Subjects -> MEDICAL SCIENCES (Total: 8529 journals)
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DERMATOLOGY AND VENEREOLOGY (164 journals)                     

Showing 1 - 164 of 164 Journals sorted alphabetically
Acta Dermato-Venereologica     Open Access   (Followers: 12)
Acta Dermatovenerologica Croatica     Open Access   (Followers: 1)
Actas Dermo-Sifiliograficas     Full-text available via subscription   (Followers: 3)
Actas Dermo-Sifiliográficas (English Edition)     Full-text available via subscription   (Followers: 2)
Advances in Dermatology     Full-text available via subscription   (Followers: 16)
Advances in Skin & Wound Care     Hybrid Journal   (Followers: 31)
African Journal of AIDS Research     Hybrid Journal   (Followers: 8)
AIDS     Hybrid Journal   (Followers: 23)
AIDS Care: Psychological and Socio-medical Aspects of AIDS/HIV     Hybrid Journal   (Followers: 9)
AIDS Patient Care and STDs     Hybrid Journal   (Followers: 3)
AIDS Research and Human Retroviruses     Hybrid Journal   (Followers: 9)
AIDS Research and Therapy     Open Access   (Followers: 15)
AIDS Research and Treatment     Open Access   (Followers: 2)
Aktuelle Dermatologie     Hybrid Journal   (Followers: 7)
Allergo Journal     Full-text available via subscription   (Followers: 2)
American Journal of Clinical Dermatology     Full-text available via subscription   (Followers: 26)
American Journal of Dermatopathology     Hybrid Journal   (Followers: 17)
Anais Brasileiros de Dermatologia     Open Access   (Followers: 2)
Anaplastology     Open Access  
Annales de Dermatologie et de Vénéréologie     Full-text available via subscription  
Archives de Pédiatrie     Full-text available via subscription  
Archives de sciences sociales des religions     Open Access   (Followers: 1)
Archives des Maladies du Coeur et des Vaisseaux - Pratique     Hybrid Journal  
Archives of Dermatological Research     Hybrid Journal   (Followers: 7)
Archives of Gerontology and Geriatrics     Hybrid Journal   (Followers: 13)
Archives of Industrial Hygiene and Toxicology     Open Access   (Followers: 8)
Archives of Medical Research     Hybrid Journal   (Followers: 3)
Archives of Physical Medicine and Rehabilitation     Hybrid Journal   (Followers: 55)
Archivio di Ortopedia e Reumatologia     Hybrid Journal  
Asian Journal of Dermatology     Open Access   (Followers: 2)
ästhetische dermatologie & kosmetologie     Full-text available via subscription  
Australasian Journal of Dermatology     Hybrid Journal   (Followers: 8)
Berkala Ilmu Kesehatan Kulit dan Kelamin / Periodical of Dermatology and Venereology     Open Access  
Biomedical Dermatology     Open Access  
BMC Dermatology     Open Access   (Followers: 13)
BMJ Sexual & Reproductive Health     Hybrid Journal   (Followers: 2)
British Journal of Dermatology     Hybrid Journal   (Followers: 54)
Case Reports in Dermatological Medicine     Open Access   (Followers: 2)
Case Reports in Dermatology     Open Access   (Followers: 10)
Clinical and Experimental Dermatology     Hybrid Journal   (Followers: 14)
Clinical Dermatology Review     Open Access   (Followers: 5)
Clinical Skin Cancer     Full-text available via subscription  
Clinical, Cosmetic and Investigational Dermatology     Open Access   (Followers: 10)
Clinics in Dermatology     Hybrid Journal   (Followers: 15)
Contact Dermatitis     Hybrid Journal   (Followers: 8)
Cosmetics     Open Access   (Followers: 5)
Current Dermatology Reports     Hybrid Journal   (Followers: 7)
Current Fungal Infection Reports     Hybrid Journal   (Followers: 5)
Current HIV Research     Hybrid Journal   (Followers: 7)
Current HIV/AIDS Reports     Hybrid Journal   (Followers: 6)
Current Sexual Health Reports     Hybrid Journal   (Followers: 3)
Cutaneous and Ocular Toxicology     Hybrid Journal   (Followers: 10)
Der Hautarzt     Hybrid Journal   (Followers: 2)
Dermatitis     Hybrid Journal   (Followers: 1)
Dermato-Endocrinology     Open Access   (Followers: 2)
Dermatología Venezolana     Open Access  
Dermatologic Clinics     Full-text available via subscription   (Followers: 4)
Dermatologic Reviews     Hybrid Journal  
Dermatologic Surgery     Hybrid Journal   (Followers: 8)
Dermatologic Therapy     Hybrid Journal   (Followers: 2)
Dermatologica Sinica     Open Access  
Dermatological Nursing     Full-text available via subscription   (Followers: 2)
Dermatology     Full-text available via subscription   (Followers: 20)
Dermatology and Cosmetic     Open Access   (Followers: 8)
Dermatology and Therapy     Open Access   (Followers: 4)
Dermatology Online Journal     Open Access   (Followers: 1)
Dermatology Reports     Open Access   (Followers: 3)
Dermatology Research and Practice     Open Access   (Followers: 4)
Dermatology Times     Free  
Dermatopathology     Open Access   (Followers: 3)
Egyptian Journal of Dermatology and Venerology     Open Access   (Followers: 1)
EMC - Cosmetologia Medica e Medicina degli Inestetismi Cutanei     Full-text available via subscription  
EMC - Dermatología     Full-text available via subscription   (Followers: 1)
European Journal of Dermatology     Hybrid Journal   (Followers: 15)
Experimental Dermatology     Hybrid Journal   (Followers: 10)
Expert Review of Dermatology     Hybrid Journal   (Followers: 14)
Forum Dermatologicum     Hybrid Journal  
Graefe's Archive for Clinical and Experimental Ophthalmology     Hybrid Journal   (Followers: 8)
Güncel Dermatoloji Dergisi     Open Access  
HautinForm     Full-text available via subscription  
hautnah     Hybrid Journal  
hautnah dermatologie     Hybrid Journal  
HIV & AIDS Review     Full-text available via subscription   (Followers: 13)
HIV Clinical Trials     Hybrid Journal   (Followers: 5)
HIV Medicine     Hybrid Journal   (Followers: 3)
