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ANAESTHESIOLOGY (121 journals)                     

Showing 1 - 121 of 121 Journals sorted alphabetically
Acta Anaesthesiologica Scandinavica     Hybrid Journal   (Followers: 62)
Acta Anaesthesiologica Taiwanica     Open Access   (Followers: 6)
Acute Pain     Full-text available via subscription   (Followers: 15)
Advances in Anesthesia     Full-text available via subscription   (Followers: 31)
African Journal of Anaesthesia and Intensive Care     Full-text available via subscription   (Followers: 9)
Ain-Shams Journal of Anaesthesiology     Open Access   (Followers: 2)
Ain-Shams Journal of Anesthesiology     Open Access   (Followers: 1)
Ambulatory Anesthesia     Open Access   (Followers: 9)
Anaesthesia     Hybrid Journal   (Followers: 238)
Anaesthesia & Intensive Care Medicine     Full-text available via subscription   (Followers: 72)
Anaesthesia and Intensive Care     Full-text available via subscription   (Followers: 62)
Anaesthesia Critical Care & Pain Medicine     Full-text available via subscription   (Followers: 28)
Anaesthesia Reports     Hybrid Journal  
Anaesthesia, Pain & Intensive Care     Open Access  
Anaesthesiology Intensive Therapy     Open Access   (Followers: 9)
Analgesia & Resuscitation : Current Research     Hybrid Journal   (Followers: 6)
Anestesia Analgesia Reanimación     Open Access   (Followers: 1)
Anestesia en México     Open Access   (Followers: 1)
Anesthesia & Analgesia     Hybrid Journal   (Followers: 276)
Anesthesia : Essays and Researches     Open Access   (Followers: 10)
Anesthesia Progress     Hybrid Journal   (Followers: 6)
Anesthésie & Réanimation     Full-text available via subscription   (Followers: 2)
Anesthesiology     Hybrid Journal   (Followers: 232)
Anesthesiology and Pain Medicine     Open Access   (Followers: 23)
Anesthesiology Clinics     Full-text available via subscription   (Followers: 25)
Anesthesiology Research and Practice     Open Access   (Followers: 15)
Angewandte Schmerztherapie und Palliativmedizin     Hybrid Journal  
Annales Françaises d'Anesthésie et de Réanimation     Full-text available via subscription   (Followers: 4)
Annals of Cardiac Anaesthesia     Open Access   (Followers: 15)
BDJ Team     Open Access   (Followers: 1)
Best Practice & Research Clinical Anaesthesiology     Hybrid Journal   (Followers: 15)
BJA : British Journal of Anaesthesia     Hybrid Journal   (Followers: 243)
BJA Education     Hybrid Journal   (Followers: 70)
BMC Anesthesiology     Open Access   (Followers: 18)
BMJ Supportive & Palliative Care     Hybrid Journal   (Followers: 46)
Brazilian Journal of Anesthesiology     Open Access   (Followers: 5)
Brazilian Journal of Anesthesiology (Edicion en espanol)     Open Access  
Brazilian Journal of Anesthesiology (English edition)     Open Access   (Followers: 1)
Brazilian Journal of Pain (BrJP)     Open Access  
British Journal of Pain     Hybrid Journal   (Followers: 28)
Canadian Journal of Anesthesia/Journal canadien d'anesthésie     Hybrid Journal   (Followers: 48)
Case Reports in Anesthesiology     Open Access   (Followers: 11)
Clinical Journal of Pain     Hybrid Journal   (Followers: 19)
Colombian Journal of Anesthesiology : Revista Colombiana de Anestesiología     Hybrid Journal   (Followers: 1)
Current Anaesthesia & Critical Care     Full-text available via subscription   (Followers: 36)
Current Anesthesiology Reports     Hybrid Journal   (Followers: 4)
Current Opinion in Anaesthesiology     Hybrid Journal   (Followers: 61)
Current Pain and Headache Reports     Hybrid Journal   (Followers: 2)
Der Anaesthesist     Hybrid Journal   (Followers: 9)
Der Schmerz     Hybrid Journal   (Followers: 4)
Der Schmerzpatient     Hybrid Journal  
Douleur et Analgésie     Hybrid Journal  
Egyptian Journal of Anaesthesia     Open Access   (Followers: 2)
Egyptian Journal of Cardiothoracic Anesthesia     Open Access  
EMC - Anestesia-Reanimación     Hybrid Journal  
EMC - Anestesia-Rianimazione     Hybrid Journal  
EMC - Urgenze     Full-text available via subscription  
European Journal of Anaesthesiology     Hybrid Journal   (Followers: 30)
European Journal of Pain     Full-text available via subscription   (Followers: 27)
