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  Subjects -> MEDICAL SCIENCES (Total: 7101 journals)
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GASTROENTEROLOGY AND HEPATOLOGY (158 journals)                     

Showing 1 - 0 of 0 Journals sorted alphabetically
Abdominal Imaging     Hybrid Journal   (Followers: 15)
Acta Endoscopica     Hybrid Journal   (Followers: 1)
Acta Gastroenterologica Latinoamericana     Open Access   (Followers: 3)
Actualités Odonto-Stomatologiques     Open Access   (Followers: 4)
Advances in Diabetes and Metabolism     Open Access   (Followers: 9)
Advances in Digestive Medicine     Open Access   (Followers: 3)
AJP Gastrointestinal and Liver Physiology     Full-text available via subscription   (Followers: 6)
Akademik Gastroenteroloji Dergisi     Open Access  
Alimentary Pharmacology & Therapeutics     Hybrid Journal   (Followers: 32)
Alimentary Pharmacology & Therapeutics Symposium Series     Hybrid Journal   (Followers: 3)
American Journal of Gastroenterology Supplements     Full-text available via subscription   (Followers: 7)
American Journal of Gastroenterology, The     Hybrid Journal   (Followers: 98)
Arab Journal of Gastroenterology     Full-text available via subscription   (Followers: 3)
Arquivos de Gastroenterologia     Open Access   (Followers: 1)
Australian and New Zealand Continence Journal     Full-text available via subscription   (Followers: 3)
Avances en Odontoestomatologia     Open Access   (Followers: 1)
Best Practice & Research Clinical Gastroenterology     Full-text available via subscription   (Followers: 7)
BMC Gastroenterology     Open Access   (Followers: 13)
BMJ Open Diabetes Research & Care     Open Access   (Followers: 16)
BMJ Open Gastroenterology     Open Access   (Followers: 3)
Canadian Journal of Gastroenterology & Hepatology     Open Access   (Followers: 3)
Case Reports in Gastroenterology     Open Access   (Followers: 5)
Case Reports in Gastrointestinal Medicine     Open Access   (Followers: 3)
Case Reports in Hepatology     Open Access   (Followers: 1)
Cellular and Molecular Gastroenterology and Hepatology     Open Access   (Followers: 3)
Clinical and Experimental Gastroenterology     Open Access   (Followers: 4)
Clinical and Molecular Hepatology     Open Access   (Followers: 2)
Clinical and Translational Gastroenterology     Open Access   (Followers: 3)
Clinical Diabetes     Full-text available via subscription   (Followers: 32)
Clinical Gastroenterology and Hepatology     Hybrid Journal   (Followers: 25)
Clinical Journal of Gastroenterology     Hybrid Journal   (Followers: 12)
Clinical Medicine Insights : Gastroenterology     Open Access   (Followers: 5)
Clinics and Research in Hepatology and Gastroenterology     Hybrid Journal   (Followers: 7)
Clinics in Liver Disease     Full-text available via subscription   (Followers: 8)
Colon & Rectum     Hybrid Journal   (Followers: 4)
coloproctology     Hybrid Journal   (Followers: 2)
Colorectal Disease     Hybrid Journal   (Followers: 10)
Current Bladder Dysfunction Reports     Hybrid Journal  
Current Colorectal Cancer Reports     Hybrid Journal   (Followers: 2)
Current Diabetes Reports     Hybrid Journal   (Followers: 26)
Current Gastroenterology Reports     Hybrid Journal   (Followers: 4)
Current Hepatitis Reports     Hybrid Journal   (Followers: 7)
Current Opinion in Gastroenterology     Hybrid Journal   (Followers: 10)
Current Treatment Options in Gastroenterology     Hybrid Journal   (Followers: 5)
Der Gastroenterologe     Hybrid Journal  
Diabetes     Full-text available via subscription   (Followers: 350)
Diabetes Spectrum     Full-text available via subscription   (Followers: 8)
Diagnostic and Therapeutic Endoscopy     Open Access  
Dialysis & Transplantation     Hybrid Journal   (Followers: 7)
Digestion     Full-text available via subscription   (Followers: 5)
Digestive and Liver Disease     Hybrid Journal   (Followers: 11)
Digestive and Liver Disease Supplements     Full-text available via subscription   (Followers: 5)
Digestive Diseases     Full-text available via subscription   (Followers: 20)
Digestive Diseases and Sciences     Hybrid Journal   (Followers: 5)
Digestive Endoscopy     Hybrid Journal   (Followers: 2)
Diseases of the Colon & Rectum     Full-text available via subscription   (Followers: 22)
Diseases of the Esophagus     Hybrid Journal   (Followers: 2)
Dysphagia     Hybrid Journal   (Followers: 102)
Endoscopia     Open Access  
Endoscopy     Hybrid Journal   (Followers: 6)
Endoscopy International Open     Open Access  
Endoskopie heute     Hybrid Journal   (Followers: 1)
Esophagus     Hybrid Journal  
European Journal of Gastroenterology & Hepatology     Hybrid Journal   (Followers: 17)
Evidence-Based Gastroenterology     Full-text available via subscription   (Followers: 5)
Expert Review of Gastroenterology and Hepatology     Full-text available via subscription   (Followers: 7)
Frontline Gastroenterology     Full-text available via subscription   (Followers: 3)
Gastric Cancer     Hybrid Journal   (Followers: 1)
Gastroenterologia Kliniczna. Postępy i Standardy     Open Access  
Gastroenterología y Hepatología     Full-text available via subscription  
Gastroenterología y Hepatología (English Edition)     Hybrid Journal  
Gastroenterología y Hepatología Continuada     Full-text available via subscription  
Gastroenterologie up2date     Hybrid Journal   (Followers: 2)
Gastroenterology     Hybrid Journal   (Followers: 117)
Gastroenterology and Hepatology from bed to bench     Open Access   (Followers: 5)
Gastroenterology Clinics of North America     Full-text available via subscription   (Followers: 8)
Gastroenterology Insights     Open Access   (Followers: 4)
Gastroenterology Report     Open Access   (Followers: 2)