Indian Dermatology Online Journal     Open Access   (Followers: 3)
Indian Journal of Dermatology     Open Access   (Followers: 2)
Indian Journal of Dermatology, Venereology and Leprology     Open Access   (Followers: 4)
Indian Journal of Dermatopathology and Diagnostic Dermatology     Open Access  
Indian Journal of Drugs in Dermatology     Open Access   (Followers: 1)
Indian Journal of Paediatric Dermatology     Open Access   (Followers: 2)
Indian Journal of Sexually Transmitted Diseases and AIDS     Open Access   (Followers: 2)
International Archives of Medicine     Open Access   (Followers: 3)
International Journal of Dermatology     Hybrid Journal   (Followers: 15)
International Journal of Dermatology and Clinical Research     Open Access   (Followers: 2)
International Journal of Research in Dermatology     Open Access   (Followers: 1)
International Journal of STD & AIDS     Hybrid Journal   (Followers: 7)
International Journal of Women's Dermatology     Open Access   (Followers: 1)
International STD Research & Reviews     Open Access   (Followers: 1)
JAAD Case Reports     Open Access   (Followers: 1)
JAIDS : Journal of Acquired Immune Deficiency Syndromes     Hybrid Journal   (Followers: 4)
JAMA Dermatology     Full-text available via subscription   (Followers: 49)
JAMA Facial Plastic Surgery     Full-text available via subscription   (Followers: 12)
JMIR Dermatology     Open Access   (Followers: 1)
Journal of AIDS & Clinical Research     Open Access   (Followers: 3)
Journal of Clinical & Experimental Dermatology Research     Open Access   (Followers: 6)
Journal of Clinical and Investigative Dermatology     Open Access   (Followers: 2)
Journal of Cosmetic Dermatology     Hybrid Journal   (Followers: 10)
Journal of Cosmetics, Dermatological Sciences and Applications     Open Access   (Followers: 7)
Journal of Cutaneous Immunology and Allergy     Open Access  
Journal of Cutaneous Medicine and Surgery     Full-text available via subscription  
Journal of Dermatological Research     Open Access  
Journal of Dermatological Science     Hybrid Journal   (Followers: 2)
Journal of Dermatological Science Supplement     Full-text available via subscription   (Followers: 1)
Journal of Dermatological Treatment     Hybrid Journal   (Followers: 2)
Journal of Dermatology & Dermatologic Surgery     Open Access   (Followers: 1)
Journal of General-Procedural Dermatology & Venereology Indonesia     Open Access  
Journal of HIV/AIDS & Social Services     Hybrid Journal   (Followers: 9)
Journal of Investigative Dermatology     Hybrid Journal   (Followers: 28)
Journal of Investigative Dermatology Symposium Proceedings     Full-text available via subscription  
Journal of Sexual Medicine     Hybrid Journal   (Followers: 6)
Journal of Sexually Transmitted Diseases     Open Access   (Followers: 3)
Journal of Skin and Stem Cell     Open Access   (Followers: 3)
Journal of Skin Cancer     Open Access   (Followers: 3)
Journal of Surgical Dermatology     Open Access   (Followers: 1)
Journal of the American Academy of Dermatology     Full-text available via subscription   (Followers: 37)
Journal of the Dermatology Nurses' Association     Hybrid Journal   (Followers: 3)
Journal of the Egyptian Women’s Dermatologic Society     Partially Free  
Journal of the European Academy of Dermatology and Venereology     Hybrid Journal   (Followers: 15)
Journal of the International AIDS Society     Open Access   (Followers: 10)
Journal of the Saudi Society of Dermatology & Dermatologic Surgery     Open Access   (Followers: 1)
Karger Kompass Dermatologie     Full-text available via subscription  
Karger Kompass Pneumologie     Full-text available via subscription   (Followers: 1)
Langenbeck's Archives of Surgery     Hybrid Journal   (Followers: 4)
Medical and Surgical Dermatology     Hybrid Journal   (Followers: 1)
Medical Mycology     Open Access   (Followers: 4)
Nepal Journal of Dermatology, Venereology & Leprology     Open Access   (Followers: 1)
Neurobehavioral HIV Medicine     Open Access   (Followers: 2)
OA Dermatology     Open Access   (Followers: 1)
Open AIDS Journal     Open Access  
Open Dermatology Journal     Open Access  
Perspectives On Sexual and Reproductive Health     Hybrid Journal   (Followers: 7)
Pigment International     Open Access   (Followers: 1)
Psoriasis : Targets and Therapy     Open Access   (Followers: 4)
Revista Internacional de Ciencias Podológicas     Open Access  
SAHARA : Journal of Social Aspects of HIV / AIDS Research Alliance     Open Access   (Followers: 5)
Scars, Burns & Healing     Open Access  
Serbian Journal of Dermatology and Venereology     Open Access   (Followers: 1)
Sex Education: Sexuality, Society and Learning     Hybrid Journal   (Followers: 5)
Sexual & Reproductive Healthcare     Hybrid Journal   (Followers: 2)
Sexual Health     Hybrid Journal   (Followers: 4)
Sexually Transmitted Diseases     Hybrid Journal   (Followers: 6)
Sexually Transmitted Infections     Hybrid Journal   (Followers: 6)
Skin Appendage Disorders     Full-text available via subscription   (Followers: 1)
Skin Pharmacology and Physiology     Full-text available via subscription   (Followers: 7)
Skin Research and Technology     Hybrid Journal   (Followers: 7)
Southern African Journal of HIV Medicine     Open Access   (Followers: 3)
Sri Lanka Journal of Sexual Health and HIV Medicine     Open Access  
Studies in Gender and Sexuality     Hybrid Journal   (Followers: 21)
Surgical & Cosmetic Dermatology     Open Access   (Followers: 3)
The Journal of Dermatology     Hybrid Journal   (Followers: 5)
The Rose Sheet     Full-text available via subscription   (Followers: 2)
Vestnik dermatologii i venerologii     Open Access  
Veterinary Dermatology     Hybrid Journal   (Followers: 8)

