Subjects -> MEDICAL SCIENCES (Total: 8679 journals)
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DERMATOLOGY AND VENEREOLOGY (163 journals)                     

Showing 1 - 163 of 163 Journals sorted alphabetically
Acta Dermato-Venereologica     Open Access   (Followers: 12)
Acta Dermatovenerologica Croatica     Open Access   (Followers: 1)
Actas Dermo-Sifiliograficas     Full-text available via subscription   (Followers: 3)
Actas Dermo-Sifiliográficas (English Edition)     Full-text available via subscription   (Followers: 2)
Advances in Dermatology     Full-text available via subscription   (Followers: 15)
Advances in Skin & Wound Care     Hybrid Journal   (Followers: 30)
African Journal of AIDS Research     Hybrid Journal   (Followers: 8)
AIDS     Hybrid Journal   (Followers: 24)
AIDS Care: Psychological and Socio-medical Aspects of AIDS/HIV     Hybrid Journal   (Followers: 10)
AIDS Patient Care and STDs     Hybrid Journal   (Followers: 3)
AIDS Research and Human Retroviruses     Hybrid Journal   (Followers: 9)
AIDS Research and Therapy     Open Access   (Followers: 15)
AIDS Research and Treatment     Open Access   (Followers: 2)
Aktuelle Dermatologie     Hybrid Journal   (Followers: 7)
Allergo Journal     Full-text available via subscription   (Followers: 2)
American Journal of Clinical Dermatology     Full-text available via subscription   (Followers: 26)
American Journal of Dermatopathology     Hybrid Journal   (Followers: 18)
Anais Brasileiros de Dermatologia     Open Access   (Followers: 2)
Anaplastology     Open Access  
Annales de Dermatologie et de Vénéréologie     Full-text available via subscription  
Archives de Pédiatrie     Full-text available via subscription  
Archives de sciences sociales des religions     Open Access   (Followers: 1)
Archives des Maladies du Coeur et des Vaisseaux - Pratique     Hybrid Journal  
Archives of Dermatological Research     Hybrid Journal   (Followers: 7)
Archives of Gerontology and Geriatrics     Hybrid Journal   (Followers: 13)
Archives of Industrial Hygiene and Toxicology     Open Access   (Followers: 8)
Archives of Medical Research     Hybrid Journal   (Followers: 3)
Archives of Physical Medicine and Rehabilitation     Hybrid Journal   (Followers: 58)
Archivio di Ortopedia e Reumatologia     Hybrid Journal  
Asian Journal of Dermatology     Open Access   (Followers: 2)
ästhetische dermatologie & kosmetologie     Full-text available via subscription  
Australasian Journal of Dermatology     Hybrid Journal   (Followers: 8)
Berkala Ilmu Kesehatan Kulit dan Kelamin / Periodical of Dermatology and Venereology     Open Access  
Biomedical Dermatology     Open Access  
BMC Dermatology     Open Access   (Followers: 13)
BMJ Sexual & Reproductive Health     Hybrid Journal   (Followers: 2)
British Journal of Dermatology     Hybrid Journal   (Followers: 54)
Case Reports in Dermatological Medicine     Open Access   (Followers: 2)
Case Reports in Dermatology     Open Access   (Followers: 9)
Clinical and Experimental Dermatology     Hybrid Journal   (Followers: 13)
Clinical Dermatology Review     Open Access   (Followers: 5)
Clinical Skin Cancer     Full-text available via subscription  
Clinical, Cosmetic and Investigational Dermatology     Open Access   (Followers: 10)
Clinics in Dermatology     Hybrid Journal   (Followers: 14)
Contact Dermatitis     Hybrid Journal   (Followers: 8)
Cosmetics     Open Access   (Followers: 5)
Current Dermatology Reports     Hybrid Journal   (Followers: 7)
Current Fungal Infection Reports     Hybrid Journal   (Followers: 5)
Current HIV Research     Hybrid Journal   (Followers: 7)
Current HIV/AIDS Reports     Hybrid Journal   (Followers: 6)
Current Sexual Health Reports     Hybrid Journal   (Followers: 3)
Cutaneous and Ocular Toxicology     Hybrid Journal   (Followers: 10)
Der Hautarzt     Hybrid Journal   (Followers: 2)
Dermatitis     Hybrid Journal   (Followers: 1)
Dermato-Endocrinology     Open Access   (Followers: 2)
Dermatología Venezolana     Open Access  
Dermatologic Clinics     Full-text available via subscription   (Followers: 4)
Dermatologic Reviews     Hybrid Journal  
Dermatologic Surgery     Hybrid Journal   (Followers: 9)
Dermatologic Therapy     Hybrid Journal   (Followers: 2)
Dermatologica Sinica     Open Access  
Dermatological Nursing     Full-text available via subscription   (Followers: 2)
Dermatology     Full-text available via subscription   (Followers: 20)
Dermatology and Cosmetic     Open Access   (Followers: 8)
Dermatology and Therapy     Open Access   (Followers: 4)
Dermatology Online Journal     Open Access   (Followers: 1)
Dermatology Reports     Open Access   (Followers: 3)
Dermatology Research and Practice     Open Access   (Followers: 4)
Dermatopathology     Open Access   (Followers: 3)
Egyptian Journal of Dermatology and Venerology     Open Access   (Followers: 1)
EMC - Cosmetologia Medica e Medicina degli Inestetismi Cutanei     Full-text available via subscription  
EMC - Dermatología     Full-text available via subscription   (Followers: 1)
European Journal of Dermatology     Hybrid Journal   (Followers: 15)
Experimental Dermatology     Hybrid Journal   (Followers: 10)
Expert Review of Dermatology     Hybrid Journal   (Followers: 15)
Forum Dermatologicum     Hybrid Journal  
Graefe's Archive for Clinical and Experimental Ophthalmology     Hybrid Journal   (Followers: 9)
Güncel Dermatoloji Dergisi     Open Access  
HautinForm     Full-text available via subscription  
hautnah     Hybrid Journal  
hautnah dermatologie     Hybrid Journal  
HIV & AIDS Review     Full-text available via subscription   (Followers: 13)
HIV Clinical Trials     Hybrid Journal   (Followers: 5)
HIV Medicine     Hybrid Journal   (Followers: 3)