Gastroenterology Research     Open Access   (Followers: 5)
Gastroenterology Research and Practice     Open Access   (Followers: 4)
Gastrointestinal Cancer : Targets and Therapy     Open Access   (Followers: 2)
Gastrointestinal Endoscopy     Hybrid Journal   (Followers: 20)
Gastrointestinal Endoscopy Clinics of North America     Full-text available via subscription   (Followers: 5)
Gastrointestinal Intervention     Full-text available via subscription  
GE Portuguese Journal of Gastroenterology     Open Access  
Gut     Full-text available via subscription   (Followers: 131)
Gut Microbes     Full-text available via subscription   (Followers: 8)
Gut Pathogens     Full-text available via subscription   (Followers: 5)
Hemodialysis International     Hybrid Journal   (Followers: 3)
Hepatic Medicine: Evidence and Research     Open Access   (Followers: 4)
Hepatitis B Annual     Open Access   (Followers: 3)
Hepatitis Monthly     Open Access   (Followers: 4)
Hepatitis Research and Treatment     Open Access   (Followers: 6)
Hepatology     Hybrid Journal   (Followers: 37)
Hepatology International     Hybrid Journal   (Followers: 5)
Hepatology Research     Hybrid Journal   (Followers: 12)
Hernia     Hybrid Journal   (Followers: 3)
HPB: The official journal of the International Hepato Pancreato Biliary Association     Hybrid Journal   (Followers: 2)
Indian Journal of Gastroenterology     Open Access   (Followers: 2)
Inflammatory Bowel Diseases     Hybrid Journal   (Followers: 40)
Info Diabetologie     Full-text available via subscription  
International Journal of Celiac Disease     Open Access   (Followers: 2)
International Journal of Colorectal Disease     Hybrid Journal   (Followers: 10)
International Journal of Hepatology     Open Access   (Followers: 3)
International Journal of Stomatological Research     Open Access  
Journal Africain d'Hépato-Gastroentérologie     Hybrid Journal   (Followers: 2)
Journal of Clinical Gastroenterology     Hybrid Journal   (Followers: 11)
Journal of Coloproctology     Open Access   (Followers: 1)
Journal of Crohn's and Colitis     Hybrid Journal   (Followers: 9)
Journal of Crohn's and Colitis Supplements     Full-text available via subscription   (Followers: 2)
Journal of Diabetes Research and Clinical Metabolism     Open Access   (Followers: 1)
Journal of Digestive Diseases     Hybrid Journal   (Followers: 3)
Journal of Digestive Endoscopy     Open Access   (Followers: 2)
Journal of Gastroenterology     Hybrid Journal   (Followers: 11)
Journal of Gastroenterology and Hepatology     Hybrid Journal   (Followers: 11)
Journal of Gastroenterology and Hepatology Research     Open Access   (Followers: 3)
Journal of Gastrointestinal Cancer     Hybrid Journal   (Followers: 3)
Journal of Gastrointestinal Oncology     Open Access   (Followers: 1)
Journal of Hepato-Biliary-Pancreatic Sciences     Hybrid Journal   (Followers: 3)
Journal of Hepatology     Hybrid Journal   (Followers: 17)
Journal of Obesity and Metabolic Research     Open Access  
Journal of Social Health and Diabetes     Open Access   (Followers: 1)
Journal of Viral Hepatitis     Hybrid Journal   (Followers: 8)
Kidney Disease and Transplantation     Open Access   (Followers: 1)
Kidney International Supplements     Partially Free   (Followers: 3)
Liver Cancer     Full-text available via subscription   (Followers: 1)
Liver International     Hybrid Journal   (Followers: 9)
Liver Transplantation     Hybrid Journal   (Followers: 8)
Methods in Enzymology     Full-text available via subscription   (Followers: 11)
Nature Reviews Gastroenterology & Hepatology     Full-text available via subscription   (Followers: 28)
Nederlands Tijdschrift voor Diabetologie     Hybrid Journal  
Neurogastroenterology & Motility     Hybrid Journal   (Followers: 2)
Nigerian Journal of Gastroenterology and Hepatology     Full-text available via subscription  
Obesity Science & Practice     Open Access  
Oncology, Gastroenterology and Hepatology Reports     Open Access   (Followers: 3)
Open Journal of Gastroenterology     Open Access   (Followers: 5)
Pancreatology     Full-text available via subscription   (Followers: 2)
Perspectives on Swallowing and Swallowing Disorders (Dysphagia)     Full-text available via subscription   (Followers: 19)
Revista Brasileira de Coloproctologia     Open Access  
Revista de Gastroenterología de México     Open Access  
Revista de Gastroenterología de México (English Edition)     Open Access  
Revista Española de Enfermedades Digestivas     Open Access   (Followers: 1)
Revue de Stomatologie et de Chirurgie Maxillo-faciale     Full-text available via subscription   (Followers: 1)
Saudi Journal of Gastroenterology     Open Access   (Followers: 3)
Saudi Journal of Obesity     Open Access  
Scandinavian Journal of Gastroenterology     Hybrid Journal   (Followers: 10)
Seminars in Liver Disease     Hybrid Journal   (Followers: 8)
South African Gastroenterology Review     Full-text available via subscription   (Followers: 1)
Techniques in Coloproctology     Hybrid Journal   (Followers: 9)
Techniques in Gastrointestinal Endoscopy     Hybrid Journal   (Followers: 2)
The Lancet Diabetes and Endocrinology     Full-text available via subscription   (Followers: 88)
Therapeutic Advances in Gastroenterology     Hybrid Journal   (Followers: 5)
United European Gastroenterology Journal     Hybrid Journal   (Followers: 2)
Visible Human Journal of Endoscopy     Full-text available via subscription  
Viszeralmedizin     Full-text available via subscription  
World Council of Enterostomal Therapists Journal     Full-text available via subscription  
World Journal of Gastroenterology     Full-text available via subscription   (Followers: 2)
Zeitschrift für Gastroenterologie     Hybrid Journal   (Followers: 5)