European Journal of Pain Supplements     Full-text available via subscription   (Followers: 5)
Global Journal of Anesthesiology     Open Access   (Followers: 2)
Headache The Journal of Head and Face Pain     Hybrid Journal   (Followers: 5)
Indian Journal of Anaesthesia     Open Access   (Followers: 7)
Indian Journal of Pain     Open Access   (Followers: 2)
Indian Journal of Palliative Care     Open Access   (Followers: 8)
International Anesthesiology Clinics     Hybrid Journal   (Followers: 9)
International Journal of Clinical Anesthesia and Research     Open Access  
Itch & Pain     Open Access   (Followers: 2)
JA Clinical Reports     Open Access  
Journal Club Schmerzmedizin     Hybrid Journal  
Journal of Anesthesia & Clinical Research     Open Access   (Followers: 10)
Journal of Anaesthesiology Clinical Pharmacology     Open Access   (Followers: 8)
Journal of Anesthesia     Hybrid Journal   (Followers: 13)
Journal of Anesthesia History     Full-text available via subscription   (Followers: 1)
Journal of Anesthesiology and Clinical Science     Open Access   (Followers: 1)
Journal of Cellular and Molecular Anesthesia     Open Access  
Journal of Clinical Anesthesia     Hybrid Journal   (Followers: 13)
Journal of Critical Care     Hybrid Journal   (Followers: 42)
Journal of Headache and Pain     Open Access   (Followers: 3)
Journal of Neuroanaesthesiology and Critical Care     Open Access   (Followers: 3)
Journal of Neurosurgical Anesthesiology     Hybrid Journal   (Followers: 8)
Journal of Obstetric Anaesthesia and Critical Care     Open Access   (Followers: 22)
Journal of Pain     Hybrid Journal   (Followers: 19)
Journal of Pain and Symptom Management     Hybrid Journal   (Followers: 45)
Journal of Pain Research     Open Access   (Followers: 10)
Journal of Palliative Care     Full-text available via subscription   (Followers: 20)
Journal of Society of Anesthesiologists of Nepal     Open Access   (Followers: 2)
Journal of the Bangladesh Society of Anaesthesiologists     Open Access  
Jurnal Anestesi Perioperatif     Open Access  
Jurnal Anestesiologi Indonesia     Open Access  
Karnataka Anaesthesia Journal     Open Access   (Followers: 2)
Le Praticien en Anesthésie Réanimation     Full-text available via subscription   (Followers: 2)
Local and Regional Anesthesia     Open Access   (Followers: 8)
Medical Gas Research     Open Access   (Followers: 3)
Medycyna Paliatywna w Praktyce     Open Access   (Followers: 1)
OA Anaesthetics     Open Access   (Followers: 3)
Open Anesthesia Journal     Open Access  
Open Journal of Anesthesiology     Open Access   (Followers: 10)
Pain     Hybrid Journal   (Followers: 61)
Pain Clinic     Hybrid Journal   (Followers: 1)
Pain Management     Hybrid Journal   (Followers: 18)
Pain Medicine     Hybrid Journal   (Followers: 13)
Pain Research and Management     Open Access   (Followers: 7)
Pain Research and Treatment     Open Access   (Followers: 2)
Pain Studies and Treatment     Open Access   (Followers: 2)
Research and Opinion in Anesthesia and Intensive Care     Open Access   (Followers: 3)
Revista Chilena de Anestesia     Open Access   (Followers: 1)
Revista Colombiana de Anestesiología     Open Access   (Followers: 1)
Revista Cubana de Anestesiología y Reanimación     Open Access   (Followers: 1)
Revista da Sociedade Portuguesa de Anestesiologia     Open Access  
Revista Española de Anestesiología y Reanimación     Hybrid Journal  
Revista Española de Anestesiología y Reanimación (English Edition)     Full-text available via subscription   (Followers: 2)
Romanian Journal of Anaesthesia and Intensive Care     Open Access   (Followers: 1)
Saudi Journal of Anaesthesia     Open Access   (Followers: 7)
Scandinavian Journal of Pain     Hybrid Journal   (Followers: 1)
Southern African Journal of Anaesthesia and Analgesia     Open Access   (Followers: 8)
Sri Lankan Journal of Anaesthesiology     Open Access   (Followers: 2)
Survey of Anesthesiology     Full-text available via subscription   (Followers: 12)
Techniques in Regional Anesthesia and Pain Management     Hybrid Journal   (Followers: 11)
Topics in Pain Management     Full-text available via subscription   (Followers: 2)
Trends in Anaesthesia and Critical Care     Full-text available via subscription   (Followers: 23)


