Subjects -> MEDICAL SCIENCES (Total: 8669 journals)
    - ALLERGOLOGY AND IMMUNOLOGY (218 journals)
    - ANAESTHESIOLOGY (120 journals)
    - CARDIOVASCULAR DISEASES (338 journals)
    - CHIROPRACTIC, HOMEOPATHY, OSTEOPATHY (21 journals)
    - COMMUNICABLE DISEASES, EPIDEMIOLOGY (235 journals)
    - DENTISTRY (294 journals)
    - DERMATOLOGY AND VENEREOLOGY (164 journals)
    - EMERGENCY AND INTENSIVE CRITICAL CARE (124 journals)
    - ENDOCRINOLOGY (151 journals)
    - FORENSIC SCIENCES (42 journals)
    - GASTROENTEROLOGY AND HEPATOLOGY (188 journals)
    - GERONTOLOGY AND GERIATRICS (138 journals)
    - HEMATOLOGY (157 journals)
    - HYPNOSIS (4 journals)
    - INTERNAL MEDICINE (176 journals)
    - LABORATORY AND EXPERIMENTAL MEDICINE (99 journals)
    - MEDICAL GENETICS (58 journals)
    - MEDICAL SCIENCES (2406 journals)
    - NURSES AND NURSING (367 journals)
    - OBSTETRICS AND GYNECOLOGY (207 journals)
    - ONCOLOGY (385 journals)
    - OPHTHALMOLOGY AND OPTOMETRY (141 journals)
    - ORTHOPEDICS AND TRAUMATOLOGY (170 journals)
    - OTORHINOLARYNGOLOGY (83 journals)
    - PATHOLOGY (100 journals)
    - PEDIATRICS (275 journals)
    - PHYSICAL MEDICINE AND REHABILITATION (158 journals)
    - PSYCHIATRY AND NEUROLOGY (833 journals)
    - RADIOLOGY AND NUCLEAR MEDICINE (192 journals)
    - RESPIRATORY DISEASES (104 journals)
    - RHEUMATOLOGY (79 journals)
    - SPORTS MEDICINE (81 journals)
    - SURGERY (406 journals)
    - UROLOGY, NEPHROLOGY AND ANDROLOGY (155 journals)

DERMATOLOGY AND VENEREOLOGY (164 journals)                     