Indian Dermatology Online Journal     Open Access   (Followers: 3)
Indian Journal of Dermatology     Open Access   (Followers: 2)
Indian Journal of Dermatology, Venereology and Leprology     Open Access   (Followers: 4)
Indian Journal of Dermatopathology and Diagnostic Dermatology     Open Access  
Indian Journal of Drugs in Dermatology     Open Access   (Followers: 1)
Indian Journal of Paediatric Dermatology     Open Access   (Followers: 2)
Indian Journal of Sexually Transmitted Diseases and AIDS     Open Access   (Followers: 2)
International Archives of Medicine     Open Access   (Followers: 3)
International Journal of Dermatology     Hybrid Journal   (Followers: 14)
International Journal of Dermatology and Clinical Research     Open Access   (Followers: 2)
International Journal of Research in Dermatology     Open Access   (Followers: 1)
International Journal of STD & AIDS     Hybrid Journal   (Followers: 7)
International Journal of Women's Dermatology     Open Access   (Followers: 1)
International STD Research & Reviews     Open Access   (Followers: 1)
JAAD Case Reports     Open Access   (Followers: 1)
JAIDS : Journal of Acquired Immune Deficiency Syndromes     Hybrid Journal   (Followers: 4)
JAMA Dermatology     Full-text available via subscription   (Followers: 49)
JAMA Facial Plastic Surgery     Full-text available via subscription   (Followers: 13)
JMIR Dermatology     Open Access   (Followers: 1)
Journal of AIDS & Clinical Research     Open Access   (Followers: 3)
Journal of Clinical & Experimental Dermatology Research     Open Access   (Followers: 6)
Journal of Clinical and Investigative Dermatology     Open Access   (Followers: 2)
Journal of Cosmetic Dermatology     Hybrid Journal   (Followers: 11)
Journal of Cosmetics, Dermatological Sciences and Applications     Open Access   (Followers: 7)
Journal of Cutaneous Immunology and Allergy     Open Access  
Journal of Cutaneous Medicine and Surgery     Full-text available via subscription  
Journal of Dermatological Research     Open Access  
Journal of Dermatological Science     Hybrid Journal   (Followers: 2)
Journal of Dermatological Science Supplement     Full-text available via subscription   (Followers: 1)
Journal of Dermatological Treatment     Hybrid Journal   (Followers: 2)
Journal of Dermatology & Dermatologic Surgery     Open Access   (Followers: 1)
Journal of General-Procedural Dermatology & Venereology Indonesia     Open Access  
Journal of HIV/AIDS & Social Services     Hybrid Journal   (Followers: 9)
Journal of Investigative Dermatology     Hybrid Journal   (Followers: 28)
Journal of Investigative Dermatology Symposium Proceedings     Full-text available via subscription  
Journal of Sexual Medicine     Hybrid Journal   (Followers: 6)
Journal of Sexually Transmitted Diseases     Open Access   (Followers: 3)
Journal of Skin and Stem Cell     Open Access   (Followers: 3)
Journal of Skin Cancer     Open Access   (Followers: 3)
Journal of Surgical Dermatology     Open Access   (Followers: 1)
Journal of the American Academy of Dermatology     Full-text available via subscription   (Followers: 37)
Journal of the Dermatology Nurses' Association     Hybrid Journal   (Followers: 3)
Journal of the Egyptian Women’s Dermatologic Society     Partially Free  
Journal of the European Academy of Dermatology and Venereology     Hybrid Journal   (Followers: 15)
Journal of the International AIDS Society     Open Access   (Followers: 10)
Journal of the Saudi Society of Dermatology & Dermatologic Surgery     Open Access   (Followers: 1)
Karger Kompass Dermatologie     Full-text available via subscription  
Karger Kompass Pneumologie     Full-text available via subscription   (Followers: 1)
Langenbeck's Archives of Surgery     Hybrid Journal   (Followers: 4)
Medical and Surgical Dermatology     Hybrid Journal   (Followers: 1)
Medical Mycology     Open Access   (Followers: 4)
Nepal Journal of Dermatology, Venereology & Leprology     Open Access   (Followers: 1)
Neurobehavioral HIV Medicine     Open Access   (Followers: 2)
OA Dermatology     Open Access   (Followers: 1)
Open AIDS Journal     Open Access  
Open Dermatology Journal     Open Access  
Perspectives On Sexual and Reproductive Health     Hybrid Journal   (Followers: 7)
Pigment International     Open Access   (Followers: 1)
Psoriasis : Targets and Therapy     Open Access   (Followers: 4)
Revista Internacional de Ciencias Podológicas     Open Access  
SAHARA : Journal of Social Aspects of HIV / AIDS Research Alliance     Open Access   (Followers: 5)
Scars, Burns & Healing     Open Access  
Serbian Journal of Dermatology and Venereology     Open Access   (Followers: 1)
Sex Education: Sexuality, Society and Learning     Hybrid Journal   (Followers: 5)
Sexual & Reproductive Healthcare     Hybrid Journal   (Followers: 2)
Sexual Health     Hybrid Journal   (Followers: 4)
Sexually Transmitted Diseases     Hybrid Journal   (Followers: 7)
Sexually Transmitted Infections     Hybrid Journal   (Followers: 6)
Skin Appendage Disorders     Full-text available via subscription   (Followers: 1)
Skin Pharmacology and Physiology     Full-text available via subscription   (Followers: 7)
Skin Research and Technology     Hybrid Journal   (Followers: 6)
Southern African Journal of HIV Medicine     Open Access   (Followers: 3)
Sri Lanka Journal of Sexual Health and HIV Medicine     Open Access  
Studies in Gender and Sexuality     Hybrid Journal   (Followers: 21)
Surgical & Cosmetic Dermatology     Open Access   (Followers: 3)
The Journal of Dermatology     Hybrid Journal   (Followers: 4)
The Rose Sheet     Full-text available via subscription   (Followers: 2)
Vestnik dermatologii i venerologii     Open Access  
Veterinary Dermatology     Hybrid Journal   (Followers: 8)

