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DERMATOLOGY AND VENEREOLOGY (163 journals)                     

Showing 1 - 163 of 163 Journals sorted alphabetically
Acta Dermato-Venereologica     Open Access   (Followers: 12)
Acta Dermatovenerologica Croatica     Open Access   (Followers: 1)
Actas Dermo-Sifiliograficas     Full-text available via subscription   (Followers: 3)
Actas Dermo-Sifiliográficas (English Edition)     Full-text available via subscription   (Followers: 2)
Advances in Dermatology     Full-text available via subscription   (Followers: 16)
Advances in Skin & Wound Care     Hybrid Journal   (Followers: 27)
African Journal of AIDS Research     Hybrid Journal   (Followers: 8)
AIDS     Hybrid Journal   (Followers: 23)
AIDS Care: Psychological and Socio-medical Aspects of AIDS/HIV     Hybrid Journal   (Followers: 9)
AIDS Patient Care and STDs     Hybrid Journal   (Followers: 3)
AIDS Research and Human Retroviruses     Hybrid Journal   (Followers: 9)
AIDS Research and Therapy     Open Access   (Followers: 14)
AIDS Research and Treatment     Open Access   (Followers: 2)
Aktuelle Dermatologie     Hybrid Journal   (Followers: 7)
Allergo Journal     Full-text available via subscription   (Followers: 1)
American Journal of Clinical Dermatology     Full-text available via subscription   (Followers: 26)
American Journal of Dermatopathology     Hybrid Journal   (Followers: 17)
Anais Brasileiros de Dermatologia     Open Access   (Followers: 2)
Anaplastology     Open Access  
Annales de Dermatologie et de Vénéréologie     Full-text available via subscription  
Archives de Pédiatrie     Full-text available via subscription  
Archives de sciences sociales des religions     Open Access   (Followers: 1)
Archives des Maladies du Coeur et des Vaisseaux - Pratique     Hybrid Journal  
Archives of Dermatological Research     Hybrid Journal   (Followers: 7)
Archives of Gerontology and Geriatrics     Hybrid Journal   (Followers: 13)
Archives of Industrial Hygiene and Toxicology     Open Access   (Followers: 8)
Archives of Medical Research     Hybrid Journal   (Followers: 3)
Archives of Physical Medicine and Rehabilitation     Hybrid Journal   (Followers: 55)
Archivio di Ortopedia e Reumatologia     Hybrid Journal  
Asian Journal of Dermatology     Open Access   (Followers: 2)
ästhetische dermatologie & kosmetologie     Full-text available via subscription  
Australasian Journal of Dermatology     Hybrid Journal   (Followers: 8)
Berkala Ilmu Kesehatan Kulit dan Kelamin / Periodical of Dermatology and Venereology     Open Access  
Biomedical Dermatology     Open Access  
BMC Dermatology     Open Access   (Followers: 13)
BMJ Sexual & Reproductive Health     Hybrid Journal   (Followers: 2)
British Journal of Dermatology     Hybrid Journal   (Followers: 55)
Case Reports in Dermatological Medicine     Open Access   (Followers: 2)
Case Reports in Dermatology     Open Access   (Followers: 9)
Clinical and Experimental Dermatology     Hybrid Journal   (Followers: 14)
Clinical Dermatology Review     Open Access   (Followers: 5)
Clinical Skin Cancer     Full-text available via subscription  
Clinical, Cosmetic and Investigational Dermatology     Open Access   (Followers: 9)
Clinics in Dermatology     Hybrid Journal   (Followers: 15)
Contact Dermatitis     Hybrid Journal   (Followers: 7)
Cosmetics     Open Access   (Followers: 5)
Current Dermatology Reports     Hybrid Journal   (Followers: 7)
Current Fungal Infection Reports     Hybrid Journal   (Followers: 5)
Current HIV Research     Hybrid Journal   (Followers: 7)
Current HIV/AIDS Reports     Hybrid Journal   (Followers: 6)
Current Sexual Health Reports     Hybrid Journal   (Followers: 3)
Cutaneous and Ocular Toxicology     Hybrid Journal   (Followers: 10)
Der Hautarzt     Hybrid Journal   (Followers: 2)
Dermatitis     Hybrid Journal   (Followers: 1)
Dermato-Endocrinology     Open Access   (Followers: 2)
Dermatología Venezolana     Open Access  
Dermatologic Clinics     Full-text available via subscription   (Followers: 4)
Dermatologic Reviews     Hybrid Journal  
Dermatologic Surgery     Hybrid Journal   (Followers: 8)
Dermatologic Therapy     Hybrid Journal   (Followers: 2)
Dermatologica Sinica     Open Access  
Dermatological Nursing     Full-text available via subscription   (Followers: 1)
Dermatology     Full-text available via subscription   (Followers: 20)
Dermatology and Cosmetic     Open Access   (Followers: 7)
Dermatology and Therapy     Open Access   (Followers: 4)
Dermatology Online Journal     Open Access   (Followers: 1)
Dermatology Reports     Open Access   (Followers: 3)
Dermatology Research and Practice     Open Access   (Followers: 4)
Dermatology Times     Free  
Dermatopathology     Open Access   (Followers: 3)
Egyptian Journal of Dermatology and Venerology     Open Access   (Followers: 1)
EMC - Cosmetologia Medica e Medicina degli Inestetismi Cutanei     Full-text available via subscription  
EMC - Dermatología     Full-text available via subscription   (Followers: 1)
European Journal of Dermatology     Hybrid Journal   (Followers: 15)
Experimental Dermatology     Hybrid Journal   (Followers: 10)
Expert Review of Dermatology     Hybrid Journal   (Followers: 14)
Forum Dermatologicum     Hybrid Journal  
Graefe's Archive for Clinical and Experimental Ophthalmology     Hybrid Journal   (Followers: 8)
Güncel Dermatoloji Dergisi     Open Access  
HautinForm     Full-text available via subscription  
hautnah     Hybrid Journal  
hautnah dermatologie     Hybrid Journal  
HIV & AIDS Review     Full-text available via subscription   (Followers: 13)
HIV Clinical Trials     Hybrid Journal   (Followers: 5)
HIV Medicine     Hybrid Journal   (Followers: 3)
Indian Dermatology Online Journal     Open Access   (Followers: 3)
Indian Journal of Dermatology     Open Access   (Followers: 2)
Indian Journal of Dermatology, Venereology and Leprology     Open Access   (Followers: 4)
Indian Journal of Dermatopathology and Diagnostic Dermatology     Open Access  
Indian Journal of Drugs in Dermatology     Open Access   (Followers: 1)
Indian Journal of Paediatric Dermatology     Open Access   (Followers: 2)
Indian Journal of Sexually Transmitted Diseases and AIDS     Open Access   (Followers: 2)
International Archives of Medicine     Open Access   (Followers: 3)
International Journal of Dermatology     Hybrid Journal   (Followers: 15)
International Journal of Research in Dermatology     Open Access   (Followers: 1)
International Journal of STD & AIDS     Hybrid Journal   (Followers: 7)
International Journal of Women's Dermatology     Open Access   (Followers: 1)
International STD Research & Reviews     Open Access   (Followers: 1)
JAAD Case Reports     Open Access   (Followers: 1)
JAIDS : Journal of Acquired Immune Deficiency Syndromes     Hybrid Journal   (Followers: 4)
JAMA Dermatology     Full-text available via subscription   (Followers: 49)
JAMA Facial Plastic Surgery     Full-text available via subscription   (Followers: 10)
JMIR Dermatology     Open Access   (Followers: 1)
Journal of AIDS & Clinical Research     Open Access   (Followers: 3)
Journal of Clinical & Experimental Dermatology Research     Open Access   (Followers: 6)
Journal of Clinical and Investigative Dermatology     Open Access   (Followers: 2)
Journal of Cosmetic Dermatology     Hybrid Journal   (Followers: 9)
Journal of Cosmetics, Dermatological Sciences and Applications     Open Access   (Followers: 7)
Journal of Cutaneous Immunology and Allergy     Open Access  
Journal of Cutaneous Medicine and Surgery     Full-text available via subscription  
Journal of Dermatological Research     Open Access  
Journal of Dermatological Science     Hybrid Journal   (Followers: 2)
Journal of Dermatological Science Supplement     Full-text available via subscription   (Followers: 1)
Journal of Dermatological Treatment     Hybrid Journal   (Followers: 2)
Journal of Dermatology & Dermatologic Surgery     Open Access   (Followers: 1)
Journal of General-Procedural Dermatology & Venereology Indonesia     Open Access  
Journal of HIV/AIDS & Social Services     Hybrid Journal   (Followers: 9)
Journal of Investigative Dermatology     Hybrid Journal   (Followers: 28)
Journal of Investigative Dermatology Symposium Proceedings     Full-text available via subscription  
Journal of Sexual Medicine     Hybrid Journal   (Followers: 6)
Journal of Sexually Transmitted Diseases     Open Access   (Followers: 3)
Journal of Skin and Stem Cell     Open Access   (Followers: 3)
Journal of Skin Cancer     Open Access   (Followers: 3)
Journal of Surgical Dermatology     Open Access   (Followers: 1)
Journal of the American Academy of Dermatology     Full-text available via subscription   (Followers: 37)
Journal of the Dermatology Nurses' Association     Hybrid Journal   (Followers: 2)
Journal of the Egyptian Women’s Dermatologic Society     Partially Free  
Journal of the European Academy of Dermatology and Venereology     Hybrid Journal   (Followers: 15)
Journal of the International AIDS Society     Open Access   (Followers: 10)
Journal of the Saudi Society of Dermatology & Dermatologic Surgery     Open Access   (Followers: 1)
Karger Kompass Dermatologie     Full-text available via subscription  
Karger Kompass Pneumologie     Full-text available via subscription   (Followers: 1)
Langenbeck's Archives of Surgery     Hybrid Journal   (Followers: 4)
Medical and Surgical Dermatology     Hybrid Journal   (Followers: 1)
Medical Mycology     Open Access   (Followers: 4)
Nepal Journal of Dermatology, Venereology & Leprology     Open Access   (Followers: 1)
Neurobehavioral HIV Medicine     Open Access   (Followers: 2)
OA Dermatology     Open Access   (Followers: 1)
Open AIDS Journal     Open Access  
Open Dermatology Journal     Open Access  
Perspectives On Sexual and Reproductive Health     Hybrid Journal   (Followers: 7)
Pigment International     Open Access   (Followers: 1)
Psoriasis : Targets and Therapy     Open Access   (Followers: 3)
Revista Internacional de Ciencias Podológicas     Open Access  
SAHARA : Journal of Social Aspects of HIV / AIDS Research Alliance     Open Access   (Followers: 5)
Scars, Burns & Healing     Open Access  
Serbian Journal of Dermatology and Venereology     Open Access   (Followers: 1)
Sex Education: Sexuality, Society and Learning     Hybrid Journal   (Followers: 5)
Sexual & Reproductive Healthcare     Hybrid Journal   (Followers: 3)
Sexual Health     Hybrid Journal   (Followers: 4)
Sexually Transmitted Diseases     Hybrid Journal   (Followers: 6)
Sexually Transmitted Infections     Hybrid Journal   (Followers: 6)