           

Journal Cover Gastroenterology Clinics of North America
  [SJR: 1.238]   [H-I: 68]   [8 followers]  Follow
    
   Full-text available via subscription Subscription journal  (Not entitled to full-text)
   ISSN (Print) 0889-8553
   Published by Elsevier Homepage  [3040 journals]
  • Basic Definitions and Concepts: Organization of the Gut Microbiome
    • Abstract: Publication date: Available online 3 January 2017
      Source:Gastroenterology Clinics of North America
      Author(s): Eamonn M.M. Quigley
      Teaser New claims are frequently made for a role for the microbiome in a disease or disorder previously considered remote from the gut. The microbiome has been linked to such seemingly unrelated entities as depression, anorexia nervosa, autism, Parkinson disease, allergy, and asthma. Although many of these proposals have been based on animal studies, explorations of the microbiome in human disease continue to proliferate, facilitated by technologies that provide a detailed assessment of the microbial inhabitants of our gastrointestinal tract and their biological activities and metabolic products. With these technologies come new terminologies, which are identified in this article.

      PubDate: 2017-01-08T03:26:23Z
       
  • Biology of the Microbiome
    • Abstract: Publication date: Available online 3 January 2017
      Source:Gastroenterology Clinics of North America
      Author(s): Sylwia Smolinska, David Groeger, Liam O’Mahony
      Teaser The intestinal immune system is intimately connected with the vast diversity of microbes present within the gut and the diversity of food components that are consumed daily. The discovery of novel molecular mechanisms, which mediate host-microbe-nutrient communication, have highlighted the important roles played by microbes and dietary factors in influencing mucosal immune responses. Dendritic cells, epithelial cells, innate lymphoid cells, T regulatory cells, effector lymphocytes, natural killer T cells, and B cells can all be influenced by the microbiome. Many of the mechanisms being described are bacterial strain or metabolite specific.

      PubDate: 2017-01-08T03:26:23Z
       
  • The Microbiome-Gut-Brain Axis in Health and Disease
    • Abstract: Publication date: Available online 4 January 2017
      Source:Gastroenterology Clinics of North America
      Author(s): Timothy G. Dinan, John F. Cryan
      Teaser Gut microbes are capable of producing most neurotransmitters found in the human brain. Evidence is accumulating to support the view that gut microbes influence central neurochemistry and behavior. Irritable bowel syndrome is regarded as the prototypic disorder of the brain-gut-microbiota axis that can be responsive to probiotic therapy. Translational studies indicate that certain bacteria may have an impact on stress responses and cognitive functioning. Manipulating the gut microbiota with psychobiotics, prebiotics, or even antibiotics offers a novel approach to altering brain function and treating gut-brain axis disorders, such as depression and autism.

      PubDate: 2017-01-08T03:26:23Z
       
  • The Gut Microbiota in Inflammatory Bowel Disease
    • Abstract: Publication date: Available online 4 January 2017
      Source:Gastroenterology Clinics of North America
      Author(s): Donal Sheehan, Fergus Shanahan
      Teaser Genes, bacteria, and immunity contribute to the pathogenesis of inflammatory bowel disease. Most genetic risk relates to defective sensing of microbes and their metabolites or defective regulation of the host response to the microbiota. Because the composition of the microbiota shapes the developing immune system and is determined in early life, the prospect of therapeutic manipulation of the microbiota in adulthood after the onset of disease is questionable. However, the microbiota may be a marker of risk and a modifier of disease activity and a contributor to extraintestinal manifestations and associations in some patients with inflammatory bowel disease.