           

Similar Journals
Journal Cover
Archives of Medical Research
Journal Prestige (SJR): 1.009
Citation Impact (citeScore): 2
Number of Followers: 3  
 
  Hybrid Journal Hybrid journal (It can contain Open Access articles)
ISSN (Print) 0188-4409
Published by Elsevier Homepage  [3204 journals]
  • Brugada Syndrome Caused by Sodium Channel Dysfunction Associated with a
           SCN1B Variant A197V
    • Abstract: Publication date: Available online 16 March 2020Source: Archives of Medical ResearchAuthor(s): Linlin Wang, Zhonglin Han, Jian Dai, Kejiang Cao
       
  • Night Shift Work and Breast Cancer in Mexican Women
    • Abstract: Publication date: Available online 10 March 2020Source: Archives of Medical ResearchAuthor(s): Eduardo Hernández-Garduño
       
  • Potential Anticancer Effect of Celastrol on Hepatocellular Carcinoma by
           Suppressing CXCR4-related Signal and Impeding Tumor Growth in Vivo
    • Abstract: Publication date: Available online 10 March 2020Source: Archives of Medical ResearchAuthor(s): Chan Kun-Ming, Cheng Chih-Hsien, Lee Chen-Fang, Wu Ting-Jung, Chou Hong-Shiue, Lee Wei-Chen
       
  • Serum C1q/TNF-Related Protein-2 (CTRP2) Levels are Associated With
           Coronary Artery Disease (CAD) in Men
    • Abstract: Publication date: Available online 6 March 2020Source: Archives of Medical ResearchAuthor(s): Davod Ilbeigi, Mehran Khoshfetrat, Reza Afrisham, Bahador Rahimi, Sattar Gorgani-Firuzjaee
       
  • Helveticoside Exhibited p53-dependent Anticancer Activity Against
           Colorectal Cancer
    • Abstract: Publication date: Available online 6 March 2020Source: Archives of Medical ResearchAuthor(s): Na An, Ying Sun, Ligang Ma, Shengli Shi, Xiaoke Zheng, Weisheng Feng, Zhiming Shan, Yongguang Han, Le Zhao, Huiming Wu
       
  • CpG Oligodeoxynucleotides Induces Apoptosis of Human Bladder Cancer Cells
           via Caspase-3-Bax/Bcl-2-p53 Axis
    • Abstract: Publication date: Available online 3 March 2020Source: Archives of Medical ResearchAuthor(s): Yang Luo, Xiaoyi Fu, Ruizhen Ru, Bin Han, Fafu Zhang, Lihong Yuan, Hongsheng Men, Shulin Zhang, Sujuan Tian, Bin Dong, Minjie Meng
       
  • Oral Ciprofloxacin Pharmacokinetics in Healthy Mexican Volunteers and
           Other Populations: Is There Interethnic Variability'
    • Abstract: Publication date: Available online 3 March 2020Source: Archives of Medical ResearchAuthor(s): Suset J. Tolentino-Hernández, Leticia Cruz-Antonio, José Pérez-Urizar, Héctor A. Cabrera-Fuentes, Gilberto Castañeda-Hernández
       
  • Autologous CXCR4+ Hematopoietic Stem Cells Injected Into the Scar
           Tissue of Chronic Myocardial Infarction Patients Normalizes Tissue
           Contractility and Perfusion
    • Abstract: Publication date: Available online 26 February 2020Source: Archives of Medical ResearchAuthor(s): José Luis Aceves, Rafael Vilchis López, Paúl Mondragón Terán, Carmen Martínez Escobedo, Mario A. Marroquín Muciño, Guillermo García Castillo, Miriam Marmolejo Estrada, Fernando Rodríguez García, Guillermo Díaz Quiroz, Luis Felipe Montaño Estrada
       
  • Pulmonary Hypertension in Patients Starting Peritoneal Dialysis
    • Abstract: Publication date: Available online 26 February 2020Source: Archives of Medical ResearchAuthor(s): Oscar Orihuela, Ma de Jesus Ventura, Héctor A. Carmona-Ruiz, Luis-Efren Santos-Martinez, Alfonso Ramos Sánchez, Ramon Paniagua
       
  • IL-19 as a Biomarker for the Seveity of Acute Myocardial Infarction
    • Abstract: Publication date: Available online 26 February 2020Source: Archives of Medical ResearchAuthor(s): Liping Qi, Jianwei Zhang, Kui Wu, Shutian Shi, Qingwei Ji, Huangtai Miao, Bin Que
       
  • Effects of Moderate-To-Vigorous Physical Activity on Cancer-Related
           Fatigue in Patients With Colorectal Cancer: A Systematic Review and
           Meta-Analysis
    • Abstract: Publication date: Available online 26 February 2020Source: Archives of Medical ResearchAuthor(s): Liu Dun, Wu Xian-Yi, Jiang Xiao-Ying
       
  • Highly Expressed DLL4 and JAG1: Their Role in Incidence of Breast Cancer
           Metastasis
    • Abstract: Publication date: Available online 26 February 2020Source: Archives of Medical ResearchAuthor(s): Samir F. Zohny, Mazin A. Zamzami, Abdulrahman L. Al-Malki, Nora H. Trabulsi
       
  • Synergistic Apoptotic Effects of Bortezomib and Methylstat on Multiple
           Myeloma Cells
    • Abstract: Publication date: Available online 26 February 2020Source: Archives of Medical ResearchAuthor(s): Fatma Necmiye Kacı, Yağmur Kiraz, Demet Çekdemir, Yusuf Baran
       
  • Qualitative Study of the Processes of Transgender-Men Identity Development
    • Abstract: Publication date: Available online 26 February 2020Source: Archives of Medical ResearchAuthor(s): Tania Real-Quintanar, Rebeca Robles-García, María Elena Medina-Mora, Lucía Vázquez-Pérez, Martha Romero-Mendoza
       
  • γδ T Cells Number, CD200, and Flt3 Expression Is Associated with Higher
           Progression Free Survival in Patients with Chronic Myeloid Leukemia
    • Abstract: Publication date: Available online 26 February 2020Source: Archives of Medical ResearchAuthor(s): Rubiraida Molina-Aguilar, Laura Arcelia Montiel-Cervantes, Santa Victoria Anguiano-Peñaloza, Ruth Lezama, Jorge Vela-Ojeda, Elba Reyes-Maldonado
       
  • Very High Frequency of LDLR Gene Mutation p.asp360His Causing Familial
           Hypercholesterolemia in a Mexican Community in the state of Puebla
    • Abstract: Publication date: Available online 26 February 2020Source: Archives of Medical ResearchAuthor(s): Teresita De Jesús Hernández Flores, Juan Ramón González García, Yoaly Josefina Sánchez López, Norma Alejandra Vázquez Cárdenas, Ana Gabriela Colima Fausto, Sergio Yair Rodríguez Preciado, María Teresa Magaña Torres
       
  • Molecular Basis of the Beneficial Actions of Resveratrol
    • Abstract: Publication date: Available online 26 February 2020Source: Archives of Medical ResearchAuthor(s): Gastón Repossi, Undurti N. Das, Aldo Renato Eynard
       
  • Isopulegol, A Dietary Monoterpene Mitigates Hyperglycemia
           Mediated Oxidative and Endoplasmic Reticulum Stress in HFD/STZ
           Induced Diabetic Rats
    • Abstract: Publication date: Available online 26 February 2020Source: Archives of Medical ResearchAuthor(s): Chandrasekaran Sankaranarayanan, Karunanithi Kalaivani
       