Skin Appendage Disorders     Full-text available via subscription   (Followers: 1)
Skin Pharmacology and Physiology     Full-text available via subscription   (Followers: 7)
Skin Research and Technology     Hybrid Journal   (Followers: 7)
Southern African Journal of HIV Medicine     Open Access   (Followers: 3)
Sri Lanka Journal of Sexual Health and HIV Medicine     Open Access  
Studies in Gender and Sexuality     Hybrid Journal   (Followers: 21)
Surgical & Cosmetic Dermatology     Open Access   (Followers: 2)
The Journal of Dermatology     Hybrid Journal   (Followers: 5)
The Rose Sheet     Full-text available via subscription   (Followers: 2)
Vestnik dermatologii i venerologii     Open Access  
Veterinary Dermatology     Hybrid Journal   (Followers: 8)


Similar Journals
Journal Cover
Archives of Gerontology and Geriatrics
Journal Prestige (SJR): 1.01
Citation Impact (citeScore): 3
Number of Followers: 13  
  Hybrid Journal Hybrid journal (It can contain Open Access articles)
ISSN (Print) 0167-4943 - ISSN (Online) 1872-6976
Published by Elsevier Homepage  [3206 journals]
  • Adherence to Mediterranean Diet Moderates the Association Between
           Multimorbidity and Depressive Symptoms in Older Adults
    • Abstract: Publication date: Available online 13 February 2020Source: Archives of Gerontology and GeriatricsAuthor(s): Roberto Vicinanza, Francesco Saverio Bersani, Elisa D’Ottavio, Melanie Murphy, Sciaila Bernardini, Flaminia Crisciotti, Alessandro Frizza, Valentina Mazza, Massimo Biondi, Giovanni Troisi, Mauro CacciafestaAbstractAimAdherence to Mediterranean Diet (Med-Diet) has been associated with a lower incidence of chronic diseases and may be associated with lower risk for depression. The aim of the present study was to investigate (i) the association of adherence to Med-Diet with depressive symptoms and multimorbidity in a cohort of geriatric medical outpatients, and (ii) the role of Med-Diet in mediating the association between depressive symptoms and multimorbidity.MethodsA total of 143 geriatric patients (mean age: 73.1 ± 8.35) were included. Adherence to Med-Diet was evaluated using a validated 14-item questionnaire; depressive and cognitive symptoms were assessed through the 15-item Geriatric Depression Scale (GDS) and Mini Mental State Examination (MMSE) respectively; multimorbidity was evaluated using the Cumulative Illness Rating Scale for Geriatrics (CIRSG-SI).ResultsSignificant associations were found between MDQ score, GDS and CIRSG-SI (MDQ score and GDS: r= -0.206, p = 0.014; MDQ score and CIRSG-SI: r= -0.247, p = 0.003; GDS and CIRSG-SI: r = 0.251; p = 0.003). These associations remained significant after adjusting for potential confounding factors. A mediational model analysis showed that the direct effect of CIRSG-SI on GDS was significant (b = 1.330; se = 0.59; p = 0.028) with this effect being counterbalanced by higher MDQ scores (indirect effect of CIRS-G on GDS through MDQ: b = 0.382; se = 0.19; p = 0.048).ConclusionThese findings (i) add to the accumulating evidence that Med-Diet may have a positive impact on mental health in the elderly, and (ii) suggest that Med-Diet may contribute, at least in part, to protect geriatric patients with multimorbidity from the development of depressive symptoms, ultimately promoting healthy aging.
  • Effects of dance intervention on frailty among older adults
    • Abstract: Publication date: Available online 13 February 2020Source: Archives of Gerontology and GeriatricsAuthor(s): Xiangfei Meng, Guichen Li, Guangwei Zhang, Huiru Yin, Yong Jia, Shuo Wang, Binghan Shang, Chunyan Wang, Li ChenAbstractObjectiveThe aims of this study were to examine the effects of dance intervention on frailty in pre-frail and frail older persons.DesignThis is a quasi-experimental, two-group trial.SettingOlder adults living nursing home.ParticipantsParticipants aged ≥ 60 years with low physical activity (mean age was 81.8 years; 71% were female) (N = 66).MethodsParticipants allocated to the dance group attended 40 min dance sessions in a nursing home, three times a week for 12-weeks. Participants allocated to the control group maintained their normal daily activities. Assessments were conducted at baseline, 6 weeks, and 12 weeks by researchers blinded to the allocation. Frailty was measured based on Fried criteria. Estimates of frailty between groups over time were calculated using the generalized estimating equations (GEE) and mixed effects models.ResultsThe prevalence of frailty decreased over time in the dance group compared to the control group (P = 0.002). The mean frailty scores decreased 0.69 at 6 weeks and 1.06 at 12 weeks. Compared to the control group, the prevalence of slowness (p = 0.002), weakness (p = 0.005), and low physical activity (p 
  • A national study on long-term osteoporosis therapy and risk of recurrent
           fractures in patients with hip fracture
    • Abstract: Publication date: Available online 1 February 2020Source: Archives of Gerontology and GeriatricsAuthor(s): Chiao-Lin Hsu, Hsiu-Min Chen, Hong-Jhe Chen, Ming-Yueh Chou, Yu-Chun Wang, Ying-Hsin Hsu, Chih-Kuang Liang, Che-Sheng ChuAbstractObjectiveThe study aimed to evaluate the impact of osteoporosis (OP) medication persistence on subsequent fractures and all-cause mortality in patients with hip fracture.MethodsIn this retrospective cohort study, we included patients aged ≥ 40 years with fragility hip fracture from the Taiwan’s National Health Insurance Research Database. OP medication persistence was categorized as yes (≥ 12 months) or no (< 12 months). A multivariate Cox proportional hazard model was used to evaluate the association between OP medication persistence and recurrent fractures (including hip, vertebral, and upper and lower limb fractures) and all-cause mortality.ResultsA total of 946 patients were included in the study (86.5% of them aged ≥ 65 years) and 210 patients persistently received OP medications. Persistent OP medication use was associated with lower fracture risk (adjusted hazard ratio [aHR] = 0.64; 95% CI = 0.41–0.99; P = .043) in the follow-up period. The strongest predictors for all-cause mortality were age ≥ 80 years (HR = 5.68, 95% CI = 1.36–23.64, P = .017), male sex (HR = 1.55; 95% CI = 1.18-2.03; P = .002), and Charlson Comorbidity Index ≥ 3 (aHR = 1.56; 95% CI = 1.07-2.27; P = .022). Kaplan-Meier curves showed a lower cumulative incidence of recurrent fractures in the persistent group than that in the non-persistent group (P = .028).ConclusionPersistent OP medication use was associated with a lower risk of recurrent fractures but not with mortality in patients with hip fracture.
  • Regular dental visits may prevent severe functional disability: a
           community-based prospective study
    • Abstract: Publication date: Available online 30 January 2020Source: Archives of Gerontology and GeriatricsAuthor(s): Kimiko Tomioka, Norio Kurumatani, Keigo SaekiAbstractBackgroundPrevious studies have shown that regular dental visits can affect the relationship of tooth loss with mortality and functional disability. However, the independent association between regular dental visits and incident functional disability is unclear.MethodsOur study participants were community-dwelling individuals aged ≥65 years, without disability at baseline. The outcome was the level of incident functional disability, as defined in a new certification of the public long-term care insurance. We defined no disability as no certification at follow-up, mild disability as support levels 1-2 and care level 1 (i.e., independent in basic ADL, but requiring some help in daily activities), and severe disability as care levels 2-5 (i.e., dependent in basic ADL). The exposure variable, based on the questionnaire, was regular dental visits at baseline. Covariates included gender, age, socio-economic status, health status, lifestyle habits, physical and mental functioning, and oral health variables. Using multinomial logistic regression, we calculated adjusted odds ratio (aOR) and 95% confidence interval (CI) for mild disability and severe disability, with no disability as a reference category.ResultsAmong 8,877 participants, the 33-month cumulative incidence of mild and severe disability was 6.0% and 1.8%, respectively. After controlling for all covariates, regular dental visits at baseline were significantly associated with a lower risk of incident severe disability (aOR 0.65; 95% CI, 0.46–0.91) but not the incidence of mild disability (aOR 0.96; 95% CI, 0.79–1.17).ConclusionsEncouraging dental visits may contribute to prevention of severe functional disability and extension of healthy life expectancy among community-dwelling older adults.
  • The link between falls, social isolation and loneliness: A systematic
    • Abstract: Publication date: Available online 30 January 2020Source: Archives of Gerontology and GeriatricsAuthor(s): Nicola Petersen, Hans-Helmut König, André HajekAbstractBackgroundThe chances of experiencing a fall among those aged 60 years and older increase as risk factors accumulate. In the last few decades, several studies have identified different risk factors for falls in older people, including the role of social isolation and loneliness. This systematic review provides an overview of published literature that analyzes the bidirectional relation between falls and social isolation or loneliness.Material and methodsTwo databases (PubMed and Europe PMC) were used to search for publications investigating the relationship between falls, social isolation and/or loneliness in older people. Similar articles and references were screened against the inclusion criteria.Results17 studies met the inclusion criteria and were included. Only a few studies assessed the association between falls and social isolation/loneliness among older people. Therefore articles examining the association between falls and living alone status among people aged 60 and older were included as well. In all studies loneliness, social isolation, and living alone were significantly associated with falls in older people.ConclusionsThe findings emphasize the importance of the relationship between falls and social isolation, loneliness and living alone among older people. As there are only a few studies assessing the relationship between falls and loneliness or social isolation, further research in this field should be conducted. In particular, longitudinal studies that utilize standardized measurement instruments should be carried out.