Similar Journals
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OA Anaesthetics
Number of Followers: 3  

  This is an Open Access Journal Open Access journal
ISSN (Online) 2052-7853
Published by OA Publishing London Homepage  [39 journals]
  • Bispectral index (Bis) guided comparison of control of haemodynamic
           responses by fentanyl and butorphanol during tracheal intubation in

    • Abstract: Background:Laryngoscopy and intubation are required for almost all neurosurgical patients undergoing general anaesthesia, which often causes certain undesired haemodynamic changes which may culminate in poor surgical outcome. Fentanyl and Butorphanol are commonly used for suppression of these undesired haemodynamic changes.  Aims:Aim of the study was to compare haemodynamicresponses during intubation and extubation along with BIS changes using equianalgesic doses of butorphanol (30µg/kg) or fentanyl (2µg/kg) as a component of general anaesthesia for neurosurgical patients. Methods & material:This was prospective randomised control study.One hundred and ten patients belonging to American Society of Anaesthesiology (ASA) grade l and ll were randomly allocated into two groups, Fentanyl group (F) and Butorphanol group (B). All Pts. were monitored in terms of Heart rate, ECG (Electrocardiogram), Non-invasive blood pressure, End tidal CO2 (ETCO2), Bispectral index (40-60) and oxygen saturation during intubation, 1 min before intubation and at an interval of 1 min till five minutes post intubation. Results were analyzed statistically with SPSS 16.0 version using  unpaired t-test. P value< 0.05 was considered as significant. Power of the study was 80. Results & conclusion: This study revealed that both Fentanyl and Butorphanol attenuated haemodynamic response to tracheal intubation like Mean arterial pressure (MAP) and Heart rate (HR) but there was significant(P<0.05) rise of heart rate and mean blood pressure post-intubation in Butorphanol group than in Fentanyl group. Therefore Fentanyl is better option for control of haemodynamic responses during tracheal intubation than Butorphanol.
      PubDate: 04/09/2017 10:29:02 pm
  • Our anesthesia experience in a patient with Goldenhar-Gorlin syndrome.

    • Abstract: Childrens with congenital anomalies affecting the airway can pose a significant challenge for the anesthesia management. In Goldenhar-Gorlin syndrome, anomalies that may lead to difficulty in intubation  anomaly may occur.Difficult or impossible laryngoscopy has been described in Goldenhar syndrome patients.The aim of this case report  is to attract attention to this syndrome which fulfills many criteria for difficulty of intubation.
      PubDate: 04/09/2017 10:29:02 pm
  • Ultrasound guidance for central venous cannulation: The future is now.

    • Abstract: Central venous cannulation (CVC) is an invasive procedure commonly performed in the operation theatres, ICUs and in some wards and emergency departments. The two major aspects of CVC technique that concerns us the most will be discussed in this review, the usability of the ultrasound guidance compared to the landmark technique and the future directions regarding the training of the next generations with ultrasound guided CVC, both in adults and children. The aim is to clarify the extent of dependence on ultrasound for performing CVC.
      PubDate: 04/09/2017 10:29:02 pm
  • Reported complications associated with the use of GlideScope® video
           laryngoscope–How can they be prevented'

    • Abstract:   Introduction The use of the GlideScope® video laryngoscope has increased tremendously since its release in 2001. Compared to the Macintosh laryngoscope, its unique design allows an improved view of the glottis. During intubation, it decreases the need to anteriorly displace the lower jaw or manipulate the cervical spine. As a result, there is lesser sympathetic response to intubation and possibly fewer traumas to the dentition. Intubation may be performed on an awake patient more easily. The GlideScope® video laryngoscope plays a significant role in the management of routine and difficult airways. Unfortunately, the same unique design also requires the use of a stylet and introduces blind spots in the oropharynx during intubation. As a result of this drawback, cases of airway trauma have been reported. We have aimed to write a critical review discussing the complications and precautions associated with the use of the GlideScope® video laryngoscope. Conclusion The GlideScope® video laryngoscope is an improvement over the Macintosh laryngoscope as it reduces airway manipulation, but further research must be conducted in order to increase our understanding of the potential pitfalls associated with it and to develop strategies to avoid them.
      PubDate: 04/13/2014 10:15:02 pm
  • Lung protective ventilation strategies in routine anaesthetic practice:
           ready for prime time'

    • Abstract:   Introduction The use of high tidal volumes, defined as tidal volume >10 ml/kg, in mechanically ventilated patients, was promoted as the standard after demonstrating the increased incidence of atelectasis in patients in whom low volume ventilation was used in the 1960s. However, in the 1970s, animal experiments suggested that high tidal volume ventilation leads to ventilator-induced lung injury, and this phenomenon was later confirmed by clinical studies. Protective ventilation is a ventilation strategy where the patient's lungs are ventilated with a low tidal volume (in the range of 48 ml/kg of predicted body weight), in order to protect the lungs from ventilator-induced lung injury. The benefits of using lung-protective ventilation strategies in patients with acute respiratory distress syndrome have been widely established and recommended. There is increasing evidence to prove that even in patients without acute respiratory distress syndrome, the use of high tidal volumes can cause injury to the lungs. Our aim was to review past literature regarding the use of lung-protective ventilation strategies in patients mechanically ventilated in the operating theatre, for elective or emergency procedures. We focussed our critical review on the prevention of lung injury using a prophylactic lung-protective ventilation strategy during anaesthesia, whilst maintaining oxygenation with recruitment manoeuvres, and providing practical recommendations for everyday clinical practice. Conclusion The use of lung protective ventilation is recommended in majority of patients that are ventilated during surgery. Further investigation is necessary to assess how these research findings could be implemented in everyday clinical practice.
      PubDate: 04/13/2014 10:15:02 pm
  • Heparin-induced thrombocytopenia: a clinical and economic review.

