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DERMATOLOGY AND VENEREOLOGY (164 journals)                     

Showing 1 - 164 of 164 Journals sorted alphabetically
Acta Dermato-Venereologica     Open Access   (Followers: 12)
Acta Dermatovenerologica Croatica     Open Access   (Followers: 1)
Actas Dermo-Sifiliograficas     Full-text available via subscription   (Followers: 3)
Actas Dermo-Sifiliográficas (English Edition)     Full-text available via subscription   (Followers: 2)
Advances in Dermatology     Full-text available via subscription   (Followers: 15)
Advances in Skin & Wound Care     Hybrid Journal   (Followers: 30)
African Journal of AIDS Research     Hybrid Journal   (Followers: 8)
AIDS     Hybrid Journal   (Followers: 24)
AIDS Care: Psychological and Socio-medical Aspects of AIDS/HIV     Hybrid Journal   (Followers: 10)
AIDS Patient Care and STDs     Hybrid Journal   (Followers: 3)
AIDS Research and Human Retroviruses     Hybrid Journal   (Followers: 9)
AIDS Research and Therapy     Open Access   (Followers: 15)
AIDS Research and Treatment     Open Access   (Followers: 2)
Aktuelle Dermatologie     Hybrid Journal   (Followers: 7)
Allergo Journal     Full-text available via subscription   (Followers: 2)
American Journal of Clinical Dermatology     Full-text available via subscription   (Followers: 26)
American Journal of Dermatopathology     Hybrid Journal   (Followers: 18)
Anais Brasileiros de Dermatologia     Open Access   (Followers: 2)
Anaplastology     Open Access  
Annales de Dermatologie et de Vénéréologie     Full-text available via subscription  
Archives de Pédiatrie     Full-text available via subscription  
Archives de sciences sociales des religions     Open Access   (Followers: 1)
Archives des Maladies du Coeur et des Vaisseaux - Pratique     Hybrid Journal  
Archives of Dermatological Research     Hybrid Journal   (Followers: 7)
Archives of Gerontology and Geriatrics     Hybrid Journal   (Followers: 13)
Archives of Industrial Hygiene and Toxicology     Open Access   (Followers: 8)
Archives of Medical Research     Hybrid Journal   (Followers: 3)
Archives of Physical Medicine and Rehabilitation     Hybrid Journal   (Followers: 58)
Archivio di Ortopedia e Reumatologia     Hybrid Journal  
Asian Journal of Dermatology     Open Access   (Followers: 2)
ästhetische dermatologie & kosmetologie     Full-text available via subscription  
Australasian Journal of Dermatology     Hybrid Journal   (Followers: 8)
Berkala Ilmu Kesehatan Kulit dan Kelamin / Periodical of Dermatology and Venereology     Open Access  
Biomedical Dermatology     Open Access  
BMC Dermatology     Open Access   (Followers: 13)
BMJ Sexual & Reproductive Health     Hybrid Journal   (Followers: 2)
British Journal of Dermatology     Hybrid Journal   (Followers: 54)
Case Reports in Dermatological Medicine     Open Access   (Followers: 2)
Case Reports in Dermatology     Open Access   (Followers: 9)
Clinical and Experimental Dermatology     Hybrid Journal   (Followers: 13)
Clinical Dermatology Review     Open Access   (Followers: 5)
Clinical Skin Cancer     Full-text available via subscription  
Clinical, Cosmetic and Investigational Dermatology     Open Access   (Followers: 10)
Clinics in Dermatology     Hybrid Journal   (Followers: 14)
Contact Dermatitis     Hybrid Journal   (Followers: 8)
Cosmetics     Open Access   (Followers: 5)
Current Dermatology Reports     Hybrid Journal   (Followers: 7)
Current Fungal Infection Reports     Hybrid Journal   (Followers: 5)
Current HIV Research     Hybrid Journal   (Followers: 7)
Current HIV/AIDS Reports     Hybrid Journal   (Followers: 6)
Current Sexual Health Reports     Hybrid Journal   (Followers: 3)
Cutaneous and Ocular Toxicology     Hybrid Journal   (Followers: 10)
Der Hautarzt     Hybrid Journal   (Followers: 2)