  • Overestimated functional dependency in older patients: can we blame gender
           difference, unneeded assistance or assessment tools'
    • Abstract: Publication date: Available online 29 January 2020Source: Archives of Gerontology and GeriatricsAuthor(s): Doha Rasheedy, Rania Mohammed Abou-HashemAbstractIntroductionThe population is aging in Egypt and hence functional limitation is increasing. Thus finding the best measures for its detection is mandated.ObjectivesThe aim of this study was to assess whether Katz ADL (activities of daily living) and Lawton IADL (instrumental activities of daily living) were suitable measures to represent the functional abilities of older Egyptians of both genders during hospital admission and to determine the dimensionality of both tools.MethodsFunctional status was assessed during hospital admission as a part of the comprehensive geriatric assessment for 786 older patients (aged 60 years and older). 150 of them were randomly interviewed to collect data regarding the difficulty during each task of Katz ADL and Lawton IADL performance, unnecessary and unmet needed assistance, barriers to get needed assistance and the type of care providers.ResultsThe prevalence of ADL and IADL dependency was 61.80% and 85.87 %, respectively. Functional limitation in both scales was found to be significantly associated with increasing age, marital status other than married, cognitive impairment. Both scales showed a bi-dimensional factor structure, removing continence from Katz ADL resulted in a uni-dimensional scale. Females were more dependent than males in all tasks except household tasks of IADL.ConclusionsKatz ADL and Lawton IADL did not capture the actual dependency level among older Egyptians. The household tasks in Lawton IADL and continence in Katz ADL mislabeled dependency in the studied sample.
  • Utilization of drugs for the management of cardiovascular diseases at
           intermediate care facilities for older adults in Japan
    • Abstract: Publication date: Available online 25 January 2020Source: Archives of Gerontology and GeriatricsAuthor(s): Shota Hamada, Taro Kojima, Hiroshi Maruoka, Shinya Ishii, Yukari Hattori, Jiro Okochi, Masahiro AkishitaAbstractObjectivesNo established approaches exist for the pharmacological management of cardiovascular diseases (CVDs) in residents of long-term care facilities (LTCFs). This study aimed to evaluate the use of drugs for CVD prevention and treatment (CVD-related drugs) in a major type of LTCF in Japan.MethodsThis study included 1,318 randomly selected residents at 349 intermediate care facilities for older adults (called Roken). Prescriptions were investigated at admission and two months after admission according to therapeutic categories. Logistic regression was used to identify residents’ characteristics that were associated with prescriptions of CVD-related drugs.ResultsPrescriptions of all types of drugs and CVD-related drugs decreased in 36% and 16% of residents, respectively. Half of the residents received antihypertensives, a quarter received antiplatelets and diuretics, whereas one-tenth received antidiabetics, oral anticoagulants, and lipid-modifying drugs. The prevalence of most of individual drug categories were similar among residents with different physical or cognitive function, except for fewer antihypertensive and lipid-modifying drugs in those with severe cognitive disability. Adjusted analyses for prescriptions at two months after admission revealed that bedridden residents were more likely to be prescribed diuretics but less likely to be prescribed antihypertensives, antiplatelets, or lipid-modifying drugs. Residents with severe cognitive disability were less likely to be prescribed antihypertensives or lipid-modifying drugs. A known history of cardiovascular events was associated with greater use of CVD-related drugs.ConclusionCVD-related drugs were commonly prescribed for Roken residents, including those with low physical and cognitive functions. Deprescribing may contribute to the optimization of pharmacotherapy in LTCF residents.
  • Age differences in meaning in life: Exploring the mediating role of social
    • Abstract: Publication date: Available online 22 January 2020Source: Archives of Gerontology and GeriatricsAuthor(s): Neal Krause, Gerard RainvilleAbstractObjectivesThree sets of analyses are performed in our study. First, following Erikson (1959), we hypothesized that the relationship between age and meaning becomes progressively stronger at successively older ages (i.e., the relationship is nonlinear). Second, following Carstensen (1992), we predicted that the relationship between age and social support (received support and satisfaction with support) becomes progressively stronger at successively older ages (i.e., these relationships are nonlinear, as well). Third, we proposed that the nonlinear relationship between age and meaning is mediated by the nonlinear social support constructs (i.e., received support and satisfaction with support).MethodsOur data were obtained from online interviews with a nationwide sample of adults of all ages (N = 2, 245).ResultsOur findings suggest there is a nonlinear relationship between age and meaning in life as well as a nonlinear relationship between age and each social support measure. Our data also indicate that the nonlinear effects of the social support measures mediate the nonlinear relationship between age and meaning in life.DiscussionFinding a sense of meaning may be facilitated by the supportive social networks that older people maintain.
  • Cognitive and Metabolic Outcomes of Vildagliptin Addition to the Therapy
           in Patients with Type 2 Diabetes Mellitus: 26 Week Follow-up Study
    • Abstract: Publication date: Available online 20 January 2020Source: Archives of Gerontology and GeriatricsAuthor(s): Esra Ates Bulut, Zehra Yagmur Sahin Alak, Ozge Dokuzlar, Suleyman Emre Kocyigit, Pinar Soysal, Lee Smith, Ahmet Turan IsikAbstractAimsType 2 Diabetes Mellitus(DM) is a well-known risk factor for cognitive impairment. Recent evidences suggest that Dipeptidyl peptidase-4(DPP-4) inhibitors might have neuroprotective effects. Therefore, this study aimed to investigate vildagliptin, a DPP-4 inhibitor, effects on cognitive function in older patients with DM.Materials and MethodsA retrospective longitudinal clinical trial was carried out on total 130 subjects with type 2 DM. Patients underwent comprehensive geriatric assessment twice within six months interval. The patients were divided into three groups according to antidiabetic treatment: untreated control group (patients achieve individual goal HbA1c without antidiabetic medication), vildagliptin(+) group(patients using vildagliptin alone or combination) and the vildagliptin(–) group.ResultsThe mean age was 75.72 ± 7.46 years. The control group was older, of a lighter weight and also had a higher female gender ratio(p ≤ 0.01). When sex, age, educational level and metabolic profile were adjusted, there was only change in copying subdomain of Mini Mental State Examination between vildagliptin(+) and other groups at the end of 6 months. Vildagliptin also resulted in reduction of HbA1c and weight(p 
  • Home-based Evaluation of Executive Function (Home-MET) for Older Adults
           with Mild Cognitive Impairment
    • Abstract: Publication date: Available online 16 January 2020Source: Archives of Gerontology and GeriatricsAuthor(s): Frank Ho-yin Lai, Elaine Wai-hung Yan, Kathy Ka-ying YuAbstractIntroductionExecutive function helps older adults maintain their activities of daily living by making plans, setting goals, and carrying them out successfully. It is important for their independence in community living.MethodsWith a carefully match-group of 80 mild cognitive impaired with 80 health control subjects. The home-based evaluation of executive function (Home-MET) was validated in subjects’ own living environment.ResultsThis Home-MET showed significant correlation in the assessment of attention control that was assessing by Test of Everyday Attention (TEA) (r = .86, p 
  • Impact of Tai Chi Yuttari-exercise on arteriosclerosis and physical
           function in older people
    • Abstract: Publication date: Available online 10 January 2020Source: Archives of Gerontology and GeriatricsAuthor(s): Kohei Mori, Takuo Nomura, Yoshiteru Akezaki, Ryohei Yamamoto, Hirokazu IwakuraABSTRACTObjectivesThis non-randomized controlled study investigated the impact of practicing Tai Chi Yuttari-exercise for 1 year on arteriosclerosis status and physical functioning of community-dwelling older people.MethodsVascular and physical function were compared between 45 and 44 individuals who had and had not participated in Tai Chi Yuttari classes for 1 year, respectively. Participants deemed unsuitable for exercise by a physician, unable to walk unaided, with severely limited activities of daily living, with serious circulatory or respiratory disease, undergoing treatment for an acute or chronic motor organ disease, with seriously impaired motor function of the upper or lower limbs, with a history of myocardial infarction or cerebral stroke within the previous 6 months, and with previous serious infection were excluded.ResultsThe mean cardio-ankle vascular index improved significantly from 8.44 at baseline to 8.20 after 6 months in the intervention group; however, no significant difference was observed at 1 year. Conversely, compared with baseline, the functional reach, gait speed, and timed up-and-go test results improved significantly after 6 months in this group; these improvements were maintained after 1 year. No significant changes in arteriosclerosis or physical function were observed in the control group.ConclusionsThe practice of Tai Chi Yuttari-exercise is effective in maintaining and improving arteriosclerosis status and physical function in older people. However, it may be performed at least thrice a week for maintaining or improving arteriosclerosis status.Graphical abstractGraphical abstract for this article
  • Cumulative effects of cognitive impairment and frailty on functional
           decline, falls and hospitalization: A four-year follow-up study with older
    • Abstract: Publication date: March–April 2020Source: Archives of Gerontology and Geriatrics, Volume 87Author(s): Allan Gustavo Brigola, Ana Carolina Ottaviani, Tiago da Silva Alexandre, Bruna Moretti Luchesi, Sofia Cristina Iost PavariniAbstractObjectiveEvaluate the cumulative effects of cognitive impairment and frailty on functional decline, falls and hospitalization in older adults over a four-year period.MethodFour hundred five older adults (60–95 years; mean age: 70.62 ± 7.12 years), 57 % female. The frailty evaluation was performed using the clinical criteria of the Cardiovascular Health Study (CHS): weight loss, fatigue, weakness, slowness and low physical activity. Cognitive impairment was defined by cutoff scores of the Mini Mental State Examination (MMSE) based on schooling. Follow-up – functional decline was assessed using the Lawton&Brody scale of instrumental activities of daily living (IADL). An investigation was also performed of the occurrence of falls and admissions to the hospital in the previous twelve months.ResultsCognitive impairment was associated with admissions to the hospital and declines in the IADL category of using a telephone. Frailty was associated with admissions to hospital. Cumulative effects were observed for hospitalization and the decline in using the telephone and shopping. Frailty and cognitive impairment increased the risk of being admitted to hospital by 557 % and increased the risk of a decline in using the phone by 262% and shopping by 208%. No conditions were associated with the risk of falls.ConclusionThe combination of the MMSE and the CHS criteria was adequate for measuring the cumulative effects of cognitive impairment and frailty. Shared physiological mechanisms may explain the relation between cognitive impairment and frailty, but further investigations are needed in Brazil and other low/middle-income countries.
  • Determination of the costs of falls in the older people according to the
           decision tree model
    • Abstract: Publication date: March–April 2020Source: Archives of Gerontology and Geriatrics, Volume 87Author(s): Gamze Ağartioğlu Kundakçi, Medine Yılmaz, Melih Kaan SözmenAbstractPurpose of the researchThe primary aim of this study is to hypothetically examine the costs of falls experienced by the older people living in the community and fall prevention interventions implemented by nurses using the decision tree model. The secondary purpose of the study is to determine the factors affecting the cost of falls.The materials and methodsThis study was planned as a costing and cost-effectiveness study. Two thousand seventy-five patient files were examined by following the research criteria. In the present study, a hypothetical analytical decision tree model was used. Three different scenarios were set up in the study, and the decision tree analyses were performed according to these scenarios. Falls will decrease by 12 % in the pessimistic scenario, by 27 % in the optimal scenario, and by 39 % in the optimistic scenario. The SPSS 22.0 (2014) and TreeAge Pro Suit (2009) programs were used for data analysis.The principal resultsThe average cost for a person admitted to a hospital due to falls was $396.51 ± $1429.35.It was determined that costs varied according to the type of the injury.The results of this present study demonstrated that the three scenarios tested were costly but also more effective. Hence, the applicability of these interventions should be considered by policy makers taking both the costs and effectiveness into account.Major conclusionsMultidisciplinary research should be carried out in order to increase the effectiveness of the fall prevention programs to be implemented in the future, and multifaceted fall prevention programs should be developed.
