: 2019-10-25
  • Prevention and treatment of stroke in patients with chronic kidney
           disease: an overview of evidence and current guidelines
    • Authors: Dearbhla M. Kelly; Peter M. Rothwell
      First page: 266
      Abstract: Chronic Kidney Disease (CKD) is strongly associated with an increased risk of stroke, small vessel disease, and vascular dementia. Common vascular factors for stroke, such as hypertension, diabetes, and atrial fibrillation, are more prevalent in CKD patients, accounting for this association. However, factors unique to these patients, such as uraemia, oxidative stress, mineral and bone abnormalities, as well as dialysis-related factors are also believed to contribute to risk. Despite improvements in stroke treatment and survival in the general population, the rate of improvement in patients with CKD, especially those who are dialysis-dependent, has lagged behind.
      Citation: Kidney International (2019)
      PubDate: 2019-10-18
      DOI: 10.1016/j.kint.2019.09.024
  • Apolipoprotein E-related glomerular disorders
    • Authors: Takao Saito; Akira Matsunaga, Megumu Fukunaga, Kiyotaka Nagahama, Shigeo Hara, Eri Muso
      First page: 279
      Abstract: Of the glomerular disorders that occur due to apolipoprotein E (apoE) mutations, apoE2 homozygote glomerulopathy and lipoprotein glomerulopathy (LPG) have been identified. ApoE2 homozygote glomerulopathy was found in individuals expressing homozygous apoE2/2. This was characterized histologically by glomerulosclerosis with marked infiltration of foam cells derived from macrophages and, occasionally, with non-lamellated lipoprotein thrombi. Recently, several cases of apoE Toyonaka (Ser197Cys) combined with homozygous apoE2/2 have been reported, where non-immune membranous nephropathy-like features observed in glomeruli.
      Citation: Kidney International (2019)
      PubDate: 2019-11-22
  • The YB-1:Notch-3 axis modulates immune cell responses and organ damage in
           systemic lupus erythematosus
    • Authors: Daniel M. Breitkopf; Vera Jankowski, Kim Ohl, Juliane Hermann, Daniela Hermert, Klaus Tenbrock, Xiyang Liu, Ina V. Martin, Jialin Wang, Fabian Groll, Elisabeth Gröne, Jürgen Floege, Tammo Ostendorf, Thomas Rauen, Ute Raffetseder
      First page: 289
      Abstract: Systemic lupus erythematosus (SLE) is an autoimmune disease and lupus nephritis bares is a major risk for morbidity and mortality. Notch-3 signaling induced by membrane-bound or soluble ligands such as YB-1 constitutes an evolutionary conserved pathway that determines major decisions in cell fate. Mass spectrometry of extracellular YB-1 in sera from patients with SLE and lupus-prone mice revealed specific post-translational guanidinylation of two lysine residues within the highly conserved cold-shock domain of YB-1 (YB-1-G).
      Citation: Kidney International (2019)
      PubDate: 2019-10-29
      DOI: 10.1016/j.kint.2019.09.031
  • Defective bicarbonate reabsorption in Kir4.2 potassium channel deficient
           mice impairs acid-base balance and ammonia excretion
    • Authors: Yohan Bignon; Laurent Pinelli, Nadia Frachon, Olivier Lahuna, Lucile Figueres, Pascal Houillier, Stéphane Lourdel, Jacques Teulon, Marc Paulais
      First page: 304
      Abstract: The kidneys excrete the daily acid load mainly by generating and excreting ammonia but the underlying molecular mechanisms are not fully understood. Here we evaluated the role of the inwardly rectifying potassium channel subunit Kir4.2 (Kcnj15 gene product) in this process. In mice, Kir4.2 was present exclusively at the basolateral membrane of proximal tubular cells and disruption of Kcnj15 caused a hyperchloremic metabolic acidosis associated with a reduced threshold for bicarbonate in the absence of a generalized proximal tubule dysfunction.
      Citation: Kidney International (2019)
      PubDate: 2019-10-24
      DOI: 10.1016/j.kint.2019.09.028
  • Insulin promotes sodium transport but suppresses gluconeogenesis via
           distinct cellular pathways in human and rat renal proximal tubules.
    • Authors: Motonobu Nakamura; Hiroyuki Tsukada, George Seki, Nobuhiko Satoh, Tomohito Mizuno, Wataru Fujii, Shoko Horita, Kyoji Moriya, Yusuke Sato, Haruki Kume, Masaomi Nangaku, Masashi Suzuki
      First page: 316
      Abstract: Insulin is known to promote sodium transport and regulate gluconeogenesis in renal proximal tubules. Although protein kinase B (also known as Akt) and mammalian target of rapamycin complexes (mTORC) have been established as key regulators in the insulin signaling pathway, their roles in proximal tubules are poorly understood. To help define this, we examined the components of insulin signaling in sodium transport and gluconeogenesis in isolated human and rat proximal tubules, and also investigated the role of insulin in sodium handling and mTORC1 in insulin signaling in vivo.