Showing 1 - 164 of 164 Journals sorted alphabetically
Acta Dermato-Venereologica     Open Access   (Followers: 12)
Acta Dermatovenerologica Croatica     Open Access   (Followers: 1)
Actas Dermo-Sifiliograficas     Full-text available via subscription   (Followers: 3)
Actas Dermo-Sifiliográficas (English Edition)     Full-text available via subscription   (Followers: 2)
Advances in Dermatology     Full-text available via subscription   (Followers: 15)
Advances in Skin & Wound Care     Hybrid Journal   (Followers: 30)
African Journal of AIDS Research     Hybrid Journal   (Followers: 8)
AIDS     Hybrid Journal   (Followers: 24)
AIDS Care: Psychological and Socio-medical Aspects of AIDS/HIV     Hybrid Journal   (Followers: 10)
AIDS Patient Care and STDs     Hybrid Journal   (Followers: 3)
AIDS Research and Human Retroviruses     Hybrid Journal   (Followers: 9)
AIDS Research and Therapy     Open Access   (Followers: 15)
AIDS Research and Treatment     Open Access   (Followers: 2)
Aktuelle Dermatologie     Hybrid Journal   (Followers: 7)
Allergo Journal     Full-text available via subscription   (Followers: 2)
American Journal of Clinical Dermatology     Full-text available via subscription   (Followers: 26)
American Journal of Dermatopathology     Hybrid Journal   (Followers: 18)
Anais Brasileiros de Dermatologia     Open Access   (Followers: 2)
Anaplastology     Open Access  
Annales de Dermatologie et de Vénéréologie     Full-text available via subscription  
Archives de Pédiatrie     Full-text available via subscription  
Archives de sciences sociales des religions     Open Access   (Followers: 1)
Archives des Maladies du Coeur et des Vaisseaux - Pratique     Hybrid Journal  
Archives of Dermatological Research     Hybrid Journal   (Followers: 7)
Archives of Gerontology and Geriatrics     Hybrid Journal   (Followers: 13)
Archives of Industrial Hygiene and Toxicology     Open Access   (Followers: 8)
Archives of Medical Research     Hybrid Journal   (Followers: 3)
Archives of Physical Medicine and Rehabilitation     Hybrid Journal   (Followers: 58)
Archivio di Ortopedia e Reumatologia     Hybrid Journal  
Asian Journal of Dermatology     Open Access   (Followers: 2)
ästhetische dermatologie & kosmetologie     Full-text available via subscription  
Australasian Journal of Dermatology     Hybrid Journal   (Followers: 8)
Berkala Ilmu Kesehatan Kulit dan Kelamin / Periodical of Dermatology and Venereology     Open Access  
Biomedical Dermatology     Open Access  
BMC Dermatology     Open Access   (Followers: 13)
BMJ Sexual & Reproductive Health     Hybrid Journal   (Followers: 2)
British Journal of Dermatology     Hybrid Journal   (Followers: 54)
Case Reports in Dermatological Medicine     Open Access   (Followers: 2)
Case Reports in Dermatology     Open Access   (Followers: 9)
Clinical and Experimental Dermatology     Hybrid Journal   (Followers: 13)
Clinical Dermatology Review     Open Access   (Followers: 5)
Clinical Skin Cancer     Full-text available via subscription  
Clinical, Cosmetic and Investigational Dermatology     Open Access   (Followers: 10)
Clinics in Dermatology     Hybrid Journal   (Followers: 14)
Contact Dermatitis     Hybrid Journal   (Followers: 8)
Cosmetics     Open Access   (Followers: 5)
Current Dermatology Reports     Hybrid Journal   (Followers: 7)
Current Fungal Infection Reports     Hybrid Journal   (Followers: 5)
Current HIV Research     Hybrid Journal   (Followers: 7)
Current HIV/AIDS Reports     Hybrid Journal   (Followers: 6)
Current Sexual Health Reports     Hybrid Journal   (Followers: 3)
Cutaneous and Ocular Toxicology     Hybrid Journal   (Followers: 10)
Der Hautarzt     Hybrid Journal   (Followers: 2)
Dermatitis     Hybrid Journal   (Followers: 1)
Dermato-Endocrinology     Open Access   (Followers: 2)
Dermatología Venezolana     Open Access  
Dermatologic Clinics     Full-text available via subscription   (Followers: 4)
Dermatologic Reviews     Hybrid Journal  
Dermatologic Surgery     Hybrid Journal   (Followers: 9)
Dermatologic Therapy     Hybrid Journal   (Followers: 2)
Dermatologica Sinica     Open Access  
Dermatological Nursing     Full-text available via subscription   (Followers: 2)
Dermatology     Full-text available via subscription   (Followers: 20)
Dermatology and Cosmetic     Open Access   (Followers: 8)
Dermatology and Therapy     Open Access   (Followers: 4)
Dermatology Online Journal     Open Access   (Followers: 1)
Dermatology Reports     Open Access   (Followers: 3)
Dermatology Research and Practice     Open Access   (Followers: 4)
Dermatology Times     Free  
Dermatopathology     Open Access   (Followers: 3)
Egyptian Journal of Dermatology and Venerology     Open Access   (Followers: 1)
EMC - Cosmetologia Medica e Medicina degli Inestetismi Cutanei     Full-text available via subscription  
EMC - Dermatología     Full-text available via subscription   (Followers: 1)
European Journal of Dermatology     Hybrid Journal   (Followers: 15)
Experimental Dermatology     Hybrid Journal   (Followers: 10)
Expert Review of Dermatology     Hybrid Journal   (Followers: 15)
Forum Dermatologicum     Hybrid Journal  
Graefe's Archive for Clinical and Experimental Ophthalmology     Hybrid Journal   (Followers: 9)
Güncel Dermatoloji Dergisi     Open Access  
HautinForm     Full-text available via subscription  
hautnah     Hybrid Journal  
hautnah dermatologie     Hybrid Journal  
HIV & AIDS Review     Full-text available via subscription   (Followers: 13)
HIV Clinical Trials     Hybrid Journal   (Followers: 5)
HIV Medicine     Hybrid Journal   (Followers: 3)
Indian Dermatology Online Journal     Open Access   (Followers: 3)