Dermatitis     Hybrid Journal   (Followers: 1)
Dermato-Endocrinology     Open Access   (Followers: 2)
Dermatología Venezolana     Open Access  
Dermatologic Clinics     Full-text available via subscription   (Followers: 4)
Dermatologic Reviews     Hybrid Journal  
Dermatologic Surgery     Hybrid Journal   (Followers: 9)
Dermatologic Therapy     Hybrid Journal   (Followers: 2)
Dermatologica Sinica     Open Access  
Dermatological Nursing     Full-text available via subscription   (Followers: 2)
Dermatology     Full-text available via subscription   (Followers: 20)
Dermatology and Cosmetic     Open Access   (Followers: 8)
Dermatology and Therapy     Open Access   (Followers: 4)
Dermatology Online Journal     Open Access   (Followers: 1)
Dermatology Reports     Open Access   (Followers: 3)
Dermatology Research and Practice     Open Access   (Followers: 4)
Dermatology Times     Free  
Dermatopathology     Open Access   (Followers: 3)
Egyptian Journal of Dermatology and Venerology     Open Access   (Followers: 1)
EMC - Cosmetologia Medica e Medicina degli Inestetismi Cutanei     Full-text available via subscription  
EMC - Dermatología     Full-text available via subscription   (Followers: 1)
European Journal of Dermatology     Hybrid Journal   (Followers: 15)
Experimental Dermatology     Hybrid Journal   (Followers: 10)
Expert Review of Dermatology     Hybrid Journal   (Followers: 15)
Forum Dermatologicum     Hybrid Journal  
Graefe's Archive for Clinical and Experimental Ophthalmology     Hybrid Journal   (Followers: 9)
Güncel Dermatoloji Dergisi     Open Access  
HautinForm     Full-text available via subscription  
hautnah     Hybrid Journal  
hautnah dermatologie     Hybrid Journal  
HIV & AIDS Review     Full-text available via subscription   (Followers: 13)
HIV Clinical Trials     Hybrid Journal   (Followers: 5)
HIV Medicine     Hybrid Journal   (Followers: 3)
Indian Dermatology Online Journal     Open Access   (Followers: 3)
Indian Journal of Dermatology     Open Access   (Followers: 2)
Indian Journal of Dermatology, Venereology and Leprology     Open Access   (Followers: 4)
Indian Journal of Dermatopathology and Diagnostic Dermatology     Open Access  
Indian Journal of Drugs in Dermatology     Open Access   (Followers: 1)
Indian Journal of Paediatric Dermatology     Open Access   (Followers: 2)
Indian Journal of Sexually Transmitted Diseases and AIDS     Open Access   (Followers: 2)
International Archives of Medicine     Open Access   (Followers: 3)
International Journal of Dermatology     Hybrid Journal   (Followers: 14)
International Journal of Dermatology and Clinical Research     Open Access   (Followers: 2)
International Journal of Research in Dermatology     Open Access   (Followers: 1)
International Journal of STD & AIDS     Hybrid Journal   (Followers: 7)
International Journal of Women's Dermatology     Open Access   (Followers: 1)
International STD Research & Reviews     Open Access   (Followers: 1)
JAAD Case Reports     Open Access   (Followers: 1)
JAIDS : Journal of Acquired Immune Deficiency Syndromes     Hybrid Journal   (Followers: 4)
JAMA Dermatology     Full-text available via subscription   (Followers: 49)
JAMA Facial Plastic Surgery     Full-text available via subscription   (Followers: 13)
JMIR Dermatology     Open Access   (Followers: 1)
Journal of AIDS & Clinical Research     Open Access   (Followers: 3)
Journal of Clinical & Experimental Dermatology Research     Open Access   (Followers: 6)
Journal of Clinical and Investigative Dermatology     Open Access   (Followers: 2)
Journal of Cosmetic Dermatology     Hybrid Journal   (Followers: 11)
Journal of Cosmetics, Dermatological Sciences and Applications     Open Access   (Followers: 7)
Journal of Cutaneous Immunology and Allergy     Open Access  