  • Allostatic load and stress biomarkers in a sample of community-dwelling
           older adults
    • Abstract: Publication date: March–April 2020Source: Archives of Gerontology and Geriatrics, Volume 87Author(s): Aline do Nascimento Falcão Freire, Juliana Fernandes de Souza Barbosa, Daniele Sirineu Pereira, Cristiano dos Santos Gomes, Ricardo Oliveira GuerraAbstractBackgroundThe idea that cumulative levels of stress can have deleterious effects on health and longevity has led investigators to discuss individual differences in the accumulation of Allostatic Load (AL) during life. Our aim was to evaluate the AL indices and stress biomarkers between genders and to determine which factors were more associated with AL indices.MethodsWe evaluated 256 subjects, including 88 men and 168 women, aged 65 years or more. AL was measured by 10 biomarkers, including systolic and diastolic blood pressure, waist-hip ratio, glycosylated hemoglobin, salivary cortisol, salivary dehydroepiandrosterone sulphate, urinary epinephrine and norepinephrine, total cholesterol and total cholesterol/HDL. Sociodemographic and clinical characteristics, cognitive function and physical functional variables were additionally analyzed.ResultsThe mean age of the participants was 74.1 ± 6.7 years. The AL index was 2.30 ± 1.68, without a significant difference between gender. The final linear regression model controlling for gender, age, years of study and living arrangement showed that AL was associated to a number of chronic conditions (β = 0.24; 95 % CI: 0.08–0.40), mobility disability (β = 0.58; 95 % CI: 0.06–1.14), and handgrip strength (β = 0.06; 95 % CI: 0.06–1.14).ConclusionAs a result of this investigation, Allostatic load was shown to be associated with poor health or physical function for community-dwelling older adults.
  • Mid-arm muscle circumference as an indicator of osteoporosis in
           community-dwelling older men
    • Abstract: Publication date: March–April 2020Source: Archives of Gerontology and Geriatrics, Volume 87Author(s): Yuan-Ping Chao, Tung-Wei Kao, Wei-Liang Chen, Tao-Chun Peng, Li-Wei WuAbstractBackgroundOsteoporosis is an underdiagnosed disease and is lack of convenient and cost-efficient screening tool. We undertook a study to determine whether mid-arm muscle circumference (MAMC) was associated with osteoporosis.DesignData were retrieved from the National Health and Nutrition Examination Survey (NHANES) III participants (aged 40–90 years). We divided the MAMC into tertile groups (T1, T2, and T3). Femoral neck bone density was analyzed because it was the reference skeletal site for defining osteoporosis in epidemiological studies. Participants with T- scores ≤ –2.5 were categorized as having osteoporosis. Multivariate logistic regression models were used to evaluate the associations between the MAMC tertiles and osteoporosis.ResultsAfter adjustment for multiple covariates, osteoporosis was significantly inversely associated with the MAMC tertiles in the male group (T2/T1: OR 0.47, 95 % CI 0.30–0.75 and T3/T1: OR 0.34, 95 % CI 0.18–0.64), whereas nonsignificant association was found in the female group (T2/T1: OR 0.92, 95 % CI 0.70–1.20 and T3/T1: OR 0.84, 95 % CI 0.47–1.53). Subgroup analyses (40–64 and ≥65 years old; BMI
  • Visual dependence affects the motor behavior of older adults during the
           Timed Up and Go (TUG) test
    • Abstract: Publication date: March–April 2020Source: Archives of Gerontology and Geriatrics, Volume 87Author(s): Rania Almajid, Carole Tucker, William Geoffrey Wright, Erin Vasudevan, Emily KeshnerAbstractBackgroundOlder adults show greater postural instabilities under misleading visual cues relative to younger adults. We investigated the effects of age-related visual dependence on motor performance under increased attention demands by adding a motor task and visual stimulus to the Timed Up and Go (TUG) test sub-components.MethodWe designed a cross-sectional quantitative study. Twenty-eight younger (n = 12) and older (n = 16) adults completed the TUG test while wearing a head-mounted display (HMD) that presented a visual stimulus and/or carrying a cup of water. Outcome measures were turning cadence; gait speed; pitch, yaw, and roll peak trunk velocities (PTVs); and acceleration ranges of sit-to-stand and stand-to-sit.ResultsWearing the HMD caused significant performance differences in the TUG test tasks due to age and visual dependence, although performance was lower across all groups with the HMD (p < 0.01). Older adults showed lower roll PTV in turning compared to younger adults (p = 0.03). Visually dependent older adults showed smaller mediolateral and vertical acceleration ranges (p < 0.04) in sit-to-stand compared to visually independent older adults.ConclusionThe demand for orienting posture to a vertical position during sit-to-stand may differentiate older adults who are more visually dependent—and thus at greater fall risk— from those who are more visually independent. Age-related differences in turning behavior suggest a relationship with fall risk that warrants further investigation.
  • Interaction of central obesity and sarcopenia on nutritional status in the
           community-dwelling older people
    • Abstract: Publication date: March–April 2020Source: Archives of Gerontology and Geriatrics, Volume 87Author(s): Chin -Sung Chang, Yin-Fan Chang, Ping-Yen Liu, Shin-Jiuan Wu, Ching-Ju Chiu, Chuan-Yu Chen, Chih-Hsing WuAbstractObjectivesTo investigate the interrelationships between central obesity, sarcopenia and nutritional status in the elderly.MethodsWe enrolled 501 elderly (women: 47.5 %) with complete datasets. Biochemical and anthropometric data were measured after an overnight fast. Basic characteristics, psychosocial and behavioral factors, nutritional status, and history of chronic disease came from structured questionnaires. Central obesity was defined as waist circumference ≥ 90 cm for men, ≥ 80 cm for women. Sarcopenia was defined by the Asian consensus. Nutritional status was assessed using Mini Nutritional Assessment scores: abnormal nutritional status ≤ 23.5. Multiple logistic regression analysis was done to determine the independent factors of an abnormal nutritional status.ResultsNinety (18.0 %) participants had an abnormal nutritional status, 300 (59.9 %) had central obesity, 52 (10.4 %) sarcopenia and 3 (0.6 %) sarcopenic obesity. Central obesity (OR = 0.455, 95 % CI: 0.244-0.847) and total lymphocyte count (OR = 0.526, 95 % CI: 0.315-0.880) were negatively and sarcopenia (OR = 3.170, 95 % CI: 1.485–6.767), current smoking (OR = 4.071, 95 % CI: 1.357–12.211), and total number of chronic diseases (OR = 1.484, 95 % CI: 1.234–1.785) were positively associated with abnormal nutritional status. An analysis of the combine effects of central obesity and sarcopenia on nutritional status showed that significantly fewer participants with central obesity but not sarcopenia had abnormal nutrition than participants with sarcopenia with or without central obesity (12.8 % vs 38.5 or 65.4 %, p 
  • Combined effects of frailty status and cognitive impairment on
           health-related quality of life among community dwelling older adults
    • Abstract: Publication date: March–April 2020Source: Archives of Gerontology and Geriatrics, Volume 87Author(s): Chia-Lin Li, Hsing-Yi Chang, Fiona F. StanawayAbstractObjectivesThe aim of the present study was to investigate the combined association of frailty/pre-frailty and cognitive impairment with health related quality of life (HRQOL) among community dwelling older adults.MethodsData came from a cross-sectional study of community-dwelling older adults aged 65 years or older, who participated in the 2013 National Health Interview Survey in Taiwan. Frailty was determined based on the Fatigue, Resistance, Ambulation, Illness, and Loss of weight (FRAIL) scale proposed by the International Association of Nutrition and Aging. The Mini-Mental State Examination was used to assess cognitive function. HRQOL was measured using the European Quality of Life-5 Dimensions questionnaire (EQ-5D) that assesses three levels of functioning for the dimensions of mobility, self-care, usual activities, pain/discomfort, and anxiety/depression. Poisson regression models were performed to estimate prevalence ratios (PR) and 95 % Confidence Intervals (95 % CI) for health problems in all EQ-5D domains.ResultsIn this study, 11.0 % of participants aged 65 years and older had co-occurring frailty/pre-frailty and cognitive impairment. After adjustment for other factors, compared with participants who were physically robust with normal cognition, participants with co-occurring frailty/pre-frailty and cognitive impairment had PRs of 10.38 (95 % CI 7.56–14.26), 9.66 (95 % CI 6.03–15.48), 9.37 (95 % CI 6.92–12.68), 3.04 (95 % CI 2.53–3.64), and 5.63 (95 % CI 3.83–8.28) for reporting problems with mobility, self-care, usual activities, pain/discomfort, and anxiety/depression, respectively.ConclusionsThere is a high prevalence of co-occurrence of frailty/pre-frailty and cognitive impairment in older adults, and this co-occurrence was strongly associated with self-reported health problems across all EQ-5D domains.
  • Elevation of plasma soluble amyloid precursor protein beta in
           Alzheimer’s disease
    • Abstract: Publication date: March–April 2020Source: Archives of Gerontology and Geriatrics, Volume 87Author(s): Sang-Moon Yun, Sun-Jung Cho, Chulman Jo, Moon Ho Park, Changsu Han, Young Ho KohAbstractIntroductionBeta-amyloid is considered to be a pathophysiological marker in Alzheimer's disease (AD). Soluble amyloid precursor proteins (sAPPs) –α (sAPPα) and –β (sAPPβ), which are the byproducts of non-amyloidogenic and amyloidogenic process of APP, respectively, have been repeatedly observed in the cerebrospinal fluids (CSF) of AD patients. The present study focused on the determination of sAPP levels in peripheral blood.MethodsThe plasma protein levels of sAPPα and sAPPβ were measured with ELISA. Plasma from 52 AD patients, 98 amnestic mild cognitive impairment (MCI) patients, and 114 cognitively normal controls were compared.ResultsThe plasma level of sAPPβ was significantly increased in AD patients than in cognitively healthy controls. However, no significant change in plasma sAPPα was observed among the three groups. Furthermore, the plasma sAPPβ levels significantly correlated with cognitive assessment scales, such as clinical dementia rating (CDR), and mini-mental status examination (MMSE). Interestingly, sAPPα and sAPPβ had a positive correlation with each other in blood plasma, similar to previous studies on CSF sAPP. This correlation was stronger in the MCI and AD groups than in the cognitively healthy controls.ConclusionsThese results suggest that individuals with elevated plasma sAPPβ levels are at an increased risk of AD; elevation in these levels may reflect the progression of disease.