           

Similar Journals
Journal Cover
HIV & AIDS Review
Journal Prestige (SJR): 0.134
Number of Followers: 13  
 
  Full-text available via subscription Subscription journal
ISSN (Print) 1730-1270
Published by Elsevier Homepage  [3200 journals]
  • The impact of the activities of Ghana AIDS Commission on new HIV
           infections in Ghana: An intervention time series analysis
    • Authors: Patrick Aboagye-Sarfo; Ute Mueller; James Cross
      Pages: 97 - 103
      Abstract: Publication date: Available online 15 April 2015
      Source:HIV & AIDS Review
      Author(s): Patrick Aboagye-Sarfo , Ute Mueller , James Cross
      The study examines the impact of Ghana AIDS Commission (GAC) activities on new HIV infections. Secondary data from 1 January 1996 to 31 December 2007 were obtained from the Ghana National AIDS Control Programme and Biostatistics Department of the Health Ministry. Intervention time series analysis was applied separately to the data from the northern and southern sectors due to data collection mechanism and location of two tertiary teaching hospitals. The impact of GAC activities is measured by the statistical significance of the coefficients of the intervention variable. The intervention variable is coded as zero (0) for the period before and one (1), the period after the GAC activities commenced. It was shown that the HIV incidence in the northern follows an integrated moving average model, whilst in the southern sectors an autoregressive integrated moving average model was the appropriate model. No significant impact of GAC activities was observed in the northern sector. In contrast the GAC activities in the southern sector were associated with a reduction in new HIV infections (male=−0.20±0.13, p <0.05; female=0.14±0.10, p <0.05), corresponding to a 15% and 18% reduction in male and female new HIV infections respectively in the sector. It can therefore be concluded that the GAC activities were a success. However, greater focus of GAC efforts in the northern sector is required to ensure that its activities have an impact on the incidence there.

      PubDate: 2015-04-17T18:14:44Z
      DOI: 10.1016/j.hivar.2015.03.003
      Issue No: Vol. 14, No. 4 (2015)
       
  • Clinical data and practical experience related to Stribild as an option in
           patients with HIV infection
    • Authors: Miłosz Parczewski; Magdalena Witak-Jędra
      Pages: 104 - 108
      Abstract: Publication date: Available online 16 April 2015
      Source:HIV & AIDS Review
      Author(s): Miłosz Parczewski , Magdalena Witak-Jędra
      Single tablet combination of tenofovir disoproxil fumarate, emtricitabine, elvitegravir and cobicistat [TDF/FTC/EVG/COBI] has been licensed for the use in HIV infected individuals as Stribild®. In treatment naïve subjects high virological efficacy of the regimen was proved. Recently use of this combination has been investigated as the switch option for the virologically suppressed individuals without drug resistance to the components of the compound. In twin studies – STRATEGY-NNRTI and STRATEGY-PI non-inferiority of the switch to TDF/FTC/EVG/COBI was confirmed, discontinuations due to adverse events were infrequent and no emergence of integrase drug resistance was observed. Simplification of the treatment using Stribild is an attractive, effective, safe and well tolerated option which also allows for the optimization of adherence. Elvitegravir-based therapies may be used to replace other antiretroviral regimens in virologically suppressed cases, with no compromise to the virological efficacy of the combination. Use of this novel integrase inhibitor seems to provide durable option for the long-term treatment. In this review we also present a case of the successful treatment optimization with TDF/FTC/EVG/COBI in a patient with poor adherence and protease resistance.