Journal of Cutaneous Medicine and Surgery     Full-text available via subscription  
Journal of Dermatological Research     Open Access  
Journal of Dermatological Science     Hybrid Journal   (Followers: 2)
Journal of Dermatological Science Supplement     Full-text available via subscription   (Followers: 1)
Journal of Dermatological Treatment     Hybrid Journal   (Followers: 2)
Journal of Dermatology & Dermatologic Surgery     Open Access   (Followers: 1)
Journal of General-Procedural Dermatology & Venereology Indonesia     Open Access  
Journal of HIV/AIDS & Social Services     Hybrid Journal   (Followers: 9)
Journal of Investigative Dermatology     Hybrid Journal   (Followers: 28)
Journal of Investigative Dermatology Symposium Proceedings     Full-text available via subscription  
Journal of Sexual Medicine     Hybrid Journal   (Followers: 6)
Journal of Sexually Transmitted Diseases     Open Access   (Followers: 3)
Journal of Skin and Stem Cell     Open Access   (Followers: 3)
Journal of Skin Cancer     Open Access   (Followers: 3)
Journal of Surgical Dermatology     Open Access   (Followers: 1)
Journal of the American Academy of Dermatology     Full-text available via subscription   (Followers: 37)
Journal of the Dermatology Nurses' Association     Hybrid Journal   (Followers: 3)
Journal of the Egyptian Women’s Dermatologic Society     Partially Free  
Journal of the European Academy of Dermatology and Venereology     Hybrid Journal   (Followers: 15)
Journal of the International AIDS Society     Open Access   (Followers: 10)
Journal of the Saudi Society of Dermatology & Dermatologic Surgery     Open Access   (Followers: 1)
Karger Kompass Dermatologie     Full-text available via subscription  
Karger Kompass Pneumologie     Full-text available via subscription   (Followers: 1)
Langenbeck's Archives of Surgery     Hybrid Journal   (Followers: 4)
Medical and Surgical Dermatology     Hybrid Journal   (Followers: 1)
Medical Mycology     Open Access   (Followers: 4)
Nepal Journal of Dermatology, Venereology & Leprology     Open Access   (Followers: 1)
Neurobehavioral HIV Medicine     Open Access   (Followers: 2)
OA Dermatology     Open Access   (Followers: 1)
Open AIDS Journal     Open Access  
Open Dermatology Journal     Open Access  
Perspectives On Sexual and Reproductive Health     Hybrid Journal   (Followers: 7)
Pigment International     Open Access   (Followers: 1)
Psoriasis : Targets and Therapy     Open Access   (Followers: 4)
Revista Internacional de Ciencias Podológicas     Open Access  
SAHARA : Journal of Social Aspects of HIV / AIDS Research Alliance     Open Access   (Followers: 5)
Scars, Burns & Healing     Open Access  
Serbian Journal of Dermatology and Venereology     Open Access   (Followers: 1)
Sex Education: Sexuality, Society and Learning     Hybrid Journal   (Followers: 5)
Sexual & Reproductive Healthcare     Hybrid Journal   (Followers: 2)
Sexual Health     Hybrid Journal   (Followers: 4)
Sexually Transmitted Diseases     Hybrid Journal   (Followers: 7)
Sexually Transmitted Infections     Hybrid Journal   (Followers: 6)
Skin Appendage Disorders     Full-text available via subscription   (Followers: 1)
Skin Pharmacology and Physiology     Full-text available via subscription   (Followers: 7)
Skin Research and Technology     Hybrid Journal   (Followers: 6)
Southern African Journal of HIV Medicine     Open Access   (Followers: 3)
Sri Lanka Journal of Sexual Health and HIV Medicine     Open Access  
Studies in Gender and Sexuality     Hybrid Journal   (Followers: 21)
Surgical & Cosmetic Dermatology     Open Access   (Followers: 3)
The Journal of Dermatology     Hybrid Journal   (Followers: 4)
The Rose Sheet     Full-text available via subscription   (Followers: 2)
Vestnik dermatologii i venerologii     Open Access  
Veterinary Dermatology     Hybrid Journal   (Followers: 8)