Indian Journal of Dermatology     Open Access   (Followers: 2)
Indian Journal of Dermatology, Venereology and Leprology     Open Access   (Followers: 4)
Indian Journal of Dermatopathology and Diagnostic Dermatology     Open Access  
Indian Journal of Drugs in Dermatology     Open Access   (Followers: 1)
Indian Journal of Paediatric Dermatology     Open Access   (Followers: 2)
Indian Journal of Sexually Transmitted Diseases and AIDS     Open Access   (Followers: 2)
International Archives of Medicine     Open Access   (Followers: 3)
International Journal of Dermatology     Hybrid Journal   (Followers: 14)
International Journal of Dermatology and Clinical Research     Open Access   (Followers: 2)
International Journal of Research in Dermatology     Open Access   (Followers: 1)
International Journal of STD & AIDS     Hybrid Journal   (Followers: 7)
International Journal of Women's Dermatology     Open Access   (Followers: 1)
International STD Research & Reviews     Open Access   (Followers: 1)
JAAD Case Reports     Open Access   (Followers: 1)
JAIDS : Journal of Acquired Immune Deficiency Syndromes     Hybrid Journal   (Followers: 4)
JAMA Dermatology     Full-text available via subscription   (Followers: 49)
JAMA Facial Plastic Surgery     Full-text available via subscription   (Followers: 13)
JMIR Dermatology     Open Access   (Followers: 1)
Journal of AIDS & Clinical Research     Open Access   (Followers: 3)
Journal of Clinical & Experimental Dermatology Research     Open Access   (Followers: 6)
Journal of Clinical and Investigative Dermatology     Open Access   (Followers: 2)
Journal of Cosmetic Dermatology     Hybrid Journal   (Followers: 11)
Journal of Cosmetics, Dermatological Sciences and Applications     Open Access   (Followers: 7)
Journal of Cutaneous Immunology and Allergy     Open Access  
Journal of Cutaneous Medicine and Surgery     Full-text available via subscription  
Journal of Dermatological Research     Open Access  
Journal of Dermatological Science     Hybrid Journal   (Followers: 2)
Journal of Dermatological Science Supplement     Full-text available via subscription   (Followers: 1)
Journal of Dermatological Treatment     Hybrid Journal   (Followers: 2)
Journal of Dermatology & Dermatologic Surgery     Open Access   (Followers: 1)
Journal of General-Procedural Dermatology & Venereology Indonesia     Open Access  
Journal of HIV/AIDS & Social Services     Hybrid Journal   (Followers: 9)
Journal of Investigative Dermatology     Hybrid Journal   (Followers: 28)
Journal of Investigative Dermatology Symposium Proceedings     Full-text available via subscription  
Journal of Sexual Medicine     Hybrid Journal   (Followers: 6)
Journal of Sexually Transmitted Diseases     Open Access   (Followers: 3)
Journal of Skin and Stem Cell     Open Access   (Followers: 3)
Journal of Skin Cancer     Open Access   (Followers: 3)
Journal of Surgical Dermatology     Open Access   (Followers: 1)
Journal of the American Academy of Dermatology     Full-text available via subscription   (Followers: 37)
Journal of the Dermatology Nurses' Association     Hybrid Journal   (Followers: 3)
Journal of the Egyptian Women’s Dermatologic Society     Partially Free  
Journal of the European Academy of Dermatology and Venereology     Hybrid Journal   (Followers: 15)
Journal of the International AIDS Society     Open Access   (Followers: 10)
Journal of the Saudi Society of Dermatology & Dermatologic Surgery     Open Access   (Followers: 1)
Karger Kompass Dermatologie     Full-text available via subscription  
Karger Kompass Pneumologie     Full-text available via subscription   (Followers: 1)
Langenbeck's Archives of Surgery     Hybrid Journal   (Followers: 4)
Medical and Surgical Dermatology     Hybrid Journal   (Followers: 1)
Medical Mycology     Open Access   (Followers: 4)
Nepal Journal of Dermatology, Venereology & Leprology     Open Access   (Followers: 1)
Neurobehavioral HIV Medicine     Open Access   (Followers: 2)
OA Dermatology     Open Access   (Followers: 1)
Open AIDS Journal     Open Access  
Open Dermatology Journal     Open Access  
Perspectives On Sexual and Reproductive Health     Hybrid Journal   (Followers: 7)
Pigment International     Open Access   (Followers: 1)
Psoriasis : Targets and Therapy     Open Access   (Followers: 4)
Revista Internacional de Ciencias Podológicas     Open Access  
SAHARA : Journal of Social Aspects of HIV / AIDS Research Alliance     Open Access   (Followers: 5)
Scars, Burns & Healing     Open Access  
Serbian Journal of Dermatology and Venereology     Open Access   (Followers: 1)
Sex Education: Sexuality, Society and Learning     Hybrid Journal   (Followers: 5)
Sexual & Reproductive Healthcare     Hybrid Journal   (Followers: 2)
Sexual Health     Hybrid Journal   (Followers: 4)
Sexually Transmitted Diseases     Hybrid Journal   (Followers: 7)
Sexually Transmitted Infections     Hybrid Journal   (Followers: 6)
Skin Appendage Disorders     Full-text available via subscription   (Followers: 1)
Skin Pharmacology and Physiology     Full-text available via subscription   (Followers: 7)
Skin Research and Technology     Hybrid Journal   (Followers: 6)
Southern African Journal of HIV Medicine     Open Access   (Followers: 3)
Sri Lanka Journal of Sexual Health and HIV Medicine     Open Access  
Studies in Gender and Sexuality     Hybrid Journal   (Followers: 21)
Surgical & Cosmetic Dermatology     Open Access   (Followers: 3)
The Journal of Dermatology     Hybrid Journal   (Followers: 4)
The Rose Sheet     Full-text available via subscription   (Followers: 2)
Vestnik dermatologii i venerologii     Open Access  
Veterinary Dermatology     Hybrid Journal   (Followers: 8)