    • Abstract:   Introduction Heparin-induced thrombocytopenia is a serious immune-mediated, drug adverse effect. Research over the last 20 years has vastly expanded knowledge, awareness and management of this condition. This review includes findings mostly from primary source clinical and economic literature from this time period to synthesise a concise summary. We have highlighted key points regarding the pathophysiology, epidemiology and presentation, diagnosis and management, as well as the economic impact of heparin-induced thrombocytopenia. It is established that heparin-induced thrombocytopenia is relatively uncommon overall, despite the widespread use of heparin. However, delayed recognition leads to significantly increased morbidity, mortality and disability. Treatment requires prolonged courses of expensive alternative anticoagulants. All of these impose substantial costs to patients, hospitals and society. The aim of this review was to assess the clinical and economic factors influencing heparin-induced thrombocytopenia. Conclusion Heparin-induced thrombocytopenia remains a significant clinical problem and is associated with morbidity, mortality and disability. Using heparin products can reduce (but not eliminate) the incidence of heparin-induced thrombocytopenia. Properly administered treatment with factor Xa inhibitors or direct thrombin inhibitors can significantly decrease the direst complications of this condition and mitigate its economic impact.
      PubDate: 04/13/2014 10:15:02 pm
  • Subcutaneous dissociative conscious sedation outside the operating
           theatre: prospective randomised double-blind study.

    • Abstract: Background:         Colonoscopy is among the common diagnostic and therapeutic gastrointestinal interventions which is routinely done out of the operating room. The painful nature of the procedure and patient anxiety resulting from gas insufflation propose using sedatives and analgesic during the procedure. The goal of this study is comparing the safety of different methods of conscious sedation in remote location anesthesia. Methods: Our prospective randomized double - blind study was conducted in 90 adult patients who were scheduled for elective colonoscopy.Patients were randomly assigned to one of three groups; subcutaneous ketamine in conjunction with opioid (sDCS), propofol in conjunction with opioid and midazolam in combination with opioids.Extra doses of opioids were administered on demand during the procedure. Heart rate, blood pressure and Spo2 were measured throughout the procedure. Adverse effects and recovery events were recorded. Results: All patients tolerated the colonoscopy well. Three study groups were comparable with regard to heart rate, BP, apnea and SPO2. Pain score and opioid consumption were significantly lower in sDCS group. Patient cooperation and endoscopiest satisfaction were significantly higher in sDCS group. Recovery time was comparable in three groups and all patients experienced an uneventful recovery. Conclusion: Subcutaneous dissociative conscious sedation as a recently reported method of conscious sedation provides more safety and more patient satisfaction in comparison to conventional methods. sDCS could be considered as a safe and efficient method of conscious sedation in remote location anesthesia.
      PubDate: 04/13/2014 10:15:02 pm
  • Beta-blockers and the thyrotoxic patient for thyroid and non-thyroid
           surgery: A clinical review.

    • Abstract: Thyrotoxic patients presenting for surgery should ideally be biochemically and clinically euthyroid. This is conventionally achieved through the use of anti-thyroid drugs, beta-blocker therapy and iodine. However, there are some circumstances where anti-thyroid drugs may not be a viable option. The implications of this scenario are not widely reported in the literature. This clinical review looks at the evidence on the safety of beta-blocker therapy without the use of anti-thyroid drugs in the preparation of the thyrotoxic patient for surgery. We also highlight key points in the pathophysiology of thyrotoxicosis and the management goals of these patients.
      PubDate: 04/13/2014 10:15:02 pm
  • The effectiveness of educational programmes in ventilator bundle
           implementation: A systematic review.

    • Abstract: Background:Ventilator-associated pneumonia (VAP) is the most frequent nosocomial infection encountered in critical care settings. Thus, severalpackages(ventilatorbundles, VBs)have been designed to help reduce or eliminate VAP,promote adherence to evidence-based guidelines and thusimprove clinical outcomes.The aim of this systematic review was to assess current literature regarding the effectiveness of educational programmes on theirimplementation. Methods:A comprehensive literature search strategy was formulated in association with an information specialist. We then reviewed studies published between 2003 and 2012 listed in seven multidisciplinary databases (Ovid MEDLINE®, the Cumulative Index to Nursing and Allied Health Literature, Cochrane Library, Scopus, Web of Science, Medic, and Academic Search Premier).The study selection and quality assessment were carried out by two researchers independently and objectively. Results:Six original studies were included in the final review. Educational programmes werelinked to significant improvements in the overall adherence to VBs and a significant decrease in adverse clinical outcomes such as the incidence of VAP, monthly use of sedatives, duration of mechanical ventilation and hospitalisationcosts. Conclusion:Education programmes about VBs can promote adherenceto evidence-based guidelines and thus reduce the incidence of VAP. However,theyare often inconsistently developed, implemented and evaluated. There are needs for both effective education programmes and a universal method for evaluating their outcome.
      PubDate: 04/13/2014 10:15:02 pm
  • General endotracheal anaesthesia for lower-segment caesarean section: a
           vanishing art'