      PubDate: 2017-01-08T03:26:23Z
       
  • Diet and the Microbiome
    • Abstract: Publication date: Available online 4 January 2017
      Source:Gastroenterology Clinics of North America
      Author(s): Nida Murtaza, Páraic Ó Cuív, Mark Morrison
      Teaser The gut microbiota provides a range of ecologic, metabolic, and immunomodulatory functions relevant to health and well-being. The gut microbiota not only responds quickly to changes in diet, but this dynamic equilibrium may be managed to prevent and/or treat acute and chronic diseases. This article provides a working definition of the term “microbiome” and uses two examples of dietary interventions for the treatment of large bowel conditions to emphasize the links between diet and microbiome. There remains a need to develop a better functional understanding of the microbiota, if its management for clinical utility is to be fully realized.

      PubDate: 2017-01-08T03:26:23Z
       
  • Biology of the Microbiome 2
    • Abstract: Publication date: Available online 4 January 2017
      Source:Gastroenterology Clinics of North America
      Author(s): Jia V. Li, Jonathan Swann, Julian R. Marchesi
      Teaser The human microbiome is a new frontier in biology and one that is helping to define what it is to be human. Recently, we have begun to understand that the “communication” between the host and its microbiome is via a metabolic superhighway. By interrogating and understanding the molecules involved we may start to know who the main players are, and how we can modulate them and the mechanisms of health and disease.

      PubDate: 2017-01-08T03:26:23Z
       
  • Gastrointestinal Neoplasia
    • Authors: Paul J. Limburg; Dan A. Dixon
      Abstract: Publication date: September 2016
      Source:Gastroenterology Clinics of North America, Volume 45, Issue 3
      Author(s): Paul J. Limburg, Dan A. Dixon


      PubDate: 2016-08-23T05:13:55Z
      DOI: 10.1016/s0889-8553(16)30049-8
       
  • Gastrointestinal Neoplasia: Current Perspectives and Emerging Frontiers
    • Authors: Paul J. Limburg; Dan A. Dixon
      Abstract: Publication date: September 2016
      Source:Gastroenterology Clinics of North America, Volume 45, Issue 3
      Author(s): Paul J. Limburg, Dan A. Dixon


      PubDate: 2016-08-23T05:13:55Z
      DOI: 10.1016/j.gtc.2016.06.001
       
  • Esophageal Cancer
    • Authors: Benjamin R. Alsop; Prateek Sharma
      Pages: 399 - 412
      Abstract: Publication date: September 2016
      Source:Gastroenterology Clinics of North America, Volume 45, Issue 3
      Author(s): Benjamin R. Alsop, Prateek Sharma
      Teaser Esophageal cancer carries a poor prognosis among gastrointestinal malignancies. Although esophageal squamous cell carcinoma predominates worldwide, Western nations have seen a marked rise in the incidence of esophageal adenocarcinoma that parallels the obesity epidemic. Efforts directed toward early detection have been difficult, given that dysplasia and early cancer are generally asymptomatic. However, significant advances have been made in the past 10 to 15 years that allow for endoscopic management and often cure in early stage esophageal malignancy. New diagnostic imaging technologies may provide a means by which cost-effective, early diagnosis of dysplasia allows for definitive therapy and ultimately improves the overall survival among patients.

      PubDate: 2016-08-23T05:13:55Z
      DOI: 10.1016/j.gtc.2016.04.001
       
  • Current Perspectives on Gastric Cancer
    • Authors: Juan M. Marqués-Lespier; María González-Pons; Marcia Cruz-Correa
      Pages: 413 - 428
      Abstract: Publication date: September 2016
      Source:Gastroenterology Clinics of North America, Volume 45, Issue 3
      Author(s): Juan M. Marqués-Lespier, María González-Pons, Marcia Cruz-Correa
      Teaser Gastric cancer (GC) is third leading cause of cancer-related death. Only 28.3% of new GC cases survive more than 5 years. Although incidence has declined in the United States, an increase is estimated for 2016. Risk factors include sex (risk is higher in men), Helicobacter pylori infection, heredity, and lifestyle. GC is usually diagnosed between the ages of 60–80 years. Prognosis of GC is largely dependent on the tumor stage at diagnosis and classification as intestinal or diffuse type; diffuse-type GC has worse prognosis. Chemoprevention has been shown to decrease risk, but is currently not used clinically.

      PubDate: 2016-08-23T05:13:55Z
      DOI: 10.1016/j.gtc.2016.04.002
       
  • Pancreatic Cancer
    • Authors: Cinthya S. Yabar; Jordan M. Winter
      Pages: 429 - 445
      Abstract: Publication date: September 2016
      Source:Gastroenterology Clinics of North America, Volume 45, Issue 3
      Author(s): Cinthya S. Yabar, Jordan M. Winter
      Teaser Pancreatic cancer is now the third leading cause of cancer related deaths in the United States, yet advances in treatment options have been minimal over the past decade. In this review, we summarize the evaluation and treatments for this disease. We highlight molecular advances that hopefully will soon translate into improved outcomes.