      Citation: Kidney International (2019)
      PubDate: 2019-09-05
      DOI: 10.1016/j.kint.2019.08.021
  • Proximal tubule cyclophilin D regulates fatty acid oxidation in
           cisplatin-induced acute kidney injury
    • Authors: Hee-Seong Jang; Mi Ra Noh, Eui-Man Jung, Woo-Yang Kim, Chittibabu Guda, Kirk W. Foster, David Oupicky, Fernando A. Ferrer, Babu J. Padanilam
      First page: 327
      Abstract: Regardless of the etiology, acute kidney injury involves aspects of mitochondrial dysfunction and ATP depletion. Fatty acid oxidation is the preferred energy source of the kidney and is inhibited during acute kidney injury. A pivotal role for the mitochondrial matrix protein, cyclophilin D in regulating overall cell metabolism is being unraveled. We hypothesize that mitochondrial interaction of proximal tubule cyclophilin D and the transcription factor PPARα modulate fatty acid beta-oxidation in cisplatin-induced acute kidney injury.
      Citation: Kidney International (2019)
      PubDate: 2019-09-03
      DOI: 10.1016/j.kint.2019.08.019
  • TLR9 activation induces aberrant IgA glycosylation via APRIL- and
           IL-6-mediated pathways in IgA nephropathy
    • Authors: Yuko Makita; Hitoshi Suzuki, Toshiki Kano, Akiko Takahata, Bruce A. Julian, Jan Novak, Yusuke Suzuki
      First page: 340
      Abstract: Galactose-deficient IgA1 (Gd-IgA1) plays a crucial role in the development of IgA nephropathy (IgAN). However, the pathogenic mechanisms driving Gd-IgA1 production have not been fully elucidated. Innate-immune activation via Toll-like receptor 9 (TLR9) is known to be involved in Gd-IgA1 production. A proliferation inducing ligand (APRIL) and IL-6 are also known to enhance Gd-IgA1 synthesis in IgAN. With this as background, we investigated how TLR9 activation in IgA secreting cells results in overproduction of nephritogenic IgA in the IgAN-prone ddY mouse and in human IgA1-secreting cells.
      Citation: Kidney International (2019)
      PubDate: 2019-09-05
      DOI: 10.1016/j.kint.2019.08.022
  • Chronic interstitial nephritis in agricultural communities is a toxin
           induced proximal tubular nephropathy
    • Authors: Benjamin A. Vervaet; Cynthia C. Nast, Channa Jayasumana, Gerd Schreurs, Frank Roels, Chula Herath, Nika Kojc, Vahid Samaee, Sonali Rodrigo, Swarnalata Gowrishankar, Christiane Mousson, Rajeewa Dassanayake, Carlos M. Orantes, Vincent Vuiblet, Claire Rigothier, Patrick C. D’Haese, Marc E. De Broe
      First page: 350
      Abstract: Almost 30 years after the detection of chronic interstitial nephritis in agricultural communities (CINAC) its etiology remains unknown. To help define this we examined 34 renal biopsies from Sri Lanka, El Salvador, India and France of patients with chronic kidney disease 2-3 and diagnosed with CINAC by light and electron microscopy. In addition to known histopathology, we identified a unique constellation of proximal tubular cell findings including large dysmorphic lysosomes with a light-medium electron-dense matrix containing dispersed dark electron-dense non-membrane bound “aggregates”.
      Citation: Kidney International (2019)
      PubDate: 2019-11-22
      DOI: 10.1016/j.kint.2019.11.009
  • Detection and characterization of mosaicism in autosomal dominant
           polycystic kidney disease
    • Authors: Katharina Hopp; Emilie Cornec-Le Gall, Sarah R. Senum, Iris BAW. te Paske, Sonam Raj, Sravanthi Lavu, Saurabh Baheti, Marie E. Edwards, Charles D. Madsen, Christina M. Heyer, Albert CM. Ong, Kyongtae T. Bae, Richard Fatica, Theodore I. Steinman, Arlene B. Chapman, Berenice Gitomer, Ronald D. Perrone, Frederic F. Rahbari-Oskoui, Vicente E. Torres, the HALT Progression of Polycystic Kidney Disease Group, the ADPKD Modifier Study, Peter C. Harris
      First page: 370
      Abstract: Autosomal dominant polycystic kidney disease (ADPKD) is an inherited, progressive nephropathy accounting for 4-10% of end stage renal disease worldwide. PKD1 and PKD2 are the most common disease loci, but even accounting for other genetic causes, about 7% of families remain unresolved. Typically, these unsolved cases have relatively mild kidney disease and often have a negative family history. Mosaicism, due to de novo mutation in the early embryo, has rarely been identified by conventional genetic analysis of ADPKD families.