    • Abstract: Objectives: To compare Indian scenario vs. western scenario about the use of general anesthesia (GA) in obstetric patients and to emphasize on the lack of resident experience in providing general anesthesia for caesarean delivery in Anesthesiology training programs in western countries  Methods:Data about cesarean sections, type of anesthesia used and resident training in this regard was collected retrospectively in JIPMER over a period of 1 year from April 2009- March 2010. This data was compared with the corresponding western data in published literature  Results:The cesarean section rate in our institute during 2009-10 was 15.95%. Regional anaesthesia is   the anaesthetic technique of choice until unless general anaesthesia is indicated as evidenced by the fact that 85% of caesareans were done under regional anaesthesia. Totally 393 cases were done under general anaesthesia. Average number of GA for cesarean section per final year anesthesia resident in our institute was 65 (range 50-80). A recent survey reported that, in the United States, the mean number of general anesthetics for caesarean delivery per graduating CA III resident is less than five, and 13% had never provided general anesthesia during caesarean delivery. Conclusion:General anesthesia is indicated in high risk parturients who are already in a compromised state. Providing general anesthesia to a high risk parturient is much more challenging and requires specialized training.  The risk to the mother and the fetus increases when general anesthesia is undertaken on emergency basis. Lack of training to deal with such situations can become a major contributing factor in maternal and fetal morbidity and mortality. 
      PubDate: 04/13/2014 10:15:02 pm
  • Role of percutaneous tracheostomy in emergent difficult airway conditions:
           An update.

    • Abstract: Percutaneous tracheostomy has replaced the surgical approach of airway establishment in many intensive care unit patients and mainly indicated for elective use. However, the role in emergency conditions has yet to be adopted by standard guidelines. Therefore in this article, we have reviewed the present role of PT in an emergency situation and illustrated it with the help of a short case report. A operated case of CVJ anomaly patient developed severe respiratory insufficiency; however, was successfully managed with percutaneous tracheostomy. Many reports have been highlighted the successful management of emergent difficult airway.  Our case also demonstrates the feasibility of percutaneous tracheostomy technique in patients who need emergency airway access. In conclusion, percutaneous tracheostomy, though, considered to be elective option for airway management, may be used safely in emergency situation; however requires appropriate training and skills.
      PubDate: 04/13/2014 10:15:02 pm
  • Postoperative analgesia with intraperitoneal ropivacaine with and without
           fentanyl after laparoscopic cholecystectomy: A randomized double-blind
           controlled trail.

    • Abstract: Surgical procedures have been improved to reduce trauma to the patient, morbidity, mortality and hospital stay, with consequent reduction in health care costs. Patients undergoing laparoscopic procedures do experience postoperative pain, especially in the upper and lower abdomen, back and shoulder region. Intraperitoneal injections of local anesthetic have been proposed to minimize postoperative pain after laparoscopic surgery. Therefore, this randomized, placebo-controlled study was conducted to compare the effectiveness of intraperitoneal ropivacaine with or without fentanyl for postoperative analgesia after laparoscopic surgery. Patients were randomized into three groups (n=50) using a computer generated table of random numbers. All surgeries were carried out under general anaesthesia and patients were instructed preoperatively about grading the intensity of pain in postoperative period as per VAS and VRS scales. The drug was injected intraperitoneally before the removal of trocar at the end of the surgery. VAS scores immediate post operatively were 44.00±19.16 vs 22.20±5.06 vs 23.20±8.67 (p< 0.001) and at 6th hour 35.40±9.52 vs 29.40±4.24vs27.80±5.0 (p<0.001). Similarly, VRS score (2.60±0.88 vs 1.96±0.74 vs 1.62±0.56) was significantly reduced immediate postoperatively in group 3. At 6th hour VRS scores was 2.32±0.79 vs 1.94±0.42 vs 1.80±0.49, shows significantly less pain in patients receiving ropivacaine with fentanyl. Total analgesic consumption was also significantly less in group 3 patients (p<0.001) in comparison to group 1 and group 2. In group 1 the total analgesic (diclofenac) consumption was 149±42 mg, in group 2 was 97±47 mg and in group 3 was 84±25 mg.
      PubDate: 04/13/2014 10:15:02 pm
  • Microglia provide unexplored avenues to attenuate cognitive decline
           following isoflurane exposure in susceptible young and elderly patients: A
           critical review of TREM2-DAP12 function and therapeutic potential.