  • Prognostic Factors Associating With Pro-oxidant-antioxidant Balance;
           Neutrophils to Lymphocytes Ratio, Vitamin D, Heat Shock Protein 27, and
           Red Cell Distribution Width
    • Abstract: Publication date: Available online 26 February 2020Source: Archives of Medical ResearchAuthor(s): Hamideh Ghazizadeh, Mohammad Reza Mirinezhad, Seyed Mohammad Reza Seyedi, Fatemeh Sadabadi, Mahsa Ahmadnezhad, Naghme Jaberi, Alireza Pasdar, Gordon A. Ferns, Habibollah Esmaily, Majid Ghayour-Mobarhan
       
  • High Glucose Content Abrogated the Normal Activity of Heat Shock Protein
           Signaling Pathway in Human Neuroblastoma Cells
    • Abstract: Publication date: Available online 25 February 2020Source: Archives of Medical ResearchAuthor(s): Leila Salimi, Sadegh Salarinasab, Reza Rahbarghazi, Alireza Nourazarian, Masoud Nikanfar, Çıgır Biray Avci, Bakiye Goker Bagca, Neslihan Pinar Ozates Ay, Milad Hasanpour
       
  • LINC01354 Promotes Osteosarcoma Cell Invasion by Up-regulating Integrin
           β1
    • Abstract: Publication date: Available online 25 February 2020Source: Archives of Medical ResearchAuthor(s): Yu Jiang, Yuju Luo
       
  • Infiltrating Macrophages Induced Stem-cell-like Features Through
           PI3K/AKT/GSK3β Signaling to Promote Neurofibroma Growth
    • Abstract: Publication date: Available online 25 February 2020Source: Archives of Medical ResearchAuthor(s): Jing Jia, Haibao Zhang, Hongke Zhang, Wenbo Liu, Maoguo Shu
       
  • Captopril Attenuates the Upregulated Connexin 43 Expression in Artery
           Calcification
    • Abstract: Publication date: Available online 25 February 2020Source: Archives of Medical ResearchAuthor(s): Mincai Li, Zexia Wang, Juan Shao, Suqin Li, Hongli Xia, Liangzhu Yu, Zhenwu Hu
       
  • Effect of L-Carnitine Supplementation on Liver Enzymes: A Systematic
           Review and Meta-Analysis of Randomized Controlled Trials
    • Abstract: Publication date: January 2020Source: Archives of Medical Research, Volume 51, Issue 1Author(s): Moein Askarpour, Kurosh Djafarian, Ehsan Ghaedi, Omid Sadeghi, Ali Sheikhi, Sakineh Shab-Bidar
       
  • Evaluation of Relationship Between Common Variants in FGF18 Gene and Knee
           Osteoarthritis Susceptibility
    • Abstract: Publication date: January 2020Source: Archives of Medical Research, Volume 51, Issue 1Author(s): Tianyun Zhao, Junji Zhao, Chi Ma, Jie Wei, Bo Wei, Jibin Liu
       
  • Cord Blood Banking and Transplantation at the Mexican Institute of Social
           Security: Thirteen Years of Experience
    • Abstract: Publication date: January 2020Source: Archives of Medical Research, Volume 51, Issue 1Author(s): Ángel Guerra-Márquez, Karina Peñaflor, Hector Mayani
       
  • In Vitro Employment of Recombinant Taenia solium Calreticulin as a Novel
           Strategy Against Breast and Ovarian Cancer Stem-like Cells
    • Abstract: Publication date: January 2020Source: Archives of Medical Research, Volume 51, Issue 1Author(s): Alejandro Schcolnik-Cabrera, Mandy Juárez, Bernardo Oldak, Mayra Cruz-Rivera, Ana Flisser, Alfonso Dueñas-González, Vinnitsa Buzoianu-Anguiano, Sandra Orozco-Suarez, Fela Mendlovic
       
  • Prevalence of Post-traumatic Stress Disorder and Depression After the
           September 19th, 2017 Earthquake in Mexico
    • Abstract: Publication date: November 2019Source: Archives of Medical Research, Volume 50, Issue 8Author(s): Jesús Maya-Mondragón, Francisco Raúl Sánchez-Román, Adriana Palma-Zarco, Manuel Aguilar-Soto, Víctor Hugo Borja-Aburto
       
  • Preventing Transphobic Bullying and Promoting Inclusive Educational
           Environments: Literature Review and Implementing Recommendations
    • Abstract: Publication date: November 2019Source: Archives of Medical Research, Volume 50, Issue 8Author(s): Tecelli Domínguez-Martínez, Rebeca Robles
       
  • Formononetin: Novel Deal for Androgenetic Alopecia
    • Abstract: Publication date: January 2020Source: Archives of Medical Research, Volume 51, Issue 1Author(s): Amr Ahmed El-Arabey, Mohnad Abdalla
       
  • TSGA10 Over Expression Decreases Metastasic and Metabolic Activity by
           Inhibiting HIF-1 in Breast Cancer Cells
    • Abstract: Publication date: January 2020Source: Archives of Medical Research, Volume 51, Issue 1Author(s): Mozhgan Jahani, Mohsen Shahlaei, Fatemeh Norooznezhad, Sayyed Shahram Miraghaee, Leila Hosseinzadeh, Narges Moasefi, Reza Khodarahmi, Alireza Farokhi, Azadeh Mahnam, Kamran MansouriBackground and AimsHIF-1 is an important factor that play critical roles in metabolic and metastasis activity of cancer cells. HIF-1 activity can have regulated by TSGA10. Although decreased metastatic activity of cancer cells through TSGA10 inhibitory effect on HIF-1 have already been demonstrated, changes in cancer metabolism and its impact on metastasis in breast cancer is still not determined. So, we aimed to investigate TSGA10 overexpression effect on breast cancer metabolism as well as metastasis.MethodsTSGA10 vector was designed and stable transfected into MCF-7 cells. The efficiency of transfection was assessed by Real-time PCR and western blot. After HIF-1 induction at high and low glucose conditions, cell proliferation, cell cycle profile, metabolic and metastasis activity of cells were assessed. Furthermore, biomarker expressions of ER, PR, HER2, Ki67 and E-cadherin in cancer cells were measured.ResultsOur results showed decrease of cell proliferation and cell cycle arrest in G2/M phase. Reduce expression of GLUT1, lactate production and reactive oxygen species (ROS) below their basal level indicated decreased metabolic activity. Furthermore, metastatic activity reduction was shown by decrease expression of different involve genes in metastasis, protelytic activity of MMOLP-2/9, carbonic anhydrase (CA) IX activity and increase of wound closure. Moreover, except for E-cadherin, expression of ER, PR, HER2 and Ki67 was declined in cells.ConclusionOur findings indicated that TSGA10 overexpression could decrease the metastatic and metabolic activity of cancer cells through its inhibitory effect on HIF-1 activity. Therefore, TSGA10 could be considered in the research for therapeutic candidates in cancer.
       