           

Similar Journals
Journal Cover
Current Dermatology Reports
Number of Followers: 7  
 
  Hybrid Journal Hybrid journal (It can contain Open Access articles)
ISSN (Online) 2162-4933
Published by Springer-Verlag Homepage  [2626 journals]
  • Tildrakizumab for Moderate-to-Severe Chronic Plaque Psoriasis: a Review of
           the Literature
    • Abstract: Purpose of Review To highlight the most recent findings regarding the efficacy and safety of tildrakizumab in the treatment of chronic plaque psoriasis. Recent Findings Recent clinical trials have shown tildrakizumab to be more efficacious than placebo or etanercept. There are no head-to-head trials directly comparing tildrakizumab to any IL-23 p19, IL-17, or IL-17R inhibitor. Common adverse effects included headache, upper respiratory infection, nasopharyngitis, and cough. Summary Since tildrakizumab is a new biologic, there is currently a paucity of available evidence evaluating tildrakizumab in a comparative manor with respect to other biologic therapies. Tildrakizumab may be a useful addition in the armamentarium of available therapies, especially for patients who have failed other agents. Additional head-to-head trials are needed to better assess the comparative efficacy of tildrakizumab in relation to other biologic therapies.
      PubDate: 2019-03-01
       
  • Update on Risankizumab for Psoriasis
    • Abstract: Purpose of Review This review highlights the latest data on risankizumab, including efficacy and safety data from recent clinical trials. Recent Findings In multiple phase 3 clinical trials, risankizumab was shown to be safe and efficacious. Risankizumab demonstrated superior efficacy to leading active comparators for the induction and maintenance of clear skin and was shown to have a safety profile similar to other biologic therapies currently on the market. Summary Targeted biologic medications for plaque psoriasis have provided insight into the complex immune pathways that are now understood to lead to the development of several autoimmune diseases including plaque psoriasis. Risankizumab, a novel, fully human monoclonal antibody against the IL-23p19 subunit, is currently under investigation for the treatment of moderate-to-severe plaque psoriasis and shows promise to provide complete and lasting skin clearance with convenient dosing for patients. Future studies are needed to explore the long-term safety and efficacy of risankizumab beyond 5 years of therapy.
      PubDate: 2019-03-01
       
  • Biosimilars for Psoriasis—Experience from Europe
    • Abstract: Purpose of Review Over the last several years, major changes have occurred in Europe regarding the use of biosimilars. Some countries such as Norway, Denmark, and the United Kingdom (UK) have a relatively high market penetration of biosimilars, whereas in other European countries, biosimilar uptake is low. The objectives of this review are to describe the use of biosimilars in selected European countries, using “real-life” information from members of the International Psoriasis Council (IPC) who are key opinion leaders in dermatology. The use of biosimilars for patients with psoriasis is continuously discussed and reviewed by the IPC, through in-person meetings by members of the Biosimilar Working Group (BSWG). Recent Findings In preparation for this paper, we surveyed the use of biosimilars for patients with psoriasis through European BSWG members, who were asked to describe the situation in their countries. The survey collected information from each IPC councilor regarding the use of biosimilars currently on the market, guidelines for interchangeability, traceability, and naming of these agents. In addition, information regarding pricing, access, and physician/patient education was obtained. The status of biosimilars was discussed at an IPC biosimilar working group roundtable event which was held in Stockholm on June 28th, 2018. Summary With increased use of biosimilars likely in the future, the IPC will continue to provide leadership, education, and guidance for dermatologists to maximize the challenges presented by the adoption of biosimilars into clinical practice and improve the choice of biologic treatment for patients with moderate-severe psoriasis.
      PubDate: 2019-03-01
       
  • Nanotechnology for Psoriasis Therapy
    • Abstract: Purpose of Review To summarize the use of nanotechnology-based drug delivery systems for psoriasis therapies, focusing on recent studies of treatment efficacy in humans and murine models. Recent Findings Both topical and oral psoriasis medications, in addition to alternative psoriasis therapies and siRNAs targeting genes involved in the pathogenesis of psoriasis, have been incorporated into nanocarriers. Numerous studies demonstrate that nanocarriers can enhance the efficacy and reduce side effects of their included drugs through increased skin retention, sustained release, and decreased systemic absorption. However, the number of studies in humans is limited and while the short-term use of nanocarriers appears safe, long-term outcomes are unknown. Additionally, few studies compare different types of nanocarriers, making it difficult to recommend which types of nanocarriers are the best. Summary While recent research has demonstrated the benefit of nanotechnology-based drug delivery systems for psoriasis, more research, especially in humans, is needed to optimize drug-loaded nanocarriers for clinical use.
      PubDate: 2019-03-01
       