    • Abstract: Background Microglia are the principle mediators of neuroinflammation, as defined by increased expression of pro-inflammatory cytokines such as TNF-a, IL-1b and IL-6. Two patient populations, young and aged, are at significant risk for behavioural and cognitive impairments after isoflurane exposure. Evidence indicates that neuroinflammation may be one of the causative events leading to neuronal and synaptic loss. Conclusions Isoflurane exposure affects the actin cytoskeleton in neurons and astrocytes, but cytoskeletal effects from isoflurane exposure have not been well studied in microglia. TREM2 expression, a known inflammatory and cytoskeletal regulating protein, is reduced in young and aged population leading to depression of microglia phagocytosis and increased inflammation. Therefore, modulation of upstream or downstream TREM2-mediated signalling may be a route to attenuate cognitive impairments in both populations.
      PubDate: 04/13/2014 10:15:02 pm
  • Liver transplantation: An adventure for the anaesthesiologist.

    • Abstract: Liver transplantation has become the treatment of choice for end-stage liver disease and some cases of acute liver failure. The procedure is extremely complex and requires excellent surgical technique and experienced anaesthesiologists. Patients undergoing liver transplantation have severe liver disease characterised by multisystem disorders that provide many anesthetic challenges. Due to this fact extensive preoperative assessment is required. A detailed monitoring of the patient and a careful therapeutic concept is necessary to meet the extraordinary conditions during this exciting adventure called liver transplantation.
      PubDate: 04/13/2014 10:15:02 pm
  • Postoperative unilateral mydriasis caused by pneumocephalus.

    • Abstract: We report a case of unilateral mydriasis followingmicrovascular decompression for hemifacial spasmcomplicated by pneumocephalus through the operative incision. We think thatpneumocephalus lead to brainstem shift and distorted the right oculomotor nerve. Unilateral mydriasis is alarming after neurosurgery and must be interpreted with caution.
      PubDate: 04/13/2014 10:15:02 pm
  • In silico, in vitro and in vivo methods to analyse drug permeation across
           the blood–brain barrier: A critical review.

    • Abstract: Introduction The existence of the blood-brain barrier (BBB) in the human body leads to the insufficiency in delivering therapeutic compounds into the brain for the effective treatment of various neurological disorders. In order to determine the possibility of such agents to penetrate through the BBB, different in silico, in vitro, and in vivo methods may be implemented. Some of them are often provided with unreliable results while others are not feasible in high-throughput screening environment. The goal of this review is to characterize the latest state-of-the-art methods that have been developed and used in the pharmaceutical research in the last few decades to assess the permeation of novel therapeutic entities across the BBB. We carried out a literature research and study selection by searching for published biomedical articles in the PubMed archive. Conclusion Overall, the combination of in silico, in vitro, and in vivo methods in the BBB research may lead to the discovery of promising drug compounds and more accurate information of brain uptake mechanisms.
      PubDate: 04/13/2014 10:15:02 pm
  • Anaesthesia for resection of phaeochromocytoma in a patient with
           myasthenia gravis: A case report.

    • Abstract: Myasthenia gravis is a disease affecting the nicotinic acetylcholine receptor of the post-synaptic membrane of the neuromuscular junction, causing muscle fatigue and weakness. Phaeochromocytoma is a neuroendocrine tumour of the medulla of the adrenal glands or extra-adrenal chromaffin tissue that secretes excessive amounts of catecholamines. We report a rare case of myasthenia gravis and phaeochromocytoma, two anaesthetically-challenging conditions co-existing in the same patient, and discuss the anaesthetic considerations and management during the surgical resection of phaeochromocytoma.
      PubDate: 04/13/2014 10:15:02 pm
  • Trauma-hemorrhage and dendritic cell functions: A critical review of
           splenic dendritic cell dysfunction following trauma-hemorrhage and
           therapeutic approach.

    • Abstract: Background Many studies demonstrated that trauma-hemorrhage induces marked alterations in various immune functions. The trauma-hemorrhage-induced immunosuppression is associated with an increased susceptibility to subsequent sepsis, organ failure and mortality. Previous studies demonstrated that trauma-hemorrhage induces immunosuppression in both innate immune system and adaptive immune system. Dendritic cell is the most potent antigen-presenting cell that initiates innate and adaptive immune response. Conclusions Trauma-hemorrhageimpairs splenic dendritic cell maturation. Suppressed TLR4 expression and MAPK activation contribute to the hyporesponsiveness of splenic dendritic cell following trauma-hemorrhage. 17b-estradiol produces immunoprotective effects on splenic dendritic cell following trauma-hemorrhage. The immunomodulatory properties of 17b-estradiol might be a potent therapeutic strategy for the treatment of depressed splenic dendritic cell functions following trauma-hemorrhage.
      PubDate: 04/13/2014 10:15:02 pm
  • Microcirculation in clinical practice.