      PubDate: 2015-04-17T18:14:44Z
      DOI: 10.1016/j.hivar.2015.03.002
      Issue No: Vol. 14, No. 4 (2015)
       
  • Evaluation of a rapid testing kit utilising saliva to detect HIV
           infection: An Indian perspective
    • Authors: Prashant D. Shirke; Hemant R. Umarji
      Pages: 109 - 113
      Abstract: Publication date: Available online 27 June 2015
      Source:HIV & AIDS Review
      Author(s): Prashant D. Shirke , Hemant R. Umarji
      Aim Testing of saliva samples for the detection of HIV antibodies offers several advantages over serum. This study was undertaken to evaluate the performance of a rapid test, utilising saliva as a diagnostic medium for HIV infection. Background India has the third largest HIV infected population globally. Voluntary counselling and testing is a key element in comprehensive prevention. Advances in HIV therapeutics have highlighted the importance of expanded testing. The availability of a simple non-invasive reliable alternative to blood should increase access to HIV testing (and therefore to counselling and therapeutics) across a wide spectrum of the population. Materials and methods Subjects were selected from high risk and low risk groups and from a group in which conditions suggestive of HIV infection were present. Salivary samples were collected from 207 subjects and the final number included in the statistical analysis was 125 seropositive and 68 seronegative. The results were compared with standard serum testing procedures. Results Sensitivity, specificity, positive and negative predictive values were 100%, with 14 indeterminate results. Conclusion The combination of rapid testing technology and the use of an easily collected saliva sample offers an efficient and accurate alternative to conventional testing and can be appropriately applied to a variety of testing situations for the diagnosis of HIV infection. The technological aspects have been refined but the legal and ethical aspects need to be sorted out.

      PubDate: 2015-06-30T12:15:45Z
      DOI: 10.1016/j.hivar.2015.05.003
      Issue No: Vol. 14, No. 4 (2015)
       
  • Healthcare seeking practices of People Living with HIV and AIDS (PLHIV) in
           Bangladesh
    • Authors: Masum Billah
      Pages: 114 - 118
      Abstract: Publication date: Available online 28 May 2015
      Source:HIV & AIDS Review
      Author(s): Masum Billah
      Aim To explore the dynamics of healthcare seeking practices of people living with HIV and AIDS and examine the major socio-demographic factors determining their healthcare choices in Dhaka, Bangladesh. Background This study is about exploring the healthcare seeking practices of People Living with HIV and AIDS (PLHIV) in Bangladesh. Materials and methods The study employed both quantitative and qualitative methods of data collection. Samples were selected purposively using snowball sampling procedure for the survey. A total of 100 PLHIV were interviewed for the survey and 20 case studies were conducted for exploring the meaning, context and reasons for healthcare choices. Results Results of the study reveal that the socio-demographic and socio-economic status of PLHIV has a relation with healthcare seeking choices. In the study ‘perceived barriers’ emerged as determining factors in seeking health services by the PLHIV. Knowledge of the PLHIV on HIV/AIDS and STDs was found moderately high. Conclusion The state should play an active role in providing HIV/AIDS health services for the PLHIV with the help of monitoring and assessing the integrative performances of health practitioners directed by health ministry and local administration.

      PubDate: 2015-05-29T06:21:15Z
      DOI: 10.1016/j.hivar.2015.05.001
      Issue No: Vol. 14, No. 4 (2015)
       
  • The determinants of distress among HIV discordant couples
    • Authors: Shanuga Cherayi; Justin P. Jose
      Pages: 119 - 125
      Abstract: Publication date: Available online 28 June 2015
      Source:HIV & AIDS Review
      Author(s): Shanuga Cherayi , Justin P. Jose
      Aim A cross sectional study was conducted to examine the distress experienced by HIV infected discordant couples and their coping strategies. Background HIV discordant couples are those couples where one partner is HIV infected and the other is not. When one of the spouses of an approved marriage is an infected person, the psychological distress of the uninfected partner is likely to be high due to social aversion towards the couple, anxiety about the possibility of getting the infection to self. Materials and methods A total of 30 HIV discordant couples, receiving anti retro-viral therapy from a general hospital in Puducherry, were selected. Distress and coping were measured using Depression Anxiety and Stress Scale (DASS-21) and Brief Cope scale respectively. The descriptive and inferential statistics were used for data analysis. Results The result reveals that most of the respondents were experiencing moderate level of distress. The substance use (β =−.615; p <.05); venting (β =−.425; p <.05); planning (β =−.614; p <.05) and faith in religion (β =−.353; p <.05) were the significant negative predictor variable that reduced depression among HIV discordant couples. The substance use (β =−.647; p <.01); planning (β =.−546; p <.01); positive reframing (β =−.365; p <.05) and religious belief (β =−.436; p <.05) significantly contributing variables to anxiety of HIV discordant. Finally, substance use (β =−.489; p <.01); humour (β =−.345; p <.05) and faith in religion (β =−.336; p <.05) were the significant negative predictors that reduced the stress level of the respondents. Conclusion The study concludes that emphasizing the distress reduction and healthy coping promotion strategies for HIV discordant couples.

      PubDate: 2015-06-30T12:15:45Z
      DOI: 10.1016/j.hivar.2015.05.006
      Issue No: Vol. 14, No. 4 (2015)
       
  • Transmission dynamics of Trichomonas vaginalis and HIV/AIDS coinfection
    • Authors: C.P. Bhunu; S. Mushayabasa
      Pages: 126 - 132
      Abstract: Publication date: Available online 14 July 2015
      Source:HIV & AIDS Review
      Author(s): C.P. Bhunu , S. Mushayabasa
      Aim To explore the impact of Trichomonas Vaginalis on HIV transmission and vice-versa. Background Trichomonas vaginalis is known to aid the transmission and acquisition of HIV. The prevalence of TV is greater than the combined estimates of Chlamydia trachomatis and Neisseria gonorrhea. Material and methods We formulate and analyse a deterministic model of the coinfection of Trichomonas vaginalis and HIV/AIDS in order to assess their impact on each other. Conditions under which the endemic equilibria exists are stated. Results The endemic equilibrium point was shown to exist whenever the corresponding reproduction number is greater than unity. Results from model analysis suggests that Trichomonas vaginalis and HIV infections fuel one another. Conclusion Results from study shows that Trichomonas vaginalis and HIV fuel one another. Given the high costs of antiretroviral drugs in developing countries and the contribution Trichomonas vaginalis infections have on HIV transmissibility, treatment of Trichomonas Vaginalis infections may to a lesser extent help in the fight against the HIV/AIDS scouge. However, it is important to note that there is no single intervention of an STI (including periodic mass treatment of TV) that would significantly reduce HIV transmission.