      PubDate: 2016-08-23T05:13:55Z
      DOI: 10.1016/j.gtc.2016.04.003
       
  • Small Bowel Adenocarcinoma
    • Authors: Thomas Aparicio; Aziz Zaanan; Florence Mary; Pauline Afchain; Sylvain Manfredi; Thomas Ronald Jeffry Evans
      Pages: 447 - 457
      Abstract: Publication date: September 2016
      Source:Gastroenterology Clinics of North America, Volume 45, Issue 3
      Author(s): Thomas Aparicio, Aziz Zaanan, Florence Mary, Pauline Afchain, Sylvain Manfredi, Thomas Ronald Jeffry Evans
      Teaser Small bowel adenocarcinomas (SBAs) are rare tumors, but their incidence is increasing. The most common primary location is the duodenum. Even though SBAs are more often sporadic, some diseases are risk factors. Early diagnosis of small bowel adenocarcinoma remains difficult, despite significant radiologic and endoscopic progress. After R0 surgical resection, the main prognostic factor is lymph node invasion. An international randomized trial (BALLAD [Benefit of Adjuvant Chemotherapy For Small Bowel Adenocarcinoma] study) will evaluate the benefit of adjuvant chemotherapy. For metastatic disease, retrospectives studies suggest that platinum-based chemotherapy is the most effective treatment. Phase II studies are ongoing to evaluate targeted therapy in metastatic SBA.

      PubDate: 2016-08-23T05:13:55Z
      DOI: 10.1016/j.gtc.2016.04.004
       
  • Colorectal Cancer
    • Authors: Joshua C. Obuch; Dennis J. Ahnen
      Pages: 459 - 476
      Abstract: Publication date: September 2016
      Source:Gastroenterology Clinics of North America, Volume 45, Issue 3
      Author(s): Joshua C. Obuch, Dennis J. Ahnen
      Teaser Cancer is fundamentally a genetic disease caused by mutational or epigenetic alterations in DNA. There has been a remarkable expansion of the molecular understanding of colonic carcinogenesis in the last 30 years and that understanding is changing many aspects of colorectal cancer care. It is becoming increasingly clear that there are genetic subsets of colorectal cancer that have different risk factors, prognosis, and response to treatment. This article provides a general update on colorectal cancer and highlights the ways that genetics is changing clinical care.

      PubDate: 2016-08-23T05:13:55Z
      DOI: 10.1016/j.gtc.2016.04.005
       
  • Knowns and Known Unknowns of Gastrointestinal Stromal Tumor Adjuvant
           Therapy
    • Authors: Virginia Martínez-Marín; Robert G. Maki
      Pages: 477 - 486
      Abstract: Publication date: September 2016
      Source:Gastroenterology Clinics of North America, Volume 45, Issue 3
      Author(s): Virginia Martínez-Marín, Robert G. Maki
      Teaser The first 15 years of management of gastrointestinal stromal tumor (GIST) have led to 3 lines of therapy for metastatic disease: imatinib, sunitinib, and regorafenib. In the adjuvant setting, imatinib is usually given for 3 years postoperatively to patients with higher-risk primary tumors that are completely resected. In this review, issues regarding GIST adjuvant therapy are discussed. It is hoped this review will help the reader understand the present standard of care to improve upon it in years to come.

      PubDate: 2016-08-23T05:13:55Z
      DOI: 10.1016/j.gtc.2016.04.006
       
  • Neuroendocrine Tumors
    • Authors: Ron Basuroy; Raj Srirajaskanthan; John K. Ramage
      Pages: 487 - 507
      Abstract: Publication date: September 2016
      Source:Gastroenterology Clinics of North America, Volume 45, Issue 3
      Author(s): Ron Basuroy, Raj Srirajaskanthan, John K. Ramage
      Teaser Neuroendocrine tumors are increasingly diagnosed, either incidentally as part of screening processes, or for symptoms, which have commonly been mistaken for other disorders initially. The diagnostic workup to characterize tumor behaviour and prognosis focuses on histologic, anatomic, and functional imaging assessments. Several therapeutic options exist for patients ranging from curative and debulking surgery through to liver-directed therapies and systemic treatments. Multimodal therapies are often required over the patient’s disease history. The management paradigm can be complex but should be focused on curative resections and then on controlling symptoms and limiting disease progression. There are several new systemic therapies that have completed phase 3 studies with new compounds being studied in phase 2. Genetic and epigenetic markers may lead to a new era of personalised therapy in the future.

      PubDate: 2016-08-23T05:13:55Z
      DOI: 10.1016/j.gtc.2016.04.007
       
  • Heritable Gastrointestinal Cancer Syndromes
    • Authors: Elena M. Stoffel
      Pages: 509 - 527
      Abstract: Publication date: September 2016
      Source:Gastroenterology Clinics of North America, Volume 45, Issue 3
      Author(s): Elena M. Stoffel
      Teaser Although almost all gastrointestinal cancers develop from sporadic genomic events, approximately 5% arise from germline mutations in genes associated with cancer predisposition. The number of these genes continues to increase. Tumor phenotypes and family history provide the framework for identifying at-risk individuals. The diagnosis of a hereditary cancer syndrome has implications for management of patients and their families. Systematic approaches that integrate family history and molecular characterization of tumors and polyps facilitate identification of individuals with this genetic predisposition. This article summarizes diagnosis and management of hereditary cancer syndromes associated with gastrointestinal cancers.