      Citation: Kidney International (2019)
      PubDate: 2019-10-09
      DOI: 10.1016/j.kint.2019.08.038
  • Natural language processing of electronic health records is superior to
           billing codes to identify symptom burden in hemodialysis patients
    • Authors: Lili Chan; Kelly Beers, Amy Yau, Kinsuk Chauhan, Aine Duffy, Kumardeep Chaudhary, Neha Debnath, Aparna Saha, Pattharawin Pattharanitima, Judy Cho, Peter Kotanko, Alex Federman, Steven Coca, Tielman Van Vleck, Girish N. Nadkarni
      First page: 383
      Abstract: Symptoms are common in patients on maintenance hemodialysis but identification is challenging. New informatics approaches including natural language processing (NLP) can be utilized to identify symptoms from narrative clinical documentation. Here we utilized NLP to identify seven patient symptoms from notes of maintenance hemodialysis patients of the BioMe Biobank and validated our findings using a separate cohort and the MIMIC-III database. NLP performance was compared for symptom detection with International Classification of Diseases (ICD)-9/10 codes and the performance of both methods were validated against manual chart review.
      Citation: Kidney International (2019)
      PubDate: 2019-11-08
  • Both the rituximab dose and maintenance immunosuppression in
           steroid-dependent/ frequently-relapsing nephrotic syndrome have important
           effects on outcomes
    • Authors: Eugene Yu-hin Chan; Hazel Webb, Ellen Yu, Gian Marco Ghiggeri, Markus J. Kemper, Alison Lap-tak Ma, Tomohiko Yamamura, Aditi Sinha, Arvind Bagga, Julien Hogan, Claire Dossier, Marina Vivarelli, Isaac Desheng Liu, Koichi Kamei, Kenji Ishikura, Priya Sharma, Kjell Tullus
      First page: 393
      Abstract: Rituximab is an effective treatment for steroid-dependent/ frequently-relapsing nephrotic syndrome (SDFRNS) in children. However, the optimal rituximab regimen remains unknown. To help determine this we conducted an international, multicenter retrospective study at 11 tertiary pediatric nephrology centers in Asia, Europe and North America of children 1-18 years of age with complicated SDFRNS receiving rituximab between 2005-2016 for 18 or more months follow-up. The effect of rituximab prescribed at three dosing levels: low (375mg/m2), medium (750mg/m2) and high (1125-1500mg/m2), with or without maintenance immunosuppression (defined as concurrent use of corticosteroids, mycophenolate motile or calcineurin inhibition at first relapse or for at least six months following the rituximab treatment) was examined.
      Citation: Kidney International (2019)
      PubDate: 2019-10-31
      DOI: 10.1016/j.kint.2019.09.033
  • Blood pressure modifies outcomes in patients with stage 3 to 5 chronic
           kidney disease
    • Authors: Heng-Pin Chiang; Yi-Wen Chiu, Jia-Jung Lee, Chi-Chih Hung, Shang-Jyh Hwang, Hung-Chun Chen
      First page: 402
      Abstract: Observational studies have demonstrated that low blood pressure is related to poor clinical outcomes in patients with chronic kidney disease (CKD). Subgroup analyses from the SPRINT trial showed that targeting systolic blood pressure under 120 mmHg is less beneficial for patients with CKD. Although malnutrition and inflammation are common in patients with advanced CKD, such patients are usually excluded from clinical trials. Therefore, we hypothesized that malnutrition-inflammation-cachexia syndrome could explain this J-shaped relationship.
      Citation: Kidney International (2019)
      PubDate: 2019-11-07
  • Multiparametric magnetic resonance imaging shows promising results to
           assess renal transplant dysfunction with fibrosis
    • Authors: Octavia Bane; Stefanie Hectors, Sonja Gordic, Paul Kennedy, Mathilde Wagner, Amanda Weiss, Rafael Khaim, Zhengzi Yi, Weijia Zhang, Veronica Delaney, Fadi Salem, Cijiang He, Madhav C. Menon, Sara Lewis, Bachir Taouli
      First page: 414
      Abstract: Here we assessed the diagnostic value of a quantitative multiparametric magnetic resonance imaging (mpMRI) protocol for evaluation of renal allograft dysfunction with fibrosis. Twenty-seven renal transplant patients, including 15 with stable functional allografts (eGFR mean 71.5 ml/min/1.73m2), and 12 with chronic dysfunction/established fibrosis (eGFR mean 30.1 ml/min/1.73m2) were enrolled in this prospective single-center study. Sixteen of the patients had renal biopsy (mean 150 days) before the MRI.
      Citation: Kidney International (2019)
      PubDate: 2019-10-29
      DOI: 10.1016/j.kint.2019.09.030
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