           

Similar Journals
Journal Cover
  • Obituary
    • Abstract: imageNo abstract available
      PubDate: Mon, 01 Jan 2018 00:00:00 GMT-
       
  • Acute and chronic radiodermatitis: clinical signs, pathophysiology, risk
           factors and management options
    • Authors: Robijns; Jolien; Laubach, Hans-Joachim
      Abstract: imageRadiodermatitis (RD) is a cutaneous reaction that occurs as a side-effect of radiotherapy during cancer treatment or sometimes after interventional radiology. There are two forms of RD depending on the time the skin reaction occurs. Acute skin reactions develop a few hours to weeks after the first exposure to radiation, whereas chronic RD can develop months, years or even decades after radiation. Both acute and chronic RD can substantially affect the patients’ quality of life and cosmetic outcome. Therefore, a proper prevention and treatment strategy for RD is needed. However, the scientific evidence for effective management options for RD is still lacking. In this paper, we review the most recent literature on the epidemiology, clinical signs, pathophysiology, risk factors and prevention and treatment options for acute and chronic RD caused by radiotherapy and interventional radiology.
      PubDate: Mon, 01 Jan 2018 00:00:00 GMT-
       
  • Expression of soluble and membrane-bound programmed death protein 1 in
           psoriasis vulgaris patients: a case-controlled study
    • Authors: Nagui; Noha A.R.; Sayed, Khadiga S.; Rashed, Laila A.; El Sayed, Hagar
      Abstract: imageBackground and aim Programmed cell death-1 (PD1) is an immunoreceptor that negatively regulates antigen receptor signaling and plays a critical role in the immunoregulation of autoimmune diseases.Objective The objective of this study was to assess both soluble programmed cell death-1 (sPD1) and membrane-bound PD1 levels in psoriatic patients, and to correlate them with disease severity.Patients and methods Twenty-one psoriatic patients and 20 age-matched and sex-matched controls were included. Full clinical examination was done and tissue and blood levels of PD1 were measured by enzyme-linked immunosorbent assay.Results Levels of sPD1 were significantly lower in patients than in controls (P
      PubDate: Mon, 01 Jan 2018 00:00:00 GMT-
       