  • Healing Chronic Wounds: Current Challenges and Potential Solutions
    • Abstract: Purpose of Review The purpose of this review is to raise awareness, examine the challenges faced by wound care researchers, and explore opportunities for potential improvements. Recent Findings Chronic wounds are associated with significant morbidity and mortality, and they represent a major medical and financial burden. Despite this, no new therapy has received FDA efficacy approval for the treatment of chronic wounds since 1997. Previous preclinical studies using animal models did not translate to human wounds due to inherent limitations of experimental models, variability in assessment methods, and overall experimental design. Clinical trials continued to be challenged by the balance of the inclusion and exclusion criteria, the high cost and time expenditure of the trials, and the constraint of a single FDA-acceptable outcome of complete wound closure. Summary Wound research faces multiple challenges in both preclinical and clinical research that slowed progress and development of efficacious therapies. Solutions to such challenges will provide new opportunities for improved study design in the future.
      PubDate: 2018-12-01
       
  • Use of Lasers in Wound Healing: How to Best Utilize Laser Technology to
           Prevent Scar Formation
    • Abstract: Purpose of Review The purpose of this review is to evaluate the efficacy of early intervention in wound healing on scar formation across multiple scar types and progressions. The types of scars consist of hypertrophic, atrophic, keloid, and contracture scars. The sources of scarring include inflammatory diseases (e.g., acne), surgery, burn, and trauma. Recent Findings Minimal published research has been done regarding laser treatment in wound healing. Some studies have found promise in minor treatment of surgical wounds but few have sufficient clinical relevance. Recently, further studies have been conducted including examination of aggressive laser treatment in burn and trauma victims. Results have been positive and raise the question of which wounds would benefit from treatment. Summary Early intervention with laser treatment is a promising path in wound healing to prevent scarring. While more research remains to be done, emerging studies and practices provide increasing support for its use as a viable and potentially life-changing treatment for many patients.
      PubDate: 2018-12-01
       
  • Current Psoriasis Efficacy Outcome Measures in Clinical Trials
    • Abstract: Purpose of Review This review sought to examine currently used psoriasis efficacy outcome measures. In particular, we wanted to know what outcome measures are currently being used most frequently, in addition to the advantages and disadvantages of each outcome measure. Recent Findings In the past year, Psoriasis Area and Severity Index (PASI) was the most frequently used outcome measure in phase III and IV clinical trials evaluating psoriasis treatments. PASI scores were also the most frequently used primary outcome measure. Psoriasis Scalp Severity Index (PSSI) was the most commonly utilized regional physician reported outcome measure and Dermatology Quality of Life Index (DLQI) was the most commonly used patient reported outcome. Summary It is important for clinical trials to utilize outcome measures that are both accurate and take into account patients’ perspectives. Standardization of outcome measures will allow for better comparison of treatments across clinical trials.
      PubDate: 2018-12-01
       
  • Patient Education in Atopic Dermatitis: Why It Is Needed and How to
           Improve It
    • Abstract: Purpose of Review Demonstrate the need and objectives of patient education in atopic dermatitis (AD), provide an overview of the most recent studies regarding patient education, and propose new approaches to improve educational programs. Recent Findings Different models of patient education programs exist, and their structures depend on social and economic conditions. An active participation of patients is needed to improve new models of educational programs. Healthcare professionals who work with AD patients must have a comprehensive view of the many aspects involved in this disease, which includes psychological, environmental, social, financial, and cultural aspects. Summary AD is a complex disease and has a clear impact in patients’ quality of life. Patients are often frustrated and confused by the information they receive. This information can often be conflicting and overwhelming. Education for patients with AD is now being proposed as an important step in major treatment guidelines. Most studies of patient education demonstrate a positive impact in patients’ clinical outcomes, adherence, and quality of life.
      PubDate: 2018-12-01
       