      PubDate: 2015-07-14T15:20:46Z
      DOI: 10.1016/j.hivar.2015.05.005
      Issue No: Vol. 14, No. 4 (2015)
       
  • Possible role of tetracyclines on decreasing the accelerated aging process
           of well-controlled HIV patients on antiretroviral therapy
    • Authors: Martin Gnoni; Diana Otero; Scott Friedstrom; Steven Blatt; Julio Ramirez
      Pages: 133 - 137
      Abstract: Publication date: Available online 5 August 2015
      Source:HIV & AIDS Review
      Author(s): Martin Gnoni, Diana Otero, Scott Friedstrom, Steven Blatt, Julio Ramirez
      The aim of this study is to show the potential contribution of tetracyclines on decreasing the aging process of well-controlled HIV patients on antiretroviral therapy (ART). Chronic inflammation and immune activation play a significant role in the increase prevalence of non-AIDS defining illnesses, including cardiovascular, respiratory, neurologic, metabolic, renal and liver disease, along with different types of solid and hematologic cancers (aging). Low-level HIV replication, microbial translocation in mucosal surfaces, chronic co-infections, deposition of collagen in lymphoid tissue, increased oxidative stress, and immune senescence, are some of the features found on these patients. We reviewed some of the inflammatory pathways that these molecules might interrupt in order to decrease the aging process of well-controlled HIV patients on ART, which was already proven in animal models. Randomized clinical trials of tetracycline therapy in HIV infection are warranted in order to test this hypothesis.

      PubDate: 2015-08-07T21:22:23Z
      DOI: 10.1016/j.hivar.2015.07.001
      Issue No: Vol. 14, No. 4 (2015)
       
  • Facial dystonia – A rare initial presentation of acquired immune
           deficiency syndrome
    • Authors: Arpit Saxena; A.V. Ramesh; Poonam Raj Mehra; Manoj S
      Pages: 138 - 139
      Abstract: Publication date: Available online 31 March 2015
      Source:HIV & AIDS Review
      Author(s): Arpit Saxena , A.V. Ramesh , Poonam Raj Mehra , Manoj S
      Movement disorders could be a neurological complication of acquired immune deficiency syndrome (AIDS) and may sometimes represent the initial manifestation of HIV (Human Immune Deficiency Virus) infection. Presented here is an unusual case of facial dystonia – as a presenting symptom of HIV. In this case no separate aetiology for facial dystonia other than HIV infection could be found.

      PubDate: 2015-04-04T11:21:28Z
      DOI: 10.1016/j.hivar.2015.03.001
      Issue No: Vol. 14, No. 4 (2015)
       
  • Fatal systemic kaposi sarcoma in HIV-positive patient in the HAART-era
    • Authors: Hajer Ben Brahim; Ikbel Kooli; Monia Youssef; Abir Aouam; Wissem Melki; Chawki Loussaief; Adnene Toumi; Mohamed Chakroun
      Pages: 140 - 142
      Abstract: Publication date: Available online 15 July 2015
      Source:HIV & AIDS Review
      Author(s): Hajer Ben Brahim, Ikbel Kooli, Monia Youssef, Abir Aouam, Wissem Melki, Chawki Loussaief, Adnene Toumi, Mohamed Chakroun
      Epidemic or AIDS-associated kaposi sarcoma (KS) is an opportunistic polyclonal tumor associated with viral infection. The early presentation of KS typically involves mucocutaneous lesions and lymphadenopathy. More advanced disease can affect the lungs and other organs. We report a dramatic diffuse form of KS in treatment-naïve patient.

      PubDate: 2015-07-18T12:42:19Z
      DOI: 10.1016/j.hivar.2015.06.001
      Issue No: Vol. 14, No. 4 (2015)
       