  • p-Coumaric Acid Mitigates Doxorubicin-Induced Nephrotoxicity Through
           Suppression of Oxidative Stress, Inflammation and Apoptosis
    • Abstract: Publication date: January 2020Source: Archives of Medical Research, Volume 51, Issue 1Author(s): Zeinab Rafiee, Maasoumeh Zare Moaiedi, Armita Valizade Gorji, Esrafil MansouriBackground and AimsP-Coumaric acid (PCA) is one the compound that has free radical scavenging effects. This study investigates the protective effect of PCA on tissue damage in DOX-induced nephrotoxicity.MethodsThirty two Wistar rats were divided into control, PCA, DOX (15 mg/kg, i.p.) and DOX plus PCA (100 mg/kg, orally) groups. DOX-induced nephrotoxicity was indicated by marked increase in blood urea nitrogen (BUN) and serum creatinine (Cr) compared to controls. DOX group also showed elevations in lipid peroxidation and reductions in enzyme activities of superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT). Expression of renal inflammatory cytokines including tumor necrosis factor alpha (TNF-α) and interleukin-1 beta (IL-1β) and apoptosis were also elevated in the DOX group.ResultsPCA significantly reversed, nephrotoxicity induced by DOX via lowering BUN, serum Cr and improving histopathological scores as compared to the DOX group. PCA also decreased lipid peroxidation, increased activities of GPx, SOD and CAT, to levels relatively comparable to control. Significant reductions in expression of TNF-α, IL-1β and apoptosis were also observed following Co-administration of PCA relative to the DOX group.ConclusionsResults describe a protective effect of PCA against DOX-induced nephrotoxicity. This effect is likely facilitated through inhibition of oxidative stress, inflammation and apoptosis.
       
  • Indoxyl Sulfate Contributes to Uremic Sarcopenia by Inducing Apoptosis in
           Myoblasts
    • Abstract: Publication date: January 2020Source: Archives of Medical Research, Volume 51, Issue 1Author(s): Gabriela Gomes Cardoso Rodrigues, Humberto Dellê, Rodrigo Barbosa Oliveira Brito, Vinícius Oliveira Cardoso, Kristianne Porta Santos Fernandes, Raquel Agnelli Mesquita-Ferrari, Regiane Stafim Cunha, Andréa Emilia Marques Stinghen, Maria Aparecida Dalboni, Fellype Carvalho BarretoObjetiveUremic sarcopenia is a complication of chronic kidney disease, particularly in its later stages, which leads to musculoskeletal disability. Uremic toxins have been linked to the pathogenesis of several manifestations of uremic syndrome. We sought to investigate whether indoxyl sulphate (IS), a protein-bound uremic toxin, is implicated in the development of uremic sarcopenia.Material and MethodsMyoblasts were exposed to IS at normal (0.6 mg/L, IS0.6), uremic (53 mg/L, IS53) or maximum uremic (236 mg/L, IS236) concentrations for 24, 48 and 72 h. Cell viability was evaluated by MTT assay and by 7-aminoactinomycin D staining. ROS generation and apoptosis were evaluated by flow cytometry. MyoD and myogenin mRNA expression was evaluated by qRT-PCR and myosin heavy chain expression by immunocytochemistry.ResultsMyoblast viability was reduced by IS236 in a time-dependent pattern (p
       
  • Association of Genetic Variants of Dopamine and Serotonin Receptors with
           Schizophrenia
    • Abstract: Publication date: January 2020Source: Archives of Medical Research, Volume 51, Issue 1Author(s): Roksana Zakharyan, Hovsep Ghazaryan, Lenka Kocourkova, Andranik Chavushyan, Artur Mkrtchyan, Veronika Zizkova, Arsen Arakelyan, Martin PetrekBackgroundSeveral studies indicated that antipsychotic treatment response and side effect manifestation can be different due to inter-individual variability in genetic variations.Aim of the studyHere we perform a case-control study to explore a potential association between schizophrenia and variants within the antipsychotic drug molecular targets (DRD1, DRD2, DRD3, HTR2A, HTR6) and metabolizing enzymes (CYP2D6, COMT) genes in Armenian population including also analysis of their possible relationship with disease clinical symptoms.MethodsA total of 18 SNPs was studied in patients with schizophrenia (n = 78) and healthy control subjects (n = 77) using MassARRAY genotyping. Results: We found that two studied genetic variants, namely DRD2 rs4436578*C and HTR2A rs6314*A are underrepresented in the group of patients compared to healthy subjects. After the correction for multiple testing, the rs4436578*C variant remained significant while the rs6314*A reported borderline significance. No significant differences in minor allele frequencies for other studied variants were identified. Also, a relationship between the genotypes and age of onset as well as disease duration has been detected.ConclusionsThe DRD2 rs4436578*C genetic variant might have protective role against schizophrenia, at least in Armenians.
       
  • Pharmacological Activity of Quercetin and 5 caffeoylquinic Acid Oral
           Intake in Male Balb/c Mice with Lung Adenocarcinoma
    • Abstract: Publication date: January 2020Source: Archives of Medical Research, Volume 51, Issue 1Author(s): Claudia Albrecht, María Cecilia Cittadini, Elio Andrés SoriaBackgroundLung adenocarcinoma (LAC) is a major worldwide cause of death by cancer, it shows high aggressiveness, functional decline, systemic compromise and severe cachexia, which might be counteracted by dietary redox-active phytochemicals. Therefore, our aim was to establish the anticancer effects of the oral intake of quercetin and 5 caffeoylquinic acid.MethodsLAC-1-bearing male Balb/c mice received quercetin (0–25 μg/kg/d) and 5 caffeoylquinic acid (0–120 μg/kg/d) for three weeks, with different organic and biochemical variables being then compared with ANOVA and the Fisher Test (p 1.15 fold tumour hydroperoxides and lipoperoxides, whereas 5 caffeoylquinic acid induced only lipoperoxides. Although both phytochemicals reduced 1.15 fold hepatic and renal weights. Although these phytochemicals did not modify telencephalic interleukin 6 production, quercetin augmented 2.51 fold interleukin 6 in the diencephalon, whereas 5 caffeoylquinic acid decreased it 0.43 fold.ConclusionsQuercetin delayed lung adenocarcinoma appearance and increased the non-neoplastic body weight gain in mice with tumour oxidative stress, without brain interleukin 6 participation. 5 caffeoylquinic acid showed similar effects, although they were weaker. Additionally, quercetin acted as a hepatic and renal antioxidant, whereas 5 caffeoylquinic acid only exerted this effect in the kidney. Therefore, safe oral doses of this flavonoid are promissory to modulate lung cancer progression, with further studies being encouraged.
       