  • Skin Barrier Function and Atopic Dermatitis
    • Abstract: Purpose of Review The purpose of this review was to highlight the importance of the skin barrier in the development of atopic dermatitis (AD). Recent Findings Skin barrier function relies on the stratum corneum (SC) and tight junction. These components are deranged in the AD epidermis. Deficiency in filaggrin gives rise to abnormal epidermal integrity. The intercellular lipid composition, ratio, and organization are found to be disturbed. Keratinocyte shedding from the SC is also impaired. Tight junction proteins are reduced and result in sweat leakage into the skin surface. Summary Strategies to enhance skin barrier strength will alleviate AD symptoms and may prevent the disease.
      PubDate: 2018-12-01
       
  • Complementary and Alternative Methods for Treatment of Acne Vulgaris: a
           Systematic Review
    • Abstract: Purpose of Review To review the current literature regarding complementary and alternative treatment options for acne vulgaris. Recent Findings Acne vulgaris is an increasingly prevalent disease worldwide. While conventional methods of treatment are still primarily used to treat acne, complementary and alternative methods of treatment are becoming utilized in conjunction or in place of prescription medications. Summary Studies have shown comparable benefit of Complementary and Alternative Medicine (CAM) therapies to conventional treatment. Oral green tea extract was a moderately effective treatment of inflammatory acne without significant side effects. Nicotinamide oral and topical preparations demonstrated efficacy in the treatment of moderate inflammatory acne without significant side effects. Oral zinc gluconate was not as effective as oral minocycline in the treatment of inflammatory acne. CAM therapy has relatively few reported side effects for acne vulgaris, and is mildly effective in treatment of inflammatory and comedonal acne. More studies are needed for further comparison of CAM modalities with each other as well as with conventional treatment.
      PubDate: 2018-12-01
       
  • Erythroderma and Figurate Erythemas
    • Abstract: Purpose of Review Erythroderma and figurate erythemas are common reasons for inpatient dermatologic consultation. This review provides an overview of the frequent causes of erythroderma and figurate erythemas in adults and children as well as highlights recent advances in our understanding of the pathomechanisms of these entities. Recent Findings With the advent of immunotherapy for the treatment of cancer, there are new medications that may result in drug-induced erythroderma. Additionally, the pathophysiology and immunologic milieu of erythroderma in psoriasis and cutaneous lymphoma has been investigated. More recent biologic agents may be used to treat erythroderma. Summary The differential diagnosis of erythroderma and figurate erythemas is broad and often related to underlying systemic diseases. Workup and treatment should focus on identifying and treating an underlying cause when applicable.
      PubDate: 2018-12-01
       
  • Epidemiology and Immunopathogenesis of Psoriasis and Its Comorbidities
    • Abstract: Purpose of Review While psoriasis has traditionally been considered primarily a skin and joint disorder, there is a new appreciation that psoriasis affects multiple organs. In fact, psoriasis is associated with several comorbidities that also affect the vasculature, guts, lung, kidney, and other tissues. This review aims to summarize the epidemiology and immunopathogenesis of psoriasis and its comorbidities. Recent Findings We reviewed the current literature characterizing the epidemiology and immune pathways of psoriasis and its comorbidities and report common inflammatory and immune pathways implicated in the pathogenesis of psoriasis and its comorbidities. Summary A variety of diseases are associated with psoriasis, including psoriatic arthritis, metabolic syndrome, atherosclerosis and cardiovascular disease, nonalcoholic fatty liver disease, inflammatory bowel disease, uveitis, and chronic obstructive pulmonary disease. These comorbidities share similar inflammatory and immune pathways with those that are classically implicated in psoriasis: especially the adipokines, TH17, and TNF-α.
      PubDate: 2018-12-01
       
  • Updates on Immunotherapy for the Treatment of Skin Cancer
    • Abstract: Purpose of Review Skin cancer is the most common malignancy in the USA, arising when mutated cells escape the host’s natural immune surveillance. Immunotherapy helps boost the host’s immune system, augmenting the antitumor response. Given the ability of the immune system to evolve with a tumor’s evasive maneuvers, it is not surprising that immunotherapy has demonstrated durable clinical benefit in patients with cancer, including certain types of skin cancers. Significant progress has been made with the recent development of immunotherapy for skin cancers. Recent Findings Here, we review the literature on immunotherapies used in the treatment of skin cancer, including immune checkpoint inhibitors, interferon, interleukin-2, BCG, talimogene laherparepvec, and imiquimod. Immune checkpoint inhibitors, which block CTLA-4 and PD-1 signaling pathways, have improved overall survival in patients with metastatic melanoma. The combination of nivolumab and ipilimumab has yielded higher overall survival rates than either agent alone, but at the price of higher rates of immune-related adverse events. In 2017, a PD-L1 inhibitor, avelumab, became the first FDA-approved treatment for patients with metastatic Merkel cell carcinoma. Summary Since 2011, new immunotherapy treatments, including CTLA-4, PD-1, and PD-L1 inhibitors, have become the mainstay of treatment for many advanced skin cancers, supplanting chemotherapy for first-line treatment of metastatic melanoma and Merkel cell carcinoma.
      PubDate: 2018-12-01
       