  • Alterations in memory B cell subsets upon immunization against
           Streptococcus pneumoniae in HIV-1 infected adults
    • Authors: Olga Tsachouridou; Lemonia Skoura; Pantelis Zebekakis; Apostolia Margariti; Antonios Galanos; Dimitrios Pilalas; Michael Daniilidis; Nikolaos Malisiovas; Symeon Metallidis
      Pages: 143 - 147
      Abstract: Publication date: Available online 28 May 2015
      Source:HIV & AIDS Review
      Author(s): Olga Tsachouridou , Lemonia Skoura , Pantelis Zebekakis , Apostolia Margariti , Antonios Galanos , Dimitrios Pilalas , Michael Daniilidis , Nikolaos Malisiovas , Symeon Metallidis
      Aim Aim of our study was to assess diversities in memory B cell populations over time post vaccination with the 23-valent polysaccharide pneumococcal vaccine (PPV-23). Background Alterations of B cell subpopulations have been confirmed during HIV infection. HIV seems to disrupt several B cell subsets, impairs memory and leads to hyporesponsiveness to vaccines regardless antiretroviral intake. Materials and methods A cohort of treated and naive HIV-1 patients was immunized with PPV-23. B cell subpopulations were evaluated pre, 4 and 48 weeks post vaccination by flow cytometry. Results The frequency of total B, memory B cells (CD19+CD27+, BMC), resting memory B cells (CD19+CD27+CD21high, RM) and exhausted memory B cells (CD19+CD21lowCD27−, EM) was higher in treated patients with similar progression over time compared to naïve. Vaccination leads to significant depletion of EM B cells. Vaccine administration also marginally raised the circulating fractions of BMCs, though gradual depletion was observed in both groups. Mean fraction of IgM memory B (CD19+CD27+IgMhigh) cells and isotype-switched memory B cells (CD19+CD27+IgM−, ITS) was higher in the naive group. The percentage change of pre vaccination levels and week 4 and week 48 differed significantly between the two groups. Naïve patients also preserved higher fractions of activated memory B cells (CD19+CD21low+CD27+, AM) pre and post vaccination. Treated patients had higher proportions of RM cells, which differed significantly post vaccination. Conclusion Vaccination with the 23-PPV has an immunological effect on certain B cell subsets like RM and ITS memory B cells, triggering alterations of their counts on peripheral blood of HIV-infected patients. Moreover, HAART intake has controversial implication in few of these memory B cell populations.

      PubDate: 2015-05-29T06:21:15Z
      DOI: 10.1016/j.hivar.2015.05.002
      Issue No: Vol. 14, No. 4 (2015)
       
  • Kawasaki-like disease (KLD) in an adult with congenital HIV infection
    • Authors: Vasu Saini; Diana Otero Martin Gnoni Drew Cates Julio Ramirez
      Abstract: Publication date: Available online 12 December 2015
      Source:HIV & AIDS Review
      Author(s): Vasu Saini, Diana Otero, Martin Gnoni, Drew Cates, Julio Ramirez
      Background Kawasaki disease is an acute systemic vasculitis that predominantly affects young children and is rarely seen in adults. In the recent years, there have been a few cases in the literature reporting similar clinical picture in adults, especially in those with concurrent HIV, which lead us to present our findings and explore the illness further. Case report A 20-year-old African American female with congenital human immunodeficiency virus (HIV) infection, presented to the ER with complaints of chronic fatigue, fever (T max 103°F), arthralgia and sore throat since 2–3 weeks. She also had generalized pain, swelling and erythema of both hands and feet as well as conjunctival erythema with watery discharge since the same duration. An extensive infectious disease and rheumatologic work up in the hospital was negative. She had two prior admissions for similar complaints in less than a year with minimal response to NSAID and prednisone. The patient was started on a 5-day course of IV Immunoglobulin and Aspirin for suspected Kawasaki-like disease (KLD). She responded well and her symptoms resolved in a few days, strengthening our diagnosis. Conclusion It is a challenging task to diagnose Kawasaki-like disease in HIV infected adults due to a high likelihood of opportunistic infections or possible hypersensitivity to any one of the plethora of prescribed medications. A high suspicion of KLD is advised in HIV infected adults with severe immunosuppression and unexplained fever lasting>5 days to ensure timely diagnosis and treatment.

      PubDate: 2015-12-13T09:37:27Z
       
  • Effectiveness of HIV/AIDS educational intervention in increasing
           knowledge, attitude and practices for primary school teachers in some part
           of Africa
    • Authors: Mustapha Abdu; Ahmad Umar Bin Hj. Ibrahim Faisal Syed Hassan
      Abstract: Publication date: Available online 1 December 2015
      Source:HIV & AIDS Review
      Author(s): Mustapha Abdu, Ahmad Umar, Bin Hj. Ibrahim Faisal, Syed Hassan Syed Tajuddin, Binti Ismail Suria, Musa Garba Yakasai
      Human immunodeficiency virus (HIV) is virus that weakens the immune system of the body through destruction of the white blood cells. Whereas, AIDS term as; acquired immune deficiency syndrome is a disease due to the infection of HIV. Knowledge of health, and practices among teachers of primary school are scanty. Studies indicated that few teachers have heard or even became aware that HIV/AIDS is a viral infectious, and some of them lacked the knowledge about its mode of transmission with low attitudinal behaviours. Thus, this review paper discusses some health promotion measures and relevant information regarding, how the use of educational intervention in primary school teachers, could help in reducing the incidence cases of HIV/AIDS in Africa. We therefore recommend effective educational intervention programmes should be set for primary school teachers, in order that the teachers and the students could have a sound knowledge of health practices that will change their attitude which in turn reduce the risk of HIV/AIDS transmission.