      PubDate: 2016-08-23T05:13:55Z
      DOI: 10.1016/j.gtc.2016.04.008
       
  • Molecular Detection of Gastrointestinal Neoplasia
    • Authors: Bradley W. Anderson; David A. Ahlquist
      Pages: 529 - 542
      Abstract: Publication date: September 2016
      Source:Gastroenterology Clinics of North America, Volume 45, Issue 3
      Author(s): Bradley W. Anderson, David A. Ahlquist
      Teaser Emerging molecular tools promise to extend the diagnostic reach of the endoscopist and open doors to population screening for gastrointestinal (GI) cancers. This review briefly addresses biological considerations in marker detection and types of markers, highlights examples of tools under development at each organ site, and appraises the possibility of universal GI cancer screening. The outlook is positive, but further technical refinement and rigorous clinical validation are needed before most of these new approaches are ready for clinical application.

      PubDate: 2016-08-23T05:13:55Z
      DOI: 10.1016/j.gtc.2016.04.009
       
  • The Role of the Microbiome in Gastrointestinal Cancer
    • Authors: Lydia E. Wroblewski; Richard M. Peek; Lori A. Coburn
      Pages: 543 - 556
      Abstract: Publication date: September 2016
      Source:Gastroenterology Clinics of North America, Volume 45, Issue 3
      Author(s): Lydia E. Wroblewski, Richard M. Peek, Lori A. Coburn
      Teaser Humans are host to complex microbial communities previously termed normal flora and largely overlooked. However, resident microbes contribute to both health and disease. Investigators are beginning to define microbes that contribute to the development of gastrointestinal malignancies and the mechanisms by which this occurs. Resident microbes can induce inflammation, leading to cell proliferation and altered stem cell dynamics, which can lead to alterations in DNA integrity and immune regulation and promote carcinogenesis. Studies in human patients and rodent models of cancer have identified alterations in the microbiota of the stomach, esophagus, and colon that increase the risk for malignancy.

      PubDate: 2016-08-23T05:13:55Z
      DOI: 10.1016/j.gtc.2016.04.010
       
  • Women’s Health in Gastroenterology
    • Authors: Laurel R. Fisher
      Abstract: Publication date: June 2016
      Source:Gastroenterology Clinics of North America, Volume 45, Issue 2
      Author(s): Laurel R. Fisher


      PubDate: 2016-06-03T06:34:06Z
      DOI: 10.1016/s0889-8553(16)30024-3
       
  • Women’s Gastrointestinal Health in 2016: An Introduction to an Expanding
           Field in Gastroenterology
    • Authors: Laurel R. Fisher
      Abstract: Publication date: June 2016
      Source:Gastroenterology Clinics of North America, Volume 45, Issue 2
      Author(s): Laurel R. Fisher


      PubDate: 2016-06-03T06:34:06Z
      DOI: 10.1016/j.gtc.2016.03.001
       
  • Irritable Bowel Syndrome and Female Patients
    • Authors: Lucinda A. Harris; Sarah B. Umar; Noemi Baffy; Margaret M. Heitkemper
      Pages: 179 - 204
      Abstract: Publication date: June 2016
      Source:Gastroenterology Clinics of North America, Volume 45, Issue 2
      Author(s): Lucinda A. Harris, Sarah B. Umar, Noemi Baffy, Margaret M. Heitkemper
      Teaser Irritable bowel syndrome is probably the most common functional gastrointestinal disorder and is characterized by abdominal pain along with altered bowel function. It is a disorder of female predominance. This article focuses on how being female influences the pathophysiology, diagnosis, management, and treatment of this common disorder and discusses the evidence and important controversies related to these areas.

      PubDate: 2016-06-03T06:34:06Z
      DOI: 10.1016/j.gtc.2016.02.001
       
  • Chronic Constipation
    • Authors: Darren M. Brenner; Marmy Shah
      Pages: 205 - 216
      Abstract: Publication date: June 2016
      Source:Gastroenterology Clinics of North America, Volume 45, Issue 2
      Author(s): Darren M. Brenner, Marmy Shah
      Teaser Chronic constipation is a common disorder that affects approximately 20% of the population and significantly impacts an individual’s quality of life. The diagnosis can be made using standard criteria, and in the absence of alarm signs or symptoms, a determination of the underlying etiology/etiologies should be undertaken. In many instances, these will be gleaned from the history and physical examination. Specialized diagnostic testing may be warranted after the failure of initial laxative trials. Many therapeutic classes of laxatives exist with recent analyses indicating that practicing physicians prefer to use over-the-counter therapies in lieu of more strongly evidence-based prescription pharmaceuticals.

      PubDate: 2016-06-03T06:34:06Z
      DOI: 10.1016/j.gtc.2016.02.013
       
  • Childhood Overweight and Obesity
    • Abstract: Publication date: December 2016
      Source:Gastroenterology Clinics of North America, Volume 45, Issue 4
      Author(s): Jamilah Grant-Guimaraes, Ronald Feinstein, Erica Laber, Jennifer Kosoy
      Teaser Childhood overweight and obesity are increasing in prevalence and are a growing health concern. The diseases and their comorbidities have devastating consequences to children and adults as well as families, communities, and the nation. Comorbidities are cardiorespiratory, endocrinologic, gastrointestinal, orthopedic, and psychosocial. Health care providers are facing this crisis with limited medical, community, and federal resources and insufficient reimbursement. This article reviews recent trends in the assessment and treatment of this disease as well as trends in reimbursement, financial implications, and the need for further research and advocacy.