  • Immunology of Wound Healing
    • Abstract: Purpose of Review Chronic wounds are a tremendous burden on the healthcare system and lead to significant patient morbidity and mortality. Normal cutaneous wound healing occurs through an intricate and delicate interplay between the immune system, keratinocytes, and dermal cells. Each cell type contributes signals that drive the normal phases of wound healing: hemostasis, inflammation, proliferation, and remodeling. This paper reviews how various immunological cell types and signaling molecules influence the way wounds develop, persist, and heal. Recent Findings Concurrent with the achievement of hemostasis, neutrophils are the first cells to migrate to the wound bed, brought in by pro-inflammatory signals including IL-8. Their apoptosis and engulfment by macrophages (efferocytosis) provides a key signal to the local immune milieu, including macrophages, to transition to an anti-inflammatory, pro-repair state, where angiogenesis occurs and granulation tissue is laid down. Myofibroblasts, activated through contractile forces and signaling molecules, then drive remodeling, where granulation tissue becomes scar. Unchecked inflammation at this stage can result in abnormal scar formation. Summary Although the derangement of immune signals at any stage can result in impaired wound healing, recent research has shown that the key transition point lies between the inflammatory and the proliferative phases. This review summarizes the events that facilitate this transition and discusses how this process can be disrupted, leading to chronic, non-healing wounds.
      PubDate: 2018-12-01
       
  • Use of Stem Cells in Wound Healing
    • Abstract: Purpose of Review This review provides an overview of the principal stages of wound healing, the populations of endogenous and therapeutic stem cells, applications of stem cells in specific types of wounds, and current approaches of stem cell delivery for tissue regeneration. Recent Findings New uses of progenitor stem cells have been developed for the treatment of wounds. Stem cells improve wound healing through both local and paracrine effects. Stem cell populations of therapeutic utility include embryonic stem cells, induced pluripotent stem cells, adult bone marrow and adipose-derived mesenchymal stem cells, as well as stem cells from skin, cord blood, and extra fetal tissue. Induced pluripotent stem cells mitigate many of the ethical and immunogenic concerns related to use of embryonically derived stem cells. Summary Skin, the largest organ in the human body, serves as a protective barrier for mammals. Both aging and disease contribute to loss of skin barrier function, which can result in consequences such as chronic wounds. Recent advances in many types of stem cell therapy may revolutionize treatment of difficult wounds. Optimal techniques for obtaining and delivering stem cells are still being refined.
      PubDate: 2018-12-01
       
  • Dermatologic Reactions to Novel Immune Checkpoint Inhibitors
    • Abstract: Purpose of Review Dermatologic toxicities secondary to immune checkpoint inhibitors are prevalent and can be difficult to manage in the setting of underlying malignancy. This review summarizes the mucocutaneous adverse events associated with these agents and provides management options for varying degrees of presentation. Recent Findings Pruritus and rash are the most common dermatologic findings, but other manifestations such as vitiligo, lichenoid reactions, bullous pemphigoid, alopecia, and mucosal lesions have been observed. More recently, novel cases of rarer side effects, such as immunotherapy-induced scleroderma, fasciitis, and dermatomyositis, have been reported. Management often involves topical corticosteroids while more severe reactions require systemic treatment or discontinuation of immunotherapy. Summary Immune checkpoint inhibitors comprise a newer class of agents used in the treatment of various cancers. There is an increasing number and variety of cutaneous toxicities being reported as more of these immunotherapies are being used. Early diagnosis and treatment are crucial in effective management of these skin toxicities.
      PubDate: 2018-12-01
       