      PubDate: 2015-12-04T12:12:33Z
       
  • Thirty years on with an HIV epidemic in Zimbabwe (1985–2015)
    • Authors: Walter Chingwaru; Jerneja Vidmar
      Abstract: Publication date: Available online 24 November 2015
      Source:HIV & AIDS Review
      Author(s): Walter Chingwaru, Jerneja Vidmar
      Zimbabwe, like many of her neighbours, is going through an HIV epidemic since 1985. It is imperative to assess progress with epidemic over the past three decades. We conducted a systematic review of reports in Pubmed/ScienceDirect, and a number of sentinel surveillance reports published by local and international organisations that have dealt with HIV/AIDS in the country, including the National AIDS Council of Zimbabwe, Ministry of Health and Child Welfare of Zimbabwe, UNAIDS and World Health Organisation. Thirty-five original research articles and 16 review articles, 4 surveillance reports and 2 conference reports met our inclusion criteria. The first 5 years of the epidemic were characterised by an exponential increase in prevalence (65-fold) and incidence (up to 13-fold) which were fuelled by high risk sexual behaviour. Comprehensive AIDS programmes that were launched between mid-1990s and 2015 and high mortality over the same period are thought to have played a role in slowing down the epidemic since the mid-2000s. Increased uptake of antiretroviral therapy (ART) and prevention-of-mother-to-child-transmission (PMTCT) (95%) prophylaxis accounted for a 70% drop in HIV-related mortality between 2003 and 2013. However, the epidemic has been characterised by a low paediatric ART coverage (35% in 2011 to 46.12% in 2013) and a recent increase in adolescent HIV prevalence. The epidemic has been driven by a number of social factors that include the local traditional beliefs and customs. A more holistic approach which deals with the epidemic in its socio-political context is required to effectively lower the country's HIV burden.

      PubDate: 2015-11-28T02:26:33Z
       
  • Incidence of HIV infection in 15 local government areas within Osun State
           in South West Nigeria: A two year analysis
    • Authors: V.O. Mabayoje; C.A. Akinleye
      Abstract: Publication date: Available online 18 November 2015
      Source:HIV & AIDS Review
      Author(s): V.O. Mabayoje, C.A. Akinleye
      Aim To determine the incidence of HIV among the adult population of selected government areas in Osun State Nigeria. Background Osun State is one of the states in Nigeria with the lowest HIV rates in Nigeria. Figures for 2013 revealed 2.7%. It is important that this figure is monitored constantly to ensure it does not rise above this and to enable health care organizations make necessary and timely interventions if and when necessary. Also surveys such as this provide vital data for international world health organizations in order that monitoring is made easier when they have access to data produced by such surveys. Materials and methods Trained counseling teams visited the 15 selected local government areas and with the cooperation of the recognized community leaders the HIV status was determined among adults living in these areas. Three testing kits from different manufacturers were utilized. Unigold, Statpak and Determine using recognized standard methods. The results would be subjected to statistical analysis SPSS version 10 was used for the statistical analysis. Results and conclusion Total number of subjects screened was 3250, of which 1144 (35.2%) were male and 2106 (64.8%) were female. The males were aged 36.72±21.19 and females 39.30±19.35. The screening kits used were Unigold, Determine and Statpak. Those positive were 18 (0.6%) with the female sex predominating. More intensive efforts should be made in terms of prevention to maintain and if possible reduce these figures.

      PubDate: 2015-11-20T06:33:50Z
       
  • Acknowledgement of Reviewers
    • Abstract: Publication date: 2015
      Source:HIV & AIDS Review, Volume 14, Issue 4


      PubDate: 2015-11-11T06:48:01Z
       
  • Echocardiographic assessment of left ventricular function in asymptomatic
           HIV patients: A single arm blinded study from north India
    • Authors: Abhishek Agrawal; Laxmikant Goyal Kamlesh Sharma C.L. Nawal Pradeep Mital
      Abstract: Publication date: Available online 1 October 2015
      Source:HIV & AIDS Review
      Author(s): Abhishek Agrawal, Laxmikant Goyal, Kamlesh Sharma, C.L. Nawal, Pradeep Mital, Dileep Kumar
      Aim To assess left ventricular (LV) function in HIV patients by two-dimensional (2D) echocardiography to determine the pattern of myocardial dysfunction, and any correlation between cardiac dysfunction and severity of HIV infection. Background Human immunodeficiency virus (HIV) infection may cause various cardiac dysfunctions in humans even in the asymptomatic state and its timely detection may have prognostic value. Materials and methods One hundred treatment naïve, asymptomatic HIV cases were subjected to trans-thoracic echocardiographic (2D, M-mode, pulse-wave, continuous-wave and colour Doppler) assessment by a single blinded cardiologist. Results Twenty-nine (29%) of 100 patients (mean age: 36.8 years; male: 54%) had echocardiographic abnormalities. Grade 1 diastolic dysfunction was present in 20, reduced fractional shortening in 12, reduced ejection fraction (<50%) in two (2%), and dilated cardiomyopathy, pericardial effusion and regional wall motion abnormality in one patient each. Four had both systolic and diastolic dysfunction. In patients with diastolic dysfunction, 17 had CD4 count <200/μl (P <0.001). Most cases with cardiac manifestation were in clinical stage III and IV. Cases having diastolic dysfunction had significantly different CD4 counts, haemoglobin level and erythrocyte sedimentation rate (ESR) values than the cases without cardiac dysfunction. CD4 counts were significantly negatively correlated with deceleration time (r =−0.2622, P <0.05) and iso-volumetric relaxation time (IVRT) (r =−0.3681, P <0.05) and significantly positively correlated with E/A ratio (r =+0.3291, P <0.05). Conclusions Twenty-nine (29%) HIV cases in relatively advanced clinical stage had cardiac dysfunction on echocardiography without overt cardiac manifestations. The CD4 cell counts significantly correlated with the presence of diastolic dysfunction.