      PubDate: 2016-11-16T14:02:33Z
       
  • Obesity and Gastroenterology
    • Abstract: Publication date: December 2016
      Source:Gastroenterology Clinics of North America, Volume 45, Issue 4
      Author(s): Octavia Pickett-Blakely, Linda A. Lee


      PubDate: 2016-11-16T14:02:33Z
       
  • The Surgical Management of Obesity
    • Abstract: Publication date: December 2016
      Source:Gastroenterology Clinics of North America, Volume 45, Issue 4
      Author(s): Christopher J. Neylan, Umashankkar Kannan, Daniel T. Dempsey, Noel N. Williams, Kristoffel R. Dumon
      Teaser In the United States, more than one-third of the population is obese. Currently, bariatric surgery is the best known treatment for obesity, and multiple meta-analyses have shown bariatric surgery to be more effective for treating obesity than diet and exercise or pharmacologic treatment. The modern era of bariatric surgery began in 2005, which is defined by a drastic increase in the use of laparoscopy. Bariatric surgery has the potential to improve obesity-related comorbidities, such as type 2 diabetes, cardiovascular disease, and sleep apnea. The effect of bariatric surgery on weight loss and comorbidities varies by the type of procedure.

      PubDate: 2016-11-16T14:02:33Z
       
  • Pharmacotherapy in Treatment of Obesity
    • Abstract: Publication date: December 2016
      Source:Gastroenterology Clinics of North America, Volume 45, Issue 4
      Author(s): Jeanette N. Keith
      Teaser Common disease states in gastroenterology are more effectively treated in an obese patient when weight loss is incorporated into the treatment plan. Strategies that seek to achieve weight loss improve outcomes in the treatment of hepatitis C, non-alcoholic fatty liver disease, and colorectal cancer, as examples. Pharmacologic therapy is an important adjunctive intervention that improves both short-term and long-term outcomes in the management of obese patients. This article reviews currently available drug therapy with a focus on pharmacotherapy approved long-term weight management in non-diabetic obese individuals since 2012, encouraging the use of these tools in the practice of gastroenterology.

      PubDate: 2016-11-16T14:02:33Z
       
  • Endoscopic Management
    • Abstract: Publication date: December 2016
      Source:Gastroenterology Clinics of North America, Volume 45, Issue 4
      Author(s): Michael C. Bennett, Ricardo Badillo, Shelby Sullivan
      Teaser Endoscopic bariatric therapy consists of devices or procedures for primary weight loss or weight regain after Roux-en-Y gastric bypass that are placed or done endoscopically. In most cases, they result in less weight loss, but fewer complications than bariatric surgery; and more weight loss than lifestyle therapy or weight loss medications. These therapies are important advances to treat patients with obesity. This article focuses on therapies or devices with US Food and Drug Administration approval or those with current or planned US pivotal trials.

      PubDate: 2016-11-16T14:02:33Z
       
  • The Gut Microbiota
    • Abstract: Publication date: December 2016
      Source:Gastroenterology Clinics of North America, Volume 45, Issue 4
      Author(s): Kristina B. Martinez, Joseph F. Pierre, Eugene B. Chang
      Teaser Obesity is an emerging global epidemic with profound challenges to world health care economies and societies. Traditional approaches to fighting obesity have not shown promise in promoting a decline in obesity prevalence. The gut microbiota is becoming widely appreciated for its role in regulating metabolism and thus represents a target for new therapies to combat obesity and associated comorbidities. This article provides an overview of altered microbial community structure in obesity, dietary impact on the gut microbiota, host-microbe interactions contributing to the disease, and improvements in microbial assemblage after bariatric surgery and with therapies targeting the gut microbiome.

      PubDate: 2016-11-16T14:02:33Z
       
  • Is Obesity Associated with Barrett’s Esophagus and Esophageal
           Adenocarcinoma?
    • Abstract: Publication date: December 2016
      Source:Gastroenterology Clinics of North America, Volume 45, Issue 4
      Author(s): Kristle Lee Lynch
      Teaser Barrett’s esophagus is a premalignant condition portending increased risk of esophageal adenocarcinoma. Given the significant morbidity and mortality of esophageal adenocarcinoma, identification of risk factors for Barrett’s esophagus and esophageal adenocarcinoma is crucial. There are a plethora of studies investigating the relationship of obesity with these pathologies. Recent studies reveal that this relationship may specifically be with central adiposity. Increased cell turnover and eventual carcinogenesis is likely precipitated by increased intragastric pressure but also is affected by the complex interplay of increased insulin resistance in patients with increased fat tissue. Further studies are warranted to evaluate if weight loss can decrease progression of Barrett’s esophagus.