  • Dress for Success: a Review of Dressings and Wound Care in Hidradenitis
           Suppurativa
    • Abstract: Purpose of Review Hidradenitis suppurativa is characterized by lesions and draining sinus tracts in intimate locations. Although often overlooked, the selection of an effective, comfortable dressing can dramatically improve patients’ lives. We aimed to review dressings based on management of post-surgical and non-surgical wound dressings. We reviewed the characteristics and types of dressings used in patients with hidradenitis suppurativa and addressed recommendations for dressing post-surgical and non-surgical wounds. Recent Findings Available studies on dressings are few in number with small sample sizes. There were no studies comparing the efficacy of dressings in hidradenitis suppurativa patients. The types of dressings include superabsorbent/absorbent dressings, foam dressings, hydrofiber dressings, alginate dressings, silicone adherent dressings, non-adherent dressings, hydrocolloid dressings, silver-impregnated dressings, iodine-impregnated dressings, and honey-impregnated dressings, and platelet-rich plasma gel and hyaluronic acid scaffold dressings. Providers should consider the “TIME” acronym when assessing post-surgical and non-surgical wounds to select the appropriate dressing. Summary As an important component of wound healing, large, randomized controlled trials that compare dressing options for the management of wounds in hidradenitis suppurativa patients are needed.
      PubDate: 2018-12-01
       
  • Wound Healing with Botanicals: a Review and Future Perspectives
    • Abstract: Purpose of Review Botanicals have long played a crucial role in the management of chronic and infected wounds, yet the mechanistic basis of these therapies remains largely poorly understood by modern science. Recent Findings Studies have begun to unveil the mechanistic bases of botanical therapies for wound healing, but more work is necessary. Most notably, investigation into the growing conditions, post-harvest treatment, and pharmacological preparation of these botanicals has demonstrated their importance in terms of the chemical makeup and pharmacological activity of the final product used in pre-clinical and clinical studies. Summary This work evaluates the potential safety, efficacy, and mechanistic basis of some key botanical ingredients used in traditional medicine for wound care: aloe, marigold, and St. John’s Wort. Furthermore, perspectives on the future role that botanical natural products may play in anti-infective and wound care, innovations are explored.
      PubDate: 2018-12-01
       
  • Immune and Inflammatory Reponses to Staphylococcus aureus Skin Infections
    • Abstract: Purpose of Review There have been recent advances in our understanding of cutaneous immune responses to the important human skin pathogen, Staphylococcus aureus (S. aureus). This review will highlight these insights into innate and adaptive immune mechanisms in host defense and cutaneous inflammation in response to S. aureus skin infections. Recent Findings Antimicrobial peptides, pattern recognition receptors, and inflammasome activation function in innate immunity as well as T cells and their effector cytokines play a key role in adaptive immunity against S. aureus skin infections. In addition, certain mechanisms by which S. aureus contributes to aberrant cutaneous inflammation, such as in flares of the inflammatory skin disease atopic dermatitis, have also been identified. Summary These cutaneous immune mechanisms could provide new targets for future vaccines and immune-based therapies to combat skin infections and cutaneous inflammation caused by S. aureus.
      PubDate: 2018-12-01
       
  • Pediatric Inpatient Dermatology: New Insights on Severe Eruptions and
           Cutaneous Adverse Reactions
    • Abstract: Purpose of Review This manuscript reviews important advances in our understanding of severe eruptions and cutaneous adverse reactions in children. Recent Findings The latest research provides significant insights regarding severe cutaneous eruptions including coxsackievirus eruptions, mycoplasma-induced rash and mucositis, urticaria multiforme, erythema multiforme, and severe cutaneous adverse reactions. Recent literature expands our understanding of the incidence and cost, pathophysiology, and management considerations for pediatric patients with Stevens-Johnson syndrome and toxic epidermal necrolysis. Summary Pediatric inpatient cutaneous eruptions, from infectious and inflammatory to adverse reactions are very burdensome diseases. It is important to recognize salient features to initiate appropriate workup and management, particularly for patients with severe cutaneous adverse reactions for which early recognition of complications of disease and consultation with colleagues may minimize sequelae.
      PubDate: 2018-12-01
       
 
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