      PubDate: 2015-10-01T05:00:09Z
       
  • Multiple spontaneous perforation of small bowel by Mycobacterium avium
           complex infection in an AIDS patient
    • Authors: Hadiseh Hosamirudsari; Hengameh Shahnavaz Nazila Mahooti
      Abstract: Publication date: Available online 8 September 2015
      Source:HIV & AIDS Review
      Author(s): Hadiseh Hosamirudsari, Hengameh Shahnavaz, Nazila Mahooti
      Disseminated Mycobacterium avium complex (MAC) infections occur in late stage of AIDS. Highly active antiretroviral therapy (HAART) decreases the incidence of MAC infection, but patients with low CD4 counts who have no access to HAART, are remained at risk. The intestine is involved in disseminated MAC which causes gastrointestinal tract symptoms. Spontaneous perforation of small bowel, only ileum by disseminated MAC is documented in one case report. We present a rare case of disseminated MAC infection that led to the multiple spontaneous perforation of small intestine in ileum and cecum. The patient deceased, despite immediate surgical intervention. Mycobacterium avium complex is an important cause of multiple, spontaneous small bowel perforation. We recommend administrating MAC prophylaxis in HIV positive patients who do not have access to HAART therapy.

      PubDate: 2015-09-10T08:13:19Z
       
  • Mutational analysis of HIV-1 viral protein U at Ser52 and Ser56 among the
           HIV-1 infected patients of Manipur
    • Authors: Adhikarimayum Lakhikumar; Sharma Thiyam Ramsing Singh Khuraijam Ranjana Devi Lisam
      Abstract: Publication date: Available online 21 August 2015
      Source:HIV & AIDS Review
      Author(s): Adhikarimayum Lakhikumar Sharma, Thiyam Ramsing Singh, Khuraijam Ranjana Devi, Lisam Shanjukumar Singh
      Background Phosphorylation by Casein kinase 2 at two conserved seryl residues, Ser52 and Ser56 at the cytoplasmic domain of HIV-1 Viral protein U (Vpu) are essential for inducing CD4 degradation. This study is conducted to investigate the variability of HIV-1 viral protein unique particularly at amino-acid position Ser52 and Ser56 among the HIV infected individuals in the northeastern region of India. Materials and methods Blood samples from 90 HIV-1 infected patients of Manipur have been studied by viral amplification and sequencing at vpu gene of HIV-1. For analysis of amino acid variation at Ser52 and Ser56, nucleic acid sequences were translated into amino acid and aligned with reference strain of HIV-1. Phylogenetic tree was also inferred among the studied samples. Results The results revealed that 93% of HIV-1 infected individuals harbored virus with conserved serine at both amino acid positions 52 and 56 of vpu which were known to have the ability to induce CD4 degradation while 1% harbored viral mutation at both Ser52 and Ser56, replaced by asparagine which has been predicted to may have lost the ability to induce CD4 degradation. Moreover, 5% and 1% of HIV-1 infected individuals were found to be infected with mutated virus at ser52 and ser56 of vpu respectively. Conclusion The overall finding of this study reveals that seryl residue of vpu at Ser52 and Ser56 was highly conserved among the HIV-1 infected individuals of the study population.

      PubDate: 2015-08-24T12:00:08Z
       
  • HIV-1 strategies to overcome the immune system by evading and invading
           innate immune system
    • Authors: Mohammad A.Y.; Alqudah Mahmoud M.M. Yaseen Mohammad M.S. Yaseen
      Abstract: Publication date: Available online 19 August 2015
      Source:HIV & AIDS Review
      Author(s): Mohammad A.Y. Alqudah, Mahmoud M.M. Yaseen, Mohammad M.S. Yaseen
      HIV-1 infection is a major public health problem and an important cause of death among adults. In light of innate immune system being the first, rapid and nonspecific response, this highlights the importance of exploiting the active arms of innate immunity to eradicate the invader and triggering a more specific immune response, the adaptive immune system. Each type of cells in the innate immune system has a unique distribution and function in the body and therefore differs in their ability to induce adaptive immune arms according to the stimuli. Any functional defect or alteration in the innate immune system can affect the adaptive arms of the immune system in terms of failure to overcome the battlefield with the invader. This review focuses on the relevant function of each member of the innate immune system and sheds the light on detailed mechanisms about how this smart virus invades and evades the immune system which opens new insights into the immunology and therapeutic targeting of HIV-1 infection.

      PubDate: 2015-08-20T16:29:26Z
       
  • Effects of stress on HIV infection progression
    • Authors: Jacek
      Abstract: Publication date: Available online 19 August 2015
      Source:HIV & AIDS Review
      Author(s): Jacek Kołodziej
      There is substantial body of evidence that psychosocial factors influence the disease progression in HIV infection. In particular, stress or stressful life events are considered important in terms of impacting the key biological markers of the disease – viral load and CD4 cell count. Both animal models and human research seem to prove that stance by examining various groups of patients (children and adults, males and females, MSM and heterosexual persons). There is no consensus as to the effects of stress-reducing interventions on improving the immune functioning of the patients, although there is research indicating that these techniques may be of benefit to the patients if used properly. There are two most often discussed biological models for explaining the mechanisms behind the mentioned effects – one relating to the actions of hypothalamus–pituitary–adrenal axis (HPA axis) and the second pointing to sympathetic nervous system (SNS) or sympathomedullary pathway (SAM). These two mechanisms should not be viewed as exclusive, but rather synergetic in action. Both of them, however, are not clearly understood and there are studies pointing to gaps in these theories. Further research is needed to examine the biological mechanisms and to distinguish the groups of patients that may benefit the most from psychological interventions.

      PubDate: 2015-08-20T16:29:26Z
       
 
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