    • Abstract: Hemodynamic monitoring is a cornerstone of care in high-risk surgery and critically ill patients. Therapies aimed at optimising haemodynamic targets by means of resuscitation protocols have been demonstrated to improve patient outcomes. Nonetheless, in some specific clinical conditions (e.g. sepsis), due to the loss of vascular tone auto-regulation, in spite of cardiac output and mean arterial pressure increase, cellular hypoxia and organ dysfunction  may persist. These clinical states are characterised by macrocirculation-microcirculation uncoupling, in which high mortality rates still persist even after macrocirculatory optimisation. Over the last few years, new technologies specifically designed to aid in microcirculatory monitoring have been introduced into the market. This review will deal with the most studied and used of these technologies, including videomicroscopic techniques, laser Doppler, and Near infrared Spectroscopy (NIRS). The main advantages and limitations of each instrument will be considered.
      PubDate: 04/13/2014 10:15:02 pm
  • Acupuncture analgesia: Is it verum or sham'

    • Abstract: There is increasing evidence that acupuncture is an effective therapeutic technique for some patients with painful conditions, but there is ongoing controversy as to whether this effect is primarily due to the mechanical or direct effects of acupuncture (verum) or non-specific factors, including placebo (sham). This paper explores some of the issues involved in differentiating these, including the difficulty in designing a true sham acupuncture technique for investigative purposes, the range of techniques employed in acupuncture, how points to be treated are selected and the role of placebo in acupuncture delivery. It is likely that placebo effects contribute to, or enhance, the therapeutic effects of acupuncture, but the exact mechanism by which verum acupuncture works has yet to be fully elucidated.
      PubDate: 04/13/2014 10:15:02 pm
  • Retrograde intubation: An old new technique.

    • Abstract: In the last decade a new boom of scientific articles about retrograde intubation have been published. Case reports, applications, technique variations and comparison with other techniques reintroduce the scientific discussion of the technique, its indications, contra-indications, complications and technical advances. Despite the complications and contraindications linked to retrograde intubation it’s the utility is incontestable in specific situations. Although the success rate of retrograde intubation is variable some authors affirm that in the hands of those who use the technique frequently, retrograde intubation appears to have a high success rate. We believe that training in retrograde intubation would definitely be an advance that could increase the success rate of the technique as well as decrease the complications associated with it. Recent developments are appearing to enhance the retrograde intubation technique such as the combination with laryngeal nerve block, fibreoptic bronchoscopy and ultrasound guidance. In times when advances in airway management technologies are booming, anesthesiologists should sometimes return to the basics and learn and practice simple techniques like retrograde intubation that can save patient lives.
      PubDate: 04/13/2014 10:15:02 pm
  • Comparison of haemodynamic, cerebral responses and auditory evoked
           potentials, bispectral index, electroencephalography with different doses
           of opioids in coronary artery bypass surgery.

    • Abstract: Fiftytwo ASAII-III patients undergoing elective coronary artery bypass surgery were included in the study. We examined the hemodynamic and cerebral responses to induction and intubation in cardiac surgery using different doses of opioid. Before induction(T1) values of systolic arterial pressure(SAP), mean arterial pressure(MAP), diastolic arterial pressure(DAP), heart rate(HR), saturation, Bispectralindex(BIS), latencies of auditory evoked potentials(AEP) waves(V.wave,Nawave,Pawave, Nbwave), and spectral edge frequency(SEF) values were measured.. The patients were divided into four groups comprised of 13 individuals.  In the induction, the patients were administered: 1.Group; propofol 2,5 mg/kg+ rocuronium 0,7 mg/kg 2.Group; propofol 2,5 mg/kg+ rocuronium 0,7 mg/kg+fentanyl 3mcg/kg 3.Group;propofol2,5 mg/kg+rocuronium0,7 mg/kg+fentanyl 6mcg/kg 4.Group;propofol2,5 mg/kg+rocuronium0,7 mg/kg+fentanyl 9mcg/kg The measurements were repeated in the first minute of induction(T2). Intubation was performed in the third minute of induction, then the measurements were repeated(T3). Demographics were similiar between groups. According to the SAP,DAP,MAP,HR values; a significant increase was found in the group 1 compared to group 4 at T3. There was a significant difference also between the group 1 and group 3 in MAP and HR measures. No significant difference was found between the groups in terms of BIS. There was not a significant difference between the groups also in terms of SEF1-2. AEP wave latencies(V.wave,Na,Pa,Nb) were found different between the time intervals. Wave latencies were increased at T2 compared to T1 and decreased at T3 compared to T2 in all the groups. The statistically significant difference was found between fentanyl 0 group and fentanyl 9 mcg/kg group in terms of Nb latency values. In conclusion, AEP is found to be more reliable than BIS and EEG when concerning the responses to induction and intubation with using fentanyl. We also observed that Nbwave latency response is the most significant latency of AEP waves.
      PubDate: 04/13/2014 10:15:02 pm
  • Comparison of the beneficial and adverse effects of inhaled and injectable
           anaesthetics: A mini-review.

    • Abstract: Introduction: The use of anaesthetics to minimize pain and distress of the animal during surgical procedures or euthanasia is vital. There are two major types of anesthesia, the inhaled (ether, halothane, the “fluranes” family) and injectable (barbiturates, steroids, dissociative agents, neuroleptanalgesics and propofol) anaesthetics, and both classes have advantages and disadvantages. This mini-review focus in discussing the most commonly used methods of anesthesia in laboratory animals, and to evaluate their advantages and disadvantages due to controversies regarding the best choice for anesthesia. Conclusion: Inhaled and injectable anaestheticshave particularities that should be taken into consideration before their use. Thus, a proper evaluation of the protocol for anesthesia should consider animal welfare, pharmacokinetics and adverse effects of the drug, which could affect the organ to be studied. In addition, the need for equipment and technical expertise, as well as the best route of administration, should be considered.
      PubDate: 04/13/2014 10:15:02 pm
  • The influence of anaesthetics drugs on immune response: From inflammation
           to immunosuppression.