  • TOX as a diagnostic and prognostic marker for mycosis fungoides
    • Authors: El-Hamd Neinaa; Yomna M.; Sallam, Fersan A.
      Abstract: imageBackground Mycosis fungoides (MF) is the most common primary cutaneous T-cell lymphoma that is characterized by clonal expansion of atypical CD4+ skin-homing T lymphocytes. Thymocyte selection-associated high mobility group-box protein (TOX) is a nuclear transcription factor, highly expressed in the thymus, and plays a critical role in CD4+ T-cell development. Therefore, it is likely that TOX activation may participate in the pathogenesis of MF.Objective To study the immunohistochemical expression of TOX in MF specimens in comparison with normal control skin specimens to shed light on its possible role in the pathogenesis of MF and to evaluate its efficacy as a possible diagnostic and prognostic marker for MF.Patients and methods The current study was carried out on 50 patients with different clinical types of MF and 25 normal control skin specimens. They were selected from the Outpatient Clinic of Dermatology and Venereology Department, Tanta University Hospitals. Skin specimens were obtained from each participant and examined routinely by hematoxylin and eosin and immunohistochemically by CD3, CD4, and TOX antibodies.Results There was a statistically significant increase in TOX immunohistochemical expression in MF specimens in comparison with normal control skin specimens. Statistically significant positive correlations were detected between the intensity of TOX expression in the dermis of MF specimens and the age of the patients, clinical progression of skin lesions, and TNM staging of the disease. In addition, there was a statistically significant positive correlation between the intensity of TOX expression, and the expression of both CD3 and CD4 both in the epidermis and in the dermis of MF specimens.Conclusion TOX may participate in the pathogenesis of MF. It could be considered a diagnostic and prognostic marker for MF. TOX expression correlates with increased risks of disease progression and a poor prognosis.
      PubDate: Mon, 01 Jan 2018 00:00:00 GMT-
       
  • Comparison of matrix metalloproteinase-1 expression in tumor-associated
           and nontumor-associated skin in patients with basal cell carcinoma
    • Authors: Shaheen; Maha A.; Asaad, Marwa K.; Elmasry, Ahmad I.; Zaki, Marwa S.E.; El Hefnawy, Nadia G.
      Abstract: imageBackground Basal cell carcinomas (BCC) produce large varieties of matrix metalloproteinases (MMPs). MMP induction occurs as a consequence of acute ultraviolet exposure, and may be some of the enhanced enzyme expression in tumor-associated skin reflects a response to solar radiation rather than an effect of the tumor itself. Of the MMP family, MMP-1 (collagenase-1) is the most abundantly expressed in various skin conditions.Objective The aim were to compare MMP-1 expression using immunohistochemistry in BCC different areas (tumoral, peritumoral, and safety margin) with nontumor associated, sun-exposed skin and to determine the exact role of MMP-1 in the pathogenesis of BCC and its invasiveness.Patients and methods This study included 24 BCC patients, who also represented the controls by taking punch biopsies from normal skin on the dorsa of their hands (as sun-exposed areas). Immunohistochemical assessment of MMP-1 in lesional skin biopsy and control biopsies was carried out.Results MMP-1 expression in peritumoral area of BCC was significantly higher than the tumoral area, safety margin, and control (P60 years) showed greater MMP-1 expression compared to their counterparts in younger age group (P
      PubDate: Mon, 01 Jan 2018 00:00:00 GMT-
       