  • Improving gesture-based interaction between an assistive bathing robot and
           older adults via user training on the gestural commands
    • Abstract: Publication date: March–April 2020Source: Archives of Gerontology and Geriatrics, Volume 87Author(s): Christian Werner, Nikos Kardaris, Petros Koutras, Athanasia Zlatintsi, Petros Maragos, Jürgen M. Bauer, Klaus HauerAbstractBackgroundGesture-based human-robot interaction (HRI) depends on the technical performance of the robot-integrated gesture recognition system (GRS) and on the gestural performance of the robot user, which has been shown to be rather low in older adults. Training of gestural commands (GCs) might improve the quality of older users’ input for gesture-based HRI, which in turn may lead to an overall improved HRI.ObjectiveTo evaluate the effects of a user training on gesture-based HRI between an assistive bathing robot and potential elderly robot users.MethodsTwenty-five older adults with bathing disability participated in this quasi-experimental, single-group, pre-/post-test study and underwent a specific user training (10−15 min) on GCs for HRI with the assistive bathing robot. Outcomes measured before and after training included participants’ gestural performance assessed by a scoring method of an established test of gesture production (TULIA) and sensor-based gestural performance (SGP) scores derived from the GRS-recorded data, and robot’s command recognition rate (CRR).ResultsGestural performance (TULIA = +57.1 ± 56.2 %, SGP scores = +41.1 ± 74.4 %) and CRR (+31.9 ± 51.2 %) significantly improved over training (p 
  • The relationship between gender roles and self-rated health: A perspective
           from an international study
    • Abstract: Publication date: March–April 2020Source: Archives of Gerontology and Geriatrics, Volume 87Author(s): Megan Willerth, Tamer Ahmed, Susan P. Phillips, Mario Ulises Pérez-Zepeda, Maria Victoria Zunzunegui, Mohammad AuaisAbstractObjectivesTo examine the relationship between gender roles and self-rated health in older men and women from different contexts.Methods2002 community-dwelling older adults from the International Mobility in Aging Study were recruited from 5 research sites. Gender role was measured with the 12-item Bem Sex Role Inventory, which categorized study participants into four gender roles: Masculine, Feminine, Androgynous, and Undifferentiated. Self-rated health was collapsed into a dichotomous variable (Very Good/Good and Fair/Poor/Very Poor). Prevalence risk ratios (PRR) of self-rated health relative to gender roles were estimated with Poisson regression models adjusted for all relevant confounders.ResultsAfter complete adjustment, feminine (PRR 1.22 (95 % CI 1.01–1.49)) and undifferentiated (PRR 1.25 (95 % CI 1.05–1.50)) gender roles were associated with poorer relative self-rated health.DiscussionGender roles confer independent risks and benefits for self-rated health in older adults.
  • Pain as a risk factor for suicidal behavior in older adults: A systematic
    • Abstract: Publication date: March–April 2020Source: Archives of Gerontology and Geriatrics, Volume 87Author(s): Joaquim Santos, Sónia Martins, Luís F. Azevedo, Lia FernandesObjectiveThe objective of this systematic review was to examine whether pain is a risk factor for suicidal behavior (suicide ideation, suicide attempts or suicide) in older adults.Material and methodsAn extensive search was conducted on the following databases: MEDLINE, ISI Web of Knowledge, Scopus and PsycARTICLES. Search terms used were “pain”, “suicid*” and “elderly”. Studies that assessed the relation between pain and suicidal behavior among people aged ≥60 years were included. Two reviewers independently screened the abstracts and applied selection criteria in the full-text of all included articles.ResultsResults from 38 original research articles were included and reviewed. Moderate/severe pain increased the risk of suicide ideation from OR = 1.13 (95 %CI = 1.02–1.25) to OR = 2.7 (95 %CI = 1.1–7.0). The influence in suicide attempts ranged between OR = 1.92 (95 %CI 1.17–3.15) and 3.63-fold for extreme pain; and one article reported that the risk of a successful suicide was 4.07-fold higher in pain suffering patients. In most studies, this relation was maintained, even after controlling for other risk factors. Arthritis, back/neck problems and headaches were associated with higher risks of suicidal behavior. Pain was also a stronger predictor for suicide in men (OR = 9.9; 95 %CI = 6.0–16.4) than in women (OR = 3.3; 95 %CI = 1.4–7.7).ConclusionOur results suggest the existence of a relationship between pain and suicidal behavior in older adults. This information may be extremely relevant to inform suicide prevention strategies.
  • Diagnostic accuracy of various forms of geriatric depression scale for
           screening of depression among older adults: Systematic review and
    • Abstract: Publication date: March–April 2020Source: Archives of Gerontology and Geriatrics, Volume 87Author(s): Yuvaraj Krishnamoorthy, Sathish Rajaa, Tanveer RehmanAbstractObjectivesDepression is under-reported and under-identified by the healthcare professionals. Geriatric depression scale (GDS) is one of the most commonly used instruments for screening the older adults for depression. The current review was done to determine the diagnostic accuracy of various forms of GDS for screening of depression among older adults.MethodsWe conducted systematic search in various databases like Medline, Cochrane library, Sciencedirect and Google Scholar from inception till May 2019. Quality of trials was assessed by Quality Assessment of Diagnostic Accuracy Studies-2 tool. We performed bivariate meta-analysis to obtain the pooled sensitivity, specificity, positive, negative likelihood ratio and diagnostic odds ratio for each of the GDS forms.ResultsTotally 53 studies with 17,018 participants were included in the review. We found the pooled sensitivity and specificity of GDS 30 to be 82 % and 76 % with near higher diagnostic accuracy (AUC = 0.85). GDS 15 had pooled sensitivity and specificity of 86 % and 79 % with higher diagnostic accuracy (AUC = 0.90). GDS 10 had pooled sensitivity and specificity of 87 % and 75 % with AUC = 0.83. Our study found GDS 4 to have sensitivity of 74 % with specificity of 71 %. All the four forms of GDS belonged to right lower quadrant of LR scatter-gram indicating neither confirmation nor exclusion.ConclusionCurrent study found that all the forms of GDS are highly useful for detecting depression among elderly with higher sensitivity and specificity. The diagnostic performance was much better for shorter forms of GDS such as GDS 15 and GDS 10 when compared to GDS 30.
  • Cognitive frailty as a predictor of dementia among older adults: A
           systematic review and meta-analysis
    • Abstract: Publication date: March–April 2020Source: Archives of Gerontology and Geriatrics, Volume 87Author(s): Lufang Zheng, Guichen Li, Dawei Gao, Shuo Wang, Xiangfei Meng, Cong Wang, Haibo Yuan, Li ChenAbstractObjectiveThe aim of this systematic review and meta-analysis was to synthesize the pooled risk effect and to determine whether cognitive frailty is a predictor of dementia among older adults.DesignSystematic review and meta-analysis.Setting and participantsPubMed, EMBASE, Web of Science, and the Cochrane Library were systematically searched until June 5, 2019. Only cohort studies and population-based longitudinal studies published in English were eligible. Study selection, data extraction and quality assessment of including studies were independently completed by two researchers. A fixed-effects model was used to synthesize the risk of baseline cognitive frailty on dementia in the older adults compared with older adults without cognitive frailty.MeasurementsThe risk of cognitive frailty on incident dementia.ResultsOf the 1566 identified records, 7 studies met the inclusion criteria and were included in the review. And 4 studies reporting hazard ratio (HR) of incident dementia for cognitive frailty were included in the meta-analysis. Synthesized results showed that baseline cognitive frailty in the elderly was significantly associated with an increased risk of developing dementia as compared with those without cognitive frailty (prefrailty + CI model: pooled HR = 3.99, 95 %CI = 2.94–5.43, p 
  • Clinical relevance of different handgrip strength indexes and metabolic
           syndrome in Chinese community-dwelling elderly individuals
    • Abstract: Publication date: Available online 3 January 2020Source: Archives of Gerontology and GeriatricsAuthor(s): Peiyu Song, Yuanyuan Zhang, Yue Wang, Peipei Han, Liyuan Fu, Xiaoyu Chen, Hairui Yu, Lin Hou, Xing Yu, Lu Wang, Fengying Yang, Qi GuoAbstractPurposeCurrently there is no consensus on the correlation between metabolic syndrome (MetS) and muscle strength. The objective of this study was to examine the associations between MetS and its components and different handgrip strength (HS) indexes among Chinese community-dwelling elderly individuals. In addition, we hoped to find an optimal cutoff point for the index most relevant to MetS.MethodsData were obtained from 909 participants aged ≥ 60 years (385 men, average age, 68.0 ± 5.9 y). We used the International Diabetes Federation metabolic syndrome guidelines to define MetS. General data of all participants were collected through questionnaires and anthropometric data were measured. At the same time, blood samples were collected.ResultsThe prevalence of MetS was 26.8% in men and 46.9% in women. In all HS indexes, HS/body fat mass was most strongly correlated with MetS, and the areas under the receiver-operating characteristic curve were 0.723 (95% confidence interval [CI] = 0.669-0.776) in men and 0.619 (95% CI = 0.571-0.667) in women, and the optimal cutoffs were 1.92 in men and 1.25 in women. The adjusted odds ratios (ORs) of MetS for low HS/body fat mass were 5.38 (95% CI = 3.03-9.56, p 
  • The Effect of Severity of White Matter Hyperintensities on Loss of
           Functional Independency in Patients with Mild Cognitive Impairment: a
           CREDOS-LTCI (Clinical Research Center for Dementia of South Korea-Long
           Term Card Insurance) Study
    • Abstract: Publication date: Available online 3 December 2019Source: Archives of Gerontology and GeriatricsAuthor(s): Han Eol Cho, Seong Hye Choi, Hyun Sun Lim, Jong Hun Kim, Hyoung Seop KimAbstractObjectiveBy combining data from the Clinical Research Center for Dementia of South Korea(CREDOS) study and long-term care insurance(LTCI), we aimed to assess whether the severity of white matter hyperintensity(WMH) predicted functional decline in cases of amnestic mild cognitive impairment(MCI).MethodsWMH was evaluated in 3,569 patients with amnestic MCI using the visual rating scale developed for the CREDOS study. The participants were classified as having amnestic MCI with minimal WMH change(aMCI), with moderate WMH change(maMCI) and with severe WMH change(saMCI) according to the severity of the WMH measurements. A Kaplan–Meier survival probability estimate was used to compute median time from the diagnosis of MCI to LTCI enrollment for the three MCI groups. The effect of various risk factors of LTCI enrollment was evaluated using Cox’s proportional hazards model, adjusted for covariates.ResultsAs compared with aMCI cases, maMCI and saMCI patients required help with daily activities of living at a younger age. The saMCI and maMCI patients had higher risk of LTCI enrollment as compared with that of the aMCI patients. Younger patients(≤ 65y) with MCI had a 3.201 times higher risk of early LTCI enrollment than older patients(> 65y) did. High clinical dementia rating score and female sex were also risk factors of early LTCI enrollment.ConclusionsWMH predicted the rate of global functional decline and loss of independence in patients with MCI. The findings support the use of neuroimaging of WMH, in conjunction with biomarkers, as a tool in predicting functional decline in patients with MCI.