    • Abstract: Introduction: The immune system protects us from infections through coordinate action of its components. Patients and animals undergoing surgery and anesthesia show alterations in the immune response. Methods: Since it is difficult to isolate the effects of anaesthetic drugs from surgery, diverse in vitrostudies with human immune cells or in-vivo with animals models have been used to study the effect of anaesthetic drugs on the immune system. Here, we review the effects of some of the most common anaesthetic drugs on the immune system, in particular on the effects within 24 hours after their administration, describing their effects on cells and cytokines of the innate and acquired immune system. Results: These studies have demonstrated diverse effects, such as changes in immune cells counts and functionality, and on the secretion patterns of diverse cytokines affecting the inflammatory response in the postoperative period. Discussion and conclusion: The effects of anaesthetic drugs on the immune system are clinically important, because the amount and function of the immune cells, as well as the balance between the pro and anti-inflammatory cytokines secretion are related to postoperative infections and tissue injury.
      PubDate: 04/13/2014 10:15:02 pm
  • Anaesthetic technique and cancer recurrence: Current understanding.

    • Abstract: Introduction: Over the last decade, dozens of studies have been published that examine the effect of anesthetic technique on cancer recurrence. In this article, we review the literature on the hypothesis that anesthetic and analgesic technique may impact long-term outcomes after oncologic surgery. Methods: The literature in this review was obtained from queries conducted on Google Scholar, PubMed, and MEDLINE. Search terms included – ‘anesthesia and cancer’, ‘IV anesthetics and cancer’, ‘volatile anesthetics and cancer’, ‘opioids and cancer’, anesthesia and tumor metastasis’, ‘regional anesthesia and cancer’, ‘local anesthetics and cancer’. Results: 5 in vitro, 7 animal, 5 clinical retrospective, and 2 prospective randomized control trials were included in our review. Conclusions: We may have to consider the conflicting evidence presented before us and adjust our current clinical practice in those oncologic patients where there is sufficient data to support an “anti-cancer” anesthetic
      PubDate: 04/13/2014 10:15:02 pm
  • Mitigation of pain and anaesthetic drugs.

    • Abstract: Inroduction: Anesthetics are used for pain management in patient surgery. They may interact with different levels of pain transmission in the body and by doing so anesthetics encounter with immune system. Due to this, alterations in immune response occurs which may lead to complications in patient after surgery. Materials and Methods: The information was collected and compiled from scientific literature present in different databases viz., Science Direct, PubMed, MEDLINE, Books and Google Scholar. Discussion: Literature search revealed that there are four elements of pain transmission viz. transduction, transmission , modulation  and perception. The nociceptive pathway is involved into the experience of pain and is modified by both psychosocial factors and damage/ or inflammation within tissues. There are different types of anesthetics used by the clinicians which have effect on one or more than one element of pain transmission. Use of anesthetics during preoperative treatment have impact on immune elements which results into other ailments in patients post operatively. Conclusion: Anesthetics manage pain using various mechanisms. There is need to explore and use multi modal technique of anesthetics having minimum post operative side effects.
      PubDate: 04/13/2014 10:15:02 pm
  • Anaesthetic considerations for robotic assisted cardiac surgery.

    • Abstract: The abstract will be provided by the corresponding author in due course.
      PubDate: 04/13/2014 10:15:02 pm
  • A novel approach to improving the safety of patients undergoing lumbar
           laminectomy surgery.

    • Abstract: The anesthesiology field has recently embraced the use of checklists to obviate the need for long-term memory. The aviation industry has shown that checklists increase safety outcomes and reduce the need for active memory to achieve tasks properly. The use of checklists in anesthesia in the prone laminectomy  patient will reduce bad outcomes  specifically POVL, peripheral nerve injuries and cervical injuries . Checklists are derived from IPT (Informational Processing Theory). Anesthetists training with checklists will learn the proper processes with less actual experience and should have safer outcomes. The aim of this paper is to demonstrate that the use of checklists in anesthesia will increase safety without reliance on short term memory ,improve customer satisfaction, and reduce mortality and morbidity. I have concluded that there is a national trend in medicine toward the use of checklists just as in other industries. Checklists have proven effective in reducing mortality and morbidity in surgeries by various authors .Checklists in anesthesia training reduce dependence on active memory and increase safety of outcomes and make decisions more evidence based and consistent. Checklists may enhance post-op screening for possible complications.
      PubDate: 04/13/2014 10:15:02 pm
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Heriot-Watt University
Edinburgh, EH14 4AS, UK
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