  • 50 years of Archives of Medical Research. A Bibliometric
           Analysis
    • Abstract: Publication date: January 2020Source: Archives of Medical Research, Volume 51, Issue 1Author(s): Ana Carolina Sepúlveda-Vildósola, Natxieli Alexandra Fuentes-Morales, Carolina Barrera-Cruz
       
  • Importance of Genotyping Cystic Echinococcosis in Humans From Mexico
    • Abstract: Publication date: January 2020Source: Archives of Medical Research, Volume 51, Issue 1Author(s): Armando Totomoch-Serra, Carlos Manterola
       
  • Social Violence Increases the Risk of Suicidal Ideation Among
           Undergraduate Medical Students
    • Abstract: Publication date: November 2019Source: Archives of Medical Research, Volume 50, Issue 8Author(s): Beatriz Escobar-Padilla, Horacio Márquez-González, Carolina Consejo y Chapela, Ana Cecilia López-Sepúlveda, Ana Carolina Sepúlveda VildósolaBackgroundDepression is highly prevalent worldwide, and may have fatal consequences. Violence is associated to psychopathology and has exponentially increased in some areas of Mexico. Healthcare professionals are vulnerable to increased anxiety, depression, suicide and lately, to violence by organized crime. The aim of the study was to determine the prevalence of anxiety/depression/suicidal ideation and the weight of social violence as a risk factor.MethodsCross sectional study in three generations of undergraduate medical students at entry to internship year in our institution. All students voluntarily agreed to participate. All of them answered Beck and HAM-A. Two generations also responded Plutchik suicidal risk inventory. Sex, type of university and degree of violence in their geographic areas were also recorded. Prevalence rates were calculated for each outcome. χ2 tests and odds ratio (OR) for bivariate analysis, and Mantel-Hanezel to adjust according to level of violence.ResultsAll of the eligible students responded the anxiety and inventories (n = 8,858), and 6,451 also responded the suicide risk test. Overall, 37.2% displayed severe anxiety, 14.9% moderate/severe depression and 8.5% suicidal ideation. Female sex and private university increased the risk for anxiety and depression. High violence, severe anxiety or depression increased the risk for suicidal ideation. Adjusted by violence zone, female sex, being single and the coexistence of depression were associated with a higher risk for suicidal ideation.ConclusionsAnxiety, depression and suicidal ideation are highly prevalent among premedical interns in Mexico. Living in highly violent areas significantly increases the risk for anxiety/depression/suicidal ideation.
       
  • WHO-mhGAP Training in Mexico: Increasing Knowledge and Readiness for the
           Identification and Management of Depression and Suicide Risk in Primary
           Care
    • Abstract: Publication date: November 2019Source: Archives of Medical Research, Volume 50, Issue 8Author(s): Rebeca Robles, Pilar Lopez-Garcia, Marta Miret, Maria Cabello, Ester Cisneros, Alfredo Rizo, Jose Luis Ayuso-Mateos, María Elena Medina-MoraBackgoundIn order to reduce the treatment gap of mental disorders, the World Health Organization (WHO) has proposed the mhGAP guidelines to be implemented globally.Aim of the studyTo examine the effectivity of a training course based on the WHO-mhGAP guidelines to increase knowledge and readiness for identification and management of depression and suicide risk in primary care (PC) in Mexico.MethodsPC clinicians were invited to participate in a traning course; before and after it, all completed an evaluation of knowledge of mhGAP and depression (0-10 points), and self-efficacy in suicide risk management (0–40 points), and were classified according to Prochaska and Diclemente transtheorical model in their particular stage of readiness for identification and management of these conditions.ResultsThe sample included 60 health professionals. Before training, clinicians had adequate knowledge of depression and its treatment (8.1 ± 1.66), but not on the mhGAP model and/or suicide risk management, which increased by the end of training (mhGAPpre:7.91 ± 2.19 vs. mhGAPpost:8.77 ± 1.34, p = 0.01; SuicidePRE:29.16 ± 9.35 vs. SuicidePOST:39.24 ± 6.83, p = 0.0001). Before training, most clinicians were at the contemplation stage (42.6% vs. 37.7% at the action and 19.7% at the precontemplation stage). By the end of the training, a decrease in the number of clinicians at both the contemplation and precontemplation stages (to 36.1% and to zero, respectively) and a significant increase of clinicians at the action stage (to 63.9%) was observed. Conclusions: A training course based on the WHO-mhGAP could be an effective tool for increasing PC clinicians’ willingness to implement mental health services.
       
  • A Clinically Useful, Globally Applicable, Science-based Classification
    • Abstract: Publication date: November 2019Source: Archives of Medical Research, Volume 50, Issue 8Author(s): Geoffrey M. Reed, María Elena Medina-Mora
       
  • Field Testing of ICD-11 Proposals for Female Sexual Dysfunctions in India:
           Cognitive Interviews with Patients
    • Abstract: Publication date: November 2019Source: Archives of Medical Research, Volume 50, Issue 8Author(s): Pratap Sharan, Shivani Purnima, Ravindra Rao, Swati Kedia, Brigitte Khoury, Geoffrey M. ReedBackgroundWomen's experiences of female sexual difficulties are shaped by cultural expectations.Aim of the studyTo investigate the cultural validity and clinical utility of the classification of female sexual dysfunctions (FSD) in the International Classification of Diseases - 11th Revision (ICD-11) among Indian Women.MethodsA purposive sample of 22 married women with probable sexual problems underwent cognitive interviews that were conducted using a semi-structured guide. The interviews were transcribed and analyzed qualitatively to help establish the content and cultural validity of the ICD-11 classification of FSD.ResultsMost participants had limited knowledge of the sexual act, felt unskilled in sex, and were led by their husbands in sexual matters. Many participants reported problems related to sexual dysfunction and sexual pain-penetration. Many participants with sexual pain–penetration issues and some with low sexual desire considered these symptoms to be problematic; however, this was rarely the case with the absence or lack of sexual arousal and orgasm. The application of the ‘independent focus of clinical attention’ requirement for diagnosis reduced cases by half for Hypoactive Sexual Desire Disorder (HSDD) and almost eliminated all cases of Female Sexual Arousal Dysfunction (FSAD) and Anorgasmia. Hence, this requirement was moved from essential (required) features to ‘additional features’ of the final ICD-11 sexual dysfunction guidelines.ConclusionAdvancement toward a more precise nomenclature and classification system of FSD will facilitate better diagnosis which will ultimately lead to improved care for women with sexual dysfunction.
       