  • Investigating Associations Between Personality and the Efficacy of
           Interventions for Cognitive Ageing: A Systematic Review
    • Abstract: Publication date: Available online 2 December 2019Source: Archives of Gerontology and GeriatricsAuthor(s): Calum Marr, Eleftheria Vaportzis, Michaela Dewar, Alan J. GowAbstractThe personal and societal impact of age-related cognitive decline supports the development of effective interventions. While some strategies, such as cognitive training, exercise or socio-intellectual engagement appear beneficial, few studies have examined the association between personality and intervention efficacy. A systematic review was therefore conducted to summarise and synthesise the literature regarding the influence of personality traits on the effectiveness of non-pharmacological interventions for cognitive ageing. A systematic search of PubMed, PsycINFO and Web of Science was carried out. Of the 2100 papers identified by the search strategy, 10 studies were retained that met the relevant criteria (e.g., intervention studies with one or more cognitive outcomes and a measure of personality). Of these, two studies reported that higher levels of Openness to Experience were associated with greater improvement in memory performance after cognitive training interventions. Another found a positive association between Openness and improvement in divergent thinking following a novel group-based problem solving programme. One social intervention study reported positive moderating effects of Conscientiousness and Agreeableness, and mixed effects of Extraversion. Mixed evidence was also found regarding Need for Cognition, with one study reporting a positive association with memory improvement and another reporting less improvement in divergent thinking. Others found no evidence of personality influencing intervention outcomes. Due to the relatively small and heterogeneous sample of studies identified, any conclusions should currently be considered preliminary. These findings highlight the need for further research exploring the role of personality in intervention efficacy, so that interventions might be better tailored to individuals.
  • The association between pain and prevalent and incident Motoric Cognitive
           Risk syndrome in older adults
    • Abstract: Publication date: Available online 30 November 2019Source: Archives of Gerontology and GeriatricsAuthor(s): Guusje van der Leeuw, Emmeline Ayers, Annette H. Blankenstein, Henriëtte E. van der Horst, Joe VergheseAbstractBackgroundThe Motoric Cognitive Risk Syndrome (MCR) is a pre-dementia syndrome characterized by subjective cognitive complaints and slow gait in the absence of dementia and mobility disability. Worse cognitive and motoric function is associated with chronic pain in older adults. Our aim was to study the association between pain and prevalent and incident MCR in adults aged 65 years and older.MethodsWe analyzed the cross-sectional association between severity of pain and prevalent MCR in 3,244 older adults participating in the Health and Retirement Study (2008 wave) using logistic regression analysis adjusting for demographic, peripheral, central or biological risk factors. Additionally, we analyzed the longitudinal association between severity of pain and incident MCR in 362 participants in the Central Control of Mobility in Aging Study, using Cox regression analysis.ResultsThe 155 Health and Retirement Study participants with severe pain had an increased risk of prevalent MCR (n = 249), compared to 2245 individuals without pain (adjusted for demographics OR: 2.78, 95% CI:1.74-4.45).Over a mean follow-up of 3.01 years (SD 1.38), 29 individuals in the Central Control of Mobility in Aging Study developed incident MCR. Older adults with severe pain had over a five times increased risk of developing incident MCR, compared to those without pain even after adjusting for demographic variables (HR: 5.44, 95% CI: 1.81-16.40).ConclusionOlder adults with severe pain have a higher prevalence and incidence of MCR. These findings should be further explored to establish if pain is a potentially modifiable risk factor to prevent cognitive decline.
  • Relationship of low muscle mass and obesity with physical function in
           community dwelling older adults: Results from the Nagahama study
    • Abstract: Publication date: Available online 26 November 2019Source: Archives of Gerontology and GeriatricsAuthor(s): Masayo Tanaka, Tome Ikezoe, Noriaki Ichihashi, Yasuharu Tabara, Takeo Nakayama, Yoshimitsu Takahashi, Fumihiko Matsuda, Tadao Tsuboyama, on behalf of the Nagahama Study groupAbstractAimRelationships of low muscle mass and obesity with physical function were investigated in older adults.MethodsThe participants were 1,922 community dwelling persons aged 60 years or older (67.7 ± 5.2 years old, 643 men and 1,279 women). One-leg standing time, knee extensor muscle strength, and maximum walking speed were assessed. Muscle mass was evaluated using the bioelectrical impedance analysis (BIA) method, and skeletal mass index (SMI) was determined. For the obesity index, waist circumference with a stronger association with visceral fat was used. Participants were classified into the following four groups based on standard values of waist circumference and SMI: non-obese low-SMI, obese low-SMI, non-obese normal-SMI, and obese normal-SMI.ResultsBy two-way analysis of variance (obesity × SMI), the main effects of waist circumference and muscle mass were noted in the one-leg standing time. The maximum walking speed was higher in the non-obese than the obese group, and in the normal than the low SMI group. In the muscle strength, a main effect was noted only in the muscle mass of women. An interaction was noted in men and significant differences were detected between all combinations except between the non-obese low SMI and obese low SMI groups.ConclusionLow muscle mass and obesity negatively influence balance and walking abilities. However, the influence of low muscle mass and obesity on muscle strength were different between the sexes. In men, the relationship between obesity and muscle strength would be different depending on whether muscle mass is retained.
  • Motoric cognitive risk syndrome is associated with processing speed and
           executive function, but not delayed free recall memory: The Korean Frailty
           and Aging Cohort Study (KFACS)
    • Abstract: Publication date: Available online 19 November 2019Source: Archives of Gerontology and GeriatricsAuthor(s): Hayoung Shim, Miji Kim, Chang Won WonAbstractBackgroundThe motoric cognitive risk (MCR) syndrome, characterized by slow gait and cognitive complaints, is a high risk for transitioning to dementia. However, little is known regarding the cognitive profile among individuals with MCR. This study was performed to examine the association of MCR with cognitive functional domains.MethodsWe analyzed 2,881 community-dwelling older adults aged 70-84 years (52% women, mean age: 75.9 years) from the nationwide Korean Frailty and Aging Cohort Study. MCR was defined as the presence of subjective cognitive complaints and slow gait ≥1.0 standard deviations below age- and sex-specific means. Cognitive function was assessed using the Korean version of the Consortium to Establish a Registry for Alzheimer’s Disease Assessment Packet and the Frontal Assessment Battery.ResultsA total of 231 participants met MCR criteria (prevalence = 8.02%; 95% confidence interval [CI]: 7.07–9.08%). The prevalence of MCR did not increase with advancing age: 70–74 years, 8.90%; 75–79 years, 7.06%; and 80–84 years, 8.04%; moreover, there were no sex-related differences. After adjusting for various confounders, MCR was associated with decline in global cognitive function, attention, processing speed and executive function (all P < 0.05). In particular, MCR was significantly associated with impairments in processing speed (odds ratio [OR]: 1.89, 95% CI: 1.16–3.07) and executive function (OR: 1.94, 95% CI: 1.28-2.93) (P >  0.05).ConclusionsMCR was associated with deficits in global cognition, processing speed, and executive function, but not delayed free recall memory. Individuals with MCR had an increased risk of poor cognitive profile related to brain frontal to prefrontal function.
           IN VIETNAM
    • Abstract: Publication date: Available online 19 November 2019Source: Archives of Gerontology and GeriatricsAuthor(s): Dung Duc Le, Roberto Leon Gonzalez, Long Thanh GiangAbstractObjectivesThis study compared functional disability in older men and women, and examined the extent to which social determinants contribute to the difference in functional disability between Vietnamese older men and women.MethodsA nationally representative sample of persons aged 60 and older in Vietnam, taken from the 2011 Vietnam Aging Survey, was analyzed (N = 2,693, consisting of 1,622 women and 1,071 men). Ordinary least squares regression (OLS) was used to identify factors associated with functional disability in men and women, while Oaxaca-Blinder decomposition for linear models was applied to examine how much of gender inequality in functional disability was attributed by the distribution of the social determinants.ResultsThe OLS results showed that functional disability score for women was significantly higher than that for men, and that men and women shared similarity in factors associated with functional disability (e.g., age, educational level, employment status, and perceived sufficiency of income). The decomposition results showed that the distribution of the social determinants explained about 54 per cent of gender inequality in functional disability; among the determinants, age, employment status, and educational level were the major drivers. Approximately 46 per cent of the inequality was explained by unobserved factors.ConclusionThe findings of this study highlight the need for policy to mitigate the social determinants (e.g., education and employment) that contribute to gender inequality in functional disability.
  • Epidemiology of Frailty and Associated Factors among Older Adults Living
           in Rural Communities in Taiwan
    • Abstract: Publication date: Available online 18 November 2019Source: Archives of Gerontology and GeriatricsAuthor(s): Chung-Yu Huang, Wei-Ju Lee, Hui-Ping Lin, Ren-Chou Chen, Chi-Hung Lin, Li-Ning Peng, Liang-Kung ChenAbstractFrailty is a well-known geriatric syndrome with strong adverse health impact to older people. The socio-economic status and the accessibility of health services in rural communities may increase the risk of frailty. We conducted a cross-sectional study in rural districts of New Taipei City, Taiwan, to explore the epidemiology and associated factors of frailty. Data of 1,014 participants (mean age: 78.7 ± 8.0 years, 66.3% females) were obtained with the prevalence of frailty and pre-frailty 17.6% and 23.1%, respectively. The mean Barthel Index was 98.5 ± 5.8, and their mean Instrumental Activities of Daily Living (IADL) were 7.2 ± 1.5. Frail older people tended perform worse in timed up-and-go tests (24.7% in frailty and 0.4% in robust). The mean mini-mental state examination (MMSE) score for all participants was 23.3 ± 5.1, but was lower in frail older for around 5 points. Depressive symptoms were more common in frail older persons than robust ones (31.5% vs 14.3%), which was similar in the nutritional status. Results of the logistic regression showed that better education, IADL and MMSE scores were protective factors against frailty. The presence of depressive symptoms, urinary incontinence, abnormal performance of TUG, and the presence of the risk for malnutrition were all independent assciated factors for frailty. In conclusion, the prevalence of frailty was higher among older adults living in rural communities that deserves specific public health attentions. Further intervention study covering special needs in rural communities is needed to promote health of older people.