  • Is vitamin D a participant in narrow-band ultraviolet B-induced
           pigmentation in patients with vitiligo'
    • Authors: Farag; Azza G. A.; Haggag, Magda M.; Muharram, Nashwa M.; Mahfouz, Reda; Elnaidany, Nada F.; Abd El Ghany, Hoda M.
      Abstract: imageBackground Because of its safety and efficacy, narrow-band ultraviolet B (NBUVB) therapy has found importance in vitiligo treatment. NBUVB may promote pigmentation in vitiligo through provoked vitamin D synthesis. However, little is known about this issue.Objective To estimate the serum levels of vitamin D in patients with vitiligo before and after NBUVB therapy and to correlate its posttreatment serum levels with repigmentation.Patients and methods Fifty patients with different degrees of vitiligo severity along with 25 age-matched, sex-matched, and skin phenotype-matched controls were enrolled in this study. Patients with vitiligo were treated with NBUVB thrice weekly for 12 weeks. Baseline serum 25-hydroxyvitamin D [25(OH)D] levels (compared with controls) by enzyme-linked immunosorbent assay and Vitiligo Area and Severity Index were estimated and then reevaluated after NBUVB sessions.Results Baseline 25(OH)D levels were significantly lower in vitiligo cases than controls. After 12 weeks of NBUVB therapy, a significant clinical improvement and increase in 25(OH)D concentrations were recorded; however, insignificant correlation between both was observed.Conclusion Low vitamin D level may play an active role in vitiligo development. Furthermore, vitamin D may participate partially in photo-induced melanogenesis. Therefore, the mechanism of NBUVB-induced pigmentation in vitiligo needs to be clarified.
      PubDate: Mon, 01 Jan 2018 00:00:00 GMT-
       
  • Serum and tissue levels of total antioxidant capacity in nonsegmental
           vitiligo
    • Authors: Hofny; Eman R.M.; Hasan, Howayda I.; Mohamed, Nahed A.; Bamatraf, Maysaa S.; Mahran, Ayman M.M.
      Abstract: imageBackground Vitiligo is the most common depigmentation disorder of the skin. Oxidative stress is implicated as one of the probable events involved in vitiligo pathogenesis, possibly contributing to destruction of melanocytes. The role of oxidative stress has not been fully understood in the etiopathogenesis of vitiligo.Objective To evaluate total antioxidant capacity (TAC) in the serum and tissue of patients with nonsegmental vitiligo.Patients and methods We examined TAC levels in serum and tissue of 48 patients with nonsegmental vitiligo and 30 healthy volunteers by colorimetric method using a commercial kit. The collected data were analyzed by SPSS version 16.Results The mean age of vitiligo patients was 32.6±12.4 years. Overall, 65% of patients were females, and 33% of patients have positive family history. The mean vitiligo area scoring index score was 5.84±6.57. TAC levels in sera and tissues were significantly lower in patients with vitiligo than in controls. Moreover, TAC levels were lower in the lesional skin than in the serum, perilesional, and unaffected skin of the patients. Decreased TAC levels were identified to be associated with unstable cases.Conclusion We proved a defective antioxidant system in vitiligo in the form of abnormally low serum and tissue levels of TAC. These findings provide further support for a free radical-mediated damage, especially on the tissue level, as an initial pathogenic event in destruction of melanocytes in vitiligo. Therefore, these findings support the role of antioxidant therapy in vitiligo.
      PubDate: Mon, 01 Jan 2018 00:00:00 GMT-
       
  • Immunohistochemical study of galectin-3 expression in basal cell
           carcinoma, squamous cell carcinoma, seborrheic keratosis and
           keratoacanthoma
    • Authors: Abd El-Naby; Naeim M.; El-Far, Nashwa N.; Shareef, Mohamed M.; El-Husseiny, Mohammed
      Abstract: imageBackground Galectin-3 is a ß-galactoside-binding lectin. It has a role in many normal and pathologic processes, such as tumor cell growth, apoptosis, cell motility, invasion, and metastasis.Objective To study the immunohistochemical expression of galectin-3 in seborrheic keratosis (SK) as an example of benign epidermal proliferation, basal cell carcinoma (BCC), and squamous cell carcinoma (SCC) as examples of malignant skin tumors and keratoacanthoma (KA).Patients and methods This study is a retrospective case–control study which included 40 cases: BCC, SCC, SK, KA with subsequent changes and eight paraffin blocks of site, gender and age matched healthy skin were used as controls. All were subjected to the hematoxylin and eosin and immunohistochemical staining for galectin-3.Results There was a statistically significant decrease in nuclear galectin-3 expression in the adjacent epidermis of BCC, SCC, SK, and KA as compared with normal epidermis. There was a statistically significant decrease in cytoplasmic and nuclear galectin-3 expression in BCC, SCC, SK, and KA compared with normal control. Moreover, nuclear galectin-3 expression was negatively correlated with increase in tumor size in BCC.Conclusion The marked decrease in nuclear galectin-3 expression suggests that decreased nuclear galectin-3 expression in tumors is an important factor in the progression from normal to tumor states. So, we speculate that nuclear galectin-3 expression may be one of the factors that contribute to tumor behavior in cutaneous BCC.
      PubDate: Mon, 01 Jan 2018 00:00:00 GMT-
       