  • Opioid Crisis Along Mexico's Northern Border: Treatment Needs Mexican
           Opioid Crisis
    • Abstract: Publication date: November 2019Source: Archives of Medical Research, Volume 50, Issue 8Author(s): Clara Fleiz, Jorge Villatoro, Mario Dominguez, Marycarmen Bustos, María Elena Medina-MoraBackgroundHeroin production for external markets and low rates of use in Mexico have had a long history. A recent shift toward an increase in use and related problems calls for the evaluation of treatment needs in order to draw recommendations for policies.MethodsThe objectives were to identify predictors of choice of treatment and barriers to care among persons that had been with no treatment. The study included a convenience sample of 600 face-to-face interviews of people 18 years of age and older and a rapid HIV and HCV tests in three cities on Mexico's Northern Border: Ciudad Juárez, San Luis Río Colorado and Tijuana. The choice of treatment (methadone, other pubic or private treatments with no experience with methadone maintenance and only self-help or religious care), was analyzed though a multiple logistic multimodal regression analysis. Informed consents to be interviewed and for HIC and HIV were signed by interviewers.ResultsThe majority of persons interviewed were males (89.7%) with an average age of 40. Having emigrated to the United States and a greater length of heroin use predicted seeking methadone treatment versus public or private treatment or informal care. The most important barriers to care were lack of information and stigma. HIC, HIV and other infectious and chronic diseases including depression were often unattended.ConclusionsThere is a need to reform treatment policies in order to cover this w emerging and demanding problem.
       
  • Reliability and Clinical Utility of ICD-11 Diagnostic Guidelines for
           Severe Mental Disorders in Nigeria
    • Abstract: Publication date: November 2019Source: Archives of Medical Research, Volume 50, Issue 8Author(s): Lucky Onofa, Mayokun Odunleye, Lola Kola, Oye GurejeBackgroundAn essential foundation for global mental health is the development of reliable, clinically useful and globally applicable diagnostic classification of mental disorders.AimThis study is aimed at assessing the inter-rater reliability and clinical utility of the proposed diagnostic guidelines for severe mental disorders in the eleventh edition of the International Classification of Diseases and Related Health Problems (ICD-11) in Nigeria.MethodThe study was conducted in Nigeria at 2 mental health facilities as part of a 13 country project coordinated by the World Health Organization. Following training, 32 clinician raters assessed the reliability and clinical utility of the proposed diagnostic guidelines for schizophrenia and other primary psychotic disorders, mood disorders, anxiety and fear-related disorders, and disorders specifically associated with stress. Using SPSS version 21, analysis of data was conducted at the Data Coordinating Center (DCC), Columbia University.ResultsFor reliability, estimates of intraclass κ coefficients for diagnoses ranged between 0.71 (Schizoaffective disorder) and 0.93 (Schizophrenia). In ratings of the clinical utility, the guidelines were perceived as easy to use, corresponding accurately to patients’ presentations (i.e. having satisfactory goodness-of-fit), clearly understandable, and as providing useful guidance on distinguishing a disorder from normality and from other mental disorders.ConclusionOverall, the reliability of the diagnostic guidelines was good in Nigeria, ranging from substantial to almost perfect. Utility ratings were generally satisfactory. The results support the suitability of the ICD-11 diagnostic guidelines for implementation at a worldwide level.
       
  • Drug-related Virtual Reality Cue Reactivity is Associated with Gamma
           Activity in Reward and Executive Control Circuit in Methamphetamine
           Use Disorders
    • Abstract: Publication date: November 2019Source: Archives of Medical Research, Volume 50, Issue 8Author(s): Haoye Tan, Tianzhen Chen, Jiang Du, Runji Li, Haifeng Jiang, Cheng-long Deng, Weidong Song, Ding Xu, Min ZhaoBackgroundAccumulated studies in substance use disorders indicated that the mesocorticolimbic reward circuit and executive control circuit played interactive roles in the cue-reactivity and gamma oscillatory in the cortex, as well as autonomic nervous activity was associated with it.Aim of the studyThis study aimed to explore the mechanism of processing drug-related cues.MethodsSixty methamphetamine users were recruited and exposed to the drug-related virtual reality (VR) environments. Self-reported craving was assessed and skin conductance level (SCL) and heart rate variability were used to measure the autonomic nervous reactivity. With source estimation, gamma current density was used to measure the activity of medial prefrontal cortex/orbitofrontal cortex (MPFC/OFC) and dorsolateral prefrontal cortex (DLPFC) which are responsible for the mesocorticolimbic reward circuit and the executive control circuit.ResultsThe VR drug-related cue induced an increased craving and SCL compared with the neutral condition. Gamma activity in MPFC/OFC and right DLPFC were decreased after cue exposure and predicted the SCL changes. However, no association was found between self-reported craving and electrophysiological response.ConclusionsCue-reactivity in cortex and ANS, as well as their association, were observed in this study. Cue-induced electrophysiological responses were related to gamma activity in the mesocorticolimbic reward circuit and the executive control circuit.
       
  • Endocannabinoids as Therapeutic Targets
    • Abstract: Publication date: November 2019Source: Archives of Medical Research, Volume 50, Issue 8Author(s): Oscar Prospéro-García, Alejandra E. Ruiz Contreras, Alette Ortega Gómez, Andrea Herrera-Solís, Mónica Méndez-Díaz, Grupo de Neurociencias de la Universidad Nacional Autónoma de MéxicoMost of the drugs of abuse affect the brain by interacting with naturally expressed molecular receptors. Marihuana affects a series of receptors including cannabinoid receptor 1 (CB1R) and CB2R, among others. Endogenous molecules with cannabinoid activity interact with these receptors naturally. Receptors, ligands, synthesizing and degrading enzymes, as well as transporters, have been described. This endocannabinoid system modulates behaviors and physiological processes, i.e. food intake, the sleep-waking cycle, learning and memory, motivation, and pain perception, among others. The rather broad distribution of endocannabinoids in the brain explains the different effects marihuana induces in its users. However, this very same anatomical and physiological distribution makes this system a useful target for therapeutic endeavors. In this review, we briefly discuss the potential of small molecules that target the endocannabinoids as therapeutic tools to improve behaviors and treat illnesses. We believe that under medical supervision, endocannabinoid targets offer new advantages for patients for controlling multiple medical disorders.
       