  • Perceived risk of institutionalization, hospitalization, and death in
           oldest old primary care patients
    • Abstract: Publication date: Available online 18 November 2019Source: Archives of Gerontology and GeriatricsAuthor(s): Daniela Brandão, Oscar Ribeiro, Laetitia Teixeira, Constança PaúlAbstractObjectivesThis study aims to analyze the accuracy and predictive ability of the Risk Instrument for Screening in the Community (RISC) scored by general practitioners (GPs) in a sample of primary care patients aged 80+ with perceived mental health concerns.MethodGPs ranked the perceived risk of the three adverse outcomes (hospitalization, institutionalization and death) at 1 year in a five Likert scale (RISC score), where 1 is the lowest risk and 5 is the highest. Follow up contacts were conducted after 1 year of assessment in order to collect data on the three outcomes.ResultsThe 1-year proportion of institutionalization, hospitalization and death were 12.1%, 25.2% and 19.0% respectively. Based upon the sensitivity and specificity from the Receiver Operating Characteristic (ROC) curves, we found an optimal cut-off point of ≥4 for the RISC. The RISC had fair accuracy for 1-year risk of institutionalization (Area Under the ROC curve (AUC) = 0.75, 95% CI 0.43-0.68) and hospitalization (AUC = 0.65, 95% CI 0.52-0.78), but not for death (AUC = 0.55, 95% CI 0.43-0.68).ConclusionsThe RISC as a short global subjective assessment is to be considered a reliable tool for use by GPs. Our results showed that RISC seems to be a good instrument to triage very old people at risk for institutionalization but with poor accuracy at predicting hospitalization and limited predictive ability for death, suggesting further research and caution on this instrument’s use.
  • Age and sex differences in frontal lobe cerebral oxygenation in older
           adults – normative values using novel, scalable technology: Findings
           from the Irish Longitudinal Study on Ageing (TILDA)
    • Abstract: Publication date: Available online 18 November 2019Source: Archives of Gerontology and GeriatricsAuthor(s): Louise Newman, Hugh Nolan, Daniel Carey, Richard B. Reilly, Rose Anne KennyAbstractAimsNear-infrared spectroscopy (NIRS) is a non-invasive, easy to apply, optical technology for measuring cerebral blood oxygenation, but there is lack of comprehensive population data to aid interpretation and clinical use. Given the importance of cerebral perfusion in the context of evolving guideline recommendations for more aggressive lowering of blood pressure (BP) in hypertension, even in the oldest old, understanding of normative NIRS values is timely. We estimated normative values of cerebral oxygenation measured by NIRS in a large community-dwelling population sample of adults aged> = 50 years (n = 3,110). We hypothesized that measurements would be attenuated by cardiovascular risk factors.MethodsData from Wave 3 of The Irish Longitudinal Study on Ageing (TILDA) was utilized. Frontal lobe cerebral oxygenation was continuously measured via a Portalite, while participants rested in the supine position. Beat-to-beat BP was measured simultaneously. Normative data was modelled using generalized additive models for location, scale, and shape (GAMLSS). Multivariate linear regressions were used to examine associations with cardiovascular risk factors.ResultsAll three measures of NIRS (TSI, O2Hb and HHb) declined with increasing age. O2Hb and HHb were significantly lower in males than females. Increased smoking, excess alcohol intake, a higher waist-hip ratio, diabetes, angina, congestive heart failure, transient ischemic attack and total cardiovascular disease burden were all associated with decreased cerebral oxygenation.ConclusionWe present for the first time, normative resting-state NIRS reference data from a large population, which contributes to clinical interpretation of NIRS and advances the use of NIRS as a standard clinical tool.
  • Frailty, physical function and affective status in elderly patients on
    • Abstract: Publication date: Available online 11 November 2019Source: Archives of Gerontology and GeriatricsAuthor(s): Aurora López-Montes, María Martínez-Villaescusa, Ana Pérez-Rodríguez, Elena Andrés-Monpeán, Mercedes Martínez-Díaz, Jesús Masiá, José M Giménez-Bachs, Pedro AbizandaAbstractObjetivesTo analyze depression, cognition, and physical function change in older adults on hemodialysis at 12-month follow-up, depending on frailty status.DesignOngoing cohort study.Participants117 patients older than 69 years on hemodialysis; 75 men.MeasurementsFrailty was measured with the frailty phenotype, disability in basic and instrumental activities of daily living with the Barthel and Lawton index respectively, physical function with the Short Physical Performance Battery (SPPB), cognitive status with the Mini Cognitive Examination, and depression with the Yesavage´s Geriatric Depression Scale (GDS), at hemodialysis initiation and after 12-month follow-up. Inflammatory and nutrition profile was determined with C-reactive protein (CRP), albumin, and haemoglobin levels.ResultsThe mean age of the participants was 78.1 years; 63 (53.8%) were frail. Frail participants had a higher 12-month mortality risk compared to the non frail ones, hazard ratio 2.6 (95% CI 0.9-7.9). Frail 12-month survivors presented an improvement in median GDS scores (10 to 9; p = .009). There was no change in frail survivors from SPPB ≤ 6 to SPPB> 6 and a shift in 29.3% of non-frail survivors from SPPB> 6 to SPPB ≤ 6 (p = .007) after 12-month follow-up. Median CRP and haemoglobin levels improved in frail 12-month survivors from 13.9 to 8.3 mg/dL (p = .019) and 9.9 to 11.1 g/dL (p 
  • Postoperative delirium after hip surgery is a potential risk factor for
           incident dementia: a systematic review and meta-analysis of prospective
    • Abstract: Publication date: Available online 11 November 2019Source: Archives of Gerontology and GeriatricsAuthor(s): Soong Joon Lee, Se Hee Jung, Shi-Uk Lee, Jae-Young Lim, Kang-Sup Yoon, Sang Yoon LeeAbstractBackgroundAlthough a few trials have explored the relationship between postoperative delirium (POD) and incident dementia in patients with hip surgery, the numbers of participants in each study are relatively small. Thus, we performed a meta-analysis to examine whether POD after hip surgery is a risk factor for incident dementia.MethodsSix prospective cohort studies investigating the development of incident dementia in patients with POD after hip surgery were retrieved from PubMed, Embase, and the Cochrane Library. We performed a pairwise meta-analysis using fixed- and random- effect models.ResultsPOD significantly increased the risk of incident dementia and cognitive decline (overall odds ratio [ORs] = 8.957; 95% confidence interval [CI], 5.444–14.737; P 
  • Association between simple evaluation of eating and swallowing function
           and mortality among patients with advanced dementia in nursing homes:
           1-year prospective cohort study
    • Abstract: Publication date: Available online 9 November 2019Source: Archives of Gerontology and GeriatricsAuthor(s): Daichi Hoshino, Yutaka Watanabe, Ayako Edahiro, Yoshihiro Kugimiya, Kentaro Igarashi, Keiko Motokawa, Yuki Ohara, Hirohiko Hirano, Mie Myers, Shouji Hironaka, Yasubumi MaruokaAbstractBackgroundA simple and predictable method of evaluating eating and swallowing has not been yet established; thus, it is difficult to implement advance care planning according to deterioration in this function. This study aimed to clarify the association between a simple evaluation of eating and swallowing function and 1-year mortality in advanced dementia patients in nursing homes in Japan.MethodsThe study included 325 residents with advanced dementia. In a baseline survey, we examined medical history, physical function, and eating and swallowing function. We recorded mortality for 1 year from baseline. Kaplan-Meier survival analysis and Cox proportional regression were performed to investigate the association between the simple evaluation of eating and swallowing function and mortality.ResultsStatistical analysis included data from 312 of the 325 residents who had completed the baseline survey (7 individuals with non-oral ingestion and 6 who were alive but did not reside in the nursing home 1 year later were excluded). The participants’ mean age was 84.6 years, and 85.6% of participants were female. At the 1-year follow-up, 70 patients had died. According to Cox proportional regression analysis, age, male gender, history of cerebrovascular disorder, poor results of palpation of masseter muscle tension, and modified water swallowing test were significantly associated with 1-year mortality.ConclusionThe results of palpation of masseter muscle tension and modified water swallowing test were associated with 1-year mortality. These routine observations can predict mortality, and may thus provide evidence of the opportunity to implement advance care planning.
  • Estimating quality of life with biomarkers among older Korean adults: A
           machine-learning approach
    • Abstract: Publication date: Available online 9 November 2019Source: Archives of Gerontology and GeriatricsAuthor(s): Sung-Ha Lee, Incheol Choi, Woo-Young Ahn, Enyoung Shin, Sung-Il Cho, Sunyoung Kim, Bumjo OhAbstractBackgroundWhile health-related quality of life (HRQoL) has clinical value, its determinants, particularly objective health-related measurements, have not been fully explored. This study seeks to identify the biological indicators that relate to HRQoL among a group of older Korean adults using a machine-learning approach.MethodsWe used physical and mental scores from the 36-item Short Form Health Survey (SF-36) to measure HRQoL among older Korean adults who participated in the Korean Longitudinal Study of Aging (KLoSA) biomarker pilot study (N = 385). The variables for the multivariate penalized regression analysis included demographic factors, medical measurements, physical performance, and health-related behaviors.ResultsThe multivariate profiles identified several significant biomarkers that relate to quality of life. Among the 20 variables, handgrip strength was the most powerful indicator in both men and women for the SF-36 physical scores, followed by walking speed. Age and total sleep duration exclusively were significantly associated with the SF-36 physical scores only in women, whereas body mass index, blood pressure, and sit-to-stand times were unique elements in men.ConclusionsThe present study suggests significant physical indicators that explain quality of life in elderly populations, using a data-driven approach. Based on these findings, maintaining a good level of physical performance is considered a key element of successful aging.
  • Agreement and Predictive Power of Six Fall Risk Assessment Methods in
           Community-Dwelling Older Adults
    • Abstract: Publication date: Available online 9 November 2019Source: Archives of Gerontology and GeriatricsAuthor(s): Michele Menezes, Ney Armando de Mello Meziat-Filho, Camila Santos Araújo, Thiago Lemos, Arthur Sá FerreiraAbstractA large number of fall risk assessment methods are available with a variety of performances for screening the risk of falling in older adults, but their agreement for assessing the risk of falling remains unknown. This observational prospective cohort study describes the agreement and predictive power of methods to classify the risk of falling in older adults using prospective data and published cut-off values. Fifty-two participants aged 74 years (interquartile range 69–80) were assessed using the Berg Balance Scale, polypharmacy, Falls Risk Assessment Score, Fall Risk Assessment Tool, Fall Efficiency Scale, and Posturography. Nine participants (17%) reported at least one fall after six months. Cochran’s test showed different proportions of participants classified as at high risk of falling among all methods (Q = 69.560, p < 0.001). A slightly better-then-chance agreement was estimated between all FRA methods (Light’s κ = 0.074, 95%CI [0.021; 0.142]). We found both global and pairwise agreement levels that question the agreement among fall risk assessment methods for screening community-dwelling older adults.