  • Correlations among insulin-like growth factor-1, homocysteine, vitamin
           B12, and folic acid plasma levels following isotretinoin therapy in acne
           vulgaris patients
    • Authors: Yosef; Ayman; Dawoud, Noha M.; Gharib, Khaled
      Abstract: imageBackground Many metabolic disturbances have been reported following the use of oral isotretinoin for the treatment of acne vulgaris.Objective This study aimed to investigate the plasma levels of insulin-like growth factor-1 (IGF-1), homocysteine (Hcy), vitamin B12, and folic acid before and after isotretinoin treatment.Patients and methods Sixty patients with moderate to severe acne vulgaris were included. Using a chemiluminescent immunoassay, plasma IGF-1, Hcy, vitamin B12, and folic acid levels were measured at baseline and following 4 months of isotretinoin therapy.Results Post-treatment values of IGF-1, vitamin B12, and folic acid were significantly lower, whereas post-treatment Hcy was significantly higher compared with the baseline values. Post-treatment IGF-1 tended to be correlated negatively with patients’ age, whereas vitamin B12 showed a significant positive correlation. There was a highly significant positive correlation between post-treatment and baseline values of IGF-1 and also folic acid. There was a significant negative correlation between post-treatment IGF-1 and baseline Hcy. The IGF-1 mean post-treatment value was significantly lower in responding than nonresponding patients.Conclusion Isotretinoin-treated patients should be monitored closely for plasma IGF-1, Hcy, folic acid, and vitamin B12. Isotretinoin may act through a decrease in the IGF-1 plasma level. Younger patients might be at a higher risk of developing vitamin B12 deficiency and older patients might be at risk of IGF-1 deficiency following isotretinoin therapy. Hyperhomocysteinemia and IGF-1 deficiency seem to be caused by the direct effects of isotretinoin on liver function, unrelated to vitamin B12 and folic acid serum levels.
      PubDate: Mon, 01 Jan 2018 00:00:00 GMT-
       
  • Rituximab-induced serum sickness in pemphigus vulgaris
    • Authors: Awal; Guneet; Kaur, Simplepreet; Kaur, Jasleen; Sharma, Saurabh
      Abstract: imageRituximab is a B-cell depleting monoclonal antibody. Its use in autoimmune blistering disorders has gained popularity in the past few years. Its off-label use in severe and recalcitrant pemphigus vulgaris has been proved beneficial. Serum sickness is a type-III hypersensitivity reaction that could be seen after administration of biological immunotherapy like rituximab. It is seen 10–14 days after the 1st exposure and clinically presents as fever, maculopapular rash, and arthralgia. Serum sickness with rituximab has not been reported frequently in pemphigus vulgaris patients. Hence, we report a case of rituximab-induced serum sickness in a patient of pemphigus vulgaris.
      PubDate: Mon, 01 Jan 2018 00:00:00 GMT-
       
  • What is your diagnosis'
    • Authors: El-Komy; Mohamed H.M.
      Abstract: imageNo abstract available
      PubDate: Mon, 01 Jan 2018 00:00:00 GMT-
       
 
JournalTOCs
School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
Email: journaltocs@hw.ac.uk
Tel: +00 44 (0)131 4513762
 


Your IP address: 3.226.97.214
 
Home (Search)
API
About JournalTOCs
News (blog, publications)
JournalTOCs on Twitter   JournalTOCs on Facebook

JournalTOCs © 2009-