  • Professional Adversities and Protective Factors Associated with Suicidal
           Ideation in Mexican Psychiatrists
    • Abstract: Publication date: November 2019Source: Archives of Medical Research, Volume 50, Issue 8Author(s): Ana Fresán, María Yoldi-Negrete, Rebeca Robles-García, Carlos-Alfonso Tovilla-Zárate, Aldo Suárez-MendozaBackgroundPsychiatrists may be at an increased risk of suicide, since they encounter stressful factors in their everyday activities in addition to the sociodemographic factors for suicidal ideation reported for Mexican population.Aim of the studyTo determine whether experiences inherent to the profession were related to the self-report of suicidal ideation among Mexican psychiatrists or could be attributed to factors previously reported in the general population (age, marital status, presence of a mental disorder and not having received specialized treatment).MethodsThis was a cross-sectional retrospective study with 288 psychiatrists from Mexico who participated through an online survey where current working activities, self-reported mental health conditions (major depression, anxiety, burnout and suicidal ideation) and professional adversities (assaults, lawsuits, patients with suicidal ideation or who had committed suicide, perceived discrimination and social support) throughout the professional lifespan were evaluated.ResultsTwenty-two psychiatrists (7.6%) reported having had suicidal ideation at some point in their training in psychiatry or their professional lives as psychiatrists. Depression and burnout were the most important predictors for suicidal ideation while greater satisfaction with social support was the most important protector, followed by being married/living together and having other physicians in the family.ConclusionsPsychiatrist represent a risk population for suicidal ideation. As such, detection and attention are essential. Psychiatrists need to be encouraged to pursue healthy, lasting interpersonal relationships and seek professional help when required.
       
  • Dopaminergic Hyperactivity in Neurological Patients with Delirium
    • Abstract: Publication date: November 2019Source: Archives of Medical Research, Volume 50, Issue 8Author(s): Jesús Ramírez-Bermúdez, Ivan Perez-Neri, Sergio Montes, Francisco Nente, Marisol Ramirez-Abascal, Roger Carrillo-Mezo, Rodrigo Pérez-Esparza, Jose Luis Soto-Hernandez, Mariana Espinola-Nadurille, Leo Bayliss, Jose De Jesus Flores Rivera, Camilo RiosBackgroundDelirium has important etiological, prognostic, and therapeutic implications. The study of neurochemical markers in this condition is relevant to the understanding of its pathophysiology. The assessment of the dopamine system is particularly relevant, as dopamine antagonists are the most used drugs in delirium.AimTo analyze neurotransmission markers in patients with delirium, focusing in the dopamine metabolite, homovanillic acid.MethodsA case-control study was performed at the National Institute of Neurology and Neurosurgery, Mexico, including hospitalized patients in which lumbar puncture was obtained for diagnostic purposes. Cases were selected if they fulfilled DSM-5 criteria for delirium. Age-paired controls were patients in which delirium was ruled out, selected at the same clinical scenario, during the same period. Neurological and systemic diagnoses were registered. Delirium was assessed using the DRS-98-R instrument. The dopamine metabolite, homovanillic acid (HVA), was measured by means of high-performance liquid chromatography. Other neurotransmission markers were also measured (5-hydroxyindoleacetic acid, glutamate, aspartate, GABA, glycine, arginine, citrulline, nitrites, and nitrates). A logistic regression model was used to determine pathogenic factors associated with the presence of delirium.Results68 neurological patients with delirium and 68 patients without delirium were included. Higher homovanillic acid levels in cerebrospinal fluid were significantly associated with delirium. This result was significant after a subanalysis in patients without exposure to antipsychotics. Male gender and autoimmune limbic encephalitis were also associated with the presence of delirium.ConclusionsIn hospitalized neurological patients, dopaminergic hyperactivity and autoimmune limbic encephalitis are pathogenic factors associated with the presence of delirium.
       
  • Anxiety and Fear-Related Disorders in the ICD-11: Results from a
           Global Case-controlled Field Study
    • Abstract: Publication date: November 2019Source: Archives of Medical Research, Volume 50, Issue 8Author(s): Tahilia J. Rebello, Jared W. Keeley, Cary S. Kogan, Pratap Sharan, Chihiro Matsumoto, Maya Kuligyna, Tecelli Domínguez-Martínez, Anne-Claire Stona, Jean Grenier, Jingjing Huang, Na Zhong, Dan J. Stein, Paul Emmelkamp, Subho Chakrabarti, Howard F. Andrews, Geoffrey M. ReedBackgroundThis article reports the results of one of a series of global field studies implemented by the World Health Organization (WHO) to evaluate the accuracy, clinical utility, and global applicability of the new diagnostic guidelines for Mental, Behavioural and Neurological Disorders included in the next version of WHO's International Classification of Diseases (ICD-11).Aims of the studyThe purpose of this study was to compare the diagnostic accuracy and clinical utility ratings of global clinicians implementing the ICD-11 diagnostic guidelines for Anxiety and Fear-Related Disorders, relative to those applying ICD-10 guidelines. The study also aimed to identify elements of the guidelines that required further refinement or clarification.Methods1840 global mental health professionals registered with WHO's Global Clinical Practice Network completed the study in one of six study languages. Participants were randomly assigned to apply either the ICD-11 or ICD-10 guidelines to diagnose standardized case vignettes, and to rate the clinical utility of their assigned guidelines.ResultsICD-11's diagnostic accuracy and clinical utility were equivalent or superior to that of ICD-10. Global clinicians were significantly more accurate in diagnosing Generalized Anxiety Disorder, Specific Phobia and adult cases of Separation Anxiety Disorder when using ICD-11 and provided high clinical utility ratings for these disorders. Clinicians also found the ICD-11 guidelines easy to use, clear, and a good fit to patients they see in their clinical practice. However, clinicians had difficulty with distinguishing the boundary between disorder and normality for subthreshold cases of anxiety, and also with applying the new ICD-11 guidelines on panic attacks.ConclusionsThe new diagnostic guidelines for Anxiety Disorders in ICD-11 can be applied in an acceptably consistent manner by global clinicians and perform as well or better than the previous guidelines for ICD-10. Study findings also helped identify aspects of the ICD-11 guidelines that required refinement prior to their publication and areas that should be emphasized in training programs.
       
 
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