  • The Impact of Age, Surface Characteristics, and Dual-tasking on Postural
    • Abstract: Publication date: Available online 9 November 2019Source: Archives of Gerontology and GeriatricsAuthor(s): Diana Hsiao, Pooja Belur, Peter S. Myers, Gammon M. Earhart, Kerri S. RawsonAbstractPostural control integrates somatosensory, vestibular, and visual input to maintain balance. Age, dual-tasking (DT), and varying surfaces may impact postural control and lead to falls. Research suggests smartphone use is a growing safety hazard, as it reduces situational awareness while increasing dual-task costs (DTCs). Therefore, we examined postural control using a modern, motor-cognitive, dual-task paradigm and examined DTCs associated with age, surface characteristic, and type of DT. Younger (n=24) and older (n=26) participants completed three 30- second trials of six different task conditions. Participants either stood quietly (single-task) or performed a secondary, word generation task (dual-task) that included verbally listing words (verbal) or typing words (texting) on a smartphone within a given category (e.g., vegetables) while on a firm, stable surface (level floor) or compliant, unstable surface (foam pad). Repeated-measures MANOVAs tested differences in postural sway (measured by sway angle, velocity, and acceleration) between age groups and task conditions. Results indicated poorer performance on the verbal DT than texting DT while standing on the level floor; performance was similar between the two DTs when standing on the foam pad. We also found poorer performance on the foam pad compared to level floor while texting; performance was similar between surfaces for the verbal DT. Younger adults generally had better performance than older adults within each task, particularly for texting on the level floor. In summary, older age, verbal tasks, and compliant, unstable surfaces have greater impact on postural control parameters compared to younger age, texting, and firm, stable surfaces.
  • Sex-differences in relation to the association between patterns of
           physical activity and sedentary behavior with frailty
    • Abstract: Publication date: Available online 7 November 2019Source: Archives of Gerontology and GeriatricsAuthor(s): D. Scott Kehler, Ian Clara, Brett Hiebert, Andrew N. Stammers, Jacqueline L. Hay, Annette Schultz, Rakesh C. Arora, Navdeep Tangri, Todd A. DuhamelAbstractObjectiveTo investigate the sex-difference in relation to the association between moderate-vigorous physical activity (MVPA) and sedentary time (ST) patterns with frailty.MethodAccelerometry from ≥50 year olds from the National Health and Nutrition Examination Survey (2003-04/2005-06 cycles) were included. Bouted and sporadic MVPA were defined as MVPA in ≥10 minute or
  • Sleep quality among Chinese elderly people: a population-based study
    • Abstract: Publication date: Available online 24 October 2019Source: Archives of Gerontology and GeriatricsAuthor(s): Ning Li, Guangming Xu, Gong Chen, Xiaoying ZhengAbstractLittle was known about sleep quality among Chinese population. Using data from a population-based survey, we aimed to describe the prevalence of poor sleep quality among Chinese elderly people, to analyze factors associated with poor sleep quality, and to explore the relation between sleep quality and life quality as well as the risk for mental disorders. Data was derived from the Tianjin Mental Health Survey. The 19-item Pittsburg Sleep Quality Index was used to assess sleep quality. Life quality was evaluated using a Chinese version of Quality of Life Scale. To investigate the risk for mental disorders, the Chinese version of General Health Questionnaire was administered. Female gender, older age, low educational attainment, poor subject family economic status, and not having health insurance were significantly associated with elevated risk of poor sleep quality. Poor sleep quality was associated with poor life quality and increased odds of mental disorders. Further studies are warranted for the evaluation of effectiveness of screening tools for sleep problems and the generalization of early screening and diagnosing programs in the nation. Early screening is necessary and appropriate intervention programs should be conducted in the population with high risk.
  • Limitations of SARC-F in the diagnosis of sarcopenia in community-dwelling
           older adults
    • Abstract: Publication date: Available online 24 September 2019Source: Archives of Gerontology and GeriatricsAuthor(s): Takeshi Kera, Hisashi Kawai, Hirohiko Hirano, Motonaga Kojima, Yutaka Watanabe, Keiko Motokawa, Yoshinori Fujiwara, Yosuke Osuka, Narumi Kojima, Hunkyung Kim, Kazushige Ihara, Shuichi ObuchiAbstractPurposeThe SARC-F is a recommended screening tool for sarcopenia; however, its sensitivity is reported to be very low. This study aimed to confirm the diagnostic efficacy of the SARC-F and whether it is affected by population characteristics.MethodsIn this study, 2 cohorts of 1,060 community-dwelling older adults, who were monitored by the Tokyo Metropolitan Institute of Gerontology, were included. In addition to the overall dataset, receiver operating characteristic curve analysis was performed to obtain the SARC-F results for sarcopenia among the datasets for only older age (over 75 years), higher frailty points (above the median of the Kihon Checklist points), lower grip strength (below the median), lower gait speed (below the median), and comorbidities (hypertension, cerebral vascular disease, heart disease, and diabetes mellitus).ResultsIn the overall dataset, sensitivity and specificity were 3.9% and 97.3%, respectively. In analyzing the area under the curve, sensitivity and specificity for older age and low physical function datasets were significant, but had low values. The diabetes dataset had higher values but did not effectively diagnose sarcopenia at a cutoff value of 4.ConclusionThe SARC-F had high specificity for the diagnosis of sarcopenia in community-dwelling older adults with low physical function. However, its sensitivity was low. Despite these limitations, it may be used as a screening tool for sarcopenia in selected populations, such as adults in hospitals or nursing homes.
  • Corrigendum to “Psychometric evaluation of the patient perspective on
           care and rehabilitation scale in geriatric patients” [Arch. Gerontol.
           Geriatr. 81 (March–April) (2019) 84–90]
    • Abstract: Publication date: Available online 12 July 2019Source: Archives of Gerontology and GeriatricsAuthor(s): Behice Erci, Hilal Yildirim, Kevser Isik
  • Correlation between Potentially Inappropriate Medication and Alzheimer’s
           Disease among the Elderly
    • Abstract: Publication date: Available online 13 March 2019Source: Archives of Gerontology and GeriatricsAuthor(s): Ping Tao, Pei-En Chen, Jung Tao, Sheau-Ning Yang, Tao-Hsin Tung, Ching-Wen ChienAbstractPurposeThis study is conducted to explore the association between potentially inappropriate medication (PIM) and Alzheimer’s disease (AD) among the elderly.MethodsWe used Taiwan’s National Health Insurance Research Database (NHIRD) to conduct a nationwide case-control study. Elderly individuals (over 65 years of age) who had been diagnosed with AD (ICD-9-CM: 331.0) for the first time in 2011 were selected as subjects for the case group. A control group was formed by selecting elderly patients without AD using 1:1 propensity score matching. Control variables included sex, age, health status, and 31 Elixhauser comorbidities. All analyses were performed using the Resource Utilization Band (Adjusted Clinical Groups software). All health utilization data associated with PIM were traced back for a period of 5 years. We examined the odds ratio (OR) and 95% confidence interval (CI) for PIM in relation to AD.ResultsWe identified 5,264 patients with AD (case group) and 5,264 non-AD controls. After adjustment for confounding factors, proportion of all PIM (adjusted OR: 1.006, 95%CI: 1.002-1.010, p-value = 0.009) was significantly associated with AD.ConclusionIn conclusion, we observed a significant positive correlation between PIM and AD among elderly population.
  • Childhood socioeconomic disadvantage as a determinant of late-life
           physical function in older Japanese people
    • Abstract: Publication date: Available online 29 May 2019Source: Archives of Gerontology and GeriatricsAuthor(s): Hiroshi Murayama, Mika Sugiyama, Hiroki Inagaki, Ayako Edahiro, Tsuyoshi Okamura, Chiaki Ura, Fumiko Miyamae, Keiko Motokawa, Shuichi AwataABSTRACTBackgroundIn this study, we examined the relationship between childhood socioeconomic status and physical function among older Japanese people, and investigated whether there is a sex variation in this association.MethodsWe administered a cross-sectional questionnaire survey to all independent community-dwelling individuals ≥65 years old, living in Adachi Ward, Tokyo (N = 132,005). Participants self-reported their physical function using the Motor Fitness Scale, and we divided the scores into quartiles for analysis. Childhood socioeconomic status was retrospectively assessed according to a single item.ResultsWe analyzed 75,358 questionnaires. The average age of participants was 73.8 ± 6.0 years, and 55.0% were women. An ordered logistic regression analysis showed that lower childhood socioeconomic status was associated with lower physical function, independent of adult sociodemographic factors, health behaviors, and health conditions. This association was stronger in women than in men.ConclusionsOur findings indicate that low childhood socioeconomic status might have a long-term influence on physical function in late life and that this influence varies by sex. Assessment of socioeconomic disadvantage in childhood is important for developing strategies to help older people maintain their physical function longer.
  • A review of published anticholinergic scales and measures and their
           applicability in database analyses
    • Abstract: Publication date: Available online 13 May 2019Source: Archives of Gerontology and GeriatricsAuthor(s): Greta Lozano-Ortega, Karissa M. Johnston, Antoinette Cheung, Adrian Wagg, Noll L. Campbell, Roger R. Dmochowski, Daniel B. NgAbstractBackground/ObjectivesAvailable metrics for characterizing cumulative anticholinergic exposure over time may not be well suited for use across all US data sources. In this review, the properties of existing anticholinergic scales and measures were evaluated to determine their suitability for implementation in observational studies relying on administrative data.MethodsA targeted literature review was conducted to identify available anticholinergic scales and measures. Suitability of the identified scales and measures for quantification of anticholinergic exposure was evaluated based on pre-defined criteria. Agreement between selected scales was characterized by the percentage overlap of included drugs and inter-scale Spearman’s correlation of scores.ResultsSixteen scales were identified; six were relevant and suitable for the quantification of anticholinergic exposure. When implemented on administrative data the Anticholinergic Drug Scale and Anticholinergic Cognitive Burden scale demonstrated the most agreement, with an inter-scale correlation coefficient of 0.82. Scale performance varied by outcome of interest, and underlying disease profile of the population of interest. Variability across the two measures (“average daily dose” and “cumulative dose”) was observed, with neither considering both dose and anticholinergic potency in score calculations.ConclusionsAccurate quantification of anticholinergic burden is important in assessing relative risks versus benefits of prescribing anticholinergic medications. In this review, the Anticholinergic Drug Scale and the Anticholinergic Cognitive Burden scale and the average daily dose and cumulative dose measures, were determined to be well suited for the quantification of anticholinergic exposure, particularly in the context of administrative data analyses; however, methods to characterize anticholinergic burden through consideration of both anticholinergic dose and potency are needed.
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Heriot-Watt University
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