      PubDate: 2016-11-16T14:02:33Z
       
  • Forthcoming Issues
    • Abstract: Publication date: December 2016
      Source:Gastroenterology Clinics of North America, Volume 45, Issue 4


      PubDate: 2016-11-16T14:02:33Z
       
  • Obesity and Gastroenterology
    • Abstract: Publication date: December 2016
      Source:Gastroenterology Clinics of North America, Volume 45, Issue 4
      Author(s): Octavia Pickett-Blakely, Linda A. Lee


      PubDate: 2016-11-16T14:02:33Z
       
  • Obesity Epidemiology Worldwide
    • Abstract: Publication date: December 2016
      Source:Gastroenterology Clinics of North America, Volume 45, Issue 4
      Author(s): Cassandra Arroyo-Johnson, Krista D. Mincey
      Teaser Obesity continues to be a public health concern across the globe. Obesity has a demonstrated association with health behaviors and health outcomes, such as diabetes, hypertension, and cancer. Over the past 2 decades, obesity has increased worldwide and remains highest in the United States. It is critical to understand the definition of obesity, using body mass index appropriately, recent estimates, and risk factors as a framework within which clinicians should work to help reduce the burden of obesity. This framework, including the Healthy People 2020 place-based approach to social determinants of health, is described in this article.

      PubDate: 2016-11-16T14:02:33Z
       
  • Future Therapies in Obesity
    • Abstract: Publication date: Available online 13 October 2016
      Source:Gastroenterology Clinics of North America
      Author(s): Octavia Pickett-Blakely, Carolyn Newberry
      Teaser Although diet and exercise have been the cornerstone of therapy for obesity, efficacy is suboptimal and short lived. Surgical procedures are durable but invasive therapy for obesity. Supplemental therapies for obesity that are minimally invasive, low risk, and effective are needed. Several therapeutic options are being developed that offer obese patients and their health care providers alternatives to what is currently available.

      PubDate: 2016-10-16T07:30:06Z
       
  • Physiologic and Neural Controls of Eating
    • Abstract: Publication date: Available online 13 October 2016
      Source:Gastroenterology Clinics of North America
      Author(s): Timothy H. Moran, Ellen E. Ladenheim
      Teaser Multiple physiologic and neural systems contribute to the controls over what and how much we eat. These systems include signaling involved in the detection and signaling of nutrient availability, signals arising from consumed nutrients that provide feedback information during a meal to induce satiation, and signals related to the rewarding properties of eating. Each of these has a separate neural representation, but important interactions among these systems are critical to the overall controls of food intake.

      PubDate: 2016-10-16T07:30:06Z
       
  • Nonalcoholic Fatty Liver Disease
    • Abstract: Publication date: Available online 13 October 2016
      Source:Gastroenterology Clinics of North America
      Author(s): Rotonya M. Carr, Amanke Oranu, Vandana Khungar
      Teaser Nonalcoholic fatty liver disease (NAFLD) is an important cause of morbidity and mortality worldwide and is rapidly becoming the leading cause of end-stage liver disease and liver transplant. With a prevalence of 30% in the United States, it has reached epidemic proportions. The clinical syndrome of NAFLD spans from bland steatosis to steatohepatitis, which can progress to fibrosis and cirrhosis. The pathogenesis includes the roles of hormones, nutritional and intestinal dysbiosis, insulin resistance, lipotoxicity, hepatic inflammation, and genes. Noninvasive testing and liver biopsy indications are reviewed. Approved and investigational therapies for NAFLD and nonalcoholic steatohepatitis are outlined in this article.

      PubDate: 2016-10-16T07:30:06Z
       
  • The Impact of Obesity on Gallstone Disease, Acute Pancreatitis, and
           Pancreatic Cancer
    • Abstract: Publication date: Available online 13 October 2016
      Source:Gastroenterology Clinics of North America
      Author(s): Zobeida Cruz-Monserrate, Darwin L. Conwell, Somashekar G. Krishna
      Teaser Obesity is a well-recognized risk factor for gallstone formation and increases the risk for gallstone-related complications. Pancreatic diseases are impacted adversely by obesity. Although weight loss surgery increases the risk of gallstone disease, evidence suggests that bariatric surgery mitigates the obesity-associated adverse prognostication in acute pancreatitis. Obesity is also a significant risk factor for pancreatic cancer. Obesity is a global epidemic and is increasing worldwide and among all age groups. There is an urgent need for focused health policies aimed at reducing the incidence and prevalence of obesity. This article summarizes the current literature highlighting the association between obesity and the pathophysiology and outcome of gallstone disease, pancreatitis, and pancreatic cancer.

      PubDate: 2016-10-16T07:30:06Z
       
  • Dietary and Behavioral Approaches in the Management of Obesity
    • Authors: Kimberly Gudzune
      Abstract: Publication date: Available online 30 August 2016
      Source:Gastroenterology Clinics of North America
      Author(s): Kimberly Gudzune
      Teaser Given the prevalence of overweight and obesity and their associated health conditions, clinicians will be increasingly tasked with the responsibility of addressing overweight and obesity. This article reviews the 5As approach—assess, advise, agree, assist, arrange—and how clinicians can use the approach facilitate weight management discussions with their patients that met the recommendations provided in the 2013 adult weight management guidelines issued by the American Heart Association/American College of Cardiology/The Obesity Society.

      PubDate: 2016-08-31T07:22:27Z
      DOI: 10.1016/j.gtc.2016.07.004
       
  • Forthcoming Issues
    • Abstract: Publication date: September 2016
      Source:Gastroenterology Clinics of North America, Volume 45, Issue 3


      PubDate: 2016-08-23T05:13:55Z
       
  • Forthcoming Issues
    • Abstract: Publication date: June 2016
      Source:Gastroenterology Clinics of North America, Volume 45, Issue 2


      PubDate: 2016-06-03T06:34:06Z
       
 
 
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